TY  - JOUR
AU  - Radulovic, Vesna M.
AU  - Roglić, Goran
AU  - Manojlović, Dragan D.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2521
AB  - Classical methods of wastewater treatment are often not suitable for the treatment of pharmaceutical waste. The previous studies have shown that the use of the advanced oxidation procedures (AOP) can lead to a more efficient degradation of various biologically active compounds, which are active pharmaceutical ingredients of applied drugs. The aim of this paper is the application of the plasma technology on the degradation of a two active pharmaceutical ingredients (APIs, diazepam and alprazolam) and the finished products (Bensedin((R)) and Ksalol((R))) using the dielectric barrier discharge (DBD) reactor for AOP. We studied the degradation rate of these pharmaceuticals, depending on the number of passes through the reactor. This degradation method was efficient 61 % for diazepam and 95 % alprazolam. We also examined the influence of the pH adjustment between the passes of APIs through the DBD reactor. The degradation rate of APIs and the finished products was monitored by the high performance liquid chromatography (HPLC) technique, using a photodiode array detector. The concentration of the dissolved ozone was determined using the iodometric procedure.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Degradation of benzodiazepines using water falling film dielectric barrier discharge reactor
VL  - 82
IS  - 7-8
SP  - 933
EP  - 942
DO  - 10.2298/JSC170118050R
ER  - 

@article{
author = "Radulovic, Vesna M. and Roglić, Goran and Manojlović, Dragan D.",
year = "2017",
abstract = "Classical methods of wastewater treatment are often not suitable for the treatment of pharmaceutical waste. The previous studies have shown that the use of the advanced oxidation procedures (AOP) can lead to a more efficient degradation of various biologically active compounds, which are active pharmaceutical ingredients of applied drugs. The aim of this paper is the application of the plasma technology on the degradation of a two active pharmaceutical ingredients (APIs, diazepam and alprazolam) and the finished products (Bensedin((R)) and Ksalol((R))) using the dielectric barrier discharge (DBD) reactor for AOP. We studied the degradation rate of these pharmaceuticals, depending on the number of passes through the reactor. This degradation method was efficient 61 % for diazepam and 95 % alprazolam. We also examined the influence of the pH adjustment between the passes of APIs through the DBD reactor. The degradation rate of APIs and the finished products was monitored by the high performance liquid chromatography (HPLC) technique, using a photodiode array detector. The concentration of the dissolved ozone was determined using the iodometric procedure.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Degradation of benzodiazepines using water falling film dielectric barrier discharge reactor",
volume = "82",
number = "7-8",
pages = "933-942",
doi = "10.2298/JSC170118050R"
}

Radulovic, V. M., Roglić, G.,& Manojlović, D. D.. (2017). Degradation of benzodiazepines using water falling film dielectric barrier discharge reactor. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 82(7-8), 933-942.
https://doi.org/10.2298/JSC170118050R

Radulovic VM, Roglić G, Manojlović DD. Degradation of benzodiazepines using water falling film dielectric barrier discharge reactor. in Journal of the Serbian Chemical Society. 2017;82(7-8):933-942.
doi:10.2298/JSC170118050R .

Radulovic, Vesna M., Roglić, Goran, Manojlović, Dragan D., "Degradation of benzodiazepines using water falling film dielectric barrier discharge reactor" in Journal of the Serbian Chemical Society, 82, no. 7-8 (2017):933-942,
https://doi.org/10.2298/JSC170118050R . .