TY  - JOUR
AU  - Pfendt, Lidija B.
AU  - Sladić, Dušan
AU  - Janjić, Tomislav J.
AU  - Popović, Gordana V.
PY  - 1990
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/20
AB  - Acid-base equilibria in heterogeneous and homogeneous systems of some sparingly soluble benzodiazepines (diazepam, prazepam, chlordiazepoxide and medazepam) were investigated in aqueous solution and the corresponding equilibrium constants were determined by the application of pH-metric, spectrophotometric and solubility methods. The sites of protonation were predicted on the basis of the analysis of the corresponding carbon-13 nuclear magnetic resonance spectra. In addition, buffer characteristics of saturated aqueous solutions of these drugs in the presence of the solid phase were investigated and it was established that they possess a very high buffer capacity over a specific pH range.
T2  - Analyst
T1  - Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines
VL  - 115
IS  - 4
SP  - 383
EP  - 387
DO  - 10.1039/an9901500383
ER  - 

@article{
author = "Pfendt, Lidija B. and Sladić, Dušan and Janjić, Tomislav J. and Popović, Gordana V.",
year = "1990",
abstract = "Acid-base equilibria in heterogeneous and homogeneous systems of some sparingly soluble benzodiazepines (diazepam, prazepam, chlordiazepoxide and medazepam) were investigated in aqueous solution and the corresponding equilibrium constants were determined by the application of pH-metric, spectrophotometric and solubility methods. The sites of protonation were predicted on the basis of the analysis of the corresponding carbon-13 nuclear magnetic resonance spectra. In addition, buffer characteristics of saturated aqueous solutions of these drugs in the presence of the solid phase were investigated and it was established that they possess a very high buffer capacity over a specific pH range.",
journal = "Analyst",
title = "Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines",
volume = "115",
number = "4",
pages = "383-387",
doi = "10.1039/an9901500383"
}

Pfendt, L. B., Sladić, D., Janjić, T. J.,& Popović, G. V.. (1990). Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines. in Analyst, 115(4), 383-387.
https://doi.org/10.1039/an9901500383

Pfendt LB, Sladić D, Janjić TJ, Popović GV. Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines. in Analyst. 1990;115(4):383-387.
doi:10.1039/an9901500383 .

Pfendt, Lidija B., Sladić, Dušan, Janjić, Tomislav J., Popović, Gordana V., "Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines" in Analyst, 115, no. 4 (1990):383-387,
https://doi.org/10.1039/an9901500383 . .