TY  - JOUR
AU  - Pfendt, Lidija B.
AU  - Popović, Gordana V.
AU  - Damjanović, Tatjana Ž.
AU  - Sladić, Dušan
PY  - 2002
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/484
AB  - The protolytic equilibria of bromazepam, an ampholyte sparingly soluble in water, in homogeneous and heterogeneous systems were studied in the pH range 0-14 at 25 degreesC and at ionic strength of 0.1 mol/dm(3) (NaCl). On the basis of C-13-NMR spectra, the protonation site was predicted - in acidic media the pyridine nitrogen of bormazepam is protonated. The acidity constants of bromazepam were determined spectrophotometrically (pK(a1) 2.83 and pK(a2) 11.60) and potentiometrically (pk(a1) 2.99). In the heterogeneous system the following equilibrium constants were determined: K-s0 = [HA] (pK(s0) 3.44), K-s1 = [H(2)A(+)]/[H3O+] (pK(s1) 0.61), and K-s2 = [A(-)][H3O+] (pK(s2) 15.04).
AB  - Proučavane su protolitičke ravnoteže bromazepama, amfolita iz klase 1,4-benzodiazepina, slabo rastvornog u vodi. Ispitivanja su vršena u homogenom i heterogenom sistemu u pH intervalu 0–14, na temperaturi 25ºC i pri jonskoj sili 0,1 mol/dm3 (NaCl). Na osnovu 13C-NMR spektara pretpostavljeno je da do protonovanja u molekulu bromazepama dolazi na piridinskom atomu azota. Kiselinske konstante određene su spektrofotometrijski (pKa1 2.83 and pKa2 11.60) i potenciometrijski (pKa1 2,99). U heterogenom sistemu određene su sledeće ravnotežne konstante Ks0 =[HA](pKs0 3.44), Ks1=[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Protolytic equilibria of bromazepam
T1  - Protolitičke ravnoteže bromazepama
VL  - 67
IS  - 3
SP  - 187
EP  - 195
DO  - 10.2298/JSC0203187P
ER  - 

@article{
author = "Pfendt, Lidija B. and Popović, Gordana V. and Damjanović, Tatjana Ž. and Sladić, Dušan",
year = "2002",
abstract = "The protolytic equilibria of bromazepam, an ampholyte sparingly soluble in water, in homogeneous and heterogeneous systems were studied in the pH range 0-14 at 25 degreesC and at ionic strength of 0.1 mol/dm(3) (NaCl). On the basis of C-13-NMR spectra, the protonation site was predicted - in acidic media the pyridine nitrogen of bormazepam is protonated. The acidity constants of bromazepam were determined spectrophotometrically (pK(a1) 2.83 and pK(a2) 11.60) and potentiometrically (pk(a1) 2.99). In the heterogeneous system the following equilibrium constants were determined: K-s0 = [HA] (pK(s0) 3.44), K-s1 = [H(2)A(+)]/[H3O+] (pK(s1) 0.61), and K-s2 = [A(-)][H3O+] (pK(s2) 15.04)., Proučavane su protolitičke ravnoteže bromazepama, amfolita iz klase 1,4-benzodiazepina, slabo rastvornog u vodi. Ispitivanja su vršena u homogenom i heterogenom sistemu u pH intervalu 0–14, na temperaturi 25ºC i pri jonskoj sili 0,1 mol/dm3 (NaCl). Na osnovu 13C-NMR spektara pretpostavljeno je da do protonovanja u molekulu bromazepama dolazi na piridinskom atomu azota. Kiselinske konstante određene su spektrofotometrijski (pKa1 2.83 and pKa2 11.60) i potenciometrijski (pKa1 2,99). U heterogenom sistemu određene su sledeće ravnotežne konstante Ks0 =[HA](pKs0 3.44), Ks1=[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Protolytic equilibria of bromazepam, Protolitičke ravnoteže bromazepama",
volume = "67",
number = "3",
pages = "187-195",
doi = "10.2298/JSC0203187P"
}

Pfendt, L. B., Popović, G. V., Damjanović, T. Ž.,& Sladić, D.. (2002). Protolytic equilibria of bromazepam. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 67(3), 187-195.
https://doi.org/10.2298/JSC0203187P

Pfendt LB, Popović GV, Damjanović TŽ, Sladić D. Protolytic equilibria of bromazepam. in Journal of the Serbian Chemical Society. 2002;67(3):187-195.
doi:10.2298/JSC0203187P .

Pfendt, Lidija B., Popović, Gordana V., Damjanović, Tatjana Ž., Sladić, Dušan, "Protolytic equilibria of bromazepam" in Journal of the Serbian Chemical Society, 67, no. 3 (2002):187-195,
https://doi.org/10.2298/JSC0203187P . .

TY  - CONF
AU  - Popović, Gordana V.
AU  - Damjanović, Tatjana Ž.
AU  - Sladić, Dušan
AU  - Pfendt, Lidija B.
PY  - 2002
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/129
C3  - Arhiv za farmaciju
T1  - Identification of the diazepine ring opening site in the reaction of acidic hydrolysis of bromazepam
T1  - Identifikacija mesta hidrolitičkog otvaranja diazepinskog prstena bromazepama u kiseloj sredini
VL  - 52
IS  - 4
SP  - 462
EP  - 463
UR  - https://hdl.handle.net/21.15107/rcub_cherry_129
ER  - 

@conference{
author = "Popović, Gordana V. and Damjanović, Tatjana Ž. and Sladić, Dušan and Pfendt, Lidija B.",
year = "2002",
journal = "Arhiv za farmaciju",
title = "Identification of the diazepine ring opening site in the reaction of acidic hydrolysis of bromazepam, Identifikacija mesta hidrolitičkog otvaranja diazepinskog prstena bromazepama u kiseloj sredini",
volume = "52",
number = "4",
pages = "462-463",
url = "https://hdl.handle.net/21.15107/rcub_cherry_129"
}

Popović, G. V., Damjanović, T. Ž., Sladić, D.,& Pfendt, L. B.. (2002). Identification of the diazepine ring opening site in the reaction of acidic hydrolysis of bromazepam. in Arhiv za farmaciju, 52(4), 462-463.
https://hdl.handle.net/21.15107/rcub_cherry_129

Popović GV, Damjanović TŽ, Sladić D, Pfendt LB. Identification of the diazepine ring opening site in the reaction of acidic hydrolysis of bromazepam. in Arhiv za farmaciju. 2002;52(4):462-463.
https://hdl.handle.net/21.15107/rcub_cherry_129 .

Popović, Gordana V., Damjanović, Tatjana Ž., Sladić, Dušan, Pfendt, Lidija B., "Identification of the diazepine ring opening site in the reaction of acidic hydrolysis of bromazepam" in Arhiv za farmaciju, 52, no. 4 (2002):462-463,
https://hdl.handle.net/21.15107/rcub_cherry_129 .