Mihajlović-Lalić, Ljiljana

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Authority KeyName Variants
orcid::0000-0003-4802-432X
  • Mihajlović-Lalić, Ljiljana (29)
Projects
Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology Reinforcement of the Faculty of Chemistry, University of Belgrade, towards becoming a Center of Excellence in the region of WB for Molecular Biotechnology and Food research
Molecular properties and modifications of some respiratory and nutritional allergens Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors
Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials Education, Audiovisual and Culture Executive Agency of the European Commission (EACEA)
European Academy for Allergy and Clinical Immunology European Academy for Allergy and Clinical Immunology, COST Action [FA1005]
Hercules Foundation (3D-SPACE: 3D Structural Platform Aiming for Chemical Excellence) [AUGE/11/029] Oxide-based environmentally-friendly porous materials for genotoxic substances removal
Application of advanced oxidation processes and nanostructured oxide materials for the removal of pollutants from the environment, development and optimisation of instrumental techniques for efficiency monitoring Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids
Amorphous and nanostructural chalcogenides NAWI Graz
Research Fund-Flanders (FWO) Hercules Foundation [AUGE/11/029]
Dynamics of nonlinear physicochemical and biochemical systems with modeling and predicting of their behavior under nonequilibrium conditions Advanced multicomponent metal systems and nanostructured materials with diverse functional properties
Molecular mechanisms of physiological and pharmacological control of inflammation and cancer Razvoj novih i poboljšanje postojećih spektroskopskih i elektroanalitičkih metoda za praćenje stanja životne sredine
Research Foundation - Flanders (FWO) [1.5.216.15N]

Author's Bibliography

Synthesis, characterization and cytotoxic activity of organoruthenium(II)-halido complexes with 5-chloro-1H-benzimidazole-2-carboxylic acid

Pantić, Darko N.; Mihajlović-Lalić, Ljiljana; Aranđelović, Sandra; Radulović, Siniša; Grgurić-Šipka, Sanja

(2019)

TY  - JOUR
AU  - Pantić, Darko N.
AU  - Mihajlović-Lalić, Ljiljana
AU  - Aranđelović, Sandra
AU  - Radulović, Siniša
AU  - Grgurić-Šipka, Sanja
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3116
AB  - Three new ruthenium(II)-arene halido complexes, [(η 6 -p-cymene) RuX(L)] (1–3), were synthesized in a reaction of [(η 6 -p-cymene)RuX 2 ] 2 with 5-chloro-1H-benzimidazole-2-carboxylic acid (HL) in ethanol (X – = Cl – (1), Br – (2), I – (3)). The complexes were characterized by elemental analysis, mass spectrometry, IR, 1 H and 13 C NMR spectroscopy. The cytotoxic activity of the ligand precursor and its ruthenium complexes was tested by MTT assay in human cancer cell lines: lung adenocarcinoma (A549), myelogenous leukemia (K562) as well as in one normal human fetal lung fibroblast cell line (MRC-5). The results show that ruthenium(II)-arene complexes possess enhanced cytotoxicity when compared to HL in the range of concentrations up to 300 µM. In terms of halido ligand substitution, cytotoxic activity toward A549 and K562 cell lines in 1–3 serie significantly increased (e.g., IC 50 values for K562: 1: 205.76 µM; 2: 174.77 µM; 3: 83.97 µM). All studied compounds were found to be ineffective toward MRC-5. Hydrolysis of 1–3 was followed by UV-vis spectroscopy at 25 °C, revealing ligand-substitution reactions at the Ru(II) center. Compounds 2 and 3 underwent rapid hydrolysis ranging from a few minutes for the aquation to ca. 20 min, confirming typical Ru-arene behavior in aqueous solutions.
T2  - Journal of Coordination Chemistry
T1  - Synthesis, characterization and cytotoxic activity of organoruthenium(II)-halido complexes with 5-chloro-1H-benzimidazole-2-carboxylic acid
VL  - 72
IS  - 5-7
SP  - 908
EP  - 919
DO  - 10.1080/00958972.2019.1583332
ER  - 
@article{
author = "Pantić, Darko N. and Mihajlović-Lalić, Ljiljana and Aranđelović, Sandra and Radulović, Siniša and Grgurić-Šipka, Sanja",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3116",
abstract = "Three new ruthenium(II)-arene halido complexes, [(η 6 -p-cymene) RuX(L)] (1–3), were synthesized in a reaction of [(η 6 -p-cymene)RuX 2 ] 2 with 5-chloro-1H-benzimidazole-2-carboxylic acid (HL) in ethanol (X – = Cl – (1), Br – (2), I – (3)). The complexes were characterized by elemental analysis, mass spectrometry, IR, 1 H and 13 C NMR spectroscopy. The cytotoxic activity of the ligand precursor and its ruthenium complexes was tested by MTT assay in human cancer cell lines: lung adenocarcinoma (A549), myelogenous leukemia (K562) as well as in one normal human fetal lung fibroblast cell line (MRC-5). The results show that ruthenium(II)-arene complexes possess enhanced cytotoxicity when compared to HL in the range of concentrations up to 300 µM. In terms of halido ligand substitution, cytotoxic activity toward A549 and K562 cell lines in 1–3 serie significantly increased (e.g., IC 50 values for K562: 1: 205.76 µM; 2: 174.77 µM; 3: 83.97 µM). All studied compounds were found to be ineffective toward MRC-5. Hydrolysis of 1–3 was followed by UV-vis spectroscopy at 25 °C, revealing ligand-substitution reactions at the Ru(II) center. Compounds 2 and 3 underwent rapid hydrolysis ranging from a few minutes for the aquation to ca. 20 min, confirming typical Ru-arene behavior in aqueous solutions.",
journal = "Journal of Coordination Chemistry",
title = "Synthesis, characterization and cytotoxic activity of organoruthenium(II)-halido complexes with 5-chloro-1H-benzimidazole-2-carboxylic acid",
volume = "72",
number = "5-7",
pages = "908-919",
doi = "10.1080/00958972.2019.1583332"
}
Pantić, D. N., Mihajlović-Lalić, L., Aranđelović, S., Radulović, S.,& Grgurić-Šipka, S. (2019). Synthesis, characterization and cytotoxic activity of organoruthenium(II)-halido complexes with 5-chloro-1H-benzimidazole-2-carboxylic acid.
Journal of Coordination Chemistry, 72(5-7), 908-919.
https://doi.org/10.1080/00958972.2019.1583332
Pantić DN, Mihajlović-Lalić L, Aranđelović S, Radulović S, Grgurić-Šipka S. Synthesis, characterization and cytotoxic activity of organoruthenium(II)-halido complexes with 5-chloro-1H-benzimidazole-2-carboxylic acid. Journal of Coordination Chemistry. 2019;72(5-7):908-919
Pantić Darko N., Mihajlović-Lalić Ljiljana, Aranđelović Sandra, Radulović Siniša, Grgurić-Šipka Sanja, "Synthesis, characterization and cytotoxic activity of organoruthenium(II)-halido complexes with 5-chloro-1H-benzimidazole-2-carboxylic acid" Journal of Coordination Chemistry, 72, no. 5-7 (2019):908-919,
https://doi.org/10.1080/00958972.2019.1583332 .
2
2
3

Supplementary material for the article: Pantić, D. N.; Mihajlović-Lalić, L. E.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S. Synthesis, Characterization and Cytotoxic Activity of Organoruthenium(II)-Halido Complexes with 5-Chloro-1H-Benzimidazole-2-Carboxylic Acid. Journal of Coordination Chemistry 2019, 72 (5–7), 908–919. https://doi.org/10.1080/00958972.2019.1583332

Pantić, Darko N.; Mihajlović-Lalić, Ljiljana; Aranđelović, Sandra; Radulović, Siniša; Grgurić-Šipka, Sanja

(2019)

TY  - BOOK
AU  - Pantić, Darko N.
AU  - Mihajlović-Lalić, Ljiljana
AU  - Aranđelović, Sandra
AU  - Radulović, Siniša
AU  - Grgurić-Šipka, Sanja
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3117
T2  - Journal of Coordination Chemistry
T1  - Supplementary material for the article:
Pantić, D. N.; Mihajlović-Lalić, L. E.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S.
Synthesis, Characterization and Cytotoxic Activity of Organoruthenium(II)-Halido Complexes
with 5-Chloro-1H-Benzimidazole-2-Carboxylic Acid. Journal of Coordination Chemistry 2019,
72 (5–7), 908–919. https://doi.org/10.1080/00958972.2019.1583332
ER  - 
@book{
author = "Pantić, Darko N. and Mihajlović-Lalić, Ljiljana and Aranđelović, Sandra and Radulović, Siniša and Grgurić-Šipka, Sanja",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3117",
journal = "Journal of Coordination Chemistry",
title = "Supplementary material for the article:
Pantić, D. N.; Mihajlović-Lalić, L. E.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S.
Synthesis, Characterization and Cytotoxic Activity of Organoruthenium(II)-Halido Complexes
with 5-Chloro-1H-Benzimidazole-2-Carboxylic Acid. Journal of Coordination Chemistry 2019,
72 (5–7), 908–919. https://doi.org/10.1080/00958972.2019.1583332"
}
Pantić, D. N., Mihajlović-Lalić, L., Aranđelović, S., Radulović, S.,& Grgurić-Šipka, S. (2019). Supplementary material for the article:
Pantić, D. N.; Mihajlović-Lalić, L. E.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S.
Synthesis, Characterization and Cytotoxic Activity of Organoruthenium(II)-Halido Complexes
with 5-Chloro-1H-Benzimidazole-2-Carboxylic Acid. Journal of Coordination Chemistry 2019,
72 (5–7), 908–919. https://doi.org/10.1080/00958972.2019.1583332.
Journal of Coordination Chemistry.
Pantić DN, Mihajlović-Lalić L, Aranđelović S, Radulović S, Grgurić-Šipka S. Supplementary material for the article:
Pantić, D. N.; Mihajlović-Lalić, L. E.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S.
Synthesis, Characterization and Cytotoxic Activity of Organoruthenium(II)-Halido Complexes
with 5-Chloro-1H-Benzimidazole-2-Carboxylic Acid. Journal of Coordination Chemistry 2019,
72 (5–7), 908–919. https://doi.org/10.1080/00958972.2019.1583332. Journal of Coordination Chemistry. 2019;
Pantić Darko N., Mihajlović-Lalić Ljiljana, Aranđelović Sandra, Radulović Siniša, Grgurić-Šipka Sanja, "Supplementary material for the article:
Pantić, D. N.; Mihajlović-Lalić, L. E.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S.
Synthesis, Characterization and Cytotoxic Activity of Organoruthenium(II)-Halido Complexes
with 5-Chloro-1H-Benzimidazole-2-Carboxylic Acid. Journal of Coordination Chemistry 2019,
72 (5–7), 908–919. https://doi.org/10.1080/00958972.2019.1583332" Journal of Coordination Chemistry (2019)

Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity

Nikolić, Stefan; Mihajlović-Lalić, Ljiljana; Vidosavljević, Marija; Aranđelović, Sandra; Radulović, Siniša; Grgurić-Šipka, Sanja

(2019)

TY  - JOUR
AU  - Nikolić, Stefan
AU  - Mihajlović-Lalić, Ljiljana
AU  - Vidosavljević, Marija
AU  - Aranđelović, Sandra
AU  - Radulović, Siniša
AU  - Grgurić-Šipka, Sanja
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3640
AB  - Four mono- (1–4) and four binuclear Ru(II) arene (5–8) complexes have been isolated from the reaction of [Ru(η6-benzene)Cl(μ-Cl)]2 or [Ru(η6-toluene)Cl(μ-Cl)]2 with 2-pyridinecarboxylic acid and 6-fluoro-2-pyridinecarboxylic acid. Their structural characterization included IR and NMR spectroscopy and MS spectrometry. The cytotoxic potential of the compounds has been tested by MTT assay in seven human cancer cell lines: alveolar basal adenocarcinoma (A549), large cell lung carcinoma (HTB177), colorectal carcinoma (HCT116), malignant melanoma (A375), prostate adenocarcinoma (PC3), breast carcinoma (MDA-MB-453), cervix adenocarcinoma (HeLa), and one human non-malignant lung fibroblast cell line (MRC-5). Mononuclear complexes 1 and 3 carrying 2-pyridinecarboxylic acid have displayed moderate antiproliferative effect toward HCT116 and HeLa, slightly better in comparison to their binuclear analogues, 5 and 7. The highest activity and cytoselectivity has been observed 1 as it has reduced viability of HCT116 cells 1.5 times more efficiently (IC50 = 27.5 μM), than of the MRC-5 cells (IC50 = 41.3 μM). In contrast to 1 and 3, compounds 2, 4–8 have been found to exhibit lack of cytotoxicity or mild cytotoxicity with IC50 values ranging from 100 to 300 μM.
T2  - Journal of Organometallic Chemistry
T1  - Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity
VL  - 902
DO  - 10.1016/j.jorganchem.2019.120966
ER  - 
@article{
author = "Nikolić, Stefan and Mihajlović-Lalić, Ljiljana and Vidosavljević, Marija and Aranđelović, Sandra and Radulović, Siniša and Grgurić-Šipka, Sanja",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3640",
abstract = "Four mono- (1–4) and four binuclear Ru(II) arene (5–8) complexes have been isolated from the reaction of [Ru(η6-benzene)Cl(μ-Cl)]2 or [Ru(η6-toluene)Cl(μ-Cl)]2 with 2-pyridinecarboxylic acid and 6-fluoro-2-pyridinecarboxylic acid. Their structural characterization included IR and NMR spectroscopy and MS spectrometry. The cytotoxic potential of the compounds has been tested by MTT assay in seven human cancer cell lines: alveolar basal adenocarcinoma (A549), large cell lung carcinoma (HTB177), colorectal carcinoma (HCT116), malignant melanoma (A375), prostate adenocarcinoma (PC3), breast carcinoma (MDA-MB-453), cervix adenocarcinoma (HeLa), and one human non-malignant lung fibroblast cell line (MRC-5). Mononuclear complexes 1 and 3 carrying 2-pyridinecarboxylic acid have displayed moderate antiproliferative effect toward HCT116 and HeLa, slightly better in comparison to their binuclear analogues, 5 and 7. The highest activity and cytoselectivity has been observed 1 as it has reduced viability of HCT116 cells 1.5 times more efficiently (IC50 = 27.5 μM), than of the MRC-5 cells (IC50 = 41.3 μM). In contrast to 1 and 3, compounds 2, 4–8 have been found to exhibit lack of cytotoxicity or mild cytotoxicity with IC50 values ranging from 100 to 300 μM.",
journal = "Journal of Organometallic Chemistry",
title = "Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity",
volume = "902",
doi = "10.1016/j.jorganchem.2019.120966"
}
Nikolić, S., Mihajlović-Lalić, L., Vidosavljević, M., Aranđelović, S., Radulović, S.,& Grgurić-Šipka, S. (2019). Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity.
Journal of Organometallic Chemistry, 902.
https://doi.org/10.1016/j.jorganchem.2019.120966
Nikolić S, Mihajlović-Lalić L, Vidosavljević M, Aranđelović S, Radulović S, Grgurić-Šipka S. Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity. Journal of Organometallic Chemistry. 2019;902
Nikolić Stefan, Mihajlović-Lalić Ljiljana, Vidosavljević Marija, Aranđelović Sandra, Radulović Siniša, Grgurić-Šipka Sanja, "Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity" Journal of Organometallic Chemistry, 902 (2019),
https://doi.org/10.1016/j.jorganchem.2019.120966 .
2
1
2

Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity

Nikolić, Stefan; Mihajlović-Lalić, Ljiljana; Vidosavljević, Marija; Aranđelović, Sandra; Radulović, Siniša; Grgurić-Šipka, Sanja

(2019)

TY  - JOUR
AU  - Nikolić, Stefan
AU  - Mihajlović-Lalić, Ljiljana
AU  - Vidosavljević, Marija
AU  - Aranđelović, Sandra
AU  - Radulović, Siniša
AU  - Grgurić-Šipka, Sanja
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3641
AB  - Four mono- (1–4) and four binuclear Ru(II) arene (5–8) complexes have been isolated from the reaction of [Ru(η6-benzene)Cl(μ-Cl)]2 or [Ru(η6-toluene)Cl(μ-Cl)]2 with 2-pyridinecarboxylic acid and 6-fluoro-2-pyridinecarboxylic acid. Their structural characterization included IR and NMR spectroscopy and MS spectrometry. The cytotoxic potential of the compounds has been tested by MTT assay in seven human cancer cell lines: alveolar basal adenocarcinoma (A549), large cell lung carcinoma (HTB177), colorectal carcinoma (HCT116), malignant melanoma (A375), prostate adenocarcinoma (PC3), breast carcinoma (MDA-MB-453), cervix adenocarcinoma (HeLa), and one human non-malignant lung fibroblast cell line (MRC-5). Mononuclear complexes 1 and 3 carrying 2-pyridinecarboxylic acid have displayed moderate antiproliferative effect toward HCT116 and HeLa, slightly better in comparison to their binuclear analogues, 5 and 7. The highest activity and cytoselectivity has been observed 1 as it has reduced viability of HCT116 cells 1.5 times more efficiently (IC50 = 27.5 μM), than of the MRC-5 cells (IC50 = 41.3 μM). In contrast to 1 and 3, compounds 2, 4–8 have been found to exhibit lack of cytotoxicity or mild cytotoxicity with IC50 values ranging from 100 to 300 μM.
T2  - Journal of Organometallic Chemistry
T1  - Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity
VL  - 902
DO  - 10.1016/j.jorganchem.2019.120966
ER  - 
@article{
author = "Nikolić, Stefan and Mihajlović-Lalić, Ljiljana and Vidosavljević, Marija and Aranđelović, Sandra and Radulović, Siniša and Grgurić-Šipka, Sanja",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3641",
abstract = "Four mono- (1–4) and four binuclear Ru(II) arene (5–8) complexes have been isolated from the reaction of [Ru(η6-benzene)Cl(μ-Cl)]2 or [Ru(η6-toluene)Cl(μ-Cl)]2 with 2-pyridinecarboxylic acid and 6-fluoro-2-pyridinecarboxylic acid. Their structural characterization included IR and NMR spectroscopy and MS spectrometry. The cytotoxic potential of the compounds has been tested by MTT assay in seven human cancer cell lines: alveolar basal adenocarcinoma (A549), large cell lung carcinoma (HTB177), colorectal carcinoma (HCT116), malignant melanoma (A375), prostate adenocarcinoma (PC3), breast carcinoma (MDA-MB-453), cervix adenocarcinoma (HeLa), and one human non-malignant lung fibroblast cell line (MRC-5). Mononuclear complexes 1 and 3 carrying 2-pyridinecarboxylic acid have displayed moderate antiproliferative effect toward HCT116 and HeLa, slightly better in comparison to their binuclear analogues, 5 and 7. The highest activity and cytoselectivity has been observed 1 as it has reduced viability of HCT116 cells 1.5 times more efficiently (IC50 = 27.5 μM), than of the MRC-5 cells (IC50 = 41.3 μM). In contrast to 1 and 3, compounds 2, 4–8 have been found to exhibit lack of cytotoxicity or mild cytotoxicity with IC50 values ranging from 100 to 300 μM.",
journal = "Journal of Organometallic Chemistry",
title = "Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity",
volume = "902",
doi = "10.1016/j.jorganchem.2019.120966"
}
Nikolić, S., Mihajlović-Lalić, L., Vidosavljević, M., Aranđelović, S., Radulović, S.,& Grgurić-Šipka, S. (2019). Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity.
Journal of Organometallic Chemistry, 902.
https://doi.org/10.1016/j.jorganchem.2019.120966
Nikolić S, Mihajlović-Lalić L, Vidosavljević M, Aranđelović S, Radulović S, Grgurić-Šipka S. Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity. Journal of Organometallic Chemistry. 2019;902
Nikolić Stefan, Mihajlović-Lalić Ljiljana, Vidosavljević Marija, Aranđelović Sandra, Radulović Siniša, Grgurić-Šipka Sanja, "Mono- and binuclear Ru(II) arene complexes with (fluoro substituted) picolinic acid: Synthesis, characterization and cytotoxicity" Journal of Organometallic Chemistry, 902 (2019),
https://doi.org/10.1016/j.jorganchem.2019.120966 .
2
1
2

Supplementary data for the article: Nikolić, S.; Mihajlović-Lalić, L. E.; Vidosavljević, M.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S. Mono- and Binuclear Ru(II) Arene Complexes with (Fluoro Substituted) Picolinic Acid: Synthesis, Characterization and Cytotoxicity. Journal of Organometallic Chemistry 2019, 902. https://doi.org/10.1016/j.jorganchem.2019.120966

Nikolić, Stefan; Mihajlović-Lalić, Ljiljana; Vidosavljević, Marija; Aranđelović, Sandra; Radulović, Siniša; Grgurić-Šipka, Sanja

(2019)

TY  - BOOK
AU  - Nikolić, Stefan
AU  - Mihajlović-Lalić, Ljiljana
AU  - Vidosavljević, Marija
AU  - Aranđelović, Sandra
AU  - Radulović, Siniša
AU  - Grgurić-Šipka, Sanja
PY  - 2019
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3642
T2  - Journal of Organometallic Chemistry
T1  - Supplementary data for the article: Nikolić, S.; Mihajlović-Lalić, L. E.; Vidosavljević, M.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S. Mono- and Binuclear Ru(II) Arene Complexes with (Fluoro Substituted) Picolinic Acid: Synthesis, Characterization and Cytotoxicity. Journal of Organometallic Chemistry 2019, 902. https://doi.org/10.1016/j.jorganchem.2019.120966
VL  - 902
ER  - 
@book{
author = "Nikolić, Stefan and Mihajlović-Lalić, Ljiljana and Vidosavljević, Marija and Aranđelović, Sandra and Radulović, Siniša and Grgurić-Šipka, Sanja",
year = "2019",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3642",
journal = "Journal of Organometallic Chemistry",
title = "Supplementary data for the article: Nikolić, S.; Mihajlović-Lalić, L. E.; Vidosavljević, M.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S. Mono- and Binuclear Ru(II) Arene Complexes with (Fluoro Substituted) Picolinic Acid: Synthesis, Characterization and Cytotoxicity. Journal of Organometallic Chemistry 2019, 902. https://doi.org/10.1016/j.jorganchem.2019.120966",
volume = "902"
}
Nikolić, S., Mihajlović-Lalić, L., Vidosavljević, M., Aranđelović, S., Radulović, S.,& Grgurić-Šipka, S. (2019). Supplementary data for the article: Nikolić, S.; Mihajlović-Lalić, L. E.; Vidosavljević, M.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S. Mono- and Binuclear Ru(II) Arene Complexes with (Fluoro Substituted) Picolinic Acid: Synthesis, Characterization and Cytotoxicity. Journal of Organometallic Chemistry 2019, 902. https://doi.org/10.1016/j.jorganchem.2019.120966.
Journal of Organometallic Chemistry, 902.
Nikolić S, Mihajlović-Lalić L, Vidosavljević M, Aranđelović S, Radulović S, Grgurić-Šipka S. Supplementary data for the article: Nikolić, S.; Mihajlović-Lalić, L. E.; Vidosavljević, M.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S. Mono- and Binuclear Ru(II) Arene Complexes with (Fluoro Substituted) Picolinic Acid: Synthesis, Characterization and Cytotoxicity. Journal of Organometallic Chemistry 2019, 902. https://doi.org/10.1016/j.jorganchem.2019.120966. Journal of Organometallic Chemistry. 2019;902
Nikolić Stefan, Mihajlović-Lalić Ljiljana, Vidosavljević Marija, Aranđelović Sandra, Radulović Siniša, Grgurić-Šipka Sanja, "Supplementary data for the article: Nikolić, S.; Mihajlović-Lalić, L. E.; Vidosavljević, M.; Aranđelović, S.; Radulović, S.; Grgurić-Šipka, S. Mono- and Binuclear Ru(II) Arene Complexes with (Fluoro Substituted) Picolinic Acid: Synthesis, Characterization and Cytotoxicity. Journal of Organometallic Chemistry 2019, 902. https://doi.org/10.1016/j.jorganchem.2019.120966" Journal of Organometallic Chemistry, 902 (2019)

Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands

Mihajlović-Lalić, Ljiljana; Stanković, Dalibor; Poljarević, Jelena; Sabo, Tibor; Manojlović, Dragan D.

(Electrochemical Soc Inc, Pennington, 2018)

TY  - JOUR
AU  - Mihajlović-Lalić, Ljiljana
AU  - Stanković, Dalibor
AU  - Poljarević, Jelena
AU  - Sabo, Tibor
AU  - Manojlović, Dragan D.
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2196
AB  - The electrochemical behavior of four dialkyl esters (methyl, ethyl, n-propyl and n-butyl) of (S,S)-alpha,alpha'-(1,2-ethanediyldiimino)-bis[cyclohexanepropanoic acid] with moderate antitumor activity has been studied by cyclic voltammetry. I-E curves recorded at boron-doped diamond electrode in -2.00  lt  E-p  lt  0.00 V range show a single oxidative peak located in the -0.95  lt  E-p,E-a  lt  -0.52 V region in a form of one-electron wave. The electrochemical processes appear to be irreversible for all compounds except for the compound with methyl substituent which demonstrates well-defined reversible electron transfer. Derivatives with bulkier moieties are easier to oxidize. For all investigated compounds an amine-centered redox process is dominant. Further investigation indicates that electrochemical reaction is diffusion controlled, chemically irreversible process. The results are discussed in terms of linking their electrochemical activity to antitumor effect. (C) 2018 The Electrochemical Society.
PB  - Electrochemical Soc Inc, Pennington
T2  - Journal of the Electrochemical Society
T1  - Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands
VL  - 165
IS  - 10
DO  - 10.1149/2.1121810jes
ER  - 
@article{
author = "Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Poljarević, Jelena and Sabo, Tibor and Manojlović, Dragan D.",
year = "2018",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2196",
abstract = "The electrochemical behavior of four dialkyl esters (methyl, ethyl, n-propyl and n-butyl) of (S,S)-alpha,alpha'-(1,2-ethanediyldiimino)-bis[cyclohexanepropanoic acid] with moderate antitumor activity has been studied by cyclic voltammetry. I-E curves recorded at boron-doped diamond electrode in -2.00  lt  E-p  lt  0.00 V range show a single oxidative peak located in the -0.95  lt  E-p,E-a  lt  -0.52 V region in a form of one-electron wave. The electrochemical processes appear to be irreversible for all compounds except for the compound with methyl substituent which demonstrates well-defined reversible electron transfer. Derivatives with bulkier moieties are easier to oxidize. For all investigated compounds an amine-centered redox process is dominant. Further investigation indicates that electrochemical reaction is diffusion controlled, chemically irreversible process. The results are discussed in terms of linking their electrochemical activity to antitumor effect. (C) 2018 The Electrochemical Society.",
publisher = "Electrochemical Soc Inc, Pennington",
journal = "Journal of the Electrochemical Society",
title = "Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands",
volume = "165",
number = "10",
doi = "10.1149/2.1121810jes"
}
Mihajlović-Lalić, L., Stanković, D., Poljarević, J., Sabo, T.,& Manojlović, D. D. (2018). Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands.
Journal of the Electrochemical Society
Electrochemical Soc Inc, Pennington., 165(10).
https://doi.org/10.1149/2.1121810jes
Mihajlović-Lalić L, Stanković D, Poljarević J, Sabo T, Manojlović DD. Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands. Journal of the Electrochemical Society. 2018;165(10)
Mihajlović-Lalić Ljiljana, Stanković Dalibor, Poljarević Jelena, Sabo Tibor, Manojlović Dragan D., "Voltammetric Study of Antitumor Efficient Ethylenediamine-Type of Ligands" Journal of the Electrochemical Society, 165, no. 10 (2018),
https://doi.org/10.1149/2.1121810jes .

Supplementary data for article: Baroud, A. A.; Mihajlović-Lalić, L. E.; Gligorijević, N.; Aranđelović, S.; Stanković, D.; Radulović, S.; Van Hecke, K.; Savić, A.; Grgurić-Šipka, S. Ruthenium(II) Bipyridine Complexes: From Synthesis and Crystal Structures to Electrochemical and Cytotoxicity Investigation. Journal of Coordination Chemistry 2017, 70 (5), 831–847. https://doi.org/10.1080/00958972.2017.1282611

Baroud, Afya A.; Mihajlović-Lalić, Ljiljana; Gligorijević, Nevenka; Aranđelović, Sandra; Stanković, Dalibor; Radulović, Siniša; Van Hecke, Kristof; Savić, Aleksandar; Grgurić-Šipka, Sanja

(Taylor & Francis Ltd, Abingdon, 2017)

TY  - BOOK
AU  - Baroud, Afya A.
AU  - Mihajlović-Lalić, Ljiljana
AU  - Gligorijević, Nevenka
AU  - Aranđelović, Sandra
AU  - Stanković, Dalibor
AU  - Radulović, Siniša
AU  - Van Hecke, Kristof
AU  - Savić, Aleksandar
AU  - Grgurić-Šipka, Sanja
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3138
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Coordination Chemistry
T1  - Supplementary data for article:  Baroud, A. A.; Mihajlović-Lalić, L. E.; Gligorijević, N.; Aranđelović, S.; Stanković, D.; Radulović, S.; Van Hecke, K.; Savić, A.; Grgurić-Šipka, S. Ruthenium(II) Bipyridine Complexes: From Synthesis and Crystal Structures to Electrochemical and Cytotoxicity Investigation. Journal of Coordination Chemistry 2017, 70 (5), 831–847. https://doi.org/10.1080/00958972.2017.1282611
ER  - 
@book{
author = "Baroud, Afya A. and Mihajlović-Lalić, Ljiljana and Gligorijević, Nevenka and Aranđelović, Sandra and Stanković, Dalibor and Radulović, Siniša and Van Hecke, Kristof and Savić, Aleksandar and Grgurić-Šipka, Sanja",
year = "2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3138",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Coordination Chemistry",
title = "Supplementary data for article:  Baroud, A. A.; Mihajlović-Lalić, L. E.; Gligorijević, N.; Aranđelović, S.; Stanković, D.; Radulović, S.; Van Hecke, K.; Savić, A.; Grgurić-Šipka, S. Ruthenium(II) Bipyridine Complexes: From Synthesis and Crystal Structures to Electrochemical and Cytotoxicity Investigation. Journal of Coordination Chemistry 2017, 70 (5), 831–847. https://doi.org/10.1080/00958972.2017.1282611"
}
Baroud, A. A., Mihajlović-Lalić, L., Gligorijević, N., Aranđelović, S., Stanković, D., Radulović, S., Van Hecke, K., Savić, A.,& Grgurić-Šipka, S. (2017). Supplementary data for article:  Baroud, A. A.; Mihajlović-Lalić, L. E.; Gligorijević, N.; Aranđelović, S.; Stanković, D.; Radulović, S.; Van Hecke, K.; Savić, A.; Grgurić-Šipka, S. Ruthenium(II) Bipyridine Complexes: From Synthesis and Crystal Structures to Electrochemical and Cytotoxicity Investigation. Journal of Coordination Chemistry 2017, 70 (5), 831–847. https://doi.org/10.1080/00958972.2017.1282611.
Journal of Coordination Chemistry
Taylor & Francis Ltd, Abingdon..
Baroud AA, Mihajlović-Lalić L, Gligorijević N, Aranđelović S, Stanković D, Radulović S, Van Hecke K, Savić A, Grgurić-Šipka S. Supplementary data for article:  Baroud, A. A.; Mihajlović-Lalić, L. E.; Gligorijević, N.; Aranđelović, S.; Stanković, D.; Radulović, S.; Van Hecke, K.; Savić, A.; Grgurić-Šipka, S. Ruthenium(II) Bipyridine Complexes: From Synthesis and Crystal Structures to Electrochemical and Cytotoxicity Investigation. Journal of Coordination Chemistry 2017, 70 (5), 831–847. https://doi.org/10.1080/00958972.2017.1282611. Journal of Coordination Chemistry. 2017;
Baroud Afya A., Mihajlović-Lalić Ljiljana, Gligorijević Nevenka, Aranđelović Sandra, Stanković Dalibor, Radulović Siniša, Van Hecke Kristof, Savić Aleksandar, Grgurić-Šipka Sanja, "Supplementary data for article:  Baroud, A. A.; Mihajlović-Lalić, L. E.; Gligorijević, N.; Aranđelović, S.; Stanković, D.; Radulović, S.; Van Hecke, K.; Savić, A.; Grgurić-Šipka, S. Ruthenium(II) Bipyridine Complexes: From Synthesis and Crystal Structures to Electrochemical and Cytotoxicity Investigation. Journal of Coordination Chemistry 2017, 70 (5), 831–847. https://doi.org/10.1080/00958972.2017.1282611" Journal of Coordination Chemistry (2017)

Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study

Smiljanić, Katarina; Apostolović, Danijela; Trifunović, Snežana S.; Ognjenović, J.; Peruško, Marija; Mihajlović-Lalić, Ljiljana; Burazer, Lidija M.; van Hage, Marianne; Ćirković-Veličković, Tanja

(Wiley, Hoboken, 2017)

TY  - JOUR
AU  - Smiljanić, Katarina
AU  - Apostolović, Danijela
AU  - Trifunović, Snežana S.
AU  - Ognjenović, J.
AU  - Peruško, Marija
AU  - Mihajlović-Lalić, Ljiljana
AU  - Burazer, Lidija M.
AU  - van Hage, Marianne
AU  - Ćirković-Veličković, Tanja
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3126
AB  - Background Short ragweed (Ambrosia artemisiifolia) allergies affect more than 36 million people annually. Ragweed pollen grains release subpollen particles (SPP) of respirable size upon hydration or a change in air electrical conditions. The aim of this study was to characterize the proteomes and allergomes of short ragweed SPP and total pollen protein extract (TOT), and compare their effects with those of standard aqueous pollen protein extract (APE) using sera from short ragweed pollen-sensitized patients. Methods Quantitative 2D gel-based and shotgun proteomics, 1D and 2D immunoblotting, and quantitative ELISA were applied. Novel SPP extraction and preparation protocols enabled appropriate sample preparation and further downstream analysis by quantitative proteomics. Results The SPP fraction contained the highest proportion (94%) of the allergome, with the largest quantities of the minor Amb a 4 and major Amb a 1 allergens, and as unique, NADH dehydrogenases. APE was the richest in Amb a 6, Amb a 5 and Amb a 3, and TOT fraction was the richest in the Amb a 8 allergens (89% and 83% of allergome, respectively). Allergenic potency correlated well among the three fractions tested, with 1D immunoblots demonstrating a slight predominance of IgE reactivity to SPP compared to TOT and APE. However, the strongest IgE binding in ELISA was noted against APE. New allergenic candidates, phosphoglycerate mutase and phosphoglucomutase, were identified in all the three pollen fractions. Enolase, UTP-glucose-1-phosphate uridylyltransferase and polygalacturonase were observed in SPP and TOT fractions as novel allergens of the short ragweed pollen, as previously described. Conclusion and Clinical Relevance We demonstrated that the complete major (Amb a 1 and 11) and almost all minor (Amb a 3, 4, 5, 6, 8 and 9) short ragweed pollen allergen repertoire as well as NADH oxidases are present in SPP, highlighting an important role for SPP in allergic sensitization to short ragweed.
PB  - Wiley, Hoboken
T2  - Clinical and Experimental Allergy
T1  - Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study
VL  - 47
IS  - 6
SP  - 815
EP  - 828
DO  - 10.1111/cea.12874
ER  - 
@article{
author = "Smiljanić, Katarina and Apostolović, Danijela and Trifunović, Snežana S. and Ognjenović, J. and Peruško, Marija and Mihajlović-Lalić, Ljiljana and Burazer, Lidija M. and van Hage, Marianne and Ćirković-Veličković, Tanja",
year = "2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3126",
abstract = "Background Short ragweed (Ambrosia artemisiifolia) allergies affect more than 36 million people annually. Ragweed pollen grains release subpollen particles (SPP) of respirable size upon hydration or a change in air electrical conditions. The aim of this study was to characterize the proteomes and allergomes of short ragweed SPP and total pollen protein extract (TOT), and compare their effects with those of standard aqueous pollen protein extract (APE) using sera from short ragweed pollen-sensitized patients. Methods Quantitative 2D gel-based and shotgun proteomics, 1D and 2D immunoblotting, and quantitative ELISA were applied. Novel SPP extraction and preparation protocols enabled appropriate sample preparation and further downstream analysis by quantitative proteomics. Results The SPP fraction contained the highest proportion (94%) of the allergome, with the largest quantities of the minor Amb a 4 and major Amb a 1 allergens, and as unique, NADH dehydrogenases. APE was the richest in Amb a 6, Amb a 5 and Amb a 3, and TOT fraction was the richest in the Amb a 8 allergens (89% and 83% of allergome, respectively). Allergenic potency correlated well among the three fractions tested, with 1D immunoblots demonstrating a slight predominance of IgE reactivity to SPP compared to TOT and APE. However, the strongest IgE binding in ELISA was noted against APE. New allergenic candidates, phosphoglycerate mutase and phosphoglucomutase, were identified in all the three pollen fractions. Enolase, UTP-glucose-1-phosphate uridylyltransferase and polygalacturonase were observed in SPP and TOT fractions as novel allergens of the short ragweed pollen, as previously described. Conclusion and Clinical Relevance We demonstrated that the complete major (Amb a 1 and 11) and almost all minor (Amb a 3, 4, 5, 6, 8 and 9) short ragweed pollen allergen repertoire as well as NADH oxidases are present in SPP, highlighting an important role for SPP in allergic sensitization to short ragweed.",
publisher = "Wiley, Hoboken",
journal = "Clinical and Experimental Allergy",
title = "Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study",
volume = "47",
number = "6",
pages = "815-828",
doi = "10.1111/cea.12874"
}
Smiljanić, K., Apostolović, D., Trifunović, S. S., Ognjenović, J., Peruško, M., Mihajlović-Lalić, L., Burazer, L. M., van Hage, M.,& Ćirković-Veličković, T. (2017). Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study.
Clinical and Experimental Allergy
Wiley, Hoboken., 47(6), 815-828.
https://doi.org/10.1111/cea.12874
Smiljanić K, Apostolović D, Trifunović SS, Ognjenović J, Peruško M, Mihajlović-Lalić L, Burazer LM, van Hage M, Ćirković-Veličković T. Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study. Clinical and Experimental Allergy. 2017;47(6):815-828
Smiljanić Katarina, Apostolović Danijela, Trifunović Snežana S., Ognjenović J., Peruško Marija, Mihajlović-Lalić Ljiljana, Burazer Lidija M., van Hage Marianne, Ćirković-Veličković Tanja, "Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study" Clinical and Experimental Allergy, 47, no. 6 (2017):815-828,
https://doi.org/10.1111/cea.12874 .
2
14
12
14

Supplementary data for article: Smiljanic, K.; Apostolovic, D.; Trifunovic, S.; Ognjenovic, J.; Perusko, M.; Mihajlovic, L.; Burazer, L.; van Hage, M.; Cirkovic Velickovic, T. Subpollen Particles Are Rich Carriers of Major Short Ragweed Allergens and NADH Dehydrogenases: Quantitative Proteomic and Allergomic Study. Clinical and Experimental Allergy 2017, 47 (6), 815–828. https://doi.org/10.1111/cea.12874

Smiljanić, Katarina; Apostolović, Danijela; Trifunović, Snežana S.; Ognjenović, J.; Peruško, Marija; Mihajlović-Lalić, Ljiljana; Burazer, Lidija M.; van Hage, Marianne; Ćirković-Veličković, Tanja

(Wiley, Hoboken, 2017)

TY  - BOOK
AU  - Smiljanić, Katarina
AU  - Apostolović, Danijela
AU  - Trifunović, Snežana S.
AU  - Ognjenović, J.
AU  - Peruško, Marija
AU  - Mihajlović-Lalić, Ljiljana
AU  - Burazer, Lidija M.
AU  - van Hage, Marianne
AU  - Ćirković-Veličković, Tanja
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3127
PB  - Wiley, Hoboken
T2  - Clinical and Experimental Allergy
T1  - Supplementary data for article:            Smiljanic, K.; Apostolovic, D.; Trifunovic, S.; Ognjenovic, J.; Perusko, M.; Mihajlovic, L.; Burazer, L.; van Hage, M.; Cirkovic Velickovic, T. Subpollen Particles Are Rich Carriers of Major Short Ragweed Allergens and NADH Dehydrogenases: Quantitative Proteomic and Allergomic Study. Clinical and Experimental Allergy 2017, 47 (6), 815–828. https://doi.org/10.1111/cea.12874
ER  - 
@book{
author = "Smiljanić, Katarina and Apostolović, Danijela and Trifunović, Snežana S. and Ognjenović, J. and Peruško, Marija and Mihajlović-Lalić, Ljiljana and Burazer, Lidija M. and van Hage, Marianne and Ćirković-Veličković, Tanja",
year = "2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3127",
publisher = "Wiley, Hoboken",
journal = "Clinical and Experimental Allergy",
title = "Supplementary data for article:            Smiljanic, K.; Apostolovic, D.; Trifunovic, S.; Ognjenovic, J.; Perusko, M.; Mihajlovic, L.; Burazer, L.; van Hage, M.; Cirkovic Velickovic, T. Subpollen Particles Are Rich Carriers of Major Short Ragweed Allergens and NADH Dehydrogenases: Quantitative Proteomic and Allergomic Study. Clinical and Experimental Allergy 2017, 47 (6), 815–828. https://doi.org/10.1111/cea.12874"
}
Smiljanić, K., Apostolović, D., Trifunović, S. S., Ognjenović, J., Peruško, M., Mihajlović-Lalić, L., Burazer, L. M., van Hage, M.,& Ćirković-Veličković, T. (2017). Supplementary data for article:            Smiljanic, K.; Apostolovic, D.; Trifunovic, S.; Ognjenovic, J.; Perusko, M.; Mihajlovic, L.; Burazer, L.; van Hage, M.; Cirkovic Velickovic, T. Subpollen Particles Are Rich Carriers of Major Short Ragweed Allergens and NADH Dehydrogenases: Quantitative Proteomic and Allergomic Study. Clinical and Experimental Allergy 2017, 47 (6), 815–828. https://doi.org/10.1111/cea.12874.
Clinical and Experimental Allergy
Wiley, Hoboken..
Smiljanić K, Apostolović D, Trifunović SS, Ognjenović J, Peruško M, Mihajlović-Lalić L, Burazer LM, van Hage M, Ćirković-Veličković T. Supplementary data for article:            Smiljanic, K.; Apostolovic, D.; Trifunovic, S.; Ognjenovic, J.; Perusko, M.; Mihajlovic, L.; Burazer, L.; van Hage, M.; Cirkovic Velickovic, T. Subpollen Particles Are Rich Carriers of Major Short Ragweed Allergens and NADH Dehydrogenases: Quantitative Proteomic and Allergomic Study. Clinical and Experimental Allergy 2017, 47 (6), 815–828. https://doi.org/10.1111/cea.12874. Clinical and Experimental Allergy. 2017;
Smiljanić Katarina, Apostolović Danijela, Trifunović Snežana S., Ognjenović J., Peruško Marija, Mihajlović-Lalić Ljiljana, Burazer Lidija M., van Hage Marianne, Ćirković-Veličković Tanja, "Supplementary data for article:            Smiljanic, K.; Apostolovic, D.; Trifunovic, S.; Ognjenovic, J.; Perusko, M.; Mihajlovic, L.; Burazer, L.; van Hage, M.; Cirkovic Velickovic, T. Subpollen Particles Are Rich Carriers of Major Short Ragweed Allergens and NADH Dehydrogenases: Quantitative Proteomic and Allergomic Study. Clinical and Experimental Allergy 2017, 47 (6), 815–828. https://doi.org/10.1111/cea.12874" Clinical and Experimental Allergy (2017)

Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study

Smiljanić, Katarina; Apostolović, Danijela; Trifunović, Snežana S.; Ognjenović, J.; Peruško, Marija; Mihajlović-Lalić, Ljiljana; Burazer, Lidija M.; van Hage, Marianne; Ćirković-Veličković, Tanja

(Wiley, Hoboken, 2017)

TY  - JOUR
AU  - Smiljanić, Katarina
AU  - Apostolović, Danijela
AU  - Trifunović, Snežana S.
AU  - Ognjenović, J.
AU  - Peruško, Marija
AU  - Mihajlović-Lalić, Ljiljana
AU  - Burazer, Lidija M.
AU  - van Hage, Marianne
AU  - Ćirković-Veličković, Tanja
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2468
AB  - Background Short ragweed (Ambrosia artemisiifolia) allergies affect more than 36 million people annually. Ragweed pollen grains release subpollen particles (SPP) of respirable size upon hydration or a change in air electrical conditions. The aim of this study was to characterize the proteomes and allergomes of short ragweed SPP and total pollen protein extract (TOT), and compare their effects with those of standard aqueous pollen protein extract (APE) using sera from short ragweed pollen-sensitized patients. Methods Quantitative 2D gel-based and shotgun proteomics, 1D and 2D immunoblotting, and quantitative ELISA were applied. Novel SPP extraction and preparation protocols enabled appropriate sample preparation and further downstream analysis by quantitative proteomics. Results The SPP fraction contained the highest proportion (94%) of the allergome, with the largest quantities of the minor Amb a 4 and major Amb a 1 allergens, and as unique, NADH dehydrogenases. APE was the richest in Amb a 6, Amb a 5 and Amb a 3, and TOT fraction was the richest in the Amb a 8 allergens (89% and 83% of allergome, respectively). Allergenic potency correlated well among the three fractions tested, with 1D immunoblots demonstrating a slight predominance of IgE reactivity to SPP compared to TOT and APE. However, the strongest IgE binding in ELISA was noted against APE. New allergenic candidates, phosphoglycerate mutase and phosphoglucomutase, were identified in all the three pollen fractions. Enolase, UTP-glucose-1-phosphate uridylyltransferase and polygalacturonase were observed in SPP and TOT fractions as novel allergens of the short ragweed pollen, as previously described. Conclusion and Clinical Relevance We demonstrated that the complete major (Amb a 1 and 11) and almost all minor (Amb a 3, 4, 5, 6, 8 and 9) short ragweed pollen allergen repertoire as well as NADH oxidases are present in SPP, highlighting an important role for SPP in allergic sensitization to short ragweed.
PB  - Wiley, Hoboken
T2  - Clinical and Experimental Allergy
T1  - Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study
VL  - 47
IS  - 6
SP  - 815
EP  - 828
DO  - 10.1111/cea.12874
ER  - 
@article{
author = "Smiljanić, Katarina and Apostolović, Danijela and Trifunović, Snežana S. and Ognjenović, J. and Peruško, Marija and Mihajlović-Lalić, Ljiljana and Burazer, Lidija M. and van Hage, Marianne and Ćirković-Veličković, Tanja",
year = "2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2468",
abstract = "Background Short ragweed (Ambrosia artemisiifolia) allergies affect more than 36 million people annually. Ragweed pollen grains release subpollen particles (SPP) of respirable size upon hydration or a change in air electrical conditions. The aim of this study was to characterize the proteomes and allergomes of short ragweed SPP and total pollen protein extract (TOT), and compare their effects with those of standard aqueous pollen protein extract (APE) using sera from short ragweed pollen-sensitized patients. Methods Quantitative 2D gel-based and shotgun proteomics, 1D and 2D immunoblotting, and quantitative ELISA were applied. Novel SPP extraction and preparation protocols enabled appropriate sample preparation and further downstream analysis by quantitative proteomics. Results The SPP fraction contained the highest proportion (94%) of the allergome, with the largest quantities of the minor Amb a 4 and major Amb a 1 allergens, and as unique, NADH dehydrogenases. APE was the richest in Amb a 6, Amb a 5 and Amb a 3, and TOT fraction was the richest in the Amb a 8 allergens (89% and 83% of allergome, respectively). Allergenic potency correlated well among the three fractions tested, with 1D immunoblots demonstrating a slight predominance of IgE reactivity to SPP compared to TOT and APE. However, the strongest IgE binding in ELISA was noted against APE. New allergenic candidates, phosphoglycerate mutase and phosphoglucomutase, were identified in all the three pollen fractions. Enolase, UTP-glucose-1-phosphate uridylyltransferase and polygalacturonase were observed in SPP and TOT fractions as novel allergens of the short ragweed pollen, as previously described. Conclusion and Clinical Relevance We demonstrated that the complete major (Amb a 1 and 11) and almost all minor (Amb a 3, 4, 5, 6, 8 and 9) short ragweed pollen allergen repertoire as well as NADH oxidases are present in SPP, highlighting an important role for SPP in allergic sensitization to short ragweed.",
publisher = "Wiley, Hoboken",
journal = "Clinical and Experimental Allergy",
title = "Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study",
volume = "47",
number = "6",
pages = "815-828",
doi = "10.1111/cea.12874"
}
Smiljanić, K., Apostolović, D., Trifunović, S. S., Ognjenović, J., Peruško, M., Mihajlović-Lalić, L., Burazer, L. M., van Hage, M.,& Ćirković-Veličković, T. (2017). Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study.
Clinical and Experimental Allergy
Wiley, Hoboken., 47(6), 815-828.
https://doi.org/10.1111/cea.12874
Smiljanić K, Apostolović D, Trifunović SS, Ognjenović J, Peruško M, Mihajlović-Lalić L, Burazer LM, van Hage M, Ćirković-Veličković T. Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study. Clinical and Experimental Allergy. 2017;47(6):815-828
Smiljanić Katarina, Apostolović Danijela, Trifunović Snežana S., Ognjenović J., Peruško Marija, Mihajlović-Lalić Ljiljana, Burazer Lidija M., van Hage Marianne, Ćirković-Veličković Tanja, "Subpollen particles are rich carriers of major short ragweed allergens and NADH dehydrogenases: quantitative proteomic and allergomic study" Clinical and Experimental Allergy, 47, no. 6 (2017):815-828,
https://doi.org/10.1111/cea.12874 .
2
14
12
14

Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation

Baroud, Afya A.; Mihajlović-Lalić, Ljiljana; Gligorijević, Nevenka; Aranđelović, Sandra; Stanković, Dalibor; Radulović, Siniša; Van Hecke, Kristof; Savić, Aleksandar; Grgurić-Šipka, Sanja

(Taylor & Francis Ltd, Abingdon, 2017)

TY  - JOUR
AU  - Baroud, Afya A.
AU  - Mihajlović-Lalić, Ljiljana
AU  - Gligorijević, Nevenka
AU  - Aranđelović, Sandra
AU  - Stanković, Dalibor
AU  - Radulović, Siniša
AU  - Van Hecke, Kristof
AU  - Savić, Aleksandar
AU  - Grgurić-Šipka, Sanja
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2423
AB  - Complexes 1-4, [Ru(L)(bpy)(2)]PF6, where bpy=2,2-bipyridine; HL=3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) and 6-bromopyridine-2-carboxylic acid (HL4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 +/- 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200M. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction. [GRAPHICS]
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Coordination Chemistry
T1  - Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation
VL  - 70
IS  - 5
SP  - 831
EP  - 847
DO  - 10.1080/00958972.2017.1282611
ER  - 
@article{
author = "Baroud, Afya A. and Mihajlović-Lalić, Ljiljana and Gligorijević, Nevenka and Aranđelović, Sandra and Stanković, Dalibor and Radulović, Siniša and Van Hecke, Kristof and Savić, Aleksandar and Grgurić-Šipka, Sanja",
year = "2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2423",
abstract = "Complexes 1-4, [Ru(L)(bpy)(2)]PF6, where bpy=2,2-bipyridine; HL=3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) and 6-bromopyridine-2-carboxylic acid (HL4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 +/- 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200M. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction. [GRAPHICS]",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Coordination Chemistry",
title = "Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation",
volume = "70",
number = "5",
pages = "831-847",
doi = "10.1080/00958972.2017.1282611"
}
Baroud, A. A., Mihajlović-Lalić, L., Gligorijević, N., Aranđelović, S., Stanković, D., Radulović, S., Van Hecke, K., Savić, A.,& Grgurić-Šipka, S. (2017). Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation.
Journal of Coordination Chemistry
Taylor & Francis Ltd, Abingdon., 70(5), 831-847.
https://doi.org/10.1080/00958972.2017.1282611
Baroud AA, Mihajlović-Lalić L, Gligorijević N, Aranđelović S, Stanković D, Radulović S, Van Hecke K, Savić A, Grgurić-Šipka S. Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation. Journal of Coordination Chemistry. 2017;70(5):831-847
Baroud Afya A., Mihajlović-Lalić Ljiljana, Gligorijević Nevenka, Aranđelović Sandra, Stanković Dalibor, Radulović Siniša, Van Hecke Kristof, Savić Aleksandar, Grgurić-Šipka Sanja, "Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation" Journal of Coordination Chemistry, 70, no. 5 (2017):831-847,
https://doi.org/10.1080/00958972.2017.1282611 .
7
7
7

New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity

Baroud, Afya A.; Mihajlović-Lalić, Ljiljana; Stanković, Dalibor; Kajzerberger, Marijana; Van Hecke, Kristof; Grgurić-Šipka, Sanja; Savić, Aleksandar

(Serbian Chemical Soc, Belgrade, 2017)

TY  - JOUR
AU  - Baroud, Afya A.
AU  - Mihajlović-Lalić, Ljiljana
AU  - Stanković, Dalibor
AU  - Kajzerberger, Marijana
AU  - Van Hecke, Kristof
AU  - Grgurić-Šipka, Sanja
AU  - Savić, Aleksandar
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2457
AB  - A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were  gt 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity
VL  - 82
IS  - 3
SP  - 267
EP  - 275
DO  - 10.2298/JSC170109025B
ER  - 
@article{
author = "Baroud, Afya A. and Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Kajzerberger, Marijana and Van Hecke, Kristof and Grgurić-Šipka, Sanja and Savić, Aleksandar",
year = "2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2457",
abstract = "A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were  gt 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity",
volume = "82",
number = "3",
pages = "267-275",
doi = "10.2298/JSC170109025B"
}
Baroud, A. A., Mihajlović-Lalić, L., Stanković, D., Kajzerberger, M., Van Hecke, K., Grgurić-Šipka, S.,& Savić, A. (2017). New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity.
Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 82(3), 267-275.
https://doi.org/10.2298/JSC170109025B
Baroud AA, Mihajlović-Lalić L, Stanković D, Kajzerberger M, Van Hecke K, Grgurić-Šipka S, Savić A. New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity. Journal of the Serbian Chemical Society. 2017;82(3):267-275
Baroud Afya A., Mihajlović-Lalić Ljiljana, Stanković Dalibor, Kajzerberger Marijana, Van Hecke Kristof, Grgurić-Šipka Sanja, Savić Aleksandar, "New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity" Journal of the Serbian Chemical Society, 82, no. 3 (2017):267-275,
https://doi.org/10.2298/JSC170109025B .
1
2
2
2

Supplementary material for the article: Mihajlović-Lalić, L. E.; Damjanović, L.; Šumar-Ristović, M.; Savić, A.; Sabo, T. J.; Dondur, V.; Grgurić-Šipka, S. Cytotoxic Pt(IV) and Ru(II) Complexes Containing a Biologically Relevant Edda-Type Ligand: A Comparative Study of Their Thermal Properties. Journal of the Serbian Chemical Society 2016, 81 (8), 897–905. https://doi.org/10.2298/JSC160320059M

Mihajlović-Lalić, Ljiljana; Damjanovic, Ljiljana; Šumar-Ristović, Maja; Savić, Aleksandar; Sabo, Tibor; Dondur, Vera; Grgurić-Šipka, Sanja

(Serbian Chemical Soc, Belgrade, 2016)

TY  - BOOK
AU  - Mihajlović-Lalić, Ljiljana
AU  - Damjanovic, Ljiljana
AU  - Šumar-Ristović, Maja
AU  - Savić, Aleksandar
AU  - Sabo, Tibor
AU  - Dondur, Vera
AU  - Grgurić-Šipka, Sanja
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3434
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Supplementary material for the article: Mihajlović-Lalić, L. E.; Damjanović, L.; Šumar-Ristović, M.; Savić, A.; Sabo, T. J.; Dondur, V.; Grgurić-Šipka, S. Cytotoxic Pt(IV) and Ru(II) Complexes Containing a Biologically Relevant Edda-Type Ligand: A Comparative Study of Their Thermal Properties. Journal of the Serbian Chemical Society 2016, 81 (8), 897–905. https://doi.org/10.2298/JSC160320059M
ER  - 
@book{
author = "Mihajlović-Lalić, Ljiljana and Damjanovic, Ljiljana and Šumar-Ristović, Maja and Savić, Aleksandar and Sabo, Tibor and Dondur, Vera and Grgurić-Šipka, Sanja",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3434",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Supplementary material for the article: Mihajlović-Lalić, L. E.; Damjanović, L.; Šumar-Ristović, M.; Savić, A.; Sabo, T. J.; Dondur, V.; Grgurić-Šipka, S. Cytotoxic Pt(IV) and Ru(II) Complexes Containing a Biologically Relevant Edda-Type Ligand: A Comparative Study of Their Thermal Properties. Journal of the Serbian Chemical Society 2016, 81 (8), 897–905. https://doi.org/10.2298/JSC160320059M"
}
Mihajlović-Lalić, L., Damjanovic, L., Šumar-Ristović, M., Savić, A., Sabo, T., Dondur, V.,& Grgurić-Šipka, S. (2016). Supplementary material for the article: Mihajlović-Lalić, L. E.; Damjanović, L.; Šumar-Ristović, M.; Savić, A.; Sabo, T. J.; Dondur, V.; Grgurić-Šipka, S. Cytotoxic Pt(IV) and Ru(II) Complexes Containing a Biologically Relevant Edda-Type Ligand: A Comparative Study of Their Thermal Properties. Journal of the Serbian Chemical Society 2016, 81 (8), 897–905. https://doi.org/10.2298/JSC160320059M.
Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade..
Mihajlović-Lalić L, Damjanovic L, Šumar-Ristović M, Savić A, Sabo T, Dondur V, Grgurić-Šipka S. Supplementary material for the article: Mihajlović-Lalić, L. E.; Damjanović, L.; Šumar-Ristović, M.; Savić, A.; Sabo, T. J.; Dondur, V.; Grgurić-Šipka, S. Cytotoxic Pt(IV) and Ru(II) Complexes Containing a Biologically Relevant Edda-Type Ligand: A Comparative Study of Their Thermal Properties. Journal of the Serbian Chemical Society 2016, 81 (8), 897–905. https://doi.org/10.2298/JSC160320059M. Journal of the Serbian Chemical Society. 2016;
Mihajlović-Lalić Ljiljana, Damjanovic Ljiljana, Šumar-Ristović Maja, Savić Aleksandar, Sabo Tibor, Dondur Vera, Grgurić-Šipka Sanja, "Supplementary material for the article: Mihajlović-Lalić, L. E.; Damjanović, L.; Šumar-Ristović, M.; Savić, A.; Sabo, T. J.; Dondur, V.; Grgurić-Šipka, S. Cytotoxic Pt(IV) and Ru(II) Complexes Containing a Biologically Relevant Edda-Type Ligand: A Comparative Study of Their Thermal Properties. Journal of the Serbian Chemical Society 2016, 81 (8), 897–905. https://doi.org/10.2298/JSC160320059M" Journal of the Serbian Chemical Society (2016)

Supplementary data for the article: Mihajlovic, L.; Radosavljevic, J.; Nordlund, E.; Krstic, M.; Bohn, T.; Smit, J.; Buchert, J.; Cirkovic Velickovic, T. Peanut Protein Structure, Polyphenol Content and Immune Response to Peanut Proteins: In Vivo Are Modulated by Laccase. Food and Function 2016, 7 (5), 2357–2366. https://doi.org/10.1039/c5fo01325a

Mihajlović-Lalić, Ljiljana; Radosavljević, Jelena; Nordlund, Emilia; Krstić-Ristivojević, Maja; Bohn, Torsten; Smit, Joost; Buchert, Johanna; Ćirković-Veličković, Tanja

(Royal Soc Chemistry, Cambridge, 2016)

TY  - BOOK
AU  - Mihajlović-Lalić, Ljiljana
AU  - Radosavljević, Jelena
AU  - Nordlund, Emilia
AU  - Krstić-Ristivojević, Maja
AU  - Bohn, Torsten
AU  - Smit, Joost
AU  - Buchert, Johanna
AU  - Ćirković-Veličković, Tanja
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3591
PB  - Royal Soc Chemistry, Cambridge
T2  - Food and Function
T1  - Supplementary data for the article: Mihajlovic, L.; Radosavljevic, J.; Nordlund, E.; Krstic, M.; Bohn, T.; Smit, J.; Buchert, J.; Cirkovic Velickovic, T. Peanut Protein Structure, Polyphenol Content and Immune Response to Peanut Proteins: In Vivo Are Modulated by Laccase. Food and Function 2016, 7 (5), 2357–2366. https://doi.org/10.1039/c5fo01325a
ER  - 
@book{
author = "Mihajlović-Lalić, Ljiljana and Radosavljević, Jelena and Nordlund, Emilia and Krstić-Ristivojević, Maja and Bohn, Torsten and Smit, Joost and Buchert, Johanna and Ćirković-Veličković, Tanja",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3591",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Food and Function",
title = "Supplementary data for the article: Mihajlovic, L.; Radosavljevic, J.; Nordlund, E.; Krstic, M.; Bohn, T.; Smit, J.; Buchert, J.; Cirkovic Velickovic, T. Peanut Protein Structure, Polyphenol Content and Immune Response to Peanut Proteins: In Vivo Are Modulated by Laccase. Food and Function 2016, 7 (5), 2357–2366. https://doi.org/10.1039/c5fo01325a"
}
Mihajlović-Lalić, L., Radosavljević, J., Nordlund, E., Krstić-Ristivojević, M., Bohn, T., Smit, J., Buchert, J.,& Ćirković-Veličković, T. (2016). Supplementary data for the article: Mihajlovic, L.; Radosavljevic, J.; Nordlund, E.; Krstic, M.; Bohn, T.; Smit, J.; Buchert, J.; Cirkovic Velickovic, T. Peanut Protein Structure, Polyphenol Content and Immune Response to Peanut Proteins: In Vivo Are Modulated by Laccase. Food and Function 2016, 7 (5), 2357–2366. https://doi.org/10.1039/c5fo01325a.
Food and Function
Royal Soc Chemistry, Cambridge..
Mihajlović-Lalić L, Radosavljević J, Nordlund E, Krstić-Ristivojević M, Bohn T, Smit J, Buchert J, Ćirković-Veličković T. Supplementary data for the article: Mihajlovic, L.; Radosavljevic, J.; Nordlund, E.; Krstic, M.; Bohn, T.; Smit, J.; Buchert, J.; Cirkovic Velickovic, T. Peanut Protein Structure, Polyphenol Content and Immune Response to Peanut Proteins: In Vivo Are Modulated by Laccase. Food and Function 2016, 7 (5), 2357–2366. https://doi.org/10.1039/c5fo01325a. Food and Function. 2016;
Mihajlović-Lalić Ljiljana, Radosavljević Jelena, Nordlund Emilia, Krstić-Ristivojević Maja, Bohn Torsten, Smit Joost, Buchert Johanna, Ćirković-Veličković Tanja, "Supplementary data for the article: Mihajlovic, L.; Radosavljevic, J.; Nordlund, E.; Krstic, M.; Bohn, T.; Smit, J.; Buchert, J.; Cirkovic Velickovic, T. Peanut Protein Structure, Polyphenol Content and Immune Response to Peanut Proteins: In Vivo Are Modulated by Laccase. Food and Function 2016, 7 (5), 2357–2366. https://doi.org/10.1039/c5fo01325a" Food and Function (2016)

Peanut protein structure, polyphenol content and immune response to peanut proteins in vivo are modulated by laccase

Mihajlović-Lalić, Ljiljana; Radosavljević, Jelena; Nordlund, Emilia; Krstić-Ristivojević, Maja; Bohn, Torsten; Smit, Joost; Buchert, Johanna; Ćirković-Veličković, Tanja

(Royal Soc Chemistry, Cambridge, 2016)

TY  - JOUR
AU  - Mihajlović-Lalić, Ljiljana
AU  - Radosavljević, Jelena
AU  - Nordlund, Emilia
AU  - Krstić-Ristivojević, Maja
AU  - Bohn, Torsten
AU  - Smit, Joost
AU  - Buchert, Johanna
AU  - Ćirković-Veličković, Tanja
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2254
AB  - Food texture can be improved by enzyme-mediated covalent cross-linking of different food components, such as proteins and carbohydrates. Cross-linking changes the biological and immunological properties of proteins and may change the sensitizing potential of food allergens. In this study we applied a microbial polyphenol oxidase, laccase, to cross-link peanut proteins. The size and morphology of the obtained cross-linked proteins were analyzed by electrophoresis and electron microscopy. Structural changes in proteins were analyzed by CD spectroscopy and by using specific antibodies to major peanut allergens. The bioavailability of peanut proteins was analyzed using a Caco-2 epithelial cell model. The in vivo sensitizing potential of laccase-treated peanut proteins was analyzed using a mouse model of food allergy. Finally, peanut polyphenols were analyzed by UHPLC-MS/MS, before and after the enzymatic reaction with laccase. Laccase treatment of peanut proteins yielded a covalently cross-linked material, with the modified tertiary structure of peanut proteins, improved bioavailability of Ara h 2 (by 70 fold, p  lt  0.05) and modulated allergic immune response in vivo. The modulation of the immune response was related to the increased production of IgG2a antibodies 11 fold (p  lt  0.05) and reduced IL-13 secretion in in vitro cultured splenocytes 7 fold (p  lt  0.05). Analysis of the peanut polyphenol content and profile by HPLC-MS/MS revealed that laccase treatment depleted the peanut extract of polyphenol compounds leaving mostly isorhamnetin derivatives and procyanidin dimer B-type in detectable amounts. Treatment of complex food extracts rich in polyphenols with laccase results in both protein cross-linking and modification of polyphenol compounds. These extensively cross-linked proteins have unchanged potency to induce allergic sensitization in vivo, but certain immunomodulatory changes were observed.
PB  - Royal Soc Chemistry, Cambridge
T2  - Food and Function
T1  - Peanut protein structure, polyphenol content and immune response to peanut proteins in vivo are modulated by laccase
VL  - 7
IS  - 5
SP  - 2357
EP  - 2366
DO  - 10.1039/c5fo01325a
ER  - 
@article{
author = "Mihajlović-Lalić, Ljiljana and Radosavljević, Jelena and Nordlund, Emilia and Krstić-Ristivojević, Maja and Bohn, Torsten and Smit, Joost and Buchert, Johanna and Ćirković-Veličković, Tanja",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2254",
abstract = "Food texture can be improved by enzyme-mediated covalent cross-linking of different food components, such as proteins and carbohydrates. Cross-linking changes the biological and immunological properties of proteins and may change the sensitizing potential of food allergens. In this study we applied a microbial polyphenol oxidase, laccase, to cross-link peanut proteins. The size and morphology of the obtained cross-linked proteins were analyzed by electrophoresis and electron microscopy. Structural changes in proteins were analyzed by CD spectroscopy and by using specific antibodies to major peanut allergens. The bioavailability of peanut proteins was analyzed using a Caco-2 epithelial cell model. The in vivo sensitizing potential of laccase-treated peanut proteins was analyzed using a mouse model of food allergy. Finally, peanut polyphenols were analyzed by UHPLC-MS/MS, before and after the enzymatic reaction with laccase. Laccase treatment of peanut proteins yielded a covalently cross-linked material, with the modified tertiary structure of peanut proteins, improved bioavailability of Ara h 2 (by 70 fold, p  lt  0.05) and modulated allergic immune response in vivo. The modulation of the immune response was related to the increased production of IgG2a antibodies 11 fold (p  lt  0.05) and reduced IL-13 secretion in in vitro cultured splenocytes 7 fold (p  lt  0.05). Analysis of the peanut polyphenol content and profile by HPLC-MS/MS revealed that laccase treatment depleted the peanut extract of polyphenol compounds leaving mostly isorhamnetin derivatives and procyanidin dimer B-type in detectable amounts. Treatment of complex food extracts rich in polyphenols with laccase results in both protein cross-linking and modification of polyphenol compounds. These extensively cross-linked proteins have unchanged potency to induce allergic sensitization in vivo, but certain immunomodulatory changes were observed.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Food and Function",
title = "Peanut protein structure, polyphenol content and immune response to peanut proteins in vivo are modulated by laccase",
volume = "7",
number = "5",
pages = "2357-2366",
doi = "10.1039/c5fo01325a"
}
Mihajlović-Lalić, L., Radosavljević, J., Nordlund, E., Krstić-Ristivojević, M., Bohn, T., Smit, J., Buchert, J.,& Ćirković-Veličković, T. (2016). Peanut protein structure, polyphenol content and immune response to peanut proteins in vivo are modulated by laccase.
Food and Function
Royal Soc Chemistry, Cambridge., 7(5), 2357-2366.
https://doi.org/10.1039/c5fo01325a
Mihajlović-Lalić L, Radosavljević J, Nordlund E, Krstić-Ristivojević M, Bohn T, Smit J, Buchert J, Ćirković-Veličković T. Peanut protein structure, polyphenol content and immune response to peanut proteins in vivo are modulated by laccase. Food and Function. 2016;7(5):2357-2366
Mihajlović-Lalić Ljiljana, Radosavljević Jelena, Nordlund Emilia, Krstić-Ristivojević Maja, Bohn Torsten, Smit Joost, Buchert Johanna, Ćirković-Veličković Tanja, "Peanut protein structure, polyphenol content and immune response to peanut proteins in vivo are modulated by laccase" Food and Function, 7, no. 5 (2016):2357-2366,
https://doi.org/10.1039/c5fo01325a .
2
9
4
7

Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties

Mihajlović-Lalić, Ljiljana; Damjanovic, Ljiljana; Šumar-Ristović, Maja; Savić, Aleksandar; Sabo, Tibor; Dondur, Vera; Grgurić-Šipka, Sanja

(Serbian Chemical Soc, Belgrade, 2016)

TY  - JOUR
AU  - Mihajlović-Lalić, Ljiljana
AU  - Damjanovic, Ljiljana
AU  - Šumar-Ristović, Maja
AU  - Savić, Aleksandar
AU  - Sabo, Tibor
AU  - Dondur, Vera
AU  - Grgurić-Šipka, Sanja
PY  - 2016
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2325
AB  - The thermal behaviour of a Pt(IV) and a Ru(II) complex coordinated to dibutyl (S,S)-alpha,alpha'-(1,2-ethanediyldiimino)biscyclohexanepropanoate was investigated using thermogravimetry (TG) and differential scanning calorimetry (DSC). The study included an investigation of the thermal decomposition of these complexes in the temperature range of 30 to 590 degrees C and an evaluation of the activation energy for the first decomposition steps. For both metal complexes, broad DSC peaks indicated complex thermal transformation processes. The two-step decomposition of the Pt(IV) complex started at 175 and ended at about 418 degrees C, leaving elemental platinum as the final residue. On the other hand, the Ru(II) analogue decomposed in three stages. Thermal degradation was evident beginning at 144 degrees C and suggested the decomposition of a coordinated ligand as the dominant process. For this complex, the proposed final residue was RuO2. Kinetic parameters for the first decomposition step were obtained by means of the multi-heating rates method, in this case the Kissinger-Akahira-Sunose (KAS) method. The mean activation energy calculated for 0.2  lt  alpha  lt  0.8 were 122.0 kJ mol(-1) for the Pt(IV) and 118.9 kJ mol(-1) for the Ru(II) complex and decreased constantly, a characteristic of a multi-step process.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties
VL  - 81
IS  - 8
SP  - 897
EP  - 905
DO  - 10.2298/JSC160320059M
ER  - 
@article{
author = "Mihajlović-Lalić, Ljiljana and Damjanovic, Ljiljana and Šumar-Ristović, Maja and Savić, Aleksandar and Sabo, Tibor and Dondur, Vera and Grgurić-Šipka, Sanja",
year = "2016",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2325",
abstract = "The thermal behaviour of a Pt(IV) and a Ru(II) complex coordinated to dibutyl (S,S)-alpha,alpha'-(1,2-ethanediyldiimino)biscyclohexanepropanoate was investigated using thermogravimetry (TG) and differential scanning calorimetry (DSC). The study included an investigation of the thermal decomposition of these complexes in the temperature range of 30 to 590 degrees C and an evaluation of the activation energy for the first decomposition steps. For both metal complexes, broad DSC peaks indicated complex thermal transformation processes. The two-step decomposition of the Pt(IV) complex started at 175 and ended at about 418 degrees C, leaving elemental platinum as the final residue. On the other hand, the Ru(II) analogue decomposed in three stages. Thermal degradation was evident beginning at 144 degrees C and suggested the decomposition of a coordinated ligand as the dominant process. For this complex, the proposed final residue was RuO2. Kinetic parameters for the first decomposition step were obtained by means of the multi-heating rates method, in this case the Kissinger-Akahira-Sunose (KAS) method. The mean activation energy calculated for 0.2  lt  alpha  lt  0.8 were 122.0 kJ mol(-1) for the Pt(IV) and 118.9 kJ mol(-1) for the Ru(II) complex and decreased constantly, a characteristic of a multi-step process.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties",
volume = "81",
number = "8",
pages = "897-905",
doi = "10.2298/JSC160320059M"
}
Mihajlović-Lalić, L., Damjanovic, L., Šumar-Ristović, M., Savić, A., Sabo, T., Dondur, V.,& Grgurić-Šipka, S. (2016). Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties.
Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 81(8), 897-905.
https://doi.org/10.2298/JSC160320059M
Mihajlović-Lalić L, Damjanovic L, Šumar-Ristović M, Savić A, Sabo T, Dondur V, Grgurić-Šipka S. Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties. Journal of the Serbian Chemical Society. 2016;81(8):897-905
Mihajlović-Lalić Ljiljana, Damjanovic Ljiljana, Šumar-Ristović Maja, Savić Aleksandar, Sabo Tibor, Dondur Vera, Grgurić-Šipka Sanja, "Cytotoxic Pt(IV) and Ru(II) complexes containing a biologically relevant edda-type ligand: A comparative study of their thermal properties" Journal of the Serbian Chemical Society, 81, no. 8 (2016):897-905,
https://doi.org/10.2298/JSC160320059M .

Supplementary data for article: Peschel, L. M.; Holzer, C.; Mihajlovic-Lalic, L.; Belaj, F.; Mösch-Zanetti, N. C. Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes. European Journal of Inorganic Chemistry 2015, 2015 (9), 1569–1578. https://doi.org/10.1002/ejic.201403108

Peschel, Lydia M.; Holzer, Christof; Mihajlović-Lalić, Ljiljana; Belaj, Ferdinand; Moesch-Zanetti, Nadia C.

(Wiley-V C H Verlag Gmbh, Weinheim, 2015)

TY  - BOOK
AU  - Peschel, Lydia M.
AU  - Holzer, Christof
AU  - Mihajlović-Lalić, Ljiljana
AU  - Belaj, Ferdinand
AU  - Moesch-Zanetti, Nadia C.
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3361
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - European Journal of Inorganic Chemistry
T1  - Supplementary data for article: Peschel, L. M.; Holzer, C.; Mihajlovic-Lalic, L.; Belaj, F.; Mösch-Zanetti, N. C. Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes. European Journal of Inorganic Chemistry 2015, 2015 (9), 1569–1578. https://doi.org/10.1002/ejic.201403108
ER  - 
@book{
author = "Peschel, Lydia M. and Holzer, Christof and Mihajlović-Lalić, Ljiljana and Belaj, Ferdinand and Moesch-Zanetti, Nadia C.",
year = "2015",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3361",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "European Journal of Inorganic Chemistry",
title = "Supplementary data for article: Peschel, L. M.; Holzer, C.; Mihajlovic-Lalic, L.; Belaj, F.; Mösch-Zanetti, N. C. Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes. European Journal of Inorganic Chemistry 2015, 2015 (9), 1569–1578. https://doi.org/10.1002/ejic.201403108"
}
Peschel, L. M., Holzer, C., Mihajlović-Lalić, L., Belaj, F.,& Moesch-Zanetti, N. C. (2015). Supplementary data for article: Peschel, L. M.; Holzer, C.; Mihajlovic-Lalic, L.; Belaj, F.; Mösch-Zanetti, N. C. Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes. European Journal of Inorganic Chemistry 2015, 2015 (9), 1569–1578. https://doi.org/10.1002/ejic.201403108.
European Journal of Inorganic Chemistry
Wiley-V C H Verlag Gmbh, Weinheim..
Peschel LM, Holzer C, Mihajlović-Lalić L, Belaj F, Moesch-Zanetti NC. Supplementary data for article: Peschel, L. M.; Holzer, C.; Mihajlovic-Lalic, L.; Belaj, F.; Mösch-Zanetti, N. C. Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes. European Journal of Inorganic Chemistry 2015, 2015 (9), 1569–1578. https://doi.org/10.1002/ejic.201403108. European Journal of Inorganic Chemistry. 2015;
Peschel Lydia M., Holzer Christof, Mihajlović-Lalić Ljiljana, Belaj Ferdinand, Moesch-Zanetti Nadia C., "Supplementary data for article: Peschel, L. M.; Holzer, C.; Mihajlovic-Lalic, L.; Belaj, F.; Mösch-Zanetti, N. C. Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes. European Journal of Inorganic Chemistry 2015, 2015 (9), 1569–1578. https://doi.org/10.1002/ejic.201403108" European Journal of Inorganic Chemistry (2015)

Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes

Peschel, Lydia M.; Holzer, Christof; Mihajlović-Lalić, Ljiljana; Belaj, Ferdinand; Moesch-Zanetti, Nadia C.

(Wiley-V C H Verlag Gmbh, Weinheim, 2015)

TY  - JOUR
AU  - Peschel, Lydia M.
AU  - Holzer, Christof
AU  - Mihajlović-Lalić, Ljiljana
AU  - Belaj, Ferdinand
AU  - Moesch-Zanetti, Nadia C.
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1677
AB  - The synthesis, full characterization, and molecular structures of seven new coordination compounds that feature the 2-(4',4'-dimethyloxazolin-2'-yl)thiophenolate ligand (S-Phoz) with group 10 metals Ni, Pd, and Pt in the +II oxidation state are presented. The ML2 complexes [Pt(S-Phoz)(2)] (1a), [Pd(S-Phoz)(2)] (1b), and [Ni(S-Phoz)(2)] (2) were prepared starting from MCl2. Compound 1a was obtained isomerically pure in a trans arrangement, whereas its Pd analogue 1b exhibits a dynamic, solvent-dependent cis/trans equilibrium, and 2 adopts a tetrahedral arrangement. The reaction of LiS-Phoz with [cis-MCl2(PPh3)(2)] precursors resulted in full replacement of the PPh3 for M = Ni and in partial substitution for M = Pt, Pd to yield [Ni(S-Phoz)(2)] (2), [Pt(kappa(2)-S-Phoz)(kappa(1)-S-Phoz)-(PPh3)] (3a), and [Pd(kappa(2)-S-Phoz)(kappa(1)-S-Phoz)(PPh3)] (3b). The Pd compound 3b exhibits an interesting solvent-dependent equilibrium with 1b and PPh3 as demonstrated by H-1 and P-31 NMR spectroscopy. Compounds [{PdCl(S-Phoz)}(2)] (4) and [PdCl(S-Phoz)(PPh3)] (5) were synthesized from [PdCl2(NCMe)(2)]. Molecular structures of compounds trans-1a, trans-1b, 2, 3a, 3b, 4, and 5 were determined by singlecrystal X-ray diffraction studies. With the exception of the Ni complex 2, all compounds exhibit distorted square-planar geometries.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - European Journal of Inorganic Chemistry
T1  - Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes
IS  - 9
SP  - 1569
EP  - 1578
DO  - 10.1002/ejic.201403108
ER  - 
@article{
author = "Peschel, Lydia M. and Holzer, Christof and Mihajlović-Lalić, Ljiljana and Belaj, Ferdinand and Moesch-Zanetti, Nadia C.",
year = "2015",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1677",
abstract = "The synthesis, full characterization, and molecular structures of seven new coordination compounds that feature the 2-(4',4'-dimethyloxazolin-2'-yl)thiophenolate ligand (S-Phoz) with group 10 metals Ni, Pd, and Pt in the +II oxidation state are presented. The ML2 complexes [Pt(S-Phoz)(2)] (1a), [Pd(S-Phoz)(2)] (1b), and [Ni(S-Phoz)(2)] (2) were prepared starting from MCl2. Compound 1a was obtained isomerically pure in a trans arrangement, whereas its Pd analogue 1b exhibits a dynamic, solvent-dependent cis/trans equilibrium, and 2 adopts a tetrahedral arrangement. The reaction of LiS-Phoz with [cis-MCl2(PPh3)(2)] precursors resulted in full replacement of the PPh3 for M = Ni and in partial substitution for M = Pt, Pd to yield [Ni(S-Phoz)(2)] (2), [Pt(kappa(2)-S-Phoz)(kappa(1)-S-Phoz)-(PPh3)] (3a), and [Pd(kappa(2)-S-Phoz)(kappa(1)-S-Phoz)(PPh3)] (3b). The Pd compound 3b exhibits an interesting solvent-dependent equilibrium with 1b and PPh3 as demonstrated by H-1 and P-31 NMR spectroscopy. Compounds [{PdCl(S-Phoz)}(2)] (4) and [PdCl(S-Phoz)(PPh3)] (5) were synthesized from [PdCl2(NCMe)(2)]. Molecular structures of compounds trans-1a, trans-1b, 2, 3a, 3b, 4, and 5 were determined by singlecrystal X-ray diffraction studies. With the exception of the Ni complex 2, all compounds exhibit distorted square-planar geometries.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "European Journal of Inorganic Chemistry",
title = "Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes",
number = "9",
pages = "1569-1578",
doi = "10.1002/ejic.201403108"
}
Peschel, L. M., Holzer, C., Mihajlović-Lalić, L., Belaj, F.,& Moesch-Zanetti, N. C. (2015). Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes.
European Journal of Inorganic Chemistry
Wiley-V C H Verlag Gmbh, Weinheim.(9), 1569-1578.
https://doi.org/10.1002/ejic.201403108
Peschel LM, Holzer C, Mihajlović-Lalić L, Belaj F, Moesch-Zanetti NC. Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes. European Journal of Inorganic Chemistry. 2015;(9):1569-1578
Peschel Lydia M., Holzer Christof, Mihajlović-Lalić Ljiljana, Belaj Ferdinand, Moesch-Zanetti Nadia C., "Coordinative Flexibility of a Thiophenolate Oxazoline Ligand in Nickel(II), Palladium(II), and Platinum(II) Complexes" European Journal of Inorganic Chemistry, no. 9 (2015):1569-1578,
https://doi.org/10.1002/ejic.201403108 .
1
7
6
6

Sinteza, karakterizacija i redoks ponašanje Pt(II) i Pt(IV) kompleksa sa N,N i N,S ligandima

Mihajlović-Lalić, Ljiljana

(Универзитет у Београду, Хемијски факултет, 2014)

TY  - BOOK
AU  - Mihajlović-Lalić, Ljiljana
PY  - 2014
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=3252
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:11647/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=47613711
UR  - http://nardus.mpn.gov.rs/123456789/5900
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2685
AB  - U priloţenoj disertaciji su opisane sinteze, karakterizacija i oksido-redukciona svojstva dialkil estara N,N'-metilen-(S,S)-etilendiamin-N,N'-di-2-(3-cikloheksil) propanske kiseline, njima odgovarajućih kompleksa Pt(IV) kao i kompleksa Pt(II) sa tiofenolat-oksazolinskim ligandom.Spektroskopska karakterizacija sintetisanih jedinjenja je uraĊena standardnim metodama: infracrvenom i Ulj/Vid spektroskopijom, masenom spektrometrijom i NMR spektroskopijom (1D-1H i 13C; 2D-COSY, HSQC, HMBC tehnikama) dok je sastav jedinjenja potvrĊen elementalnom analizom. Struktura kompleksnih jedinjenja platine(II), [Pt(S-Phoz)2] i [Pt(η2S-Phoz)(η1S-Phoz)(PPh3)], odreĊena je i primenom rendgenske strukturne analize.Dialkil estri N,N'-metilen-(S,S)-etilendiamin-N,N'-di-2-(3-cikloheksil)propanske kiseline su dobijeni u reakciji reduktivnog metilovanja dialkil estara (S,S)-etilendiamin-N,N'-di-2-(3-cikloheksil)propanske kiseline triacetoborhidridom i formaldehidom u odgovarajućem stehiometrijskom odnosu. Sintetisani ligandi su reakcijom sa kalijum-heksahloridoplatinatom(IV) dali odgovarajuće komplekse platine(IV), oktaedarske geometrije sa N,N bidentatno vezanim ligandima. Dodatno je za ovu klasu jedinjenja ispitana citotoksiĉna aktivnost na razliĉitim ćelijskim linijama (A375, B16, CT26CL25, HCT116, PC3 i U251).Tiofenolat-oksazolinski ligand, Li(SPh-oz), je s obzirom na prisustvo dva razliĉita donorska atoma (azota i sumpora) pokazao razliĉite naĉine koordinovanja za platinski metalni centar. Prvobitno je reakcijom Li(SPh-oz) sa kalijum-tetrahloridoplatinatom(II) sintetisan [Pt(S-Phoz)2] kompleks deformisane kvadratno-planarne geometrije. Izolovani monokristalni produkt ovog jedinjenja je ukazao na S,S-trans raspored liganada oko metalnog centra. Zatim je u reakciji istog liganda sa cis-bis(trifenilfosfin)platina(II)-hloridom dobijen [Pt(η2S-Phoz)(η1S-Phoz)(PPh3)]...
AB  - An enclosed dissertation describes the synthesis, characterization and oxidoreductive properties of dialkyl esters of N,N′-methylene-(S,S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl)propanoic acid, their corresponding Pt(IV) complexes as well as Pt(II) complexes with thiophenolate-oxazoline ligand.Spectroscopic characterization of the synthesized compounds was performed by standard methods: infrared and UV/Vis spectroscopy, mass spectrometry and NMR spectroscopy (1D-1H and 13C and 2D-COSY, HSQC, HMBC techiques) while the compounds' content was confirmed by elemental analysis. The structures of Pt(II) species, [Pt(S-Phoz)2] and [Pt(η2S-Phoz)(η1S-Phoz)(PPh3)], were determined using X-ray structural analysis.Dialkyl esters of N,N′-methylene-(S,S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl)propanoic acid were obtained by reductive methylation of the parent compounds (dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl)propanoic acid) adding triacetoxyborohydride and formaldehyde in appropriate stoichiometric amounts. A reaction between synthesized ligands and potassium tetrachloroplatinate(II) afforded octahedral Pt(IV) complexes giving rise to N,N bidentate coordination. The cytotoxic activity toward various cancer cell lines (A375, B16, CT26CL25, HCT116, PC3 and U251) was additionally investigated for this class of compounds.Thiophenolate-oxazoline ligand, Li(SPh-oz) demonstrated different coordination modes due to the presence of two donor atoms (nitrogen and sulphur). Primarily, [Pt(S-Phoz)2] complex of distorted square planar geometry was obtained in a reaction of Li(SPh-oz) with potassium hexachloroplatinate(IV). The isolated monocrystal product of the specie indicated on S,S-trans arrangement of the ligands around the metal center. Nonetheless, a reaction between the identical ligand and cis-bis(triphenylphosphine)platinum(II) chloride afforded [Pt(η2S-Phoz)(η1S-Phoz)(PPh3)] complex for which 31P NMR spectroscopy and X-ray structural analysis confirmed...
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Sinteza, karakterizacija i redoks ponašanje Pt(II) i Pt(IV) kompleksa sa N,N i N,S ligandima
T1  - Synthesis, Characterization and Redox Behavior of Pt(II) and Pt(IV) Complexes with N,N and N,S ligands
ER  - 
@phdthesis{
author = "Mihajlović-Lalić, Ljiljana",
year = "2014",
url = "http://eteze.bg.ac.rs/application/showtheses?thesesId=3252, https://fedorabg.bg.ac.rs/fedora/get/o:11647/bdef:Content/download, http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=47613711, http://nardus.mpn.gov.rs/123456789/5900, http://cherry.chem.bg.ac.rs/handle/123456789/2685",
abstract = "U priloţenoj disertaciji su opisane sinteze, karakterizacija i oksido-redukciona svojstva dialkil estara N,N'-metilen-(S,S)-etilendiamin-N,N'-di-2-(3-cikloheksil) propanske kiseline, njima odgovarajućih kompleksa Pt(IV) kao i kompleksa Pt(II) sa tiofenolat-oksazolinskim ligandom.Spektroskopska karakterizacija sintetisanih jedinjenja je uraĊena standardnim metodama: infracrvenom i Ulj/Vid spektroskopijom, masenom spektrometrijom i NMR spektroskopijom (1D-1H i 13C; 2D-COSY, HSQC, HMBC tehnikama) dok je sastav jedinjenja potvrĊen elementalnom analizom. Struktura kompleksnih jedinjenja platine(II), [Pt(S-Phoz)2] i [Pt(η2S-Phoz)(η1S-Phoz)(PPh3)], odreĊena je i primenom rendgenske strukturne analize.Dialkil estri N,N'-metilen-(S,S)-etilendiamin-N,N'-di-2-(3-cikloheksil)propanske kiseline su dobijeni u reakciji reduktivnog metilovanja dialkil estara (S,S)-etilendiamin-N,N'-di-2-(3-cikloheksil)propanske kiseline triacetoborhidridom i formaldehidom u odgovarajućem stehiometrijskom odnosu. Sintetisani ligandi su reakcijom sa kalijum-heksahloridoplatinatom(IV) dali odgovarajuće komplekse platine(IV), oktaedarske geometrije sa N,N bidentatno vezanim ligandima. Dodatno je za ovu klasu jedinjenja ispitana citotoksiĉna aktivnost na razliĉitim ćelijskim linijama (A375, B16, CT26CL25, HCT116, PC3 i U251).Tiofenolat-oksazolinski ligand, Li(SPh-oz), je s obzirom na prisustvo dva razliĉita donorska atoma (azota i sumpora) pokazao razliĉite naĉine koordinovanja za platinski metalni centar. Prvobitno je reakcijom Li(SPh-oz) sa kalijum-tetrahloridoplatinatom(II) sintetisan [Pt(S-Phoz)2] kompleks deformisane kvadratno-planarne geometrije. Izolovani monokristalni produkt ovog jedinjenja je ukazao na S,S-trans raspored liganada oko metalnog centra. Zatim je u reakciji istog liganda sa cis-bis(trifenilfosfin)platina(II)-hloridom dobijen [Pt(η2S-Phoz)(η1S-Phoz)(PPh3)]..., An enclosed dissertation describes the synthesis, characterization and oxidoreductive properties of dialkyl esters of N,N′-methylene-(S,S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl)propanoic acid, their corresponding Pt(IV) complexes as well as Pt(II) complexes with thiophenolate-oxazoline ligand.Spectroscopic characterization of the synthesized compounds was performed by standard methods: infrared and UV/Vis spectroscopy, mass spectrometry and NMR spectroscopy (1D-1H and 13C and 2D-COSY, HSQC, HMBC techiques) while the compounds' content was confirmed by elemental analysis. The structures of Pt(II) species, [Pt(S-Phoz)2] and [Pt(η2S-Phoz)(η1S-Phoz)(PPh3)], were determined using X-ray structural analysis.Dialkyl esters of N,N′-methylene-(S,S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl)propanoic acid were obtained by reductive methylation of the parent compounds (dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl)propanoic acid) adding triacetoxyborohydride and formaldehyde in appropriate stoichiometric amounts. A reaction between synthesized ligands and potassium tetrachloroplatinate(II) afforded octahedral Pt(IV) complexes giving rise to N,N bidentate coordination. The cytotoxic activity toward various cancer cell lines (A375, B16, CT26CL25, HCT116, PC3 and U251) was additionally investigated for this class of compounds.Thiophenolate-oxazoline ligand, Li(SPh-oz) demonstrated different coordination modes due to the presence of two donor atoms (nitrogen and sulphur). Primarily, [Pt(S-Phoz)2] complex of distorted square planar geometry was obtained in a reaction of Li(SPh-oz) with potassium hexachloroplatinate(IV). The isolated monocrystal product of the specie indicated on S,S-trans arrangement of the ligands around the metal center. Nonetheless, a reaction between the identical ligand and cis-bis(triphenylphosphine)platinum(II) chloride afforded [Pt(η2S-Phoz)(η1S-Phoz)(PPh3)] complex for which 31P NMR spectroscopy and X-ray structural analysis confirmed...",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Sinteza, karakterizacija i redoks ponašanje Pt(II) i Pt(IV) kompleksa sa N,N i N,S ligandima, Synthesis, Characterization and Redox Behavior of Pt(II) and Pt(IV) Complexes with N,N and N,S ligands"
}
Mihajlović-Lalić, L. (2014). Synthesis, Characterization and Redox Behavior of Pt(II) and Pt(IV) Complexes with N,N and N,S ligands.
Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
Mihajlović-Lalić L. Synthesis, Characterization and Redox Behavior of Pt(II) and Pt(IV) Complexes with N,N and N,S ligands. Универзитет у Београду. 2014;
Mihajlović-Lalić Ljiljana, "Synthesis, Characterization and Redox Behavior of Pt(II) and Pt(IV) Complexes with N,N and N,S ligands" Универзитет у Београду (2014)

Novel methylene bridged ethylenediamine-type ligands: synthesis and spectral characterization

Mihajlović-Lalić, Ljiljana; Savić, Aleksandar; Brađan, Gabrijela; Sabo, Tibor; Grgurić-Šipka, Sanja

(Serbian Chemical Soc, Belgrade, 2014)

TY  - JOUR
AU  - Mihajlović-Lalić, Ljiljana
AU  - Savić, Aleksandar
AU  - Brađan, Gabrijela
AU  - Sabo, Tibor
AU  - Grgurić-Šipka, Sanja
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1874
AB  - The synthesis of two new organic compounds, diisobutyl- and diisopentyl (S,S)-alpha(1),alpha(3)-bis(cyclohexylmethyl-1,3-imidazolidinediacetate is reported herein. The one-pot procedure was realized by the addition of the reducing agent and carbonyl compound into a methanolic solution of the parent compounds (isobutyl and isopentyl esters of (S,S)-alpha,alpha '-(1,2-ethanediyldiimino)bis[cyclohexanepropanoic acid] in appropriate stoichiometric ratios. The compounds were fully characterized by infrared, ESI-MS, 1D (H-1 and C-13) and 2D (COSY, HSQC and HMBC) NMR spectroscopy and elemental analysis. The spectral data confirmed the presence of the -CH2- group introduced between the nitrogen atoms of the ethylenediamine moiety, revealing a neutral form of the potential bidentate ligand.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Novel methylene bridged ethylenediamine-type ligands: synthesis and spectral characterization
VL  - 79
IS  - 10
SP  - 1199
EP  - 1204
DO  - 10.2298/JSC140212042M
ER  - 
@article{
author = "Mihajlović-Lalić, Ljiljana and Savić, Aleksandar and Brađan, Gabrijela and Sabo, Tibor and Grgurić-Šipka, Sanja",
year = "2014",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1874",
abstract = "The synthesis of two new organic compounds, diisobutyl- and diisopentyl (S,S)-alpha(1),alpha(3)-bis(cyclohexylmethyl-1,3-imidazolidinediacetate is reported herein. The one-pot procedure was realized by the addition of the reducing agent and carbonyl compound into a methanolic solution of the parent compounds (isobutyl and isopentyl esters of (S,S)-alpha,alpha '-(1,2-ethanediyldiimino)bis[cyclohexanepropanoic acid] in appropriate stoichiometric ratios. The compounds were fully characterized by infrared, ESI-MS, 1D (H-1 and C-13) and 2D (COSY, HSQC and HMBC) NMR spectroscopy and elemental analysis. The spectral data confirmed the presence of the -CH2- group introduced between the nitrogen atoms of the ethylenediamine moiety, revealing a neutral form of the potential bidentate ligand.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Novel methylene bridged ethylenediamine-type ligands: synthesis and spectral characterization",
volume = "79",
number = "10",
pages = "1199-1204",
doi = "10.2298/JSC140212042M"
}
Mihajlović-Lalić, L., Savić, A., Brađan, G., Sabo, T.,& Grgurić-Šipka, S. (2014). Novel methylene bridged ethylenediamine-type ligands: synthesis and spectral characterization.
Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(10), 1199-1204.
https://doi.org/10.2298/JSC140212042M
Mihajlović-Lalić L, Savić A, Brađan G, Sabo T, Grgurić-Šipka S. Novel methylene bridged ethylenediamine-type ligands: synthesis and spectral characterization. Journal of the Serbian Chemical Society. 2014;79(10):1199-1204
Mihajlović-Lalić Ljiljana, Savić Aleksandar, Brađan Gabrijela, Sabo Tibor, Grgurić-Šipka Sanja, "Novel methylene bridged ethylenediamine-type ligands: synthesis and spectral characterization" Journal of the Serbian Chemical Society, 79, no. 10 (2014):1199-1204,
https://doi.org/10.2298/JSC140212042M .
1
1
1

Synthesis, characterization and ROS-mediated cytotoxic action of novel (S, S)-1,3-propanediamine-N,N '-di-2-(3-cyclohexyl)propanoic acid and corresponding esters

Savić, Aleksandar; Misirlić-Denčić, Sonja; Dulović, Marija; Mihajlović-Lalić, Ljiljana; Jovanović, Maja; Grgurić-Šipka, Sanja; Marković, Ivanka; Sabo, Tibor

(Academic Press Inc Elsevier Science, San Diego, 2014)

TY  - JOUR
AU  - Savić, Aleksandar
AU  - Misirlić-Denčić, Sonja
AU  - Dulović, Marija
AU  - Mihajlović-Lalić, Ljiljana
AU  - Jovanović, Maja
AU  - Grgurić-Šipka, Sanja
AU  - Marković, Ivanka
AU  - Sabo, Tibor
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1811
AB  - This study involves the synthesis and characterization of novel cyclohexyl 1,3-propanediamine-N, N'-diacetate molecules as well as investigation of their cytotoxic action. New acid 1a was synthesized by reaction between (S)-2-amino-3-cyclohexylpropanoic acid and 1,3-dibromopropane, while the esters (1b-1e) derived from this acid were obtained by reaction of the corresponding absolute alcohol, thionyl chloride and synthesized acid. All compounds were characterized by IR, ESI-MS, (H-1, C-13 and HSQC) NMR spectroscopy and elemental analysis. The cytotoxic activity of all compounds was tested on several tumour cell lines: human (U251) and rat (C6) glioma, human promyelocytic leukaemia (HL-60), human neuroblastoma (SHSY-5Y) and mouse fibrosarcoma (L929) as well as primary rat astrocytes. The present study reveals potent antitumour activity of novel purely organic compounds (1a-1e), which was most pronounced in human glioma (U251) cells. The esterification is required for the novel compounds' cytotoxic action since the n-butyl ester 1e was the most efficient compound. Importantly, n-butyl ester 1e was more toxic to glioma cells in comparison to rat astrocytes, with 24-h IC50 values lower than those for cisplatin. n-Butyl ester 1e induced production of reactive oxygen species (ROS) and caused an oxidative- stress-derived accumulation of glioma cells in the G(0)/G(1) phase of the cell cycle, as well as caspase activation and DNA fragmentation, suggesting that apoptosis induction plays an important role in the novel compounds' antiglioma action. (C) 2014 Elsevier Inc. All rights reserved.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Bioorganic Chemistry
T1  - Synthesis, characterization and ROS-mediated cytotoxic action of novel (S, S)-1,3-propanediamine-N,N '-di-2-(3-cyclohexyl)propanoic acid and corresponding esters
VL  - 54
SP  - 73
EP  - 80
DO  - 10.1016/j.bioorg.2014.04.006
ER  - 
@article{
author = "Savić, Aleksandar and Misirlić-Denčić, Sonja and Dulović, Marija and Mihajlović-Lalić, Ljiljana and Jovanović, Maja and Grgurić-Šipka, Sanja and Marković, Ivanka and Sabo, Tibor",
year = "2014",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1811",
abstract = "This study involves the synthesis and characterization of novel cyclohexyl 1,3-propanediamine-N, N'-diacetate molecules as well as investigation of their cytotoxic action. New acid 1a was synthesized by reaction between (S)-2-amino-3-cyclohexylpropanoic acid and 1,3-dibromopropane, while the esters (1b-1e) derived from this acid were obtained by reaction of the corresponding absolute alcohol, thionyl chloride and synthesized acid. All compounds were characterized by IR, ESI-MS, (H-1, C-13 and HSQC) NMR spectroscopy and elemental analysis. The cytotoxic activity of all compounds was tested on several tumour cell lines: human (U251) and rat (C6) glioma, human promyelocytic leukaemia (HL-60), human neuroblastoma (SHSY-5Y) and mouse fibrosarcoma (L929) as well as primary rat astrocytes. The present study reveals potent antitumour activity of novel purely organic compounds (1a-1e), which was most pronounced in human glioma (U251) cells. The esterification is required for the novel compounds' cytotoxic action since the n-butyl ester 1e was the most efficient compound. Importantly, n-butyl ester 1e was more toxic to glioma cells in comparison to rat astrocytes, with 24-h IC50 values lower than those for cisplatin. n-Butyl ester 1e induced production of reactive oxygen species (ROS) and caused an oxidative- stress-derived accumulation of glioma cells in the G(0)/G(1) phase of the cell cycle, as well as caspase activation and DNA fragmentation, suggesting that apoptosis induction plays an important role in the novel compounds' antiglioma action. (C) 2014 Elsevier Inc. All rights reserved.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Bioorganic Chemistry",
title = "Synthesis, characterization and ROS-mediated cytotoxic action of novel (S, S)-1,3-propanediamine-N,N '-di-2-(3-cyclohexyl)propanoic acid and corresponding esters",
volume = "54",
pages = "73-80",
doi = "10.1016/j.bioorg.2014.04.006"
}
Savić, A., Misirlić-Denčić, S., Dulović, M., Mihajlović-Lalić, L., Jovanović, M., Grgurić-Šipka, S., Marković, I.,& Sabo, T. (2014). Synthesis, characterization and ROS-mediated cytotoxic action of novel (S, S)-1,3-propanediamine-N,N '-di-2-(3-cyclohexyl)propanoic acid and corresponding esters.
Bioorganic Chemistry
Academic Press Inc Elsevier Science, San Diego., 54, 73-80.
https://doi.org/10.1016/j.bioorg.2014.04.006
Savić A, Misirlić-Denčić S, Dulović M, Mihajlović-Lalić L, Jovanović M, Grgurić-Šipka S, Marković I, Sabo T. Synthesis, characterization and ROS-mediated cytotoxic action of novel (S, S)-1,3-propanediamine-N,N '-di-2-(3-cyclohexyl)propanoic acid and corresponding esters. Bioorganic Chemistry. 2014;54:73-80
Savić Aleksandar, Misirlić-Denčić Sonja, Dulović Marija, Mihajlović-Lalić Ljiljana, Jovanović Maja, Grgurić-Šipka Sanja, Marković Ivanka, Sabo Tibor, "Synthesis, characterization and ROS-mediated cytotoxic action of novel (S, S)-1,3-propanediamine-N,N '-di-2-(3-cyclohexyl)propanoic acid and corresponding esters" Bioorganic Chemistry, 54 (2014):73-80,
https://doi.org/10.1016/j.bioorg.2014.04.006 .
9
11
11

Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands

Mihajlović-Lalić, Ljiljana; Stanković, Dalibor; Poljarević, Jelena; Manojlović, Dragan D.; Sabo, Tibor; Grgurić-Šipka, Sanja

(Esg, Belgrade, 2013)

TY  - JOUR
AU  - Mihajlović-Lalić, Ljiljana
AU  - Stanković, Dalibor
AU  - Poljarević, Jelena
AU  - Manojlović, Dragan D.
AU  - Sabo, Tibor
AU  - Grgurić-Šipka, Sanja
PY  - 2013
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1392
AB  - Pt(IV) complexes with ethylenediamine-N,N'-diacetate-type ligands exhibit strong antitumor activity towards various cancer cell lines. In order to explain their complete mechanisms of action, we examined bioreductive character of eight compounds in total using cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. Recorded voltammograms of all Pt(IV) complexes with methyl, ethyl, n-propyl and n-butyl esters of (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid confirmed two successive one-electron transfer steps followed by the loss of the corresponding axial ligands. The redox potential values for Pt(IV) complexes were in the range of -0.92 V lt Ep lt -0.70 V vs. Ag/AgCl, indicating hard reduction. The obtained electrochemical data pointed to the fact that the length of alkyl substituents influences on the reduction as well as on their biological activity. In addition, the electrochemical data were correlated with the biological data but this correlation wasn't established. The reported electrochemical data well correlated with the biological results pointed to the future structural modifications among the investigated compounds and helped select the most suitable candidates for further research.
PB  - Esg, Belgrade
T2  - International Journal of Electrochemical Science
T1  - Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands
VL  - 8
IS  - 6
SP  - 8433
EP  - 8441
ER  - 
@article{
author = "Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Poljarević, Jelena and Manojlović, Dragan D. and Sabo, Tibor and Grgurić-Šipka, Sanja",
year = "2013",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1392",
abstract = "Pt(IV) complexes with ethylenediamine-N,N'-diacetate-type ligands exhibit strong antitumor activity towards various cancer cell lines. In order to explain their complete mechanisms of action, we examined bioreductive character of eight compounds in total using cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. Recorded voltammograms of all Pt(IV) complexes with methyl, ethyl, n-propyl and n-butyl esters of (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid confirmed two successive one-electron transfer steps followed by the loss of the corresponding axial ligands. The redox potential values for Pt(IV) complexes were in the range of -0.92 V lt Ep lt -0.70 V vs. Ag/AgCl, indicating hard reduction. The obtained electrochemical data pointed to the fact that the length of alkyl substituents influences on the reduction as well as on their biological activity. In addition, the electrochemical data were correlated with the biological data but this correlation wasn't established. The reported electrochemical data well correlated with the biological results pointed to the future structural modifications among the investigated compounds and helped select the most suitable candidates for further research.",
publisher = "Esg, Belgrade",
journal = "International Journal of Electrochemical Science",
title = "Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands",
volume = "8",
number = "6",
pages = "8433-8441"
}
Mihajlović-Lalić, L., Stanković, D., Poljarević, J., Manojlović, D. D., Sabo, T.,& Grgurić-Šipka, S. (2013). Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands.
International Journal of Electrochemical Science
Esg, Belgrade., 8(6), 8433-8441.
Mihajlović-Lalić L, Stanković D, Poljarević J, Manojlović DD, Sabo T, Grgurić-Šipka S. Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands. International Journal of Electrochemical Science. 2013;8(6):8433-8441
Mihajlović-Lalić Ljiljana, Stanković Dalibor, Poljarević Jelena, Manojlović Dragan D., Sabo Tibor, Grgurić-Šipka Sanja, "Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands" International Journal of Electrochemical Science, 8, no. 6 (2013):8433-8441
5
6

Green tea catechins suppress antigen-specific proliferation and cytokine secretion but elevate intracellular oxidative stress in peripheral blood mononuclear cells of pollen allergic individuals

Ognjenović, J.; Mihajlović-Lalić, Ljiljana; Stanić-Vučinić, Dragana; Atanasković-Marković, Marina; Burazer, Lidija M.; Ćirković-Veličković, Tanja

(Wiley-Blackwell, Hoboken, 2012)

TY  - CONF
AU  - Ognjenović, J.
AU  - Mihajlović-Lalić, Ljiljana
AU  - Stanić-Vučinić, Dragana
AU  - Atanasković-Marković, Marina
AU  - Burazer, Lidija M.
AU  - Ćirković-Veličković, Tanja
PY  - 2012
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1544
PB  - Wiley-Blackwell, Hoboken
C3  - Allergy
T1  - Green tea catechins suppress antigen-specific proliferation and cytokine secretion but elevate intracellular oxidative stress in peripheral blood mononuclear cells of pollen allergic individuals
VL  - 67
SP  - 638
EP  - 639
ER  - 
@conference{
author = "Ognjenović, J. and Mihajlović-Lalić, Ljiljana and Stanić-Vučinić, Dragana and Atanasković-Marković, Marina and Burazer, Lidija M. and Ćirković-Veličković, Tanja",
year = "2012",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1544",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Allergy",
title = "Green tea catechins suppress antigen-specific proliferation and cytokine secretion but elevate intracellular oxidative stress in peripheral blood mononuclear cells of pollen allergic individuals",
volume = "67",
pages = "638-639"
}
Ognjenović, J., Mihajlović-Lalić, L., Stanić-Vučinić, D., Atanasković-Marković, M., Burazer, L. M.,& Ćirković-Veličković, T. (2012). Green tea catechins suppress antigen-specific proliferation and cytokine secretion but elevate intracellular oxidative stress in peripheral blood mononuclear cells of pollen allergic individuals.
Allergy
Wiley-Blackwell, Hoboken., 67, 638-639.
Ognjenović J, Mihajlović-Lalić L, Stanić-Vučinić D, Atanasković-Marković M, Burazer LM, Ćirković-Veličković T. Green tea catechins suppress antigen-specific proliferation and cytokine secretion but elevate intracellular oxidative stress in peripheral blood mononuclear cells of pollen allergic individuals. Allergy. 2012;67:638-639
Ognjenović J., Mihajlović-Lalić Ljiljana, Stanić-Vučinić Dragana, Atanasković-Marković Marina, Burazer Lidija M., Ćirković-Veličković Tanja, "Green tea catechins suppress antigen-specific proliferation and cytokine secretion but elevate intracellular oxidative stress in peripheral blood mononuclear cells of pollen allergic individuals" Allergy, 67 (2012):638-639

Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity

Mihajlović-Lalić, Ljiljana; Savić, Aleksandar; Poljarević, Jelena; Vučković, Ivan M.; Mojic, Marija; Bulatović, Mirna Z.; Maksimovic-Ivanic, Danijela; Mijatovic, Sanja; Kaluđerović, Goran N.; Stošić-Grujičić, Stanislava D.; Miljkovic, Dorde; Grgurić-Šipka, Sanja; Sabo, Tibor

(Elsevier Science Inc, New York, 2012)

TY  - JOUR
AU  - Mihajlović-Lalić, Ljiljana
AU  - Savić, Aleksandar
AU  - Poljarević, Jelena
AU  - Vučković, Ivan M.
AU  - Mojic, Marija
AU  - Bulatović, Mirna Z.
AU  - Maksimovic-Ivanic, Danijela
AU  - Mijatovic, Sanja
AU  - Kaluđerović, Goran N.
AU  - Stošić-Grujičić, Stanislava D.
AU  - Miljkovic, Dorde
AU  - Grgurić-Šipka, Sanja
AU  - Sabo, Tibor
PY  - 2012
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1283
AB  - This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity
VL  - 109
SP  - 40
EP  - 48
DO  - 10.1016/j.jinorgbio.2012.01.012
ER  - 
@article{
author = "Mihajlović-Lalić, Ljiljana and Savić, Aleksandar and Poljarević, Jelena and Vučković, Ivan M. and Mojic, Marija and Bulatović, Mirna Z. and Maksimovic-Ivanic, Danijela and Mijatovic, Sanja and Kaluđerović, Goran N. and Stošić-Grujičić, Stanislava D. and Miljkovic, Dorde and Grgurić-Šipka, Sanja and Sabo, Tibor",
year = "2012",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1283",
abstract = "This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity",
volume = "109",
pages = "40-48",
doi = "10.1016/j.jinorgbio.2012.01.012"
}
Mihajlović-Lalić, L., Savić, A., Poljarević, J., Vučković, I. M., Mojic, M., Bulatović, M. Z., Maksimovic-Ivanic, D., Mijatovic, S., Kaluđerović, G. N., Stošić-Grujičić, S. D., Miljkovic, D., Grgurić-Šipka, S.,& Sabo, T. (2012). Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity.
Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 109, 40-48.
https://doi.org/10.1016/j.jinorgbio.2012.01.012
Mihajlović-Lalić L, Savić A, Poljarević J, Vučković IM, Mojic M, Bulatović MZ, Maksimovic-Ivanic D, Mijatovic S, Kaluđerović GN, Stošić-Grujičić SD, Miljkovic D, Grgurić-Šipka S, Sabo T. Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. Journal of Inorganic Biochemistry. 2012;109:40-48
Mihajlović-Lalić Ljiljana, Savić Aleksandar, Poljarević Jelena, Vučković Ivan M., Mojic Marija, Bulatović Mirna Z., Maksimovic-Ivanic Danijela, Mijatovic Sanja, Kaluđerović Goran N., Stošić-Grujičić Stanislava D., Miljkovic Dorde, Grgurić-Šipka Sanja, Sabo Tibor, "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity" Journal of Inorganic Biochemistry, 109 (2012):40-48,
https://doi.org/10.1016/j.jinorgbio.2012.01.012 .
24
27
29

Separation of amino acids, peptides, and proteins by ion exchange chromatography

Ćirković-Veličković, Tanja; Ognjenović, J.; Mihajlović-Lalić, Ljiljana

(2012)

TY  - CHAP
AU  - Ćirković-Veličković, Tanja
AU  - Ognjenović, J.
AU  - Mihajlović-Lalić, Ljiljana
PY  - 2012
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/290
AB  - Separation of amino acids, peptides, and proteins (bioanalytes) via ion exchange (IE) has widespread usage because it is usually very simple to design and it has high capacity and easily achievable control of the separation process. Amino acids, as principal constituents of proteins and having a plethora of biological functions of their own, are always in focus when developing novel methods. Separation and quantification of amino acids is essential in food science, medicine, agricultural science, etc. Peptides exist in nature and have diverse functions. Digestion of proteins by enzymes also gives complex mixtures of peptides and IE finds its application in peptide separation. There are lots of reasons for the popularity of IE in protein isolation and purification. It is used in research, analysis, and large-scale purification of proteins. Ion exchange is ideal for the initial capture of proteins because of its high capacity, relatively low cost, and its ability to survive rigorous cleaning regimes. This chapter covers basic principles and modern applications of IE in separation of amino acids, peptides, and proteins. © 2012 Springer Science+Business Media B.V. All rights are reserved.
T1  - Separation of amino acids, peptides, and proteins by ion exchange chromatography
SP  - 1
EP  - 34
DO  - 10.1007/978-94-007-4026-6_1
ER  - 
@article{
author = "Ćirković-Veličković, Tanja and Ognjenović, J. and Mihajlović-Lalić, Ljiljana",
year = "2012",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/290",
abstract = "Separation of amino acids, peptides, and proteins (bioanalytes) via ion exchange (IE) has widespread usage because it is usually very simple to design and it has high capacity and easily achievable control of the separation process. Amino acids, as principal constituents of proteins and having a plethora of biological functions of their own, are always in focus when developing novel methods. Separation and quantification of amino acids is essential in food science, medicine, agricultural science, etc. Peptides exist in nature and have diverse functions. Digestion of proteins by enzymes also gives complex mixtures of peptides and IE finds its application in peptide separation. There are lots of reasons for the popularity of IE in protein isolation and purification. It is used in research, analysis, and large-scale purification of proteins. Ion exchange is ideal for the initial capture of proteins because of its high capacity, relatively low cost, and its ability to survive rigorous cleaning regimes. This chapter covers basic principles and modern applications of IE in separation of amino acids, peptides, and proteins. © 2012 Springer Science+Business Media B.V. All rights are reserved.",
title = "Separation of amino acids, peptides, and proteins by ion exchange chromatography",
pages = "1-34",
doi = "10.1007/978-94-007-4026-6_1"
}
Ćirković-Veličković, T., Ognjenović, J.,& Mihajlović-Lalić, L. (2012). Separation of amino acids, peptides, and proteins by ion exchange chromatography.
, 1-34.
https://doi.org/10.1007/978-94-007-4026-6_1
Ćirković-Veličković T, Ognjenović J, Mihajlović-Lalić L. Separation of amino acids, peptides, and proteins by ion exchange chromatography. 2012;:1-34
Ćirković-Veličković Tanja, Ognjenović J., Mihajlović-Lalić Ljiljana, "Separation of amino acids, peptides, and proteins by ion exchange chromatography" (2012):1-34,
https://doi.org/10.1007/978-94-007-4026-6_1 .
9
9