TY  - JOUR
AU  - Atanasković-Marković, Marina
AU  - Janković, Jelena
AU  - Tmušić, Vladimir
AU  - Gavrović-Jankulović, Marija
AU  - Ćirković-Veličković, Tanja
AU  - Nikolić, Dimitrije
AU  - Škorić, Dejan
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3704
AB  - Background: Antiepileptic drugs (AEDs) can cause hypersensitivity reactions in children. These reactions are mainly cutaneous, self-limiting, and benign, but life-threatening severe cutaneous adverse reactions can occur. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions, if a drug is taken at the same time. The aims of our study were to confirm or rule out the diagnosis of hypersensitivity reactions to AEDs in children and to detect an infection which mimics these reactions. Methods: A prospective survey was conducted in a group of 100 children with histories of hypersensitivity reactions to AEDs by performing patch tests, delayed-reading intradermal test, and, in case of negative results, challenge test. In all children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. Results: Maculopapular exanthema and delayed-appearing urticaria were the most reported hypersensitivity reactions to AEDs. Sixty-six (66%) of 100 children had confirmed hypersensitivity reactions to AEDs. Fifty-nine children had positive patch test. No children had positive challenge tests. The most common AEDs causing hypersensitivity reactions were carbamazepine (45.4%) and lamotrigine (43.6%). Thirty-two children had positive tests for viruses or M pneumoniae, and nine of them had also a positive allergy work-up. Conclusion: Considering that there are no specific tests to distinguish between a viral infection and hypersensitivity reactions to AEDs in the acute phase, a diagnostic work-up should be performed in all children with suspected hypersensitivity reactions to AEDs, as well as infectious agent study, to remove a false label of hypersensitivity.
PB  - John Wiley and Sons Ltd.
T2  - Pediatric Allergy and Immunology
T1  - Hypersensitivity reactions to antiepileptic drugs in children
VL  - 30
IS  - 5
SP  - 547
EP  - 552
DO  - 10.1111/pai.13055
ER  - 

@article{
author = "Atanasković-Marković, Marina and Janković, Jelena and Tmušić, Vladimir and Gavrović-Jankulović, Marija and Ćirković-Veličković, Tanja and Nikolić, Dimitrije and Škorić, Dejan",
year = "2019",
abstract = "Background: Antiepileptic drugs (AEDs) can cause hypersensitivity reactions in children. These reactions are mainly cutaneous, self-limiting, and benign, but life-threatening severe cutaneous adverse reactions can occur. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions, if a drug is taken at the same time. The aims of our study were to confirm or rule out the diagnosis of hypersensitivity reactions to AEDs in children and to detect an infection which mimics these reactions. Methods: A prospective survey was conducted in a group of 100 children with histories of hypersensitivity reactions to AEDs by performing patch tests, delayed-reading intradermal test, and, in case of negative results, challenge test. In all children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. Results: Maculopapular exanthema and delayed-appearing urticaria were the most reported hypersensitivity reactions to AEDs. Sixty-six (66%) of 100 children had confirmed hypersensitivity reactions to AEDs. Fifty-nine children had positive patch test. No children had positive challenge tests. The most common AEDs causing hypersensitivity reactions were carbamazepine (45.4%) and lamotrigine (43.6%). Thirty-two children had positive tests for viruses or M pneumoniae, and nine of them had also a positive allergy work-up. Conclusion: Considering that there are no specific tests to distinguish between a viral infection and hypersensitivity reactions to AEDs in the acute phase, a diagnostic work-up should be performed in all children with suspected hypersensitivity reactions to AEDs, as well as infectious agent study, to remove a false label of hypersensitivity.",
publisher = "John Wiley and Sons Ltd.",
journal = "Pediatric Allergy and Immunology",
title = "Hypersensitivity reactions to antiepileptic drugs in children",
volume = "30",
number = "5",
pages = "547-552",
doi = "10.1111/pai.13055"
}

Atanasković-Marković, M., Janković, J., Tmušić, V., Gavrović-Jankulović, M., Ćirković-Veličković, T., Nikolić, D.,& Škorić, D.. (2019). Hypersensitivity reactions to antiepileptic drugs in children. in Pediatric Allergy and Immunology
John Wiley and Sons Ltd.., 30(5), 547-552.
https://doi.org/10.1111/pai.13055

Atanasković-Marković M, Janković J, Tmušić V, Gavrović-Jankulović M, Ćirković-Veličković T, Nikolić D, Škorić D. Hypersensitivity reactions to antiepileptic drugs in children. in Pediatric Allergy and Immunology. 2019;30(5):547-552.
doi:10.1111/pai.13055 .

Atanasković-Marković, Marina, Janković, Jelena, Tmušić, Vladimir, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Nikolić, Dimitrije, Škorić, Dejan, "Hypersensitivity reactions to antiepileptic drugs in children" in Pediatric Allergy and Immunology, 30, no. 5 (2019):547-552,
https://doi.org/10.1111/pai.13055 . .

TY  - JOUR
AU  - Zivanovic, Mirjana
AU  - Atanasković-Marković, Marina
AU  - Međo, Biljana
AU  - Gavrović-Jankulović, Marija
AU  - Smiljanić, Katarina
AU  - Tmušić, Vladimir
AU  - Đurić, Vojislav
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2469
AB  - IgE-mediated food allergy affects 6-8% of children. Our study aimed to define the correlations between the results obtained with skin prick tests (SPTs) using commercial extracts and fresh foods, and the correlations between these result and those obtained with specific IgE (sIgE) and/or challenge. Children aged from 2 months to 6 years were recruited prospectively. Overall 571 children were positive to one food. In all children we performed SPT using commercial extracts of suspected food and fresh foods and sIgE. If SPT and sIgE test results did not correspond to the history, we performed open oral food challenge. Sensitivity of SPT with commercial extracts for all tested food was poor (3-35%), while sensitivity of fresh food skin prick tests (FFSPT) was excellent (50-100%), and showed correlation with open oral food challenge (p lt 0.001). Our results suggest that fresh food extracts are more effective in detecting sensitization and with levels of sIgE greater than class 3 could predict clinical reactivity, without the need for potentially hazardous food challenges.
PB  - Iranian Scientific Society Medical Entomology, Tehran
T2  - Iranian Journal of Allergy Asthma and Immunology
T1  - Evaluation of Food Allergy in Children by Skin Prick Tests with Commercial Extracts and Fresh Foods, Specific IgE and, Open Oral Food Challenge: Our Five Years Experience in Food Allergy Work-up
VL  - 16
IS  - 2
SP  - 127
EP  - 132
UR  - https://hdl.handle.net/21.15107/rcub_cherry_2469
ER  - 

@article{
author = "Zivanovic, Mirjana and Atanasković-Marković, Marina and Međo, Biljana and Gavrović-Jankulović, Marija and Smiljanić, Katarina and Tmušić, Vladimir and Đurić, Vojislav",
year = "2017",
abstract = "IgE-mediated food allergy affects 6-8% of children. Our study aimed to define the correlations between the results obtained with skin prick tests (SPTs) using commercial extracts and fresh foods, and the correlations between these result and those obtained with specific IgE (sIgE) and/or challenge. Children aged from 2 months to 6 years were recruited prospectively. Overall 571 children were positive to one food. In all children we performed SPT using commercial extracts of suspected food and fresh foods and sIgE. If SPT and sIgE test results did not correspond to the history, we performed open oral food challenge. Sensitivity of SPT with commercial extracts for all tested food was poor (3-35%), while sensitivity of fresh food skin prick tests (FFSPT) was excellent (50-100%), and showed correlation with open oral food challenge (p lt 0.001). Our results suggest that fresh food extracts are more effective in detecting sensitization and with levels of sIgE greater than class 3 could predict clinical reactivity, without the need for potentially hazardous food challenges.",
publisher = "Iranian Scientific Society Medical Entomology, Tehran",
journal = "Iranian Journal of Allergy Asthma and Immunology",
title = "Evaluation of Food Allergy in Children by Skin Prick Tests with Commercial Extracts and Fresh Foods, Specific IgE and, Open Oral Food Challenge: Our Five Years Experience in Food Allergy Work-up",
volume = "16",
number = "2",
pages = "127-132",
url = "https://hdl.handle.net/21.15107/rcub_cherry_2469"
}

Zivanovic, M., Atanasković-Marković, M., Međo, B., Gavrović-Jankulović, M., Smiljanić, K., Tmušić, V.,& Đurić, V.. (2017). Evaluation of Food Allergy in Children by Skin Prick Tests with Commercial Extracts and Fresh Foods, Specific IgE and, Open Oral Food Challenge: Our Five Years Experience in Food Allergy Work-up. in Iranian Journal of Allergy Asthma and Immunology
Iranian Scientific Society Medical Entomology, Tehran., 16(2), 127-132.
https://hdl.handle.net/21.15107/rcub_cherry_2469

Zivanovic M, Atanasković-Marković M, Međo B, Gavrović-Jankulović M, Smiljanić K, Tmušić V, Đurić V. Evaluation of Food Allergy in Children by Skin Prick Tests with Commercial Extracts and Fresh Foods, Specific IgE and, Open Oral Food Challenge: Our Five Years Experience in Food Allergy Work-up. in Iranian Journal of Allergy Asthma and Immunology. 2017;16(2):127-132.
https://hdl.handle.net/21.15107/rcub_cherry_2469 .

Zivanovic, Mirjana, Atanasković-Marković, Marina, Međo, Biljana, Gavrović-Jankulović, Marija, Smiljanić, Katarina, Tmušić, Vladimir, Đurić, Vojislav, "Evaluation of Food Allergy in Children by Skin Prick Tests with Commercial Extracts and Fresh Foods, Specific IgE and, Open Oral Food Challenge: Our Five Years Experience in Food Allergy Work-up" in Iranian Journal of Allergy Asthma and Immunology, 16, no. 2 (2017):127-132,
https://hdl.handle.net/21.15107/rcub_cherry_2469 .

TY  - JOUR
AU  - Atanasković-Marković, Marina
AU  - Gaeta, Francesco
AU  - Međo, Biljana
AU  - Gavrović-Jankulović, Marija
AU  - Ćirković-Veličković, Tanja
AU  - Tmušić, Vladimir
AU  - Romano, Antonino
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2278
AB  - BackgroundNon-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as drug allergic' after considering only the clinical history. ObjectiveTo diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL MethodsA prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. ResultsUrticaria and maculopapular exanthemas were the most reported non-immediate reactions. Only 76 (7.4%) of 1026 children had confirmed non-immediate hypersensitivity reactions to BL. Fifty-seven children had positive delayed-reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT. Sixty-six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work-up. ConclusionsA diagnostic work-up should be performed in all children with non-immediate reactions to BL, to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed-reading intradermal tests to BL, such tests appear to be useful in order to reduce the risk for positive DPTs.
PB  - Wiley, Hoboken
T2  - Pediatric Allergy and Immunology
T1  - Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up
VL  - 27
IS  - 5
SP  - 533
EP  - 538
DO  - 10.1111/pai.12565
ER  - 

@article{
author = "Atanasković-Marković, Marina and Gaeta, Francesco and Međo, Biljana and Gavrović-Jankulović, Marija and Ćirković-Veličković, Tanja and Tmušić, Vladimir and Romano, Antonino",
year = "2016",
abstract = "BackgroundNon-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as drug allergic' after considering only the clinical history. ObjectiveTo diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL MethodsA prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs). In 300 children, a study was performed to detect infections by viruses or Mycoplasma pneumoniae. ResultsUrticaria and maculopapular exanthemas were the most reported non-immediate reactions. Only 76 (7.4%) of 1026 children had confirmed non-immediate hypersensitivity reactions to BL. Fifty-seven children had positive delayed-reading intradermal tests (18 of these with a positive patch test). Nineteen children had positive DPT. Sixty-six of 300 children had positive tests for viruses or Mycoplasma pneumoniae and 2 of them had a positive allergy work-up. ConclusionsA diagnostic work-up should be performed in all children with non-immediate reactions to BL, to remove a false label of hypersensitivity. Even though only 57 (5.5%) of 1026 children displayed positive responses to delayed-reading intradermal tests to BL, such tests appear to be useful in order to reduce the risk for positive DPTs.",
publisher = "Wiley, Hoboken",
journal = "Pediatric Allergy and Immunology",
title = "Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up",
volume = "27",
number = "5",
pages = "533-538",
doi = "10.1111/pai.12565"
}

Atanasković-Marković, M., Gaeta, F., Međo, B., Gavrović-Jankulović, M., Ćirković-Veličković, T., Tmušić, V.,& Romano, A.. (2016). Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up. in Pediatric Allergy and Immunology
Wiley, Hoboken., 27(5), 533-538.
https://doi.org/10.1111/pai.12565

Atanasković-Marković M, Gaeta F, Međo B, Gavrović-Jankulović M, Ćirković-Veličković T, Tmušić V, Romano A. Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up. in Pediatric Allergy and Immunology. 2016;27(5):533-538.
doi:10.1111/pai.12565 .

Atanasković-Marković, Marina, Gaeta, Francesco, Međo, Biljana, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Tmušić, Vladimir, Romano, Antonino, "Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up" in Pediatric Allergy and Immunology, 27, no. 5 (2016):533-538,
https://doi.org/10.1111/pai.12565 . .