Lević, Steva M.

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Authority KeyName Variants
fb252d80-3f10-4551-a06c-a3a794fe1798
  • Lević, Steva M. (12)
  • Lević, Steva (1)
Projects
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200116 (University of Belgrade, Faculty of Agriculture) Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology
Structural characterisation of the insulin-like growth factor (IGF) binding proteins and IGF receptors, their interactions with other physiological molecules and alterations in metabolic disorders Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković')
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200042 (University of Belgrade, Institute of Molecular Genetics and Genetic Engineering)
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200135 (University of Belgrade, Faculty of Technology and Metallurgy) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200168 (University of Belgrade, Faculty of Chemistry)
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200288 (Innovation Center of the Faculty of Chemistry) Belgian Special Research Fund BOF STG, grant number 01N01718.
FoodEnTwin-Twinning of research activities for the frontier research in the fields of food, nutrition and environmental omics Structure-properties relationships of natural and synthetic molecules and their metal complexes
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200019 (University of Belgrade, Institute for the Application of Nuclear Energy - INEP) Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200175 (Institute of Technical Sciences of SASA, Belgrade)
Develooment and utilization of novel and traditional technologies in production of competitive food products with added valued for national and global market - CREATING WEALTH FROM THE WEALTH OF SERBIA Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market
Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness Utilization of plant sources of protein, dietary fiber and antioxidants in food production
Serbian Academy of Sciences and Arts, grant number F-26.

Author's Bibliography

Challenges and potential for detecting and quantifying titanium dioxide in food

Đekić, Ilija; Lević, Steva; Šmigić, Nada; Bouleau, Arthur; Ilijević, Konstantin; Roganović, Jovana; Rakić, Vesna

(2024)

TY  - JOUR
AU  - Đekić, Ilija
AU  - Lević, Steva
AU  - Šmigić, Nada
AU  - Bouleau, Arthur
AU  - Ilijević, Konstantin
AU  - Roganović, Jovana
AU  - Rakić, Vesna
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6459
AB  - Titanium dioxide (TiO2) is banned in some countries but its use is still permitted in others. The global food supply chain is therefore challenged with the need to use rapid and reliable testing methods to either detect the presence of TiO2 or to quantify its concentration. The goal of this study was to determine the feasibility of using color, texture profile analysis, Raman microscopy, and X-ray fluorescence (XRF) spectroscopy to detect and quantify TiO2 in fillings used in the pastry and confectionery industry. In this study, two types of fillings were investigated: vanilla based and chocolate based. All fillings were prepared in four different variations – without TiO2 and with three concentrations as follows: 0.25 g*kg-1, 0.5 g*kg-1, or 0.75 g*kg-1 TiO2 per sample. The methods were selected for their ability to analyze the samples in a short period of time. All of the methods showed moderate to high potential for detecting TiO2 in the samples. The results reveal how TiO2 affects the food matrix color and texture. Use of Raman microscopy confirms its detectability, although concentrations of TiO2 do not follow a pattern. X-ray fluorescence spectroscopy showed the greatest potential as it can not only detect TiO2 but can also quantify its concentration in the samples. The highest potential for quantifying the concentration of this food additive was achieved with XRF.
T2  - Journal of the Science of Food and Agriculture
T1  - Challenges and potential for detecting and quantifying titanium dioxide in food
VL  - n/a
DO  - 10.1002/jsfa.13356
ER  - 
@article{
author = "Đekić, Ilija and Lević, Steva and Šmigić, Nada and Bouleau, Arthur and Ilijević, Konstantin and Roganović, Jovana and Rakić, Vesna",
year = "2024",
abstract = "Titanium dioxide (TiO2) is banned in some countries but its use is still permitted in others. The global food supply chain is therefore challenged with the need to use rapid and reliable testing methods to either detect the presence of TiO2 or to quantify its concentration. The goal of this study was to determine the feasibility of using color, texture profile analysis, Raman microscopy, and X-ray fluorescence (XRF) spectroscopy to detect and quantify TiO2 in fillings used in the pastry and confectionery industry. In this study, two types of fillings were investigated: vanilla based and chocolate based. All fillings were prepared in four different variations – without TiO2 and with three concentrations as follows: 0.25 g*kg-1, 0.5 g*kg-1, or 0.75 g*kg-1 TiO2 per sample. The methods were selected for their ability to analyze the samples in a short period of time. All of the methods showed moderate to high potential for detecting TiO2 in the samples. The results reveal how TiO2 affects the food matrix color and texture. Use of Raman microscopy confirms its detectability, although concentrations of TiO2 do not follow a pattern. X-ray fluorescence spectroscopy showed the greatest potential as it can not only detect TiO2 but can also quantify its concentration in the samples. The highest potential for quantifying the concentration of this food additive was achieved with XRF.",
journal = "Journal of the Science of Food and Agriculture",
title = "Challenges and potential for detecting and quantifying titanium dioxide in food",
volume = "n/a",
doi = "10.1002/jsfa.13356"
}
Đekić, I., Lević, S., Šmigić, N., Bouleau, A., Ilijević, K., Roganović, J.,& Rakić, V.. (2024). Challenges and potential for detecting and quantifying titanium dioxide in food. in Journal of the Science of Food and Agriculture, n/a.
https://doi.org/10.1002/jsfa.13356
Đekić I, Lević S, Šmigić N, Bouleau A, Ilijević K, Roganović J, Rakić V. Challenges and potential for detecting and quantifying titanium dioxide in food. in Journal of the Science of Food and Agriculture. 2024;n/a.
doi:10.1002/jsfa.13356 .
Đekić, Ilija, Lević, Steva, Šmigić, Nada, Bouleau, Arthur, Ilijević, Konstantin, Roganović, Jovana, Rakić, Vesna, "Challenges and potential for detecting and quantifying titanium dioxide in food" in Journal of the Science of Food and Agriculture, n/a (2024),
https://doi.org/10.1002/jsfa.13356 . .

Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation

Vasović, Tamara; Gligorijević, Nikola; Lević, Steva M.; Miljević, Čedo; Nedić, Olgica; Nikolić, Milan

(FEBS Open Bio © 2021 FEBS, 2021)

TY  - CONF
AU  - Vasović, Tamara
AU  - Gligorijević, Nikola
AU  - Lević, Steva M.
AU  - Miljević, Čedo
AU  - Nedić, Olgica
AU  - Nikolić, Milan
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5134
AB  - Clozapine is an atypical antipsychotic used for the treatment of
schizophrenia. Prescribed daily doses of clozapine may reach
over 900 mg/day. Some studies reported a connection between
clozapine usage and the development of thrombosis. Our in vitro
study aimed to provide insight into molecular bases of this observation, investigating clozapine binding to isolated fibrinogen, the
main protein involved in hemostasis. Fibrinogen/clozapine interaction was confirmed by protein fluorescence quenching, with
affinity constant calculated to be 1.7 9 105 M1 and the number
of binding sites more than one. Direct interactions do not affect
the structure of fibrinogen, as determined by UV-VIS spectrometry and Fourier-transform infrared spectroscopy, nor fibrinogen
melting temperature, examined by fluorescence spectroscopy.
However, clozapine binding affected fibrin formation, by reducing coagulation speed and thickness of fibrin fibers. This behavior suggests that in the presence of clozapine, fibrinogen may
acquire thrombogenic characteristics. Although no difference in
fibrin gel porosity was detected, other factors present in the
blood may act synergistically with altered fibrin formation to
modify fibrin clot, thus increasing the risk for development of
thrombosis in individuals on clozapine treatment. By ORAC and
HORAC antioxidant assays, we found that clozapine efficiently
protects fibrinogen from free-radicals oxidation. Since the effect
of clozapine on fibrin formation is dose-dependent, it seems that
the dosage of the medication could be the main factor that determines if clozapine will have a more positive or negative effect on
fibrinogen and coagulation process in vivo.
PB  - FEBS Open Bio © 2021 FEBS
C3  - FEBS Open Bio, virtual 45th FEBS Congress from 3rd to 8th July 2021 (originally planned to be held in Ljubljana, Slovenia)
T1  - Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation
VL  - 11
SP  - 181
EP  - 181
DO  - doi:10.1002/2211-5463.13205
ER  - 
@conference{
author = "Vasović, Tamara and Gligorijević, Nikola and Lević, Steva M. and Miljević, Čedo and Nedić, Olgica and Nikolić, Milan",
year = "2021",
abstract = "Clozapine is an atypical antipsychotic used for the treatment of
schizophrenia. Prescribed daily doses of clozapine may reach
over 900 mg/day. Some studies reported a connection between
clozapine usage and the development of thrombosis. Our in vitro
study aimed to provide insight into molecular bases of this observation, investigating clozapine binding to isolated fibrinogen, the
main protein involved in hemostasis. Fibrinogen/clozapine interaction was confirmed by protein fluorescence quenching, with
affinity constant calculated to be 1.7 9 105 M1 and the number
of binding sites more than one. Direct interactions do not affect
the structure of fibrinogen, as determined by UV-VIS spectrometry and Fourier-transform infrared spectroscopy, nor fibrinogen
melting temperature, examined by fluorescence spectroscopy.
However, clozapine binding affected fibrin formation, by reducing coagulation speed and thickness of fibrin fibers. This behavior suggests that in the presence of clozapine, fibrinogen may
acquire thrombogenic characteristics. Although no difference in
fibrin gel porosity was detected, other factors present in the
blood may act synergistically with altered fibrin formation to
modify fibrin clot, thus increasing the risk for development of
thrombosis in individuals on clozapine treatment. By ORAC and
HORAC antioxidant assays, we found that clozapine efficiently
protects fibrinogen from free-radicals oxidation. Since the effect
of clozapine on fibrin formation is dose-dependent, it seems that
the dosage of the medication could be the main factor that determines if clozapine will have a more positive or negative effect on
fibrinogen and coagulation process in vivo.",
publisher = "FEBS Open Bio © 2021 FEBS",
journal = "FEBS Open Bio, virtual 45th FEBS Congress from 3rd to 8th July 2021 (originally planned to be held in Ljubljana, Slovenia)",
title = "Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation",
volume = "11",
pages = "181-181",
doi = "doi:10.1002/2211-5463.13205"
}
Vasović, T., Gligorijević, N., Lević, S. M., Miljević, Č., Nedić, O.,& Nikolić, M.. (2021). Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation. in FEBS Open Bio, virtual 45th FEBS Congress from 3rd to 8th July 2021 (originally planned to be held in Ljubljana, Slovenia)
FEBS Open Bio © 2021 FEBS., 11, 181-181.
https://doi.org/doi:10.1002/2211-5463.13205
Vasović T, Gligorijević N, Lević SM, Miljević Č, Nedić O, Nikolić M. Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation. in FEBS Open Bio, virtual 45th FEBS Congress from 3rd to 8th July 2021 (originally planned to be held in Ljubljana, Slovenia). 2021;11:181-181.
doi:doi:10.1002/2211-5463.13205 .
Vasović, Tamara, Gligorijević, Nikola, Lević, Steva M., Miljević, Čedo, Nedić, Olgica, Nikolić, Milan, "Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation" in FEBS Open Bio, virtual 45th FEBS Congress from 3rd to 8th July 2021 (originally planned to be held in Ljubljana, Slovenia), 11 (2021):181-181,
https://doi.org/doi:10.1002/2211-5463.13205 . .

Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties

Milinčić, Danijel D.; Kostić, Aleksandar Ž; Gašić, Uroš M.; Lević, Steva M.; Stanojević, Slađana P.; Barać, Miroljub B.; Tešić, Živoslav Lj.; Nedović, Viktor A.; Pešić, Mirjana B.

(MDPI, 2021)

TY  - JOUR
AU  - Milinčić, Danijel D.
AU  - Kostić, Aleksandar Ž
AU  - Gašić, Uroš M.
AU  - Lević, Steva M.
AU  - Stanojević, Slađana P.
AU  - Barać, Miroljub B.
AU  - Tešić, Živoslav Lj.
AU  - Nedović, Viktor A.
AU  - Pešić, Mirjana B.
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4610
AB  - The aim of this research was phenolics and protein characterization and antioxidant properties evaluation of skimmed thermally treated goat’s milk powder enriched with different concentration of grape pomace seed extract (SE). The dominant phenolics in SE were phenolic acids, flavan–3-ols and procyanidins. Different electrophoretic techniques together with UHPLC-MS/MS analysis revealed the presence of phenolics-protein interactions in the samples, mainly procyanidins with whey protein/caseins complexes. Addition of SE into thermally treated goat’s milk significantly improved antioxidant properties of goat’s milk such as TAC, FRP, DPPH• and ABTS•+ scavenging activity. Gallic acid, catechin, and procyanidins mostly contributed to these activities. The schematic representation of phenolics–casein micelles interactions in thermally treated goat’s milk enriched with SE was given. The addition of SE into thermally treated goat’s milk can be a promising strategy in food waste recovery and to enhance the beneficial health effects of goat’s milk-based functional foods.
PB  - MDPI
T2  - Biomolecules
T1  - Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties
VL  - 11
IS  - 7
SP  - 965
DO  - 10.3390/biom11070965
ER  - 
@article{
author = "Milinčić, Danijel D. and Kostić, Aleksandar Ž and Gašić, Uroš M. and Lević, Steva M. and Stanojević, Slađana P. and Barać, Miroljub B. and Tešić, Živoslav Lj. and Nedović, Viktor A. and Pešić, Mirjana B.",
year = "2021",
abstract = "The aim of this research was phenolics and protein characterization and antioxidant properties evaluation of skimmed thermally treated goat’s milk powder enriched with different concentration of grape pomace seed extract (SE). The dominant phenolics in SE were phenolic acids, flavan–3-ols and procyanidins. Different electrophoretic techniques together with UHPLC-MS/MS analysis revealed the presence of phenolics-protein interactions in the samples, mainly procyanidins with whey protein/caseins complexes. Addition of SE into thermally treated goat’s milk significantly improved antioxidant properties of goat’s milk such as TAC, FRP, DPPH• and ABTS•+ scavenging activity. Gallic acid, catechin, and procyanidins mostly contributed to these activities. The schematic representation of phenolics–casein micelles interactions in thermally treated goat’s milk enriched with SE was given. The addition of SE into thermally treated goat’s milk can be a promising strategy in food waste recovery and to enhance the beneficial health effects of goat’s milk-based functional foods.",
publisher = "MDPI",
journal = "Biomolecules",
title = "Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties",
volume = "11",
number = "7",
pages = "965",
doi = "10.3390/biom11070965"
}
Milinčić, D. D., Kostić, A. Ž., Gašić, U. M., Lević, S. M., Stanojević, S. P., Barać, M. B., Tešić, Ž. Lj., Nedović, V. A.,& Pešić, M. B.. (2021). Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties. in Biomolecules
MDPI., 11(7), 965.
https://doi.org/10.3390/biom11070965
Milinčić DD, Kostić AŽ, Gašić UM, Lević SM, Stanojević SP, Barać MB, Tešić ŽL, Nedović VA, Pešić MB. Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties. in Biomolecules. 2021;11(7):965.
doi:10.3390/biom11070965 .
Milinčić, Danijel D., Kostić, Aleksandar Ž, Gašić, Uroš M., Lević, Steva M., Stanojević, Slađana P., Barać, Miroljub B., Tešić, Živoslav Lj., Nedović, Viktor A., Pešić, Mirjana B., "Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties" in Biomolecules, 11, no. 7 (2021):965,
https://doi.org/10.3390/biom11070965 . .
11
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10
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Supplementary data for the article: Milinčić, D. D.; Kostić, A. Ž.; Gašić, U. M.; Lević, S.; Stanojević, S. P.; Barać, M. B.; Tešić, Ž. L.; Nedović, V.; Pešić, M. B. Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties. Biomolecules 2021, 11 (7), 965. https://doi.org/10.3390/biom11070965.

Milinčić, Danijel D.; Kostić, Aleksandar Ž; Gašić, Uroš M.; Lević, Steva M.; Stanojević, Slađana P.; Barać, Miroljub B.; Tešić, Živoslav Lj.; Nedović, Viktor A.; Pešić, Mirjana B.

(MDPI, 2021)

TY  - DATA
AU  - Milinčić, Danijel D.
AU  - Kostić, Aleksandar Ž
AU  - Gašić, Uroš M.
AU  - Lević, Steva M.
AU  - Stanojević, Slađana P.
AU  - Barać, Miroljub B.
AU  - Tešić, Živoslav Lj.
AU  - Nedović, Viktor A.
AU  - Pešić, Mirjana B.
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4611
PB  - MDPI
T2  - Biomolecules
T1  - Supplementary data for the article: Milinčić, D. D.; Kostić, A. Ž.; Gašić, U. M.; Lević, S.; Stanojević, S. P.; Barać, M. B.; Tešić, Ž. L.; Nedović, V.; Pešić, M. B. Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties. Biomolecules 2021, 11 (7), 965. https://doi.org/10.3390/biom11070965.
VL  - 11
IS  - 7
SP  - 965
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4611
ER  - 
@misc{
author = "Milinčić, Danijel D. and Kostić, Aleksandar Ž and Gašić, Uroš M. and Lević, Steva M. and Stanojević, Slađana P. and Barać, Miroljub B. and Tešić, Živoslav Lj. and Nedović, Viktor A. and Pešić, Mirjana B.",
year = "2021",
publisher = "MDPI",
journal = "Biomolecules",
title = "Supplementary data for the article: Milinčić, D. D.; Kostić, A. Ž.; Gašić, U. M.; Lević, S.; Stanojević, S. P.; Barać, M. B.; Tešić, Ž. L.; Nedović, V.; Pešić, M. B. Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties. Biomolecules 2021, 11 (7), 965. https://doi.org/10.3390/biom11070965.",
volume = "11",
number = "7",
pages = "965",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4611"
}
Milinčić, D. D., Kostić, A. Ž., Gašić, U. M., Lević, S. M., Stanojević, S. P., Barać, M. B., Tešić, Ž. Lj., Nedović, V. A.,& Pešić, M. B.. (2021). Supplementary data for the article: Milinčić, D. D.; Kostić, A. Ž.; Gašić, U. M.; Lević, S.; Stanojević, S. P.; Barać, M. B.; Tešić, Ž. L.; Nedović, V.; Pešić, M. B. Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties. Biomolecules 2021, 11 (7), 965. https://doi.org/10.3390/biom11070965.. in Biomolecules
MDPI., 11(7), 965.
https://hdl.handle.net/21.15107/rcub_cherry_4611
Milinčić DD, Kostić AŽ, Gašić UM, Lević SM, Stanojević SP, Barać MB, Tešić ŽL, Nedović VA, Pešić MB. Supplementary data for the article: Milinčić, D. D.; Kostić, A. Ž.; Gašić, U. M.; Lević, S.; Stanojević, S. P.; Barać, M. B.; Tešić, Ž. L.; Nedović, V.; Pešić, M. B. Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties. Biomolecules 2021, 11 (7), 965. https://doi.org/10.3390/biom11070965.. in Biomolecules. 2021;11(7):965.
https://hdl.handle.net/21.15107/rcub_cherry_4611 .
Milinčić, Danijel D., Kostić, Aleksandar Ž, Gašić, Uroš M., Lević, Steva M., Stanojević, Slađana P., Barać, Miroljub B., Tešić, Živoslav Lj., Nedović, Viktor A., Pešić, Mirjana B., "Supplementary data for the article: Milinčić, D. D.; Kostić, A. Ž.; Gašić, U. M.; Lević, S.; Stanojević, S. P.; Barać, M. B.; Tešić, Ž. L.; Nedović, V.; Pešić, M. B. Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties. Biomolecules 2021, 11 (7), 965. https://doi.org/10.3390/biom11070965." in Biomolecules, 11, no. 7 (2021):965,
https://hdl.handle.net/21.15107/rcub_cherry_4611 .
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Bio-membrane based on modified cellulose, lignin, and tannic acid for cation and oxyanion removal: Experimental and theoretical study

Perendija, Jovana; Veličković, Zlate S.; Cvijetić, Ilija; Lević, Steva M.; Marinković, Aleksandar; Milošević, Milena D.; Onjia, Antonije

(Elsevier, 2021)

TY  - JOUR
AU  - Perendija, Jovana
AU  - Veličković, Zlate S.
AU  - Cvijetić, Ilija
AU  - Lević, Steva M.
AU  - Marinković, Aleksandar
AU  - Milošević, Milena D.
AU  - Onjia, Antonije
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4770
AB  - Two optimized methods, based on epoxy-amino reactivity of the Cellulose fibres (Cell) modified with diethylenetriamine (Cell‒DETA), (3-Glycidyloxypropyl)trimethoxysilane (Cell-Glymo), Lignin modified with epichlorohydrine (EL) and Tannic acid (TA), as an additional crosslinker, were developed for the production of the bio-renewable Cell-EL and Cell-EL-TA membranes. The influences of pH, contact time, adsorbent dose, and temperature on adsorption performances were studied by batch adsorption tests. The calculated capacities: 53.9, 99.9, 97.8 and 63.5, 115.8, 127.5 mg g−1 for Ni2+, Pb2+, Cr(VI) using Cell-EL and Cell-EL-TA, respectively, were obtained from Langmuir model fitting at 25 °C. The thermodynamic parameters indicated spontaneous and low endothermic processes. The results of the kinetic study, i.e. pseudo-second-order (PSO) and Weber-Morris (W-M), suggest an intra-particle diffusion as a rate-limiting step. The semi-empirical quantum chemical calculations aided the analysis of the non-specific and specific adsorbent/adsorbate interactions and their contribution to the overall bonding mechanism. Membrane utility was confirmed by performing a bed column study. In general, three main environmental issues of the present study, biodegradability of the used membrane, desorption efficiency, and development of the technology for the effective effluent water treatment and safe disposal of by-products highly conform to the demand of integrated environmental management system applicability in practice.
PB  - Elsevier
T2  - Process Safety and Environmental Protection
T1  - Bio-membrane based on modified cellulose, lignin, and tannic acid for cation and oxyanion removal: Experimental and theoretical study
VL  - 147
SP  - 609
EP  - 625
DO  - 10.1016/j.psep.2020.12.027
ER  - 
@article{
author = "Perendija, Jovana and Veličković, Zlate S. and Cvijetić, Ilija and Lević, Steva M. and Marinković, Aleksandar and Milošević, Milena D. and Onjia, Antonije",
year = "2021",
abstract = "Two optimized methods, based on epoxy-amino reactivity of the Cellulose fibres (Cell) modified with diethylenetriamine (Cell‒DETA), (3-Glycidyloxypropyl)trimethoxysilane (Cell-Glymo), Lignin modified with epichlorohydrine (EL) and Tannic acid (TA), as an additional crosslinker, were developed for the production of the bio-renewable Cell-EL and Cell-EL-TA membranes. The influences of pH, contact time, adsorbent dose, and temperature on adsorption performances were studied by batch adsorption tests. The calculated capacities: 53.9, 99.9, 97.8 and 63.5, 115.8, 127.5 mg g−1 for Ni2+, Pb2+, Cr(VI) using Cell-EL and Cell-EL-TA, respectively, were obtained from Langmuir model fitting at 25 °C. The thermodynamic parameters indicated spontaneous and low endothermic processes. The results of the kinetic study, i.e. pseudo-second-order (PSO) and Weber-Morris (W-M), suggest an intra-particle diffusion as a rate-limiting step. The semi-empirical quantum chemical calculations aided the analysis of the non-specific and specific adsorbent/adsorbate interactions and their contribution to the overall bonding mechanism. Membrane utility was confirmed by performing a bed column study. In general, three main environmental issues of the present study, biodegradability of the used membrane, desorption efficiency, and development of the technology for the effective effluent water treatment and safe disposal of by-products highly conform to the demand of integrated environmental management system applicability in practice.",
publisher = "Elsevier",
journal = "Process Safety and Environmental Protection",
title = "Bio-membrane based on modified cellulose, lignin, and tannic acid for cation and oxyanion removal: Experimental and theoretical study",
volume = "147",
pages = "609-625",
doi = "10.1016/j.psep.2020.12.027"
}
Perendija, J., Veličković, Z. S., Cvijetić, I., Lević, S. M., Marinković, A., Milošević, M. D.,& Onjia, A.. (2021). Bio-membrane based on modified cellulose, lignin, and tannic acid for cation and oxyanion removal: Experimental and theoretical study. in Process Safety and Environmental Protection
Elsevier., 147, 609-625.
https://doi.org/10.1016/j.psep.2020.12.027
Perendija J, Veličković ZS, Cvijetić I, Lević SM, Marinković A, Milošević MD, Onjia A. Bio-membrane based on modified cellulose, lignin, and tannic acid for cation and oxyanion removal: Experimental and theoretical study. in Process Safety and Environmental Protection. 2021;147:609-625.
doi:10.1016/j.psep.2020.12.027 .
Perendija, Jovana, Veličković, Zlate S., Cvijetić, Ilija, Lević, Steva M., Marinković, Aleksandar, Milošević, Milena D., Onjia, Antonije, "Bio-membrane based on modified cellulose, lignin, and tannic acid for cation and oxyanion removal: Experimental and theoretical study" in Process Safety and Environmental Protection, 147 (2021):609-625,
https://doi.org/10.1016/j.psep.2020.12.027 . .
16
3
15
13

Supplementary data for the article: Perendija, J.; Veličković, Z. S.; Cvijetić, I.; Lević, S.; Marinković, A. D.; Milošević, M.; Onjia, A. Bio-Membrane Based on Modified Cellulose, Lignin, and Tannic Acid for Cation and Oxyanion Removal: Experimental and Theoretical Study. Process Safety and Environmental Protection 2021, 147, 609–625. https://doi.org/10.1016/j.psep.2020.12.027.

Perendija, Jovana; Veličković, Zlate S.; Cvijetić, Ilija; Lević, Steva M.; Marinković, Aleksandar; Milošević, Milena D.; Onjia, Antonije

(Institution of Chemical Engineers, 2021)

TY  - DATA
AU  - Perendija, Jovana
AU  - Veličković, Zlate S.
AU  - Cvijetić, Ilija
AU  - Lević, Steva M.
AU  - Marinković, Aleksandar
AU  - Milošević, Milena D.
AU  - Onjia, Antonije
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4771
PB  - Institution of Chemical Engineers
PB  - Elsevier
T2  - Process Safety and Environmental Protection
T1  - Supplementary data for the article: Perendija, J.; Veličković, Z. S.; Cvijetić, I.; Lević, S.; Marinković, A. D.; Milošević, M.; Onjia, A. Bio-Membrane Based on Modified Cellulose, Lignin, and Tannic Acid for Cation and Oxyanion Removal: Experimental and Theoretical Study. Process Safety and Environmental Protection 2021, 147, 609–625. https://doi.org/10.1016/j.psep.2020.12.027.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4771
ER  - 
@misc{
author = "Perendija, Jovana and Veličković, Zlate S. and Cvijetić, Ilija and Lević, Steva M. and Marinković, Aleksandar and Milošević, Milena D. and Onjia, Antonije",
year = "2021",
publisher = "Institution of Chemical Engineers, Elsevier",
journal = "Process Safety and Environmental Protection",
title = "Supplementary data for the article: Perendija, J.; Veličković, Z. S.; Cvijetić, I.; Lević, S.; Marinković, A. D.; Milošević, M.; Onjia, A. Bio-Membrane Based on Modified Cellulose, Lignin, and Tannic Acid for Cation and Oxyanion Removal: Experimental and Theoretical Study. Process Safety and Environmental Protection 2021, 147, 609–625. https://doi.org/10.1016/j.psep.2020.12.027.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4771"
}
Perendija, J., Veličković, Z. S., Cvijetić, I., Lević, S. M., Marinković, A., Milošević, M. D.,& Onjia, A.. (2021). Supplementary data for the article: Perendija, J.; Veličković, Z. S.; Cvijetić, I.; Lević, S.; Marinković, A. D.; Milošević, M.; Onjia, A. Bio-Membrane Based on Modified Cellulose, Lignin, and Tannic Acid for Cation and Oxyanion Removal: Experimental and Theoretical Study. Process Safety and Environmental Protection 2021, 147, 609–625. https://doi.org/10.1016/j.psep.2020.12.027.. in Process Safety and Environmental Protection
Institution of Chemical Engineers..
https://hdl.handle.net/21.15107/rcub_cherry_4771
Perendija J, Veličković ZS, Cvijetić I, Lević SM, Marinković A, Milošević MD, Onjia A. Supplementary data for the article: Perendija, J.; Veličković, Z. S.; Cvijetić, I.; Lević, S.; Marinković, A. D.; Milošević, M.; Onjia, A. Bio-Membrane Based on Modified Cellulose, Lignin, and Tannic Acid for Cation and Oxyanion Removal: Experimental and Theoretical Study. Process Safety and Environmental Protection 2021, 147, 609–625. https://doi.org/10.1016/j.psep.2020.12.027.. in Process Safety and Environmental Protection. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4771 .
Perendija, Jovana, Veličković, Zlate S., Cvijetić, Ilija, Lević, Steva M., Marinković, Aleksandar, Milošević, Milena D., Onjia, Antonije, "Supplementary data for the article: Perendija, J.; Veličković, Z. S.; Cvijetić, I.; Lević, S.; Marinković, A. D.; Milošević, M.; Onjia, A. Bio-Membrane Based on Modified Cellulose, Lignin, and Tannic Acid for Cation and Oxyanion Removal: Experimental and Theoretical Study. Process Safety and Environmental Protection 2021, 147, 609–625. https://doi.org/10.1016/j.psep.2020.12.027." in Process Safety and Environmental Protection (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4771 .

Polyphenol bioaccessibility and antioxidant properties of in vitro digested spray-dried thermally-treated skimmed goat milk enriched with pollen

Kostić, Aleksandar Ž.; Milinčić, Danijel D.; Stanisavljević, Nemanja S.; Gašić, Uroš M.; Lević, Steva M.; Kojić, Milan O.; Tešić, Živoslav Lj.; Nedović, Viktor A.; Barać, Miroljub B.; Pešić, Mirjana B.

(Elsevier, 2021)

TY  - JOUR
AU  - Kostić, Aleksandar Ž.
AU  - Milinčić, Danijel D.
AU  - Stanisavljević, Nemanja S.
AU  - Gašić, Uroš M.
AU  - Lević, Steva M.
AU  - Kojić, Milan O.
AU  - Tešić, Živoslav Lj.
AU  - Nedović, Viktor A.
AU  - Barać, Miroljub B.
AU  - Pešić, Mirjana B.
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S0308814621003162?via%3Dihub
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4407
AB  - The aim of research was to determine polyphenols bioaccessibility and antioxidant properties of thermally-treated skimmed goat milk enriched with sunflower bee-collected pollen through in vitro digestion. HPLC analysis confirmed that pollen-enriched milk contained flavonols as the main phenolic fraction (80.7–76.2%) followed by phenolic acids (14.2–17.4%). Among individual compounds quercetin-3-O-glucoside (155.1–197.2 μg/L) and p-coumaric acid (29.5–30.7 μg/L) were the main quantified flavonols and phenolic acids, respectively. After digestion of milk/pollen sample, total polyphenols recovery was 30.71% with higher phenolic acids recovery (40.1%) compared to flavonols (28.3%) indicating strong interactions between caprine milk casein micelles and pollen polyphenols. Applied antioxidant assays (phosphomolybdenum, ABTS•+scavenging activity and ferrous-ion-chelating capacity) have confirmed complexity of prepared product- it had high ability to quench ABTS•+ radicals and to form chelating complexes with Fe2+ ions. Digestion provoked 20% reduction in total antioxidant capacity compared to the initial sample. TTSG milk/pollen powder could be good functional ingredient. © 2021 Elsevier Ltd
PB  - Elsevier
T2  - Food Chemistry
T2  - Food Chemistry
T1  - Polyphenol bioaccessibility and antioxidant properties of in vitro digested spray-dried thermally-treated skimmed goat milk enriched with pollen
VL  - 351
SP  - 129310
DO  - 10.1016/j.foodchem.2021.129310
ER  - 
@article{
author = "Kostić, Aleksandar Ž. and Milinčić, Danijel D. and Stanisavljević, Nemanja S. and Gašić, Uroš M. and Lević, Steva M. and Kojić, Milan O. and Tešić, Živoslav Lj. and Nedović, Viktor A. and Barać, Miroljub B. and Pešić, Mirjana B.",
year = "2021",
abstract = "The aim of research was to determine polyphenols bioaccessibility and antioxidant properties of thermally-treated skimmed goat milk enriched with sunflower bee-collected pollen through in vitro digestion. HPLC analysis confirmed that pollen-enriched milk contained flavonols as the main phenolic fraction (80.7–76.2%) followed by phenolic acids (14.2–17.4%). Among individual compounds quercetin-3-O-glucoside (155.1–197.2 μg/L) and p-coumaric acid (29.5–30.7 μg/L) were the main quantified flavonols and phenolic acids, respectively. After digestion of milk/pollen sample, total polyphenols recovery was 30.71% with higher phenolic acids recovery (40.1%) compared to flavonols (28.3%) indicating strong interactions between caprine milk casein micelles and pollen polyphenols. Applied antioxidant assays (phosphomolybdenum, ABTS•+scavenging activity and ferrous-ion-chelating capacity) have confirmed complexity of prepared product- it had high ability to quench ABTS•+ radicals and to form chelating complexes with Fe2+ ions. Digestion provoked 20% reduction in total antioxidant capacity compared to the initial sample. TTSG milk/pollen powder could be good functional ingredient. © 2021 Elsevier Ltd",
publisher = "Elsevier",
journal = "Food Chemistry, Food Chemistry",
title = "Polyphenol bioaccessibility and antioxidant properties of in vitro digested spray-dried thermally-treated skimmed goat milk enriched with pollen",
volume = "351",
pages = "129310",
doi = "10.1016/j.foodchem.2021.129310"
}
Kostić, A. Ž., Milinčić, D. D., Stanisavljević, N. S., Gašić, U. M., Lević, S. M., Kojić, M. O., Tešić, Ž. Lj., Nedović, V. A., Barać, M. B.,& Pešić, M. B.. (2021). Polyphenol bioaccessibility and antioxidant properties of in vitro digested spray-dried thermally-treated skimmed goat milk enriched with pollen. in Food Chemistry
Elsevier., 351, 129310.
https://doi.org/10.1016/j.foodchem.2021.129310
Kostić AŽ, Milinčić DD, Stanisavljević NS, Gašić UM, Lević SM, Kojić MO, Tešić ŽL, Nedović VA, Barać MB, Pešić MB. Polyphenol bioaccessibility and antioxidant properties of in vitro digested spray-dried thermally-treated skimmed goat milk enriched with pollen. in Food Chemistry. 2021;351:129310.
doi:10.1016/j.foodchem.2021.129310 .
Kostić, Aleksandar Ž., Milinčić, Danijel D., Stanisavljević, Nemanja S., Gašić, Uroš M., Lević, Steva M., Kojić, Milan O., Tešić, Živoslav Lj., Nedović, Viktor A., Barać, Miroljub B., Pešić, Mirjana B., "Polyphenol bioaccessibility and antioxidant properties of in vitro digested spray-dried thermally-treated skimmed goat milk enriched with pollen" in Food Chemistry, 351 (2021):129310,
https://doi.org/10.1016/j.foodchem.2021.129310 . .
38
5
31
28

Supplementary data for the article: Kostić, A. Ž.; Milinčić, D. D.; Stanisavljević, N. S.; Gašić, U. M.; Lević, S.; Kojić, M. O.; Lj. Tešić, Ž.; Nedović, V.; Barać, M. B.; Pešić, M. B. Polyphenol Bioaccessibility and Antioxidant Properties of in Vitro Digested Spray-Dried Thermally-Treated Skimmed Goat Milk Enriched with Pollen. Food Chemistry 2021, 351. https://doi.org/10.1016/j.foodchem.2021.129310.

Kostić, Aleksandar Ž.; Milinčić, Danijel D.; Stanisavljević, Nemanja S.; Gašić, Uroš M.; Lević, Steva M.; Kojić, Milan O.; Tešić, Živoslav Lj.; Nedović, Viktor A.; Barać, Miroljub B.; Pešić, Mirjana B.

(Elsevier, 2021)

TY  - DATA
AU  - Kostić, Aleksandar Ž.
AU  - Milinčić, Danijel D.
AU  - Stanisavljević, Nemanja S.
AU  - Gašić, Uroš M.
AU  - Lević, Steva M.
AU  - Kojić, Milan O.
AU  - Tešić, Živoslav Lj.
AU  - Nedović, Viktor A.
AU  - Barać, Miroljub B.
AU  - Pešić, Mirjana B.
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S0308814621003162?via%3Dihub
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4408
PB  - Elsevier
T2  - Food Chemistry
T1  - Supplementary data for the article: Kostić, A. Ž.; Milinčić, D. D.; Stanisavljević, N. S.; Gašić, U. M.; Lević, S.; Kojić, M. O.; Lj. Tešić, Ž.; Nedović, V.; Barać, M. B.; Pešić, M. B. Polyphenol Bioaccessibility and Antioxidant Properties of in Vitro Digested Spray-Dried Thermally-Treated Skimmed Goat Milk Enriched with Pollen. Food Chemistry 2021, 351. https://doi.org/10.1016/j.foodchem.2021.129310.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4408
ER  - 
@misc{
author = "Kostić, Aleksandar Ž. and Milinčić, Danijel D. and Stanisavljević, Nemanja S. and Gašić, Uroš M. and Lević, Steva M. and Kojić, Milan O. and Tešić, Živoslav Lj. and Nedović, Viktor A. and Barać, Miroljub B. and Pešić, Mirjana B.",
year = "2021",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Supplementary data for the article: Kostić, A. Ž.; Milinčić, D. D.; Stanisavljević, N. S.; Gašić, U. M.; Lević, S.; Kojić, M. O.; Lj. Tešić, Ž.; Nedović, V.; Barać, M. B.; Pešić, M. B. Polyphenol Bioaccessibility and Antioxidant Properties of in Vitro Digested Spray-Dried Thermally-Treated Skimmed Goat Milk Enriched with Pollen. Food Chemistry 2021, 351. https://doi.org/10.1016/j.foodchem.2021.129310.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4408"
}
Kostić, A. Ž., Milinčić, D. D., Stanisavljević, N. S., Gašić, U. M., Lević, S. M., Kojić, M. O., Tešić, Ž. Lj., Nedović, V. A., Barać, M. B.,& Pešić, M. B.. (2021). Supplementary data for the article: Kostić, A. Ž.; Milinčić, D. D.; Stanisavljević, N. S.; Gašić, U. M.; Lević, S.; Kojić, M. O.; Lj. Tešić, Ž.; Nedović, V.; Barać, M. B.; Pešić, M. B. Polyphenol Bioaccessibility and Antioxidant Properties of in Vitro Digested Spray-Dried Thermally-Treated Skimmed Goat Milk Enriched with Pollen. Food Chemistry 2021, 351. https://doi.org/10.1016/j.foodchem.2021.129310.. in Food Chemistry
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4408
Kostić AŽ, Milinčić DD, Stanisavljević NS, Gašić UM, Lević SM, Kojić MO, Tešić ŽL, Nedović VA, Barać MB, Pešić MB. Supplementary data for the article: Kostić, A. Ž.; Milinčić, D. D.; Stanisavljević, N. S.; Gašić, U. M.; Lević, S.; Kojić, M. O.; Lj. Tešić, Ž.; Nedović, V.; Barać, M. B.; Pešić, M. B. Polyphenol Bioaccessibility and Antioxidant Properties of in Vitro Digested Spray-Dried Thermally-Treated Skimmed Goat Milk Enriched with Pollen. Food Chemistry 2021, 351. https://doi.org/10.1016/j.foodchem.2021.129310.. in Food Chemistry. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4408 .
Kostić, Aleksandar Ž., Milinčić, Danijel D., Stanisavljević, Nemanja S., Gašić, Uroš M., Lević, Steva M., Kojić, Milan O., Tešić, Živoslav Lj., Nedović, Viktor A., Barać, Miroljub B., Pešić, Mirjana B., "Supplementary data for the article: Kostić, A. Ž.; Milinčić, D. D.; Stanisavljević, N. S.; Gašić, U. M.; Lević, S.; Kojić, M. O.; Lj. Tešić, Ž.; Nedović, V.; Barać, M. B.; Pešić, M. B. Polyphenol Bioaccessibility and Antioxidant Properties of in Vitro Digested Spray-Dried Thermally-Treated Skimmed Goat Milk Enriched with Pollen. Food Chemistry 2021, 351. https://doi.org/10.1016/j.foodchem.2021.129310." in Food Chemistry (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4408 .

Ligand binding to fibrinogen influences its structure and function

Gligorijević, Nikola; Minić, Simeon L.; Radomirović, Mirjana Ž.; Lević, Steva M.; Nikolić, Milan; Ćirković-Veličković, Tanja; Nedić, Olgica

(University of Novi Sad - Faculty of Sciences, Department of Biology, 2021)

TY  - JOUR
AU  - Gligorijević, Nikola
AU  - Minić, Simeon L.
AU  - Radomirović, Mirjana Ž.
AU  - Lević, Steva M.
AU  - Nikolić, Milan
AU  - Ćirković-Veličković, Tanja
AU  - Nedić, Olgica
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4862
AB  - Fibrinogen is a plasma protein that is highly susceptible to oxidation. Because of this chemical modification, fibrinogen acquires thrombogenic characteristics under different pathophysiological conditions. Increased carbonyl content and reduced porosity impair the degradation of formed fibrin mediated by plasmin. Fibrinogen is capable of interacting with many proteins, ions, and small molecules. These interactions can modify the functions of this protein. The discovery of new binding partners that may protect fibrinogen from harmful oxidation and, thus, preserve its normal function is essential. Some of the newly detected interactions between fibrinogen and small, natural bioactive molecules, together with the influence of these interactions on the structure and function of fibrinogen, will be presented in this text.
PB  - University of Novi Sad - Faculty of Sciences, Department of Biology
T2  - Biologia Serbica
T1  - Ligand binding to fibrinogen influences its structure and function
VL  - 43
IS  - 1
DO  - 10.5281/zenodo.5512285
ER  - 
@article{
author = "Gligorijević, Nikola and Minić, Simeon L. and Radomirović, Mirjana Ž. and Lević, Steva M. and Nikolić, Milan and Ćirković-Veličković, Tanja and Nedić, Olgica",
year = "2021",
abstract = "Fibrinogen is a plasma protein that is highly susceptible to oxidation. Because of this chemical modification, fibrinogen acquires thrombogenic characteristics under different pathophysiological conditions. Increased carbonyl content and reduced porosity impair the degradation of formed fibrin mediated by plasmin. Fibrinogen is capable of interacting with many proteins, ions, and small molecules. These interactions can modify the functions of this protein. The discovery of new binding partners that may protect fibrinogen from harmful oxidation and, thus, preserve its normal function is essential. Some of the newly detected interactions between fibrinogen and small, natural bioactive molecules, together with the influence of these interactions on the structure and function of fibrinogen, will be presented in this text.",
publisher = "University of Novi Sad - Faculty of Sciences, Department of Biology",
journal = "Biologia Serbica",
title = "Ligand binding to fibrinogen influences its structure and function",
volume = "43",
number = "1",
doi = "10.5281/zenodo.5512285"
}
Gligorijević, N., Minić, S. L., Radomirović, M. Ž., Lević, S. M., Nikolić, M., Ćirković-Veličković, T.,& Nedić, O.. (2021). Ligand binding to fibrinogen influences its structure and function. in Biologia Serbica
University of Novi Sad - Faculty of Sciences, Department of Biology., 43(1).
https://doi.org/10.5281/zenodo.5512285
Gligorijević N, Minić SL, Radomirović MŽ, Lević SM, Nikolić M, Ćirković-Veličković T, Nedić O. Ligand binding to fibrinogen influences its structure and function. in Biologia Serbica. 2021;43(1).
doi:10.5281/zenodo.5512285 .
Gligorijević, Nikola, Minić, Simeon L., Radomirović, Mirjana Ž., Lević, Steva M., Nikolić, Milan, Ćirković-Veličković, Tanja, Nedić, Olgica, "Ligand binding to fibrinogen influences its structure and function" in Biologia Serbica, 43, no. 1 (2021),
https://doi.org/10.5281/zenodo.5512285 . .
1

Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation

Gligorijević, Nikola; Vasović, Tamara; Lević, Steva M.; Miljević, Čedo; Nedić, Olgica; Nikolić, Milan

(Elsevier, 2020)

TY  - JOUR
AU  - Gligorijević, Nikola
AU  - Vasović, Tamara
AU  - Lević, Steva M.
AU  - Miljević, Čedo
AU  - Nedić, Olgica
AU  - Nikolić, Milan
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3886
AB  - Clozapine is an atypical antipsychotic used for the treatment of schizophrenia. The prescribed target daily doses may reach 900 mg. Literature studies report a connection between clozapine usage and thrombosis development. Our in vitro study aimed to provide insight into molecular bases of this observation, investigating clozapine binding to fibrinogen, the main plasma protein involved in hemostasis. Fibrinogen/clozapine interaction was confirmed by protein fluorescence quenching, with an affinity constant of 1.7 × 105 M−1. Direct interactions did not affect the structure of fibrinogen, nor fibrinogen melting temperature. Clozapine binding affected fibrin formation by reducing coagulation speed and thickness of fibrin fibers suggesting that in the presence of clozapine, fibrinogen may acquire thrombogenic characteristics. Although no difference in fibrin gel porosity was detected, other factors present in the blood may act synergistically with altered fibrin formation to modify fibrin clot, thus increasing the risk for development of thrombosis in patients on clozapine treatment. ORAC and HORAC assays showed that clozapine reduced free radical-induced oxidation of fibrinogen. All observed effects of clozapine on fibrinogen are dose-dependent, with the effect on fibrin formation being more pronounced.
PB  - Elsevier
T2  - International Journal of Biological Macromolecules
T1  - Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation
VL  - 154
SP  - 142
EP  - 149
DO  - 10.1016/j.ijbiomac.2020.03.119
ER  - 
@article{
author = "Gligorijević, Nikola and Vasović, Tamara and Lević, Steva M. and Miljević, Čedo and Nedić, Olgica and Nikolić, Milan",
year = "2020",
abstract = "Clozapine is an atypical antipsychotic used for the treatment of schizophrenia. The prescribed target daily doses may reach 900 mg. Literature studies report a connection between clozapine usage and thrombosis development. Our in vitro study aimed to provide insight into molecular bases of this observation, investigating clozapine binding to fibrinogen, the main plasma protein involved in hemostasis. Fibrinogen/clozapine interaction was confirmed by protein fluorescence quenching, with an affinity constant of 1.7 × 105 M−1. Direct interactions did not affect the structure of fibrinogen, nor fibrinogen melting temperature. Clozapine binding affected fibrin formation by reducing coagulation speed and thickness of fibrin fibers suggesting that in the presence of clozapine, fibrinogen may acquire thrombogenic characteristics. Although no difference in fibrin gel porosity was detected, other factors present in the blood may act synergistically with altered fibrin formation to modify fibrin clot, thus increasing the risk for development of thrombosis in patients on clozapine treatment. ORAC and HORAC assays showed that clozapine reduced free radical-induced oxidation of fibrinogen. All observed effects of clozapine on fibrinogen are dose-dependent, with the effect on fibrin formation being more pronounced.",
publisher = "Elsevier",
journal = "International Journal of Biological Macromolecules",
title = "Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation",
volume = "154",
pages = "142-149",
doi = "10.1016/j.ijbiomac.2020.03.119"
}
Gligorijević, N., Vasović, T., Lević, S. M., Miljević, Č., Nedić, O.,& Nikolić, M.. (2020). Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation. in International Journal of Biological Macromolecules
Elsevier., 154, 142-149.
https://doi.org/10.1016/j.ijbiomac.2020.03.119
Gligorijević N, Vasović T, Lević SM, Miljević Č, Nedić O, Nikolić M. Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation. in International Journal of Biological Macromolecules. 2020;154:142-149.
doi:10.1016/j.ijbiomac.2020.03.119 .
Gligorijević, Nikola, Vasović, Tamara, Lević, Steva M., Miljević, Čedo, Nedić, Olgica, Nikolić, Milan, "Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation" in International Journal of Biological Macromolecules, 154 (2020):142-149,
https://doi.org/10.1016/j.ijbiomac.2020.03.119 . .
11
2
10
9

Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation

Gligorijević, Nikola; Vasović, Tamara; Lević, Steva M.; Miljević, Čedo; Nedić, Olgica; Nikolić, Milan

(Elsevier, 2020)

TY  - JOUR
AU  - Gligorijević, Nikola
AU  - Vasović, Tamara
AU  - Lević, Steva M.
AU  - Miljević, Čedo
AU  - Nedić, Olgica
AU  - Nikolić, Milan
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3896
AB  - Clozapine is an atypical antipsychotic used for the treatment of schizophrenia. The prescribed target daily doses may reach 900 mg. Literature studies report a connection between clozapine usage and thrombosis development. Our in vitro study aimed to provide insight into molecular bases of this observation, investigating clozapine binding to fibrinogen, the main plasma protein involved in hemostasis. Fibrinogen/clozapine interaction was confirmed by protein fluorescence quenching, with an affinity constant of 1.7 × 105 M−1. Direct interactions did not affect the structure of fibrinogen, nor fibrinogen melting temperature. Clozapine binding affected fibrin formation by reducing coagulation speed and thickness of fibrin fibers suggesting that in the presence of clozapine, fibrinogen may acquire thrombogenic characteristics. Although no difference in fibrin gel porosity was detected, other factors present in the blood may act synergistically with altered fibrin formation to modify fibrin clot, thus increasing the risk for development of thrombosis in patients on clozapine treatment. ORAC and HORAC assays showed that clozapine reduced free radical-induced oxidation of fibrinogen. All observed effects of clozapine on fibrinogen are dose-dependent, with the effect on fibrin formation being more pronounced.
PB  - Elsevier
T2  - International Journal of Biological Macromolecules
T1  - Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation
VL  - 154
SP  - 142
EP  - 149
DO  - 10.1016/j.ijbiomac.2020.03.119
ER  - 
@article{
author = "Gligorijević, Nikola and Vasović, Tamara and Lević, Steva M. and Miljević, Čedo and Nedić, Olgica and Nikolić, Milan",
year = "2020",
abstract = "Clozapine is an atypical antipsychotic used for the treatment of schizophrenia. The prescribed target daily doses may reach 900 mg. Literature studies report a connection between clozapine usage and thrombosis development. Our in vitro study aimed to provide insight into molecular bases of this observation, investigating clozapine binding to fibrinogen, the main plasma protein involved in hemostasis. Fibrinogen/clozapine interaction was confirmed by protein fluorescence quenching, with an affinity constant of 1.7 × 105 M−1. Direct interactions did not affect the structure of fibrinogen, nor fibrinogen melting temperature. Clozapine binding affected fibrin formation by reducing coagulation speed and thickness of fibrin fibers suggesting that in the presence of clozapine, fibrinogen may acquire thrombogenic characteristics. Although no difference in fibrin gel porosity was detected, other factors present in the blood may act synergistically with altered fibrin formation to modify fibrin clot, thus increasing the risk for development of thrombosis in patients on clozapine treatment. ORAC and HORAC assays showed that clozapine reduced free radical-induced oxidation of fibrinogen. All observed effects of clozapine on fibrinogen are dose-dependent, with the effect on fibrin formation being more pronounced.",
publisher = "Elsevier",
journal = "International Journal of Biological Macromolecules",
title = "Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation",
volume = "154",
pages = "142-149",
doi = "10.1016/j.ijbiomac.2020.03.119"
}
Gligorijević, N., Vasović, T., Lević, S. M., Miljević, Č., Nedić, O.,& Nikolić, M.. (2020). Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation. in International Journal of Biological Macromolecules
Elsevier., 154, 142-149.
https://doi.org/10.1016/j.ijbiomac.2020.03.119
Gligorijević N, Vasović T, Lević SM, Miljević Č, Nedić O, Nikolić M. Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation. in International Journal of Biological Macromolecules. 2020;154:142-149.
doi:10.1016/j.ijbiomac.2020.03.119 .
Gligorijević, Nikola, Vasović, Tamara, Lević, Steva M., Miljević, Čedo, Nedić, Olgica, Nikolić, Milan, "Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation" in International Journal of Biological Macromolecules, 154 (2020):142-149,
https://doi.org/10.1016/j.ijbiomac.2020.03.119 . .
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9

Structure and properties of nanocrystalline tetragonal BaTiO3 prepared by combustion solid state synthesis

Filipović, S.; Anđelković, Ljubica; Jeremić, Dejan; Vulić, P.; Nikolić, A. S.; Marković, S.; Paunović, V.; Lević, Steva M.; Pavlović, Vladimir B.

(Association for ETRAN Society, 2020)

TY  - JOUR
AU  - Filipović, S.
AU  - Anđelković, Ljubica
AU  - Jeremić, Dejan
AU  - Vulić, P.
AU  - Nikolić, A. S.
AU  - Marković, S.
AU  - Paunović, V.
AU  - Lević, Steva M.
AU  - Pavlović, Vladimir B.
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4301
AB  - Barium titanate (BaTiO3) attracts high scientific and technological attention due to good dielectric and electromechanical properties. Although BaTiO3 is one of the most frequently investigated ferroelectric materials, the need for finding new and/or improved synthesis methods of this material still exists. In this paper, a novel, mild synthesis route for producing tetragonal BaTiO3 from barium nitrate and Ti-oxalate precursor is presented. Morphology of the prepared and subsequently sintered BaTiO3 was determined by SEM. Particle size distribution of the as prepared powder was monitored by the laser diffraction. The phase composition, structure and lattice dynamics were investigated by XRD and Raman spectroscopy. Finally, dielectric parameters were determined in the temperature range from 30 to 180ºC, and within a variety of frequencies. Curie temperature was detected at 130ºC.
PB  - Association for ETRAN Society
T2  - Science of Sintering
T1  - Structure and properties of nanocrystalline tetragonal BaTiO3 prepared by combustion solid state synthesis
VL  - 52
IS  - 3
SP  - 257
EP  - 268
DO  - 10.2298/SOS2003257F
ER  - 
@article{
author = "Filipović, S. and Anđelković, Ljubica and Jeremić, Dejan and Vulić, P. and Nikolić, A. S. and Marković, S. and Paunović, V. and Lević, Steva M. and Pavlović, Vladimir B.",
year = "2020",
abstract = "Barium titanate (BaTiO3) attracts high scientific and technological attention due to good dielectric and electromechanical properties. Although BaTiO3 is one of the most frequently investigated ferroelectric materials, the need for finding new and/or improved synthesis methods of this material still exists. In this paper, a novel, mild synthesis route for producing tetragonal BaTiO3 from barium nitrate and Ti-oxalate precursor is presented. Morphology of the prepared and subsequently sintered BaTiO3 was determined by SEM. Particle size distribution of the as prepared powder was monitored by the laser diffraction. The phase composition, structure and lattice dynamics were investigated by XRD and Raman spectroscopy. Finally, dielectric parameters were determined in the temperature range from 30 to 180ºC, and within a variety of frequencies. Curie temperature was detected at 130ºC.",
publisher = "Association for ETRAN Society",
journal = "Science of Sintering",
title = "Structure and properties of nanocrystalline tetragonal BaTiO3 prepared by combustion solid state synthesis",
volume = "52",
number = "3",
pages = "257-268",
doi = "10.2298/SOS2003257F"
}
Filipović, S., Anđelković, L., Jeremić, D., Vulić, P., Nikolić, A. S., Marković, S., Paunović, V., Lević, S. M.,& Pavlović, V. B.. (2020). Structure and properties of nanocrystalline tetragonal BaTiO3 prepared by combustion solid state synthesis. in Science of Sintering
Association for ETRAN Society., 52(3), 257-268.
https://doi.org/10.2298/SOS2003257F
Filipović S, Anđelković L, Jeremić D, Vulić P, Nikolić AS, Marković S, Paunović V, Lević SM, Pavlović VB. Structure and properties of nanocrystalline tetragonal BaTiO3 prepared by combustion solid state synthesis. in Science of Sintering. 2020;52(3):257-268.
doi:10.2298/SOS2003257F .
Filipović, S., Anđelković, Ljubica, Jeremić, Dejan, Vulić, P., Nikolić, A. S., Marković, S., Paunović, V., Lević, Steva M., Pavlović, Vladimir B., "Structure and properties of nanocrystalline tetragonal BaTiO3 prepared by combustion solid state synthesis" in Science of Sintering, 52, no. 3 (2020):257-268,
https://doi.org/10.2298/SOS2003257F . .
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4

Application of polyphenol-loaded nanoparticles in food industry

Milinčić, Danijel D.; Popović, Dušanka A.; Lević, Steva M.; Kostić, Aleksandar Ž.; Tešić, Živoslav Lj.; Nedović, Viktor A.; Pešić, Mirjana B.

(MDPI, 2019)

TY  - JOUR
AU  - Milinčić, Danijel D.
AU  - Popović, Dušanka A.
AU  - Lević, Steva M.
AU  - Kostić, Aleksandar Ž.
AU  - Tešić, Živoslav Lj.
AU  - Nedović, Viktor A.
AU  - Pešić, Mirjana B.
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3780
AB  - Nanotechnology is an emerging field of science, and nanotechnological concepts have been intensively studied for potential applications in the food industry. Nanoparticles (with dimensions ranging from one to several hundred nanometers) have specific characteristics and better functionality, thanks to their size and other physicochemical properties. Polyphenols are recognized as active compounds that have several putative beneficial properties, including antioxidant, antimicrobial, and anticancer activity. However, the use of polyphenols as functional food ingredients faces numerous challenges, such as their poor stability, solubility, and bioavailability. These difficulties could be solved relatively easily by the application of encapsulation. The objective of this review is to present the most recent accomplishments in the usage of polyphenol-loaded nanoparticles in food science. Nanoparticles loaded with polyphenols and their applications as active ingredients for improving physicochemical and functional properties of food, or as components of active packaging materials, were critically reviewed. Potential adverse effects of polyphenol-loaded nanomaterials are also discussed.
PB  - MDPI
T2  - Nanomaterials
T1  - Application of polyphenol-loaded nanoparticles in food industry
VL  - 9
IS  - 11
SP  - 1629
DO  - 10.3390/nano9111629
ER  - 
@article{
author = "Milinčić, Danijel D. and Popović, Dušanka A. and Lević, Steva M. and Kostić, Aleksandar Ž. and Tešić, Živoslav Lj. and Nedović, Viktor A. and Pešić, Mirjana B.",
year = "2019",
abstract = "Nanotechnology is an emerging field of science, and nanotechnological concepts have been intensively studied for potential applications in the food industry. Nanoparticles (with dimensions ranging from one to several hundred nanometers) have specific characteristics and better functionality, thanks to their size and other physicochemical properties. Polyphenols are recognized as active compounds that have several putative beneficial properties, including antioxidant, antimicrobial, and anticancer activity. However, the use of polyphenols as functional food ingredients faces numerous challenges, such as their poor stability, solubility, and bioavailability. These difficulties could be solved relatively easily by the application of encapsulation. The objective of this review is to present the most recent accomplishments in the usage of polyphenol-loaded nanoparticles in food science. Nanoparticles loaded with polyphenols and their applications as active ingredients for improving physicochemical and functional properties of food, or as components of active packaging materials, were critically reviewed. Potential adverse effects of polyphenol-loaded nanomaterials are also discussed.",
publisher = "MDPI",
journal = "Nanomaterials",
title = "Application of polyphenol-loaded nanoparticles in food industry",
volume = "9",
number = "11",
pages = "1629",
doi = "10.3390/nano9111629"
}
Milinčić, D. D., Popović, D. A., Lević, S. M., Kostić, A. Ž., Tešić, Ž. Lj., Nedović, V. A.,& Pešić, M. B.. (2019). Application of polyphenol-loaded nanoparticles in food industry. in Nanomaterials
MDPI., 9(11), 1629.
https://doi.org/10.3390/nano9111629
Milinčić DD, Popović DA, Lević SM, Kostić AŽ, Tešić ŽL, Nedović VA, Pešić MB. Application of polyphenol-loaded nanoparticles in food industry. in Nanomaterials. 2019;9(11):1629.
doi:10.3390/nano9111629 .
Milinčić, Danijel D., Popović, Dušanka A., Lević, Steva M., Kostić, Aleksandar Ž., Tešić, Živoslav Lj., Nedović, Viktor A., Pešić, Mirjana B., "Application of polyphenol-loaded nanoparticles in food industry" in Nanomaterials, 9, no. 11 (2019):1629,
https://doi.org/10.3390/nano9111629 . .
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