TY  - DATA
AU  - Živković, Marija
AU  - Kljun, Jakob
AU  - Ilić-Tomić, Tatjana
AU  - Pavić, Aleksandar
AU  - Veselinovic, A.
AU  - Manojlović, Dragan D.
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3144
PB  - Royal Soc Chemistry, Cambridge
T2  - INORGANIC CHEMISTRY FRONTIERS
T1  - Supplementary data for the article: Živković, M. D.; Kljun, J.; Ilic-Tomic, T.; Pavic, A.; Veselinović, A.; Manojlović, D. D.; Nikodinovic-Runic, J.; Turel, I. A New Class of Platinum(II) Complexes with the Phosphine Ligand Pta Which Show Potent Anticancer Activity. Inorganic Chemistry Frontiers 2018, 5 (1), 39–53. https://doi.org/10.1039/c7qi00299h
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3144
ER  - 

@misc{
author = "Živković, Marija and Kljun, Jakob and Ilić-Tomić, Tatjana and Pavić, Aleksandar and Veselinovic, A. and Manojlović, Dragan D. and Nikodinović-Runić, Jasmina and Turel, Iztok",
year = "2018",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "INORGANIC CHEMISTRY FRONTIERS",
title = "Supplementary data for the article: Živković, M. D.; Kljun, J.; Ilic-Tomic, T.; Pavic, A.; Veselinović, A.; Manojlović, D. D.; Nikodinovic-Runic, J.; Turel, I. A New Class of Platinum(II) Complexes with the Phosphine Ligand Pta Which Show Potent Anticancer Activity. Inorganic Chemistry Frontiers 2018, 5 (1), 39–53. https://doi.org/10.1039/c7qi00299h",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3144"
}

Živković, M., Kljun, J., Ilić-Tomić, T., Pavić, A., Veselinovic, A., Manojlović, D. D., Nikodinović-Runić, J.,& Turel, I.. (2018). Supplementary data for the article: Živković, M. D.; Kljun, J.; Ilic-Tomic, T.; Pavic, A.; Veselinović, A.; Manojlović, D. D.; Nikodinovic-Runic, J.; Turel, I. A New Class of Platinum(II) Complexes with the Phosphine Ligand Pta Which Show Potent Anticancer Activity. Inorganic Chemistry Frontiers 2018, 5 (1), 39–53. https://doi.org/10.1039/c7qi00299h. in INORGANIC CHEMISTRY FRONTIERS
Royal Soc Chemistry, Cambridge..
https://hdl.handle.net/21.15107/rcub_cherry_3144

Živković M, Kljun J, Ilić-Tomić T, Pavić A, Veselinovic A, Manojlović DD, Nikodinović-Runić J, Turel I. Supplementary data for the article: Živković, M. D.; Kljun, J.; Ilic-Tomic, T.; Pavic, A.; Veselinović, A.; Manojlović, D. D.; Nikodinovic-Runic, J.; Turel, I. A New Class of Platinum(II) Complexes with the Phosphine Ligand Pta Which Show Potent Anticancer Activity. Inorganic Chemistry Frontiers 2018, 5 (1), 39–53. https://doi.org/10.1039/c7qi00299h. in INORGANIC CHEMISTRY FRONTIERS. 2018;.
https://hdl.handle.net/21.15107/rcub_cherry_3144 .

Živković, Marija, Kljun, Jakob, Ilić-Tomić, Tatjana, Pavić, Aleksandar, Veselinovic, A., Manojlović, Dragan D., Nikodinović-Runić, Jasmina, Turel, Iztok, "Supplementary data for the article: Živković, M. D.; Kljun, J.; Ilic-Tomic, T.; Pavic, A.; Veselinović, A.; Manojlović, D. D.; Nikodinovic-Runic, J.; Turel, I. A New Class of Platinum(II) Complexes with the Phosphine Ligand Pta Which Show Potent Anticancer Activity. Inorganic Chemistry Frontiers 2018, 5 (1), 39–53. https://doi.org/10.1039/c7qi00299h" in INORGANIC CHEMISTRY FRONTIERS (2018),
https://hdl.handle.net/21.15107/rcub_cherry_3144 .

TY  - JOUR
AU  - Živković, Marija
AU  - Kljun, Jakob
AU  - Ilić-Tomić, Tatjana
AU  - Pavić, Aleksandar
AU  - Veselinovic, A.
AU  - Manojlović, Dragan D.
AU  - Nikodinović-Runić, Jasmina
AU  - Turel, Iztok
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2071
AB  - The anticancer potential of sixteen platinum(II) complexes with general formulae [PtCl(hq)(S-dmso)] (1a-8a) and [PtCl(hq)(pta)] (1b-8b) (where hq is 5-chloro-7-iodo-8-quinolinol (clioquinol; cqH) (1a, 1b), 8-hydroxy-5-nitroquinoline (nitroxoline; nxH) (2a, 2b), 5,7-dichloro-8-quinolinol (3a, 3b), 5,7-diiodo-8-quinolinol (4a, 4b), 5,7-dibromo-8-quinolinol (5a, 5b), 5,7-dichloro-8-hydroxy-2-methyl-quinoline (6a, 6b), 8-hydroxyquinoline (7a, 7b) and 8-quinolinethiol (8a, 8b); dmso is dimethyl sulfoxide and pta is 1,3,5triaza- 7-phosphaadamantane) was determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two carcinoma cell lines (A375 and A549) and embryotoxicity assay in a zebrafish model. Interactions with double stranded DNA through in vitro assay and a molecular docking study were examined. All complexes, except 6a, exhibited a high cytotoxic effect on MRC5 cells at a concentration of 10 mu g mL(-1) while 1b, 5a, 6a and 3b showed selective toxicity towards carcinoma cell lines. In general, pta-based complexes (series b) were more toxic according to the results of a MTT screen and the LC50 values obtained in zebrafish (Danio rerio) assay; they also induced higher oxidative stress in this model. Successful cellular uptake of complexes was shown by the ICP-MS methodology. The binding propensity of the complex with DNA obtained in in silico studies can be correlated with those from the experimental investigation. Compounds with the highest binding potential, according to the interaction energy value, were 1b, 3b, 6b and 5b. From observations of the DNA interaction ability and of the in silico assessment, no apparent DNA fragmentation was observed either on DNA extracted from the treated cancer cell line or from the zebrafish embryos.
PB  - Royal Soc Chemistry, Cambridge
T2  - INORGANIC CHEMISTRY FRONTIERS
T1  - A new class of platinum(II) complexes with the phosphine ligand pta which show potent anticancer activity
VL  - 5
IS  - 1
SP  - 39
EP  - 53
DO  - 10.1039/c7qi00299h
ER  - 

@article{
author = "Živković, Marija and Kljun, Jakob and Ilić-Tomić, Tatjana and Pavić, Aleksandar and Veselinovic, A. and Manojlović, Dragan D. and Nikodinović-Runić, Jasmina and Turel, Iztok",
year = "2018",
abstract = "The anticancer potential of sixteen platinum(II) complexes with general formulae [PtCl(hq)(S-dmso)] (1a-8a) and [PtCl(hq)(pta)] (1b-8b) (where hq is 5-chloro-7-iodo-8-quinolinol (clioquinol; cqH) (1a, 1b), 8-hydroxy-5-nitroquinoline (nitroxoline; nxH) (2a, 2b), 5,7-dichloro-8-quinolinol (3a, 3b), 5,7-diiodo-8-quinolinol (4a, 4b), 5,7-dibromo-8-quinolinol (5a, 5b), 5,7-dichloro-8-hydroxy-2-methyl-quinoline (6a, 6b), 8-hydroxyquinoline (7a, 7b) and 8-quinolinethiol (8a, 8b); dmso is dimethyl sulfoxide and pta is 1,3,5triaza- 7-phosphaadamantane) was determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two carcinoma cell lines (A375 and A549) and embryotoxicity assay in a zebrafish model. Interactions with double stranded DNA through in vitro assay and a molecular docking study were examined. All complexes, except 6a, exhibited a high cytotoxic effect on MRC5 cells at a concentration of 10 mu g mL(-1) while 1b, 5a, 6a and 3b showed selective toxicity towards carcinoma cell lines. In general, pta-based complexes (series b) were more toxic according to the results of a MTT screen and the LC50 values obtained in zebrafish (Danio rerio) assay; they also induced higher oxidative stress in this model. Successful cellular uptake of complexes was shown by the ICP-MS methodology. The binding propensity of the complex with DNA obtained in in silico studies can be correlated with those from the experimental investigation. Compounds with the highest binding potential, according to the interaction energy value, were 1b, 3b, 6b and 5b. From observations of the DNA interaction ability and of the in silico assessment, no apparent DNA fragmentation was observed either on DNA extracted from the treated cancer cell line or from the zebrafish embryos.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "INORGANIC CHEMISTRY FRONTIERS",
title = "A new class of platinum(II) complexes with the phosphine ligand pta which show potent anticancer activity",
volume = "5",
number = "1",
pages = "39-53",
doi = "10.1039/c7qi00299h"
}

Živković, M., Kljun, J., Ilić-Tomić, T., Pavić, A., Veselinovic, A., Manojlović, D. D., Nikodinović-Runić, J.,& Turel, I.. (2018). A new class of platinum(II) complexes with the phosphine ligand pta which show potent anticancer activity. in INORGANIC CHEMISTRY FRONTIERS
Royal Soc Chemistry, Cambridge., 5(1), 39-53.
https://doi.org/10.1039/c7qi00299h

Živković M, Kljun J, Ilić-Tomić T, Pavić A, Veselinovic A, Manojlović DD, Nikodinović-Runić J, Turel I. A new class of platinum(II) complexes with the phosphine ligand pta which show potent anticancer activity. in INORGANIC CHEMISTRY FRONTIERS. 2018;5(1):39-53.
doi:10.1039/c7qi00299h .

Živković, Marija, Kljun, Jakob, Ilić-Tomić, Tatjana, Pavić, Aleksandar, Veselinovic, A., Manojlović, Dragan D., Nikodinović-Runić, Jasmina, Turel, Iztok, "A new class of platinum(II) complexes with the phosphine ligand pta which show potent anticancer activity" in INORGANIC CHEMISTRY FRONTIERS, 5, no. 1 (2018):39-53,
https://doi.org/10.1039/c7qi00299h . .

TY  - DATA
AU  - Šenerović, Lidija
AU  - Živković, Marija
AU  - Veselinović, Aleksandar
AU  - Pavić, Aleksandar
AU  - Đuran, Miloš I.
AU  - Rajković, Snežana
AU  - Nikodinović-Runić, Jasmina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3440
PB  - Amer Chemical Soc, Washington
T2  - Journal of Medicinal Chemistry
T1  - Supplementary data for article: Senerovic, L.; Zivkovic, M. D.; Veselinovic, A.; Pavic, A.; Djuran, M. I.; Rajkovic, S.; Nikodinovic-Runic, J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. Journal of Medicinal Chemistry 2015, 58 (3), 1442–1451. https://doi.org/10.1021/jm5017686
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3440
ER  - 

@misc{
author = "Šenerović, Lidija and Živković, Marija and Veselinović, Aleksandar and Pavić, Aleksandar and Đuran, Miloš I. and Rajković, Snežana and Nikodinović-Runić, Jasmina",
year = "2015",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Medicinal Chemistry",
title = "Supplementary data for article: Senerovic, L.; Zivkovic, M. D.; Veselinovic, A.; Pavic, A.; Djuran, M. I.; Rajkovic, S.; Nikodinovic-Runic, J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. Journal of Medicinal Chemistry 2015, 58 (3), 1442–1451. https://doi.org/10.1021/jm5017686",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3440"
}

Šenerović, L., Živković, M., Veselinović, A., Pavić, A., Đuran, M. I., Rajković, S.,& Nikodinović-Runić, J.. (2015). Supplementary data for article: Senerovic, L.; Zivkovic, M. D.; Veselinovic, A.; Pavic, A.; Djuran, M. I.; Rajkovic, S.; Nikodinovic-Runic, J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. Journal of Medicinal Chemistry 2015, 58 (3), 1442–1451. https://doi.org/10.1021/jm5017686. in Journal of Medicinal Chemistry
Amer Chemical Soc, Washington..
https://hdl.handle.net/21.15107/rcub_cherry_3440

Šenerović L, Živković M, Veselinović A, Pavić A, Đuran MI, Rajković S, Nikodinović-Runić J. Supplementary data for article: Senerovic, L.; Zivkovic, M. D.; Veselinovic, A.; Pavic, A.; Djuran, M. I.; Rajkovic, S.; Nikodinovic-Runic, J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. Journal of Medicinal Chemistry 2015, 58 (3), 1442–1451. https://doi.org/10.1021/jm5017686. in Journal of Medicinal Chemistry. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3440 .

Šenerović, Lidija, Živković, Marija, Veselinović, Aleksandar, Pavić, Aleksandar, Đuran, Miloš I., Rajković, Snežana, Nikodinović-Runić, Jasmina, "Supplementary data for article: Senerovic, L.; Zivkovic, M. D.; Veselinovic, A.; Pavic, A.; Djuran, M. I.; Rajkovic, S.; Nikodinovic-Runic, J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. Journal of Medicinal Chemistry 2015, 58 (3), 1442–1451. https://doi.org/10.1021/jm5017686" in Journal of Medicinal Chemistry (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3440 .

TY  - JOUR
AU  - Živković, Marija
AU  - Jovasevic-Stojanovic, Milena
AU  - Cvetković, Anka
AU  - Lazovic, Ivan
AU  - Tasic, Visa
AU  - Stevanovic, Zana
AU  - Gržetić, Ivan
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1716
AB  - This study investigated seasonal variation of PAHs and their partition between gas and particulate-bounded phases in indoor and outdoor air in 4 schools In Serbia located at different locations. The sampling campaigns were conducted during one workweek at each school successively. Campaigns were conducted in schools during heating and non-heating seasons in December 2011 and June 2012. Seasonal variations of gas and particle-bounded PAHs concentrations were observed with higher levels during heating season. The highest total PAH values were associated with the gas phase in both sampling periods. The total PAHs concentration at indoor and at the outdoor sites, during heating season, ranged from 88.45 to 447.72 ng/m(3) and 201.69 to 1017.15 ng/m(3), respectively. During non-heating season, the total PAHs concentration ranged from 36.91 to 271.57 ng/m(3) in Indoor environment and 27.00 to 132.32 ng/m(3) in outdoor environment. Most of the I/O ratios were less than 1, which indicated that the indoor PAHs were mostly from outdoor sources. The use of diagnostic ratio showed that traffic emission and coal combustion are the major sources of PAHs. Only the diagnostic ratios for the school located near the industrial area showed significant deviation compared to other schools.
AB  - U ovom radu su istraživane sezonske promene PAH i njihova raspodela, u gasnoj fazi i respirabilnim česticama u vazduhu unutrašnjeg prostora i spoljašnje sredine u 4 škole u Srbiji koje se nalaze na različitim lokacijama. Kampanja uzorkovanja je sprovedena tokom jedne radne nedelje u toku grejnog i negrejnog perioda (od decembra 2011. do juna 2012.) u svakoj školi. Uočene su sezonske promene nivoa PAH u gasnoj fazi i česticama, sa višim koncentracijama tokom grejnog perioda. Izmerena je veća vrednost zbira ukupnih PAH tokom oba perioda u gasnoj fazi nego PAH u česticama. Ukupna koncentracija PAH tokom grejnog perioda u unutrašnjem prostoru se kretala u opsegu od 88,45 do 447,72 ng/m3, a u spoljašnjoj sredini od 201,69 do 1017,15 ng/m3. Tokom negrejnog perioda, ukupna koncentracija PAH-ova je bila 36,91-271,57 ng/m3 u unutrašnjem prostoru, dok je u spoljašnjoj sredini bila 27,00-132,32 ng/m3. Većina I/O odnosa je bila manja od 1, što ukazuje da PAH u unutrašnjem prostoru uglavnom potiču iz spoljašnjeg vazduha. Na osnovu dijagnostičkih odnosa zaključeno je da su saobraćaj i sagorevanje uglja glavni izvori PAH. Jedino dijagnostički odnosi za školu koja se nalazi u blizini industrijske zone pokazuju značajno odstupanje u poređenju sa drugim školama.
PB  - Assoc Chemical Eng, Belgrade
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - Pahs Levels in Gas and Particle-Bound Phase in Schools at Different Locations in Serbia
T1  - Nivo policikličnih aromatičnih ugljovodonika u gasnoj i čestičnoj fazi u školama na različitim lokacijama u Srbiji
VL  - 21
IS  - 1
SP  - 159
EP  - 167
DO  - 10.2298/CICEQ140206016Z
ER  - 

@article{
author = "Živković, Marija and Jovasevic-Stojanovic, Milena and Cvetković, Anka and Lazovic, Ivan and Tasic, Visa and Stevanovic, Zana and Gržetić, Ivan",
year = "2015",
abstract = "This study investigated seasonal variation of PAHs and their partition between gas and particulate-bounded phases in indoor and outdoor air in 4 schools In Serbia located at different locations. The sampling campaigns were conducted during one workweek at each school successively. Campaigns were conducted in schools during heating and non-heating seasons in December 2011 and June 2012. Seasonal variations of gas and particle-bounded PAHs concentrations were observed with higher levels during heating season. The highest total PAH values were associated with the gas phase in both sampling periods. The total PAHs concentration at indoor and at the outdoor sites, during heating season, ranged from 88.45 to 447.72 ng/m(3) and 201.69 to 1017.15 ng/m(3), respectively. During non-heating season, the total PAHs concentration ranged from 36.91 to 271.57 ng/m(3) in Indoor environment and 27.00 to 132.32 ng/m(3) in outdoor environment. Most of the I/O ratios were less than 1, which indicated that the indoor PAHs were mostly from outdoor sources. The use of diagnostic ratio showed that traffic emission and coal combustion are the major sources of PAHs. Only the diagnostic ratios for the school located near the industrial area showed significant deviation compared to other schools., U ovom radu su istraživane sezonske promene PAH i njihova raspodela, u gasnoj fazi i respirabilnim česticama u vazduhu unutrašnjeg prostora i spoljašnje sredine u 4 škole u Srbiji koje se nalaze na različitim lokacijama. Kampanja uzorkovanja je sprovedena tokom jedne radne nedelje u toku grejnog i negrejnog perioda (od decembra 2011. do juna 2012.) u svakoj školi. Uočene su sezonske promene nivoa PAH u gasnoj fazi i česticama, sa višim koncentracijama tokom grejnog perioda. Izmerena je veća vrednost zbira ukupnih PAH tokom oba perioda u gasnoj fazi nego PAH u česticama. Ukupna koncentracija PAH tokom grejnog perioda u unutrašnjem prostoru se kretala u opsegu od 88,45 do 447,72 ng/m3, a u spoljašnjoj sredini od 201,69 do 1017,15 ng/m3. Tokom negrejnog perioda, ukupna koncentracija PAH-ova je bila 36,91-271,57 ng/m3 u unutrašnjem prostoru, dok je u spoljašnjoj sredini bila 27,00-132,32 ng/m3. Većina I/O odnosa je bila manja od 1, što ukazuje da PAH u unutrašnjem prostoru uglavnom potiču iz spoljašnjeg vazduha. Na osnovu dijagnostičkih odnosa zaključeno je da su saobraćaj i sagorevanje uglja glavni izvori PAH. Jedino dijagnostički odnosi za školu koja se nalazi u blizini industrijske zone pokazuju značajno odstupanje u poređenju sa drugim školama.",
publisher = "Assoc Chemical Eng, Belgrade",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "Pahs Levels in Gas and Particle-Bound Phase in Schools at Different Locations in Serbia, Nivo policikličnih aromatičnih ugljovodonika u gasnoj i čestičnoj fazi u školama na različitim lokacijama u Srbiji",
volume = "21",
number = "1",
pages = "159-167",
doi = "10.2298/CICEQ140206016Z"
}

Živković, M., Jovasevic-Stojanovic, M., Cvetković, A., Lazovic, I., Tasic, V., Stevanovic, Z.,& Gržetić, I.. (2015). Pahs Levels in Gas and Particle-Bound Phase in Schools at Different Locations in Serbia. in Chemical Industry and Chemical Engineering Quarterly / CICEQ
Assoc Chemical Eng, Belgrade., 21(1), 159-167.
https://doi.org/10.2298/CICEQ140206016Z

Živković M, Jovasevic-Stojanovic M, Cvetković A, Lazovic I, Tasic V, Stevanovic Z, Gržetić I. Pahs Levels in Gas and Particle-Bound Phase in Schools at Different Locations in Serbia. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2015;21(1):159-167.
doi:10.2298/CICEQ140206016Z .

Živković, Marija, Jovasevic-Stojanovic, Milena, Cvetković, Anka, Lazovic, Ivan, Tasic, Visa, Stevanovic, Zana, Gržetić, Ivan, "Pahs Levels in Gas and Particle-Bound Phase in Schools at Different Locations in Serbia" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 21, no. 1 (2015):159-167,
https://doi.org/10.2298/CICEQ140206016Z . .

TY  - JOUR
AU  - Šenerović, Lidija
AU  - Živković, Marija
AU  - Veselinović, Aleksandar
AU  - Pavić, Aleksandar
AU  - Đuran, Miloš I.
AU  - Rajković, Snežana
AU  - Nikodinović-Runić, Jasmina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1659
AB  - Polynuclear Pt(II) complexes are a novel class of promising anticancer agents with potential clinical significance. A series of pyrazine (pz) bridged dinuclear Pt(II) complexes with general formulas {[Pt(L)Cl](2)(mu-pz)}(2+) (L, ethylenediamine, en; (+/-)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(+/-)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2-dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd) and one pyridazine (pydz) bridged {[Pt(en)Cl](2)(mu-pydz)}(2+) complex were prepared. The anticancer potential of these complexes were determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two carcinoma cell lines (A375 and HCT116), interaction with double stranded DNA through in vitro assay, and molecular docking study. All complexes inhibited cell proliferation with inhibitory concentrations in the 0.5-120 mu M range. While {[Pt(1,3-pd)Cl](2)(mu-pz)}(2+) showed improved activity and {[Pt(en)Cl](2)(mu-pydz)}(2+) showed comparable activity to that of clinically relevant cisplatin, {[Pt(en)Cl](2)(mu-pydz)}(2+) was less toxic in an assay with zebrafish (Danio rerio) embryos, causing no adverse developmental effects. The in vitro cytotoxicity of all diazine-bridged dinuclear Pt(II) complexes is discussed in correlation to their structural characteristics.
PB  - Amer Chemical Soc, Washington
T2  - Journal of Medicinal Chemistry
T1  - Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes
VL  - 58
IS  - 3
SP  - 1442
EP  - 1451
DO  - 10.1021/jm5017686
ER  - 

@article{
author = "Šenerović, Lidija and Živković, Marija and Veselinović, Aleksandar and Pavić, Aleksandar and Đuran, Miloš I. and Rajković, Snežana and Nikodinović-Runić, Jasmina",
year = "2015",
abstract = "Polynuclear Pt(II) complexes are a novel class of promising anticancer agents with potential clinical significance. A series of pyrazine (pz) bridged dinuclear Pt(II) complexes with general formulas {[Pt(L)Cl](2)(mu-pz)}(2+) (L, ethylenediamine, en; (+/-)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(+/-)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2-dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd) and one pyridazine (pydz) bridged {[Pt(en)Cl](2)(mu-pydz)}(2+) complex were prepared. The anticancer potential of these complexes were determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two carcinoma cell lines (A375 and HCT116), interaction with double stranded DNA through in vitro assay, and molecular docking study. All complexes inhibited cell proliferation with inhibitory concentrations in the 0.5-120 mu M range. While {[Pt(1,3-pd)Cl](2)(mu-pz)}(2+) showed improved activity and {[Pt(en)Cl](2)(mu-pydz)}(2+) showed comparable activity to that of clinically relevant cisplatin, {[Pt(en)Cl](2)(mu-pydz)}(2+) was less toxic in an assay with zebrafish (Danio rerio) embryos, causing no adverse developmental effects. The in vitro cytotoxicity of all diazine-bridged dinuclear Pt(II) complexes is discussed in correlation to their structural characteristics.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Medicinal Chemistry",
title = "Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes",
volume = "58",
number = "3",
pages = "1442-1451",
doi = "10.1021/jm5017686"
}

Šenerović, L., Živković, M., Veselinović, A., Pavić, A., Đuran, M. I., Rajković, S.,& Nikodinović-Runić, J.. (2015). Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. in Journal of Medicinal Chemistry
Amer Chemical Soc, Washington., 58(3), 1442-1451.
https://doi.org/10.1021/jm5017686

Šenerović L, Živković M, Veselinović A, Pavić A, Đuran MI, Rajković S, Nikodinović-Runić J. Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes. in Journal of Medicinal Chemistry. 2015;58(3):1442-1451.
doi:10.1021/jm5017686 .

Šenerović, Lidija, Živković, Marija, Veselinović, Aleksandar, Pavić, Aleksandar, Đuran, Miloš I., Rajković, Snežana, Nikodinović-Runić, Jasmina, "Synthesis and Evaluation of Series of Diazine-Bridged Dinuclear Platinum(II) Complexes through in Vitro Toxicity and Molecular Modeling: Correlation between Structure and Activity of Pt(II) Complexes" in Journal of Medicinal Chemistry, 58, no. 3 (2015):1442-1451,
https://doi.org/10.1021/jm5017686 . .

TY  - JOUR
AU  - Kovačević, Renata
AU  - Tasic, Visa
AU  - Živković, Marija
AU  - Živković, Nenad
AU  - Dordevic, Amelija
AU  - Manojlović, Dragan D.
AU  - Jovasevic-Stojanovic, Milena
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1715
AB  - Mass concentrations of particulate matter (PM) fractions were measured in educational buildings in the city of Nis, Serbia. Two sampling campaigns were conducted in winter periods. The first campaign was in the period from 21 February to 15 April 2010 at the Faculty of Occupational Safety (FOS) and the second campaign was from 20 March to 4 April 2013 at the primary school Void Karadorde (VK). PM measurements were carried out with low volume samplers Sven/Leckel LVS3. The average daily PM10 concentration inside the FOS (47.0 +/- 21.8 mu g/m(3)) was lower than PM10 concentration in outdoor air (50.7 +/- 28.1 mu g/m(3)). The average daily PM10 concentration inside the VK (54.6 +/- 17.6 mu g/m(3)) was higher than in outdoor air (47.9 +/- 22.8 mu g/m(3)). The 24-hours, average PM10 concentrations at FOS exceeded the EU limit value (50 mu g/m(3)) during 34% of days outdoors and 39% of days indoors. The 24-hours average PM10 concentrations at VK exceeded the limit value during 35% of days outdoors and 53% of days indoors. The 24-hours average PM2.5 concentrations at VK exceeded the WHO daily mean guideline value (25 mu g/m(3)) during 71% of days outdoors and 88% of days indoors. The average PM10 I/O ratio at VK was 1.57 during teaching hours, and 1.00 during no teaching hours. Similarly, average PM2.5 I/O ratio at VK was 1.11 during teaching hours and 0.90 during no teaching hours. Average daily PM2.5/PM10 ratio in the ambient air at VK was 0.87 and 0.82 at FOS. Very strong correlations between the indoor and outdoor PM concentrations were observed at VK during no teaching hours (r gt 0.8). Moderate to strong negative correlations were found between the wind speed and PM at both schools. High outdoor PM concentrations and resuspension of particles are possible reasons for the elevated indoor PM concentrations found in the study.
AB  - U radu su prikazani rezultati merenja suspendovanih čestica frakcija PM10 i PM2.5 u dve izabrane obrazovne ustanove u Nišu. Kampanje merenja sprovedene su u zimskom periodu. Prva u periodu od 21.02. do 15.04.2010. na Fakultetu zaštite na radu (FOS), a druga u periodu od 20.03. do 04.04.2013. u osnovnoj školi Vožd Karađorđe (VK). Uzorkovanje suspendovanih čestica vršeno je uzorkivačima Sven/Leckel LVS3, simultano, unutar i izvan odabranih ustanova. Prosečna dnevna koncentracija čestica PM10 unutar objekta FOS (47,0±21,8 μg/m3) bila je niža u odnosu na prosečnu dnevnu koncentraciju PM10 u ambijentalnom vazduhu (50,7±28,1 μg/m3). Prosečna dnevna koncentracija čestica PM10 unutar objekta VK (54.6±17.6 μg/m3) bila je viša u odnosu na prosečnu dnevnu koncentraciju PM10 u ambijentalnom vazduhu (47.9±22.8 μg/m3). Srednje dnevne koncentracije čestica PM10 izmerene na lokaciji FOS u ambijentalnom vazduhu prelazile su dnevnu graničnu vrednost (50 ìg/m3) tokom 34% dana trajanja kampanje merenja. Srednje dnevne koncentracije čestica PM10 izmerene unutar objekta FOS prelazile su dnevnu graničnu vrednost tokom 39% dana trajanja kampanje merenja. Srednje dnevne koncentracije čestica PM10 izmerene na lokaciji VK u ambijentalnom vazduhu prelazile su dnevnu graničnu vrednost tokom 35% dana trajanja kampanje merenja, odnosno tokom 53% dana trajanja kampanje u unutrašnjosti objekta VK. Srednje dnevne koncentracije čestica PM2,5 izmerene na lokaciji VK u ambijentalnom vazduhu prelazile su dnevnu graničnu vrednost (25 ìg/m3) tokom 71% dana trajanja kampanje, odnosno tokom 88% dana u unutrašnjosti objekta VK. Prosečan dnevni odnos unutra/spolja čestica frakcije PM10 na lokaciji VK iznosio je 1,57 u vreme nastave, odnosno 1,00 kada nije bilo nastave. Prosečan dnevni odnos unutra/spolja čestica frakcije PM2,5 na lokaciji VK iznosio je 1.11 u vreme nastave, odnosno 0.90 kada nije bilo nastave. Prosečan dnevni odnos PM2,5/PM10 u ambijentalnom vazduhu na lokaciji VK bio je 0,87, odnosno 0,82 na lokaciji FOS. Detektovana je veoma jaka korelacija između koncentracija suspendovanih čestica unutar i izvan objekta VK u periodu kada nije bilo nastave (r  gt  0.8). Umerena do jaka korelacija detektovana je između brzine vetra i koncentracija suspendovanih čestica na obe lokacije (FOS i VK). Visoke koncentracije suspendovanih čestica u ambijentalnom vazduhu i resuspenzija čestica najverovatniji su razlog koji utiče na povećane koncentracije suspendovanih čestica u unutrašnjem prostoru posmatranih obrazovnih ustanova.
PB  - Assoc Chemical Eng, Belgrade
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - Mass Concentrations and Indoor-Outdoor Relationships of Pm in Selected Educational Buildings in Nis, Serbia
T1  - Koncentracija suspendovanih čestica (PM10 I PM2.5) i njihov odnos unutra/spolja u odabranim obrazovnim ustanovama u Nišu
VL  - 21
IS  - 1
SP  - 149
EP  - 157
DO  - 10.2298/CICEQ140207013K
ER  - 

@article{
author = "Kovačević, Renata and Tasic, Visa and Živković, Marija and Živković, Nenad and Dordevic, Amelija and Manojlović, Dragan D. and Jovasevic-Stojanovic, Milena",
year = "2015",
abstract = "Mass concentrations of particulate matter (PM) fractions were measured in educational buildings in the city of Nis, Serbia. Two sampling campaigns were conducted in winter periods. The first campaign was in the period from 21 February to 15 April 2010 at the Faculty of Occupational Safety (FOS) and the second campaign was from 20 March to 4 April 2013 at the primary school Void Karadorde (VK). PM measurements were carried out with low volume samplers Sven/Leckel LVS3. The average daily PM10 concentration inside the FOS (47.0 +/- 21.8 mu g/m(3)) was lower than PM10 concentration in outdoor air (50.7 +/- 28.1 mu g/m(3)). The average daily PM10 concentration inside the VK (54.6 +/- 17.6 mu g/m(3)) was higher than in outdoor air (47.9 +/- 22.8 mu g/m(3)). The 24-hours, average PM10 concentrations at FOS exceeded the EU limit value (50 mu g/m(3)) during 34% of days outdoors and 39% of days indoors. The 24-hours average PM10 concentrations at VK exceeded the limit value during 35% of days outdoors and 53% of days indoors. The 24-hours average PM2.5 concentrations at VK exceeded the WHO daily mean guideline value (25 mu g/m(3)) during 71% of days outdoors and 88% of days indoors. The average PM10 I/O ratio at VK was 1.57 during teaching hours, and 1.00 during no teaching hours. Similarly, average PM2.5 I/O ratio at VK was 1.11 during teaching hours and 0.90 during no teaching hours. Average daily PM2.5/PM10 ratio in the ambient air at VK was 0.87 and 0.82 at FOS. Very strong correlations between the indoor and outdoor PM concentrations were observed at VK during no teaching hours (r gt 0.8). Moderate to strong negative correlations were found between the wind speed and PM at both schools. High outdoor PM concentrations and resuspension of particles are possible reasons for the elevated indoor PM concentrations found in the study., U radu su prikazani rezultati merenja suspendovanih čestica frakcija PM10 i PM2.5 u dve izabrane obrazovne ustanove u Nišu. Kampanje merenja sprovedene su u zimskom periodu. Prva u periodu od 21.02. do 15.04.2010. na Fakultetu zaštite na radu (FOS), a druga u periodu od 20.03. do 04.04.2013. u osnovnoj školi Vožd Karađorđe (VK). Uzorkovanje suspendovanih čestica vršeno je uzorkivačima Sven/Leckel LVS3, simultano, unutar i izvan odabranih ustanova. Prosečna dnevna koncentracija čestica PM10 unutar objekta FOS (47,0±21,8 μg/m3) bila je niža u odnosu na prosečnu dnevnu koncentraciju PM10 u ambijentalnom vazduhu (50,7±28,1 μg/m3). Prosečna dnevna koncentracija čestica PM10 unutar objekta VK (54.6±17.6 μg/m3) bila je viša u odnosu na prosečnu dnevnu koncentraciju PM10 u ambijentalnom vazduhu (47.9±22.8 μg/m3). Srednje dnevne koncentracije čestica PM10 izmerene na lokaciji FOS u ambijentalnom vazduhu prelazile su dnevnu graničnu vrednost (50 ìg/m3) tokom 34% dana trajanja kampanje merenja. Srednje dnevne koncentracije čestica PM10 izmerene unutar objekta FOS prelazile su dnevnu graničnu vrednost tokom 39% dana trajanja kampanje merenja. Srednje dnevne koncentracije čestica PM10 izmerene na lokaciji VK u ambijentalnom vazduhu prelazile su dnevnu graničnu vrednost tokom 35% dana trajanja kampanje merenja, odnosno tokom 53% dana trajanja kampanje u unutrašnjosti objekta VK. Srednje dnevne koncentracije čestica PM2,5 izmerene na lokaciji VK u ambijentalnom vazduhu prelazile su dnevnu graničnu vrednost (25 ìg/m3) tokom 71% dana trajanja kampanje, odnosno tokom 88% dana u unutrašnjosti objekta VK. Prosečan dnevni odnos unutra/spolja čestica frakcije PM10 na lokaciji VK iznosio je 1,57 u vreme nastave, odnosno 1,00 kada nije bilo nastave. Prosečan dnevni odnos unutra/spolja čestica frakcije PM2,5 na lokaciji VK iznosio je 1.11 u vreme nastave, odnosno 0.90 kada nije bilo nastave. Prosečan dnevni odnos PM2,5/PM10 u ambijentalnom vazduhu na lokaciji VK bio je 0,87, odnosno 0,82 na lokaciji FOS. Detektovana je veoma jaka korelacija između koncentracija suspendovanih čestica unutar i izvan objekta VK u periodu kada nije bilo nastave (r  gt  0.8). Umerena do jaka korelacija detektovana je između brzine vetra i koncentracija suspendovanih čestica na obe lokacije (FOS i VK). Visoke koncentracije suspendovanih čestica u ambijentalnom vazduhu i resuspenzija čestica najverovatniji su razlog koji utiče na povećane koncentracije suspendovanih čestica u unutrašnjem prostoru posmatranih obrazovnih ustanova.",
publisher = "Assoc Chemical Eng, Belgrade",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "Mass Concentrations and Indoor-Outdoor Relationships of Pm in Selected Educational Buildings in Nis, Serbia, Koncentracija suspendovanih čestica (PM10 I PM2.5) i njihov odnos unutra/spolja u odabranim obrazovnim ustanovama u Nišu",
volume = "21",
number = "1",
pages = "149-157",
doi = "10.2298/CICEQ140207013K"
}

Kovačević, R., Tasic, V., Živković, M., Živković, N., Dordevic, A., Manojlović, D. D.,& Jovasevic-Stojanovic, M.. (2015). Mass Concentrations and Indoor-Outdoor Relationships of Pm in Selected Educational Buildings in Nis, Serbia. in Chemical Industry and Chemical Engineering Quarterly / CICEQ
Assoc Chemical Eng, Belgrade., 21(1), 149-157.
https://doi.org/10.2298/CICEQ140207013K

Kovačević R, Tasic V, Živković M, Živković N, Dordevic A, Manojlović DD, Jovasevic-Stojanovic M. Mass Concentrations and Indoor-Outdoor Relationships of Pm in Selected Educational Buildings in Nis, Serbia. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2015;21(1):149-157.
doi:10.2298/CICEQ140207013K .

Kovačević, Renata, Tasic, Visa, Živković, Marija, Živković, Nenad, Dordevic, Amelija, Manojlović, Dragan D., Jovasevic-Stojanovic, Milena, "Mass Concentrations and Indoor-Outdoor Relationships of Pm in Selected Educational Buildings in Nis, Serbia" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 21, no. 1 (2015):149-157,
https://doi.org/10.2298/CICEQ140207013K . .