TY  - DATA
AU  - Šenerović, Lidija
AU  - Živković, Marija
AU  - Veselinović, Aleksandar
AU  - Pavić, Aleksandar
AU  - Đuran, Miloš I.
AU  - Rajković, Snežana
AU  - Nikodinović-Runić, Jasmina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3440
PB  - Amer Chemical Soc, Washington
T2  - Journal of Medicinal Chemistry
T1  - Supplementary data for article: Senerovic, L.; Zivkovic, M. D.; Veselinovic, A.; Pavic, A.; Djuran, M. I.; Rajkovic, S.; Nikodinovic-Runic, J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. Journal of Medicinal Chemistry 2015, 58 (3), 1442–1451. https://doi.org/10.1021/jm5017686
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3440
ER  - 

@misc{
author = "Šenerović, Lidija and Živković, Marija and Veselinović, Aleksandar and Pavić, Aleksandar and Đuran, Miloš I. and Rajković, Snežana and Nikodinović-Runić, Jasmina",
year = "2015",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Medicinal Chemistry",
title = "Supplementary data for article: Senerovic, L.; Zivkovic, M. D.; Veselinovic, A.; Pavic, A.; Djuran, M. I.; Rajkovic, S.; Nikodinovic-Runic, J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. Journal of Medicinal Chemistry 2015, 58 (3), 1442–1451. https://doi.org/10.1021/jm5017686",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3440"
}

Šenerović, L., Živković, M., Veselinović, A., Pavić, A., Đuran, M. I., Rajković, S.,& Nikodinović-Runić, J.. (2015). Supplementary data for article: Senerovic, L.; Zivkovic, M. D.; Veselinovic, A.; Pavic, A.; Djuran, M. I.; Rajkovic, S.; Nikodinovic-Runic, J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. Journal of Medicinal Chemistry 2015, 58 (3), 1442–1451. https://doi.org/10.1021/jm5017686. in Journal of Medicinal Chemistry
Amer Chemical Soc, Washington..
https://hdl.handle.net/21.15107/rcub_cherry_3440

Šenerović L, Živković M, Veselinović A, Pavić A, Đuran MI, Rajković S, Nikodinović-Runić J. Supplementary data for article: Senerovic, L.; Zivkovic, M. D.; Veselinovic, A.; Pavic, A.; Djuran, M. I.; Rajkovic, S.; Nikodinovic-Runic, J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. Journal of Medicinal Chemistry 2015, 58 (3), 1442–1451. https://doi.org/10.1021/jm5017686. in Journal of Medicinal Chemistry. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3440 .

Šenerović, Lidija, Živković, Marija, Veselinović, Aleksandar, Pavić, Aleksandar, Đuran, Miloš I., Rajković, Snežana, Nikodinović-Runić, Jasmina, "Supplementary data for article: Senerovic, L.; Zivkovic, M. D.; Veselinovic, A.; Pavic, A.; Djuran, M. I.; Rajkovic, S.; Nikodinovic-Runic, J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. Journal of Medicinal Chemistry 2015, 58 (3), 1442–1451. https://doi.org/10.1021/jm5017686" in Journal of Medicinal Chemistry (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3440 .

TY  - JOUR
AU  - Šenerović, Lidija
AU  - Živković, Marija
AU  - Veselinović, Aleksandar
AU  - Pavić, Aleksandar
AU  - Đuran, Miloš I.
AU  - Rajković, Snežana
AU  - Nikodinović-Runić, Jasmina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1659
AB  - Polynuclear Pt(II) complexes are a novel class of promising anticancer agents with potential clinical significance. A series of pyrazine (pz) bridged dinuclear Pt(II) complexes with general formulas {[Pt(L)Cl](2)(mu-pz)}(2+) (L, ethylenediamine, en; (+/-)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(+/-)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2-dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd) and one pyridazine (pydz) bridged {[Pt(en)Cl](2)(mu-pydz)}(2+) complex were prepared. The anticancer potential of these complexes were determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two carcinoma cell lines (A375 and HCT116), interaction with double stranded DNA through in vitro assay, and molecular docking study. All complexes inhibited cell proliferation with inhibitory concentrations in the 0.5-120 mu M range. While {[Pt(1,3-pd)Cl](2)(mu-pz)}(2+) showed improved activity and {[Pt(en)Cl](2)(mu-pydz)}(2+) showed comparable activity to that of clinically relevant cisplatin, {[Pt(en)Cl](2)(mu-pydz)}(2+) was less toxic in an assay with zebrafish (Danio rerio) embryos, causing no adverse developmental effects. The in vitro cytotoxicity of all diazine-bridged dinuclear Pt(II) complexes is discussed in correlation to their structural characteristics.
PB  - Amer Chemical Soc, Washington
T2  - Journal of Medicinal Chemistry
T1  - Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes
VL  - 58
IS  - 3
SP  - 1442
EP  - 1451
DO  - 10.1021/jm5017686
ER  - 

@article{
author = "Šenerović, Lidija and Živković, Marija and Veselinović, Aleksandar and Pavić, Aleksandar and Đuran, Miloš I. and Rajković, Snežana and Nikodinović-Runić, Jasmina",
year = "2015",
abstract = "Polynuclear Pt(II) complexes are a novel class of promising anticancer agents with potential clinical significance. A series of pyrazine (pz) bridged dinuclear Pt(II) complexes with general formulas {[Pt(L)Cl](2)(mu-pz)}(2+) (L, ethylenediamine, en; (+/-)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(+/-)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2-dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd) and one pyridazine (pydz) bridged {[Pt(en)Cl](2)(mu-pydz)}(2+) complex were prepared. The anticancer potential of these complexes were determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two carcinoma cell lines (A375 and HCT116), interaction with double stranded DNA through in vitro assay, and molecular docking study. All complexes inhibited cell proliferation with inhibitory concentrations in the 0.5-120 mu M range. While {[Pt(1,3-pd)Cl](2)(mu-pz)}(2+) showed improved activity and {[Pt(en)Cl](2)(mu-pydz)}(2+) showed comparable activity to that of clinically relevant cisplatin, {[Pt(en)Cl](2)(mu-pydz)}(2+) was less toxic in an assay with zebrafish (Danio rerio) embryos, causing no adverse developmental effects. The in vitro cytotoxicity of all diazine-bridged dinuclear Pt(II) complexes is discussed in correlation to their structural characteristics.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Medicinal Chemistry",
title = "Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes",
volume = "58",
number = "3",
pages = "1442-1451",
doi = "10.1021/jm5017686"
}

Šenerović, L., Živković, M., Veselinović, A., Pavić, A., Đuran, M. I., Rajković, S.,& Nikodinović-Runić, J.. (2015). Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. in Journal of Medicinal Chemistry
Amer Chemical Soc, Washington., 58(3), 1442-1451.
https://doi.org/10.1021/jm5017686

Šenerović L, Živković M, Veselinović A, Pavić A, Đuran MI, Rajković S, Nikodinović-Runić J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. in Journal of Medicinal Chemistry. 2015;58(3):1442-1451.
doi:10.1021/jm5017686 .

Šenerović, Lidija, Živković, Marija, Veselinović, Aleksandar, Pavić, Aleksandar, Đuran, Miloš I., Rajković, Snežana, Nikodinović-Runić, Jasmina, "Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes" in Journal of Medicinal Chemistry, 58, no. 3 (2015):1442-1451,
https://doi.org/10.1021/jm5017686 . .