TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Bogdanović, Gordana
AU  - Kojić, Vesna
AU  - Tešević, Vele
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2446
AB  - The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs. (C) 2013 Production and hosting by Elsevier B.V.
PB  - Elsevier Science Bv, Amsterdam
T2  - Arabian Journal of Chemistry
T1  - Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells
VL  - 10
SP  - 1240
EP  - 1242
DO  - 10.1016/j.arabjc.2013.03.003
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Bogdanović, Gordana and Kojić, Vesna and Tešević, Vele",
year = "2017",
abstract = "The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs. (C) 2013 Production and hosting by Elsevier B.V.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Arabian Journal of Chemistry",
title = "Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells",
volume = "10",
pages = "1240-1242",
doi = "10.1016/j.arabjc.2013.03.003"
}

Pejin, B., Iodice, C., Bogdanović, G., Kojić, V.,& Tešević, V.. (2017). Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells. in Arabian Journal of Chemistry
Elsevier Science Bv, Amsterdam., 10, 1240-1242.
https://doi.org/10.1016/j.arabjc.2013.03.003

Pejin B, Iodice C, Bogdanović G, Kojić V, Tešević V. Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells. in Arabian Journal of Chemistry. 2017;10:1240-1242.
doi:10.1016/j.arabjc.2013.03.003 .

Pejin, Boris, Iodice, Carmine, Bogdanović, Gordana, Kojić, Vesna, Tešević, Vele, "Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells" in Arabian Journal of Chemistry, 10 (2017):1240-1242,
https://doi.org/10.1016/j.arabjc.2013.03.003 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Stanimirović, Bojana
AU  - Vajs, Vlatka
AU  - Tešević, Vele
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/285
AB  - In continuation of our phytochemical survey of Lobaria pulmonaria has led to the identification of deoxystictic acid in this foliose lichen species for the first time. The isolated β-orcinol depsidone showed moderate anti-hydroxyl radical activity using fluorescence spectroscopy at in vitro conditions. Phytochemistry Aromatic secondary metabolite Anti-hydroxyl radical activity. This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Research grant No. 172053). The assistance of Mr. V. Mirra (CNR-ICB, Pozzuoli-Naples, Italy) is gratefully acknowledged.
T2  - Asian Journal of Chemistry
T1  - A novel β-orcinol depsidone of lichen lobaria pulmonaria
VL  - 26
IS  - 23
SP  - 8257
EP  - 8258
DO  - 10.14233/ajchem.2014.17834
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Stanimirović, Bojana and Vajs, Vlatka and Tešević, Vele",
year = "2014",
abstract = "In continuation of our phytochemical survey of Lobaria pulmonaria has led to the identification of deoxystictic acid in this foliose lichen species for the first time. The isolated β-orcinol depsidone showed moderate anti-hydroxyl radical activity using fluorescence spectroscopy at in vitro conditions. Phytochemistry Aromatic secondary metabolite Anti-hydroxyl radical activity. This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Research grant No. 172053). The assistance of Mr. V. Mirra (CNR-ICB, Pozzuoli-Naples, Italy) is gratefully acknowledged.",
journal = "Asian Journal of Chemistry",
title = "A novel β-orcinol depsidone of lichen lobaria pulmonaria",
volume = "26",
number = "23",
pages = "8257-8258",
doi = "10.14233/ajchem.2014.17834"
}

Pejin, B., Iodice, C., Stanimirović, B., Vajs, V.,& Tešević, V.. (2014). A novel β-orcinol depsidone of lichen lobaria pulmonaria. in Asian Journal of Chemistry, 26(23), 8257-8258.
https://doi.org/10.14233/ajchem.2014.17834

Pejin B, Iodice C, Stanimirović B, Vajs V, Tešević V. A novel β-orcinol depsidone of lichen lobaria pulmonaria. in Asian Journal of Chemistry. 2014;26(23):8257-8258.
doi:10.14233/ajchem.2014.17834 .

Pejin, Boris, Iodice, Carmine, Stanimirović, Bojana, Vajs, Vlatka, Tešević, Vele, "A novel β-orcinol depsidone of lichen lobaria pulmonaria" in Asian Journal of Chemistry, 26, no. 23 (2014):8257-8258,
https://doi.org/10.14233/ajchem.2014.17834 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - De Rosa, Salvatore
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1373
AB  - The phytochemical investigation conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), led to the isolation of a new depsidone in the form of its diacetate derivative which showed a moderate acetylcholinesterase inhibition activity (1 mu g) in vitro. This is the first record of identified depsidone structure in searching for these inhibitors.
PB  - Informa Healthcare, London
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity
VL  - 28
IS  - 4
SP  - 876
EP  - 878
DO  - 10.3109/14756366.2012.677839
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka and De Rosa, Salvatore",
year = "2013",
abstract = "The phytochemical investigation conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), led to the isolation of a new depsidone in the form of its diacetate derivative which showed a moderate acetylcholinesterase inhibition activity (1 mu g) in vitro. This is the first record of identified depsidone structure in searching for these inhibitors.",
publisher = "Informa Healthcare, London",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity",
volume = "28",
number = "4",
pages = "876-878",
doi = "10.3109/14756366.2012.677839"
}

Pejin, B., Tommonaro, G., Iodice, C., Tešević, V., Vajs, V.,& De Rosa, S.. (2013). A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity. in Journal of Enzyme Inhibition and Medicinal Chemistry
Informa Healthcare, London., 28(4), 876-878.
https://doi.org/10.3109/14756366.2012.677839

Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs V, De Rosa S. A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2013;28(4):876-878.
doi:10.3109/14756366.2012.677839 .

Pejin, Boris, Tommonaro, Giuseppina, Iodice, Carmine, Tešević, Vele, Vajs, Vlatka, De Rosa, Salvatore, "A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity" in Journal of Enzyme Inhibition and Medicinal Chemistry, 28, no. 4 (2013):876-878,
https://doi.org/10.3109/14756366.2012.677839 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - Sabovljević, Marko
AU  - Bianco, Armandodoriano
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - De Rosa, Salvatore
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1272
AB  - Although the second biggest terrestrial group of plants, bryophytes remain poorly known chemically compared to the angiosperms. In this article, the sugars of the moss Rhodobryum ontariense, an unstudied representative of the medicinally known genus, are reported. The chemical analysis revealed the usual plant sugar sucrose, and a new sugar, fructooligosaccharide 1-kestose, which is reported first not only for the genus Rhodobryum, but also for mosses. The trisaccharides have been scantily reported in bryophytes hitherto. This gives more significance to this study for further investigation of its role in the moss species. The health-promoting effect of 1-kestose is also briefly discussed.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.
VL  - 26
IS  - 3
SP  - 209
EP  - 215
DO  - 10.1080/14786419.2010.535163
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and Sabovljević, Marko and Bianco, Armandodoriano and Tešević, Vele and Vajs, Vlatka and De Rosa, Salvatore",
year = "2012",
abstract = "Although the second biggest terrestrial group of plants, bryophytes remain poorly known chemically compared to the angiosperms. In this article, the sugars of the moss Rhodobryum ontariense, an unstudied representative of the medicinally known genus, are reported. The chemical analysis revealed the usual plant sugar sucrose, and a new sugar, fructooligosaccharide 1-kestose, which is reported first not only for the genus Rhodobryum, but also for mosses. The trisaccharides have been scantily reported in bryophytes hitherto. This gives more significance to this study for further investigation of its role in the moss species. The health-promoting effect of 1-kestose is also briefly discussed.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.",
volume = "26",
number = "3",
pages = "209-215",
doi = "10.1080/14786419.2010.535163"
}

Pejin, B., Iodice, C., Tommonaro, G., Sabovljević, M., Bianco, A., Tešević, V., Vajs, V.,& De Rosa, S.. (2012). Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 26(3), 209-215.
https://doi.org/10.1080/14786419.2010.535163

Pejin B, Iodice C, Tommonaro G, Sabovljević M, Bianco A, Tešević V, Vajs V, De Rosa S. Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb.. in Natural Product Research. 2012;26(3):209-215.
doi:10.1080/14786419.2010.535163 .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, Sabovljević, Marko, Bianco, Armandodoriano, Tešević, Vele, Vajs, Vlatka, De Rosa, Salvatore, "Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb." in Natural Product Research, 26, no. 3 (2012):209-215,
https://doi.org/10.1080/14786419.2010.535163 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Tešević, Vele
AU  - Vajs, Vlatka
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1323
AB  - As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria
VL  - 26
IS  - 17
SP  - 1634
EP  - 1637
DO  - 10.1080/14786419.2011.585989
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka",
year = "2012",
abstract = "As part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria",
volume = "26",
number = "17",
pages = "1634-1637",
doi = "10.1080/14786419.2011.585989"
}

Pejin, B., Tommonaro, G., Iodice, C., Tešević, V.,& Vajs, V.. (2012). Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 26(17), 1634-1637.
https://doi.org/10.1080/14786419.2011.585989

Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs V. Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria. in Natural Product Research. 2012;26(17):1634-1637.
doi:10.1080/14786419.2011.585989 .

Pejin, Boris, Tommonaro, Giuseppina, Iodice, Carmine, Tešević, Vele, Vajs, Vlatka, "Acetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonaria" in Natural Product Research, 26, no. 17 (2012):1634-1637,
https://doi.org/10.1080/14786419.2011.585989 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, G.
AU  - Iodice, Carmine
AU  - Tešević, Vele
AU  - Vajs, Vlatka
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1306
AB  - A phytochemical investigation conducted on a folise lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina led to a mixture of methylated depsidones which showed acetylcholinesterase inhibition activity (2 mu g) in the acetylcholinesterase inhibition test on thin-layer chromatography plate. Present results indicate for the first time the potential of methylated depsidones in searching for these inhibitors, which still represent the best drugs currently available for the management of Alzheimer's disease.
PB  - Asian Journal Of Chemistry, Sahibabad
T2  - Asian Journal of Chemistry
T1  - Acetylcholinesterase Inhibition Activity of a Mixture of Methylated Depsidones from the Lichen Lobaria pulmonaria
VL  - 24
IS  - 7
SP  - 3261
EP  - 3262
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1306
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, G. and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka",
year = "2012",
abstract = "A phytochemical investigation conducted on a folise lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina led to a mixture of methylated depsidones which showed acetylcholinesterase inhibition activity (2 mu g) in the acetylcholinesterase inhibition test on thin-layer chromatography plate. Present results indicate for the first time the potential of methylated depsidones in searching for these inhibitors, which still represent the best drugs currently available for the management of Alzheimer's disease.",
publisher = "Asian Journal Of Chemistry, Sahibabad",
journal = "Asian Journal of Chemistry",
title = "Acetylcholinesterase Inhibition Activity of a Mixture of Methylated Depsidones from the Lichen Lobaria pulmonaria",
volume = "24",
number = "7",
pages = "3261-3262",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1306"
}

Pejin, B., Tommonaro, G., Iodice, C., Tešević, V.,& Vajs, V.. (2012). Acetylcholinesterase Inhibition Activity of a Mixture of Methylated Depsidones from the Lichen Lobaria pulmonaria. in Asian Journal of Chemistry
Asian Journal Of Chemistry, Sahibabad., 24(7), 3261-3262.
https://hdl.handle.net/21.15107/rcub_cherry_1306

Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs V. Acetylcholinesterase Inhibition Activity of a Mixture of Methylated Depsidones from the Lichen Lobaria pulmonaria. in Asian Journal of Chemistry. 2012;24(7):3261-3262.
https://hdl.handle.net/21.15107/rcub_cherry_1306 .

Pejin, Boris, Tommonaro, G., Iodice, Carmine, Tešević, Vele, Vajs, Vlatka, "Acetylcholinesterase Inhibition Activity of a Mixture of Methylated Depsidones from the Lichen Lobaria pulmonaria" in Asian Journal of Chemistry, 24, no. 7 (2012):3261-3262,
https://hdl.handle.net/21.15107/rcub_cherry_1306 .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Iodice, Carmine
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - De Rosa, Salvatore
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1566
AB  - The continuation of our phytochemical survey of Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), has led to the isolation and identification of a new lichen depsidone (1) characterised by the normal analytical and spectroscopic techniques. Unlike previously isolated depsidone (2) from the same species, the compound 1 has not showed activity in the acetylcholinesterase inhibition test on Thin-layer chromatography plate.
PB  - Inst Materials Physics, Bucharest
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - A New Lichen Depsidone from  L Obaria Pulmonaria
VL  - 7
IS  - 4
SP  - 1663
EP  - 1666
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1566
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Iodice, Carmine and Tešević, Vele and Vajs, Vlatka and De Rosa, Salvatore",
year = "2012",
abstract = "The continuation of our phytochemical survey of Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), has led to the isolation and identification of a new lichen depsidone (1) characterised by the normal analytical and spectroscopic techniques. Unlike previously isolated depsidone (2) from the same species, the compound 1 has not showed activity in the acetylcholinesterase inhibition test on Thin-layer chromatography plate.",
publisher = "Inst Materials Physics, Bucharest",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "A New Lichen Depsidone from  L Obaria Pulmonaria",
volume = "7",
number = "4",
pages = "1663-1666",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1566"
}

Pejin, B., Tommonaro, G., Iodice, C., Tešević, V., Vajs, V.,& De Rosa, S.. (2012). A New Lichen Depsidone from  L Obaria Pulmonaria. in Digest Journal of Nanomaterials and Biostructures
Inst Materials Physics, Bucharest., 7(4), 1663-1666.
https://hdl.handle.net/21.15107/rcub_cherry_1566

Pejin B, Tommonaro G, Iodice C, Tešević V, Vajs V, De Rosa S. A New Lichen Depsidone from  L Obaria Pulmonaria. in Digest Journal of Nanomaterials and Biostructures. 2012;7(4):1663-1666.
https://hdl.handle.net/21.15107/rcub_cherry_1566 .

Pejin, Boris, Tommonaro, Giuseppina, Iodice, Carmine, Tešević, Vele, Vajs, Vlatka, De Rosa, Salvatore, "A New Lichen Depsidone from  L Obaria Pulmonaria" in Digest Journal of Nanomaterials and Biostructures, 7, no. 4 (2012):1663-1666,
https://hdl.handle.net/21.15107/rcub_cherry_1566 .