TY  - JOUR
AU  - Krstić, Gordana B.
AU  - Aljančić, Ivana
AU  - Stanković, Jovana
AU  - Cvetković, Mirjana
AU  - Marin, Petar D.
AU  - Janaćković, Peđa T.
AU  - Tešević, Vele
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3052
AB  - The presence of n-alkanes, free alcohols and free acids in leaf epicuticular wax extracts of 22 samples of 11 Euphorbia L. species belonging to the sections Paralias, Esula, Myrsiniteae and Helioscopia, 10 of which were never examined before, were analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS), and n-alkane C27 was detected as the principal component of leaf epicuticular waxes in the majority of the examined species, while the most abundant free alcohol was C26. Three Euphorbia species belonging to section Helioscopia were characterized by a predominance of alcohol C28. Free acid (C16) was the major component in 21 investigated samples. The usefulness of n-alkanes and free alcohols and free acids as potential chemotaxonomic markers is briefly discussed.
T2  - Archives of Biological Sciences
T1  - Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy
VL  - 71
IS  - 1
SP  - 21
EP  - 26
DO  - 10.2298/ABS180608041K
ER  - 

@article{
author = "Krstić, Gordana B. and Aljančić, Ivana and Stanković, Jovana and Cvetković, Mirjana and Marin, Petar D. and Janaćković, Peđa T. and Tešević, Vele",
year = "2019",
abstract = "The presence of n-alkanes, free alcohols and free acids in leaf epicuticular wax extracts of 22 samples of 11 Euphorbia L. species belonging to the sections Paralias, Esula, Myrsiniteae and Helioscopia, 10 of which were never examined before, were analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS), and n-alkane C27 was detected as the principal component of leaf epicuticular waxes in the majority of the examined species, while the most abundant free alcohol was C26. Three Euphorbia species belonging to section Helioscopia were characterized by a predominance of alcohol C28. Free acid (C16) was the major component in 21 investigated samples. The usefulness of n-alkanes and free alcohols and free acids as potential chemotaxonomic markers is briefly discussed.",
journal = "Archives of Biological Sciences",
title = "Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy",
volume = "71",
number = "1",
pages = "21-26",
doi = "10.2298/ABS180608041K"
}

Krstić, G. B., Aljančić, I., Stanković, J., Cvetković, M., Marin, P. D., Janaćković, P. T.,& Tešević, V.. (2019). Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy. in Archives of Biological Sciences, 71(1), 21-26.
https://doi.org/10.2298/ABS180608041K

Krstić GB, Aljančić I, Stanković J, Cvetković M, Marin PD, Janaćković PT, Tešević V. Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy. in Archives of Biological Sciences. 2019;71(1):21-26.
doi:10.2298/ABS180608041K .

Krstić, Gordana B., Aljančić, Ivana, Stanković, Jovana, Cvetković, Mirjana, Marin, Petar D., Janaćković, Peđa T., Tešević, Vele, "Leaf epicuticular waxes of eleven Euphorbia species (Euphorbiaceae) from the central Balkans: Impact on chemotaxonomy" in Archives of Biological Sciences, 71, no. 1 (2019):21-26,
https://doi.org/10.2298/ABS180608041K . .

TY  - JOUR
AU  - Krstić, Gordana B.
AU  - Jadranin, Milka
AU  - Stanković, Miroslava
AU  - Aljančić, Ivana
AU  - Vujisić, Ljubodrag V.
AU  - Mandić, Boris
AU  - Tešević, Vele
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3143
AB  - Two sets of structurally different jatrophanes (1-11 and 13-16), jatrophane 12, and latex extract of 2 Euphorbia species (17 and 18) were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes using the cytokinesis-block micronucleus (CBMN) assay. Jatrophanes 1-6 in minimal doses of 1 µg/mL prominently decreased micronuclei (MN) frequency in the range 44.86% to 34.29% and manifested considerable protective effect. From the other set of jatrophanes, 13 in the same minimal dose notably decreased MN frequency by 31.05%, while extracts 17 and 18 at a concentration of 4 µg/mL remarkably decreased the frequency of MN by 37.94% and 36.12%, respectively. Jatrophanes 12, 14, and 16 showed moderate protection, while 7-11 and 15 were less active than positive control. The structure-activity relationship (SAR) studies of the tested jatrophanes (1-16) indicated the favorable position of benzoate at C-8 or C-9 (3, 4, and 13) and a preference of isobutanoyloxy group at C-3 (1-3) rather than propanoyloxy at the same position (4-6) for pronounced protective effect on human lymphocytes DNA. In a previous SAR study on 11 jatrophanes (1, 3-8, and 13-16), the same structural features in 3, 4, and 13 influenced powerful inhibition of P-gp, while growth inhibition of cancer cells was more than doubled in 1 (isobutanoyloxy group at C-3) compared to 6 (propanoyloxy at C-3).
PB  - SAGE Journals
T2  - Natural Product Communications
T1  - Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA
VL  - 14
IS  - 5
DO  - 10.1177/1934578X19848168
ER  - 

@article{
author = "Krstić, Gordana B. and Jadranin, Milka and Stanković, Miroslava and Aljančić, Ivana and Vujisić, Ljubodrag V. and Mandić, Boris and Tešević, Vele",
year = "2019",
abstract = "Two sets of structurally different jatrophanes (1-11 and 13-16), jatrophane 12, and latex extract of 2 Euphorbia species (17 and 18) were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes using the cytokinesis-block micronucleus (CBMN) assay. Jatrophanes 1-6 in minimal doses of 1 µg/mL prominently decreased micronuclei (MN) frequency in the range 44.86% to 34.29% and manifested considerable protective effect. From the other set of jatrophanes, 13 in the same minimal dose notably decreased MN frequency by 31.05%, while extracts 17 and 18 at a concentration of 4 µg/mL remarkably decreased the frequency of MN by 37.94% and 36.12%, respectively. Jatrophanes 12, 14, and 16 showed moderate protection, while 7-11 and 15 were less active than positive control. The structure-activity relationship (SAR) studies of the tested jatrophanes (1-16) indicated the favorable position of benzoate at C-8 or C-9 (3, 4, and 13) and a preference of isobutanoyloxy group at C-3 (1-3) rather than propanoyloxy at the same position (4-6) for pronounced protective effect on human lymphocytes DNA. In a previous SAR study on 11 jatrophanes (1, 3-8, and 13-16), the same structural features in 3, 4, and 13 influenced powerful inhibition of P-gp, while growth inhibition of cancer cells was more than doubled in 1 (isobutanoyloxy group at C-3) compared to 6 (propanoyloxy at C-3).",
publisher = "SAGE Journals",
journal = "Natural Product Communications",
title = "Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA",
volume = "14",
number = "5",
doi = "10.1177/1934578X19848168"
}

Krstić, G. B., Jadranin, M., Stanković, M., Aljančić, I., Vujisić, L. V., Mandić, B.,& Tešević, V.. (2019). Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA. in Natural Product Communications
SAGE Journals., 14(5).
https://doi.org/10.1177/1934578X19848168

Krstić GB, Jadranin M, Stanković M, Aljančić I, Vujisić LV, Mandić B, Tešević V. Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA. in Natural Product Communications. 2019;14(5).
doi:10.1177/1934578X19848168 .

Krstić, Gordana B., Jadranin, Milka, Stanković, Miroslava, Aljančić, Ivana, Vujisić, Ljubodrag V., Mandić, Boris, Tešević, Vele, "Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA" in Natural Product Communications, 14, no. 5 (2019),
https://doi.org/10.1177/1934578X19848168 . .

TY  - JOUR
AU  - Krstić, Gordana B.
AU  - Jadranin, Milka
AU  - Todorović, Nina
AU  - Pešić, Milica
AU  - Stanković, Tijana
AU  - Aljančić, Ivana
AU  - Tešević, Vele
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2108
AB  - Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER. (C) 2018 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis
VL  - 148
SP  - 104
EP  - 112
DO  - 10.1016/j.phytochem.2018.01.016
ER  - 

@article{
author = "Krstić, Gordana B. and Jadranin, Milka and Todorović, Nina and Pešić, Milica and Stanković, Tijana and Aljančić, Ivana and Tešević, Vele",
year = "2018",
abstract = "Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectro-scopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/12 and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER. (C) 2018 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis",
volume = "148",
pages = "104-112",
doi = "10.1016/j.phytochem.2018.01.016"
}

Krstić, G. B., Jadranin, M., Todorović, N., Pešić, M., Stanković, T., Aljančić, I.,& Tešević, V.. (2018). Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 148, 104-112.
https://doi.org/10.1016/j.phytochem.2018.01.016

Krstić GB, Jadranin M, Todorović N, Pešić M, Stanković T, Aljančić I, Tešević V. Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis. in Phytochemistry. 2018;148:104-112.
doi:10.1016/j.phytochem.2018.01.016 .

Krstić, Gordana B., Jadranin, Milka, Todorović, Nina, Pešić, Milica, Stanković, Tijana, Aljančić, Ivana, Tešević, Vele, "Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis" in Phytochemistry, 148 (2018):104-112,
https://doi.org/10.1016/j.phytochem.2018.01.016 . .

TY  - DATA
AU  - Krstić, Gordana B.
AU  - Jadranin, Milka
AU  - Todorović, Nina
AU  - Pešić, Milica
AU  - Stanković, Tijana
AU  - Aljančić, Ivana
AU  - Tešević, Vele
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3234
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Supplementary material for the article: Krstić, G.; Jadranin, M.; Todorović, N. M.; Pešić, M.; Stanković, T.; Aljančić, I. S.; Tešević, V. V. Jatrophane Diterpenoids with Multidrug-Resistance Modulating Activity from the Latex of Euphorbia Nicaeensis. Phytochemistry 2018, 148, 104–112. https://doi.org/10.1016/j.phytochem.2018.01.016
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3234
ER  - 

@misc{
author = "Krstić, Gordana B. and Jadranin, Milka and Todorović, Nina and Pešić, Milica and Stanković, Tijana and Aljančić, Ivana and Tešević, Vele",
year = "2018",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Supplementary material for the article: Krstić, G.; Jadranin, M.; Todorović, N. M.; Pešić, M.; Stanković, T.; Aljančić, I. S.; Tešević, V. V. Jatrophane Diterpenoids with Multidrug-Resistance Modulating Activity from the Latex of Euphorbia Nicaeensis. Phytochemistry 2018, 148, 104–112. https://doi.org/10.1016/j.phytochem.2018.01.016",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3234"
}

Krstić, G. B., Jadranin, M., Todorović, N., Pešić, M., Stanković, T., Aljančić, I.,& Tešević, V.. (2018). Supplementary material for the article: Krstić, G.; Jadranin, M.; Todorović, N. M.; Pešić, M.; Stanković, T.; Aljančić, I. S.; Tešević, V. V. Jatrophane Diterpenoids with Multidrug-Resistance Modulating Activity from the Latex of Euphorbia Nicaeensis. Phytochemistry 2018, 148, 104–112. https://doi.org/10.1016/j.phytochem.2018.01.016. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford..
https://hdl.handle.net/21.15107/rcub_cherry_3234

Krstić GB, Jadranin M, Todorović N, Pešić M, Stanković T, Aljančić I, Tešević V. Supplementary material for the article: Krstić, G.; Jadranin, M.; Todorović, N. M.; Pešić, M.; Stanković, T.; Aljančić, I. S.; Tešević, V. V. Jatrophane Diterpenoids with Multidrug-Resistance Modulating Activity from the Latex of Euphorbia Nicaeensis. Phytochemistry 2018, 148, 104–112. https://doi.org/10.1016/j.phytochem.2018.01.016. in Phytochemistry. 2018;.
https://hdl.handle.net/21.15107/rcub_cherry_3234 .

Krstić, Gordana B., Jadranin, Milka, Todorović, Nina, Pešić, Milica, Stanković, Tijana, Aljančić, Ivana, Tešević, Vele, "Supplementary material for the article: Krstić, G.; Jadranin, M.; Todorović, N. M.; Pešić, M.; Stanković, T.; Aljančić, I. S.; Tešević, V. V. Jatrophane Diterpenoids with Multidrug-Resistance Modulating Activity from the Latex of Euphorbia Nicaeensis. Phytochemistry 2018, 148, 104–112. https://doi.org/10.1016/j.phytochem.2018.01.016" in Phytochemistry (2018),
https://hdl.handle.net/21.15107/rcub_cherry_3234 .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vučković, Ivan M.
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Đorđević, Iris
AU  - Podolski-Renić, Ana
AU  - Stojković, Sonja
AU  - Menkovic, Nebojsa
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1500
AB  - Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. (C) 2013 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines
VL  - 98
SP  - 190
EP  - 196
DO  - 10.1016/j.phytochem.2013.11.025
ER  - 

@article{
author = "Aljančić, Ivana and Vučković, Ivan M. and Jadranin, Milka and Pešić, Milica and Đorđević, Iris and Podolski-Renić, Ana and Stojković, Sonja and Menkovic, Nebojsa and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2014",
abstract = "Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. (C) 2013 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines",
volume = "98",
pages = "190-196",
doi = "10.1016/j.phytochem.2013.11.025"
}

Aljančić, I., Vučković, I. M., Jadranin, M., Pešić, M., Đorđević, I., Podolski-Renić, A., Stojković, S., Menkovic, N., Vajs, V.,& Milosavljević, S. M.. (2014). Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 98, 190-196.
https://doi.org/10.1016/j.phytochem.2013.11.025

Aljančić I, Vučković IM, Jadranin M, Pešić M, Đorđević I, Podolski-Renić A, Stojković S, Menkovic N, Vajs V, Milosavljević SM. Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry. 2014;98:190-196.
doi:10.1016/j.phytochem.2013.11.025 .

Aljančić, Ivana, Vučković, Ivan M., Jadranin, Milka, Pešić, Milica, Đorđević, Iris, Podolski-Renić, Ana, Stojković, Sonja, Menkovic, Nebojsa, Vajs, Vlatka, Milosavljević, Slobodan M., "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines" in Phytochemistry, 98 (2014):190-196,
https://doi.org/10.1016/j.phytochem.2013.11.025 . .

TY  - JOUR
AU  - Tešević, Vele
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan M.
AU  - Vajs, Vlatka
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Menkovic, Nebojsa
AU  - Matevski, Vlado
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1890
AB  - The aerial parts of three endemic Centaurea L. species, namely C. tomorosii Micevski, C. soskae Hayek and C. galicicae Micevski, afforded the sesquiterpene lactone cnicin (1) and seven flavonoids: apigenin (2), isokaempferide (3), hispidulin (4), eupatorin (5), cirsimaritin (6), santoflavone (7) and salvigenin (8). The structures of the isolated compounds were determined by UV, H-1-NMR and C-13-NMR spectroscopy and HR-ESI-MS spectrometry. H-1-NMR spectroscopy was used as a method for the quantitative analysis of cnicin.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Secondary metabolites of three endemic Centaurea L. species
VL  - 79
IS  - 11
SP  - 1355
EP  - 1362
DO  - 10.2298/JSC140318048T
ER  - 

@article{
author = "Tešević, Vele and Aljančić, Ivana and Milosavljević, Slobodan M. and Vajs, Vlatka and Đorđević, Iris and Jadranin, Milka and Menkovic, Nebojsa and Matevski, Vlado",
year = "2014",
abstract = "The aerial parts of three endemic Centaurea L. species, namely C. tomorosii Micevski, C. soskae Hayek and C. galicicae Micevski, afforded the sesquiterpene lactone cnicin (1) and seven flavonoids: apigenin (2), isokaempferide (3), hispidulin (4), eupatorin (5), cirsimaritin (6), santoflavone (7) and salvigenin (8). The structures of the isolated compounds were determined by UV, H-1-NMR and C-13-NMR spectroscopy and HR-ESI-MS spectrometry. H-1-NMR spectroscopy was used as a method for the quantitative analysis of cnicin.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Secondary metabolites of three endemic Centaurea L. species",
volume = "79",
number = "11",
pages = "1355-1362",
doi = "10.2298/JSC140318048T"
}

Tešević, V., Aljančić, I., Milosavljević, S. M., Vajs, V., Đorđević, I., Jadranin, M., Menkovic, N.,& Matevski, V.. (2014). Secondary metabolites of three endemic Centaurea L. species. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(11), 1355-1362.
https://doi.org/10.2298/JSC140318048T

Tešević V, Aljančić I, Milosavljević SM, Vajs V, Đorđević I, Jadranin M, Menkovic N, Matevski V. Secondary metabolites of three endemic Centaurea L. species. in Journal of the Serbian Chemical Society. 2014;79(11):1355-1362.
doi:10.2298/JSC140318048T .

Tešević, Vele, Aljančić, Ivana, Milosavljević, Slobodan M., Vajs, Vlatka, Đorđević, Iris, Jadranin, Milka, Menkovic, Nebojsa, Matevski, Vlado, "Secondary metabolites of three endemic Centaurea L. species" in Journal of the Serbian Chemical Society, 79, no. 11 (2014):1355-1362,
https://doi.org/10.2298/JSC140318048T . .

TY  - JOUR
AU  - Tešević, Vele
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Živković, Marijana B.
AU  - Nikićević, Ninoslav
AU  - Urosevic, Ivan
AU  - Vujisić, Ljubodrag V.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1648
AB  - An ultra-performance liquid chromatographic triple quadrupole mass spectrometric (UPLC-QqQ-MS/MS) method with a multiple reactions monitoring mode (MRM) was developed and validated for the quantification of vanillin and syringaldehyde in plum brandy. The method showed good linearity (0.05 to 10 mg L-1) and low limits of detection and quantification (the LOD and LOQ values were 11.6 and 38.2 mu g L-1 for vanillin, and 12.7 and 42.0 mu g L-1 for syringaldehyde, respectively). The overall intra-day and inter-day variations were less than 4.21 % and the overall recovery was over 93.0 %. The correlation coefficients (R-2) of the calibration curves were higher than 0.9999. In order to evaluate whether the method was suitable for use as a routine analytical tool, vanillin and syringaldehyde were determined in 31 samples of Serbian plum brandy.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies
VL  - 79
IS  - 12
SP  - 1537
EP  - 1543
DO  - 10.2298/JSC140225079T
ER  - 

@article{
author = "Tešević, Vele and Aljančić, Ivana and Vajs, Vlatka and Živković, Marijana B. and Nikićević, Ninoslav and Urosevic, Ivan and Vujisić, Ljubodrag V.",
year = "2014",
abstract = "An ultra-performance liquid chromatographic triple quadrupole mass spectrometric (UPLC-QqQ-MS/MS) method with a multiple reactions monitoring mode (MRM) was developed and validated for the quantification of vanillin and syringaldehyde in plum brandy. The method showed good linearity (0.05 to 10 mg L-1) and low limits of detection and quantification (the LOD and LOQ values were 11.6 and 38.2 mu g L-1 for vanillin, and 12.7 and 42.0 mu g L-1 for syringaldehyde, respectively). The overall intra-day and inter-day variations were less than 4.21 % and the overall recovery was over 93.0 %. The correlation coefficients (R-2) of the calibration curves were higher than 0.9999. In order to evaluate whether the method was suitable for use as a routine analytical tool, vanillin and syringaldehyde were determined in 31 samples of Serbian plum brandy.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies",
volume = "79",
number = "12",
pages = "1537-1543",
doi = "10.2298/JSC140225079T"
}

Tešević, V., Aljančić, I., Vajs, V., Živković, M. B., Nikićević, N., Urosevic, I.,& Vujisić, L. V.. (2014). Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(12), 1537-1543.
https://doi.org/10.2298/JSC140225079T

Tešević V, Aljančić I, Vajs V, Živković MB, Nikićević N, Urosevic I, Vujisić LV. Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies. in Journal of the Serbian Chemical Society. 2014;79(12):1537-1543.
doi:10.2298/JSC140225079T .

Tešević, Vele, Aljančić, Ivana, Vajs, Vlatka, Živković, Marijana B., Nikićević, Ninoslav, Urosevic, Ivan, Vujisić, Ljubodrag V., "Development and validation of an LC-MS/MS method with a multiple reactions monitoring mode for the quantification of vanillin and syringaldehyde in plum brandies" in Journal of the Serbian Chemical Society, 79, no. 12 (2014):1537-1543,
https://doi.org/10.2298/JSC140225079T . .

TY  - JOUR
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan M.
AU  - Todorović, Nina
AU  - Podolski-Renić, Ana
AU  - Banković, Jasna
AU  - Tanić, Nikola
AU  - Marković, Ivanka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1585
AB  - Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines
VL  - 86
SP  - 208
EP  - 217
DO  - 10.1016/j.phytochem.2012.09.003
ER  - 

@article{
author = "Jadranin, Milka and Pešić, Milica and Aljančić, Ivana and Milosavljević, Slobodan M. and Todorović, Nina and Podolski-Renić, Ana and Banković, Jasna and Tanić, Nikola and Marković, Ivanka and Vajs, Vlatka and Tešević, Vele",
year = "2013",
abstract = "Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines",
volume = "86",
pages = "208-217",
doi = "10.1016/j.phytochem.2012.09.003"
}

Jadranin, M., Pešić, M., Aljančić, I., Milosavljević, S. M., Todorović, N., Podolski-Renić, A., Banković, J., Tanić, N., Marković, I., Vajs, V.,& Tešević, V.. (2013). Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 86, 208-217.
https://doi.org/10.1016/j.phytochem.2012.09.003

Jadranin M, Pešić M, Aljančić I, Milosavljević SM, Todorović N, Podolski-Renić A, Banković J, Tanić N, Marković I, Vajs V, Tešević V. Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. in Phytochemistry. 2013;86:208-217.
doi:10.1016/j.phytochem.2012.09.003 .

Jadranin, Milka, Pešić, Milica, Aljančić, Ivana, Milosavljević, Slobodan M., Todorović, Nina, Podolski-Renić, Ana, Banković, Jasna, Tanić, Nikola, Marković, Ivanka, Vajs, Vlatka, Tešević, Vele, "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines" in Phytochemistry, 86 (2013):208-217,
https://doi.org/10.1016/j.phytochem.2012.09.003 . .

TY  - JOUR
AU  - Matić, Ivana Z.
AU  - Aljančić, Ivana
AU  - Žižak, Željko S.
AU  - Vajs, Vlatka
AU  - Jadranin, Milka
AU  - Milosavljević, Slobodan M.
AU  - Juranić, Zorica D.
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1608
AB  - Background: The aim of this research was to determine the intensity and mechanisms of the cytotoxic actions of five extracts isolated from the endemic plant species Helichrysum zivojinii Cernjavski & Soska (family Asteraceae) against specific cancer cell lines. In order to evaluate the sensitivity of normal immunocompetent cells implicated in the antitumor immune response, the cytotoxicity of extracts was also tested against healthy peripheral blood mononuclear cells (PBMC). Methods: The aerial parts of the plants were air-dried, powdered, and successively extracted with solvents of increasing polarity to obtain hexane, dichloromethane, ethyl-acetate, n-butanol and methanol extracts. The cytotoxic activities of the extracts against human cervix adenocarcinoma HeLa, human melanoma Fem-x, human myelogenous leukemia K562, human breast adenocarcinoma MDA-MB-361 cells and PBMC were evaluated by the MTT test. The mode of HeLa cell death was investigated by morphological analysis. Changes in the cell cycle of HeLa cells treated with the extracts were analyzed by flow cytometry. The apoptotic mechanisms induced by the tested extracts were determined using specific caspase inhibitors. Results: The investigated Helichrysum zivojinii extracts exerted selective dose-dependent cytotoxic actions against selected cancer cell lines and healthy immunocompetent PBMC stimulated to proliferate, while the cytotoxic actions exerted on unstimulated PBMC were less pronounced. The tested extracts exhibited considerably stronger cytotoxic activities towards HeLa, Fem-x and K562 cells in comparison to resting and stimulated PBMC. It is worth noting that the cytotoxicity of the extracts was weaker against unstimulated PBMC in comparison to stimulated PBMC. Furthermore, each of the five extracts induced apoptosis in HeLa cells, through the activation of both intrinsic and extrinsic signaling pathways. Conclusion: Extracts obtained from the endemic plant Helichrysum zivojinii may represent an important source of novel potential antitumor agents due to their pronounced and selective cytotoxic actions towards malignant cells.
PB  - Biomed Central Ltd, London
T2  - BMC Complementary and Alternative Medicine
T1  - In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii
VL  - 13
DO  - 10.1186/1472-6882-13-36
ER  - 

@article{
author = "Matić, Ivana Z. and Aljančić, Ivana and Žižak, Željko S. and Vajs, Vlatka and Jadranin, Milka and Milosavljević, Slobodan M. and Juranić, Zorica D.",
year = "2013",
abstract = "Background: The aim of this research was to determine the intensity and mechanisms of the cytotoxic actions of five extracts isolated from the endemic plant species Helichrysum zivojinii Cernjavski & Soska (family Asteraceae) against specific cancer cell lines. In order to evaluate the sensitivity of normal immunocompetent cells implicated in the antitumor immune response, the cytotoxicity of extracts was also tested against healthy peripheral blood mononuclear cells (PBMC). Methods: The aerial parts of the plants were air-dried, powdered, and successively extracted with solvents of increasing polarity to obtain hexane, dichloromethane, ethyl-acetate, n-butanol and methanol extracts. The cytotoxic activities of the extracts against human cervix adenocarcinoma HeLa, human melanoma Fem-x, human myelogenous leukemia K562, human breast adenocarcinoma MDA-MB-361 cells and PBMC were evaluated by the MTT test. The mode of HeLa cell death was investigated by morphological analysis. Changes in the cell cycle of HeLa cells treated with the extracts were analyzed by flow cytometry. The apoptotic mechanisms induced by the tested extracts were determined using specific caspase inhibitors. Results: The investigated Helichrysum zivojinii extracts exerted selective dose-dependent cytotoxic actions against selected cancer cell lines and healthy immunocompetent PBMC stimulated to proliferate, while the cytotoxic actions exerted on unstimulated PBMC were less pronounced. The tested extracts exhibited considerably stronger cytotoxic activities towards HeLa, Fem-x and K562 cells in comparison to resting and stimulated PBMC. It is worth noting that the cytotoxicity of the extracts was weaker against unstimulated PBMC in comparison to stimulated PBMC. Furthermore, each of the five extracts induced apoptosis in HeLa cells, through the activation of both intrinsic and extrinsic signaling pathways. Conclusion: Extracts obtained from the endemic plant Helichrysum zivojinii may represent an important source of novel potential antitumor agents due to their pronounced and selective cytotoxic actions towards malignant cells.",
publisher = "Biomed Central Ltd, London",
journal = "BMC Complementary and Alternative Medicine",
title = "In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii",
volume = "13",
doi = "10.1186/1472-6882-13-36"
}

Matić, I. Z., Aljančić, I., Žižak, Ž. S., Vajs, V., Jadranin, M., Milosavljević, S. M.,& Juranić, Z. D.. (2013). In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii. in BMC Complementary and Alternative Medicine
Biomed Central Ltd, London., 13.
https://doi.org/10.1186/1472-6882-13-36

Matić IZ, Aljančić I, Žižak ŽS, Vajs V, Jadranin M, Milosavljević SM, Juranić ZD. In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii. in BMC Complementary and Alternative Medicine. 2013;13.
doi:10.1186/1472-6882-13-36 .

Matić, Ivana Z., Aljančić, Ivana, Žižak, Željko S., Vajs, Vlatka, Jadranin, Milka, Milosavljević, Slobodan M., Juranić, Zorica D., "In vitro antitumor actions of extracts from endemic plant Helichrysum zivojinii" in BMC Complementary and Alternative Medicine, 13 (2013),
https://doi.org/10.1186/1472-6882-13-36 . .

TY  - DATA
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan M.
AU  - Todorović, Nina
AU  - Podolski-Renić, Ana
AU  - Banković, Jasna
AU  - Tanić, Nikola
AU  - Marković, Ivanka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2902
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Supplementary data for the article:   Jadranin, M.; Pešić, M.; Aljančić, I. S.; Milosavljević, S. M.; Todorović, N. M.; Podolski-Renić, A.; Banković, J.; Tanić, N.; Marković, I.; Vajs, V. E.; et al. Jatrophane Diterpenoids from the Latex of Euphorbia Dendroides and Their Anti-P-Glycoprotein Activity in Human Multi-Drug Resistant Cancer Cell Lines. Phytochemistry 2013, 86, 208–217. https://doi.org/10.1016/j.phytochem.2012.09.003
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2902
ER  - 

@misc{
author = "Jadranin, Milka and Pešić, Milica and Aljančić, Ivana and Milosavljević, Slobodan M. and Todorović, Nina and Podolski-Renić, Ana and Banković, Jasna and Tanić, Nikola and Marković, Ivanka and Vajs, Vlatka and Tešević, Vele",
year = "2013",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Supplementary data for the article:   Jadranin, M.; Pešić, M.; Aljančić, I. S.; Milosavljević, S. M.; Todorović, N. M.; Podolski-Renić, A.; Banković, J.; Tanić, N.; Marković, I.; Vajs, V. E.; et al. Jatrophane Diterpenoids from the Latex of Euphorbia Dendroides and Their Anti-P-Glycoprotein Activity in Human Multi-Drug Resistant Cancer Cell Lines. Phytochemistry 2013, 86, 208–217. https://doi.org/10.1016/j.phytochem.2012.09.003",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2902"
}

Jadranin, M., Pešić, M., Aljančić, I., Milosavljević, S. M., Todorović, N., Podolski-Renić, A., Banković, J., Tanić, N., Marković, I., Vajs, V.,& Tešević, V.. (2013). Supplementary data for the article:   Jadranin, M.; Pešić, M.; Aljančić, I. S.; Milosavljević, S. M.; Todorović, N. M.; Podolski-Renić, A.; Banković, J.; Tanić, N.; Marković, I.; Vajs, V. E.; et al. Jatrophane Diterpenoids from the Latex of Euphorbia Dendroides and Their Anti-P-Glycoprotein Activity in Human Multi-Drug Resistant Cancer Cell Lines. Phytochemistry 2013, 86, 208–217. https://doi.org/10.1016/j.phytochem.2012.09.003. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford..
https://hdl.handle.net/21.15107/rcub_cherry_2902

Jadranin M, Pešić M, Aljančić I, Milosavljević SM, Todorović N, Podolski-Renić A, Banković J, Tanić N, Marković I, Vajs V, Tešević V. Supplementary data for the article:   Jadranin, M.; Pešić, M.; Aljančić, I. S.; Milosavljević, S. M.; Todorović, N. M.; Podolski-Renić, A.; Banković, J.; Tanić, N.; Marković, I.; Vajs, V. E.; et al. Jatrophane Diterpenoids from the Latex of Euphorbia Dendroides and Their Anti-P-Glycoprotein Activity in Human Multi-Drug Resistant Cancer Cell Lines. Phytochemistry 2013, 86, 208–217. https://doi.org/10.1016/j.phytochem.2012.09.003. in Phytochemistry. 2013;.
https://hdl.handle.net/21.15107/rcub_cherry_2902 .

Jadranin, Milka, Pešić, Milica, Aljančić, Ivana, Milosavljević, Slobodan M., Todorović, Nina, Podolski-Renić, Ana, Banković, Jasna, Tanić, Nikola, Marković, Ivanka, Vajs, Vlatka, Tešević, Vele, "Supplementary data for the article:   Jadranin, M.; Pešić, M.; Aljančić, I. S.; Milosavljević, S. M.; Todorović, N. M.; Podolski-Renić, A.; Banković, J.; Tanić, N.; Marković, I.; Vajs, V. E.; et al. Jatrophane Diterpenoids from the Latex of Euphorbia Dendroides and Their Anti-P-Glycoprotein Activity in Human Multi-Drug Resistant Cancer Cell Lines. Phytochemistry 2013, 86, 208–217. https://doi.org/10.1016/j.phytochem.2012.09.003" in Phytochemistry (2013),
https://hdl.handle.net/21.15107/rcub_cherry_2902 .

TY  - JOUR
AU  - Matić, Ivana Z.
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Jadranin, Milka
AU  - Gligorijević, Nevenka
AU  - Milosavljević, Slobodan M.
AU  - Juranić, Zorica D.
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1435
AB  - Helichrysum zivojinii Cernjavski & Soska is an endemic plant species that grows in the National Park Galicica in Macedonia. Five extracts were isolated as fractions from the aerial parts of the plant: a n-hexane extract (1), a dichloromethane extract (2), an ethyl-acetate extract (3), a n-butanol extract (4) and a methanol extract (5). A dose-dependent cytotoxic activity of the extracts on MDA-MB-231 and EA.hy926 cells was observed. Extracts exhibited more pronounced cytotoxic actions on MDA-MB-231 cells than on EA.hy926 cells. The n-hexane extract (1), at a non-toxic concentration, exhibited an inhibitory effect on the migration as well the invasiveness of MDA-MB-231 cells. The dichloromethane extract (2), at a non-toxic concentration, demonstrated inhibition of MDA-MB-231 cells invasion. Each of the five extracts applied at non-toxic concentrations inhibited migration of EA.hy926 cells. The prominent inhibitory effect of the n-hexane extract on EA.hy926 cells migration was associated with a notable anti-angiogenic action of this extract. The other four tested extracts demonstrated mild anti-angiogenic activity. Our data highlight the prominent anticancer potential of n-hexane (1) and dichloromethane (2) extracts, which could be attributed to their very pronounced and selective cytotoxic activities as well as their anti-invasive and anti-angiogenic properties.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis
VL  - 8
IS  - 9
SP  - 1291
EP  - 1296
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1435
ER  - 

@article{
author = "Matić, Ivana Z. and Aljančić, Ivana and Vajs, Vlatka and Jadranin, Milka and Gligorijević, Nevenka and Milosavljević, Slobodan M. and Juranić, Zorica D.",
year = "2013",
abstract = "Helichrysum zivojinii Cernjavski & Soska is an endemic plant species that grows in the National Park Galicica in Macedonia. Five extracts were isolated as fractions from the aerial parts of the plant: a n-hexane extract (1), a dichloromethane extract (2), an ethyl-acetate extract (3), a n-butanol extract (4) and a methanol extract (5). A dose-dependent cytotoxic activity of the extracts on MDA-MB-231 and EA.hy926 cells was observed. Extracts exhibited more pronounced cytotoxic actions on MDA-MB-231 cells than on EA.hy926 cells. The n-hexane extract (1), at a non-toxic concentration, exhibited an inhibitory effect on the migration as well the invasiveness of MDA-MB-231 cells. The dichloromethane extract (2), at a non-toxic concentration, demonstrated inhibition of MDA-MB-231 cells invasion. Each of the five extracts applied at non-toxic concentrations inhibited migration of EA.hy926 cells. The prominent inhibitory effect of the n-hexane extract on EA.hy926 cells migration was associated with a notable anti-angiogenic action of this extract. The other four tested extracts demonstrated mild anti-angiogenic activity. Our data highlight the prominent anticancer potential of n-hexane (1) and dichloromethane (2) extracts, which could be attributed to their very pronounced and selective cytotoxic activities as well as their anti-invasive and anti-angiogenic properties.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis",
volume = "8",
number = "9",
pages = "1291-1296",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1435"
}

Matić, I. Z., Aljančić, I., Vajs, V., Jadranin, M., Gligorijević, N., Milosavljević, S. M.,& Juranić, Z. D.. (2013). Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis. in Natural Product Communications
Natural Products Inc, Westerville., 8(9), 1291-1296.
https://hdl.handle.net/21.15107/rcub_cherry_1435

Matić IZ, Aljančić I, Vajs V, Jadranin M, Gligorijević N, Milosavljević SM, Juranić ZD. Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis. in Natural Product Communications. 2013;8(9):1291-1296.
https://hdl.handle.net/21.15107/rcub_cherry_1435 .

Matić, Ivana Z., Aljančić, Ivana, Vajs, Vlatka, Jadranin, Milka, Gligorijević, Nevenka, Milosavljević, Slobodan M., Juranić, Zorica D., "Cancer-Suppressive Potential of Extracts of Endemic Plant Helichrysum zivojinii: Effects on Cell Migration, Invasion and Angiogenesis" in Natural Product Communications, 8, no. 9 (2013):1291-1296,
https://hdl.handle.net/21.15107/rcub_cherry_1435 .

TY  - JOUR
AU  - Podolski-Renić, Ana
AU  - Jadranin, Milka
AU  - Stanković, Tijana
AU  - Banković, Jasna
AU  - Stojković, Sonja
AU  - Chiourea, Maria
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Ruzdijic, Sabera
AU  - Gagos, Sarantis
AU  - Tanić, Nikola
AU  - Pešić, Milica
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1393
AB  - Multi-drug resistance (MDR) is a major obstacle to successful cancer treatment. Therefore, in vitro models are necessary for the investigation of the phenotypic changes provoked by cytotoxic agents and more importantly for preclinical testing of new anticancer drugs. We analyzed chromosomal, numerical, and structural changes after development of MDR, alterations in p53 and PTEN, single nucleotide polymorphisms (SNPs) in the mdr1 gene and corresponding protein expression of P-glycoprotein (P-gp) in three human MDR cancer cell lines: non-small cell lung carcinoma NCI-H460/R, colorectal carcinoma DLD1-TxR, and glioma U87-TxR. In addition, we explored how these molecular and phenotypic alterations influence the anticancer effect of new drugs. Cytogenetic analysis showed polyploidy reduction after development of MDR in U87-TxR. Losses of 6q in all resistant cancer cell lines and inactivation of p53 in U87-TxR and PTEN in DLD1-TxR were also revealed. Overexpression of P-gp was observed in all MDR cancer cell lines. We evaluated the anticancer activities and MDR reversal potential of Akt inhibitor GSK690693, Ras inhibitor Tipifarnib, and two P-gp inhibitors (jatrophane diterpenoids). Their effects vary due to the cell-type differences, existence of MDR phenotype, presence of mdr1 SNP, and tumor suppressors' alterations. Tipifarnib and jatrophane diterpenoids significantly sensitized MDR cancer cells to paclitaxel. In conclusion, investigated MDR cancer cells obtained new molecular and cytogenetic characteristics that may serve as potential clinical prognostic markers. In addition, these MDR cancer cell lines present a valuable model for preclinical evaluation of new anticancer agents.
PB  - Springer, New York
T2  - Cancer Chemotherapy and Pharmacology
T1  - Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing
VL  - 72
IS  - 3
SP  - 683
EP  - 697
DO  - 10.1007/s00280-013-2247-1
ER  - 

@article{
author = "Podolski-Renić, Ana and Jadranin, Milka and Stanković, Tijana and Banković, Jasna and Stojković, Sonja and Chiourea, Maria and Aljančić, Ivana and Vajs, Vlatka and Tešević, Vele and Ruzdijic, Sabera and Gagos, Sarantis and Tanić, Nikola and Pešić, Milica",
year = "2013",
abstract = "Multi-drug resistance (MDR) is a major obstacle to successful cancer treatment. Therefore, in vitro models are necessary for the investigation of the phenotypic changes provoked by cytotoxic agents and more importantly for preclinical testing of new anticancer drugs. We analyzed chromosomal, numerical, and structural changes after development of MDR, alterations in p53 and PTEN, single nucleotide polymorphisms (SNPs) in the mdr1 gene and corresponding protein expression of P-glycoprotein (P-gp) in three human MDR cancer cell lines: non-small cell lung carcinoma NCI-H460/R, colorectal carcinoma DLD1-TxR, and glioma U87-TxR. In addition, we explored how these molecular and phenotypic alterations influence the anticancer effect of new drugs. Cytogenetic analysis showed polyploidy reduction after development of MDR in U87-TxR. Losses of 6q in all resistant cancer cell lines and inactivation of p53 in U87-TxR and PTEN in DLD1-TxR were also revealed. Overexpression of P-gp was observed in all MDR cancer cell lines. We evaluated the anticancer activities and MDR reversal potential of Akt inhibitor GSK690693, Ras inhibitor Tipifarnib, and two P-gp inhibitors (jatrophane diterpenoids). Their effects vary due to the cell-type differences, existence of MDR phenotype, presence of mdr1 SNP, and tumor suppressors' alterations. Tipifarnib and jatrophane diterpenoids significantly sensitized MDR cancer cells to paclitaxel. In conclusion, investigated MDR cancer cells obtained new molecular and cytogenetic characteristics that may serve as potential clinical prognostic markers. In addition, these MDR cancer cell lines present a valuable model for preclinical evaluation of new anticancer agents.",
publisher = "Springer, New York",
journal = "Cancer Chemotherapy and Pharmacology",
title = "Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing",
volume = "72",
number = "3",
pages = "683-697",
doi = "10.1007/s00280-013-2247-1"
}

Podolski-Renić, A., Jadranin, M., Stanković, T., Banković, J., Stojković, S., Chiourea, M., Aljančić, I., Vajs, V., Tešević, V., Ruzdijic, S., Gagos, S., Tanić, N.,& Pešić, M.. (2013). Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing. in Cancer Chemotherapy and Pharmacology
Springer, New York., 72(3), 683-697.
https://doi.org/10.1007/s00280-013-2247-1

Podolski-Renić A, Jadranin M, Stanković T, Banković J, Stojković S, Chiourea M, Aljančić I, Vajs V, Tešević V, Ruzdijic S, Gagos S, Tanić N, Pešić M. Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing. in Cancer Chemotherapy and Pharmacology. 2013;72(3):683-697.
doi:10.1007/s00280-013-2247-1 .

Podolski-Renić, Ana, Jadranin, Milka, Stanković, Tijana, Banković, Jasna, Stojković, Sonja, Chiourea, Maria, Aljančić, Ivana, Vajs, Vlatka, Tešević, Vele, Ruzdijic, Sabera, Gagos, Sarantis, Tanić, Nikola, Pešić, Milica, "Molecular and cytogenetic changes in multi-drug resistant cancer cells and their influence on new compounds testing" in Cancer Chemotherapy and Pharmacology, 72, no. 3 (2013):683-697,
https://doi.org/10.1007/s00280-013-2247-1 . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Pešić, Milica
AU  - Milosavljević, Slobodan M.
AU  - Todorović, Nina
AU  - Jadranin, Milka
AU  - Miosavljevic, Goran
AU  - Povrenovic, Dragan
AU  - Banković, Jasna
AU  - Tanić, Nikola
AU  - Marković, Ivanka
AU  - Ruzdijic, Sabera
AU  - Vajs, Vlatka
AU  - Tešević, Vele
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1178
AB  - From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
PB  - Amer Chemical Soc, Washington
T2  - Journal of Natural Products
T1  - Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides
VL  - 74
IS  - 7
SP  - 1613
EP  - 1620
DO  - 10.1021/np200241c
ER  - 

@article{
author = "Aljančić, Ivana and Pešić, Milica and Milosavljević, Slobodan M. and Todorović, Nina and Jadranin, Milka and Miosavljevic, Goran and Povrenovic, Dragan and Banković, Jasna and Tanić, Nikola and Marković, Ivanka and Ruzdijic, Sabera and Vajs, Vlatka and Tešević, Vele",
year = "2011",
abstract = "From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Natural Products",
title = "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides",
volume = "74",
number = "7",
pages = "1613-1620",
doi = "10.1021/np200241c"
}

Aljančić, I., Pešić, M., Milosavljević, S. M., Todorović, N., Jadranin, M., Miosavljevic, G., Povrenovic, D., Banković, J., Tanić, N., Marković, I., Ruzdijic, S., Vajs, V.,& Tešević, V.. (2011). Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products
Amer Chemical Soc, Washington., 74(7), 1613-1620.
https://doi.org/10.1021/np200241c

Aljančić I, Pešić M, Milosavljević SM, Todorović N, Jadranin M, Miosavljevic G, Povrenovic D, Banković J, Tanić N, Marković I, Ruzdijic S, Vajs V, Tešević V. Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides. in Journal of Natural Products. 2011;74(7):1613-1620.
doi:10.1021/np200241c .

Aljančić, Ivana, Pešić, Milica, Milosavljević, Slobodan M., Todorović, Nina, Jadranin, Milka, Miosavljevic, Goran, Povrenovic, Dragan, Banković, Jasna, Tanić, Nikola, Marković, Ivanka, Ruzdijic, Sabera, Vajs, Vlatka, Tešević, Vele, "Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides" in Journal of Natural Products, 74, no. 7 (2011):1613-1620,
https://doi.org/10.1021/np200241c . .

TY  - JOUR
AU  - Pešić, Milica
AU  - Banković, Jasna
AU  - Aljančić, Ivana
AU  - Todorović, Nina
AU  - Jadranin, Milka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Vučković, Ivan M.
AU  - Momčilović, Miljana
AU  - Marković, Ivanka
AU  - Tanić, Nikola
AU  - Ruzdijic, Sabera
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1233
AB  - Jatrophane diterpenes were shown to be inhibitors of P-glycoprotein (P-gp). There are also evidences on their microtubule-interacting activity in cancer cells. We evaluated new anti-cancer characteristics of two jatrophane type compounds from Euphorbia dendroides. For that purpose, the model system of sensitive non-small cell lung cancer cell line (NCI-H460) and its resistant counterpart (NCI-H460/R) was used. Although both jatrophanes showed inhibitory effect on cancer cell growth, they were non-toxic for peripheral blood mononuclear cells (PBMC). We examined their effects in combination with paclitaxel (PTX), a well-known mitotic spindle interacting chemotherapeutic. Jatrophanes overcome PTX resistance in concentration-dependent manner in MDR cancer cell line (NCI-H460/R). We observed that this synergistic effect is not caused merely by P-gp inhibition. In combination with PTX, jatrophanes induce cell killing and change cell cycle distribution leading to G2/M arrest. Furthermore, they exert an anti-angiogenic effect by decreasing the vascular endothelial growth factor (VEGF) secretion. The reduction of the level of mdr1 mRNA expression in sensitive cells, suggests that these compounds could not contribute to the development of resistance. In conclusion, present study provides a rational basis for the new cancer treatment approach with jatrophanes that are non-toxic to normal cells and have new favorable anti-cancer characteristics. (C) 2011 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides
VL  - 49
IS  - 12
SP  - 3165
EP  - 3173
DO  - 10.1016/j.fct.2011.09.035
ER  - 

@article{
author = "Pešić, Milica and Banković, Jasna and Aljančić, Ivana and Todorović, Nina and Jadranin, Milka and Vajs, Vlatka and Tešević, Vele and Vučković, Ivan M. and Momčilović, Miljana and Marković, Ivanka and Tanić, Nikola and Ruzdijic, Sabera",
year = "2011",
abstract = "Jatrophane diterpenes were shown to be inhibitors of P-glycoprotein (P-gp). There are also evidences on their microtubule-interacting activity in cancer cells. We evaluated new anti-cancer characteristics of two jatrophane type compounds from Euphorbia dendroides. For that purpose, the model system of sensitive non-small cell lung cancer cell line (NCI-H460) and its resistant counterpart (NCI-H460/R) was used. Although both jatrophanes showed inhibitory effect on cancer cell growth, they were non-toxic for peripheral blood mononuclear cells (PBMC). We examined their effects in combination with paclitaxel (PTX), a well-known mitotic spindle interacting chemotherapeutic. Jatrophanes overcome PTX resistance in concentration-dependent manner in MDR cancer cell line (NCI-H460/R). We observed that this synergistic effect is not caused merely by P-gp inhibition. In combination with PTX, jatrophanes induce cell killing and change cell cycle distribution leading to G2/M arrest. Furthermore, they exert an anti-angiogenic effect by decreasing the vascular endothelial growth factor (VEGF) secretion. The reduction of the level of mdr1 mRNA expression in sensitive cells, suggests that these compounds could not contribute to the development of resistance. In conclusion, present study provides a rational basis for the new cancer treatment approach with jatrophanes that are non-toxic to normal cells and have new favorable anti-cancer characteristics. (C) 2011 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides",
volume = "49",
number = "12",
pages = "3165-3173",
doi = "10.1016/j.fct.2011.09.035"
}

Pešić, M., Banković, J., Aljančić, I., Todorović, N., Jadranin, M., Vajs, V., Tešević, V., Vučković, I. M., Momčilović, M., Marković, I., Tanić, N.,& Ruzdijic, S.. (2011). New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 49(12), 3165-3173.
https://doi.org/10.1016/j.fct.2011.09.035

Pešić M, Banković J, Aljančić I, Todorović N, Jadranin M, Vajs V, Tešević V, Vučković IM, Momčilović M, Marković I, Tanić N, Ruzdijic S. New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides. in Food and Chemical Toxicology. 2011;49(12):3165-3173.
doi:10.1016/j.fct.2011.09.035 .

Pešić, Milica, Banković, Jasna, Aljančić, Ivana, Todorović, Nina, Jadranin, Milka, Vajs, Vlatka, Tešević, Vele, Vučković, Ivan M., Momčilović, Miljana, Marković, Ivanka, Tanić, Nikola, Ruzdijic, Sabera, "New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides" in Food and Chemical Toxicology, 49, no. 12 (2011):3165-3173,
https://doi.org/10.1016/j.fct.2011.09.035 . .

TY  - CONF
AU  - Matic, I.
AU  - Juranić, Z.
AU  - Žižak, Željko S.
AU  - Vajs, Vlatka
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan M.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1164
PB  - Pergamon-Elsevier Science Ltd, Oxford
C3  - European Journal of Cancer Supplements / EJC Supplements
T1  - Extracts from endemic plant Helichrysum zivojini suppress survival of malignant cells
VL  - 8
IS  - 5
SP  - 150
EP  - 150
DO  - 10.1016/S1359-6349(10)71390-2
ER  - 

@conference{
author = "Matic, I. and Juranić, Z. and Žižak, Željko S. and Vajs, Vlatka and Aljančić, Ivana and Milosavljević, Slobodan M.",
year = "2010",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "European Journal of Cancer Supplements / EJC Supplements",
title = "Extracts from endemic plant Helichrysum zivojini suppress survival of malignant cells",
volume = "8",
number = "5",
pages = "150-150",
doi = "10.1016/S1359-6349(10)71390-2"
}

Matic, I., Juranić, Z., Žižak, Ž. S., Vajs, V., Aljančić, I.,& Milosavljević, S. M.. (2010). Extracts from endemic plant Helichrysum zivojini suppress survival of malignant cells. in European Journal of Cancer Supplements / EJC Supplements
Pergamon-Elsevier Science Ltd, Oxford., 8(5), 150-150.
https://doi.org/10.1016/S1359-6349(10)71390-2

Matic I, Juranić Z, Žižak ŽS, Vajs V, Aljančić I, Milosavljević SM. Extracts from endemic plant Helichrysum zivojini suppress survival of malignant cells. in European Journal of Cancer Supplements / EJC Supplements. 2010;8(5):150-150.
doi:10.1016/S1359-6349(10)71390-2 .

Matic, I., Juranić, Z., Žižak, Željko S., Vajs, Vlatka, Aljančić, Ivana, Milosavljević, Slobodan M., "Extracts from endemic plant Helichrysum zivojini suppress survival of malignant cells" in European Journal of Cancer Supplements / EJC Supplements, 8, no. 5 (2010):150-150,
https://doi.org/10.1016/S1359-6349(10)71390-2 . .

TY  - JOUR
AU  - Tadić, Vanja M.
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Đoković, Dejan
AU  - Đorđević, Iris
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1110
AB  - The essential oil from aerial parts of Tanacetum larvatum (Gris.) Kanitz, an endemic perennial herb collected at three various natural habitats in Montenegro (Planinica [Sample a], Visitor [Sample b] and Sinjajevina [Sample c]), were analyzed using GC and GC/MS. Sixty-four components were identified, representing 83.1%, 96.6% and 89.4% of the total oils content in the Samples a, b and c, respectively. The major constituent in Samples a and b, was oxygenated monoterpene, trans-sabinyl acetate (38.1% and 55.8% respectively). Monoterpene hydrocarbons, beta-pinene (13.5%) and santolinatriene (30.6%), were found to be the dominant components in Sample c. The toxic trans-sabinyl acetate was present only in traces in this sample. trans-Chrysanthenyl acetate, as one of major components in feverfew essential oil, has not been previously identified in the investigated essential oils.
PB  - Allured Publ Corp, Carol Stream
T2  - Journal of Essential Oil Research
T1  - Intraspecific Variation of Tanacetum larvatum Essential Oil
VL  - 22
IS  - 5
SP  - 394
EP  - 398
DO  - 10.1080/10412905.2010.9700355
ER  - 

@article{
author = "Tadić, Vanja M. and Aljančić, Ivana and Vajs, Vlatka and Milosavljević, Slobodan M. and Đoković, Dejan and Đorđević, Iris",
year = "2010",
abstract = "The essential oil from aerial parts of Tanacetum larvatum (Gris.) Kanitz, an endemic perennial herb collected at three various natural habitats in Montenegro (Planinica [Sample a], Visitor [Sample b] and Sinjajevina [Sample c]), were analyzed using GC and GC/MS. Sixty-four components were identified, representing 83.1%, 96.6% and 89.4% of the total oils content in the Samples a, b and c, respectively. The major constituent in Samples a and b, was oxygenated monoterpene, trans-sabinyl acetate (38.1% and 55.8% respectively). Monoterpene hydrocarbons, beta-pinene (13.5%) and santolinatriene (30.6%), were found to be the dominant components in Sample c. The toxic trans-sabinyl acetate was present only in traces in this sample. trans-Chrysanthenyl acetate, as one of major components in feverfew essential oil, has not been previously identified in the investigated essential oils.",
publisher = "Allured Publ Corp, Carol Stream",
journal = "Journal of Essential Oil Research",
title = "Intraspecific Variation of Tanacetum larvatum Essential Oil",
volume = "22",
number = "5",
pages = "394-398",
doi = "10.1080/10412905.2010.9700355"
}

Tadić, V. M., Aljančić, I., Vajs, V., Milosavljević, S. M., Đoković, D.,& Đorđević, I.. (2010). Intraspecific Variation of Tanacetum larvatum Essential Oil. in Journal of Essential Oil Research
Allured Publ Corp, Carol Stream., 22(5), 394-398.
https://doi.org/10.1080/10412905.2010.9700355

Tadić VM, Aljančić I, Vajs V, Milosavljević SM, Đoković D, Đorđević I. Intraspecific Variation of Tanacetum larvatum Essential Oil. in Journal of Essential Oil Research. 2010;22(5):394-398.
doi:10.1080/10412905.2010.9700355 .

Tadić, Vanja M., Aljančić, Ivana, Vajs, Vlatka, Milosavljević, Slobodan M., Đoković, Dejan, Đorđević, Iris, "Intraspecific Variation of Tanacetum larvatum Essential Oil" in Journal of Essential Oil Research, 22, no. 5 (2010):394-398,
https://doi.org/10.1080/10412905.2010.9700355 . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Stanković, Miroslava
AU  - Tešević, Vele
AU  - Vujisić, Ljubodrag V.
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1079
AB  - This study was conducted to elucidate the in vitro protective effect of five flavonoids [apigenin (1), apigenin-7-O-glucoside (2), centaureidin (3), jaceidin (4) and quercetin (5)] against chromosomal damage in mitogen-induced human lymphocytes. Using the Cytochalasin-B blocked micronucleus (CBMN) assay, in which the biomarker of chromosome breakage and/or chromosome loss is the elevated frequency of micronucleus (MN) in binucleated (BN) cells, the presence of flavonoid 2 in minimal concentration (3 mu g/mL) gave a 35.5% decrease M the frequency of MN when compared with control human lymphocytes. The same concentration of flavonoids 1, 3 and 4, reduced the MN frequency by 24.4%, 28.0% and 28.0%, respectively. Higher concentrations (6 mu g/mL and 10 mu g/mL) seemed less effective. Flavonoid 5 (3 mu g/mL.) induced a slight decrease in MN frequency (5%), while higher doses (6 mu g/mL and 10 mu g/mL) provoked an increase of DNA damage. The comparable values for the cytokinesis-block proliferation index (CBPI) of the tested flavonoids and positive control suggested an inhibitory effect on lymphocyte proliferation. In the DPPH scavenging assay, flavonoids 1-4 demonstrated modest activity, in a dose-dependent manner, compared with the synthetic antioxidants BHT and Trolox, while 5 exhibited comparably high antioxidative activity.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species
VL  - 5
IS  - 5
SP  - 729
EP  - 732
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1079
ER  - 

@article{
author = "Aljančić, Ivana and Stanković, Miroslava and Tešević, Vele and Vujisić, Ljubodrag V. and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2010",
abstract = "This study was conducted to elucidate the in vitro protective effect of five flavonoids [apigenin (1), apigenin-7-O-glucoside (2), centaureidin (3), jaceidin (4) and quercetin (5)] against chromosomal damage in mitogen-induced human lymphocytes. Using the Cytochalasin-B blocked micronucleus (CBMN) assay, in which the biomarker of chromosome breakage and/or chromosome loss is the elevated frequency of micronucleus (MN) in binucleated (BN) cells, the presence of flavonoid 2 in minimal concentration (3 mu g/mL) gave a 35.5% decrease M the frequency of MN when compared with control human lymphocytes. The same concentration of flavonoids 1, 3 and 4, reduced the MN frequency by 24.4%, 28.0% and 28.0%, respectively. Higher concentrations (6 mu g/mL and 10 mu g/mL) seemed less effective. Flavonoid 5 (3 mu g/mL.) induced a slight decrease in MN frequency (5%), while higher doses (6 mu g/mL and 10 mu g/mL) provoked an increase of DNA damage. The comparable values for the cytokinesis-block proliferation index (CBPI) of the tested flavonoids and positive control suggested an inhibitory effect on lymphocyte proliferation. In the DPPH scavenging assay, flavonoids 1-4 demonstrated modest activity, in a dose-dependent manner, compared with the synthetic antioxidants BHT and Trolox, while 5 exhibited comparably high antioxidative activity.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species",
volume = "5",
number = "5",
pages = "729-732",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1079"
}

Aljančić, I., Stanković, M., Tešević, V., Vujisić, L. V., Vajs, V.,& Milosavljević, S. M.. (2010). Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species. in Natural Product Communications
Natural Products Inc, Westerville., 5(5), 729-732.
https://hdl.handle.net/21.15107/rcub_cherry_1079

Aljančić I, Stanković M, Tešević V, Vujisić LV, Vajs V, Milosavljević SM. Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species. in Natural Product Communications. 2010;5(5):729-732.
https://hdl.handle.net/21.15107/rcub_cherry_1079 .

Aljančić, Ivana, Stanković, Miroslava, Tešević, Vele, Vujisić, Ljubodrag V., Vajs, Vlatka, Milosavljević, Slobodan M., "Protective Effect on Human Lymphocytes of Some Flavonoids Isolated from Two Achillea Species" in Natural Product Communications, 5, no. 5 (2010):729-732,
https://hdl.handle.net/21.15107/rcub_cherry_1079 .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Todorović, Nevena M.
AU  - Menkovic, N. R.
AU  - Godjevac, Dejan
AU  - Tadić, Vanja M.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1138
PB  - Springer, New York
T2  - Chemistry of Natural Compounds
T1  - Comparative Analysis of Parthenolide Content in Tanacetum Larvatum, An Endemic Species of Montenegro, Collected from  Three Different Locations
VL  - 46
IS  - 4
SP  - 658
EP  - 660
DO  - 10.1007/s10600-010-9706-2
ER  - 

@article{
author = "Aljančić, Ivana and Vajs, Vlatka and Milosavljević, Slobodan M. and Todorović, Nevena M. and Menkovic, N. R. and Godjevac, Dejan and Tadić, Vanja M.",
year = "2010",
publisher = "Springer, New York",
journal = "Chemistry of Natural Compounds",
title = "Comparative Analysis of Parthenolide Content in Tanacetum Larvatum, An Endemic Species of Montenegro, Collected from  Three Different Locations",
volume = "46",
number = "4",
pages = "658-660",
doi = "10.1007/s10600-010-9706-2"
}

Aljančić, I., Vajs, V., Milosavljević, S. M., Todorović, N. M., Menkovic, N. R., Godjevac, D.,& Tadić, V. M.. (2010). Comparative Analysis of Parthenolide Content in Tanacetum Larvatum, An Endemic Species of Montenegro, Collected from  Three Different Locations. in Chemistry of Natural Compounds
Springer, New York., 46(4), 658-660.
https://doi.org/10.1007/s10600-010-9706-2

Aljančić I, Vajs V, Milosavljević SM, Todorović NM, Menkovic NR, Godjevac D, Tadić VM. Comparative Analysis of Parthenolide Content in Tanacetum Larvatum, An Endemic Species of Montenegro, Collected from  Three Different Locations. in Chemistry of Natural Compounds. 2010;46(4):658-660.
doi:10.1007/s10600-010-9706-2 .

Aljančić, Ivana, Vajs, Vlatka, Milosavljević, Slobodan M., Todorović, Nevena M., Menkovic, N. R., Godjevac, Dejan, Tadić, Vanja M., "Comparative Analysis of Parthenolide Content in Tanacetum Larvatum, An Endemic Species of Montenegro, Collected from  Three Different Locations" in Chemistry of Natural Compounds, 46, no. 4 (2010):658-660,
https://doi.org/10.1007/s10600-010-9706-2 . .

TY  - JOUR
AU  - Arfan, Mohammad
AU  - Raziq, Naila
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan M.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/614
AB  - 4-Chlorobenzoic acid (1), quercitrin (2), astilbin (3), along with beta-sitosterol, gamma-sitosterol, friedelin and beta-amyrin were isolated from the aerial parts of Hypericum monogynum. Whereas compound 1 was isolated for the first time from natural sources, flavanonol 3 was not found before in these species.
AB  - 4-Hlorobenzoeva kiselina (1), kvercitrin (2), astilbin (3), kao i β-sitosterol, γ- sitosterol, fridelin i β-amirin izolovani su iz nadzemnih delova biljne vrste Hypericum monogynum. Po prvi put jedinjenje 1 je izolovano iz prirodnih izvora, dok flavanonol 3 do sada nije izolovan iz ove biljne vrste.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Secondary metabolites of Hypericum monogynum from Pakistan
T1  - Sekundarni metaboliti biljne vrste Hypericum monogynum iz Pakistana
VL  - 74
IS  - 2
SP  - 129
EP  - 132
DO  - 10.2298/JSC0902129A
ER  - 

@article{
author = "Arfan, Mohammad and Raziq, Naila and Aljančić, Ivana and Milosavljević, Slobodan M.",
year = "2009",
abstract = "4-Chlorobenzoic acid (1), quercitrin (2), astilbin (3), along with beta-sitosterol, gamma-sitosterol, friedelin and beta-amyrin were isolated from the aerial parts of Hypericum monogynum. Whereas compound 1 was isolated for the first time from natural sources, flavanonol 3 was not found before in these species., 4-Hlorobenzoeva kiselina (1), kvercitrin (2), astilbin (3), kao i β-sitosterol, γ- sitosterol, fridelin i β-amirin izolovani su iz nadzemnih delova biljne vrste Hypericum monogynum. Po prvi put jedinjenje 1 je izolovano iz prirodnih izvora, dok flavanonol 3 do sada nije izolovan iz ove biljne vrste.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Secondary metabolites of Hypericum monogynum from Pakistan, Sekundarni metaboliti biljne vrste Hypericum monogynum iz Pakistana",
volume = "74",
number = "2",
pages = "129-132",
doi = "10.2298/JSC0902129A"
}

Arfan, M., Raziq, N., Aljančić, I.,& Milosavljević, S. M.. (2009). Secondary metabolites of Hypericum monogynum from Pakistan. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 74(2), 129-132.
https://doi.org/10.2298/JSC0902129A

Arfan M, Raziq N, Aljančić I, Milosavljević SM. Secondary metabolites of Hypericum monogynum from Pakistan. in Journal of the Serbian Chemical Society. 2009;74(2):129-132.
doi:10.2298/JSC0902129A .

Arfan, Mohammad, Raziq, Naila, Aljančić, Ivana, Milosavljević, Slobodan M., "Secondary metabolites of Hypericum monogynum from Pakistan" in Journal of the Serbian Chemical Society, 74, no. 2 (2009):129-132,
https://doi.org/10.2298/JSC0902129A . .

TY  - JOUR
AU  - Jankovic, Teodora
AU  - Krstic-Milosevic, Dijana
AU  - Aljančić, Ivana
AU  - Šavikin, Katarina
AU  - Menkovic, Nebojsa
AU  - Radanović, Dragoja
AU  - Milosavljević, Slobodan M.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/615
AB  - Xanthone-O-glycosides with 1,3,7,8-oxidation pattern and flavone isoorientin-3'-O-glucoside were isolated from the aerial parts of Gentiana utriculosa. Xanthone-C-glucoside lancerin was detected in Gentiana species for the first time. The distribution of these compounds within the section Calathianae is discussed.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Phytochemical re-investigation of Gentiana utriculosa
VL  - 23
IS  - 5
SP  - 466
EP  - 469
DO  - 10.1080/14786410802079477
ER  - 

@article{
author = "Jankovic, Teodora and Krstic-Milosevic, Dijana and Aljančić, Ivana and Šavikin, Katarina and Menkovic, Nebojsa and Radanović, Dragoja and Milosavljević, Slobodan M.",
year = "2009",
abstract = "Xanthone-O-glycosides with 1,3,7,8-oxidation pattern and flavone isoorientin-3'-O-glucoside were isolated from the aerial parts of Gentiana utriculosa. Xanthone-C-glucoside lancerin was detected in Gentiana species for the first time. The distribution of these compounds within the section Calathianae is discussed.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Phytochemical re-investigation of Gentiana utriculosa",
volume = "23",
number = "5",
pages = "466-469",
doi = "10.1080/14786410802079477"
}

Jankovic, T., Krstic-Milosevic, D., Aljančić, I., Šavikin, K., Menkovic, N., Radanović, D.,& Milosavljević, S. M.. (2009). Phytochemical re-investigation of Gentiana utriculosa. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 23(5), 466-469.
https://doi.org/10.1080/14786410802079477

Jankovic T, Krstic-Milosevic D, Aljančić I, Šavikin K, Menkovic N, Radanović D, Milosavljević SM. Phytochemical re-investigation of Gentiana utriculosa. in Natural Product Research. 2009;23(5):466-469.
doi:10.1080/14786410802079477 .

Jankovic, Teodora, Krstic-Milosevic, Dijana, Aljančić, Ivana, Šavikin, Katarina, Menkovic, Nebojsa, Radanović, Dragoja, Milosavljević, Slobodan M., "Phytochemical re-investigation of Gentiana utriculosa" in Natural Product Research, 23, no. 5 (2009):466-469,
https://doi.org/10.1080/14786410802079477 . .

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
PY  - 2008
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/594
AB  - The results of phytochemical investigation, over the last decade, of some wild-growing plant species from Serbia and Montenegro belonging to the families Asteraceae, Guttiferae and Gentianaceae are reported. Most of the investigated species are endemites and the emphasis in this report is on those exhibiting biological activities that could be regarded as the potential sources of drugs. This review comprises 154 compounds, e. g. sesquiterpene lactones and flavonoids (Asteraceae), xanthones, secoiridoids and C-glucoflavonoids (Gentanaceae) and prenylated phloroglucinols (Guttiferae) as well as some other secondary metabolites, produced by the above families, which could be of pharmacological interest.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Pharmaceutical Design
T1  - Some Wild-Growing Plant Species from Serbia and Montenegro as the Potential Sources of Drugs
VL  - 14
IS  - 29
SP  - 3089
EP  - 3105
DO  - 10.2174/138161208786404236
ER  - 

@article{
author = "Aljančić, Ivana and Vajs, Vlatka and Tešević, Vele and Milosavljević, Slobodan M.",
year = "2008",
abstract = "The results of phytochemical investigation, over the last decade, of some wild-growing plant species from Serbia and Montenegro belonging to the families Asteraceae, Guttiferae and Gentianaceae are reported. Most of the investigated species are endemites and the emphasis in this report is on those exhibiting biological activities that could be regarded as the potential sources of drugs. This review comprises 154 compounds, e. g. sesquiterpene lactones and flavonoids (Asteraceae), xanthones, secoiridoids and C-glucoflavonoids (Gentanaceae) and prenylated phloroglucinols (Guttiferae) as well as some other secondary metabolites, produced by the above families, which could be of pharmacological interest.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Pharmaceutical Design",
title = "Some Wild-Growing Plant Species from Serbia and Montenegro as the Potential Sources of Drugs",
volume = "14",
number = "29",
pages = "3089-3105",
doi = "10.2174/138161208786404236"
}

Aljančić, I., Vajs, V., Tešević, V.,& Milosavljević, S. M.. (2008). Some Wild-Growing Plant Species from Serbia and Montenegro as the Potential Sources of Drugs. in Current Pharmaceutical Design
Bentham Science Publ Ltd, Sharjah., 14(29), 3089-3105.
https://doi.org/10.2174/138161208786404236

Aljančić I, Vajs V, Tešević V, Milosavljević SM. Some Wild-Growing Plant Species from Serbia and Montenegro as the Potential Sources of Drugs. in Current Pharmaceutical Design. 2008;14(29):3089-3105.
doi:10.2174/138161208786404236 .

Aljančić, Ivana, Vajs, Vlatka, Tešević, Vele, Milosavljević, Slobodan M., "Some Wild-Growing Plant Species from Serbia and Montenegro as the Potential Sources of Drugs" in Current Pharmaceutical Design, 14, no. 29 (2008):3089-3105,
https://doi.org/10.2174/138161208786404236 . .

TY  - JOUR
AU  - Bulatović, V.M.
AU  - Vajs, Vlatka
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan M.
AU  - Đoković, Dejan
AU  - Petrović, Slobodan D.
PY  - 2006
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/775
AB  - Tanacetum larvatum (Gris.) Kanitz. is an endemic perennial herb distributed on a rocky terrain in Serbia(Kosovo), Montenegro and Albania. The chemical composition of T larvatum essential oil, obtained from two locations in Montenegro (Mt. Komovi [Sample II] and Mt. Prokletije [Sample II]) was investigated. The oils obtained by hydrodistillation were analyzed by GC and GC/MS, on the two different capillary columns. The aerial parts of T. larvatum yielded 0.3% and 0.2% of a yellowish oil (Sample I and Sample II, respectively). About 40 compounds were identified, representing similar to 89% and 96% of the total oil content in the Samples I and II, respectively. tran's-Sabinyl acetate was found to be the dominant component (51.2% and 69.7%). Among the rest of compounds beta-pinene (7.7% and 4.3%) and camphor (6.3% and 4.3%) were the most abundant in both samples.
PB  - Allured Publ Corp, Carol Stream
T2  - Journal of Essential Oil Research
T1  - Chemical composition of Tanacetum larvatum essential oil
VL  - 18
IS  - 2
SP  - 126
EP  - 128
DO  - 10.1080/10412905.2006.9699040
ER  - 

@article{
author = "Bulatović, V.M. and Vajs, Vlatka and Aljančić, Ivana and Milosavljević, Slobodan M. and Đoković, Dejan and Petrović, Slobodan D.",
year = "2006",
abstract = "Tanacetum larvatum (Gris.) Kanitz. is an endemic perennial herb distributed on a rocky terrain in Serbia(Kosovo), Montenegro and Albania. The chemical composition of T larvatum essential oil, obtained from two locations in Montenegro (Mt. Komovi [Sample II] and Mt. Prokletije [Sample II]) was investigated. The oils obtained by hydrodistillation were analyzed by GC and GC/MS, on the two different capillary columns. The aerial parts of T. larvatum yielded 0.3% and 0.2% of a yellowish oil (Sample I and Sample II, respectively). About 40 compounds were identified, representing similar to 89% and 96% of the total oil content in the Samples I and II, respectively. tran's-Sabinyl acetate was found to be the dominant component (51.2% and 69.7%). Among the rest of compounds beta-pinene (7.7% and 4.3%) and camphor (6.3% and 4.3%) were the most abundant in both samples.",
publisher = "Allured Publ Corp, Carol Stream",
journal = "Journal of Essential Oil Research",
title = "Chemical composition of Tanacetum larvatum essential oil",
volume = "18",
number = "2",
pages = "126-128",
doi = "10.1080/10412905.2006.9699040"
}

Bulatović, V.M., Vajs, V., Aljančić, I., Milosavljević, S. M., Đoković, D.,& Petrović, S. D.. (2006). Chemical composition of Tanacetum larvatum essential oil. in Journal of Essential Oil Research
Allured Publ Corp, Carol Stream., 18(2), 126-128.
https://doi.org/10.1080/10412905.2006.9699040

Bulatović V, Vajs V, Aljančić I, Milosavljević SM, Đoković D, Petrović SD. Chemical composition of Tanacetum larvatum essential oil. in Journal of Essential Oil Research. 2006;18(2):126-128.
doi:10.1080/10412905.2006.9699040 .

Bulatović, V.M., Vajs, Vlatka, Aljančić, Ivana, Milosavljević, Slobodan M., Đoković, Dejan, Petrović, Slobodan D., "Chemical composition of Tanacetum larvatum essential oil" in Journal of Essential Oil Research, 18, no. 2 (2006):126-128,
https://doi.org/10.1080/10412905.2006.9699040 . .

TY  - JOUR
AU  - Jankovic, T
AU  - Krstić, Dijana
AU  - Aljančić, Ivana
AU  - Savikin-Fodulovic, K
AU  - Menković, N.
AU  - Vajs, Vlatka
AU  - Milosavljevic, S
PY  - 2005
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/710
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Biochemical Systematics and Ecology
T1  - Xanthones and C-glucosides from the aerial parts of four species of Gentianella from Serbia and Montenegro
VL  - 33
IS  - 7
SP  - 729
EP  - 735
DO  - 10.1016/j.bse.2004.12.010
ER  - 

@article{
author = "Jankovic, T and Krstić, Dijana and Aljančić, Ivana and Savikin-Fodulovic, K and Menković, N. and Vajs, Vlatka and Milosavljevic, S",
year = "2005",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Biochemical Systematics and Ecology",
title = "Xanthones and C-glucosides from the aerial parts of four species of Gentianella from Serbia and Montenegro",
volume = "33",
number = "7",
pages = "729-735",
doi = "10.1016/j.bse.2004.12.010"
}

Jankovic, T., Krstić, D., Aljančić, I., Savikin-Fodulovic, K., Menković, N., Vajs, V.,& Milosavljevic, S.. (2005). Xanthones and C-glucosides from the aerial parts of four species of Gentianella from Serbia and Montenegro. in Biochemical Systematics and Ecology
Pergamon-Elsevier Science Ltd, Oxford., 33(7), 729-735.
https://doi.org/10.1016/j.bse.2004.12.010

Jankovic T, Krstić D, Aljančić I, Savikin-Fodulovic K, Menković N, Vajs V, Milosavljevic S. Xanthones and C-glucosides from the aerial parts of four species of Gentianella from Serbia and Montenegro. in Biochemical Systematics and Ecology. 2005;33(7):729-735.
doi:10.1016/j.bse.2004.12.010 .

Jankovic, T, Krstić, Dijana, Aljančić, Ivana, Savikin-Fodulovic, K, Menković, N., Vajs, Vlatka, Milosavljevic, S, "Xanthones and C-glucosides from the aerial parts of four species of Gentianella from Serbia and Montenegro" in Biochemical Systematics and Ecology, 33, no. 7 (2005):729-735,
https://doi.org/10.1016/j.bse.2004.12.010 . .

TY  - JOUR
AU  - Trifunović, Snežana S.
AU  - Aljančić, Ivana
AU  - Vajs, Vlatka
AU  - Macura, S.
AU  - Milosavljevic, S
PY  - 2005
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/689
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Biochemical Systematics and Ecology
T1  - Sesquiterpene lactones and flavonoids of Achillea depressa
VL  - 33
IS  - 3
SP  - 317
EP  - 322
DO  - 10.1016/j.bse.2004.07.003
ER  - 

@article{
author = "Trifunović, Snežana S. and Aljančić, Ivana and Vajs, Vlatka and Macura, S. and Milosavljevic, S",
year = "2005",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Biochemical Systematics and Ecology",
title = "Sesquiterpene lactones and flavonoids of Achillea depressa",
volume = "33",
number = "3",
pages = "317-322",
doi = "10.1016/j.bse.2004.07.003"
}

Trifunović, S. S., Aljančić, I., Vajs, V., Macura, S.,& Milosavljevic, S.. (2005). Sesquiterpene lactones and flavonoids of Achillea depressa. in Biochemical Systematics and Ecology
Pergamon-Elsevier Science Ltd, Oxford., 33(3), 317-322.
https://doi.org/10.1016/j.bse.2004.07.003

Trifunović SS, Aljančić I, Vajs V, Macura S, Milosavljevic S. Sesquiterpene lactones and flavonoids of Achillea depressa. in Biochemical Systematics and Ecology. 2005;33(3):317-322.
doi:10.1016/j.bse.2004.07.003 .

Trifunović, Snežana S., Aljančić, Ivana, Vajs, Vlatka, Macura, S., Milosavljevic, S, "Sesquiterpene lactones and flavonoids of Achillea depressa" in Biochemical Systematics and Ecology, 33, no. 3 (2005):317-322,
https://doi.org/10.1016/j.bse.2004.07.003 . .

TY  - JOUR
AU  - Krstić, Dijana
AU  - Jankovic, T
AU  - Aljančić, Ivana
AU  - Savikin-Fodulovic, K
AU  - Menković, N.
AU  - Milosavljevic, S
PY  - 2004
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/657
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Biochemical Systematics and Ecology
T1  - Phytochemical investigation of Gentiana dinarica
VL  - 32
IS  - 10
SP  - 937
EP  - 941
DO  - 10.1016/j.bse.2004.03.007
ER  - 

@article{
author = "Krstić, Dijana and Jankovic, T and Aljančić, Ivana and Savikin-Fodulovic, K and Menković, N. and Milosavljevic, S",
year = "2004",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Biochemical Systematics and Ecology",
title = "Phytochemical investigation of Gentiana dinarica",
volume = "32",
number = "10",
pages = "937-941",
doi = "10.1016/j.bse.2004.03.007"
}

Krstić, D., Jankovic, T., Aljančić, I., Savikin-Fodulovic, K., Menković, N.,& Milosavljevic, S.. (2004). Phytochemical investigation of Gentiana dinarica. in Biochemical Systematics and Ecology
Pergamon-Elsevier Science Ltd, Oxford., 32(10), 937-941.
https://doi.org/10.1016/j.bse.2004.03.007

Krstić D, Jankovic T, Aljančić I, Savikin-Fodulovic K, Menković N, Milosavljevic S. Phytochemical investigation of Gentiana dinarica. in Biochemical Systematics and Ecology. 2004;32(10):937-941.
doi:10.1016/j.bse.2004.03.007 .

Krstić, Dijana, Jankovic, T, Aljančić, Ivana, Savikin-Fodulovic, K, Menković, N., Milosavljevic, S, "Phytochemical investigation of Gentiana dinarica" in Biochemical Systematics and Ecology, 32, no. 10 (2004):937-941,
https://doi.org/10.1016/j.bse.2004.03.007 . .