TY  - JOUR
AU  - Kolarević, Stoimir
AU  - Milovanović, D.
AU  - Kračun-Kolarević, M.
AU  - Kostić, J.
AU  - Sunjog, K.
AU  - Martinović, R.
AU  - Popović-Đorđević, Jelena
AU  - Novaković, Irena T.
AU  - Sladić, Dušan
AU  - Vuković-Gačić, Branka
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/322
AB  - In this study, mutagenic and genotoxic potential of anti-tumor compounds avarol, avarone, and its derivatives 3′-methoxyavarone, 4′-(methylamino)avarone and 3′-(methylamino)avarone was evaluated and compared to cytostatics commonly used in chemotherapy (5-fluorouracil, etoposid, and cisplatin). Mutagenic potential of selected hydroquinone and quinones was assessed in prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002. Genotoxic potential was also assessed in eukaryotic models using comet assay in human fetal lung cell line (MRC-5), human adenocarcinoma epithelial cell line (A549), and in human peripheral blood cells (HPBC). The results indicated that avarol and avarone do not exert mutagenic/genotoxic potential. Among the studied avarone derivatives, mutagenic potential was detected by SOS/umuC test for 3′-(methylamino)avarone, but only after metabolic activation. The results of comet assay indicated that 3′-methoxyavarone and 3′-(methylamino)avarone have a significant impact on the level of DNA damage in the MRC-5 cell line. Genotoxic potential was not observed in A549 cells or HPBC probably due to a different uptake rate for the compounds and lower in metabolism rate within these cells.
PB  - Taylor & Francis Ltd
T2  - Drug and Chemical Toxicology
T1  - Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models
SP  - 1
EP  - 10
DO  - 10.1080/01480545.2017.1413108
ER  - 

@article{
author = "Kolarević, Stoimir and Milovanović, D. and Kračun-Kolarević, M. and Kostić, J. and Sunjog, K. and Martinović, R. and Popović-Đorđević, Jelena and Novaković, Irena T. and Sladić, Dušan and Vuković-Gačić, Branka",
year = "2017",
abstract = "In this study, mutagenic and genotoxic potential of anti-tumor compounds avarol, avarone, and its derivatives 3′-methoxyavarone, 4′-(methylamino)avarone and 3′-(methylamino)avarone was evaluated and compared to cytostatics commonly used in chemotherapy (5-fluorouracil, etoposid, and cisplatin). Mutagenic potential of selected hydroquinone and quinones was assessed in prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002. Genotoxic potential was also assessed in eukaryotic models using comet assay in human fetal lung cell line (MRC-5), human adenocarcinoma epithelial cell line (A549), and in human peripheral blood cells (HPBC). The results indicated that avarol and avarone do not exert mutagenic/genotoxic potential. Among the studied avarone derivatives, mutagenic potential was detected by SOS/umuC test for 3′-(methylamino)avarone, but only after metabolic activation. The results of comet assay indicated that 3′-methoxyavarone and 3′-(methylamino)avarone have a significant impact on the level of DNA damage in the MRC-5 cell line. Genotoxic potential was not observed in A549 cells or HPBC probably due to a different uptake rate for the compounds and lower in metabolism rate within these cells.",
publisher = "Taylor & Francis Ltd",
journal = "Drug and Chemical Toxicology",
title = "Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models",
pages = "1-10",
doi = "10.1080/01480545.2017.1413108"
}

Kolarević, S., Milovanović, D., Kračun-Kolarević, M., Kostić, J., Sunjog, K., Martinović, R., Popović-Đorđević, J., Novaković, I. T., Sladić, D.,& Vuković-Gačić, B.. (2017). Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models. in Drug and Chemical Toxicology
Taylor & Francis Ltd., 1-10.
https://doi.org/10.1080/01480545.2017.1413108

Kolarević S, Milovanović D, Kračun-Kolarević M, Kostić J, Sunjog K, Martinović R, Popović-Đorđević J, Novaković IT, Sladić D, Vuković-Gačić B. Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models. in Drug and Chemical Toxicology. 2017;:1-10.
doi:10.1080/01480545.2017.1413108 .

Kolarević, Stoimir, Milovanović, D., Kračun-Kolarević, M., Kostić, J., Sunjog, K., Martinović, R., Popović-Đorđević, Jelena, Novaković, Irena T., Sladić, Dušan, Vuković-Gačić, Branka, "Evaluation of genotoxic potential of avarol, avarone, and its methoxy and methylamino derivatives in prokaryotic and eukaryotic test models" in Drug and Chemical Toxicology (2017):1-10,
https://doi.org/10.1080/01480545.2017.1413108 . .

TY  - DATA
AU  - Kolarević, Stoimir
AU  - Milovanović, D.
AU  - Kračun-Kolarević, M.
AU  - Kostić, J.
AU  - Sunjog, K.
AU  - Martinović, R.
AU  - Popović-Đorđević, Jelena
AU  - Novaković, Irena T.
AU  - Sladić, Dušan
AU  - Vuković-Gačić, Branka
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3033
PB  - Taylor & Francis Ltd
T2  - Drug and Chemical Toxicology
T1  - Supplementary data for article : Kolarević, S.; Milovanović, D.; Kračun-Kolarević, M.; Kostić, J.; Sunjog, K.; Martinović, R.; Đorđević, J.; Novaković, I.; Sladić, D.; Vuković-Gačić, B. Evaluation of Genotoxic Potential of Avarol, Avarone, and Its Methoxy and Methylamino Derivatives in Prokaryotic and Eukaryotic Test Models. Drug and Chemical Toxicology 2019, 42 (2), 130–139. https://doi.org/10.1080/01480545.2017.1413108
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3033
ER  - 

@misc{
author = "Kolarević, Stoimir and Milovanović, D. and Kračun-Kolarević, M. and Kostić, J. and Sunjog, K. and Martinović, R. and Popović-Đorđević, Jelena and Novaković, Irena T. and Sladić, Dušan and Vuković-Gačić, Branka",
year = "2017",
publisher = "Taylor & Francis Ltd",
journal = "Drug and Chemical Toxicology",
title = "Supplementary data for article : Kolarević, S.; Milovanović, D.; Kračun-Kolarević, M.; Kostić, J.; Sunjog, K.; Martinović, R.; Đorđević, J.; Novaković, I.; Sladić, D.; Vuković-Gačić, B. Evaluation of Genotoxic Potential of Avarol, Avarone, and Its Methoxy and Methylamino Derivatives in Prokaryotic and Eukaryotic Test Models. Drug and Chemical Toxicology 2019, 42 (2), 130–139. https://doi.org/10.1080/01480545.2017.1413108",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3033"
}

Kolarević, S., Milovanović, D., Kračun-Kolarević, M., Kostić, J., Sunjog, K., Martinović, R., Popović-Đorđević, J., Novaković, I. T., Sladić, D.,& Vuković-Gačić, B.. (2017). Supplementary data for article : Kolarević, S.; Milovanović, D.; Kračun-Kolarević, M.; Kostić, J.; Sunjog, K.; Martinović, R.; Đorđević, J.; Novaković, I.; Sladić, D.; Vuković-Gačić, B. Evaluation of Genotoxic Potential of Avarol, Avarone, and Its Methoxy and Methylamino Derivatives in Prokaryotic and Eukaryotic Test Models. Drug and Chemical Toxicology 2019, 42 (2), 130–139. https://doi.org/10.1080/01480545.2017.1413108. in Drug and Chemical Toxicology
Taylor & Francis Ltd..
https://hdl.handle.net/21.15107/rcub_cherry_3033

Kolarević S, Milovanović D, Kračun-Kolarević M, Kostić J, Sunjog K, Martinović R, Popović-Đorđević J, Novaković IT, Sladić D, Vuković-Gačić B. Supplementary data for article : Kolarević, S.; Milovanović, D.; Kračun-Kolarević, M.; Kostić, J.; Sunjog, K.; Martinović, R.; Đorđević, J.; Novaković, I.; Sladić, D.; Vuković-Gačić, B. Evaluation of Genotoxic Potential of Avarol, Avarone, and Its Methoxy and Methylamino Derivatives in Prokaryotic and Eukaryotic Test Models. Drug and Chemical Toxicology 2019, 42 (2), 130–139. https://doi.org/10.1080/01480545.2017.1413108. in Drug and Chemical Toxicology. 2017;.
https://hdl.handle.net/21.15107/rcub_cherry_3033 .

Kolarević, Stoimir, Milovanović, D., Kračun-Kolarević, M., Kostić, J., Sunjog, K., Martinović, R., Popović-Đorđević, Jelena, Novaković, Irena T., Sladić, Dušan, Vuković-Gačić, Branka, "Supplementary data for article : Kolarević, S.; Milovanović, D.; Kračun-Kolarević, M.; Kostić, J.; Sunjog, K.; Martinović, R.; Đorđević, J.; Novaković, I.; Sladić, D.; Vuković-Gačić, B. Evaluation of Genotoxic Potential of Avarol, Avarone, and Its Methoxy and Methylamino Derivatives in Prokaryotic and Eukaryotic Test Models. Drug and Chemical Toxicology 2019, 42 (2), 130–139. https://doi.org/10.1080/01480545.2017.1413108" in Drug and Chemical Toxicology (2017),
https://hdl.handle.net/21.15107/rcub_cherry_3033 .