Tran, Thi Anh Thu

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54cbd57f-f868-4b6b-9215-36d5c10581b5
  • Tran, Thi Anh Thu (8)
  • Tran, T. (1)

Author's Bibliography

alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells

Krstić-Ristivojević, Maja; Grundström, Jeanette; Tran, Thi Anh Thu; Apostolović, Danijela; Radoi, Vlad; Starkhammar, Maria; Vukojević, Vesna; Ćirković-Veličković, Tanja; Hamsten, Carl; van Hage, Marianne

(Nature Publishing Group, London, 2018)

TY  - JOUR
AU  - Krstić-Ristivojević, Maja
AU  - Grundström, Jeanette
AU  - Tran, Thi Anh Thu
AU  - Apostolović, Danijela
AU  - Radoi, Vlad
AU  - Starkhammar, Maria
AU  - Vukojević, Vesna
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2207
AB  - Red meat allergy is characterized by an IgE response against the carbohydrate galactose-alpha-1,3-galactose (alpha-Gal), which is abundantly expressed on glycoproteins from non-primate mammals. The mechanisms of how alpha-Gal is processed and presented to the immune system to initiate an allergic reaction are still unknown. The aim of this study was to reveal whether the presence of alpha-Gal epitopes on the protein surface influence antigen uptake and processing in immature monocyte-derived dendritic cells (iMDDCs). Immature MDDCs were prepared from healthy blood donors and red meat allergic patients. We found an increased internalization of alpha-Gal carrying proteins over time in iMDDCs by flow cytometric analysis, which was independent of the donor allergic status. The uptake of alpha-Gal carrying proteins was significantly higher than the uptake of non-alpha-Gal carrying proteins. Confocal microscopy revealed alpha-Gal carrying proteins scattered around the cytoplasm in most iMDDCs while detection of proteins not carrying alpha-Gal was negligible. Fluorescent detection of protein on SDS-PAGE showed that degradation of alpha-Gal carrying proteins was slower than degradation of non-alpha-Gal carrying proteins. Thus, the presence of alpha-Gal on the protein surface affects both uptake and degradation of the protein, and the results add new knowledge of alpha-Gal as a clinically relevant food allergen.
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells
VL  - 8
DO  - 10.1038/s41598-018-30887-8
ER  - 
@article{
author = "Krstić-Ristivojević, Maja and Grundström, Jeanette and Tran, Thi Anh Thu and Apostolović, Danijela and Radoi, Vlad and Starkhammar, Maria and Vukojević, Vesna and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2207",
abstract = "Red meat allergy is characterized by an IgE response against the carbohydrate galactose-alpha-1,3-galactose (alpha-Gal), which is abundantly expressed on glycoproteins from non-primate mammals. The mechanisms of how alpha-Gal is processed and presented to the immune system to initiate an allergic reaction are still unknown. The aim of this study was to reveal whether the presence of alpha-Gal epitopes on the protein surface influence antigen uptake and processing in immature monocyte-derived dendritic cells (iMDDCs). Immature MDDCs were prepared from healthy blood donors and red meat allergic patients. We found an increased internalization of alpha-Gal carrying proteins over time in iMDDCs by flow cytometric analysis, which was independent of the donor allergic status. The uptake of alpha-Gal carrying proteins was significantly higher than the uptake of non-alpha-Gal carrying proteins. Confocal microscopy revealed alpha-Gal carrying proteins scattered around the cytoplasm in most iMDDCs while detection of proteins not carrying alpha-Gal was negligible. Fluorescent detection of protein on SDS-PAGE showed that degradation of alpha-Gal carrying proteins was slower than degradation of non-alpha-Gal carrying proteins. Thus, the presence of alpha-Gal on the protein surface affects both uptake and degradation of the protein, and the results add new knowledge of alpha-Gal as a clinically relevant food allergen.",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells",
volume = "8",
doi = "10.1038/s41598-018-30887-8"
}
Krstić-Ristivojević, M., Grundström, J., Tran, T. A. T., Apostolović, D., Radoi, V., Starkhammar, M., Vukojević, V., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M. (2018). alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells.
Scientific Reports
Nature Publishing Group, London., 8.
https://doi.org/10.1038/s41598-018-30887-8
Krstić-Ristivojević M, Grundström J, Tran TAT, Apostolović D, Radoi V, Starkhammar M, Vukojević V, Ćirković-Veličković T, Hamsten C, van Hage M. alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells. Scientific Reports. 2018;8
Krstić-Ristivojević Maja, Grundström Jeanette, Tran Thi Anh Thu, Apostolović Danijela, Radoi Vlad, Starkhammar Maria, Vukojević Vesna, Ćirković-Veličković Tanja, Hamsten Carl, van Hage Marianne, "alpha-Gal on the protein surface affects uptake and degradation in immature monocyte derived dendritic cells" Scientific Reports, 8 (2018),
https://doi.org/10.1038/s41598-018-30887-8 .
4
7
5
6

Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8

Krstić-Ristivojević, Maja; Grundström, Jeanette; Tran, Thi Anh Thu; Apostolović, Danijela; Radoi, Vlad; Starkhammar, Maria; Vukojević, Vesna; Ćirković-Veličković, Tanja; Hamsten, Carl; van Hage, Marianne

(Nature Publishing Group, London, 2018)

TY  - BOOK
AU  - Krstić-Ristivojević, Maja
AU  - Grundström, Jeanette
AU  - Tran, Thi Anh Thu
AU  - Apostolović, Danijela
AU  - Radoi, Vlad
AU  - Starkhammar, Maria
AU  - Vukojević, Vesna
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3073
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8
ER  - 
@book{
author = "Krstić-Ristivojević, Maja and Grundström, Jeanette and Tran, Thi Anh Thu and Apostolović, Danijela and Radoi, Vlad and Starkhammar, Maria and Vukojević, Vesna and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3073",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8"
}
Krstić-Ristivojević, M., Grundström, J., Tran, T. A. T., Apostolović, D., Radoi, V., Starkhammar, M., Vukojević, V., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M. (2018). Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8.
Scientific Reports
Nature Publishing Group, London..
Krstić-Ristivojević M, Grundström J, Tran TAT, Apostolović D, Radoi V, Starkhammar M, Vukojević V, Ćirković-Veličković T, Hamsten C, van Hage M. Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8. Scientific Reports. 2018;
Krstić-Ristivojević Maja, Grundström Jeanette, Tran Thi Anh Thu, Apostolović Danijela, Radoi Vlad, Starkhammar Maria, Vukojević Vesna, Ćirković-Veličković Tanja, Hamsten Carl, van Hage Marianne, "Supplementary data for the article: Ristivojević, M. K.; Grundström, J.; Tran, T. A. T.; Apostolovic, D.; Radoi, V.; Starkhammar, M.; Vukojević, V.; Ćirković Veličković, T.; Hamsten, C.; van Hage, M. α-Gal on the Protein Surface Affects Uptake and Degradation in Immature Monocyte Derived Dendritic Cells. Scientific Reports 2018, 8 (1). https://doi.org/10.1038/s41598-018-30887-8" Scientific Reports (2018)

Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells

Krstić-Ristivojević, Maja; Apostolović, Danijela; Tran, T.; Grundström, Jeanette; Radoi, Vlad; Vukojević, Vesna; Ćirković-Veličković, Tanja; Hamsten, Carl; van Hage, Marianne

(Wiley, Hoboken, 2017)

TY  - CONF
AU  - Krstić-Ristivojević, Maja
AU  - Apostolović, Danijela
AU  - Tran, T.
AU  - Grundström, Jeanette
AU  - Radoi, Vlad
AU  - Vukojević, Vesna
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2516
PB  - Wiley, Hoboken
C3  - Allergy
T1  - Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells
VL  - 72
SP  - 796
EP  - 796
ER  - 
@conference{
author = "Krstić-Ristivojević, Maja and Apostolović, Danijela and Tran, T. and Grundström, Jeanette and Radoi, Vlad and Vukojević, Vesna and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2516",
publisher = "Wiley, Hoboken",
journal = "Allergy",
title = "Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells",
volume = "72",
pages = "796-796"
}
Krstić-Ristivojević, M., Apostolović, D., Tran, T., Grundström, J., Radoi, V., Vukojević, V., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M. (2017). Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells.
Allergy
Wiley, Hoboken., 72, 796-796.
Krstić-Ristivojević M, Apostolović D, Tran T, Grundström J, Radoi V, Vukojević V, Ćirković-Veličković T, Hamsten C, van Hage M. Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells. Allergy. 2017;72:796-796
Krstić-Ristivojević Maja, Apostolović Danijela, Tran T., Grundström Jeanette, Radoi Vlad, Vukojević Vesna, Ćirković-Veličković Tanja, Hamsten Carl, van Hage Marianne, "Alpha-gal epitope on protein surface affects uptake and degradation in immature monocyte-derived dendritic cells" Allergy, 72 (2017):796-796

In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells

Tran, Thi Anh Thu; Grundström, Jeanette; Krstić-Ristivojević, Maja; Vukojević, Vesna; Apostolović, Danijela; Hamsten, Carl; Gafvelin, Guro; van Hage, Marianne

(Wiley-Blackwell, Hoboken, 2016)

TY  - CONF
AU  - Tran, Thi Anh Thu
AU  - Grundström, Jeanette
AU  - Krstić-Ristivojević, Maja
AU  - Vukojević, Vesna
AU  - Apostolović, Danijela
AU  - Hamsten, Carl
AU  - Gafvelin, Guro
AU  - van Hage, Marianne
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2309
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells
VL  - 71
SP  - 284
EP  - 284
ER  - 
@conference{
author = "Tran, Thi Anh Thu and Grundström, Jeanette and Krstić-Ristivojević, Maja and Vukojević, Vesna and Apostolović, Danijela and Hamsten, Carl and Gafvelin, Guro and van Hage, Marianne",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2309",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells",
volume = "71",
pages = "284-284"
}
Tran, T. A. T., Grundström, J., Krstić-Ristivojević, M., Vukojević, V., Apostolović, D., Hamsten, C., Gafvelin, G.,& van Hage, M. (2016). In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells.
Allergy
Wiley-Blackwell, Hoboken., 71, 284-284.
Tran TAT, Grundström J, Krstić-Ristivojević M, Vukojević V, Apostolović D, Hamsten C, Gafvelin G, van Hage M. In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells. Allergy. 2016;71:284-284
Tran Thi Anh Thu, Grundström Jeanette, Krstić-Ristivojević Maja, Vukojević Vesna, Apostolović Danijela, Hamsten Carl, Gafvelin Guro, van Hage Marianne, "In vitro uptake of alpha-Gal containing protein by human monocyte derived dendritic cells" Allergy, 71 (2016):284-284

Supplementary data for article: Apostolovic, D.; Tran, T. A. T.; Sánchez-Vidaurre, S.; Cirkovic Velickovic, T.; Starkhammar, M.; Hamsten, C.; Van Hage, M. Red Meat Allergic Patients Have a Selective IgE Response to the α-Gal Glycan. Allergy: European Journal of Allergy and Clinical Immunology 2015, 70 (11), 1497–1500. https://doi.org/10.1111/all.12695

Apostolović, Danijela; Tran, Thi Anh Thu; Sanchez-Vidaurre, Sara; Ćirković-Veličković, Tanja; Starkhammar, Maria; Hamsten, Carl; van Hage, Marianne

(Wiley, Hoboken, 2015)

TY  - BOOK
AU  - Apostolović, Danijela
AU  - Tran, Thi Anh Thu
AU  - Sanchez-Vidaurre, Sara
AU  - Ćirković-Veličković, Tanja
AU  - Starkhammar, Maria
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3407
PB  - Wiley, Hoboken
T2  - Allergy
T1  - Supplementary data for article: Apostolovic, D.; Tran, T. A. T.; Sánchez-Vidaurre, S.; Cirkovic Velickovic, T.; Starkhammar, M.; Hamsten, C.; Van Hage, M. Red Meat Allergic Patients Have a Selective IgE Response to the α-Gal Glycan. Allergy: European Journal of Allergy and Clinical Immunology 2015, 70 (11), 1497–1500. https://doi.org/10.1111/all.12695
ER  - 
@book{
author = "Apostolović, Danijela and Tran, Thi Anh Thu and Sanchez-Vidaurre, Sara and Ćirković-Veličković, Tanja and Starkhammar, Maria and Hamsten, Carl and van Hage, Marianne",
year = "2015",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3407",
publisher = "Wiley, Hoboken",
journal = "Allergy",
title = "Supplementary data for article: Apostolovic, D.; Tran, T. A. T.; Sánchez-Vidaurre, S.; Cirkovic Velickovic, T.; Starkhammar, M.; Hamsten, C.; Van Hage, M. Red Meat Allergic Patients Have a Selective IgE Response to the α-Gal Glycan. Allergy: European Journal of Allergy and Clinical Immunology 2015, 70 (11), 1497–1500. https://doi.org/10.1111/all.12695"
}
Apostolović, D., Tran, T. A. T., Sanchez-Vidaurre, S., Ćirković-Veličković, T., Starkhammar, M., Hamsten, C.,& van Hage, M. (2015). Supplementary data for article: Apostolovic, D.; Tran, T. A. T.; Sánchez-Vidaurre, S.; Cirkovic Velickovic, T.; Starkhammar, M.; Hamsten, C.; Van Hage, M. Red Meat Allergic Patients Have a Selective IgE Response to the α-Gal Glycan. Allergy: European Journal of Allergy and Clinical Immunology 2015, 70 (11), 1497–1500. https://doi.org/10.1111/all.12695.
Allergy
Wiley, Hoboken..
Apostolović D, Tran TAT, Sanchez-Vidaurre S, Ćirković-Veličković T, Starkhammar M, Hamsten C, van Hage M. Supplementary data for article: Apostolovic, D.; Tran, T. A. T.; Sánchez-Vidaurre, S.; Cirkovic Velickovic, T.; Starkhammar, M.; Hamsten, C.; Van Hage, M. Red Meat Allergic Patients Have a Selective IgE Response to the α-Gal Glycan. Allergy: European Journal of Allergy and Clinical Immunology 2015, 70 (11), 1497–1500. https://doi.org/10.1111/all.12695. Allergy. 2015;
Apostolović Danijela, Tran Thi Anh Thu, Sanchez-Vidaurre Sara, Ćirković-Veličković Tanja, Starkhammar Maria, Hamsten Carl, van Hage Marianne, "Supplementary data for article: Apostolovic, D.; Tran, T. A. T.; Sánchez-Vidaurre, S.; Cirkovic Velickovic, T.; Starkhammar, M.; Hamsten, C.; Van Hage, M. Red Meat Allergic Patients Have a Selective IgE Response to the α-Gal Glycan. Allergy: European Journal of Allergy and Clinical Immunology 2015, 70 (11), 1497–1500. https://doi.org/10.1111/all.12695" Allergy (2015)

Red meat allergic patients have a selective IgE response to the alpha-Gal glycan

Apostolović, Danijela; Tran, Thi Anh Thu; Sanchez-Vidaurre, Sara; Ćirković-Veličković, Tanja; Starkhammar, Maria; Hamsten, Carl; van Hage, Marianne

(Wiley, Hoboken, 2015)

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Tran, Thi Anh Thu
AU  - Sanchez-Vidaurre, Sara
AU  - Ćirković-Veličković, Tanja
AU  - Starkhammar, Maria
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1982
AB  - Galactose--1,3-galactose (-Gal) is a mammalian carbohydrate with significance in a novel type of food allergy. Patients with IgE against -Gal report severe allergic symptoms 3-6h after consumption of red meat. We investigated whether IgE from red meat allergic patients recognizes other mammalian glycans than -Gal or glycans from the plant kingdom and insects of importance in allergy. We found that none of the 24 red meat allergic patients investigated had an IgE antibody response against the other abundant mammalian glycan N-glycolylneuraminic acid or against cross-reactive carbohydrate determinants from plant or venom sources (nCup a 1, nArt v 1, and MUXF3). Deglycosylation of an -Gal-containing protein, bovine thyroglobulin, significantly reduced the IgE response. In conclusion, we show that red meat allergic patients have a selective IgE response to the -Gal glycan found in red meat. Other common glycans reactive in allergic disease are not targets of red meat allergic patients' IgE.
PB  - Wiley, Hoboken
T2  - Allergy
T1  - Red meat allergic patients have a selective IgE response to the alpha-Gal glycan
VL  - 70
IS  - 11
SP  - 1497
EP  - 1500
DO  - 10.1111/all.12695
ER  - 
@article{
author = "Apostolović, Danijela and Tran, Thi Anh Thu and Sanchez-Vidaurre, Sara and Ćirković-Veličković, Tanja and Starkhammar, Maria and Hamsten, Carl and van Hage, Marianne",
year = "2015",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1982",
abstract = "Galactose--1,3-galactose (-Gal) is a mammalian carbohydrate with significance in a novel type of food allergy. Patients with IgE against -Gal report severe allergic symptoms 3-6h after consumption of red meat. We investigated whether IgE from red meat allergic patients recognizes other mammalian glycans than -Gal or glycans from the plant kingdom and insects of importance in allergy. We found that none of the 24 red meat allergic patients investigated had an IgE antibody response against the other abundant mammalian glycan N-glycolylneuraminic acid or against cross-reactive carbohydrate determinants from plant or venom sources (nCup a 1, nArt v 1, and MUXF3). Deglycosylation of an -Gal-containing protein, bovine thyroglobulin, significantly reduced the IgE response. In conclusion, we show that red meat allergic patients have a selective IgE response to the -Gal glycan found in red meat. Other common glycans reactive in allergic disease are not targets of red meat allergic patients' IgE.",
publisher = "Wiley, Hoboken",
journal = "Allergy",
title = "Red meat allergic patients have a selective IgE response to the alpha-Gal glycan",
volume = "70",
number = "11",
pages = "1497-1500",
doi = "10.1111/all.12695"
}
Apostolović, D., Tran, T. A. T., Sanchez-Vidaurre, S., Ćirković-Veličković, T., Starkhammar, M., Hamsten, C.,& van Hage, M. (2015). Red meat allergic patients have a selective IgE response to the alpha-Gal glycan.
Allergy
Wiley, Hoboken., 70(11), 1497-1500.
https://doi.org/10.1111/all.12695
Apostolović D, Tran TAT, Sanchez-Vidaurre S, Ćirković-Veličković T, Starkhammar M, Hamsten C, van Hage M. Red meat allergic patients have a selective IgE response to the alpha-Gal glycan. Allergy. 2015;70(11):1497-1500
Apostolović Danijela, Tran Thi Anh Thu, Sanchez-Vidaurre Sara, Ćirković-Veličković Tanja, Starkhammar Maria, Hamsten Carl, van Hage Marianne, "Red meat allergic patients have a selective IgE response to the alpha-Gal glycan" Allergy, 70, no. 11 (2015):1497-1500,
https://doi.org/10.1111/all.12695 .
29
18
15
20

Red meat allergy and IgE antibody responses against glycans

Apostolović, Danijela; Tran, Thi Anh Thu; Sanchez-Vidaurre, Sara; Bigdeli, N.; Ćirković-Veličković, Tanja; Hamsten, Carl; van Hage, Marianne

(Wiley-Blackwell, Hoboken, 2015)

TY  - CONF
AU  - Apostolović, Danijela
AU  - Tran, Thi Anh Thu
AU  - Sanchez-Vidaurre, Sara
AU  - Bigdeli, N.
AU  - Ćirković-Veličković, Tanja
AU  - Hamsten, Carl
AU  - van Hage, Marianne
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2046
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - Red meat allergy and IgE antibody responses against glycans
VL  - 70
SP  - 2
EP  - 2
ER  - 
@conference{
author = "Apostolović, Danijela and Tran, Thi Anh Thu and Sanchez-Vidaurre, Sara and Bigdeli, N. and Ćirković-Veličković, Tanja and Hamsten, Carl and van Hage, Marianne",
year = "2015",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2046",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Red meat allergy and IgE antibody responses against glycans",
volume = "70",
pages = "2-2"
}
Apostolović, D., Tran, T. A. T., Sanchez-Vidaurre, S., Bigdeli, N., Ćirković-Veličković, T., Hamsten, C.,& van Hage, M. (2015). Red meat allergy and IgE antibody responses against glycans.
Allergy
Wiley-Blackwell, Hoboken., 70, 2-2.
Apostolović D, Tran TAT, Sanchez-Vidaurre S, Bigdeli N, Ćirković-Veličković T, Hamsten C, van Hage M. Red meat allergy and IgE antibody responses against glycans. Allergy. 2015;70:2-2
Apostolović Danijela, Tran Thi Anh Thu, Sanchez-Vidaurre Sara, Bigdeli N., Ćirković-Veličković Tanja, Hamsten Carl, van Hage Marianne, "Red meat allergy and IgE antibody responses against glycans" Allergy, 70 (2015):2-2

Investigation of galactose-alpha-1,3-galactose epitope and immunoproteomic characterisation of thermally processed beef proteins

Tran, Thi Anh Thu; Apostolović, Danijela; Hamsten, Carl; Starkhammar, Maria; Smiljanić, Katarina; Bigdeli, N.; Ćirković-Veličković, Tanja; van Hage, Marianne

(Wiley-Blackwell, Hoboken, 2014)

TY  - CONF
AU  - Tran, Thi Anh Thu
AU  - Apostolović, Danijela
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - Smiljanić, Katarina
AU  - Bigdeli, N.
AU  - Ćirković-Veličković, Tanja
AU  - van Hage, Marianne
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1836
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - Investigation of galactose-alpha-1,3-galactose epitope and immunoproteomic characterisation of thermally processed beef proteins
VL  - 69
SP  - 209
EP  - 210
ER  - 
@conference{
author = "Tran, Thi Anh Thu and Apostolović, Danijela and Hamsten, Carl and Starkhammar, Maria and Smiljanić, Katarina and Bigdeli, N. and Ćirković-Veličković, Tanja and van Hage, Marianne",
year = "2014",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1836",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Investigation of galactose-alpha-1,3-galactose epitope and immunoproteomic characterisation of thermally processed beef proteins",
volume = "69",
pages = "209-210"
}
Tran, T. A. T., Apostolović, D., Hamsten, C., Starkhammar, M., Smiljanić, K., Bigdeli, N., Ćirković-Veličković, T.,& van Hage, M. (2014). Investigation of galactose-alpha-1,3-galactose epitope and immunoproteomic characterisation of thermally processed beef proteins.
Allergy
Wiley-Blackwell, Hoboken., 69, 209-210.
Tran TAT, Apostolović D, Hamsten C, Starkhammar M, Smiljanić K, Bigdeli N, Ćirković-Veličković T, van Hage M. Investigation of galactose-alpha-1,3-galactose epitope and immunoproteomic characterisation of thermally processed beef proteins. Allergy. 2014;69:209-210
Tran Thi Anh Thu, Apostolović Danijela, Hamsten Carl, Starkhammar Maria, Smiljanić Katarina, Bigdeli N., Ćirković-Veličković Tanja, van Hage Marianne, "Investigation of galactose-alpha-1,3-galactose epitope and immunoproteomic characterisation of thermally processed beef proteins" Allergy, 69 (2014):209-210

Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose-containing allergens

Apostolović, Danijela; Tran, Thi Anh Thu; Hamsten, Carl; Starkhammar, Maria; Ćirković-Veličković, Tanja; van Hage, Marianne

(Wiley, Hoboken, 2014)

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Tran, Thi Anh Thu
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - Ćirković-Veličković, Tanja
AU  - van Hage, Marianne
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1858
AB  - BackgroundRed meat allergy presents a novel form of food allergy with severe delayed allergic reactions where IgE antibodies are directed against the carbohydrate -Gal epitope. Food preparation and processing can influence the allergenicity of proteins. The aim of this study was to characterize the proteomic profile of different beef preparations and to investigate their -Gal reactivity and potential allergenicity. MethodsExtracts from raw, boiled, fried, and medium rare prepared beef were assessed by 2D PAGE for the comparison of protein profiles. IgE-binding proteins were identified using immunoblot-coupled proteomic analysis using sera from red meat-allergic patients. Presence of the -Gal epitope was verified using anti--Gal antibody and IgE inhibition immunoblot with -Gal. ResultsMultiple IgE-binding proteins were detected in the different beef preparations, many of which were also recognized by the anti--Gal antibody. Protein spots reacting with IgE in patient sera were analyzed by MS/MS, resulting in identification of 18 proteins with high identification scores. Seven of the 18 beef allergens identified using meat-allergic patient sera were also recognized by the anti--Gal monoclonal antibody, and four of them were stabile to thermal treatment. Furthermore, a dose-dependent inhibition of red meat-allergic patients' IgE to beef by -Gal was demonstrated. ConclusionsWe show that the -Gal epitope is commonly present in IgE-reactive beef proteins recognized by meat-allergic patients. Seven novel -Gal-containing IgE-binding proteins were identified, of which four were stable to heat treatment. Thus, the allergenicity of red meat proteins is preserved even upon different thermal cooking.
PB  - Wiley, Hoboken
T2  - Allergy
T1  - Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose-containing allergens
VL  - 69
IS  - 10
SP  - 1308
EP  - 1315
DO  - 10.1111/all.12462
ER  - 
@article{
author = "Apostolović, Danijela and Tran, Thi Anh Thu and Hamsten, Carl and Starkhammar, Maria and Ćirković-Veličković, Tanja and van Hage, Marianne",
year = "2014",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1858",
abstract = "BackgroundRed meat allergy presents a novel form of food allergy with severe delayed allergic reactions where IgE antibodies are directed against the carbohydrate -Gal epitope. Food preparation and processing can influence the allergenicity of proteins. The aim of this study was to characterize the proteomic profile of different beef preparations and to investigate their -Gal reactivity and potential allergenicity. MethodsExtracts from raw, boiled, fried, and medium rare prepared beef were assessed by 2D PAGE for the comparison of protein profiles. IgE-binding proteins were identified using immunoblot-coupled proteomic analysis using sera from red meat-allergic patients. Presence of the -Gal epitope was verified using anti--Gal antibody and IgE inhibition immunoblot with -Gal. ResultsMultiple IgE-binding proteins were detected in the different beef preparations, many of which were also recognized by the anti--Gal antibody. Protein spots reacting with IgE in patient sera were analyzed by MS/MS, resulting in identification of 18 proteins with high identification scores. Seven of the 18 beef allergens identified using meat-allergic patient sera were also recognized by the anti--Gal monoclonal antibody, and four of them were stabile to thermal treatment. Furthermore, a dose-dependent inhibition of red meat-allergic patients' IgE to beef by -Gal was demonstrated. ConclusionsWe show that the -Gal epitope is commonly present in IgE-reactive beef proteins recognized by meat-allergic patients. Seven novel -Gal-containing IgE-binding proteins were identified, of which four were stable to heat treatment. Thus, the allergenicity of red meat proteins is preserved even upon different thermal cooking.",
publisher = "Wiley, Hoboken",
journal = "Allergy",
title = "Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose-containing allergens",
volume = "69",
number = "10",
pages = "1308-1315",
doi = "10.1111/all.12462"
}
Apostolović, D., Tran, T. A. T., Hamsten, C., Starkhammar, M., Ćirković-Veličković, T.,& van Hage, M. (2014). Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose-containing allergens.
Allergy
Wiley, Hoboken., 69(10), 1308-1315.
https://doi.org/10.1111/all.12462
Apostolović D, Tran TAT, Hamsten C, Starkhammar M, Ćirković-Veličković T, van Hage M. Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose-containing allergens. Allergy. 2014;69(10):1308-1315
Apostolović Danijela, Tran Thi Anh Thu, Hamsten Carl, Starkhammar Maria, Ćirković-Veličković Tanja, van Hage Marianne, "Immunoproteomics of processed beef proteins reveal novel galactose-alpha-1,3-galactose-containing allergens" Allergy, 69, no. 10 (2014):1308-1315,
https://doi.org/10.1111/all.12462 .
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