Mirkov, Ivana

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orcid::0000-0001-7115-9340
  • Mirkov, Ivana (10)
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Author's Bibliography

Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity

Tucović, Dina; Mirkov, Ivana; Kulaš, Jelena; Željković, Milica; Popović, Dušanka; Zolotarevski, Lidija; Đurđić, Slađana Z.; Mutić, Jelena; Kataranovski, Milena; Popov Aleksandrov, Aleksandra

(Elsevier, 2020)

TY  - JOUR
AU  - Tucović, Dina
AU  - Mirkov, Ivana
AU  - Kulaš, Jelena
AU  - Željković, Milica
AU  - Popović, Dušanka
AU  - Zolotarevski, Lidija
AU  - Đurđić, Slađana Z.
AU  - Mutić, Jelena
AU  - Kataranovski, Milena
AU  - Popov Aleksandrov, Aleksandra
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3815
AB  - Adverse effects of non-occupational exposure to cadmium (Cd) are increasingly acknowledged. Since our previous study has showed that orally acquired Cd affects skin, the contribution of genetic background to dermatotoxicity of oral cadmium was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), which differed in response to chemicals. While similar accumulation of Cd in the skin of both strains was noted, the skin response to the metal differed. DA rat individuals mounted antioxidant enzyme defense in the skin already at lower Cd dose, in contrast to AO rats which reacted to higher metal dose solely (and less pronounced), implying higher susceptibility of DA strain to Cd dermatotoxicity. Epidermal cells from both strains developed stress response, but higher intensity of antioxidant response in AO rats implied this strain`s better ability to defend against Cd insult. Cd induced epidermal cells’ proinflammatory cytokine response only in DA rats. Increased IL-10 seems responsible for the lack of response in AO rats. Differences in the pattern of skin/epidermal cell responsiveness to cadmium give a new insight into repercussion of genetic variability to dermatotoxicity of orally acquired cadmium, bearing relevance for variations in the link between dietary cadmium and inflammation-based skin pathologies.
PB  - Elsevier
T2  - Environmental Toxicology and Pharmacology
T1  - Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity
VL  - 75
DO  - 10.1016/j.etap.2020.103326
ER  - 
@article{
author = "Tucović, Dina and Mirkov, Ivana and Kulaš, Jelena and Željković, Milica and Popović, Dušanka and Zolotarevski, Lidija and Đurđić, Slađana Z. and Mutić, Jelena and Kataranovski, Milena and Popov Aleksandrov, Aleksandra",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3815",
abstract = "Adverse effects of non-occupational exposure to cadmium (Cd) are increasingly acknowledged. Since our previous study has showed that orally acquired Cd affects skin, the contribution of genetic background to dermatotoxicity of oral cadmium was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), which differed in response to chemicals. While similar accumulation of Cd in the skin of both strains was noted, the skin response to the metal differed. DA rat individuals mounted antioxidant enzyme defense in the skin already at lower Cd dose, in contrast to AO rats which reacted to higher metal dose solely (and less pronounced), implying higher susceptibility of DA strain to Cd dermatotoxicity. Epidermal cells from both strains developed stress response, but higher intensity of antioxidant response in AO rats implied this strain`s better ability to defend against Cd insult. Cd induced epidermal cells’ proinflammatory cytokine response only in DA rats. Increased IL-10 seems responsible for the lack of response in AO rats. Differences in the pattern of skin/epidermal cell responsiveness to cadmium give a new insight into repercussion of genetic variability to dermatotoxicity of orally acquired cadmium, bearing relevance for variations in the link between dietary cadmium and inflammation-based skin pathologies.",
publisher = "Elsevier",
journal = "Environmental Toxicology and Pharmacology",
title = "Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity",
volume = "75",
doi = "10.1016/j.etap.2020.103326"
}
Tucović, D., Mirkov, I., Kulaš, J., Željković, M., Popović, D., Zolotarevski, L., Đurđić, S. Z., Mutić, J., Kataranovski, M.,& Popov Aleksandrov, A. (2020). Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity.
Environmental Toxicology and Pharmacology
Elsevier., 75.
https://doi.org/10.1016/j.etap.2020.103326
Tucović D, Mirkov I, Kulaš J, Željković M, Popović D, Zolotarevski L, Đurđić SZ, Mutić J, Kataranovski M, Popov Aleksandrov A. Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity. Environmental Toxicology and Pharmacology. 2020;75
Tucović Dina, Mirkov Ivana, Kulaš Jelena, Željković Milica, Popović Dušanka, Zolotarevski Lidija, Đurđić Slađana Z., Mutić Jelena, Kataranovski Milena, Popov Aleksandrov Aleksandra, "Dermatotoxicity of oral cadmium is strain-dependent and related to differences in skin stress response and inflammatory/immune activity" Environmental Toxicology and Pharmacology, 75 (2020),
https://doi.org/10.1016/j.etap.2020.103326 .
2
1
2

Oral cadmium exposure affects skin immune reactivity in rats

Tucović, Dina; Popov-Aleksandrov, Aleksandra; Mirkov, Ivana; Ninkov, Marina; Kulaš, Jelena; Zolotarevski, Lidija; Vukojević, Vesna; Mutić, Jelena; Tatalović, Nikola; Kataranovski, Milena

(2018)

TY  - JOUR
AU  - Tucović, Dina
AU  - Popov-Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Ninkov, Marina
AU  - Kulaš, Jelena
AU  - Zolotarevski, Lidija
AU  - Vukojević, Vesna
AU  - Mutić, Jelena
AU  - Tatalović, Nikola
AU  - Kataranovski, Milena
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/339
AB  - Skin can acquire cadmium (Cd) by oral route, but there is paucity of data concerning cutaneous effects of this metal. Cd acquired by oral route can affect skin wound healing, but the effect of Cd on other activities involved in skin homeostasis, including skin immunity, are not explored. Using the rat model of 30–day oral administration of Cd (5 ppm and 50 ppm) in drinking water, basic aspects of immune-relevant activity of epidermal cells were examined. Dose-dependent Cd deposition in the the skin was observed (0.035 ± 0.02 µg/g and 0.127 ± 0.04 µg/g at 5 ppm and 50 ppm, respectively, compared to 0.012 ± 0.009 µg/g at 0 ppm of Cd). This resulted in skin inflammation (oxidative stress at both Cd doses and dose-dependent structural changes in the skin and the presence/activation of innate immunity cells). At low Cd dose inflammatory response (nitric oxide and IL-1β) was observed. Other inflammatory cytokines (IL-6 and TNF) response occurred at 50 ppm, which was increased further following skin sensitization with contact allergen dinitro-chlorobenzene (DNCB). Epidermal cells exposed to both Cd doses enhanced concanavalin A (ConA)-stimulated lymphocyte production of IL-17. This study showed for the first time the effect of the metal which gained access to the skin via gut on immune reactivity of epidermal cells. Presented data might be relevant for the link between dietary Cd and the risk of skin pathologies. © 2018 Elsevier Inc.
T2  - Ecotoxicology and Environmental Safety
T1  - Oral cadmium exposure affects skin immune reactivity in rats
VL  - 164
SP  - 12
EP  - 20
DO  - 10.1016/j.ecoenv.2018.07.117
ER  - 
@article{
author = "Tucović, Dina and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Kulaš, Jelena and Zolotarevski, Lidija and Vukojević, Vesna and Mutić, Jelena and Tatalović, Nikola and Kataranovski, Milena",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/339",
abstract = "Skin can acquire cadmium (Cd) by oral route, but there is paucity of data concerning cutaneous effects of this metal. Cd acquired by oral route can affect skin wound healing, but the effect of Cd on other activities involved in skin homeostasis, including skin immunity, are not explored. Using the rat model of 30–day oral administration of Cd (5 ppm and 50 ppm) in drinking water, basic aspects of immune-relevant activity of epidermal cells were examined. Dose-dependent Cd deposition in the the skin was observed (0.035 ± 0.02 µg/g and 0.127 ± 0.04 µg/g at 5 ppm and 50 ppm, respectively, compared to 0.012 ± 0.009 µg/g at 0 ppm of Cd). This resulted in skin inflammation (oxidative stress at both Cd doses and dose-dependent structural changes in the skin and the presence/activation of innate immunity cells). At low Cd dose inflammatory response (nitric oxide and IL-1β) was observed. Other inflammatory cytokines (IL-6 and TNF) response occurred at 50 ppm, which was increased further following skin sensitization with contact allergen dinitro-chlorobenzene (DNCB). Epidermal cells exposed to both Cd doses enhanced concanavalin A (ConA)-stimulated lymphocyte production of IL-17. This study showed for the first time the effect of the metal which gained access to the skin via gut on immune reactivity of epidermal cells. Presented data might be relevant for the link between dietary Cd and the risk of skin pathologies. © 2018 Elsevier Inc.",
journal = "Ecotoxicology and Environmental Safety",
title = "Oral cadmium exposure affects skin immune reactivity in rats",
volume = "164",
pages = "12-20",
doi = "10.1016/j.ecoenv.2018.07.117"
}
Tucović, D., Popov-Aleksandrov, A., Mirkov, I., Ninkov, M., Kulaš, J., Zolotarevski, L., Vukojević, V., Mutić, J., Tatalović, N.,& Kataranovski, M. (2018). Oral cadmium exposure affects skin immune reactivity in rats.
Ecotoxicology and Environmental Safety, 164, 12-20.
https://doi.org/10.1016/j.ecoenv.2018.07.117
Tucović D, Popov-Aleksandrov A, Mirkov I, Ninkov M, Kulaš J, Zolotarevski L, Vukojević V, Mutić J, Tatalović N, Kataranovski M. Oral cadmium exposure affects skin immune reactivity in rats. Ecotoxicology and Environmental Safety. 2018;164:12-20
Tucović Dina, Popov-Aleksandrov Aleksandra, Mirkov Ivana, Ninkov Marina, Kulaš Jelena, Zolotarevski Lidija, Vukojević Vesna, Mutić Jelena, Tatalović Nikola, Kataranovski Milena, "Oral cadmium exposure affects skin immune reactivity in rats" Ecotoxicology and Environmental Safety, 164 (2018):12-20,
https://doi.org/10.1016/j.ecoenv.2018.07.117 .
1
12
8
11

Supplementary data for the article: Stanic-Vucinic, D.; Stojadinovic, M.; Mirkov, I.; Apostolovic, D.; Burazer, L.; Atanaskovic-Markovic, M.; Kataranovski, M.; Cirkovic Velickovic, T. Hypoallergenic Acid-Sensitive Modification Preserves Major Mugwort Allergen Fold and Delivers Full Repertoire of MHC Class II-Binding Peptides during Endolysosomal Degradation. RSC Advances 2016, 6 (91), 88216–88228. https://doi.org/10.1039/c6ra17261j

Stanić-Vučinić, Dragana; Stojadinović, Marija M.; Mirkov, Ivana; Apostolović, Danijela; Burazer, Lidija M.; Atanasković-Marković, Marina; Kataranovski, Milena; Ćirković-Veličković, Tanja

(Royal Soc Chemistry, Cambridge, 2016)

TY  - BOOK
AU  - Stanić-Vučinić, Dragana
AU  - Stojadinović, Marija M.
AU  - Mirkov, Ivana
AU  - Apostolović, Danijela
AU  - Burazer, Lidija M.
AU  - Atanasković-Marković, Marina
AU  - Kataranovski, Milena
AU  - Ćirković-Veličković, Tanja
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3528
PB  - Royal Soc Chemistry, Cambridge
T2  - RSC Advances
T1  - Supplementary data for the article: Stanic-Vucinic, D.; Stojadinovic, M.; Mirkov, I.; Apostolovic, D.; Burazer, L.; Atanaskovic-Markovic, M.; Kataranovski, M.; Cirkovic Velickovic, T. Hypoallergenic Acid-Sensitive Modification Preserves Major Mugwort Allergen Fold and Delivers Full Repertoire of MHC Class II-Binding Peptides during Endolysosomal Degradation. RSC Advances 2016, 6 (91), 88216–88228. https://doi.org/10.1039/c6ra17261j
ER  - 
@book{
author = "Stanić-Vučinić, Dragana and Stojadinović, Marija M. and Mirkov, Ivana and Apostolović, Danijela and Burazer, Lidija M. and Atanasković-Marković, Marina and Kataranovski, Milena and Ćirković-Veličković, Tanja",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3528",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "RSC Advances",
title = "Supplementary data for the article: Stanic-Vucinic, D.; Stojadinovic, M.; Mirkov, I.; Apostolovic, D.; Burazer, L.; Atanaskovic-Markovic, M.; Kataranovski, M.; Cirkovic Velickovic, T. Hypoallergenic Acid-Sensitive Modification Preserves Major Mugwort Allergen Fold and Delivers Full Repertoire of MHC Class II-Binding Peptides during Endolysosomal Degradation. RSC Advances 2016, 6 (91), 88216–88228. https://doi.org/10.1039/c6ra17261j"
}
Stanić-Vučinić, D., Stojadinović, M. M., Mirkov, I., Apostolović, D., Burazer, L. M., Atanasković-Marković, M., Kataranovski, M.,& Ćirković-Veličković, T. (2016). Supplementary data for the article: Stanic-Vucinic, D.; Stojadinovic, M.; Mirkov, I.; Apostolovic, D.; Burazer, L.; Atanaskovic-Markovic, M.; Kataranovski, M.; Cirkovic Velickovic, T. Hypoallergenic Acid-Sensitive Modification Preserves Major Mugwort Allergen Fold and Delivers Full Repertoire of MHC Class II-Binding Peptides during Endolysosomal Degradation. RSC Advances 2016, 6 (91), 88216–88228. https://doi.org/10.1039/c6ra17261j.
RSC Advances
Royal Soc Chemistry, Cambridge..
Stanić-Vučinić D, Stojadinović MM, Mirkov I, Apostolović D, Burazer LM, Atanasković-Marković M, Kataranovski M, Ćirković-Veličković T. Supplementary data for the article: Stanic-Vucinic, D.; Stojadinovic, M.; Mirkov, I.; Apostolovic, D.; Burazer, L.; Atanaskovic-Markovic, M.; Kataranovski, M.; Cirkovic Velickovic, T. Hypoallergenic Acid-Sensitive Modification Preserves Major Mugwort Allergen Fold and Delivers Full Repertoire of MHC Class II-Binding Peptides during Endolysosomal Degradation. RSC Advances 2016, 6 (91), 88216–88228. https://doi.org/10.1039/c6ra17261j. RSC Advances. 2016;
Stanić-Vučinić Dragana, Stojadinović Marija M., Mirkov Ivana, Apostolović Danijela, Burazer Lidija M., Atanasković-Marković Marina, Kataranovski Milena, Ćirković-Veličković Tanja, "Supplementary data for the article: Stanic-Vucinic, D.; Stojadinovic, M.; Mirkov, I.; Apostolovic, D.; Burazer, L.; Atanaskovic-Markovic, M.; Kataranovski, M.; Cirkovic Velickovic, T. Hypoallergenic Acid-Sensitive Modification Preserves Major Mugwort Allergen Fold and Delivers Full Repertoire of MHC Class II-Binding Peptides during Endolysosomal Degradation. RSC Advances 2016, 6 (91), 88216–88228. https://doi.org/10.1039/c6ra17261j" RSC Advances (2016)

Hypoallergenic acid-sensitive modification preserves major mugwort allergen fold and delivers full repertoire of MHC class II-binding peptides during endolysosomal degradation

Stanić-Vučinić, Dragana; Stojadinović, Marija M.; Mirkov, Ivana; Apostolović, Danijela; Burazer, Lidija M.; Atanasković-Marković, Marina; Kataranovski, Milena; Ćirković-Veličković, Tanja

(Royal Soc Chemistry, Cambridge, 2016)

TY  - JOUR
AU  - Stanić-Vučinić, Dragana
AU  - Stojadinović, Marija M.
AU  - Mirkov, Ivana
AU  - Apostolović, Danijela
AU  - Burazer, Lidija M.
AU  - Atanasković-Marković, Marina
AU  - Kataranovski, Milena
AU  - Ćirković-Veličković, Tanja
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2321
AB  - Modified allergens are a safer and more efficient alternative to natural allergens for specific immunotherapy. As the modification of an allergen can diminish its immunogenicity due to the alteration of T-cell epitopes, in this paper we study the effects of a reversible chemical modification of Art v 1, the main allergen of mugwort pollen, on its allergenicity and immunogenicity. Modification of Art v 1 by cis-aconitylation into a polyanionic derivative (CAA) did not result in any significant structural alteration. However, IgE-binding epitopes on CAA were blocked, resulting in a reduced IgE-binding and basophil activation. Both proteins induced proliferation of CD3(+)CD4(+) T-cells in mugwort-allergic patients, but only unmodified allergens increased IL-4, IL-5 and IL-10 production. Rabbit and mouse anti-CAA antibodies exhibited cross-reactivity with native allergens and blocked human IgE-binding to Art v 1. Degradation of CAA by lysosomal fraction enzymes resulted in a similar set of peptides, harboring MHC class II-binding peptides, as unmodified proteins. Thus, cis-aconitylation modified Art v 1 had a significantly reduced allergenicity, whereas its immunogenicity was completely preserved. Acid-environment-responsive modification, which releases a full repertoire of native allergen epitopes within a particular site, can be considered a smart drug delivery system, which is able to deliver a therapeutically-effective dose in a controlled manner, and minimizes adverse side effects.
PB  - Royal Soc Chemistry, Cambridge
T2  - RSC Advances
T1  - Hypoallergenic acid-sensitive modification preserves major mugwort allergen fold and delivers full repertoire of MHC class II-binding peptides during endolysosomal degradation
VL  - 6
IS  - 91
SP  - 88216
EP  - 88228
DO  - 10.1039/c6ra17261j
ER  - 
@article{
author = "Stanić-Vučinić, Dragana and Stojadinović, Marija M. and Mirkov, Ivana and Apostolović, Danijela and Burazer, Lidija M. and Atanasković-Marković, Marina and Kataranovski, Milena and Ćirković-Veličković, Tanja",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2321",
abstract = "Modified allergens are a safer and more efficient alternative to natural allergens for specific immunotherapy. As the modification of an allergen can diminish its immunogenicity due to the alteration of T-cell epitopes, in this paper we study the effects of a reversible chemical modification of Art v 1, the main allergen of mugwort pollen, on its allergenicity and immunogenicity. Modification of Art v 1 by cis-aconitylation into a polyanionic derivative (CAA) did not result in any significant structural alteration. However, IgE-binding epitopes on CAA were blocked, resulting in a reduced IgE-binding and basophil activation. Both proteins induced proliferation of CD3(+)CD4(+) T-cells in mugwort-allergic patients, but only unmodified allergens increased IL-4, IL-5 and IL-10 production. Rabbit and mouse anti-CAA antibodies exhibited cross-reactivity with native allergens and blocked human IgE-binding to Art v 1. Degradation of CAA by lysosomal fraction enzymes resulted in a similar set of peptides, harboring MHC class II-binding peptides, as unmodified proteins. Thus, cis-aconitylation modified Art v 1 had a significantly reduced allergenicity, whereas its immunogenicity was completely preserved. Acid-environment-responsive modification, which releases a full repertoire of native allergen epitopes within a particular site, can be considered a smart drug delivery system, which is able to deliver a therapeutically-effective dose in a controlled manner, and minimizes adverse side effects.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "RSC Advances",
title = "Hypoallergenic acid-sensitive modification preserves major mugwort allergen fold and delivers full repertoire of MHC class II-binding peptides during endolysosomal degradation",
volume = "6",
number = "91",
pages = "88216-88228",
doi = "10.1039/c6ra17261j"
}
Stanić-Vučinić, D., Stojadinović, M. M., Mirkov, I., Apostolović, D., Burazer, L. M., Atanasković-Marković, M., Kataranovski, M.,& Ćirković-Veličković, T. (2016). Hypoallergenic acid-sensitive modification preserves major mugwort allergen fold and delivers full repertoire of MHC class II-binding peptides during endolysosomal degradation.
RSC Advances
Royal Soc Chemistry, Cambridge., 6(91), 88216-88228.
https://doi.org/10.1039/c6ra17261j
Stanić-Vučinić D, Stojadinović MM, Mirkov I, Apostolović D, Burazer LM, Atanasković-Marković M, Kataranovski M, Ćirković-Veličković T. Hypoallergenic acid-sensitive modification preserves major mugwort allergen fold and delivers full repertoire of MHC class II-binding peptides during endolysosomal degradation. RSC Advances. 2016;6(91):88216-88228
Stanić-Vučinić Dragana, Stojadinović Marija M., Mirkov Ivana, Apostolović Danijela, Burazer Lidija M., Atanasković-Marković Marina, Kataranovski Milena, Ćirković-Veličković Tanja, "Hypoallergenic acid-sensitive modification preserves major mugwort allergen fold and delivers full repertoire of MHC class II-binding peptides during endolysosomal degradation" RSC Advances, 6, no. 91 (2016):88216-88228,
https://doi.org/10.1039/c6ra17261j .
1
1
1

Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses

Demenesku, Jelena; Popov-Aleksandrov, Aleksandra; Mirkov, Ivana; Ninkov, Marina; Zolotarevski, Lidija; Kataranovski, Dragan; Brčeski, Ilija; Kataranovski, Milena

(Elsevier Ireland Ltd, Clare, 2016)

TY  - JOUR
AU  - Demenesku, Jelena
AU  - Popov-Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Ninkov, Marina
AU  - Zolotarevski, Lidija
AU  - Kataranovski, Dragan
AU  - Brčeski, Ilija
AU  - Kataranovski, Milena
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2266
AB  - The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
PB  - Elsevier Ireland Ltd, Clare
T2  - Toxicology Letters
T1  - Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses
VL  - 256
SP  - 33
EP  - 43
DO  - 10.1016/j.toxlet.2016.05.022
ER  - 
@article{
author = "Demenesku, Jelena and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Zolotarevski, Lidija and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2266",
abstract = "The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses",
volume = "256",
pages = "33-43",
doi = "10.1016/j.toxlet.2016.05.022"
}
Demenesku, J., Popov-Aleksandrov, A., Mirkov, I., Ninkov, M., Zolotarevski, L., Kataranovski, D., Brčeski, I.,& Kataranovski, M. (2016). Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses.
Toxicology Letters
Elsevier Ireland Ltd, Clare., 256, 33-43.
https://doi.org/10.1016/j.toxlet.2016.05.022
Demenesku J, Popov-Aleksandrov A, Mirkov I, Ninkov M, Zolotarevski L, Kataranovski D, Brčeski I, Kataranovski M. Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses. Toxicology Letters. 2016;256:33-43
Demenesku Jelena, Popov-Aleksandrov Aleksandra, Mirkov Ivana, Ninkov Marina, Zolotarevski Lidija, Kataranovski Dragan, Brčeski Ilija, Kataranovski Milena, "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses" Toxicology Letters, 256 (2016):33-43,
https://doi.org/10.1016/j.toxlet.2016.05.022 .
11
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11

Strain differences in toxicity of oral cadmium intake in rats

Ninkov, Marina; Popov-Aleksandrov, Aleksandra; Mirkov, Ivana; Demenesku, Jelena; Mileusnić, Dina; Jovanović-Stojanov, Sofija; Golić, Nataša; Tolinački, Maja; Zolotarevski, Lidija; Kataranovski, Dragan; Brčeski, Ilija; Kataranovski, Milena

(Pergamon-Elsevier Science Ltd, Oxford, 2016)

TY  - JOUR
AU  - Ninkov, Marina
AU  - Popov-Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Demenesku, Jelena
AU  - Mileusnić, Dina
AU  - Jovanović-Stojanov, Sofija
AU  - Golić, Nataša
AU  - Tolinački, Maja
AU  - Zolotarevski, Lidija
AU  - Kataranovski, Dragan
AU  - Brčeski, Ilija
AU  - Kataranovski, Milena
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2312
AB  - Influence of genetic background on toxicity of oral cadmium (Cd) administration (30 days, in drinking water; 5 ppm and 50 ppm of cadmium) was examined in Albino Oxford (AO) and Dark Agouti (DA) rats. Similar cadmium deposition was noted in gut and draining mesenteric lymph nodes (MLN) of both strains but intensity and/or the pattern of responses to cadmium in these tissues differ. Less intense intestinal damage and leukocyte infiltration was observed in gut of cadmium-exposed AO rats. While gut-associated lymph node cells of DA rats responded to cadmium with an increase of cell proliferation, oxidative activity, IFN-gamma, IL-17 production and expression, no changes of these activities of MLN cells of cadmium-treated AO rats were observed. Spleen, which accumulated cadmium comparable to MLN, responded to metal by drop in cell viability and by reduced responsiveness of proliferation and cytokine production to stimulation in DA rats solely, which suggest tissue dependence of cadmium effects. More pronounced cadmium effects on MLN and spleen cells of DA rats (which accumulated similar cadmium doses as AO rats), showed greater susceptibility of this strain to cadmium. The results presented, for the first time, depict the influence of genetic background to effects of oral cadmium administration. (C) 2016 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Strain differences in toxicity of oral cadmium intake in rats
VL  - 96
SP  - 11
EP  - 23
DO  - 10.1016/j.fct.2016.07.021
ER  - 
@article{
author = "Ninkov, Marina and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Demenesku, Jelena and Mileusnić, Dina and Jovanović-Stojanov, Sofija and Golić, Nataša and Tolinački, Maja and Zolotarevski, Lidija and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2312",
abstract = "Influence of genetic background on toxicity of oral cadmium (Cd) administration (30 days, in drinking water; 5 ppm and 50 ppm of cadmium) was examined in Albino Oxford (AO) and Dark Agouti (DA) rats. Similar cadmium deposition was noted in gut and draining mesenteric lymph nodes (MLN) of both strains but intensity and/or the pattern of responses to cadmium in these tissues differ. Less intense intestinal damage and leukocyte infiltration was observed in gut of cadmium-exposed AO rats. While gut-associated lymph node cells of DA rats responded to cadmium with an increase of cell proliferation, oxidative activity, IFN-gamma, IL-17 production and expression, no changes of these activities of MLN cells of cadmium-treated AO rats were observed. Spleen, which accumulated cadmium comparable to MLN, responded to metal by drop in cell viability and by reduced responsiveness of proliferation and cytokine production to stimulation in DA rats solely, which suggest tissue dependence of cadmium effects. More pronounced cadmium effects on MLN and spleen cells of DA rats (which accumulated similar cadmium doses as AO rats), showed greater susceptibility of this strain to cadmium. The results presented, for the first time, depict the influence of genetic background to effects of oral cadmium administration. (C) 2016 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Strain differences in toxicity of oral cadmium intake in rats",
volume = "96",
pages = "11-23",
doi = "10.1016/j.fct.2016.07.021"
}
Ninkov, M., Popov-Aleksandrov, A., Mirkov, I., Demenesku, J., Mileusnić, D., Jovanović-Stojanov, S., Golić, N., Tolinački, M., Zolotarevski, L., Kataranovski, D., Brčeski, I.,& Kataranovski, M. (2016). Strain differences in toxicity of oral cadmium intake in rats.
Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 96, 11-23.
https://doi.org/10.1016/j.fct.2016.07.021
Ninkov M, Popov-Aleksandrov A, Mirkov I, Demenesku J, Mileusnić D, Jovanović-Stojanov S, Golić N, Tolinački M, Zolotarevski L, Kataranovski D, Brčeski I, Kataranovski M. Strain differences in toxicity of oral cadmium intake in rats. Food and Chemical Toxicology. 2016;96:11-23
Ninkov Marina, Popov-Aleksandrov Aleksandra, Mirkov Ivana, Demenesku Jelena, Mileusnić Dina, Jovanović-Stojanov Sofija, Golić Nataša, Tolinački Maja, Zolotarevski Lidija, Kataranovski Dragan, Brčeski Ilija, Kataranovski Milena, "Strain differences in toxicity of oral cadmium intake in rats" Food and Chemical Toxicology, 96 (2016):11-23,
https://doi.org/10.1016/j.fct.2016.07.021 .
15
12
16

Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses

Demenesku, Jelena; Popov-Aleksandrov, Aleksandra; Mirkov, Ivana; Ninkov, Marina; Zolotarevski, Lidija; Kataranovski, Dragan; Brčeski, Ilija; Kataranovski, Milena

(Elsevier Ireland Ltd, Clare, 2016)

TY  - JOUR
AU  - Demenesku, Jelena
AU  - Popov-Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Ninkov, Marina
AU  - Zolotarevski, Lidija
AU  - Kataranovski, Dragan
AU  - Brčeski, Ilija
AU  - Kataranovski, Milena
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3615
AB  - The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
PB  - Elsevier Ireland Ltd, Clare
T2  - Toxicology Letters
T1  - Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses
VL  - 256
SP  - 33
EP  - 43
DO  - 10.1016/j.toxlet.2016.05.022
ER  - 
@article{
author = "Demenesku, Jelena and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Ninkov, Marina and Zolotarevski, Lidija and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3615",
abstract = "The impact of genetic background on effects of acute i.p. cadmium administration (0.5 mg/kg and 1 mg/kg) on basic immune activity of spleen and lungs was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), known to react differently to chemicals. More pronounced inhibition of Concanavalin A (ConA)-induced and Interleukin (IL)-2 stimulated spleen cell proliferation as well as higher levels of nitric oxide (known to decrease cell's proliferative ability) in DA rats at 1 mg/kg, along with greater inhibition of ConA-induced Interferon (IFN-gamma)-production by total and mononuclear (MNC) spleen cells and IL-17 production by spleen MNC in DA vs. AO rats at this dose show greater susceptibility of this strain to Cd effects on spleen cells response. More pronounced infiltration of neutrophils/CD11b(+) cells to lungs of DA rats treated with 1 mg/kg of Cd and decreased IL-17 lung cell responses noted solely in DA rats speaks in favor of their higher susceptibility to this metal. However, lack of strain disparity in lung cells IFN-gamma responses show that there are regional differences as well. Novel data from this study depict complexity of the influence of genetic background on the effects of cadmium on host immune reactivity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses",
volume = "256",
pages = "33-43",
doi = "10.1016/j.toxlet.2016.05.022"
}
Demenesku, J., Popov-Aleksandrov, A., Mirkov, I., Ninkov, M., Zolotarevski, L., Kataranovski, D., Brčeski, I.,& Kataranovski, M. (2016). Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses.
Toxicology Letters
Elsevier Ireland Ltd, Clare., 256, 33-43.
https://doi.org/10.1016/j.toxlet.2016.05.022
Demenesku J, Popov-Aleksandrov A, Mirkov I, Ninkov M, Zolotarevski L, Kataranovski D, Brčeski I, Kataranovski M. Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses. Toxicology Letters. 2016;256:33-43
Demenesku Jelena, Popov-Aleksandrov Aleksandra, Mirkov Ivana, Ninkov Marina, Zolotarevski Lidija, Kataranovski Dragan, Brčeski Ilija, Kataranovski Milena, "Strain differences of cadmium-induced toxicity in rats: Insight from spleen and lung immune responses" Toxicology Letters, 256 (2016):33-43,
https://doi.org/10.1016/j.toxlet.2016.05.022 .
11
8
11

Toxicity of oral cadmium intake: Impact on gut immunity

Ninkov, Marina; Popov-Aleksandrov, Aleksandra; Demenesku, Jelena; Mirkov, Ivana; Mileusnić, Dina; Petrović, Anja; Grigorov, Ilijana; Zolotarevski, Lidija; Tolinački, Maja; Kataranovski, Dragan; Brčeski, Ilija; Kataranovski, Milena

(Elsevier Ireland Ltd, Clare, 2015)

TY  - JOUR
AU  - Ninkov, Marina
AU  - Popov-Aleksandrov, Aleksandra
AU  - Demenesku, Jelena
AU  - Mirkov, Ivana
AU  - Mileusnić, Dina
AU  - Petrović, Anja
AU  - Grigorov, Ilijana
AU  - Zolotarevski, Lidija
AU  - Tolinački, Maja
AU  - Kataranovski, Dragan
AU  - Brčeski, Ilija
AU  - Kataranovski, Milena
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1730
AB  - Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reduction of bacteria corresponding to Lactobacillus strain, tissue damage and intestinal inflammation [increases in high mobility group box 1 (HMGB1 molecules), superoxide dismutase (SOD) and catalase (CAT) activity and proinflammatory cytokine (TNF, IL-1 beta, IFN-gamma, IL-17) content]. Draining (mesenteric) lymph node (MLN) stress response was observed [elevation of MLN glutathione (GSH) and metallothionein (MT) mRNA levels] and stimulation of both adaptive [cellularity, proliferation, proinflammatory (IFN-gamma and IL-17) MLN cell cytokine responses] as well as innate immune activity (increases in numbers of NK and CD68(+) cells, oxidative activities, IL-1 beta). In contrast to proinflammatory milieu in MLN, decreased or unchanged antiinflammatory IL-10 response was observed. Stimulation of immune activities of MLN cells have, most probably, resulted from sensing of cadmium-induced tissue injury, but also from bacterial antigens that breached compromised intestinal barrier. These effects of cadmium should be taken into account when assessing dietary cadmium as health risk factor. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
PB  - Elsevier Ireland Ltd, Clare
T2  - Toxicology Letters
T1  - Toxicity of oral cadmium intake: Impact on gut immunity
VL  - 237
IS  - 2
SP  - 89
EP  - 99
DO  - 10.1016/j.toxlet.2015.06.002
ER  - 
@article{
author = "Ninkov, Marina and Popov-Aleksandrov, Aleksandra and Demenesku, Jelena and Mirkov, Ivana and Mileusnić, Dina and Petrović, Anja and Grigorov, Ilijana and Zolotarevski, Lidija and Tolinački, Maja and Kataranovski, Dragan and Brčeski, Ilija and Kataranovski, Milena",
year = "2015",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1730",
abstract = "Gastrointestinal tract is one of the main targets of cadmium (Cd), an important food and drinking water contaminant. In the present study, the effect of subchronic (30 days) oral (in water) intake of 5ppm and 50ppm of cadmium on immune responses in the gut was examined in rats. Cadmium consumption resulted in reduction of bacteria corresponding to Lactobacillus strain, tissue damage and intestinal inflammation [increases in high mobility group box 1 (HMGB1 molecules), superoxide dismutase (SOD) and catalase (CAT) activity and proinflammatory cytokine (TNF, IL-1 beta, IFN-gamma, IL-17) content]. Draining (mesenteric) lymph node (MLN) stress response was observed [elevation of MLN glutathione (GSH) and metallothionein (MT) mRNA levels] and stimulation of both adaptive [cellularity, proliferation, proinflammatory (IFN-gamma and IL-17) MLN cell cytokine responses] as well as innate immune activity (increases in numbers of NK and CD68(+) cells, oxidative activities, IL-1 beta). In contrast to proinflammatory milieu in MLN, decreased or unchanged antiinflammatory IL-10 response was observed. Stimulation of immune activities of MLN cells have, most probably, resulted from sensing of cadmium-induced tissue injury, but also from bacterial antigens that breached compromised intestinal barrier. These effects of cadmium should be taken into account when assessing dietary cadmium as health risk factor. (C) 2015 Elsevier Ireland Ltd. All rights reserved.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Toxicity of oral cadmium intake: Impact on gut immunity",
volume = "237",
number = "2",
pages = "89-99",
doi = "10.1016/j.toxlet.2015.06.002"
}
Ninkov, M., Popov-Aleksandrov, A., Demenesku, J., Mirkov, I., Mileusnić, D., Petrović, A., Grigorov, I., Zolotarevski, L., Tolinački, M., Kataranovski, D., Brčeski, I.,& Kataranovski, M. (2015). Toxicity of oral cadmium intake: Impact on gut immunity.
Toxicology Letters
Elsevier Ireland Ltd, Clare., 237(2), 89-99.
https://doi.org/10.1016/j.toxlet.2015.06.002
Ninkov M, Popov-Aleksandrov A, Demenesku J, Mirkov I, Mileusnić D, Petrović A, Grigorov I, Zolotarevski L, Tolinački M, Kataranovski D, Brčeski I, Kataranovski M. Toxicity of oral cadmium intake: Impact on gut immunity. Toxicology Letters. 2015;237(2):89-99
Ninkov Marina, Popov-Aleksandrov Aleksandra, Demenesku Jelena, Mirkov Ivana, Mileusnić Dina, Petrović Anja, Grigorov Ilijana, Zolotarevski Lidija, Tolinački Maja, Kataranovski Dragan, Brčeski Ilija, Kataranovski Milena, "Toxicity of oral cadmium intake: Impact on gut immunity" Toxicology Letters, 237, no. 2 (2015):89-99,
https://doi.org/10.1016/j.toxlet.2015.06.002 .
1
58
49
53

Strain differences in the toxicity of the vitamin K antagonist warfarin in rats

Djokic, Jelena; Ninkov, Marina; Popov-Aleksandrov, Aleksandra; Mirkov, Ivana; Subota, Vesna; Mihajlovic, Luka; Stojadinović, Marija M.; Stanić-Vučinić, Dragana; Kataranovski, Dragan; Kataranovski, Milena

(Serbian Chemical Soc, Belgrade, 2013)

TY  - JOUR
AU  - Djokic, Jelena
AU  - Ninkov, Marina
AU  - Popov-Aleksandrov, Aleksandra
AU  - Mirkov, Ivana
AU  - Subota, Vesna
AU  - Mihajlovic, Luka
AU  - Stojadinović, Marija M.
AU  - Stanić-Vučinić, Dragana
AU  - Kataranovski, Dragan
AU  - Kataranovski, Milena
PY  - 2013
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1624
AB  - Warfarin (3-(alpha-acetonylbenzy1)-4-hydroxy coumarin) is a vitamin K (VK) antagonist that inhibits vitamin K-dependent (VKD) processes, such as blood coagulation. It also exerts an influence on some non-VKD-related activities. In this study, the effect of sub-acute (30-day) oral warfarin (2 and 1 mg L-1) intake on hematological parameters was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), that differ in their sensitivity to certain chemicals. Greater susceptibility to the anticoagulant effect of 2 mg L-1 of warfarin was observed in AO rats and was associated with an increase in the relevant hematological parameters in this strain. Although both strains responded to 2 mg L-1 of warfarin with quantitative changes in the peripheral blood leukocytes, differential bone marrow and lung responses were observed. Strain-related differences in the pro-inflammatory activity of peripheral blood granulocytes and in mononuclear cell IFN-gamma production were observed. Recognition of differences in quantitative and qualitative effects of oral warfarin on processes other than hemostasis might be of relevance for those humans who are on warfarin therapy.
AB  - Varfarin (3-α-acetonilbenzil)-4–hidroksikumarin) je antagonist vitamina K (VK) koji inhibira procese zavisne od ovog vitamina, uključujući koagulaciju krvi. Osim toga, on ispoljava i aktivnosti koje ne zavise od vitamina K kao što su anti-tumorska i imunomodulatorna aktivnost. U ovom radu je ispitan efekat subakutnog (30 dana) oralnog unosa varfarina na hematološke parametre i aktivnost leukocita periferne krvi kod dva soja pacova Albino Oxford (AO) i Dark Agouti (DA) koji se raz- likuju u osetljivosti na iste hemijske agense. Kod jedinki AO soja zapažena je veća smrtnost nakon konzumiranja doze od 4 mg L–1 kao i veća osetljivost na antikoagulantno dejstvo varfarina pri nižim dozama (2 mg L–1) koje je praćeno povećanjem nekih hematoloških parametara. Iako kod jedinki oba soja dolazi do povećanja broja neutrofilnih leukocita periferne krvi pri dozi od 2 mg L–1, promene u osnovnim proinflamatornim aktivnostima ovih ćelija su zapažene samo kod jedinki DA soja. Promene u broju neutrofilnih leukocita u krvi DA jedinki su praćene povećanjem broja granulocitnih prekursora u koštanoj srži, dok prisustvo neutrofila u plućima AO jedinki ukazuje na razmenu ćelija između periferne krvi i plućnog intravaskularnog pula ćelija. Diferencijalne sojno–zavisne promene u aktivnosti mononuklearnih ćelija periferne krvi su takođe zapažene. Razlike u efektu oralno unetog varfarina mogu da imaju implikacije za osobe na oralnoj varfarinskoj terapiji.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Strain differences in the toxicity of the vitamin K antagonist warfarin in rats
T1  - Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova
VL  - 78
IS  - 3
SP  - 381
EP  - 394
DO  - 10.2298/JSC121114010D
ER  - 
@article{
author = "Djokic, Jelena and Ninkov, Marina and Popov-Aleksandrov, Aleksandra and Mirkov, Ivana and Subota, Vesna and Mihajlovic, Luka and Stojadinović, Marija M. and Stanić-Vučinić, Dragana and Kataranovski, Dragan and Kataranovski, Milena",
year = "2013",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1624",
abstract = "Warfarin (3-(alpha-acetonylbenzy1)-4-hydroxy coumarin) is a vitamin K (VK) antagonist that inhibits vitamin K-dependent (VKD) processes, such as blood coagulation. It also exerts an influence on some non-VKD-related activities. In this study, the effect of sub-acute (30-day) oral warfarin (2 and 1 mg L-1) intake on hematological parameters was examined in two rat strains, Albino Oxford (AO) and Dark Agouti (DA), that differ in their sensitivity to certain chemicals. Greater susceptibility to the anticoagulant effect of 2 mg L-1 of warfarin was observed in AO rats and was associated with an increase in the relevant hematological parameters in this strain. Although both strains responded to 2 mg L-1 of warfarin with quantitative changes in the peripheral blood leukocytes, differential bone marrow and lung responses were observed. Strain-related differences in the pro-inflammatory activity of peripheral blood granulocytes and in mononuclear cell IFN-gamma production were observed. Recognition of differences in quantitative and qualitative effects of oral warfarin on processes other than hemostasis might be of relevance for those humans who are on warfarin therapy., Varfarin (3-α-acetonilbenzil)-4–hidroksikumarin) je antagonist vitamina K (VK) koji inhibira procese zavisne od ovog vitamina, uključujući koagulaciju krvi. Osim toga, on ispoljava i aktivnosti koje ne zavise od vitamina K kao što su anti-tumorska i imunomodulatorna aktivnost. U ovom radu je ispitan efekat subakutnog (30 dana) oralnog unosa varfarina na hematološke parametre i aktivnost leukocita periferne krvi kod dva soja pacova Albino Oxford (AO) i Dark Agouti (DA) koji se raz- likuju u osetljivosti na iste hemijske agense. Kod jedinki AO soja zapažena je veća smrtnost nakon konzumiranja doze od 4 mg L–1 kao i veća osetljivost na antikoagulantno dejstvo varfarina pri nižim dozama (2 mg L–1) koje je praćeno povećanjem nekih hematoloških parametara. Iako kod jedinki oba soja dolazi do povećanja broja neutrofilnih leukocita periferne krvi pri dozi od 2 mg L–1, promene u osnovnim proinflamatornim aktivnostima ovih ćelija su zapažene samo kod jedinki DA soja. Promene u broju neutrofilnih leukocita u krvi DA jedinki su praćene povećanjem broja granulocitnih prekursora u koštanoj srži, dok prisustvo neutrofila u plućima AO jedinki ukazuje na razmenu ćelija između periferne krvi i plućnog intravaskularnog pula ćelija. Diferencijalne sojno–zavisne promene u aktivnosti mononuklearnih ćelija periferne krvi su takođe zapažene. Razlike u efektu oralno unetog varfarina mogu da imaju implikacije za osobe na oralnoj varfarinskoj terapiji.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Strain differences in the toxicity of the vitamin K antagonist warfarin in rats, Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova",
volume = "78",
number = "3",
pages = "381-394",
doi = "10.2298/JSC121114010D"
}
Djokic, J., Ninkov, M., Popov-Aleksandrov, A., Mirkov, I., Subota, V., Mihajlovic, L., Stojadinović, M. M., Stanić-Vučinić, D., Kataranovski, D.,& Kataranovski, M. (2013). Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova.
Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 78(3), 381-394.
https://doi.org/10.2298/JSC121114010D
Djokic J, Ninkov M, Popov-Aleksandrov A, Mirkov I, Subota V, Mihajlovic L, Stojadinović MM, Stanić-Vučinić D, Kataranovski D, Kataranovski M. Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova. Journal of the Serbian Chemical Society. 2013;78(3):381-394
Djokic Jelena, Ninkov Marina, Popov-Aleksandrov Aleksandra, Mirkov Ivana, Subota Vesna, Mihajlovic Luka, Stojadinović Marija M., Stanić-Vučinić Dragana, Kataranovski Dragan, Kataranovski Milena, "Sojne razlike u toksičnosti antagoniste vitamina K varfarina kod pacova" Journal of the Serbian Chemical Society, 78, no. 3 (2013):381-394,
https://doi.org/10.2298/JSC121114010D .
3
4
4

Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations

Maksimovic-Ivanic, Danijela; Mijatovic, Sanja; Mirkov, Ivana; Stošić-Grujičić, Stanislava D.; Miljkovic, Djordje; Sabo, Tibor; Trajković, Vladimir S.; Kaluđerović, Goran N.

(Royal Soc Chemistry, Cambridge, 2012)

TY  - JOUR
AU  - Maksimovic-Ivanic, Danijela
AU  - Mijatovic, Sanja
AU  - Mirkov, Ivana
AU  - Stošić-Grujičić, Stanislava D.
AU  - Miljkovic, Djordje
AU  - Sabo, Tibor
AU  - Trajković, Vladimir S.
AU  - Kaluđerović, Goran N.
PY  - 2012
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1551
AB  - Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity.
PB  - Royal Soc Chemistry, Cambridge
T2  - Metallomics
T1  - Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations
VL  - 4
IS  - 11
SP  - 1155
EP  - 1159
DO  - 10.1039/c2mt20150j
ER  - 
@article{
author = "Maksimovic-Ivanic, Danijela and Mijatovic, Sanja and Mirkov, Ivana and Stošić-Grujičić, Stanislava D. and Miljkovic, Djordje and Sabo, Tibor and Trajković, Vladimir S. and Kaluđerović, Goran N.",
year = "2012",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1551",
abstract = "Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Metallomics",
title = "Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations",
volume = "4",
number = "11",
pages = "1155-1159",
doi = "10.1039/c2mt20150j"
}
Maksimovic-Ivanic, D., Mijatovic, S., Mirkov, I., Stošić-Grujičić, S. D., Miljkovic, D., Sabo, T., Trajković, V. S.,& Kaluđerović, G. N. (2012). Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations.
Metallomics
Royal Soc Chemistry, Cambridge., 4(11), 1155-1159.
https://doi.org/10.1039/c2mt20150j
Maksimovic-Ivanic D, Mijatovic S, Mirkov I, Stošić-Grujičić SD, Miljkovic D, Sabo T, Trajković VS, Kaluđerović GN. Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations. Metallomics. 2012;4(11):1155-1159
Maksimovic-Ivanic Danijela, Mijatovic Sanja, Mirkov Ivana, Stošić-Grujičić Stanislava D., Miljkovic Djordje, Sabo Tibor, Trajković Vladimir S., Kaluđerović Goran N., "Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations" Metallomics, 4, no. 11 (2012):1155-1159,
https://doi.org/10.1039/c2mt20150j .
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