TY  - JOUR
AU  - Đurašević, Siniša
AU  - Jama, Adel
AU  - Jasnić, Nebojša
AU  - Vujovic, Predrag
AU  - Jovanović, Miloš
AU  - Mitić-Ćulafić, Dragana
AU  - Knežević-Vukčević, Jelena
AU  - Cakić Milosević, Maja
AU  - Ilijević, Konstantin
AU  - Popović-Đorđević, Jelena
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2401
AB  - One of the useful properties of probiotic bacteria is their capacity to bind different targets, thus eliminating them through feces. It is supposed that one of these targets could be cadmium, a widespread environmental toxicant that causes various disturbances in biological systems. This study examined the protective effects of probiotic supplementation against cadmium-induced toxicity in the rat. The experiment was conducted in the course of 5 weeks. Animals were divided into four groups: (1) controls, (2) probiotics treated, (3) cadmium treated, and (4) probiotics + cadmium treated. The cadmium concentration was measured in the blood, liver, kidney, and feces, as well as the blood alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as biomarkers of the liver function. Histomorphological changes in the liver and kidney were also determined. Our results revealed that probiotics combined with cadmium increase this metal concentration in feces. As a result, blood, liver, and kidney Cd levels, as well as blood ALT and AST activities were lessened compared to the rat group treated with cadmium only. Besides, probiotics consumed simultaneously with cadmium attenuated histomorphological changes in the liver and kidney caused by cadmium. The rise in lactobacilli number in feces of rats treated simultaneously with cadmium and probiotics results in strong correlation with the increase of Cd concentration in their feces and the decrease of Cd concentration in their blood. We speculate that probiotics actively contribute to cadmium excretion through feces, probably, by its binding to their bacterial cell wall.
PB  - Mary Ann Liebert, Inc, New Rochelle
T2  - Journal of Medicinal Food
T1  - The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats
VL  - 20
IS  - 2
SP  - 189
EP  - 196
DO  - 10.1089/jmf.2016.0090
ER  - 

@article{
author = "Đurašević, Siniša and Jama, Adel and Jasnić, Nebojša and Vujovic, Predrag and Jovanović, Miloš and Mitić-Ćulafić, Dragana and Knežević-Vukčević, Jelena and Cakić Milosević, Maja and Ilijević, Konstantin and Popović-Đorđević, Jelena",
year = "2017",
abstract = "One of the useful properties of probiotic bacteria is their capacity to bind different targets, thus eliminating them through feces. It is supposed that one of these targets could be cadmium, a widespread environmental toxicant that causes various disturbances in biological systems. This study examined the protective effects of probiotic supplementation against cadmium-induced toxicity in the rat. The experiment was conducted in the course of 5 weeks. Animals were divided into four groups: (1) controls, (2) probiotics treated, (3) cadmium treated, and (4) probiotics + cadmium treated. The cadmium concentration was measured in the blood, liver, kidney, and feces, as well as the blood alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as biomarkers of the liver function. Histomorphological changes in the liver and kidney were also determined. Our results revealed that probiotics combined with cadmium increase this metal concentration in feces. As a result, blood, liver, and kidney Cd levels, as well as blood ALT and AST activities were lessened compared to the rat group treated with cadmium only. Besides, probiotics consumed simultaneously with cadmium attenuated histomorphological changes in the liver and kidney caused by cadmium. The rise in lactobacilli number in feces of rats treated simultaneously with cadmium and probiotics results in strong correlation with the increase of Cd concentration in their feces and the decrease of Cd concentration in their blood. We speculate that probiotics actively contribute to cadmium excretion through feces, probably, by its binding to their bacterial cell wall.",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Journal of Medicinal Food",
title = "The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats",
volume = "20",
number = "2",
pages = "189-196",
doi = "10.1089/jmf.2016.0090"
}

Đurašević, S., Jama, A., Jasnić, N., Vujovic, P., Jovanović, M., Mitić-Ćulafić, D., Knežević-Vukčević, J., Cakić Milosević, M., Ilijević, K.,& Popović-Đorđević, J.. (2017). The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats. in Journal of Medicinal Food
Mary Ann Liebert, Inc, New Rochelle., 20(2), 189-196.
https://doi.org/10.1089/jmf.2016.0090

Đurašević S, Jama A, Jasnić N, Vujovic P, Jovanović M, Mitić-Ćulafić D, Knežević-Vukčević J, Cakić Milosević M, Ilijević K, Popović-Đorđević J. The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats. in Journal of Medicinal Food. 2017;20(2):189-196.
doi:10.1089/jmf.2016.0090 .

Đurašević, Siniša, Jama, Adel, Jasnić, Nebojša, Vujovic, Predrag, Jovanović, Miloš, Mitić-Ćulafić, Dragana, Knežević-Vukčević, Jelena, Cakić Milosević, Maja, Ilijević, Konstantin, Popović-Đorđević, Jelena, "The Protective Effects of Probiotic Bacteria on Cadmium Toxicity in Rats" in Journal of Medicinal Food, 20, no. 2 (2017):189-196,
https://doi.org/10.1089/jmf.2016.0090 . .