TY  - JOUR
AU  - Pejčić, Tomislav
AU  - Zeković, Milica
AU  - Bumbaširević, Uroš
AU  - Kalaba, Milica
AU  - Vovk, Irena
AU  - Bensa, Maja
AU  - Popović, Lazar
AU  - Tešić, Živoslav Lj.
PY  - 2023
UR  - https://www.mdpi.com/2076-3921/12/2/368
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6181
AB  - This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms of action, and available data supporting the potential role of isoflavones in the prevention of breast cancer and prostate cancer are discussed. Studies evaluating the effects of isoflavones in tissue cultures of normal and malignant breast and prostate cells, as well as the current body of research regarding the effects of isoflavones attained through multiple modifications of cellular molecular signaling pathways and control of oxidative stress, are summarized. Furthermore, this review compiles literature sources reporting on the following: (1) levels of estrogen in breast and prostate tissue; (2) levels of isoflavones in the normal and malignant tissue of these organs in European and Asian populations; (3) average concentrations of isoflavones in the secretion of these organs (milk and semen). Finally, particular emphasis is placed on studies investigating the effect of isoflavones on tissues via estrogen receptors (ER).
PB  - MDPI
T2  - Antioxidants
T1  - The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer
VL  - 12
IS  - 2
SP  - 368
DO  - 10.3390/antiox12020368
ER  - 

@article{
author = "Pejčić, Tomislav and Zeković, Milica and Bumbaširević, Uroš and Kalaba, Milica and Vovk, Irena and Bensa, Maja and Popović, Lazar and Tešić, Živoslav Lj.",
year = "2023",
abstract = "This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms of action, and available data supporting the potential role of isoflavones in the prevention of breast cancer and prostate cancer are discussed. Studies evaluating the effects of isoflavones in tissue cultures of normal and malignant breast and prostate cells, as well as the current body of research regarding the effects of isoflavones attained through multiple modifications of cellular molecular signaling pathways and control of oxidative stress, are summarized. Furthermore, this review compiles literature sources reporting on the following: (1) levels of estrogen in breast and prostate tissue; (2) levels of isoflavones in the normal and malignant tissue of these organs in European and Asian populations; (3) average concentrations of isoflavones in the secretion of these organs (milk and semen). Finally, particular emphasis is placed on studies investigating the effect of isoflavones on tissues via estrogen receptors (ER).",
publisher = "MDPI",
journal = "Antioxidants",
title = "The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer",
volume = "12",
number = "2",
pages = "368",
doi = "10.3390/antiox12020368"
}

Pejčić, T., Zeković, M., Bumbaširević, U., Kalaba, M., Vovk, I., Bensa, M., Popović, L.,& Tešić, Ž. Lj.. (2023). The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer. in Antioxidants
MDPI., 12(2), 368.
https://doi.org/10.3390/antiox12020368

Pejčić T, Zeković M, Bumbaširević U, Kalaba M, Vovk I, Bensa M, Popović L, Tešić ŽL. The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer. in Antioxidants. 2023;12(2):368.
doi:10.3390/antiox12020368 .

Pejčić, Tomislav, Zeković, Milica, Bumbaširević, Uroš, Kalaba, Milica, Vovk, Irena, Bensa, Maja, Popović, Lazar, Tešić, Živoslav Lj., "The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer" in Antioxidants, 12, no. 2 (2023):368,
https://doi.org/10.3390/antiox12020368 . .

TY  - JOUR
AU  - Gašić, Uroš M.
AU  - Ćirić, Ivanka
AU  - Pejčić, Tomislav
AU  - Radenković, Dejan
AU  - Đorđević, Vladimir
AU  - Radulović, Siniša
AU  - Tešić, Živoslav Lj.
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4080
AB  - Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.
PB  - MDPI
T2  - Antioxidants
T1  - Polyphenols as Possible Agents for Pancreatic Diseases
VL  - 9
IS  - 6
SP  - 547
DO  - 10.3390/antiox9060547
ER  - 

@article{
author = "Gašić, Uroš M. and Ćirić, Ivanka and Pejčić, Tomislav and Radenković, Dejan and Đorđević, Vladimir and Radulović, Siniša and Tešić, Živoslav Lj.",
year = "2020",
abstract = "Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Polyphenols as Possible Agents for Pancreatic Diseases",
volume = "9",
number = "6",
pages = "547",
doi = "10.3390/antiox9060547"
}

Gašić, U. M., Ćirić, I., Pejčić, T., Radenković, D., Đorđević, V., Radulović, S.,& Tešić, Ž. Lj.. (2020). Polyphenols as Possible Agents for Pancreatic Diseases. in Antioxidants
MDPI., 9(6), 547.
https://doi.org/10.3390/antiox9060547

Gašić UM, Ćirić I, Pejčić T, Radenković D, Đorđević V, Radulović S, Tešić ŽL. Polyphenols as Possible Agents for Pancreatic Diseases. in Antioxidants. 2020;9(6):547.
doi:10.3390/antiox9060547 .

Gašić, Uroš M., Ćirić, Ivanka, Pejčić, Tomislav, Radenković, Dejan, Đorđević, Vladimir, Radulović, Siniša, Tešić, Živoslav Lj., "Polyphenols as Possible Agents for Pancreatic Diseases" in Antioxidants, 9, no. 6 (2020):547,
https://doi.org/10.3390/antiox9060547 . .

TY  - JOUR
AU  - Pejčić, Tomislav
AU  - Tosti, Tomislav
AU  - Džamić, Zoran
AU  - Gašić, Uroš M.
AU  - Vuksanović, Aleksandar
AU  - Dolićanin, Zana
AU  - Tešić, Živoslav Lj.
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3938
AB  - In recent years, the progress of science and medicine greatly has influenced human life
span and health. However, lifestyle habits, like physical activity, smoking cessation, moderate alcohol
consumption, diet, and maintaining a normal body weight represent measures that greatly reduce
the risk of various diseases. The type of diet is very important for disease development. Numerous
epidemiological clinical data confirm that longevity is linked to predominantly plant-based diets
and it is related to a long life; whereas the western diet, rich in red meat and fats, increases the risk
of oxidative stress and thus the risk of developing various diseases and pre-aging. This review is
focused on the bioavailability of polyphenols and the use of polyphenols for the prevention of prostate
diseases. Special focus in this paper is placed on the isoflavonoids and flavan-3-ols, subgroups of
polyphenols, and their protective e ects against the development of prostate diseases.
PB  - MDPI
T2  - Molecules
T1  - The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases
VL  - 24
IS  - 21
SP  - 3982
DO  - 10.3390/molecules24213982
ER  - 

@article{
author = "Pejčić, Tomislav and Tosti, Tomislav and Džamić, Zoran and Gašić, Uroš M. and Vuksanović, Aleksandar and Dolićanin, Zana and Tešić, Živoslav Lj.",
year = "2019",
abstract = "In recent years, the progress of science and medicine greatly has influenced human life
span and health. However, lifestyle habits, like physical activity, smoking cessation, moderate alcohol
consumption, diet, and maintaining a normal body weight represent measures that greatly reduce
the risk of various diseases. The type of diet is very important for disease development. Numerous
epidemiological clinical data confirm that longevity is linked to predominantly plant-based diets
and it is related to a long life; whereas the western diet, rich in red meat and fats, increases the risk
of oxidative stress and thus the risk of developing various diseases and pre-aging. This review is
focused on the bioavailability of polyphenols and the use of polyphenols for the prevention of prostate
diseases. Special focus in this paper is placed on the isoflavonoids and flavan-3-ols, subgroups of
polyphenols, and their protective e ects against the development of prostate diseases.",
publisher = "MDPI",
journal = "Molecules",
title = "The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases",
volume = "24",
number = "21",
pages = "3982",
doi = "10.3390/molecules24213982"
}

Pejčić, T., Tosti, T., Džamić, Z., Gašić, U. M., Vuksanović, A., Dolićanin, Z.,& Tešić, Ž. Lj.. (2019). The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases. in Molecules
MDPI., 24(21), 3982.
https://doi.org/10.3390/molecules24213982

Pejčić T, Tosti T, Džamić Z, Gašić UM, Vuksanović A, Dolićanin Z, Tešić ŽL. The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases. in Molecules. 2019;24(21):3982.
doi:10.3390/molecules24213982 .

Pejčić, Tomislav, Tosti, Tomislav, Džamić, Zoran, Gašić, Uroš M., Vuksanović, Aleksandar, Dolićanin, Zana, Tešić, Živoslav Lj., "The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases" in Molecules, 24, no. 21 (2019):3982,
https://doi.org/10.3390/molecules24213982 . .

TY  - JOUR
AU  - Pejčić, Tomislav
AU  - Tosti, Tomislav
AU  - Tešić, Živoslav Lj.
AU  - Milković, Borivoj
AU  - Dragičević, Dejan
AU  - Kozomara, Milutin
AU  - Čekerevac, Milica
AU  - Džamić, Zoran
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2479
AB  - BackgroundThere is still no consensus regarding intraprostatic androgen levels and the accumulation of androgens in the hyperplastic prostatic tissue. The current opinion is that intraprostatic dihydrotestosterone (DHT) concentrations are maintained but not elevated in benign prostatic hyperplasia (BPH), while there is no similar data concerning intraprostatic testosterone (T). MethodsTissue T (tT) and tissue DHT (tDHT) concentration were determined in 93 patients scheduled for initial prostate biopsy. The criteria for biopsy were abnormal DRE and/or PSA gt 4ng/mL. Total prostate volume (TPV) was determined by transrectal ultrasound (TRUS). During TRUS- guided prostate biopsy, 10-12 samples were collected from the peripheral zone (PZ) and two additional samples were collected from the transition zone (TZ). The samples from the TZ were immediately frozen in liquid nitrogen at -70 degrees C, and transported for tissue androgen determination, using liquid chromatography mass spectrometry (LC-MS). ResultsPathological analysis revealed that prostate cancer (PCa) was present in 45 and absent in 48 patients. In the whole group, there were 42 men with small prostate (TPV lt 30mL) and 51 with enlarged prostate (TPV31mL). The overall average tT level was 0.790.66ng/g, while the average tDHT level was 10.27 +/- 7.15ng/g. There were no differences in tT and tDHT level in prostates with and without PCa. However, tT and tDHT levels were significantly higher in larger, than in smaller prostates (tT: 1.05 +/- 0.75 and 0.46 +/- 0.29ng/g, and tDHT: 15.0 +/- 6.09 and 4.51 +/- 2.75ng/g, respectively). There were strong correlations between tT and TPV (r=0.71), and tDHT and TPV (r=0.74). ConclusionsThe present study confirmed that both T and DHT accumulated in the stroma of enlarged prostates; the degree of accumulation correlated with prostate volume.
PB  - Wiley, Hoboken
T2  - Prostate
T1  - Testosterone and dihydrotestosterone levels in the transition zone correlate with prostate volume
VL  - 77
IS  - 10
SP  - 1082
EP  - 1092
DO  - 10.1002/pros.23365
ER  - 

@article{
author = "Pejčić, Tomislav and Tosti, Tomislav and Tešić, Živoslav Lj. and Milković, Borivoj and Dragičević, Dejan and Kozomara, Milutin and Čekerevac, Milica and Džamić, Zoran",
year = "2017",
abstract = "BackgroundThere is still no consensus regarding intraprostatic androgen levels and the accumulation of androgens in the hyperplastic prostatic tissue. The current opinion is that intraprostatic dihydrotestosterone (DHT) concentrations are maintained but not elevated in benign prostatic hyperplasia (BPH), while there is no similar data concerning intraprostatic testosterone (T). MethodsTissue T (tT) and tissue DHT (tDHT) concentration were determined in 93 patients scheduled for initial prostate biopsy. The criteria for biopsy were abnormal DRE and/or PSA gt 4ng/mL. Total prostate volume (TPV) was determined by transrectal ultrasound (TRUS). During TRUS- guided prostate biopsy, 10-12 samples were collected from the peripheral zone (PZ) and two additional samples were collected from the transition zone (TZ). The samples from the TZ were immediately frozen in liquid nitrogen at -70 degrees C, and transported for tissue androgen determination, using liquid chromatography mass spectrometry (LC-MS). ResultsPathological analysis revealed that prostate cancer (PCa) was present in 45 and absent in 48 patients. In the whole group, there were 42 men with small prostate (TPV lt 30mL) and 51 with enlarged prostate (TPV31mL). The overall average tT level was 0.790.66ng/g, while the average tDHT level was 10.27 +/- 7.15ng/g. There were no differences in tT and tDHT level in prostates with and without PCa. However, tT and tDHT levels were significantly higher in larger, than in smaller prostates (tT: 1.05 +/- 0.75 and 0.46 +/- 0.29ng/g, and tDHT: 15.0 +/- 6.09 and 4.51 +/- 2.75ng/g, respectively). There were strong correlations between tT and TPV (r=0.71), and tDHT and TPV (r=0.74). ConclusionsThe present study confirmed that both T and DHT accumulated in the stroma of enlarged prostates; the degree of accumulation correlated with prostate volume.",
publisher = "Wiley, Hoboken",
journal = "Prostate",
title = "Testosterone and dihydrotestosterone levels in the transition zone correlate with prostate volume",
volume = "77",
number = "10",
pages = "1082-1092",
doi = "10.1002/pros.23365"
}

Pejčić, T., Tosti, T., Tešić, Ž. Lj., Milković, B., Dragičević, D., Kozomara, M., Čekerevac, M.,& Džamić, Z.. (2017). Testosterone and dihydrotestosterone levels in the transition zone correlate with prostate volume. in Prostate
Wiley, Hoboken., 77(10), 1082-1092.
https://doi.org/10.1002/pros.23365

Pejčić T, Tosti T, Tešić ŽL, Milković B, Dragičević D, Kozomara M, Čekerevac M, Džamić Z. Testosterone and dihydrotestosterone levels in the transition zone correlate with prostate volume. in Prostate. 2017;77(10):1082-1092.
doi:10.1002/pros.23365 .

Pejčić, Tomislav, Tosti, Tomislav, Tešić, Živoslav Lj., Milković, Borivoj, Dragičević, Dejan, Kozomara, Milutin, Čekerevac, Milica, Džamić, Zoran, "Testosterone and dihydrotestosterone levels in the transition zone correlate with prostate volume" in Prostate, 77, no. 10 (2017):1082-1092,
https://doi.org/10.1002/pros.23365 . .