TY  - JOUR
AU  - Antić, Bratislav
AU  - Bošković, Marko
AU  - Nikodinović-Runić, Jasmina
AU  - Ming, Yue
AU  - Zhang, Hongguo
AU  - Bozin, Emil S.
AU  - Janković, Drina
AU  - Spasojević, Vojislav
AU  - Vranješ-Đurić, Sanja
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2453
AB  - Magnetic nanoparticles (MNPs) are of immense interest for diagnostic and therapeutic applications in medicine. Design and development of new iron oxide-based MNPs for such applications is of rather limited breadth without reliable and sensitive methods to determine their levels in body tissues. Commonly used methods, such as ICP, are quite problematic, due to the inability to decipher the origin of the detected iron, i.e. whether it originates from the MNPs or endogenous from tissues and bodily fluids. One of the approaches to overcome this problem and to increase reliability of tracing MNPs is to partially substitute iron ions in the MNPs with Er. Here, we report on the development of citric add coated (Fe,Er)(3)O-4 nanopartides and characterization of their physico-chemical and biological properties by utilization of various complementary approaches. The synthesized MNPs had a narrow (6-7 nm) size distribution, as consistently seen in atomic pair distribution function, transmission electron microscopy, and DC magnetization measurements. The particles were found to be superparamagnetic, with a pronounced maximum in measured zero-field cooled magnetization at around 90 K. Reduction in saturation magnetization due to incorporation of 1.7% Er3+ into the Fe3O4 matrix was clearly observed. From the biological standpoint, citric acid coated (Fe,Er)(3)O-4 NPs were found to induce low toxicity both in human cell fibroblasts and in zebrafish (Danio rerio) embryos. Biodistribution pattern of the MNPs after intravenous administration in healthy Wistar rats was followed by the radiotracer method, revealing that Y-90-labeled MNPs were predominantly found in liver (7533% ID), followed by lungs (16.70% ID) and spleen (2.83% ID). Quantitative agreement with these observations was obtained by ICP-MS elemental analysis using Er as the detected tracer. Based on the favorable physical, chemical and biological characteristics, citric add coated (Fe,Er)(3)O-4 MNPs could be further considered for the potential application as a diagnostic and/or therapeutic agent. This work also demonstrates that combined application of these techniques is a promising tool for studies of pharmacokinetics of the new MNPs in complex biological systems.
PB  - Elsevier Science Bv, Amsterdam
T2  - Materials Science and Engineering. C: Materials for Biological Applications
T1  - Complementary approaches for the evaluation of biocompatibility of Y-90-labeled superparamagnetic citric acid (Fe,Er)(3)O-4 coated nanoparticles
VL  - 75
SP  - 157
EP  - 164
DO  - 10.1016/j.msec.2017.02.023
ER  - 

@article{
author = "Antić, Bratislav and Bošković, Marko and Nikodinović-Runić, Jasmina and Ming, Yue and Zhang, Hongguo and Bozin, Emil S. and Janković, Drina and Spasojević, Vojislav and Vranješ-Đurić, Sanja",
year = "2017",
abstract = "Magnetic nanoparticles (MNPs) are of immense interest for diagnostic and therapeutic applications in medicine. Design and development of new iron oxide-based MNPs for such applications is of rather limited breadth without reliable and sensitive methods to determine their levels in body tissues. Commonly used methods, such as ICP, are quite problematic, due to the inability to decipher the origin of the detected iron, i.e. whether it originates from the MNPs or endogenous from tissues and bodily fluids. One of the approaches to overcome this problem and to increase reliability of tracing MNPs is to partially substitute iron ions in the MNPs with Er. Here, we report on the development of citric add coated (Fe,Er)(3)O-4 nanopartides and characterization of their physico-chemical and biological properties by utilization of various complementary approaches. The synthesized MNPs had a narrow (6-7 nm) size distribution, as consistently seen in atomic pair distribution function, transmission electron microscopy, and DC magnetization measurements. The particles were found to be superparamagnetic, with a pronounced maximum in measured zero-field cooled magnetization at around 90 K. Reduction in saturation magnetization due to incorporation of 1.7% Er3+ into the Fe3O4 matrix was clearly observed. From the biological standpoint, citric acid coated (Fe,Er)(3)O-4 NPs were found to induce low toxicity both in human cell fibroblasts and in zebrafish (Danio rerio) embryos. Biodistribution pattern of the MNPs after intravenous administration in healthy Wistar rats was followed by the radiotracer method, revealing that Y-90-labeled MNPs were predominantly found in liver (7533% ID), followed by lungs (16.70% ID) and spleen (2.83% ID). Quantitative agreement with these observations was obtained by ICP-MS elemental analysis using Er as the detected tracer. Based on the favorable physical, chemical and biological characteristics, citric add coated (Fe,Er)(3)O-4 MNPs could be further considered for the potential application as a diagnostic and/or therapeutic agent. This work also demonstrates that combined application of these techniques is a promising tool for studies of pharmacokinetics of the new MNPs in complex biological systems.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Materials Science and Engineering. C: Materials for Biological Applications",
title = "Complementary approaches for the evaluation of biocompatibility of Y-90-labeled superparamagnetic citric acid (Fe,Er)(3)O-4 coated nanoparticles",
volume = "75",
pages = "157-164",
doi = "10.1016/j.msec.2017.02.023"
}

Antić, B., Bošković, M., Nikodinović-Runić, J., Ming, Y., Zhang, H., Bozin, E. S., Janković, D., Spasojević, V.,& Vranješ-Đurić, S.. (2017). Complementary approaches for the evaluation of biocompatibility of Y-90-labeled superparamagnetic citric acid (Fe,Er)(3)O-4 coated nanoparticles. in Materials Science and Engineering. C: Materials for Biological Applications
Elsevier Science Bv, Amsterdam., 75, 157-164.
https://doi.org/10.1016/j.msec.2017.02.023

Antić B, Bošković M, Nikodinović-Runić J, Ming Y, Zhang H, Bozin ES, Janković D, Spasojević V, Vranješ-Đurić S. Complementary approaches for the evaluation of biocompatibility of Y-90-labeled superparamagnetic citric acid (Fe,Er)(3)O-4 coated nanoparticles. in Materials Science and Engineering. C: Materials for Biological Applications. 2017;75:157-164.
doi:10.1016/j.msec.2017.02.023 .

Antić, Bratislav, Bošković, Marko, Nikodinović-Runić, Jasmina, Ming, Yue, Zhang, Hongguo, Bozin, Emil S., Janković, Drina, Spasojević, Vojislav, Vranješ-Đurić, Sanja, "Complementary approaches for the evaluation of biocompatibility of Y-90-labeled superparamagnetic citric acid (Fe,Er)(3)O-4 coated nanoparticles" in Materials Science and Engineering. C: Materials for Biological Applications, 75 (2017):157-164,
https://doi.org/10.1016/j.msec.2017.02.023 . .