@article{
author = "Opsenica, Igor and Smith, Kirsten K. and Gerena, Lucia and Gaica, Sandra and Šolaja, Bogdan A.",
year = "2008",
abstract = "Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds. The synthesized compounds showed pronounced antimalarial activity against Plasmodium falciparum chloroquine susceptible D6, chloroquine resistant W2 and multidrug-resistant TM91C235 (Thailand) strains. The aminoquinoline derivative 4 was more active against W2 and TM91C235 strains than the control compounds (CQ and MFQ)., U ovom radu prikazana je sinteza nekoliko ribofuranozidnih tetraoksana i 4-aminohinolina u cilju sagledavanja odnosa struktura-aktivnost ove vrste antimalarika. Jedinjenja su pokazala izraženu antimalarijsku aktivnost prema hlorokin-osetljivom (D6), hlorokin-rezistentnom (W2) i višestruko rezistentnom (TM91C235 (Thailand)) soju Plasmodium falciparum. Aminohinolinski derivat 4 je aktivniji prema W2 i TM91C235 sojevima od kontrolnih jedinjenja (hlorokin i meflokin).",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores, Ribofuranoza kao nosač tetraoksanske i 4-aminohinolinske antimalarijske farmakofore",
volume = "73",
number = "11",
pages = "1021-1025",
doi = "10.2298/JSC0811021O"
}