TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Jagodić, Jovana
AU  - Miković, Željko
AU  - Jeremić, Ana
AU  - Perović, Milan
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5320
AB  - Due to the recognized harmful effects of some trace elements on fetal development after long-term exposures, it is first important to address their basic/physiological levels before monitoring toxicological effects and clinical outcomes on prenatal and postnatal health. This research aimed to define, for the first time, reference values for multiple (ultra) trace elements in umbilical cord blood (UCB) plasma samples of a notable number of healthy pregnant women (n = 125). All samples were collected during 2020–2021 and all participants were from Belgrade and two regions (Šumadija and Podunavlje). Following trace elements were enrolled in this study: essential (Mn, Co, Cu, Zn, Se, Mo), toxic (Be, Al, Ni, As, Rb, Sr, Ag, Cd, Sb, Ba, Tl, Pb, Th, U), rare earth (La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm), and noble metals (Ru, Rh, Pd, Re, Ir, Os, Pt). UCB plasma samples were diluted with suitable solvents and analyzed by inductively coupled plasma-mass spectrometry. The analytical technique used was validated by the standard addition method and using certified reference materials. Zn was found in the highest amount and Tm in the least amount. Be, Co, Ag, Sb, La, and Ce exhibited statistically significant differences in the four age groups (20 to 41 years), whereas Ag and Ce showed a tendency to increase with age. Furthermore, our participants had notably higher As, Ni, and Co, levels and lower Zn levels compared to other populations. This is the first study that, in addition to analyzing essential and toxic trace elements, also provided an analysis of noble and rare earth elements in UCB plasma samples. Presented results can be used as a starting point or database for further studies, in terms of predicting the pregnancy outcome and postnatal development.
PB  - SpringerLink
T2  - Exposure and Health
T1  - Evaluation of Maternal Exposure to Multiple Trace Elements and Their Detection in Umbilical Cord Blood
VL  - 14
IS  - 3
SP  - 623
EP  - 633
DO  - 10.1007/s12403-021-00441-5
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Jagodić, Jovana and Miković, Željko and Jeremić, Ana and Perović, Milan and Manojlović, Dragan D.",
year = "2022",
abstract = "Due to the recognized harmful effects of some trace elements on fetal development after long-term exposures, it is first important to address their basic/physiological levels before monitoring toxicological effects and clinical outcomes on prenatal and postnatal health. This research aimed to define, for the first time, reference values for multiple (ultra) trace elements in umbilical cord blood (UCB) plasma samples of a notable number of healthy pregnant women (n = 125). All samples were collected during 2020–2021 and all participants were from Belgrade and two regions (Šumadija and Podunavlje). Following trace elements were enrolled in this study: essential (Mn, Co, Cu, Zn, Se, Mo), toxic (Be, Al, Ni, As, Rb, Sr, Ag, Cd, Sb, Ba, Tl, Pb, Th, U), rare earth (La, Ce, Pr, Nd, Sm, Eu, Gd, Dy, Ho, Er, Tm), and noble metals (Ru, Rh, Pd, Re, Ir, Os, Pt). UCB plasma samples were diluted with suitable solvents and analyzed by inductively coupled plasma-mass spectrometry. The analytical technique used was validated by the standard addition method and using certified reference materials. Zn was found in the highest amount and Tm in the least amount. Be, Co, Ag, Sb, La, and Ce exhibited statistically significant differences in the four age groups (20 to 41 years), whereas Ag and Ce showed a tendency to increase with age. Furthermore, our participants had notably higher As, Ni, and Co, levels and lower Zn levels compared to other populations. This is the first study that, in addition to analyzing essential and toxic trace elements, also provided an analysis of noble and rare earth elements in UCB plasma samples. Presented results can be used as a starting point or database for further studies, in terms of predicting the pregnancy outcome and postnatal development.",
publisher = "SpringerLink",
journal = "Exposure and Health",
title = "Evaluation of Maternal Exposure to Multiple Trace Elements and Their Detection in Umbilical Cord Blood",
volume = "14",
number = "3",
pages = "623-633",
doi = "10.1007/s12403-021-00441-5"
}

Stojsavljević, A., Rovčanin, M., Jagodić, J., Miković, Ž., Jeremić, A., Perović, M.,& Manojlović, D. D.. (2022). Evaluation of Maternal Exposure to Multiple Trace Elements and Their Detection in Umbilical Cord Blood. in Exposure and Health
SpringerLink., 14(3), 623-633.
https://doi.org/10.1007/s12403-021-00441-5

Stojsavljević A, Rovčanin M, Jagodić J, Miković Ž, Jeremić A, Perović M, Manojlović DD. Evaluation of Maternal Exposure to Multiple Trace Elements and Their Detection in Umbilical Cord Blood. in Exposure and Health. 2022;14(3):623-633.
doi:10.1007/s12403-021-00441-5 .

Stojsavljević, Aleksandar, Rovčanin, Marija, Jagodić, Jovana, Miković, Željko, Jeremić, Ana, Perović, Milan, Manojlović, Dragan D., "Evaluation of Maternal Exposure to Multiple Trace Elements and Their Detection in Umbilical Cord Blood" in Exposure and Health, 14, no. 3 (2022):623-633,
https://doi.org/10.1007/s12403-021-00441-5 . .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Miković, Željko
AU  - Perović, Milan
AU  - Jeremić, Ana
AU  - Zečević, Nebojša
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4879
AB  - Progressive industrialization in recent decades has contributed to the increase of metal levels in the environment, which has a dangerous impact on human health, primarily pregnant women. In this study, we aimed to compare levels of various elements in maternal and umbilical cord (UC) plasma samples collected from 125 healthy pregnant women, conduct correlation analysis among paired plasma samples, and compare our data with other populations worldwide. The study design included the following elements: essential (Mn, Co, Cu, Zn, Se, Mo), non-essential (Be, Al, Ni, As, Rb, Sr, Cd, Sb, Pb, U), rare earth (La, Pr, Ce, Nd, Sm, Eu, Gd, Dy, Ho, Er), and noble metals (Ru, Rh, Re, Pt). Levels of 30 elements were higher in maternal plasma than in UC plasma samples. However, no disparities at the statistically significant level were found for Be, Zn, Rb, Cd, Ce, and Ho. Correlation analysis among paired plasma samples revealed only positive/synergistic correlations of different strengths between most elements. Compared to other countries across the globe, our participants had considerably lower plasma levels of Zn and higher levels of Co, Ni, and As. This study provides not only a new and deeper comprehension, but also the first insight into the levels, correlation, distribution, and potential transplacental transfer of 30 elements.
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood
VL  - 29
SP  - 37375
EP  - 37383
DO  - 10.1007/s11356-021-18190-y
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Miković, Željko and Perović, Milan and Jeremić, Ana and Zečević, Nebojša and Manojlović, Dragan D.",
year = "2022",
abstract = "Progressive industrialization in recent decades has contributed to the increase of metal levels in the environment, which has a dangerous impact on human health, primarily pregnant women. In this study, we aimed to compare levels of various elements in maternal and umbilical cord (UC) plasma samples collected from 125 healthy pregnant women, conduct correlation analysis among paired plasma samples, and compare our data with other populations worldwide. The study design included the following elements: essential (Mn, Co, Cu, Zn, Se, Mo), non-essential (Be, Al, Ni, As, Rb, Sr, Cd, Sb, Pb, U), rare earth (La, Pr, Ce, Nd, Sm, Eu, Gd, Dy, Ho, Er), and noble metals (Ru, Rh, Re, Pt). Levels of 30 elements were higher in maternal plasma than in UC plasma samples. However, no disparities at the statistically significant level were found for Be, Zn, Rb, Cd, Ce, and Ho. Correlation analysis among paired plasma samples revealed only positive/synergistic correlations of different strengths between most elements. Compared to other countries across the globe, our participants had considerably lower plasma levels of Zn and higher levels of Co, Ni, and As. This study provides not only a new and deeper comprehension, but also the first insight into the levels, correlation, distribution, and potential transplacental transfer of 30 elements.",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood",
volume = "29",
pages = "37375-37383",
doi = "10.1007/s11356-021-18190-y"
}

Stojsavljević, A., Rovčanin, M., Miković, Ž., Perović, M., Jeremić, A., Zečević, N.,& Manojlović, D. D.. (2022). Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood. in Environmental Science and Pollution Research
Springer., 29, 37375-37383.
https://doi.org/10.1007/s11356-021-18190-y

Stojsavljević A, Rovčanin M, Miković Ž, Perović M, Jeremić A, Zečević N, Manojlović DD. Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood. in Environmental Science and Pollution Research. 2022;29:37375-37383.
doi:10.1007/s11356-021-18190-y .

Stojsavljević, Aleksandar, Rovčanin, Marija, Miković, Željko, Perović, Milan, Jeremić, Ana, Zečević, Nebojša, Manojlović, Dragan D., "Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood" in Environmental Science and Pollution Research, 29 (2022):37375-37383,
https://doi.org/10.1007/s11356-021-18190-y . .

TY  - DATA
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Miković, Željko
AU  - Perović, Milan
AU  - Jeremić, Ana
AU  - Zečević, Nebojša
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4880
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4880
ER  - 

@misc{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Miković, Željko and Perović, Milan and Jeremić, Ana and Zečević, Nebojša and Manojlović, Dragan D.",
year = "2022",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4880"
}

Stojsavljević, A., Rovčanin, M., Miković, Ž., Perović, M., Jeremić, A., Zečević, N.,& Manojlović, D. D.. (2022). Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.. in Environmental Science and Pollution Research
Springer..
https://hdl.handle.net/21.15107/rcub_cherry_4880

Stojsavljević A, Rovčanin M, Miković Ž, Perović M, Jeremić A, Zečević N, Manojlović DD. Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.. in Environmental Science and Pollution Research. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_4880 .

Stojsavljević, Aleksandar, Rovčanin, Marija, Miković, Željko, Perović, Milan, Jeremić, Ana, Zečević, Nebojša, Manojlović, Dragan D., "Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y." in Environmental Science and Pollution Research (2022),
https://hdl.handle.net/21.15107/rcub_cherry_4880 .

TY  - DATA
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Rovčanin, Branislav
AU  - Miković, Željko
AU  - Jeremić, Ana
AU  - Perović, Milan
AU  - Manojlović, Dragan D.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4806
PB  - Elsevier
T2  - Chemosphere
T1  - Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Rovčanin, B.; Miković, Ž.; Jeremić, A.; Perović, M.; Manojlović, D. Human Biomonitoring of Essential, Nonessential, Rare Earth, and Noble Elements in Placental Tissues. Chemosphere 2021, 285, 131518. https://doi.org/10.1016/j.chemosphere.2021.131518.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4806
ER  - 

@misc{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Rovčanin, Branislav and Miković, Željko and Jeremić, Ana and Perović, Milan and Manojlović, Dragan D.",
year = "2021",
publisher = "Elsevier",
journal = "Chemosphere",
title = "Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Rovčanin, B.; Miković, Ž.; Jeremić, A.; Perović, M.; Manojlović, D. Human Biomonitoring of Essential, Nonessential, Rare Earth, and Noble Elements in Placental Tissues. Chemosphere 2021, 285, 131518. https://doi.org/10.1016/j.chemosphere.2021.131518.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4806"
}

Stojsavljević, A., Rovčanin, M., Rovčanin, B., Miković, Ž., Jeremić, A., Perović, M.,& Manojlović, D. D.. (2021). Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Rovčanin, B.; Miković, Ž.; Jeremić, A.; Perović, M.; Manojlović, D. Human Biomonitoring of Essential, Nonessential, Rare Earth, and Noble Elements in Placental Tissues. Chemosphere 2021, 285, 131518. https://doi.org/10.1016/j.chemosphere.2021.131518.. in Chemosphere
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4806

Stojsavljević A, Rovčanin M, Rovčanin B, Miković Ž, Jeremić A, Perović M, Manojlović DD. Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Rovčanin, B.; Miković, Ž.; Jeremić, A.; Perović, M.; Manojlović, D. Human Biomonitoring of Essential, Nonessential, Rare Earth, and Noble Elements in Placental Tissues. Chemosphere 2021, 285, 131518. https://doi.org/10.1016/j.chemosphere.2021.131518.. in Chemosphere. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4806 .

Stojsavljević, Aleksandar, Rovčanin, Marija, Rovčanin, Branislav, Miković, Željko, Jeremić, Ana, Perović, Milan, Manojlović, Dragan D., "Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Rovčanin, B.; Miković, Ž.; Jeremić, A.; Perović, M.; Manojlović, D. Human Biomonitoring of Essential, Nonessential, Rare Earth, and Noble Elements in Placental Tissues. Chemosphere 2021, 285, 131518. https://doi.org/10.1016/j.chemosphere.2021.131518." in Chemosphere (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4806 .

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Rovčanin, Branislav
AU  - Miković, Željko
AU  - Jeremić, Ana
AU  - Perović, Milan
AU  - Manojlović, Dragan D.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4805
AB  - Exposure to certain metals has been recognized as a risk factor for numerous complications in vulnerable population groups, particularly pregnant women. This investigation evaluated the levels of essential (Cr, Mn, Co, Cu, Zn, Se, Mo) and nonessential trace metals with recognized toxicity (Be, Al, Ti, V, Ni, Ga, As, Rb, Sr, Cd, Sb, Ba, Tl, Hg, Pb, Bi, Th, U), together with rare earth elements (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb, Lu), and noble metals (Ru, Rh, Pd, Re, Os, Ir, Pt, Au, Ag) in the placental tissues of healthy pregnant women (n = 105). The selection of participants was undertaken with special reference to specific confounding factors that could influence the trace element profiles. Among trace elements, Zn was the most abundant and Lu was the least abundant. Cd and Os placental levels show a tendency to increase with women's age. Compared with literature data, high levels of Ni were found. This is the first study that provides the composition levels of essential and toxic trace elements, rare earth elements, and noble metals in human placental tissues. Also, for the first time, normal (reference) ranges for 50 (ultra)trace elements in placental tissues are proposed. Reference ranges are especially important in biomonitoring studies, which nowadays give increasing importance to the analysis of solid tissues instead of body fluids. Overall, the information provided in this study can serve as a starting point for further clinical trials and/or prediction of potential risks to pregnancy.
PB  - Elsevier
T2  - Chemosphere
T1  - Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues
VL  - 285
SP  - 131518
DO  - 10.1016/j.chemosphere.2021.131518
ER  - 

@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Rovčanin, Branislav and Miković, Željko and Jeremić, Ana and Perović, Milan and Manojlović, Dragan D.",
year = "2021",
abstract = "Exposure to certain metals has been recognized as a risk factor for numerous complications in vulnerable population groups, particularly pregnant women. This investigation evaluated the levels of essential (Cr, Mn, Co, Cu, Zn, Se, Mo) and nonessential trace metals with recognized toxicity (Be, Al, Ti, V, Ni, Ga, As, Rb, Sr, Cd, Sb, Ba, Tl, Hg, Pb, Bi, Th, U), together with rare earth elements (Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb, Lu), and noble metals (Ru, Rh, Pd, Re, Os, Ir, Pt, Au, Ag) in the placental tissues of healthy pregnant women (n = 105). The selection of participants was undertaken with special reference to specific confounding factors that could influence the trace element profiles. Among trace elements, Zn was the most abundant and Lu was the least abundant. Cd and Os placental levels show a tendency to increase with women's age. Compared with literature data, high levels of Ni were found. This is the first study that provides the composition levels of essential and toxic trace elements, rare earth elements, and noble metals in human placental tissues. Also, for the first time, normal (reference) ranges for 50 (ultra)trace elements in placental tissues are proposed. Reference ranges are especially important in biomonitoring studies, which nowadays give increasing importance to the analysis of solid tissues instead of body fluids. Overall, the information provided in this study can serve as a starting point for further clinical trials and/or prediction of potential risks to pregnancy.",
publisher = "Elsevier",
journal = "Chemosphere",
title = "Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues",
volume = "285",
pages = "131518",
doi = "10.1016/j.chemosphere.2021.131518"
}

Stojsavljević, A., Rovčanin, M., Rovčanin, B., Miković, Ž., Jeremić, A., Perović, M.,& Manojlović, D. D.. (2021). Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues. in Chemosphere
Elsevier., 285, 131518.
https://doi.org/10.1016/j.chemosphere.2021.131518

Stojsavljević A, Rovčanin M, Rovčanin B, Miković Ž, Jeremić A, Perović M, Manojlović DD. Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues. in Chemosphere. 2021;285:131518.
doi:10.1016/j.chemosphere.2021.131518 .

Stojsavljević, Aleksandar, Rovčanin, Marija, Rovčanin, Branislav, Miković, Željko, Jeremić, Ana, Perović, Milan, Manojlović, Dragan D., "Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues" in Chemosphere, 285 (2021):131518,
https://doi.org/10.1016/j.chemosphere.2021.131518 . .