TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Damjanović, Ana
AU  - Stanojković, Tatjana
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Gođevac, Dejan
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3348
AB  - Metabolomics generate a profile of small molecules from plant extracts, which could be directly responsible for bioactivity effects. Using dry-column flash chromatography enabled a rapid and inexpensive method for the very efficient separation of plant extract with a high resolution. This separation method coupled to NMR and FTIR-based metabolomics is applied to identify bioactive natural products. OPLS multivariate analysis method, was used for correlation the chemical composition of the plant extracts, Amphoricarpos autariatus, with the results of cytotoxic activity against Human cervical adenocarcinoma cell line (HeLa) and epithelial lung cancer cell line (A549). In this way, the highest contribution to the cytotoxic activity was recorded for the guaianolide sesquiterpene lactones named amphoricarpolides. The compounds indicated as bioactive after metabolomics analysis were tested, and their cytotoxic activity were confirmed.
T2  - Talanta
T1  - Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus
VL  - 206
SP  - 1
EP  - 6
DO  - 10.1016/j.talanta.2019.120248
ER  - 

@article{
author = "Cvetković, Mirjana and Damjanović, Ana and Stanojković, Tatjana and Đorđević, Iris and Tešević, Vele and Milosavljević, Slobodan M. and Gođevac, Dejan",
year = "2020",
abstract = "Metabolomics generate a profile of small molecules from plant extracts, which could be directly responsible for bioactivity effects. Using dry-column flash chromatography enabled a rapid and inexpensive method for the very efficient separation of plant extract with a high resolution. This separation method coupled to NMR and FTIR-based metabolomics is applied to identify bioactive natural products. OPLS multivariate analysis method, was used for correlation the chemical composition of the plant extracts, Amphoricarpos autariatus, with the results of cytotoxic activity against Human cervical adenocarcinoma cell line (HeLa) and epithelial lung cancer cell line (A549). In this way, the highest contribution to the cytotoxic activity was recorded for the guaianolide sesquiterpene lactones named amphoricarpolides. The compounds indicated as bioactive after metabolomics analysis were tested, and their cytotoxic activity were confirmed.",
journal = "Talanta",
title = "Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus",
volume = "206",
pages = "1-6",
doi = "10.1016/j.talanta.2019.120248"
}

Cvetković, M., Damjanović, A., Stanojković, T., Đorđević, I., Tešević, V., Milosavljević, S. M.,& Gođevac, D.. (2020). Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus. in Talanta, 206, 1-6.
https://doi.org/10.1016/j.talanta.2019.120248

Cvetković M, Damjanović A, Stanojković T, Đorđević I, Tešević V, Milosavljević SM, Gođevac D. Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus. in Talanta. 2020;206:1-6.
doi:10.1016/j.talanta.2019.120248 .

Cvetković, Mirjana, Damjanović, Ana, Stanojković, Tatjana, Đorđević, Iris, Tešević, Vele, Milosavljević, Slobodan M., Gođevac, Dejan, "Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus" in Talanta, 206 (2020):1-6,
https://doi.org/10.1016/j.talanta.2019.120248 . .

TY  - DATA
AU  - Cvetković, Mirjana
AU  - Damjanović, Ana
AU  - Stanojković, Tatjana
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Gođevac, Dejan
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3349
T2  - Talanta
T1  - Supplementary material for the article: Cvetković, M.; Damjanović, A.; Stanojković, T. P.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. Integration of Dry-Column Flash Chromatography with NMR and FTIR Metabolomics to Reveal Cytotoxic Metabolites from Amphoricarpos Autariatus. Talanta 2020, 206. https://doi.org/10.1016/j.talanta.2019.120248
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3349
ER  - 

@misc{
author = "Cvetković, Mirjana and Damjanović, Ana and Stanojković, Tatjana and Đorđević, Iris and Tešević, Vele and Milosavljević, Slobodan M. and Gođevac, Dejan",
year = "2020",
journal = "Talanta",
title = "Supplementary material for the article: Cvetković, M.; Damjanović, A.; Stanojković, T. P.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. Integration of Dry-Column Flash Chromatography with NMR and FTIR Metabolomics to Reveal Cytotoxic Metabolites from Amphoricarpos Autariatus. Talanta 2020, 206. https://doi.org/10.1016/j.talanta.2019.120248",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3349"
}

Cvetković, M., Damjanović, A., Stanojković, T., Đorđević, I., Tešević, V., Milosavljević, S. M.,& Gođevac, D.. (2020). Supplementary material for the article: Cvetković, M.; Damjanović, A.; Stanojković, T. P.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. Integration of Dry-Column Flash Chromatography with NMR and FTIR Metabolomics to Reveal Cytotoxic Metabolites from Amphoricarpos Autariatus. Talanta 2020, 206. https://doi.org/10.1016/j.talanta.2019.120248. in Talanta.
https://hdl.handle.net/21.15107/rcub_cherry_3349

Cvetković M, Damjanović A, Stanojković T, Đorđević I, Tešević V, Milosavljević SM, Gođevac D. Supplementary material for the article: Cvetković, M.; Damjanović, A.; Stanojković, T. P.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. Integration of Dry-Column Flash Chromatography with NMR and FTIR Metabolomics to Reveal Cytotoxic Metabolites from Amphoricarpos Autariatus. Talanta 2020, 206. https://doi.org/10.1016/j.talanta.2019.120248. in Talanta. 2020;.
https://hdl.handle.net/21.15107/rcub_cherry_3349 .

Cvetković, Mirjana, Damjanović, Ana, Stanojković, Tatjana, Đorđević, Iris, Tešević, Vele, Milosavljević, Slobodan M., Gođevac, Dejan, "Supplementary material for the article: Cvetković, M.; Damjanović, A.; Stanojković, T. P.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. Integration of Dry-Column Flash Chromatography with NMR and FTIR Metabolomics to Reveal Cytotoxic Metabolites from Amphoricarpos Autariatus. Talanta 2020, 206. https://doi.org/10.1016/j.talanta.2019.120248" in Talanta (2020),
https://hdl.handle.net/21.15107/rcub_cherry_3349 .

TY  - JOUR
AU  - Sović, Irena
AU  - Cindrić, Maja
AU  - Perin, Nataša
AU  - Boček, Ida
AU  - Novaković, Irena T.
AU  - Damjanović, Ana
AU  - Stanojković, Tatjana
AU  - Zlatović, Mario
AU  - Hranjec, Marijana
AU  - Bertoša, Branimir
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3851
AB  - This paper discusses antioxidative and biological activities of 25 novel amidino substituted benzamides with a variety of heteroaromatic nuclei attached to the benzamide moiety and with a variable number of methoxy or hydroxy substituents. Targeted compounds, bearing either amidino or 2-imidazolinyl substituent, were obtained in the Pinner reaction from cyano precursors. 3D-QSAR models were generated to predict antioxidative activity of the 25 novel aromatic and heteroaromatic benzamide derivatives. The compounds were tested for antioxidative activity using in vitro spectrophotometric assays. Direct validation of 3D-QSAR approach for predicting activities of novel benzamide derivatives was carried out by comparing experimental and computationally predicted antioxidative activity. Experimentally determined activities for all novel compounds were found to be within a standard deviation of error of the models. Following this, structure–activity relationships among the synthesized compounds are discussed. Furthermore, antiproliferative activity in vitro against HeLa cells as well as antibacterial and antifungal activity was tested to confirm the other biological activities of the prepared compounds.
PB  - American Chemical Society
T2  - Chemical Research in Toxicology
T1  - Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity.
VL  - 32
IS  - 9
SP  - 1880
DO  - 10.1021/acs.chemrestox.9b00256
ER  - 

@article{
author = "Sović, Irena and Cindrić, Maja and Perin, Nataša and Boček, Ida and Novaković, Irena T. and Damjanović, Ana and Stanojković, Tatjana and Zlatović, Mario and Hranjec, Marijana and Bertoša, Branimir",
year = "2019",
abstract = "This paper discusses antioxidative and biological activities of 25 novel amidino substituted benzamides with a variety of heteroaromatic nuclei attached to the benzamide moiety and with a variable number of methoxy or hydroxy substituents. Targeted compounds, bearing either amidino or 2-imidazolinyl substituent, were obtained in the Pinner reaction from cyano precursors. 3D-QSAR models were generated to predict antioxidative activity of the 25 novel aromatic and heteroaromatic benzamide derivatives. The compounds were tested for antioxidative activity using in vitro spectrophotometric assays. Direct validation of 3D-QSAR approach for predicting activities of novel benzamide derivatives was carried out by comparing experimental and computationally predicted antioxidative activity. Experimentally determined activities for all novel compounds were found to be within a standard deviation of error of the models. Following this, structure–activity relationships among the synthesized compounds are discussed. Furthermore, antiproliferative activity in vitro against HeLa cells as well as antibacterial and antifungal activity was tested to confirm the other biological activities of the prepared compounds.",
publisher = "American Chemical Society",
journal = "Chemical Research in Toxicology",
title = "Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity.",
volume = "32",
number = "9",
pages = "1880",
doi = "10.1021/acs.chemrestox.9b00256"
}

Sović, I., Cindrić, M., Perin, N., Boček, I., Novaković, I. T., Damjanović, A., Stanojković, T., Zlatović, M., Hranjec, M.,& Bertoša, B.. (2019). Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity.. in Chemical Research in Toxicology
American Chemical Society., 32(9), 1880.
https://doi.org/10.1021/acs.chemrestox.9b00256

Sović I, Cindrić M, Perin N, Boček I, Novaković IT, Damjanović A, Stanojković T, Zlatović M, Hranjec M, Bertoša B. Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity.. in Chemical Research in Toxicology. 2019;32(9):1880.
doi:10.1021/acs.chemrestox.9b00256 .

Sović, Irena, Cindrić, Maja, Perin, Nataša, Boček, Ida, Novaković, Irena T., Damjanović, Ana, Stanojković, Tatjana, Zlatović, Mario, Hranjec, Marijana, Bertoša, Branimir, "Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity." in Chemical Research in Toxicology, 32, no. 9 (2019):1880,
https://doi.org/10.1021/acs.chemrestox.9b00256 . .

TY  - DATA
AU  - Sović, Irena
AU  - Cindrić, Maja
AU  - Perin, Nataša
AU  - Boček, Ida
AU  - Novaković, Irena T.
AU  - Damjanović, Ana
AU  - Stanojković, Tatjana
AU  - Zlatović, Mario
AU  - Hranjec, Marijana
AU  - Bertoša, Branimir
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3852
PB  - American Chemical Society
T2  - Chemical Research in Toxicology
T1  - Supplementary data for the article: Sović, I.; Cindrić, M.; Perin, N.; Boček, I.; Novaković, I.; Damjanović, A.; Stanojković, T.; Zlatović, M.; Hranjec, M.; Bertoša, B. Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity. Chemical Research in Toxicology 2019, 32 (9), 1880–1892. https://doi.org/10.1021/acs.chemrestox.9b00256
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3852
ER  - 

@misc{
author = "Sović, Irena and Cindrić, Maja and Perin, Nataša and Boček, Ida and Novaković, Irena T. and Damjanović, Ana and Stanojković, Tatjana and Zlatović, Mario and Hranjec, Marijana and Bertoša, Branimir",
year = "2019",
publisher = "American Chemical Society",
journal = "Chemical Research in Toxicology",
title = "Supplementary data for the article: Sović, I.; Cindrić, M.; Perin, N.; Boček, I.; Novaković, I.; Damjanović, A.; Stanojković, T.; Zlatović, M.; Hranjec, M.; Bertoša, B. Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity. Chemical Research in Toxicology 2019, 32 (9), 1880–1892. https://doi.org/10.1021/acs.chemrestox.9b00256",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3852"
}

Sović, I., Cindrić, M., Perin, N., Boček, I., Novaković, I. T., Damjanović, A., Stanojković, T., Zlatović, M., Hranjec, M.,& Bertoša, B.. (2019). Supplementary data for the article: Sović, I.; Cindrić, M.; Perin, N.; Boček, I.; Novaković, I.; Damjanović, A.; Stanojković, T.; Zlatović, M.; Hranjec, M.; Bertoša, B. Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity. Chemical Research in Toxicology 2019, 32 (9), 1880–1892. https://doi.org/10.1021/acs.chemrestox.9b00256. in Chemical Research in Toxicology
American Chemical Society..
https://hdl.handle.net/21.15107/rcub_cherry_3852

Sović I, Cindrić M, Perin N, Boček I, Novaković IT, Damjanović A, Stanojković T, Zlatović M, Hranjec M, Bertoša B. Supplementary data for the article: Sović, I.; Cindrić, M.; Perin, N.; Boček, I.; Novaković, I.; Damjanović, A.; Stanojković, T.; Zlatović, M.; Hranjec, M.; Bertoša, B. Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity. Chemical Research in Toxicology 2019, 32 (9), 1880–1892. https://doi.org/10.1021/acs.chemrestox.9b00256. in Chemical Research in Toxicology. 2019;.
https://hdl.handle.net/21.15107/rcub_cherry_3852 .

Sović, Irena, Cindrić, Maja, Perin, Nataša, Boček, Ida, Novaković, Irena T., Damjanović, Ana, Stanojković, Tatjana, Zlatović, Mario, Hranjec, Marijana, Bertoša, Branimir, "Supplementary data for the article: Sović, I.; Cindrić, M.; Perin, N.; Boček, I.; Novaković, I.; Damjanović, A.; Stanojković, T.; Zlatović, M.; Hranjec, M.; Bertoša, B. Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity. Chemical Research in Toxicology 2019, 32 (9), 1880–1892. https://doi.org/10.1021/acs.chemrestox.9b00256" in Chemical Research in Toxicology (2019),
https://hdl.handle.net/21.15107/rcub_cherry_3852 .

TY  - JOUR
AU  - Sović, Irena
AU  - Cindrić, Maja
AU  - Perin, Nataša
AU  - Boček, Ida
AU  - Novaković, Irena T.
AU  - Damjanović, Ana
AU  - Stanojković, Tatjana
AU  - Zlatović, Mario
AU  - Hranjec, Marijana
AU  - Bertoša, Branimir
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3914
AB  - This paper discusses antioxidative and biological activities of 25 novel amidino substituted benzamides with a variety of heteroaromatic nuclei attached to the benzamide moiety and with a variable number of methoxy or hydroxy substituents. Targeted compounds, bearing either amidino or 2-imidazolinyl substituent, were obtained in the Pinner reaction from cyano precursors. 3D-QSAR models were generated to predict antioxidative activity of the 25 novel aromatic and heteroaromatic benzamide derivatives. The compounds were tested for antioxidative activity using in vitro spectrophotometric assays. Direct validation of 3D-QSAR approach for predicting activities of novel benzamide derivatives was carried out by comparing experimental and computationally predicted antioxidative activity. Experimentally determined activities for all novel compounds were found to be within a standard deviation of error of the models. Following this, structure–activity relationships among the synthesized compounds are discussed. Furthermore, antiproliferative activity in vitro against HeLa cells as well as antibacterial and antifungal activity was tested to confirm the other biological activities of the prepared compounds.
PB  - American Chemical Society
T2  - Chemical Research in Toxicology
T1  - Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity.
VL  - 32
IS  - 9
SP  - 1880
DO  - 10.1021/acs.chemrestox.9b00256
ER  - 

@article{
author = "Sović, Irena and Cindrić, Maja and Perin, Nataša and Boček, Ida and Novaković, Irena T. and Damjanović, Ana and Stanojković, Tatjana and Zlatović, Mario and Hranjec, Marijana and Bertoša, Branimir",
year = "2019",
abstract = "This paper discusses antioxidative and biological activities of 25 novel amidino substituted benzamides with a variety of heteroaromatic nuclei attached to the benzamide moiety and with a variable number of methoxy or hydroxy substituents. Targeted compounds, bearing either amidino or 2-imidazolinyl substituent, were obtained in the Pinner reaction from cyano precursors. 3D-QSAR models were generated to predict antioxidative activity of the 25 novel aromatic and heteroaromatic benzamide derivatives. The compounds were tested for antioxidative activity using in vitro spectrophotometric assays. Direct validation of 3D-QSAR approach for predicting activities of novel benzamide derivatives was carried out by comparing experimental and computationally predicted antioxidative activity. Experimentally determined activities for all novel compounds were found to be within a standard deviation of error of the models. Following this, structure–activity relationships among the synthesized compounds are discussed. Furthermore, antiproliferative activity in vitro against HeLa cells as well as antibacterial and antifungal activity was tested to confirm the other biological activities of the prepared compounds.",
publisher = "American Chemical Society",
journal = "Chemical Research in Toxicology",
title = "Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity.",
volume = "32",
number = "9",
pages = "1880",
doi = "10.1021/acs.chemrestox.9b00256"
}

Sović, I., Cindrić, M., Perin, N., Boček, I., Novaković, I. T., Damjanović, A., Stanojković, T., Zlatović, M., Hranjec, M.,& Bertoša, B.. (2019). Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity.. in Chemical Research in Toxicology
American Chemical Society., 32(9), 1880.
https://doi.org/10.1021/acs.chemrestox.9b00256

Sović I, Cindrić M, Perin N, Boček I, Novaković IT, Damjanović A, Stanojković T, Zlatović M, Hranjec M, Bertoša B. Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity.. in Chemical Research in Toxicology. 2019;32(9):1880.
doi:10.1021/acs.chemrestox.9b00256 .

Sović, Irena, Cindrić, Maja, Perin, Nataša, Boček, Ida, Novaković, Irena T., Damjanović, Ana, Stanojković, Tatjana, Zlatović, Mario, Hranjec, Marijana, Bertoša, Branimir, "Biological Potential of Novel Methoxy and Hydroxy Substituted Heteroaromatic Amides Designed as Promising Antioxidative Agents: Synthesis, 3D-QSAR Analysis, and Biological Activity." in Chemical Research in Toxicology, 32, no. 9 (2019):1880,
https://doi.org/10.1021/acs.chemrestox.9b00256 . .

TY  - JOUR
AU  - Damjanović, Ana
AU  - Zdunić, Gordana
AU  - Šavikin, Katarina
AU  - Mandić, Boris
AU  - Jadranin, Milka
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2366
AB  - The cytotoxicity of Mahonia aquifolium ethanol and water extracts was examined using MTT test. The morphological changes were analyzed by fluorescence microscopy. Cell cycle distribution and possible activation of caspase-dependent pathway of cell death were assessed by flow cytometry. The effects of ethanol and water extracts on migration of endothelial EA. hy926 cells were analyzed by in vitro scratch assay and inhibition of angiogenesis was detected using tube formation assay. Both extracts demonstrated cytotoxic effects on cancer cell lines with very high selectivity. Morphological evaluation indicated apoptosis. These results were confirmed with cell cycle analysis, where there was accumulation of cancer cells in the subG1 phase. Ethanol and water extracts induced a caspase-dependent apoptosis in HeLa cells through activation of caspase-3 and caspase-8. Both extracts showed the ability to inbibit the migration of EA. hy926 cells and initial steps of angiogenesis. In addition, ethanol extract exerted significant anti-angiogenic effect.
PB  - Bangladesh Pharmacological Soc, Shahbah
T2  - Bangladesh Journal of Pharmacology
T1  - Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis
VL  - 11
IS  - 3
SP  - 741
EP  - 749
DO  - 10.3329/bjp.v11i3.27103
ER  - 

@article{
author = "Damjanović, Ana and Zdunić, Gordana and Šavikin, Katarina and Mandić, Boris and Jadranin, Milka and Matić, Ivana Z. and Stanojković, Tatjana",
year = "2016",
abstract = "The cytotoxicity of Mahonia aquifolium ethanol and water extracts was examined using MTT test. The morphological changes were analyzed by fluorescence microscopy. Cell cycle distribution and possible activation of caspase-dependent pathway of cell death were assessed by flow cytometry. The effects of ethanol and water extracts on migration of endothelial EA. hy926 cells were analyzed by in vitro scratch assay and inhibition of angiogenesis was detected using tube formation assay. Both extracts demonstrated cytotoxic effects on cancer cell lines with very high selectivity. Morphological evaluation indicated apoptosis. These results were confirmed with cell cycle analysis, where there was accumulation of cancer cells in the subG1 phase. Ethanol and water extracts induced a caspase-dependent apoptosis in HeLa cells through activation of caspase-3 and caspase-8. Both extracts showed the ability to inbibit the migration of EA. hy926 cells and initial steps of angiogenesis. In addition, ethanol extract exerted significant anti-angiogenic effect.",
publisher = "Bangladesh Pharmacological Soc, Shahbah",
journal = "Bangladesh Journal of Pharmacology",
title = "Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis",
volume = "11",
number = "3",
pages = "741-749",
doi = "10.3329/bjp.v11i3.27103"
}

Damjanović, A., Zdunić, G., Šavikin, K., Mandić, B., Jadranin, M., Matić, I. Z.,& Stanojković, T.. (2016). Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis. in Bangladesh Journal of Pharmacology
Bangladesh Pharmacological Soc, Shahbah., 11(3), 741-749.
https://doi.org/10.3329/bjp.v11i3.27103

Damjanović A, Zdunić G, Šavikin K, Mandić B, Jadranin M, Matić IZ, Stanojković T. Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis. in Bangladesh Journal of Pharmacology. 2016;11(3):741-749.
doi:10.3329/bjp.v11i3.27103 .

Damjanović, Ana, Zdunić, Gordana, Šavikin, Katarina, Mandić, Boris, Jadranin, Milka, Matić, Ivana Z., Stanojković, Tatjana, "Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis" in Bangladesh Journal of Pharmacology, 11, no. 3 (2016):741-749,
https://doi.org/10.3329/bjp.v11i3.27103 . .

TY  - JOUR
AU  - Pantelić, Nebojša Đ.
AU  - Zmejkovski, Bojana B.
AU  - Trifunović-Macedoljan, Jelena
AU  - Savić, Aleksandar
AU  - Stanković, Dalibor
AU  - Damjanović, Ana
AU  - Juranić, Zorica D.
AU  - Kaluđerović, Goran N.
AU  - Sabo, Tibor
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1422
AB  - Six novel gold(III) complexes containing O,O'-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate ([AuCl2{(S,S)-R(2)eddch}]PF6, R = Me, Et, n-Pr, n-Bu, i-Bu, i-Am; 1-6, respectively) were synthesized and characterized by elemental analysis, UV/Visible, IR and NMR spectroscopy, mass spectrometry and differential pulse voltammetry. Density functional theory (DFT) calculations confirmed that diastereoisomer with the N,N' atoms configured (S,S) was the most stable. In vitro antiproliferative activity was determined against human cervix adenocarcinoma HeLa and human myelogenous leukemia K562 tumor cell lines, as well as against rested and stimulated normal immunocompetent human peripheral blood mononuclear cells (PBMC) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Complex 6 expressed the highest activity against K562 cells (IC50 = 3.8 +/- 0.5 mu M). Apoptosis, seen as condensation of HeLa cell nuclei was the mode of cell death induced by complexes 2-6. Complexes 3-6 induced death of K562 cells inhibiting cell entry in mitosis.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetate
VL  - 128
SP  - 146
EP  - 153
DO  - 10.1016/j.jinorgbio.2013.08.002
ER  - 

@article{
author = "Pantelić, Nebojša Đ. and Zmejkovski, Bojana B. and Trifunović-Macedoljan, Jelena and Savić, Aleksandar and Stanković, Dalibor and Damjanović, Ana and Juranić, Zorica D. and Kaluđerović, Goran N. and Sabo, Tibor",
year = "2013",
abstract = "Six novel gold(III) complexes containing O,O'-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate ([AuCl2{(S,S)-R(2)eddch}]PF6, R = Me, Et, n-Pr, n-Bu, i-Bu, i-Am; 1-6, respectively) were synthesized and characterized by elemental analysis, UV/Visible, IR and NMR spectroscopy, mass spectrometry and differential pulse voltammetry. Density functional theory (DFT) calculations confirmed that diastereoisomer with the N,N' atoms configured (S,S) was the most stable. In vitro antiproliferative activity was determined against human cervix adenocarcinoma HeLa and human myelogenous leukemia K562 tumor cell lines, as well as against rested and stimulated normal immunocompetent human peripheral blood mononuclear cells (PBMC) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Complex 6 expressed the highest activity against K562 cells (IC50 = 3.8 +/- 0.5 mu M). Apoptosis, seen as condensation of HeLa cell nuclei was the mode of cell death induced by complexes 2-6. Complexes 3-6 induced death of K562 cells inhibiting cell entry in mitosis.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetate",
volume = "128",
pages = "146-153",
doi = "10.1016/j.jinorgbio.2013.08.002"
}

Pantelić, N. Đ., Zmejkovski, B. B., Trifunović-Macedoljan, J., Savić, A., Stanković, D., Damjanović, A., Juranić, Z. D., Kaluđerović, G. N.,& Sabo, T.. (2013). Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetate. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 128, 146-153.
https://doi.org/10.1016/j.jinorgbio.2013.08.002

Pantelić NĐ, Zmejkovski BB, Trifunović-Macedoljan J, Savić A, Stanković D, Damjanović A, Juranić ZD, Kaluđerović GN, Sabo T. Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetate. in Journal of Inorganic Biochemistry. 2013;128:146-153.
doi:10.1016/j.jinorgbio.2013.08.002 .

Pantelić, Nebojša Đ., Zmejkovski, Bojana B., Trifunović-Macedoljan, Jelena, Savić, Aleksandar, Stanković, Dalibor, Damjanović, Ana, Juranić, Zorica D., Kaluđerović, Goran N., Sabo, Tibor, "Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetate" in Journal of Inorganic Biochemistry, 128 (2013):146-153,
https://doi.org/10.1016/j.jinorgbio.2013.08.002 . .

TY  - DATA
AU  - Pantelić, Nebojša Đ.
AU  - Zmejkovski, Bojana B.
AU  - Trifunović-Macedoljan, Jelena
AU  - Savić, Aleksandar
AU  - Stanković, Dalibor
AU  - Damjanović, Ana
AU  - Juranić, Zorica D.
AU  - Kaluđerović, Goran N.
AU  - Sabo, Tibor
PY  - 2013
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3497
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Supplementary data for article: Pantelić, N. Đ.; Zmejkovski, B. B.; Trifunović-Macedoljan, J.; Savić, A.; Stanković, D.; Damjanović, A.; Juranic, Z.; Kaluđerović, G. N.; Sabo, T. Gold(III) Complexes with Esters of Cyclohexyl-Functionalized Ethylenediamine-N,N ’-Diacetate. Journal of Inorganic Biochemistry 2013, 128, 146–153. https://doi.org/10.1016/j.jinorgbio.2013.08.002
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3497
ER  - 

@misc{
author = "Pantelić, Nebojša Đ. and Zmejkovski, Bojana B. and Trifunović-Macedoljan, Jelena and Savić, Aleksandar and Stanković, Dalibor and Damjanović, Ana and Juranić, Zorica D. and Kaluđerović, Goran N. and Sabo, Tibor",
year = "2013",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Supplementary data for article: Pantelić, N. Đ.; Zmejkovski, B. B.; Trifunović-Macedoljan, J.; Savić, A.; Stanković, D.; Damjanović, A.; Juranic, Z.; Kaluđerović, G. N.; Sabo, T. Gold(III) Complexes with Esters of Cyclohexyl-Functionalized Ethylenediamine-N,N ’-Diacetate. Journal of Inorganic Biochemistry 2013, 128, 146–153. https://doi.org/10.1016/j.jinorgbio.2013.08.002",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3497"
}

Pantelić, N. Đ., Zmejkovski, B. B., Trifunović-Macedoljan, J., Savić, A., Stanković, D., Damjanović, A., Juranić, Z. D., Kaluđerović, G. N.,& Sabo, T.. (2013). Supplementary data for article: Pantelić, N. Đ.; Zmejkovski, B. B.; Trifunović-Macedoljan, J.; Savić, A.; Stanković, D.; Damjanović, A.; Juranic, Z.; Kaluđerović, G. N.; Sabo, T. Gold(III) Complexes with Esters of Cyclohexyl-Functionalized Ethylenediamine-N,N ’-Diacetate. Journal of Inorganic Biochemistry 2013, 128, 146–153. https://doi.org/10.1016/j.jinorgbio.2013.08.002. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York..
https://hdl.handle.net/21.15107/rcub_cherry_3497

Pantelić NĐ, Zmejkovski BB, Trifunović-Macedoljan J, Savić A, Stanković D, Damjanović A, Juranić ZD, Kaluđerović GN, Sabo T. Supplementary data for article: Pantelić, N. Đ.; Zmejkovski, B. B.; Trifunović-Macedoljan, J.; Savić, A.; Stanković, D.; Damjanović, A.; Juranic, Z.; Kaluđerović, G. N.; Sabo, T. Gold(III) Complexes with Esters of Cyclohexyl-Functionalized Ethylenediamine-N,N ’-Diacetate. Journal of Inorganic Biochemistry 2013, 128, 146–153. https://doi.org/10.1016/j.jinorgbio.2013.08.002. in Journal of Inorganic Biochemistry. 2013;.
https://hdl.handle.net/21.15107/rcub_cherry_3497 .

Pantelić, Nebojša Đ., Zmejkovski, Bojana B., Trifunović-Macedoljan, Jelena, Savić, Aleksandar, Stanković, Dalibor, Damjanović, Ana, Juranić, Zorica D., Kaluđerović, Goran N., Sabo, Tibor, "Supplementary data for article: Pantelić, N. Đ.; Zmejkovski, B. B.; Trifunović-Macedoljan, J.; Savić, A.; Stanković, D.; Damjanović, A.; Juranic, Z.; Kaluđerović, G. N.; Sabo, T. Gold(III) Complexes with Esters of Cyclohexyl-Functionalized Ethylenediamine-N,N ’-Diacetate. Journal of Inorganic Biochemistry 2013, 128, 146–153. https://doi.org/10.1016/j.jinorgbio.2013.08.002" in Journal of Inorganic Biochemistry (2013),
https://hdl.handle.net/21.15107/rcub_cherry_3497 .

TY  - CONF
AU  - Trifunović, Jelena
AU  - Jadranin, Milka
AU  - Damjanović, Ana
AU  - Rašković, Sanvila S.
AU  - Djurovic, M. N.
AU  - Draskovic, D.
AU  - Pudar, G.
AU  - Tešević, Vele
AU  - Juranić, Ivan O.
AU  - Juranić, Z.
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1535
PB  - Wiley-Blackwell, Hoboken
C3  - Immunology
T1  - LC/DAD analysis of serum biogenic amines in patients with diabetes mellitus, chronic urticaria and Hashimoto's thyroiditis
VL  - 137
SP  - 673
EP  - 673
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1535
ER  - 

@conference{
author = "Trifunović, Jelena and Jadranin, Milka and Damjanović, Ana and Rašković, Sanvila S. and Djurovic, M. N. and Draskovic, D. and Pudar, G. and Tešević, Vele and Juranić, Ivan O. and Juranić, Z.",
year = "2012",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Immunology",
title = "LC/DAD analysis of serum biogenic amines in patients with diabetes mellitus, chronic urticaria and Hashimoto's thyroiditis",
volume = "137",
pages = "673-673",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1535"
}

Trifunović, J., Jadranin, M., Damjanović, A., Rašković, S. S., Djurovic, M. N., Draskovic, D., Pudar, G., Tešević, V., Juranić, I. O.,& Juranić, Z.. (2012). LC/DAD analysis of serum biogenic amines in patients with diabetes mellitus, chronic urticaria and Hashimoto's thyroiditis. in Immunology
Wiley-Blackwell, Hoboken., 137, 673-673.
https://hdl.handle.net/21.15107/rcub_cherry_1535

Trifunović J, Jadranin M, Damjanović A, Rašković SS, Djurovic MN, Draskovic D, Pudar G, Tešević V, Juranić IO, Juranić Z. LC/DAD analysis of serum biogenic amines in patients with diabetes mellitus, chronic urticaria and Hashimoto's thyroiditis. in Immunology. 2012;137:673-673.
https://hdl.handle.net/21.15107/rcub_cherry_1535 .

Trifunović, Jelena, Jadranin, Milka, Damjanović, Ana, Rašković, Sanvila S., Djurovic, M. N., Draskovic, D., Pudar, G., Tešević, Vele, Juranić, Ivan O., Juranić, Z., "LC/DAD analysis of serum biogenic amines in patients with diabetes mellitus, chronic urticaria and Hashimoto's thyroiditis" in Immunology, 137 (2012):673-673,
https://hdl.handle.net/21.15107/rcub_cherry_1535 .

TY  - CONF
AU  - Trifunović, Jelena
AU  - Jadranin, Milka
AU  - Damjanović, Ana
AU  - Ristic, D.
AU  - Milanovic, N.
AU  - Tešević, Vele
AU  - Juranić, Ivan O.
AU  - Ristić, S.
AU  - Juranić, Z.
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1571
PB  - Elsevier Sci Ltd, Oxford
C3  - European Journal of Cancer / EJC
T1  - Serum Polyamines in Patients With Non-Hodgkin's Lymphoma
VL  - 48
DO  - 10.1016/S0959-8049(12)71111-5
ER  - 

@conference{
author = "Trifunović, Jelena and Jadranin, Milka and Damjanović, Ana and Ristic, D. and Milanovic, N. and Tešević, Vele and Juranić, Ivan O. and Ristić, S. and Juranić, Z.",
year = "2012",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "European Journal of Cancer / EJC",
title = "Serum Polyamines in Patients With Non-Hodgkin's Lymphoma",
volume = "48",
doi = "10.1016/S0959-8049(12)71111-5"
}

Trifunović, J., Jadranin, M., Damjanović, A., Ristic, D., Milanovic, N., Tešević, V., Juranić, I. O., Ristić, S.,& Juranić, Z.. (2012). Serum Polyamines in Patients With Non-Hodgkin's Lymphoma. in European Journal of Cancer / EJC
Elsevier Sci Ltd, Oxford., 48.
https://doi.org/10.1016/S0959-8049(12)71111-5

Trifunović J, Jadranin M, Damjanović A, Ristic D, Milanovic N, Tešević V, Juranić IO, Ristić S, Juranić Z. Serum Polyamines in Patients With Non-Hodgkin's Lymphoma. in European Journal of Cancer / EJC. 2012;48.
doi:10.1016/S0959-8049(12)71111-5 .

Trifunović, Jelena, Jadranin, Milka, Damjanović, Ana, Ristic, D., Milanovic, N., Tešević, Vele, Juranić, Ivan O., Ristić, S., Juranić, Z., "Serum Polyamines in Patients With Non-Hodgkin's Lymphoma" in European Journal of Cancer / EJC, 48 (2012),
https://doi.org/10.1016/S0959-8049(12)71111-5 . .