TY  - JOUR
AU  - Matić, Ivana Z.
AU  - Aljančić, Ivana
AU  - Žižak, Željko S.
AU  - Vajs, Vlatka
AU  - Jadranin, Milka
AU  - Milosavljević, Slobodan M.
AU  - Juranić, Zorica D.
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1608
AB  - Background: The aim of this research was to determine the intensity and mechanisms of the cytotoxic actions of five extracts isolated from the endemic plant species Helichrysum zivojinii Cernjavski & Soska (family Asteraceae) against specific cancer cell lines. In order to evaluate the sensitivity of normal immunocompetent cells implicated in the antitumor immune response, the cytotoxicity of extracts was also tested against healthy peripheral blood mononuclear cells (PBMC). Methods: The aerial parts of the plants were air-dried, powdered, and successively extracted with solvents of increasing polarity to obtain hexane, dichloromethane, ethyl-acetate, n-butanol and methanol extracts. The cytotoxic activities of the extracts against human cervix adenocarcinoma HeLa, human melanoma Fem-x, human myelogenous leukemia K562, human breast adenocarcinoma MDA-MB-361 cells and PBMC were evaluated by the MTT test. The mode of HeLa cell death was investigated by morphological analysis. Changes in the cell cycle of HeLa cells treated with the extracts were analyzed by flow cytometry. The apoptotic mechanisms induced by the tested extracts were determined using specific caspase inhibitors. Results: The investigated Helichrysum zivojinii extracts exerted selective dose-dependent cytotoxic actions against selected cancer cell lines and healthy immunocompetent PBMC stimulated to proliferate, while the cytotoxic actions exerted on unstimulated PBMC were less pronounced. The tested extracts exhibited considerably stronger cytotoxic activities towards HeLa, Fem-x and K562 cells in comparison to resting and stimulated PBMC. It is worth noting that the cytotoxicity of the extracts was weaker against unstimulated PBMC in comparison to stimulated PBMC. Furthermore, each of the five extracts induced apoptosis in HeLa cells, through the activation of both intrinsic and extrinsic signaling pathways. Conclusion: Extracts obtained from the endemic plant Helichrysum zivojinii may represent an important source of novel potential antitumor agents due to their pronounced and selective cytotoxic actions towards malignant cells.
PB  - Biomed Central Ltd, London
T2  - BMC Complementary and Alternative Medicine
T1  - In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii
VL  - 13
DO  - 10.1186/1472-6882-13-36
ER  - 

@article{
author = "Matić, Ivana Z. and Aljančić, Ivana and Žižak, Željko S. and Vajs, Vlatka and Jadranin, Milka and Milosavljević, Slobodan M. and Juranić, Zorica D.",
year = "2013",
abstract = "Background: The aim of this research was to determine the intensity and mechanisms of the cytotoxic actions of five extracts isolated from the endemic plant species Helichrysum zivojinii Cernjavski & Soska (family Asteraceae) against specific cancer cell lines. In order to evaluate the sensitivity of normal immunocompetent cells implicated in the antitumor immune response, the cytotoxicity of extracts was also tested against healthy peripheral blood mononuclear cells (PBMC). Methods: The aerial parts of the plants were air-dried, powdered, and successively extracted with solvents of increasing polarity to obtain hexane, dichloromethane, ethyl-acetate, n-butanol and methanol extracts. The cytotoxic activities of the extracts against human cervix adenocarcinoma HeLa, human melanoma Fem-x, human myelogenous leukemia K562, human breast adenocarcinoma MDA-MB-361 cells and PBMC were evaluated by the MTT test. The mode of HeLa cell death was investigated by morphological analysis. Changes in the cell cycle of HeLa cells treated with the extracts were analyzed by flow cytometry. The apoptotic mechanisms induced by the tested extracts were determined using specific caspase inhibitors. Results: The investigated Helichrysum zivojinii extracts exerted selective dose-dependent cytotoxic actions against selected cancer cell lines and healthy immunocompetent PBMC stimulated to proliferate, while the cytotoxic actions exerted on unstimulated PBMC were less pronounced. The tested extracts exhibited considerably stronger cytotoxic activities towards HeLa, Fem-x and K562 cells in comparison to resting and stimulated PBMC. It is worth noting that the cytotoxicity of the extracts was weaker against unstimulated PBMC in comparison to stimulated PBMC. Furthermore, each of the five extracts induced apoptosis in HeLa cells, through the activation of both intrinsic and extrinsic signaling pathways. Conclusion: Extracts obtained from the endemic plant Helichrysum zivojinii may represent an important source of novel potential antitumor agents due to their pronounced and selective cytotoxic actions towards malignant cells.",
publisher = "Biomed Central Ltd, London",
journal = "BMC Complementary and Alternative Medicine",
title = "In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii",
volume = "13",
doi = "10.1186/1472-6882-13-36"
}

Matić, I. Z., Aljančić, I., Žižak, Ž. S., Vajs, V., Jadranin, M., Milosavljević, S. M.,& Juranić, Z. D.. (2013). In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii. in BMC Complementary and Alternative Medicine
Biomed Central Ltd, London., 13.
https://doi.org/10.1186/1472-6882-13-36

Matić IZ, Aljančić I, Žižak ŽS, Vajs V, Jadranin M, Milosavljević SM, Juranić ZD. In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii. in BMC Complementary and Alternative Medicine. 2013;13.
doi:10.1186/1472-6882-13-36 .

Matić, Ivana Z., Aljančić, Ivana, Žižak, Željko S., Vajs, Vlatka, Jadranin, Milka, Milosavljević, Slobodan M., Juranić, Zorica D., "In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii" in BMC Complementary and Alternative Medicine, 13 (2013),
https://doi.org/10.1186/1472-6882-13-36 . .

TY  - CONF
AU  - Žižak, Željko S.
AU  - Opsenica, Dejan M.
AU  - Šolaja, Bogdan A.
AU  - Juranić, Z.
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1572
PB  - Elsevier Sci Ltd, Oxford
C3  - European Journal of Cancer / EJC
T1  - Investigation of Some Small Heterocyclic Compounds as Potential Antitumor Agents
VL  - 48
DO  - 10.1016/S0959-8049(12)71674-X
ER  - 

@conference{
author = "Žižak, Željko S. and Opsenica, Dejan M. and Šolaja, Bogdan A. and Juranić, Z.",
year = "2012",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "European Journal of Cancer / EJC",
title = "Investigation of Some Small Heterocyclic Compounds as Potential Antitumor Agents",
volume = "48",
doi = "10.1016/S0959-8049(12)71674-X"
}

Žižak, Ž. S., Opsenica, D. M., Šolaja, B. A.,& Juranić, Z.. (2012). Investigation of Some Small Heterocyclic Compounds as Potential Antitumor Agents. in European Journal of Cancer / EJC
Elsevier Sci Ltd, Oxford., 48.
https://doi.org/10.1016/S0959-8049(12)71674-X

Žižak ŽS, Opsenica DM, Šolaja BA, Juranić Z. Investigation of Some Small Heterocyclic Compounds as Potential Antitumor Agents. in European Journal of Cancer / EJC. 2012;48.
doi:10.1016/S0959-8049(12)71674-X .

Žižak, Željko S., Opsenica, Dejan M., Šolaja, Bogdan A., Juranić, Z., "Investigation of Some Small Heterocyclic Compounds as Potential Antitumor Agents" in European Journal of Cancer / EJC, 48 (2012),
https://doi.org/10.1016/S0959-8049(12)71674-X . .

TY  - CONF
AU  - Matic, I.
AU  - Juranić, Z.
AU  - Žižak, Željko S.
AU  - Vajs, Vlatka
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan M.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1164
PB  - Pergamon-Elsevier Science Ltd, Oxford
C3  - European Journal of Cancer Supplements / EJC Supplements
T1  - Extracts from endemic plant Helichrysum zivojini suppress survival of malignant cells
VL  - 8
IS  - 5
SP  - 150
EP  - 150
DO  - 10.1016/S1359-6349(10)71390-2
ER  - 

@conference{
author = "Matic, I. and Juranić, Z. and Žižak, Željko S. and Vajs, Vlatka and Aljančić, Ivana and Milosavljević, Slobodan M.",
year = "2010",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "European Journal of Cancer Supplements / EJC Supplements",
title = "Extracts from endemic plant Helichrysum zivojini suppress survival of malignant cells",
volume = "8",
number = "5",
pages = "150-150",
doi = "10.1016/S1359-6349(10)71390-2"
}

Matic, I., Juranić, Z., Žižak, Ž. S., Vajs, V., Aljančić, I.,& Milosavljević, S. M.. (2010). Extracts from endemic plant Helichrysum zivojini suppress survival of malignant cells. in European Journal of Cancer Supplements / EJC Supplements
Pergamon-Elsevier Science Ltd, Oxford., 8(5), 150-150.
https://doi.org/10.1016/S1359-6349(10)71390-2

Matic I, Juranić Z, Žižak ŽS, Vajs V, Aljančić I, Milosavljević SM. Extracts from endemic plant Helichrysum zivojini suppress survival of malignant cells. in European Journal of Cancer Supplements / EJC Supplements. 2010;8(5):150-150.
doi:10.1016/S1359-6349(10)71390-2 .

Matic, I., Juranić, Z., Žižak, Željko S., Vajs, Vlatka, Aljančić, Ivana, Milosavljević, Slobodan M., "Extracts from endemic plant Helichrysum zivojini suppress survival of malignant cells" in European Journal of Cancer Supplements / EJC Supplements, 8, no. 5 (2010):150-150,
https://doi.org/10.1016/S1359-6349(10)71390-2 . .

TY  - JOUR
AU  - Cvijetić, Ilija
AU  - Žižak, Željko S.
AU  - Stanojković, Tatjana
AU  - Juranić, Zorica D.
AU  - Terzić-Jovanović, Nataša
AU  - Opsenica, Igor
AU  - Opsenica, Dejan M.
AU  - Juranić, Ivan O.
AU  - Drakulić, Branko J.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1120
AB  - An alignment-free 3D QSAR study on antiproliferative activity of the thirty-three 1,2,4,5-tetraoxane derivatives toward two human dedifferentiated cell lines was reported. GRIND methodology, where descriptors are derived from GRID molecular interaction fields (MIF), were used It was found that pharmacophoric pattern attributed to the most potent derivatives Include amido NH of the primary or secondary amide, and the acetoxy fragments at positions 7 and 12 of steroid core which are, along with the tetraoxane ring, common for all studied compounds. Independently, simple multiple regression model obtained by using the whole-molecular properties, confirmed that the hydrophobicity and the H-bond donor properties are the main parameters influencing potency of compounds toward human cervix carcinoma (HeLa) and human malignant melanoma (FemX) cell lines Corollary, similar structural motifs are found to be Important for the potency toward both examined cell lines. (C) 2010 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2  - European Journal of Medicinal Chemistry
T1  - An alignment independent 3D QSAR study of the antiproliferative activity of 1,2,4,5-tetraoxanes
VL  - 45
IS  - 10
SP  - 4570
EP  - 4577
DO  - 10.1016/j.ejmech.2010.07.019
ER  - 

@article{
author = "Cvijetić, Ilija and Žižak, Željko S. and Stanojković, Tatjana and Juranić, Zorica D. and Terzić-Jovanović, Nataša and Opsenica, Igor and Opsenica, Dejan M. and Juranić, Ivan O. and Drakulić, Branko J.",
year = "2010",
abstract = "An alignment-free 3D QSAR study on antiproliferative activity of the thirty-three 1,2,4,5-tetraoxane derivatives toward two human dedifferentiated cell lines was reported. GRIND methodology, where descriptors are derived from GRID molecular interaction fields (MIF), were used It was found that pharmacophoric pattern attributed to the most potent derivatives Include amido NH of the primary or secondary amide, and the acetoxy fragments at positions 7 and 12 of steroid core which are, along with the tetraoxane ring, common for all studied compounds. Independently, simple multiple regression model obtained by using the whole-molecular properties, confirmed that the hydrophobicity and the H-bond donor properties are the main parameters influencing potency of compounds toward human cervix carcinoma (HeLa) and human malignant melanoma (FemX) cell lines Corollary, similar structural motifs are found to be Important for the potency toward both examined cell lines. (C) 2010 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "European Journal of Medicinal Chemistry",
title = "An alignment independent 3D QSAR study of the antiproliferative activity of 1,2,4,5-tetraoxanes",
volume = "45",
number = "10",
pages = "4570-4577",
doi = "10.1016/j.ejmech.2010.07.019"
}

Cvijetić, I., Žižak, Ž. S., Stanojković, T., Juranić, Z. D., Terzić-Jovanović, N., Opsenica, I., Opsenica, D. M., Juranić, I. O.,& Drakulić, B. J.. (2010). An alignment independent 3D QSAR study of the antiproliferative activity of 1,2,4,5-tetraoxanes. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 45(10), 4570-4577.
https://doi.org/10.1016/j.ejmech.2010.07.019

Cvijetić I, Žižak ŽS, Stanojković T, Juranić ZD, Terzić-Jovanović N, Opsenica I, Opsenica DM, Juranić IO, Drakulić BJ. An alignment independent 3D QSAR study of the antiproliferative activity of 1,2,4,5-tetraoxanes. in European Journal of Medicinal Chemistry. 2010;45(10):4570-4577.
doi:10.1016/j.ejmech.2010.07.019 .

Cvijetić, Ilija, Žižak, Željko S., Stanojković, Tatjana, Juranić, Zorica D., Terzić-Jovanović, Nataša, Opsenica, Igor, Opsenica, Dejan M., Juranić, Ivan O., Drakulić, Branko J., "An alignment independent 3D QSAR study of the antiproliferative activity of 1,2,4,5-tetraoxanes" in European Journal of Medicinal Chemistry, 45, no. 10 (2010):4570-4577,
https://doi.org/10.1016/j.ejmech.2010.07.019 . .

TY  - CONF
AU  - Žižak, Željko S.
AU  - Juranić, Z.
AU  - Opsenica, Dejan M.
AU  - Šolaja, Bogdan A.
AU  - Besu, I.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1163
PB  - Pergamon-Elsevier Science Ltd, Oxford
C3  - European Journal of Cancer Supplements / EJC Supplements
T1  - Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells
VL  - 8
IS  - 5
SP  - 131
EP  - 131
DO  - 10.1016/S1359-6349(10)71313-6
ER  - 

@conference{
author = "Žižak, Željko S. and Juranić, Z. and Opsenica, Dejan M. and Šolaja, Bogdan A. and Besu, I.",
year = "2010",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "European Journal of Cancer Supplements / EJC Supplements",
title = "Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells",
volume = "8",
number = "5",
pages = "131-131",
doi = "10.1016/S1359-6349(10)71313-6"
}

Žižak, Ž. S., Juranić, Z., Opsenica, D. M., Šolaja, B. A.,& Besu, I.. (2010). Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells. in European Journal of Cancer Supplements / EJC Supplements
Pergamon-Elsevier Science Ltd, Oxford., 8(5), 131-131.
https://doi.org/10.1016/S1359-6349(10)71313-6

Žižak ŽS, Juranić Z, Opsenica DM, Šolaja BA, Besu I. Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells. in European Journal of Cancer Supplements / EJC Supplements. 2010;8(5):131-131.
doi:10.1016/S1359-6349(10)71313-6 .

Žižak, Željko S., Juranić, Z., Opsenica, Dejan M., Šolaja, Bogdan A., Besu, I., "Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells" in European Journal of Cancer Supplements / EJC Supplements, 8, no. 5 (2010):131-131,
https://doi.org/10.1016/S1359-6349(10)71313-6 . .

TY  - JOUR
AU  - Žižak, Željko S.
AU  - Juranić, Zorica D.
AU  - Opsenica, Dejan M.
AU  - Šolaja, Bogdan A.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1012
AB  - In this study we investigated the antiproliferative activity of six mixed steroidal tetraoxanes against various tumor cell lines, the toxicity against normal peripheral blood mononuclear cells (PBMC), and the mode of HeLa cell death induced by these compounds. Investigated tetraoxanes exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. Treatment of HeLa cells for 24 h with all tetraoxanes induced apoptosis, as confirmed by morphological analysis and by the appearance of a typical ladder pattern in the DNA fragmentation assay.
PB  - Springer, Dordrecht
T2  - Investigational New Drugs
T1  - Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells
VL  - 27
IS  - 5
SP  - 432
EP  - 439
DO  - 10.1007/s10637-008-9197-1
ER  - 

@article{
author = "Žižak, Željko S. and Juranić, Zorica D. and Opsenica, Dejan M. and Šolaja, Bogdan A.",
year = "2009",
abstract = "In this study we investigated the antiproliferative activity of six mixed steroidal tetraoxanes against various tumor cell lines, the toxicity against normal peripheral blood mononuclear cells (PBMC), and the mode of HeLa cell death induced by these compounds. Investigated tetraoxanes exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. Treatment of HeLa cells for 24 h with all tetraoxanes induced apoptosis, as confirmed by morphological analysis and by the appearance of a typical ladder pattern in the DNA fragmentation assay.",
publisher = "Springer, Dordrecht",
journal = "Investigational New Drugs",
title = "Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells",
volume = "27",
number = "5",
pages = "432-439",
doi = "10.1007/s10637-008-9197-1"
}

Žižak, Ž. S., Juranić, Z. D., Opsenica, D. M.,& Šolaja, B. A.. (2009). Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells. in Investigational New Drugs
Springer, Dordrecht., 27(5), 432-439.
https://doi.org/10.1007/s10637-008-9197-1

Žižak ŽS, Juranić ZD, Opsenica DM, Šolaja BA. Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells. in Investigational New Drugs. 2009;27(5):432-439.
doi:10.1007/s10637-008-9197-1 .

Žižak, Željko S., Juranić, Zorica D., Opsenica, Dejan M., Šolaja, Bogdan A., "Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells" in Investigational New Drugs, 27, no. 5 (2009):432-439,
https://doi.org/10.1007/s10637-008-9197-1 . .

TY  - JOUR
AU  - Djinovic, Vesna M.
AU  - Todorović, Tamara
AU  - Žižak, Željko S.
AU  - Sabo, Tibor
AU  - Juranić, Zorica D.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/591
AB  - Ruthenium(III) complexes formulated as K2[Ru(sar)Cl4]H2O and K[Ru(dmgly)2Cl2]3H2O containing bidentate chelates N-methylglycine (sarcosine, sar) or N,N-dimethylglycine (dmgly) as well as K[Ru(pdda)Cl2]2.5H2O complex with tetradentate 1,3-propylenediamine-N,N'-diacetato were synthesized. The complexes were obtained by direct reaction of ruthenium(III) chloride with the corresponding bidentate or tetradentate ligand followed by addition of a base (KOH). These new complexes were characterized by elemental analysis, IR and electronic absorption spectroscopy. To assess selectivity in the antitumor action of these complexes, their antiproliferative activities against human adenocarcinoma HeLa cells, human myelogenous leukemia K562 cells, human breast carcinoma MDA-MB-361 and MDA-MB-453 cells and normal immunocompetent PBM cells were determined.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Coordination Chemistry
T1  - Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC
VL  - 62
IS  - 2
SP  - 328
EP  - 336
DO  - 10.1080/00958970802233128
ER  - 

@article{
author = "Djinovic, Vesna M. and Todorović, Tamara and Žižak, Željko S. and Sabo, Tibor and Juranić, Zorica D.",
year = "2009",
abstract = "Ruthenium(III) complexes formulated as K2[Ru(sar)Cl4]H2O and K[Ru(dmgly)2Cl2]3H2O containing bidentate chelates N-methylglycine (sarcosine, sar) or N,N-dimethylglycine (dmgly) as well as K[Ru(pdda)Cl2]2.5H2O complex with tetradentate 1,3-propylenediamine-N,N'-diacetato were synthesized. The complexes were obtained by direct reaction of ruthenium(III) chloride with the corresponding bidentate or tetradentate ligand followed by addition of a base (KOH). These new complexes were characterized by elemental analysis, IR and electronic absorption spectroscopy. To assess selectivity in the antitumor action of these complexes, their antiproliferative activities against human adenocarcinoma HeLa cells, human myelogenous leukemia K562 cells, human breast carcinoma MDA-MB-361 and MDA-MB-453 cells and normal immunocompetent PBM cells were determined.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Coordination Chemistry",
title = "Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC",
volume = "62",
number = "2",
pages = "328-336",
doi = "10.1080/00958970802233128"
}

Djinovic, V. M., Todorović, T., Žižak, Ž. S., Sabo, T.,& Juranić, Z. D.. (2009). Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC. in Journal of Coordination Chemistry
Taylor & Francis Ltd, Abingdon., 62(2), 328-336.
https://doi.org/10.1080/00958970802233128

Djinovic VM, Todorović T, Žižak ŽS, Sabo T, Juranić ZD. Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC. in Journal of Coordination Chemistry. 2009;62(2):328-336.
doi:10.1080/00958970802233128 .

Djinovic, Vesna M., Todorović, Tamara, Žižak, Željko S., Sabo, Tibor, Juranić, Zorica D., "Ru(III) complexes derived from N-methyl derivatives of glycine and 1,3-propylenediamine-N,N'-diacetato ligands and their activities against HeLa, K562 cell lines and human PBMC" in Journal of Coordination Chemistry, 62, no. 2 (2009):328-336,
https://doi.org/10.1080/00958970802233128 . .

TY  - JOUR
AU  - Vitnik, V. D.
AU  - Ivanović, Milovan
AU  - Vitnik, Z. J.
AU  - Dordevic, J. B.
AU  - Žižak, Željko S.
AU  - Juranic, Z. D.
AU  - Juranić, Ivan O.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/616
AB  - Phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent result in the formation of alpha,beta-unsaturated carboxylic acids. The reaction was performed at room temperature for 24h. The corresponding conjugated acids were obtained from cyclic or aromatic ketones, whereas bromo acids were obtained from 4-oxo-piperidine-1-carboxylic acid ethyl ester (13) and 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (14).
PB  - Taylor & Francis Inc, Philadelphia
T2  - Synthetic Communications
T1  - One-Step Conversion of Ketones to Conjugated Acids Using Bromoform
VL  - 39
IS  - 8
SP  - 1457
EP  - 1471
DO  - 10.1080/00397910802531955
ER  - 

@article{
author = "Vitnik, V. D. and Ivanović, Milovan and Vitnik, Z. J. and Dordevic, J. B. and Žižak, Željko S. and Juranic, Z. D. and Juranić, Ivan O.",
year = "2009",
abstract = "Phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent result in the formation of alpha,beta-unsaturated carboxylic acids. The reaction was performed at room temperature for 24h. The corresponding conjugated acids were obtained from cyclic or aromatic ketones, whereas bromo acids were obtained from 4-oxo-piperidine-1-carboxylic acid ethyl ester (13) and 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (14).",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Synthetic Communications",
title = "One-Step Conversion of Ketones to Conjugated Acids Using Bromoform",
volume = "39",
number = "8",
pages = "1457-1471",
doi = "10.1080/00397910802531955"
}

Vitnik, V. D., Ivanović, M., Vitnik, Z. J., Dordevic, J. B., Žižak, Ž. S., Juranic, Z. D.,& Juranić, I. O.. (2009). One-Step Conversion of Ketones to Conjugated Acids Using Bromoform. in Synthetic Communications
Taylor & Francis Inc, Philadelphia., 39(8), 1457-1471.
https://doi.org/10.1080/00397910802531955

Vitnik VD, Ivanović M, Vitnik ZJ, Dordevic JB, Žižak ŽS, Juranic ZD, Juranić IO. One-Step Conversion of Ketones to Conjugated Acids Using Bromoform. in Synthetic Communications. 2009;39(8):1457-1471.
doi:10.1080/00397910802531955 .

Vitnik, V. D., Ivanović, Milovan, Vitnik, Z. J., Dordevic, J. B., Žižak, Željko S., Juranic, Z. D., Juranić, Ivan O., "One-Step Conversion of Ketones to Conjugated Acids Using Bromoform" in Synthetic Communications, 39, no. 8 (2009):1457-1471,
https://doi.org/10.1080/00397910802531955 . .

TY  - JOUR
AU  - Zmejkovski, Bojana B.
AU  - Kaluđerović, Goran N.
AU  - Gomez-Ruiz, Santiago
AU  - Žižak, Željko S.
AU  - Steinborn, Dirk
AU  - Schmidt, Harry
AU  - Paschke, Reinhard
AU  - Juranić, Zorica D.
AU  - Sabo, Tibor
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1005
AB  - New R(2)eddip-type esters (R = cyclopentyl, L3 center dot 2HCl 1.5H(2)O; cyclohexyl, L4 center dot 2HCl center dot H2O) and corresponding palladium(II) complexes, [PdCl(2)L3] (3) and [PdCl2L4]center dot H2O (4), as well as [PdCl2L2] (2: L2 diisobutyl ester of eddip) were synthesized and characterized by IR, H-1 and C-13 NMR spectroscopies and elemental analysis. The crystal structure of L3 center dot 2HCl center dot 2CHCl(3) was resolved and is given herein. The NMR spectroscopy confirmed the presence of two isomers (from three possible) for each palladium(II) complex. DFT calculations support the formation of two diastereoisomers. In addition, antitumoral investigations were performed and these investigations also included the diisopropyl ester of eddip (L1) and corresponding palladium(II) complex, [PdCl(2)L1] (1). In vitro anti proliferative activity was determined against several tumor cell lines HeLa, Fem-x, K562 and rested and stimulated normal immunocompetent cells (human peripheral blood mononuclear cells -PBMCs) using MTT test. (C) 2009 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2  - European Journal of Medicinal Chemistry
T1  - Palladium(II) complexes with R(2)edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R(2)eddip esters and palladium(II) complexes
VL  - 44
IS  - 9
SP  - 3452
EP  - 3458
DO  - 10.1016/j.ejmech.2009.02.002
ER  - 

@article{
author = "Zmejkovski, Bojana B. and Kaluđerović, Goran N. and Gomez-Ruiz, Santiago and Žižak, Željko S. and Steinborn, Dirk and Schmidt, Harry and Paschke, Reinhard and Juranić, Zorica D. and Sabo, Tibor",
year = "2009",
abstract = "New R(2)eddip-type esters (R = cyclopentyl, L3 center dot 2HCl 1.5H(2)O; cyclohexyl, L4 center dot 2HCl center dot H2O) and corresponding palladium(II) complexes, [PdCl(2)L3] (3) and [PdCl2L4]center dot H2O (4), as well as [PdCl2L2] (2: L2 diisobutyl ester of eddip) were synthesized and characterized by IR, H-1 and C-13 NMR spectroscopies and elemental analysis. The crystal structure of L3 center dot 2HCl center dot 2CHCl(3) was resolved and is given herein. The NMR spectroscopy confirmed the presence of two isomers (from three possible) for each palladium(II) complex. DFT calculations support the formation of two diastereoisomers. In addition, antitumoral investigations were performed and these investigations also included the diisopropyl ester of eddip (L1) and corresponding palladium(II) complex, [PdCl(2)L1] (1). In vitro anti proliferative activity was determined against several tumor cell lines HeLa, Fem-x, K562 and rested and stimulated normal immunocompetent cells (human peripheral blood mononuclear cells -PBMCs) using MTT test. (C) 2009 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "European Journal of Medicinal Chemistry",
title = "Palladium(II) complexes with R(2)edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R(2)eddip esters and palladium(II) complexes",
volume = "44",
number = "9",
pages = "3452-3458",
doi = "10.1016/j.ejmech.2009.02.002"
}

Zmejkovski, B. B., Kaluđerović, G. N., Gomez-Ruiz, S., Žižak, Ž. S., Steinborn, D., Schmidt, H., Paschke, R., Juranić, Z. D.,& Sabo, T.. (2009). Palladium(II) complexes with R(2)edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R(2)eddip esters and palladium(II) complexes. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 44(9), 3452-3458.
https://doi.org/10.1016/j.ejmech.2009.02.002

Zmejkovski BB, Kaluđerović GN, Gomez-Ruiz S, Žižak ŽS, Steinborn D, Schmidt H, Paschke R, Juranić ZD, Sabo T. Palladium(II) complexes with R(2)edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R(2)eddip esters and palladium(II) complexes. in European Journal of Medicinal Chemistry. 2009;44(9):3452-3458.
doi:10.1016/j.ejmech.2009.02.002 .

Zmejkovski, Bojana B., Kaluđerović, Goran N., Gomez-Ruiz, Santiago, Žižak, Željko S., Steinborn, Dirk, Schmidt, Harry, Paschke, Reinhard, Juranić, Zorica D., Sabo, Tibor, "Palladium(II) complexes with R(2)edda-derived ligands. Part II. Synthesis, characterization and in vitro antitumoral studies of R(2)eddip esters and palladium(II) complexes" in European Journal of Medicinal Chemistry, 44, no. 9 (2009):3452-3458,
https://doi.org/10.1016/j.ejmech.2009.02.002 . .

TY  - JOUR
AU  - Milić, Dragana
AU  - Kop, Tatjana
AU  - Csanadi, Janos
AU  - Juranić, Zorica D.
AU  - Žižak, Željko S.
AU  - Gasic, Miroslav J.
AU  - Šolaja, Bogdan A.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1020
AB  - A simple approach to a stable steroidal estrone derived A.B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac(2)O-TMSOTf system at the ambient temperature led to acetylation, while at the reflux temperature the acid-catalysed rearrangement took place affording the spiro-compound. Results of extensive in vitro and in vivo anticancer tests on the diepoxide, as well as preliminary data on the anti proliferative activity of the spiro-product against three cancer cell lines, are also presented. (C) 2009 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Steroids
T1  - Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system
VL  - 74
IS  - 12
SP  - 890
EP  - 895
DO  - 10.1016/j.steroids.2009.06.002
ER  - 

@article{
author = "Milić, Dragana and Kop, Tatjana and Csanadi, Janos and Juranić, Zorica D. and Žižak, Željko S. and Gasic, Miroslav J. and Šolaja, Bogdan A.",
year = "2009",
abstract = "A simple approach to a stable steroidal estrone derived A.B-spiro system is reported. Treatment of estrone derived A-ring diepoxyalcohol with the Ac(2)O-TMSOTf system at the ambient temperature led to acetylation, while at the reflux temperature the acid-catalysed rearrangement took place affording the spiro-compound. Results of extensive in vitro and in vivo anticancer tests on the diepoxide, as well as preliminary data on the anti proliferative activity of the spiro-product against three cancer cell lines, are also presented. (C) 2009 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Steroids",
title = "Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system",
volume = "74",
number = "12",
pages = "890-895",
doi = "10.1016/j.steroids.2009.06.002"
}

Milić, D., Kop, T., Csanadi, J., Juranić, Z. D., Žižak, Ž. S., Gasic, M. J.,& Šolaja, B. A.. (2009). Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system. in Steroids
Elsevier Science Inc, New York., 74(12), 890-895.
https://doi.org/10.1016/j.steroids.2009.06.002

Milić D, Kop T, Csanadi J, Juranić ZD, Žižak ŽS, Gasic MJ, Šolaja BA. Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system. in Steroids. 2009;74(12):890-895.
doi:10.1016/j.steroids.2009.06.002 .

Milić, Dragana, Kop, Tatjana, Csanadi, Janos, Juranić, Zorica D., Žižak, Željko S., Gasic, Miroslav J., Šolaja, Bogdan A., "Estrone derived steroidal diepoxide: Biologically active compound and precursor of a stable steroidal A,B-spiro system" in Steroids, 74, no. 12 (2009):890-895,
https://doi.org/10.1016/j.steroids.2009.06.002 . .

TY  - JOUR
AU  - Drakulić, Branko J.
AU  - Stavri, Michael
AU  - Gibbons, Simon
AU  - Žižak, Željko S.
AU  - Verbić, Tatjana
AU  - Jiranic, Ivan O.
AU  - Zloh, Mire
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1037
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - ChemMedChem
T1  - Aryldiketo Acids Have Antibacterial Activity Against MDR Staphylococcus aureus Strains: Structural Insights Based on Similarity and Molecular Interaction Fields
VL  - 4
IS  - 12
SP  - 1971
EP  - 1975
DO  - 10.1002/cmdc.200900273
ER  - 

@article{
author = "Drakulić, Branko J. and Stavri, Michael and Gibbons, Simon and Žižak, Željko S. and Verbić, Tatjana and Jiranic, Ivan O. and Zloh, Mire",
year = "2009",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "ChemMedChem",
title = "Aryldiketo Acids Have Antibacterial Activity Against MDR Staphylococcus aureus Strains: Structural Insights Based on Similarity and Molecular Interaction Fields",
volume = "4",
number = "12",
pages = "1971-1975",
doi = "10.1002/cmdc.200900273"
}

Drakulić, B. J., Stavri, M., Gibbons, S., Žižak, Ž. S., Verbić, T., Jiranic, I. O.,& Zloh, M.. (2009). Aryldiketo Acids Have Antibacterial Activity Against MDR Staphylococcus aureus Strains: Structural Insights Based on Similarity and Molecular Interaction Fields. in ChemMedChem
Wiley-V C H Verlag Gmbh, Weinheim., 4(12), 1971-1975.
https://doi.org/10.1002/cmdc.200900273

Drakulić BJ, Stavri M, Gibbons S, Žižak ŽS, Verbić T, Jiranic IO, Zloh M. Aryldiketo Acids Have Antibacterial Activity Against MDR Staphylococcus aureus Strains: Structural Insights Based on Similarity and Molecular Interaction Fields. in ChemMedChem. 2009;4(12):1971-1975.
doi:10.1002/cmdc.200900273 .

Drakulić, Branko J., Stavri, Michael, Gibbons, Simon, Žižak, Željko S., Verbić, Tatjana, Jiranic, Ivan O., Zloh, Mire, "Aryldiketo Acids Have Antibacterial Activity Against MDR Staphylococcus aureus Strains: Structural Insights Based on Similarity and Molecular Interaction Fields" in ChemMedChem, 4, no. 12 (2009):1971-1975,
https://doi.org/10.1002/cmdc.200900273 . .

TY  - JOUR
AU  - Krajcinovic, Bojana B.
AU  - Kaluđerović, Goran N.
AU  - Steinborn, Dirk
AU  - Schmidt, Harry
AU  - Wagner, Christoph
AU  - Žižak, Željko S.
AU  - Juranić, Zorica D.
AU  - Trifunović, Srećko R.
AU  - Sabo, Tibor
PY  - 2008
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/932
AB  - Syntheses of two novel ligand precursors O,O'-diisopropyl- (1a) and O,O'-diisobutyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride monohydrate (1b) and the corresponding dichloroplatinum(II) (2a and 2b) and tetrachloroplatinum(IV) complexes (3a and 3b) are described here. The substances were characterized by IR, H-1 and C-13 spectroscopy and elemental analysis. Crystal structures were determined for la and the corresponding platinum(IV) complex, 3a. In vitro antiproliferative activity was determined against tumor cell lines: human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x, rested and stimulated normal immunocompetent cells (human peripheral blood mononuclear PBMC cells) using KBR test (Kenacid Blue Dye binding test). The IC50(mu M) values for the most active compound 3a were: 30.48 +/- 2.54; 12.26 +/- 2.60; 13.68 +/- 3.22; 80.18 +/- 24.07 and 71.30 +/- 21.70, respectively. (C) 2008 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis and in vitro antitumoral activity of novel O,O '-di-2-alkyl-(S,S)-ethylenediamine-N,N '-di-2-propanoate ligands and corresponding platinum(II/IV) complexes
VL  - 102
IS  - 4
SP  - 892
EP  - 900
DO  - 10.1016/j.jinorgbio.2007.12.009
ER  - 

@article{
author = "Krajcinovic, Bojana B. and Kaluđerović, Goran N. and Steinborn, Dirk and Schmidt, Harry and Wagner, Christoph and Žižak, Željko S. and Juranić, Zorica D. and Trifunović, Srećko R. and Sabo, Tibor",
year = "2008",
abstract = "Syntheses of two novel ligand precursors O,O'-diisopropyl- (1a) and O,O'-diisobutyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride monohydrate (1b) and the corresponding dichloroplatinum(II) (2a and 2b) and tetrachloroplatinum(IV) complexes (3a and 3b) are described here. The substances were characterized by IR, H-1 and C-13 spectroscopy and elemental analysis. Crystal structures were determined for la and the corresponding platinum(IV) complex, 3a. In vitro antiproliferative activity was determined against tumor cell lines: human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x, rested and stimulated normal immunocompetent cells (human peripheral blood mononuclear PBMC cells) using KBR test (Kenacid Blue Dye binding test). The IC50(mu M) values for the most active compound 3a were: 30.48 +/- 2.54; 12.26 +/- 2.60; 13.68 +/- 3.22; 80.18 +/- 24.07 and 71.30 +/- 21.70, respectively. (C) 2008 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis and in vitro antitumoral activity of novel O,O '-di-2-alkyl-(S,S)-ethylenediamine-N,N '-di-2-propanoate ligands and corresponding platinum(II/IV) complexes",
volume = "102",
number = "4",
pages = "892-900",
doi = "10.1016/j.jinorgbio.2007.12.009"
}

Krajcinovic, B. B., Kaluđerović, G. N., Steinborn, D., Schmidt, H., Wagner, C., Žižak, Ž. S., Juranić, Z. D., Trifunović, S. R.,& Sabo, T.. (2008). Synthesis and in vitro antitumoral activity of novel O,O '-di-2-alkyl-(S,S)-ethylenediamine-N,N '-di-2-propanoate ligands and corresponding platinum(II/IV) complexes. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 102(4), 892-900.
https://doi.org/10.1016/j.jinorgbio.2007.12.009

Krajcinovic BB, Kaluđerović GN, Steinborn D, Schmidt H, Wagner C, Žižak ŽS, Juranić ZD, Trifunović SR, Sabo T. Synthesis and in vitro antitumoral activity of novel O,O '-di-2-alkyl-(S,S)-ethylenediamine-N,N '-di-2-propanoate ligands and corresponding platinum(II/IV) complexes. in Journal of Inorganic Biochemistry. 2008;102(4):892-900.
doi:10.1016/j.jinorgbio.2007.12.009 .

Krajcinovic, Bojana B., Kaluđerović, Goran N., Steinborn, Dirk, Schmidt, Harry, Wagner, Christoph, Žižak, Željko S., Juranić, Zorica D., Trifunović, Srećko R., Sabo, Tibor, "Synthesis and in vitro antitumoral activity of novel O,O '-di-2-alkyl-(S,S)-ethylenediamine-N,N '-di-2-propanoate ligands and corresponding platinum(II/IV) complexes" in Journal of Inorganic Biochemistry, 102, no. 4 (2008):892-900,
https://doi.org/10.1016/j.jinorgbio.2007.12.009 . .

TY  - JOUR
AU  - Gomez-Ruiz, Santiago
AU  - Kaluđerović, Goran N.
AU  - Prashar, Sanjiv
AU  - Polo-Ceron, Dorian
AU  - Fajardo, Mariano
AU  - Žižak, Željko S.
AU  - Sabo, Tibor
AU  - Juranić, Zorica D.
PY  - 2008
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/959
AB  - A variety of substituted titanocene and ansa-titanocene complexes have been synthesized and characterized using traditional methods. The cytotoxic activity of the different titanocene complexes was tested against tumour cell lines human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear cells PBMC. Alkenyl substitution, either on the cyclopentadienyl ring or on the silicon-atom ansa-bridge of the titanocene compounds [Ti{Me2Si(eta(5)-C5Me4) (eta(5)-C5H3{CMe2CH2CH2CH=CH2})}Cl-2] (8), [Ti{Me(CH2=CH)Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (9) and [Ti(eta(5)- C5H4{CMe2CH2CH2CH=CH2})(2)Cl-2] (12) showed higher cytotoxic activities (IC50 values from 24 +/- 3 to 151 +/- 10 mu M) relative to complexes bearing an additional alkenyl-substituted silyl substituent on the silicon bridge [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (10) and [Ti{Me{(CH2=CH)(3)SiCH2CH2} Si(eta(5)-C5Me4)(eta(5) -C5H4)}Cl-2] (11) which causes a dramatic decrease of the cytotoxicity (IC50 values from 155 +/- 9 to  gt  200 mu M). In addition, the synthesis of the analogous niobocene complex [Nb(eta(5)- C5H4{CMe2CH2CH2CH=CH2})(2)Cl-2] (13), is described. Structural studies based on DFT calculations of the most active complexes 8, 9 and 12 and the X-ray crystal structure of 13 are reported. (c) 2008 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs
VL  - 102
IS  - 8
SP  - 1558
EP  - 1570
DO  - 10.1016/j.jinorgbio.2008.02.001
ER  - 

@article{
author = "Gomez-Ruiz, Santiago and Kaluđerović, Goran N. and Prashar, Sanjiv and Polo-Ceron, Dorian and Fajardo, Mariano and Žižak, Željko S. and Sabo, Tibor and Juranić, Zorica D.",
year = "2008",
abstract = "A variety of substituted titanocene and ansa-titanocene complexes have been synthesized and characterized using traditional methods. The cytotoxic activity of the different titanocene complexes was tested against tumour cell lines human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, peripheral blood mononuclear cells PBMC. Alkenyl substitution, either on the cyclopentadienyl ring or on the silicon-atom ansa-bridge of the titanocene compounds [Ti{Me2Si(eta(5)-C5Me4) (eta(5)-C5H3{CMe2CH2CH2CH=CH2})}Cl-2] (8), [Ti{Me(CH2=CH)Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (9) and [Ti(eta(5)- C5H4{CMe2CH2CH2CH=CH2})(2)Cl-2] (12) showed higher cytotoxic activities (IC50 values from 24 +/- 3 to 151 +/- 10 mu M) relative to complexes bearing an additional alkenyl-substituted silyl substituent on the silicon bridge [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (10) and [Ti{Me{(CH2=CH)(3)SiCH2CH2} Si(eta(5)-C5Me4)(eta(5) -C5H4)}Cl-2] (11) which causes a dramatic decrease of the cytotoxicity (IC50 values from 155 +/- 9 to  gt  200 mu M). In addition, the synthesis of the analogous niobocene complex [Nb(eta(5)- C5H4{CMe2CH2CH2CH=CH2})(2)Cl-2] (13), is described. Structural studies based on DFT calculations of the most active complexes 8, 9 and 12 and the X-ray crystal structure of 13 are reported. (c) 2008 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs",
volume = "102",
number = "8",
pages = "1558-1570",
doi = "10.1016/j.jinorgbio.2008.02.001"
}

Gomez-Ruiz, S., Kaluđerović, G. N., Prashar, S., Polo-Ceron, D., Fajardo, M., Žižak, Ž. S., Sabo, T.,& Juranić, Z. D.. (2008). Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 102(8), 1558-1570.
https://doi.org/10.1016/j.jinorgbio.2008.02.001

Gomez-Ruiz S, Kaluđerović GN, Prashar S, Polo-Ceron D, Fajardo M, Žižak ŽS, Sabo T, Juranić ZD. Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs. in Journal of Inorganic Biochemistry. 2008;102(8):1558-1570.
doi:10.1016/j.jinorgbio.2008.02.001 .

Gomez-Ruiz, Santiago, Kaluđerović, Goran N., Prashar, Sanjiv, Polo-Ceron, Dorian, Fajardo, Mariano, Žižak, Željko S., Sabo, Tibor, Juranić, Zorica D., "Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs" in Journal of Inorganic Biochemistry, 102, no. 8 (2008):1558-1570,
https://doi.org/10.1016/j.jinorgbio.2008.02.001 . .

TY  - JOUR
AU  - Grgurić-Šipka, Sanja
AU  - Alshtewi, Mohamed Al. Arbi M.
AU  - Jeremić, Dejan
AU  - Kaluđerović, Goran N.
AU  - Gomez-Ruiz, Santiago
AU  - Žižak, Željko S.
AU  - Juranić, Zorica D.
AU  - Sabo, Tibor
PY  - 2008
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/966
AB  - Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(eta(6)-p-cymene)RuCl2(CH3NH(CH2)(4)NH)]PF6, complex 1) or vitamin K-3-thiosemicarbazone ([(eta(6)-p-cymene)RuCl2(K(3)tsc)], complex 2) were synthesized starting from [(eta(6)-p-cymene)(2)RuCl2](2) and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand present.
AB  - Sintetisana su dva nova p-cimen-rutenijum(II) kompleksa koji sadrže kao dodatne ligande N-metilpiperazin ([(h6-p-cimen)RuCl2(CH3NH(CH2)4NH)]PF6, kompleks 1) i vitamin K3-tiosemikarbazon ([(h6-p-cimen)RuCl2(K3tsc)], kompleks 2). Oba nova kompleksa dobijena su polazeći od [(h6-p-cimen)2RuCl2]2 kompleksa i odgovarajućeg liganda. Kompleksi su okarakterisani elementalnom analizom, IC, elektronsko-apsorpcionom i NMR spektroskopijom. Rendgeno-strukturna analiza kompleksa 1 pokazala je “piano-stool” geometriju. U zavisnosti od prisutnog liganda diskutovana je razlika u citotoksičnoj aktivnosti ova dva dobijena kompleksa.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes
T1  - Sinteza, strukturna karakterizacija i citotoksična aktivnost dva nova organorutenijum(II) kompleksa
VL  - 73
IS  - 6
SP  - 619
EP  - 630
DO  - 10.2298/JSC0806619G
ER  - 

@article{
author = "Grgurić-Šipka, Sanja and Alshtewi, Mohamed Al. Arbi M. and Jeremić, Dejan and Kaluđerović, Goran N. and Gomez-Ruiz, Santiago and Žižak, Željko S. and Juranić, Zorica D. and Sabo, Tibor",
year = "2008",
abstract = "Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine ([(eta(6)-p-cymene)RuCl2(CH3NH(CH2)(4)NH)]PF6, complex 1) or vitamin K-3-thiosemicarbazone ([(eta(6)-p-cymene)RuCl2(K(3)tsc)], complex 2) were synthesized starting from [(eta(6)-p-cymene)(2)RuCl2](2) and the corresponding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure determination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand present., Sintetisana su dva nova p-cimen-rutenijum(II) kompleksa koji sadrže kao dodatne ligande N-metilpiperazin ([(h6-p-cimen)RuCl2(CH3NH(CH2)4NH)]PF6, kompleks 1) i vitamin K3-tiosemikarbazon ([(h6-p-cimen)RuCl2(K3tsc)], kompleks 2). Oba nova kompleksa dobijena su polazeći od [(h6-p-cimen)2RuCl2]2 kompleksa i odgovarajućeg liganda. Kompleksi su okarakterisani elementalnom analizom, IC, elektronsko-apsorpcionom i NMR spektroskopijom. Rendgeno-strukturna analiza kompleksa 1 pokazala je “piano-stool” geometriju. U zavisnosti od prisutnog liganda diskutovana je razlika u citotoksičnoj aktivnosti ova dva dobijena kompleksa.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes, Sinteza, strukturna karakterizacija i citotoksična aktivnost dva nova organorutenijum(II) kompleksa",
volume = "73",
number = "6",
pages = "619-630",
doi = "10.2298/JSC0806619G"
}

Grgurić-Šipka, S., Alshtewi, M. Al. A. M., Jeremić, D., Kaluđerović, G. N., Gomez-Ruiz, S., Žižak, Ž. S., Juranić, Z. D.,& Sabo, T.. (2008). Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 73(6), 619-630.
https://doi.org/10.2298/JSC0806619G

Grgurić-Šipka S, Alshtewi MAAM, Jeremić D, Kaluđerović GN, Gomez-Ruiz S, Žižak ŽS, Juranić ZD, Sabo T. Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes. in Journal of the Serbian Chemical Society. 2008;73(6):619-630.
doi:10.2298/JSC0806619G .

Grgurić-Šipka, Sanja, Alshtewi, Mohamed Al. Arbi M., Jeremić, Dejan, Kaluđerović, Goran N., Gomez-Ruiz, Santiago, Žižak, Željko S., Juranić, Zorica D., Sabo, Tibor, "Synthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes" in Journal of the Serbian Chemical Society, 73, no. 6 (2008):619-630,
https://doi.org/10.2298/JSC0806619G . .

TY  - CONF
AU  - Žižak, Željko S.
AU  - Opsenica, Dejan M.
AU  - Šolaja, Bogdan A.
AU  - Juranić, Z.
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/884
PB  - Pergamon-Elsevier Science Ltd, Oxford
C3  - European Journal of Cancer Supplements / EJC Supplements
T1  - Investigation of some tetraoxanes as potential antitumour agents
VL  - 5
IS  - 4
SP  - 89
EP  - 89
DO  - 10.1016/S1359-6349(07)70436-6
ER  - 

@conference{
author = "Žižak, Željko S. and Opsenica, Dejan M. and Šolaja, Bogdan A. and Juranić, Z.",
year = "2007",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "European Journal of Cancer Supplements / EJC Supplements",
title = "Investigation of some tetraoxanes as potential antitumour agents",
volume = "5",
number = "4",
pages = "89-89",
doi = "10.1016/S1359-6349(07)70436-6"
}

Žižak, Ž. S., Opsenica, D. M., Šolaja, B. A.,& Juranić, Z.. (2007). Investigation of some tetraoxanes as potential antitumour agents. in European Journal of Cancer Supplements / EJC Supplements
Pergamon-Elsevier Science Ltd, Oxford., 5(4), 89-89.
https://doi.org/10.1016/S1359-6349(07)70436-6

Žižak ŽS, Opsenica DM, Šolaja BA, Juranić Z. Investigation of some tetraoxanes as potential antitumour agents. in European Journal of Cancer Supplements / EJC Supplements. 2007;5(4):89-89.
doi:10.1016/S1359-6349(07)70436-6 .

Žižak, Željko S., Opsenica, Dejan M., Šolaja, Bogdan A., Juranić, Z., "Investigation of some tetraoxanes as potential antitumour agents" in European Journal of Cancer Supplements / EJC Supplements, 5, no. 4 (2007):89-89,
https://doi.org/10.1016/S1359-6349(07)70436-6 . .

TY  - JOUR
AU  - Gomez-Ruiz, Santiago
AU  - Kaluđerović, Goran N.
AU  - Polo-Ceron, Dorian
AU  - Prashar, Sanjiv
AU  - Fajardo, Mariano
AU  - Žižak, Žejko S.
AU  - Juranić, Zorica D.
AU  - Sabo, Tibor
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/847
AB  - The cytotoxic activity on tumour cell lines, human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, was tested for four different ansa-titanocene dichloride derivatives with potentially reactive substituents [Ti{Me{(CH2=CH)Si(eta(5)-Me-5(4)) (eta(5)-C5H4))Cl-2] (1), [Ti{Me(H)Si(eta(5)-C5Me4)(2)}Cl-2] (2), [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (3) and [Ti{Me2Si(eta(5)-C5Me4)(eta(5)-C5H3(CMe2(CH2CH2CH=CH2)))}Cl-2] (4), showing a very promising activity and opening up the possibility of extensive investigation in this field. (c) 2007 Elsevier B.V. All rights reserved.
PB  - Elsevier Science Bv, Amsterdam
T2  - Inorganic Chemistry Communications
T1  - Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes
VL  - 10
IS  - 7
SP  - 748
EP  - 752
DO  - 10.1016/j.inoche.2007.03.016
ER  - 

@article{
author = "Gomez-Ruiz, Santiago and Kaluđerović, Goran N. and Polo-Ceron, Dorian and Prashar, Sanjiv and Fajardo, Mariano and Žižak, Žejko S. and Juranić, Zorica D. and Sabo, Tibor",
year = "2007",
abstract = "The cytotoxic activity on tumour cell lines, human adenocarcinoma HeLa, human myelogenous leukemia K562, human malignant melanoma Fem-x and normal immunocompetent cells, was tested for four different ansa-titanocene dichloride derivatives with potentially reactive substituents [Ti{Me{(CH2=CH)Si(eta(5)-Me-5(4)) (eta(5)-C5H4))Cl-2] (1), [Ti{Me(H)Si(eta(5)-C5Me4)(2)}Cl-2] (2), [Ti{Me{(CH2=CH)Me2SiCH2CH2}Si(eta(5)-C5Me4)(eta(5)-C5H4)}Cl-2] (3) and [Ti{Me2Si(eta(5)-C5Me4)(eta(5)-C5H3(CMe2(CH2CH2CH=CH2)))}Cl-2] (4), showing a very promising activity and opening up the possibility of extensive investigation in this field. (c) 2007 Elsevier B.V. All rights reserved.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Inorganic Chemistry Communications",
title = "Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes",
volume = "10",
number = "7",
pages = "748-752",
doi = "10.1016/j.inoche.2007.03.016"
}

Gomez-Ruiz, S., Kaluđerović, G. N., Polo-Ceron, D., Prashar, S., Fajardo, M., Žižak, Ž. S., Juranić, Z. D.,& Sabo, T.. (2007). Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes. in Inorganic Chemistry Communications
Elsevier Science Bv, Amsterdam., 10(7), 748-752.
https://doi.org/10.1016/j.inoche.2007.03.016

Gomez-Ruiz S, Kaluđerović GN, Polo-Ceron D, Prashar S, Fajardo M, Žižak ŽS, Juranić ZD, Sabo T. Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes. in Inorganic Chemistry Communications. 2007;10(7):748-752.
doi:10.1016/j.inoche.2007.03.016 .

Gomez-Ruiz, Santiago, Kaluđerović, Goran N., Polo-Ceron, Dorian, Prashar, Sanjiv, Fajardo, Mariano, Žižak, Žejko S., Juranić, Zorica D., Sabo, Tibor, "Study of the cytotoxic activity of alkenyl-substituted ansa-titanocene complexes" in Inorganic Chemistry Communications, 10, no. 7 (2007):748-752,
https://doi.org/10.1016/j.inoche.2007.03.016 . .

TY  - JOUR
AU  - Trifunović, Snežana S.
AU  - Vajs, Vlatka
AU  - Juranić, Zorica D.
AU  - Žižak, Željko S.
AU  - Tešević, Vele
AU  - Macura, Slobodan
AU  - Milosavljević, Slobodan M.
PY  - 2006
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/779
AB  - Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Cytotoxic constituents of Achillea clavennae from Montenegro
VL  - 67
IS  - 9
SP  - 887
EP  - 893
DO  - 10.1016/j.phytochem.2006.02.026
ER  - 

@article{
author = "Trifunović, Snežana S. and Vajs, Vlatka and Juranić, Zorica D. and Žižak, Željko S. and Tešević, Vele and Macura, Slobodan and Milosavljević, Slobodan M.",
year = "2006",
abstract = "Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Cytotoxic constituents of Achillea clavennae from Montenegro",
volume = "67",
number = "9",
pages = "887-893",
doi = "10.1016/j.phytochem.2006.02.026"
}

Trifunović, S. S., Vajs, V., Juranić, Z. D., Žižak, Ž. S., Tešević, V., Macura, S.,& Milosavljević, S. M.. (2006). Cytotoxic constituents of Achillea clavennae from Montenegro. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 67(9), 887-893.
https://doi.org/10.1016/j.phytochem.2006.02.026

Trifunović SS, Vajs V, Juranić ZD, Žižak ŽS, Tešević V, Macura S, Milosavljević SM. Cytotoxic constituents of Achillea clavennae from Montenegro. in Phytochemistry. 2006;67(9):887-893.
doi:10.1016/j.phytochem.2006.02.026 .

Trifunović, Snežana S., Vajs, Vlatka, Juranić, Zorica D., Žižak, Željko S., Tešević, Vele, Macura, Slobodan, Milosavljević, Slobodan M., "Cytotoxic constituents of Achillea clavennae from Montenegro" in Phytochemistry, 67, no. 9 (2006):887-893,
https://doi.org/10.1016/j.phytochem.2006.02.026 . .

TY  - CONF
AU  - Žižak, Željko S.
AU  - Kop, Tatjana
AU  - Šolaja, Bogdan A.
AU  - Stanojković, Tatjana
AU  - Juranić, Z.
PY  - 2005
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/844
PB  - Pergamon-Elsevier Science Ltd, Oxford
C3  - European Journal of Cancer Supplements / EJC Supplements
T1  - Investigation of some quinols and epoxyquinols as potential antitumor agents
VL  - 3
IS  - 2
SP  - 63
EP  - 63
UR  - https://hdl.handle.net/21.15107/rcub_cherry_844
ER  - 

@conference{
author = "Žižak, Željko S. and Kop, Tatjana and Šolaja, Bogdan A. and Stanojković, Tatjana and Juranić, Z.",
year = "2005",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "European Journal of Cancer Supplements / EJC Supplements",
title = "Investigation of some quinols and epoxyquinols as potential antitumor agents",
volume = "3",
number = "2",
pages = "63-63",
url = "https://hdl.handle.net/21.15107/rcub_cherry_844"
}

Žižak, Ž. S., Kop, T., Šolaja, B. A., Stanojković, T.,& Juranić, Z.. (2005). Investigation of some quinols and epoxyquinols as potential antitumor agents. in European Journal of Cancer Supplements / EJC Supplements
Pergamon-Elsevier Science Ltd, Oxford., 3(2), 63-63.
https://hdl.handle.net/21.15107/rcub_cherry_844

Žižak ŽS, Kop T, Šolaja BA, Stanojković T, Juranić Z. Investigation of some quinols and epoxyquinols as potential antitumor agents. in European Journal of Cancer Supplements / EJC Supplements. 2005;3(2):63-63.
https://hdl.handle.net/21.15107/rcub_cherry_844 .

Žižak, Željko S., Kop, Tatjana, Šolaja, Bogdan A., Stanojković, Tatjana, Juranić, Z., "Investigation of some quinols and epoxyquinols as potential antitumor agents" in European Journal of Cancer Supplements / EJC Supplements, 3, no. 2 (2005):63-63,
https://hdl.handle.net/21.15107/rcub_cherry_844 .

TY  - JOUR
AU  - Opsenica, Dejan M.
AU  - Angelovski, G
AU  - Pocsfalvi, G
AU  - Juranić, Z.
AU  - Žižak, Željko S.
AU  - Kyle, D
AU  - Milhous, WK
AU  - Šolaja, Bogdan A.
PY  - 2003
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/559
AB  - Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against Plasmodium falciparum D6 and W2 strains. The existence of HN-C(O) moiety was found necessary for pronounced antimalarial and antiproliferative activity. In antiproliferative screen, the trans tetraoxane 6 was found to exhibit a pronounced cytotoxicity on 14 cancer cell lines. In addition, tetraoxanes 11 and 12 exhibited significant cytotoxic activity too; microscopic examination of treated HeLa cells showed morphological appearance reminiscent for apoptosis (condensed and/or fragmented nuclei). (C) 2003 Elsevier Science Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic and Medicinal Chemistry
T1  - Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes
VL  - 11
IS  - 13
SP  - 2761
EP  - 2768
DO  - 10.1016/S0968-0896(03)00224-4
ER  - 

@article{
author = "Opsenica, Dejan M. and Angelovski, G and Pocsfalvi, G and Juranić, Z. and Žižak, Željko S. and Kyle, D and Milhous, WK and Šolaja, Bogdan A.",
year = "2003",
abstract = "Several cis and trans bis-steroidal 1,2,4,5-tetraoxanes possessing amide terminus were synthesised and evaluated as antimalarials and antiproliferatives. The compounds exhibited submicromolar antimalarial activity against Plasmodium falciparum D6 and W2 strains. The existence of HN-C(O) moiety was found necessary for pronounced antimalarial and antiproliferative activity. In antiproliferative screen, the trans tetraoxane 6 was found to exhibit a pronounced cytotoxicity on 14 cancer cell lines. In addition, tetraoxanes 11 and 12 exhibited significant cytotoxic activity too; microscopic examination of treated HeLa cells showed morphological appearance reminiscent for apoptosis (condensed and/or fragmented nuclei). (C) 2003 Elsevier Science Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic and Medicinal Chemistry",
title = "Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes",
volume = "11",
number = "13",
pages = "2761-2768",
doi = "10.1016/S0968-0896(03)00224-4"
}

Opsenica, D. M., Angelovski, G., Pocsfalvi, G., Juranić, Z., Žižak, Ž. S., Kyle, D., Milhous, W.,& Šolaja, B. A.. (2003). Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes. in Bioorganic and Medicinal Chemistry
Pergamon-Elsevier Science Ltd, Oxford., 11(13), 2761-2768.
https://doi.org/10.1016/S0968-0896(03)00224-4

Opsenica DM, Angelovski G, Pocsfalvi G, Juranić Z, Žižak ŽS, Kyle D, Milhous W, Šolaja BA. Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes. in Bioorganic and Medicinal Chemistry. 2003;11(13):2761-2768.
doi:10.1016/S0968-0896(03)00224-4 .

Opsenica, Dejan M., Angelovski, G, Pocsfalvi, G, Juranić, Z., Žižak, Željko S., Kyle, D, Milhous, WK, Šolaja, Bogdan A., "Antimalarial and antiproliferative evaluation of bis-steroidal tetraoxanes" in Bioorganic and Medicinal Chemistry, 11, no. 13 (2003):2761-2768,
https://doi.org/10.1016/S0968-0896(03)00224-4 . .