Milosavljević, Slobodan M.

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Authority KeyName Variants
9bd0541f-70b3-4d36-8556-0ed951eeb538
  • Milosavljević, Slobodan M. (91)
Projects
Natural products of wild, cultivated and edible plants: structure and bioactivity determination Sekundarni metaboliti samoniklih, lekovitih biljaka: izolovanje, karakterizacija i biloška aktivnost
Reinforcement of the Faculty of Chemistry, University of Belgrade, towards becoming a Center of Excellence in the region of WB for Molecular Biotechnology and Food research Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome
Ontogenetic characterization of phylogenetic biodiversity Microbial diversity study and characterization of beneficial environmental microorganisms
Biological response modifiers in physiological and pathological conditions Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima
Government of Montenegro, Secretariat for Development Biotechnology in vitro - crop, medicinal and endangered plant species
The effects of magnetic fields and other environmental stressors on the physiological responses and behavior of different species Micromorphological, phytochemical and molecular investigations of plants - systematic, ecological and applicative aspects
Characterization and application of fungal metabolites and assessment of new biofungicides potential Modulation of intracellular energy balance-controlling signalling pathways in therapy of cancer and neuro-immuno-endocrine disorders
Geography of Serbia Ispitivanje lekovitog potencijala biljaka: morfološka, hemijska i farmakološka karakterizacija
Taksonomska, biohemijska i molekularna istraživanja gljiva i biološki aktivnih supstanci Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima
Farmakodinamska i farmakogenetska istraživanja novih lekova i prediktivna/prognostička vrednost farmakoterapije u onkologiji Citotoksični, citoprotektivni i imunomodulatorni efekti nanočestica
Biljni proizvodi u preventivi i terapiji nezaraznih hroničnih oboljenja kod ljudi Matsumae International Foundation
Serbian Academy of Sciences and Arts [F-188]

Author's Bibliography

Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus

Cvetković, Mirjana; Damjanović, Ana; Stanojković, Tatjana; Đorđević, Iris; Tešević, Vele; Milosavljević, Slobodan M.; Gođevac, Dejan

(2020)

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Damjanović, Ana
AU  - Stanojković, Tatjana
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Gođevac, Dejan
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3348
AB  - Metabolomics generate a profile of small molecules from plant extracts, which could be directly responsible for bioactivity effects. Using dry-column flash chromatography enabled a rapid and inexpensive method for the very efficient separation of plant extract with a high resolution. This separation method coupled to NMR and FTIR-based metabolomics is applied to identify bioactive natural products. OPLS multivariate analysis method, was used for correlation the chemical composition of the plant extracts, Amphoricarpos autariatus, with the results of cytotoxic activity against Human cervical adenocarcinoma cell line (HeLa) and epithelial lung cancer cell line (A549). In this way, the highest contribution to the cytotoxic activity was recorded for the guaianolide sesquiterpene lactones named amphoricarpolides. The compounds indicated as bioactive after metabolomics analysis were tested, and their cytotoxic activity were confirmed.
T2  - Talanta
T1  - Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus
VL  - 206
SP  - 1
EP  - 6
DO  - 10.1016/j.talanta.2019.120248
ER  - 
@article{
author = "Cvetković, Mirjana and Damjanović, Ana and Stanojković, Tatjana and Đorđević, Iris and Tešević, Vele and Milosavljević, Slobodan M. and Gođevac, Dejan",
year = "2020",
abstract = "Metabolomics generate a profile of small molecules from plant extracts, which could be directly responsible for bioactivity effects. Using dry-column flash chromatography enabled a rapid and inexpensive method for the very efficient separation of plant extract with a high resolution. This separation method coupled to NMR and FTIR-based metabolomics is applied to identify bioactive natural products. OPLS multivariate analysis method, was used for correlation the chemical composition of the plant extracts, Amphoricarpos autariatus, with the results of cytotoxic activity against Human cervical adenocarcinoma cell line (HeLa) and epithelial lung cancer cell line (A549). In this way, the highest contribution to the cytotoxic activity was recorded for the guaianolide sesquiterpene lactones named amphoricarpolides. The compounds indicated as bioactive after metabolomics analysis were tested, and their cytotoxic activity were confirmed.",
journal = "Talanta",
title = "Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus",
volume = "206",
pages = "1-6",
doi = "10.1016/j.talanta.2019.120248"
}
Cvetković, M., Damjanović, A., Stanojković, T., Đorđević, I., Tešević, V., Milosavljević, S. M.,& Gođevac, D.. (2020). Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus. in Talanta, 206, 1-6.
https://doi.org/10.1016/j.talanta.2019.120248
Cvetković M, Damjanović A, Stanojković T, Đorđević I, Tešević V, Milosavljević SM, Gođevac D. Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus. in Talanta. 2020;206:1-6.
doi:10.1016/j.talanta.2019.120248 .
Cvetković, Mirjana, Damjanović, Ana, Stanojković, Tatjana, Đorđević, Iris, Tešević, Vele, Milosavljević, Slobodan M., Gođevac, Dejan, "Integration of dry-column flash chromatography with NMR and FTIR metabolomics to reveal cytotoxic metabolites from Amphoricarpos autariatus" in Talanta, 206 (2020):1-6,
https://doi.org/10.1016/j.talanta.2019.120248 . .
3
1
2

Supplementary material for the article: Cvetković, M.; Damjanović, A.; Stanojković, T. P.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. Integration of Dry-Column Flash Chromatography with NMR and FTIR Metabolomics to Reveal Cytotoxic Metabolites from Amphoricarpos Autariatus. Talanta 2020, 206. https://doi.org/10.1016/j.talanta.2019.120248

Cvetković, Mirjana; Damjanović, Ana; Stanojković, Tatjana; Đorđević, Iris; Tešević, Vele; Milosavljević, Slobodan M.; Gođevac, Dejan

(2020)

TY  - DATA
AU  - Cvetković, Mirjana
AU  - Damjanović, Ana
AU  - Stanojković, Tatjana
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Gođevac, Dejan
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3349
T2  - Talanta
T1  - Supplementary material for the article: Cvetković, M.; Damjanović, A.; Stanojković, T. P.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. Integration of Dry-Column Flash Chromatography with NMR and FTIR Metabolomics to Reveal Cytotoxic Metabolites from Amphoricarpos Autariatus. Talanta 2020, 206. https://doi.org/10.1016/j.talanta.2019.120248
ER  - 
@misc{
author = "Cvetković, Mirjana and Damjanović, Ana and Stanojković, Tatjana and Đorđević, Iris and Tešević, Vele and Milosavljević, Slobodan M. and Gođevac, Dejan",
year = "2020",
journal = "Talanta",
title = "Supplementary material for the article: Cvetković, M.; Damjanović, A.; Stanojković, T. P.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. Integration of Dry-Column Flash Chromatography with NMR and FTIR Metabolomics to Reveal Cytotoxic Metabolites from Amphoricarpos Autariatus. Talanta 2020, 206. https://doi.org/10.1016/j.talanta.2019.120248"
}
Cvetković, M., Damjanović, A., Stanojković, T., Đorđević, I., Tešević, V., Milosavljević, S. M.,& Gođevac, D.. (2020). Supplementary material for the article: Cvetković, M.; Damjanović, A.; Stanojković, T. P.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. Integration of Dry-Column Flash Chromatography with NMR and FTIR Metabolomics to Reveal Cytotoxic Metabolites from Amphoricarpos Autariatus. Talanta 2020, 206. https://doi.org/10.1016/j.talanta.2019.120248. in Talanta.
Cvetković M, Damjanović A, Stanojković T, Đorđević I, Tešević V, Milosavljević SM, Gođevac D. Supplementary material for the article: Cvetković, M.; Damjanović, A.; Stanojković, T. P.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. Integration of Dry-Column Flash Chromatography with NMR and FTIR Metabolomics to Reveal Cytotoxic Metabolites from Amphoricarpos Autariatus. Talanta 2020, 206. https://doi.org/10.1016/j.talanta.2019.120248. in Talanta. 2020;..
Cvetković, Mirjana, Damjanović, Ana, Stanojković, Tatjana, Đorđević, Iris, Tešević, Vele, Milosavljević, Slobodan M., Gođevac, Dejan, "Supplementary material for the article: Cvetković, M.; Damjanović, A.; Stanojković, T. P.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. Integration of Dry-Column Flash Chromatography with NMR and FTIR Metabolomics to Reveal Cytotoxic Metabolites from Amphoricarpos Autariatus. Talanta 2020, 206. https://doi.org/10.1016/j.talanta.2019.120248" in Talanta (2020).

NMR Spectroscopy in the Analysis of Illegal Drugs

Vajs, Vlatka; Đorđević, Iris; Vujisić, Ljubodrag V.; Milosavljević, Slobodan M.

(2018)

TY  - CHAP
AU  - Vajs, Vlatka
AU  - Đorđević, Iris
AU  - Vujisić, Ljubodrag V.
AU  - Milosavljević, Slobodan M.
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2841
AB  - The detection of illegal drugs in various samples has been among the most fascinating objects for the practicing analytical chemist involved in forensic analysis. For centuries (until the end of the nineteenth century), drugs were almost entirely of natural origin, mostly herbal, and in some cases slightly chemically modified (e.g., through acetylation of morphine to heroin). By the development of synthetic organic chemistry (commencing at the beginning of the twentieth century), quite a few synthetic drugs designed to mimic the pharmacological effects of drugs originating from natural sources have been designed (e.g., cannabimimetic indazole derivatives or amphetamines, etc.). Detection of such synthetic drugs, named “designer drugs,” due to a large number of new substances continuously emerging on the market, is crucial. The efficacy of this analysis has become a tremendous challenge in the analytical forensic field. A development of fast identification and structural characterization is greatly facilitated by the advent of modern spectroscopic techniques, namely nuclear magnetic resonance spectroscopy (NMR) and modern mass spectrometry (MS) as well as separation techniques, such as gas and liquid chromatography (GC and LC). Nowadays, rapid strategies for chemical characterizations of illicit drugs are available.
T2  - Chromatographic Techniques in the Forensic Analysis of Designer Drugs
T1  - NMR Spectroscopy in the Analysis of Illegal Drugs
SP  - 177
EP  - 197
DO  - 10.1201/9781315313177
ER  - 
@inbook{
author = "Vajs, Vlatka and Đorđević, Iris and Vujisić, Ljubodrag V. and Milosavljević, Slobodan M.",
year = "2018",
abstract = "The detection of illegal drugs in various samples has been among the most fascinating objects for the practicing analytical chemist involved in forensic analysis. For centuries (until the end of the nineteenth century), drugs were almost entirely of natural origin, mostly herbal, and in some cases slightly chemically modified (e.g., through acetylation of morphine to heroin). By the development of synthetic organic chemistry (commencing at the beginning of the twentieth century), quite a few synthetic drugs designed to mimic the pharmacological effects of drugs originating from natural sources have been designed (e.g., cannabimimetic indazole derivatives or amphetamines, etc.). Detection of such synthetic drugs, named “designer drugs,” due to a large number of new substances continuously emerging on the market, is crucial. The efficacy of this analysis has become a tremendous challenge in the analytical forensic field. A development of fast identification and structural characterization is greatly facilitated by the advent of modern spectroscopic techniques, namely nuclear magnetic resonance spectroscopy (NMR) and modern mass spectrometry (MS) as well as separation techniques, such as gas and liquid chromatography (GC and LC). Nowadays, rapid strategies for chemical characterizations of illicit drugs are available.",
journal = "Chromatographic Techniques in the Forensic Analysis of Designer Drugs",
booktitle = "NMR Spectroscopy in the Analysis of Illegal Drugs",
pages = "177-197",
doi = "10.1201/9781315313177"
}
Vajs, V., Đorđević, I., Vujisić, L. V.,& Milosavljević, S. M.. (2018). NMR Spectroscopy in the Analysis of Illegal Drugs. in Chromatographic Techniques in the Forensic Analysis of Designer Drugs, 177-197.
https://doi.org/10.1201/9781315313177
Vajs V, Đorđević I, Vujisić LV, Milosavljević SM. NMR Spectroscopy in the Analysis of Illegal Drugs. in Chromatographic Techniques in the Forensic Analysis of Designer Drugs. 2018;:177-197.
doi:10.1201/9781315313177 .
Vajs, Vlatka, Đorđević, Iris, Vujisić, Ljubodrag V., Milosavljević, Slobodan M., "NMR Spectroscopy in the Analysis of Illegal Drugs" in Chromatographic Techniques in the Forensic Analysis of Designer Drugs (2018):177-197,
https://doi.org/10.1201/9781315313177 . .
3

NMR-based metabolomics study of Amphoricarpos species from Montenegro

Cvetković, Mirjana; Anđelković, Boban D.; Stevanović, Vladimir; Jadranin, Milka; Đorđević, Iris; Tešević, Vele; Milosavljević, Slobodan M.; Gođevac, Dejan

(Elsevier Science Bv, Amsterdam, 2018)

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Anđelković, Boban D.
AU  - Stevanović, Vladimir
AU  - Jadranin, Milka
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Gođevac, Dejan
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2148
AB  - The genus Amphoricarpos Vis. is endemic of westpart of Balkan peninsula. In order to get more insight into the ambiguous taxonomy of the genus, the metabolomic study of the Amphoricarpos samples, has been undertaken. The(1)H NMR spectroscopy combined with multivariate data analysis has been applied. OPLS-DA has been shown to be the best method for clear discrimination of these samples based on the metabolites present in the extracts. The main difference between A. autariatus and A. neumayeri has been found to be the presence of characteristic sesquiterpene lactones of guaianolide type named amphoricarpolides. While the main sesquiterpene lactone in A. neumayeri was oxidized in position 2, those present in both subspecies of A. autariatus samples were oxidized in position 9. The use of sesquiterpene lactones as taxonomic characters for differentiating species of the Asteraceae family was reviewed elsewhere. For the differentiation of two subspecies, A. autariatus ssp. autariatus, and A. autariatus ssp. bertisceus, chlorogenic and malic acid have been found to be decisive, but these compounds do not have chemotaxonomic significance. Our results were in accordance with above mentioned classification of Blecic and Mayer but they differentiate from those of the recent genomic study of the genus indicating a single, genetically, morphologically and ecologically variable species, without intraspecific taxa.
PB  - Elsevier Science Bv, Amsterdam
T2  - Phytochemistry Letters
T1  - NMR-based metabolomics study of Amphoricarpos species from Montenegro
VL  - 25
SP  - 1
EP  - 5
DO  - 10.1016/j.phytol.2018.03.013
UR  - Kon_3479
ER  - 
@article{
author = "Cvetković, Mirjana and Anđelković, Boban D. and Stevanović, Vladimir and Jadranin, Milka and Đorđević, Iris and Tešević, Vele and Milosavljević, Slobodan M. and Gođevac, Dejan",
year = "2018",
abstract = "The genus Amphoricarpos Vis. is endemic of westpart of Balkan peninsula. In order to get more insight into the ambiguous taxonomy of the genus, the metabolomic study of the Amphoricarpos samples, has been undertaken. The(1)H NMR spectroscopy combined with multivariate data analysis has been applied. OPLS-DA has been shown to be the best method for clear discrimination of these samples based on the metabolites present in the extracts. The main difference between A. autariatus and A. neumayeri has been found to be the presence of characteristic sesquiterpene lactones of guaianolide type named amphoricarpolides. While the main sesquiterpene lactone in A. neumayeri was oxidized in position 2, those present in both subspecies of A. autariatus samples were oxidized in position 9. The use of sesquiterpene lactones as taxonomic characters for differentiating species of the Asteraceae family was reviewed elsewhere. For the differentiation of two subspecies, A. autariatus ssp. autariatus, and A. autariatus ssp. bertisceus, chlorogenic and malic acid have been found to be decisive, but these compounds do not have chemotaxonomic significance. Our results were in accordance with above mentioned classification of Blecic and Mayer but they differentiate from those of the recent genomic study of the genus indicating a single, genetically, morphologically and ecologically variable species, without intraspecific taxa.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Phytochemistry Letters",
title = "NMR-based metabolomics study of Amphoricarpos species from Montenegro",
volume = "25",
pages = "1-5",
doi = "10.1016/j.phytol.2018.03.013",
url = "Kon_3479"
}
Cvetković, M., Anđelković, B. D., Stevanović, V., Jadranin, M., Đorđević, I., Tešević, V., Milosavljević, S. M.,& Gođevac, D.. (2018). NMR-based metabolomics study of Amphoricarpos species from Montenegro. in Phytochemistry Letters
Elsevier Science Bv, Amsterdam., 25, 1-5.
https://doi.org/10.1016/j.phytol.2018.03.013
Kon_3479
Cvetković M, Anđelković BD, Stevanović V, Jadranin M, Đorđević I, Tešević V, Milosavljević SM, Gođevac D. NMR-based metabolomics study of Amphoricarpos species from Montenegro. in Phytochemistry Letters. 2018;25:1-5.
doi:10.1016/j.phytol.2018.03.013
Kon_3479 .
Cvetković, Mirjana, Anđelković, Boban D., Stevanović, Vladimir, Jadranin, Milka, Đorđević, Iris, Tešević, Vele, Milosavljević, Slobodan M., Gođevac, Dejan, "NMR-based metabolomics study of Amphoricarpos species from Montenegro" in Phytochemistry Letters, 25 (2018):1-5,
https://doi.org/10.1016/j.phytol.2018.03.013 .,
Kon_3479 .
1
1
1

Supplementary material for the article: Cvetković, M.; Anđelković, B.; Stevanović, V.; Jadranin, M.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. NMR-Based Metabolomics Study of Amphoricarpos Species from Montenegro. Phytochemistry Letters 2018, 25, 1–5. https://doi.org/10.1016/j.phytol.2018.03.013

Cvetković, Mirjana; Anđelković, Boban D.; Stevanović, Vladimir; Jadranin, Milka; Đorđević, Iris; Tešević, Vele; Milosavljević, Slobodan M.; Gođevac, Dejan

(Elsevier Science Bv, Amsterdam, 2018)

TY  - DATA
AU  - Cvetković, Mirjana
AU  - Anđelković, Boban D.
AU  - Stevanović, Vladimir
AU  - Jadranin, Milka
AU  - Đorđević, Iris
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Gođevac, Dejan
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3242
PB  - Elsevier Science Bv, Amsterdam
T2  - Phytochemistry Letters
T1  - Supplementary material for the article: Cvetković, M.; Anđelković, B.; Stevanović, V.; Jadranin, M.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. NMR-Based Metabolomics Study of Amphoricarpos Species from Montenegro. Phytochemistry Letters 2018, 25, 1–5. https://doi.org/10.1016/j.phytol.2018.03.013
ER  - 
@misc{
author = "Cvetković, Mirjana and Anđelković, Boban D. and Stevanović, Vladimir and Jadranin, Milka and Đorđević, Iris and Tešević, Vele and Milosavljević, Slobodan M. and Gođevac, Dejan",
year = "2018",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Phytochemistry Letters",
title = "Supplementary material for the article: Cvetković, M.; Anđelković, B.; Stevanović, V.; Jadranin, M.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. NMR-Based Metabolomics Study of Amphoricarpos Species from Montenegro. Phytochemistry Letters 2018, 25, 1–5. https://doi.org/10.1016/j.phytol.2018.03.013"
}
Cvetković, M., Anđelković, B. D., Stevanović, V., Jadranin, M., Đorđević, I., Tešević, V., Milosavljević, S. M.,& Gođevac, D.. (2018). Supplementary material for the article: Cvetković, M.; Anđelković, B.; Stevanović, V.; Jadranin, M.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. NMR-Based Metabolomics Study of Amphoricarpos Species from Montenegro. Phytochemistry Letters 2018, 25, 1–5. https://doi.org/10.1016/j.phytol.2018.03.013. in Phytochemistry Letters
Elsevier Science Bv, Amsterdam..
Cvetković M, Anđelković BD, Stevanović V, Jadranin M, Đorđević I, Tešević V, Milosavljević SM, Gođevac D. Supplementary material for the article: Cvetković, M.; Anđelković, B.; Stevanović, V.; Jadranin, M.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. NMR-Based Metabolomics Study of Amphoricarpos Species from Montenegro. Phytochemistry Letters 2018, 25, 1–5. https://doi.org/10.1016/j.phytol.2018.03.013. in Phytochemistry Letters. 2018;..
Cvetković, Mirjana, Anđelković, Boban D., Stevanović, Vladimir, Jadranin, Milka, Đorđević, Iris, Tešević, Vele, Milosavljević, Slobodan M., Gođevac, Dejan, "Supplementary material for the article: Cvetković, M.; Anđelković, B.; Stevanović, V.; Jadranin, M.; Đorđević, I.; Tešević, V.; Milosavljević, S.; Gođevac, D. NMR-Based Metabolomics Study of Amphoricarpos Species from Montenegro. Phytochemistry Letters 2018, 25, 1–5. https://doi.org/10.1016/j.phytol.2018.03.013" in Phytochemistry Letters (2018).

Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger

Novaković, Miroslav M.; Bukvicki, Danka; Vajs, Vlatka; Tešević, Vele; Milosavljević, Slobodan M.; Marin, Petar D.; Asakawa, Yoshinori

(Natural Products Inc, Westerville, 2018)

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Bukvicki, Danka
AU  - Vajs, Vlatka
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Marin, Petar D.
AU  - Asakawa, Yoshinori
PY  - 2018
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2150
AB  - A number of potentially useful compounds with various biological activities can be obtained from plant metabolites by microorganisms. In present research, essential oil of Calamintha glandulosa was subjected to the biotransformation process by mycromicete Aspergillus niger. GC/MS analyses of the original and biotransformed essential oil have revealed six(1-6) biotransformed compounds from one of the main component-limonene and one biotransformed product (7) originating from the less abundant component-thymol. Piperitone epoxide and piperitenone epoxide, the most abundant components of the original oil, were not biotransformed but gave three artefacts (A1, A2, B1) due to the acidic conditions formed in A. niger medium. Compounds 5, 6 as well as 7 have not been previously found as a biotransformation products of limonene (5 and 6) and thymol (7), respectively. New products (5, 6, and 7) together with the artefacts, were isolated by silica gel column chromatography followed by preparative silica gel thin layer chromatography, and their structures were established by a combination of 1D and 2D NMR spectra and GC/MS data. Biotransformation has one more confirmed as useful method, complementary to synthesis, for obtaining different type of molecules.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger
VL  - 13
IS  - 4
SP  - 479
EP  - 482
UR  - Kon_3481
ER  - 
@article{
author = "Novaković, Miroslav M. and Bukvicki, Danka and Vajs, Vlatka and Tešević, Vele and Milosavljević, Slobodan M. and Marin, Petar D. and Asakawa, Yoshinori",
year = "2018",
abstract = "A number of potentially useful compounds with various biological activities can be obtained from plant metabolites by microorganisms. In present research, essential oil of Calamintha glandulosa was subjected to the biotransformation process by mycromicete Aspergillus niger. GC/MS analyses of the original and biotransformed essential oil have revealed six(1-6) biotransformed compounds from one of the main component-limonene and one biotransformed product (7) originating from the less abundant component-thymol. Piperitone epoxide and piperitenone epoxide, the most abundant components of the original oil, were not biotransformed but gave three artefacts (A1, A2, B1) due to the acidic conditions formed in A. niger medium. Compounds 5, 6 as well as 7 have not been previously found as a biotransformation products of limonene (5 and 6) and thymol (7), respectively. New products (5, 6, and 7) together with the artefacts, were isolated by silica gel column chromatography followed by preparative silica gel thin layer chromatography, and their structures were established by a combination of 1D and 2D NMR spectra and GC/MS data. Biotransformation has one more confirmed as useful method, complementary to synthesis, for obtaining different type of molecules.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger",
volume = "13",
number = "4",
pages = "479-482",
url = "Kon_3481"
}
Novaković, M. M., Bukvicki, D., Vajs, V., Tešević, V., Milosavljević, S. M., Marin, P. D.,& Asakawa, Y.. (2018). Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger. in Natural Product Communications
Natural Products Inc, Westerville., 13(4), 479-482.
Kon_3481
Novaković MM, Bukvicki D, Vajs V, Tešević V, Milosavljević SM, Marin PD, Asakawa Y. Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger. in Natural Product Communications. 2018;13(4):479-482.
Kon_3481 .
Novaković, Miroslav M., Bukvicki, Danka, Vajs, Vlatka, Tešević, Vele, Milosavljević, Slobodan M., Marin, Petar D., Asakawa, Yoshinori, "Microbial Transformation of Calamintha glandulosa Essential Oil by Aspergillus niger" in Natural Product Communications, 13, no. 4 (2018):479-482,
Kon_3481 .
1
1

Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark

Novaković, Miroslav M.; Nikodinović-Runić, Jasmina; Veselinović, Jovana; Ilić-Tomić, Tatjana; Vidaković, Vera; Tešević, Vele; Milosavljević, Slobodan M.

(Amer Chemical Soc, Washington, 2017)

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Nikodinović-Runić, Jasmina
AU  - Veselinović, Jovana
AU  - Ilić-Tomić, Tatjana
AU  - Vidaković, Vera
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2466
AB  - Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation.
PB  - Amer Chemical Soc, Washington
T2  - Journal of Natural Products
T1  - Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark
VL  - 80
IS  - 5
SP  - 1255
EP  - 1263
DO  - 10.1021/acs.jnatprod.6b00805
UR  - Kon_3282
ER  - 
@article{
author = "Novaković, Miroslav M. and Nikodinović-Runić, Jasmina and Veselinović, Jovana and Ilić-Tomić, Tatjana and Vidaković, Vera and Tešević, Vele and Milosavljević, Slobodan M.",
year = "2017",
abstract = "Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of canter cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and Ha for an in silico investigation.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Natural Products",
title = "Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark",
volume = "80",
number = "5",
pages = "1255-1263",
doi = "10.1021/acs.jnatprod.6b00805",
url = "Kon_3282"
}
Novaković, M. M., Nikodinović-Runić, J., Veselinović, J., Ilić-Tomić, T., Vidaković, V., Tešević, V.,& Milosavljević, S. M.. (2017). Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark. in Journal of Natural Products
Amer Chemical Soc, Washington., 80(5), 1255-1263.
https://doi.org/10.1021/acs.jnatprod.6b00805
Kon_3282
Novaković MM, Nikodinović-Runić J, Veselinović J, Ilić-Tomić T, Vidaković V, Tešević V, Milosavljević SM. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark. in Journal of Natural Products. 2017;80(5):1255-1263.
doi:10.1021/acs.jnatprod.6b00805
Kon_3282 .
Novaković, Miroslav M., Nikodinović-Runić, Jasmina, Veselinović, Jovana, Ilić-Tomić, Tatjana, Vidaković, Vera, Tešević, Vele, Milosavljević, Slobodan M., "Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp viridis Bark" in Journal of Natural Products, 80, no. 5 (2017):1255-1263,
https://doi.org/10.1021/acs.jnatprod.6b00805 .,
Kon_3282 .
7
6
6

Supplementary data for article: Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805

Novaković, Miroslav M.; Nikodinović-Runić, Jasmina; Veselinović, Jovana; Ilić-Tomić, Tatjana; Vidaković, Vera; Tešević, Vele; Milosavljević, Slobodan M.

(Amer Chemical Soc, Washington, 2017)

TY  - DATA
AU  - Novaković, Miroslav M.
AU  - Nikodinović-Runić, Jasmina
AU  - Veselinović, Jovana
AU  - Ilić-Tomić, Tatjana
AU  - Vidaković, Vera
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3088
PB  - Amer Chemical Soc, Washington
T2  - Journal of Natural Products
T1  - Supplementary data for article:  Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805
ER  - 
@misc{
author = "Novaković, Miroslav M. and Nikodinović-Runić, Jasmina and Veselinović, Jovana and Ilić-Tomić, Tatjana and Vidaković, Vera and Tešević, Vele and Milosavljević, Slobodan M.",
year = "2017",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Natural Products",
title = "Supplementary data for article:  Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805"
}
Novaković, M. M., Nikodinović-Runić, J., Veselinović, J., Ilić-Tomić, T., Vidaković, V., Tešević, V.,& Milosavljević, S. M.. (2017). Supplementary data for article:  Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805. in Journal of Natural Products
Amer Chemical Soc, Washington..
Novaković MM, Nikodinović-Runić J, Veselinović J, Ilić-Tomić T, Vidaković V, Tešević V, Milosavljević SM. Supplementary data for article:  Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805. in Journal of Natural Products. 2017;..
Novaković, Miroslav M., Nikodinović-Runić, Jasmina, Veselinović, Jovana, Ilić-Tomić, Tatjana, Vidaković, Vera, Tešević, Vele, Milosavljević, Slobodan M., "Supplementary data for article:  Novakovic, M.; Nikodinovic-Runic, J.; Veselinovic, J.; Ilic-Tomic, T.; Vidakovic, V.; Tesevic, V.; Milosavljevic, S. Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus Viridis Ssp. Viridis Bark. Journal of Natural Products 2017, 80 (5), 1255–1263. https://doi.org/10.1021/acs.jnatprod.6b00805" in Journal of Natural Products (2017).

Artemisinin Story from the Balkans

Vajs, Vlatka; Jokić, Aleksandar; Milosavljević, Slobodan M.

(Natural Products Inc, Westerville, 2017)

TY  - JOUR
AU  - Vajs, Vlatka
AU  - Jokić, Aleksandar
AU  - Milosavljević, Slobodan M.
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2511
AB  - The isolation is reported of artemisinin (qinghaosu), a drug remarkably effective against malaria, from the aerial parts of Artemisia annua L. (sweet wormwood) at the Department of Chemistry, University of Belgrade (now Faculty of Chemistry), Serbia by the end of 1970, almost two years before the isolation of the same compound in China.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - Artemisinin Story from the Balkans
VL  - 12
IS  - 8
SP  - 1157
EP  - 1160
UR  - Kon_3327
ER  - 
@article{
author = "Vajs, Vlatka and Jokić, Aleksandar and Milosavljević, Slobodan M.",
year = "2017",
abstract = "The isolation is reported of artemisinin (qinghaosu), a drug remarkably effective against malaria, from the aerial parts of Artemisia annua L. (sweet wormwood) at the Department of Chemistry, University of Belgrade (now Faculty of Chemistry), Serbia by the end of 1970, almost two years before the isolation of the same compound in China.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "Artemisinin Story from the Balkans",
volume = "12",
number = "8",
pages = "1157-1160",
url = "Kon_3327"
}
Vajs, V., Jokić, A.,& Milosavljević, S. M.. (2017). Artemisinin Story from the Balkans. in Natural Product Communications
Natural Products Inc, Westerville., 12(8), 1157-1160.
Kon_3327
Vajs V, Jokić A, Milosavljević SM. Artemisinin Story from the Balkans. in Natural Product Communications. 2017;12(8):1157-1160.
Kon_3327 .
Vajs, Vlatka, Jokić, Aleksandar, Milosavljević, Slobodan M., "Artemisinin Story from the Balkans" in Natural Product Communications, 12, no. 8 (2017):1157-1160,
Kon_3327 .
1
1

Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929

Mandić, Boris; Vlajić, Marina D.; Trifunović, Snežana S.; Simić, Milena R.; Vujisić, Ljubodrag V.; Vučković, Ivan M.; Novaković, Miroslav M.; Nikolić-Mandić, Snežana D.; Tešević, Vele; Vajs, Vlatka; Milosavljević, Slobodan M.

(Taylor & Francis Ltd, Abingdon, 2015)

TY  - DATA
AU  - Mandić, Boris
AU  - Vlajić, Marina D.
AU  - Trifunović, Snežana S.
AU  - Simić, Milena R.
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan M.
AU  - Novaković, Miroslav M.
AU  - Nikolić-Mandić, Snežana D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3388
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929
ER  - 
@misc{
author = "Mandić, Boris and Vlajić, Marina D. and Trifunović, Snežana S. and Simić, Milena R. and Vujisić, Ljubodrag V. and Vučković, Ivan M. and Novaković, Miroslav M. and Nikolić-Mandić, Snežana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2015",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929"
}
Mandić, B., Vlajić, M. D., Trifunović, S. S., Simić, M. R., Vujisić, L. V., Vučković, I. M., Novaković, M. M., Nikolić-Mandić, S. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2015). Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929. in Natural Product Research
Taylor & Francis Ltd, Abingdon..
Mandić B, Vlajić MD, Trifunović SS, Simić MR, Vujisić LV, Vučković IM, Novaković MM, Nikolić-Mandić SD, Tešević V, Vajs V, Milosavljević SM. Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929. in Natural Product Research. 2015;..
Mandić, Boris, Vlajić, Marina D., Trifunović, Snežana S., Simić, Milena R., Vujisić, Ljubodrag V., Vučković, Ivan M., Novaković, Miroslav M., Nikolić-Mandić, Snežana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Supplementary data for article: Mandić, B. M.; Vlajić, M. D.; Trifunović, S. S.; Simić, M. R.; Vujisić, L. V.; Vučković, I. M.; Novaković, M. M.; Nikolić-Mandić, S. D.; Tešević, V. V.; Vajs, V. V.; et al. Optimisation of Isolation Procedure for Pyrrolizidine Alkaloids from Rindera Umbellata Bunge. Natural Product Research 2015, 29 (9), 887–890. https://doi.org/10.1080/14786419.2014.991929" in Natural Product Research (2015).

Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence

Vesović, Nikola; Ćurčić, Srećko; Vujisić, Ljubodrag V.; Nenadic, Marija; Krstić, Gordana B.; Peric-Mataruga, Vesna; Milosavljević, Slobodan M.; Antic, Dragan; Mandić, Boris; Petkovic, Matija; Vučković, Ivan M.; Marković, Đorđe; Vrbica, Maja; Ćurčić, Božidar; Makarov, Slobodan E.

(Springer, Dordrecht, 2015)

TY  - JOUR
AU  - Vesović, Nikola
AU  - Ćurčić, Srećko
AU  - Vujisić, Ljubodrag V.
AU  - Nenadic, Marija
AU  - Krstić, Gordana B.
AU  - Peric-Mataruga, Vesna
AU  - Milosavljević, Slobodan M.
AU  - Antic, Dragan
AU  - Mandić, Boris
AU  - Petkovic, Matija
AU  - Vučković, Ivan M.
AU  - Marković, Đorđe
AU  - Vrbica, Maja
AU  - Ćurčić, Božidar
AU  - Makarov, Slobodan E.
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1482
AB  - Three adult cave-dwelling ground beetle species were induced to discharge secretions of their pygidial glands into vials. Dichloromethane extraction was used to obtain the secretions. In total, 42 compounds were identified by GC/MS analysis. Pheggomisetes ninae contained 32 glandular compounds, Laemostenus (Pristonychus) punctatus 13, whereas Duvalius (Paraduvalius) milutini had nine compounds. Caproic, oleic, palmitic, and stearic acids were present in the samples of all analyzed species. Undecane was predominant in the extract of L. punctatus. Palmitic acid was the major component in the secretion of D. milutini. Finally, the most abundant compounds in P. ninae secretion were heptacosene and nonacosadienes. Herein, we present the first data on the identification of pygidial gland secretion components in both troglophilous and troglobite cave-dwelling ground beetles. Some compounds are reported for the first time in the secretions of ground beetles and other higher or lower taxa. The adaptation to underground life has not led to a reduction or changes in the chemical defense mechanism in the analyzed troglophilous and troglobitic Platyninae and Trechinae taxa.
PB  - Springer, Dordrecht
T2  - Journal of Chemical Ecology
T1  - Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence
VL  - 41
IS  - 6
SP  - 533
EP  - 539
DO  - 10.1007/s10886-015-0593-7
UR  - Kon_2602
ER  - 
@article{
author = "Vesović, Nikola and Ćurčić, Srećko and Vujisić, Ljubodrag V. and Nenadic, Marija and Krstić, Gordana B. and Peric-Mataruga, Vesna and Milosavljević, Slobodan M. and Antic, Dragan and Mandić, Boris and Petkovic, Matija and Vučković, Ivan M. and Marković, Đorđe and Vrbica, Maja and Ćurčić, Božidar and Makarov, Slobodan E.",
year = "2015",
abstract = "Three adult cave-dwelling ground beetle species were induced to discharge secretions of their pygidial glands into vials. Dichloromethane extraction was used to obtain the secretions. In total, 42 compounds were identified by GC/MS analysis. Pheggomisetes ninae contained 32 glandular compounds, Laemostenus (Pristonychus) punctatus 13, whereas Duvalius (Paraduvalius) milutini had nine compounds. Caproic, oleic, palmitic, and stearic acids were present in the samples of all analyzed species. Undecane was predominant in the extract of L. punctatus. Palmitic acid was the major component in the secretion of D. milutini. Finally, the most abundant compounds in P. ninae secretion were heptacosene and nonacosadienes. Herein, we present the first data on the identification of pygidial gland secretion components in both troglophilous and troglobite cave-dwelling ground beetles. Some compounds are reported for the first time in the secretions of ground beetles and other higher or lower taxa. The adaptation to underground life has not led to a reduction or changes in the chemical defense mechanism in the analyzed troglophilous and troglobitic Platyninae and Trechinae taxa.",
publisher = "Springer, Dordrecht",
journal = "Journal of Chemical Ecology",
title = "Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence",
volume = "41",
number = "6",
pages = "533-539",
doi = "10.1007/s10886-015-0593-7",
url = "Kon_2602"
}
Vesović, N., Ćurčić, S., Vujisić, L. V., Nenadic, M., Krstić, G. B., Peric-Mataruga, V., Milosavljević, S. M., Antic, D., Mandić, B., Petkovic, M., Vučković, I. M., Marković, Đ., Vrbica, M., Ćurčić, B.,& Makarov, S. E.. (2015). Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence. in Journal of Chemical Ecology
Springer, Dordrecht., 41(6), 533-539.
https://doi.org/10.1007/s10886-015-0593-7
Kon_2602
Vesović N, Ćurčić S, Vujisić LV, Nenadic M, Krstić GB, Peric-Mataruga V, Milosavljević SM, Antic D, Mandić B, Petkovic M, Vučković IM, Marković Đ, Vrbica M, Ćurčić B, Makarov SE. Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence. in Journal of Chemical Ecology. 2015;41(6):533-539.
doi:10.1007/s10886-015-0593-7
Kon_2602 .
Vesović, Nikola, Ćurčić, Srećko, Vujisić, Ljubodrag V., Nenadic, Marija, Krstić, Gordana B., Peric-Mataruga, Vesna, Milosavljević, Slobodan M., Antic, Dragan, Mandić, Boris, Petkovic, Matija, Vučković, Ivan M., Marković, Đorđe, Vrbica, Maja, Ćurčić, Božidar, Makarov, Slobodan E., "Molecular Diversity of Compounds from Pygidial Gland Secretions of Cave-Dwelling Ground Beetles: The First Evidence" in Journal of Chemical Ecology, 41, no. 6 (2015):533-539,
https://doi.org/10.1007/s10886-015-0593-7 .,
Kon_2602 .
3
11
10
10

Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge

Mandić, Boris; Vlajić, Marina D.; Trifunović, Snežana S.; Simić, Milena R.; Vujisić, Ljubodrag V.; Vučković, Ivan M.; Novaković, Miroslav M.; Nikolić-Mandić, Snežana D.; Tešević, Vele; Vajs, Vlatka; Milosavljević, Slobodan M.

(Taylor & Francis Ltd, Abingdon, 2015)

TY  - JOUR
AU  - Mandić, Boris
AU  - Vlajić, Marina D.
AU  - Trifunović, Snežana S.
AU  - Simić, Milena R.
AU  - Vujisić, Ljubodrag V.
AU  - Vučković, Ivan M.
AU  - Novaković, Miroslav M.
AU  - Nikolić-Mandić, Snežana D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1692
AB  - Procedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration and volume of sulphuric acid, pH of PA solution for alkaline extraction, extraction time and techniques (maceration, ultrasonic and overhead rotary mixer assisted extraction) were investigated. The yields of six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, 7-angeloyl rinderine, punctanecine and heliosupine) were monitored by GC-MS/FID. The best results for the isolation all of six PAs were obtained when the extraction was performed with 1M sulphuric acid (30mL per 1.00g of dried sample) by overhead rotary mixer during three days. Optimal pH value for alkaline extraction of PAs with CH2Cl2 was 9, and the extraction should be performed with four portions of 30mL of CH2Cl2. This procedure could be also useful for a plant sample preparation for GC and LC analyses of PAs.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge
VL  - 29
IS  - 9
SP  - 887
EP  - 890
DO  - 10.1080/14786419.2014.991929
UR  - Kon_2838
ER  - 
@article{
author = "Mandić, Boris and Vlajić, Marina D. and Trifunović, Snežana S. and Simić, Milena R. and Vujisić, Ljubodrag V. and Vučković, Ivan M. and Novaković, Miroslav M. and Nikolić-Mandić, Snežana D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2015",
abstract = "Procedure for isolation of pyrrolizidine alkaloids (PAs) from Rindera umbellata Bunge plant species was optimised. Different extraction media (methanol, ethanol and sulphuric acid), concentration and volume of sulphuric acid, pH of PA solution for alkaline extraction, extraction time and techniques (maceration, ultrasonic and overhead rotary mixer assisted extraction) were investigated. The yields of six PAs (7-angeloyl heliotridane, 7-angeloyl heliotridine, lindelofine, 7-angeloyl rinderine, punctanecine and heliosupine) were monitored by GC-MS/FID. The best results for the isolation all of six PAs were obtained when the extraction was performed with 1M sulphuric acid (30mL per 1.00g of dried sample) by overhead rotary mixer during three days. Optimal pH value for alkaline extraction of PAs with CH2Cl2 was 9, and the extraction should be performed with four portions of 30mL of CH2Cl2. This procedure could be also useful for a plant sample preparation for GC and LC analyses of PAs.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge",
volume = "29",
number = "9",
pages = "887-890",
doi = "10.1080/14786419.2014.991929",
url = "Kon_2838"
}
Mandić, B., Vlajić, M. D., Trifunović, S. S., Simić, M. R., Vujisić, L. V., Vučković, I. M., Novaković, M. M., Nikolić-Mandić, S. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2015). Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 29(9), 887-890.
https://doi.org/10.1080/14786419.2014.991929
Kon_2838
Mandić B, Vlajić MD, Trifunović SS, Simić MR, Vujisić LV, Vučković IM, Novaković MM, Nikolić-Mandić SD, Tešević V, Vajs V, Milosavljević SM. Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge. in Natural Product Research. 2015;29(9):887-890.
doi:10.1080/14786419.2014.991929
Kon_2838 .
Mandić, Boris, Vlajić, Marina D., Trifunović, Snežana S., Simić, Milena R., Vujisić, Ljubodrag V., Vučković, Ivan M., Novaković, Miroslav M., Nikolić-Mandić, Snežana D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Optimisation of isolation procedure for pyrrolizidine alkaloids from Rindera umbellata Bunge" in Natural Product Research, 29, no. 9 (2015):887-890,
https://doi.org/10.1080/14786419.2014.991929 .,
Kon_2838 .
7
6
6

Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae

Trifunović, Snežana S.; Isaković, Anđelka M.; Isaković, Aleksandra J.; Vučković, Ivan M.; Mandić, Boris; Novaković, Miroslav M.; Vajs, Vlatka; Milosavljević, Slobodan M.; Trajković, Vladimir S.

(Georg Thieme Verlag Kg, Stuttgart, 2014)

TY  - JOUR
AU  - Trifunović, Snežana S.
AU  - Isaković, Anđelka M.
AU  - Isaković, Aleksandra J.
AU  - Vučković, Ivan M.
AU  - Mandić, Boris
AU  - Novaković, Miroslav M.
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Trajković, Vladimir S.
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1511
AB  - Further phytochemical investigation of the aerial parts of Achillea clavennae has resulted in the isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and the iso-seco-guaianolide 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known compounds were also found, of which 9-acetoxycanin (5), sintenin (6), and oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were elucidated by combined spectroscopic methods (1D and 2DNMR, HRESIMS, CIMS, and FTIR). While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Planta Medica
T1  - Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae
VL  - 80
IS  - 4
SP  - 297
EP  - 305
DO  - 10.1055/s-0033-1360312
UR  - Kon_2631
ER  - 
@article{
author = "Trifunović, Snežana S. and Isaković, Anđelka M. and Isaković, Aleksandra J. and Vučković, Ivan M. and Mandić, Boris and Novaković, Miroslav M. and Vajs, Vlatka and Milosavljević, Slobodan M. and Trajković, Vladimir S.",
year = "2014",
abstract = "Further phytochemical investigation of the aerial parts of Achillea clavennae has resulted in the isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and the iso-seco-guaianolide 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known compounds were also found, of which 9-acetoxycanin (5), sintenin (6), and oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were elucidated by combined spectroscopic methods (1D and 2DNMR, HRESIMS, CIMS, and FTIR). While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae",
volume = "80",
number = "4",
pages = "297-305",
doi = "10.1055/s-0033-1360312",
url = "Kon_2631"
}
Trifunović, S. S., Isaković, A. M., Isaković, A. J., Vučković, I. M., Mandić, B., Novaković, M. M., Vajs, V., Milosavljević, S. M.,& Trajković, V. S.. (2014). Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 80(4), 297-305.
https://doi.org/10.1055/s-0033-1360312
Kon_2631
Trifunović SS, Isaković AM, Isaković AJ, Vučković IM, Mandić B, Novaković MM, Vajs V, Milosavljević SM, Trajković VS. Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae. in Planta Medica. 2014;80(4):297-305.
doi:10.1055/s-0033-1360312
Kon_2631 .
Trifunović, Snežana S., Isaković, Anđelka M., Isaković, Aleksandra J., Vučković, Ivan M., Mandić, Boris, Novaković, Miroslav M., Vajs, Vlatka, Milosavljević, Slobodan M., Trajković, Vladimir S., "Isolation, Characterization, and In Vitro Cytotoxicity of New Sesquiterpenoids from Achillea clavennae" in Planta Medica, 80, no. 4 (2014):297-305,
https://doi.org/10.1055/s-0033-1360312 .,
Kon_2631 .
6
4
5

Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection

Novaković, Miroslav M.; Stanković, Miroslava; Vučković, Ivan M.; Todorović, Nina; Trifunović, Snežana S.; Apostolović, Danijela; Mandić, Boris; Veljic, Milan; Marin, Petar D.; Tešević, Vele; Vajs, Vlatka; Milosavljević, Slobodan M.

(Wiley-V C H Verlag Gmbh, Weinheim, 2014)

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Stanković, Miroslava
AU  - Vučković, Ivan M.
AU  - Todorović, Nina
AU  - Trifunović, Snežana S.
AU  - Apostolović, Danijela
AU  - Mandić, Boris
AU  - Veljic, Milan
AU  - Marin, Petar D.
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1793
AB  - Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection
VL  - 11
IS  - 6
SP  - 872
EP  - 885
DO  - 10.1002/cbdv.201300277
UR  - Kon_2676
ER  - 
@article{
author = "Novaković, Miroslav M. and Stanković, Miroslava and Vučković, Ivan M. and Todorović, Nina and Trifunović, Snežana S. and Apostolović, Danijela and Mandić, Boris and Veljic, Milan and Marin, Petar D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2014",
abstract = "Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection",
volume = "11",
number = "6",
pages = "872-885",
doi = "10.1002/cbdv.201300277",
url = "Kon_2676"
}
Novaković, M. M., Stanković, M., Vučković, I. M., Todorović, N., Trifunović, S. S., Apostolović, D., Mandić, B., Veljic, M., Marin, P. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2014). Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(6), 872-885.
https://doi.org/10.1002/cbdv.201300277
Kon_2676
Novaković MM, Stanković M, Vučković IM, Todorović N, Trifunović SS, Apostolović D, Mandić B, Veljic M, Marin PD, Tešević V, Vajs V, Milosavljević SM. Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry and Biodiversity. 2014;11(6):872-885.
doi:10.1002/cbdv.201300277
Kon_2676 .
Novaković, Miroslav M., Stanković, Miroslava, Vučković, Ivan M., Todorović, Nina, Trifunović, Snežana S., Apostolović, Danijela, Mandić, Boris, Veljic, Milan, Marin, Petar D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection" in Chemistry and Biodiversity, 11, no. 6 (2014):872-885,
https://doi.org/10.1002/cbdv.201300277 .,
Kon_2676 .
6
7
7

Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae

Trifunović, Snežana S.; Isaković, Anđelka M.; Isaković, Aleksandra J.; Vučković, Ivan M.; Mandić, Boris; Novaković, Miroslav M.; Vajs, Vlatka; Milosavljević, Slobodan M.; Trajković, Vladimir S.

(Georg Thieme Verlag, 2014)

TY  - JOUR
AU  - Trifunović, Snežana S.
AU  - Isaković, Anđelka M.
AU  - Isaković, Aleksandra J.
AU  - Vučković, Ivan M.
AU  - Mandić, Boris
AU  - Novaković, Miroslav M.
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
AU  - Trajković, Vladimir S.
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2816
AB  - Further phytochemical investigation into the aerial parts of Achillea clavennae has resulted in the 3 
isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and 4 
the iso-seco-guaianolide, 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known 5 
compounds were also found in this plant species, of which 9 α -acetoxycanin (5), sintenin (6) and 6 
oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were 7 
elucidated by combined spectroscopic methods (1D and 2D NMR, HRESIMS, CIMS, FTIR). 8 
While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-9 
seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone 10 
apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.
PB  - Georg Thieme Verlag
T2  - Planta medica
T1  - Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae
VL  - 80
IS  - 4
SP  - 275
EP  - 305
DO  - 10.1055/s-0033-1360312
ER  - 
@article{
author = "Trifunović, Snežana S. and Isaković, Anđelka M. and Isaković, Aleksandra J. and Vučković, Ivan M. and Mandić, Boris and Novaković, Miroslav M. and Vajs, Vlatka and Milosavljević, Slobodan M. and Trajković, Vladimir S.",
year = "2014",
abstract = "Further phytochemical investigation into the aerial parts of Achillea clavennae has resulted in the 3 
isolation of three new sesquiterpene lactones: two highly oxygenated germacranolides (1, 2) and 4 
the iso-seco-guaianolide, 9(R)-acetoxy-3-O-methyl-iso-seco-tanapartholide (3). Eight known 5 
compounds were also found in this plant species, of which 9 α -acetoxycanin (5), sintenin (6) and 6 
oleanolic acid (7) were detected for the first time. The structures of the isolated compounds were 7 
elucidated by combined spectroscopic methods (1D and 2D NMR, HRESIMS, CIMS, FTIR). 8 
While the predominant metabolite germacranolide sintenin (6) was not cytotoxic, the new iso-9 
seco-guaianolide (3) displayed cytotoxicity comparable to that of cisplatin and the lactone 10 
apressin (4), inducing partly apoptotic death in human U251 and rat C6 glioma cell lines.",
publisher = "Georg Thieme Verlag",
journal = "Planta medica",
title = "Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae",
volume = "80",
number = "4",
pages = "275-305",
doi = "10.1055/s-0033-1360312"
}
Trifunović, S. S., Isaković, A. M., Isaković, A. J., Vučković, I. M., Mandić, B., Novaković, M. M., Vajs, V., Milosavljević, S. M.,& Trajković, V. S.. (2014). Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae. in Planta medica
Georg Thieme Verlag., 80(4), 275-305.
https://doi.org/10.1055/s-0033-1360312
Trifunović SS, Isaković AM, Isaković AJ, Vučković IM, Mandić B, Novaković MM, Vajs V, Milosavljević SM, Trajković VS. Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae. in Planta medica. 2014;80(4):275-305.
doi:10.1055/s-0033-1360312 .
Trifunović, Snežana S., Isaković, Anđelka M., Isaković, Aleksandra J., Vučković, Ivan M., Mandić, Boris, Novaković, Miroslav M., Vajs, Vlatka, Milosavljević, Slobodan M., Trajković, Vladimir S., "Isolation, characterization and in vitro cytotoxicity of new sesquiterpenoids from Achillea clavennae" in Planta medica, 80, no. 4 (2014):275-305,
https://doi.org/10.1055/s-0033-1360312 . .
6
4
5

Supplementary data for the article: Novaković, M.; Pešić, M.; Trifunović, S.; Vučković, I.; Todorović, N.; Podolski-Renić, A.; Dinić, J.; Stojković, S.; Tešević, V.; Vajs, V.; et al. Diarylheptanoids from the Bark of Black Alder Inhibit the Growth of Sensitive and Multi-Drug Resistant Non-Small Cell Lung Carcinoma Cells. Phytochemistry 2014, 97, 46–54. https://doi.org/10.1016/j.phytochem.2013.11.001

Novaković, Miroslav M.; Pešić, Milica; Trifunović, Snežana S.; Vučković, Ivan M.; Todorović, Nina; Podolski-Renić, Ana; Dinić, Jelena; Stojković, Sonja; Tešević, Vele; Vajs, Vlatka; Milosavljević, Slobodan M.

(Pergamon-Elsevier Science Ltd, Oxford, 2014)

TY  - DATA
AU  - Novaković, Miroslav M.
AU  - Pešić, Milica
AU  - Trifunović, Snežana S.
AU  - Vučković, Ivan M.
AU  - Todorović, Nina
AU  - Podolski-Renić, Ana
AU  - Dinić, Jelena
AU  - Stojković, Sonja
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3662
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Supplementary data for the article: Novaković, M.; Pešić, M.; Trifunović, S.; Vučković, I.; Todorović, N.; Podolski-Renić, A.; Dinić, J.; Stojković, S.; Tešević, V.; Vajs, V.; et al. Diarylheptanoids from the Bark of Black Alder Inhibit the Growth of Sensitive and Multi-Drug Resistant Non-Small Cell Lung Carcinoma Cells. Phytochemistry 2014, 97, 46–54. https://doi.org/10.1016/j.phytochem.2013.11.001
ER  - 
@misc{
author = "Novaković, Miroslav M. and Pešić, Milica and Trifunović, Snežana S. and Vučković, Ivan M. and Todorović, Nina and Podolski-Renić, Ana and Dinić, Jelena and Stojković, Sonja and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2014",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Supplementary data for the article: Novaković, M.; Pešić, M.; Trifunović, S.; Vučković, I.; Todorović, N.; Podolski-Renić, A.; Dinić, J.; Stojković, S.; Tešević, V.; Vajs, V.; et al. Diarylheptanoids from the Bark of Black Alder Inhibit the Growth of Sensitive and Multi-Drug Resistant Non-Small Cell Lung Carcinoma Cells. Phytochemistry 2014, 97, 46–54. https://doi.org/10.1016/j.phytochem.2013.11.001"
}
Novaković, M. M., Pešić, M., Trifunović, S. S., Vučković, I. M., Todorović, N., Podolski-Renić, A., Dinić, J., Stojković, S., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2014). Supplementary data for the article: Novaković, M.; Pešić, M.; Trifunović, S.; Vučković, I.; Todorović, N.; Podolski-Renić, A.; Dinić, J.; Stojković, S.; Tešević, V.; Vajs, V.; et al. Diarylheptanoids from the Bark of Black Alder Inhibit the Growth of Sensitive and Multi-Drug Resistant Non-Small Cell Lung Carcinoma Cells. Phytochemistry 2014, 97, 46–54. https://doi.org/10.1016/j.phytochem.2013.11.001. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford..
Novaković MM, Pešić M, Trifunović SS, Vučković IM, Todorović N, Podolski-Renić A, Dinić J, Stojković S, Tešević V, Vajs V, Milosavljević SM. Supplementary data for the article: Novaković, M.; Pešić, M.; Trifunović, S.; Vučković, I.; Todorović, N.; Podolski-Renić, A.; Dinić, J.; Stojković, S.; Tešević, V.; Vajs, V.; et al. Diarylheptanoids from the Bark of Black Alder Inhibit the Growth of Sensitive and Multi-Drug Resistant Non-Small Cell Lung Carcinoma Cells. Phytochemistry 2014, 97, 46–54. https://doi.org/10.1016/j.phytochem.2013.11.001. in Phytochemistry. 2014;..
Novaković, Miroslav M., Pešić, Milica, Trifunović, Snežana S., Vučković, Ivan M., Todorović, Nina, Podolski-Renić, Ana, Dinić, Jelena, Stojković, Sonja, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Supplementary data for the article: Novaković, M.; Pešić, M.; Trifunović, S.; Vučković, I.; Todorović, N.; Podolski-Renić, A.; Dinić, J.; Stojković, S.; Tešević, V.; Vajs, V.; et al. Diarylheptanoids from the Bark of Black Alder Inhibit the Growth of Sensitive and Multi-Drug Resistant Non-Small Cell Lung Carcinoma Cells. Phytochemistry 2014, 97, 46–54. https://doi.org/10.1016/j.phytochem.2013.11.001" in Phytochemistry (2014).

Defensive secretions in three ground-beetle species (Insecta: Coleoptera: Carabidae)

Lecic, Sonja; Ćurčić, Srećko; Vujisić, Ljubodrag V.; Ćurčić, Božidar; Ćurčić, Nina; Nikolic, Zoran; Anđelković, Boban D.; Milosavljević, Slobodan M.; Tešević, Vele; Makarov, Slobodan E.

(Finnish Zoological Botanical Publishing Board, Univ Helsinki, 2014)

TY  - JOUR
AU  - Lecic, Sonja
AU  - Ćurčić, Srećko
AU  - Vujisić, Ljubodrag V.
AU  - Ćurčić, Božidar
AU  - Ćurčić, Nina
AU  - Nikolic, Zoran
AU  - Anđelković, Boban D.
AU  - Milosavljević, Slobodan M.
AU  - Tešević, Vele
AU  - Makarov, Slobodan E.
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1803
AB  - The adults of three ground-beetle species were induced to discharge defensive secretions into vials. The secretions were obtained by CH2C12 extraction. Altogether 11 compounds were identified by GC-MS analysis. Calosoma sycophanta possesses 10 defensive compounds, Carabus ullrichii seven, while Abax parallelepipedus has six compounds. Methacrylic, tiglic and isobutyric acids were present in all samples. The first two organic compounds were predominant in the extracts of Abax parallelepipedus. Methacrylic acid and salicylaldehyde were the major compounds in extracts of Calosoma sycophanta. Methacrylic and angelic acids were the major components in extracts of Carabus ullrichii. Propanoic acid was detected for the first time in the family Carabidae and in all animals. 2-Methyl butyric, angelic and benzoic acids were found for the first time in the subfamily Carabinae. Our finding of butyric acid is its first precise identification in the Carabinae subfamily. 2-Methyl butyric, angelic, crotonic, senecioic and benzoic acids were found for the first time in a European groundbeetle species. The compounds detected in the defensive secretions serve as protection against predators.
PB  - Finnish Zoological Botanical Publishing Board, Univ Helsinki
T2  - Annales Zoologici Fennici
T1  - Defensive secretions in three ground-beetle species (Insecta: Coleoptera: Carabidae)
VL  - 51
IS  - 3
SP  - 285
EP  - 300
UR  - Kon_2686
ER  - 
@article{
author = "Lecic, Sonja and Ćurčić, Srećko and Vujisić, Ljubodrag V. and Ćurčić, Božidar and Ćurčić, Nina and Nikolic, Zoran and Anđelković, Boban D. and Milosavljević, Slobodan M. and Tešević, Vele and Makarov, Slobodan E.",
year = "2014",
abstract = "The adults of three ground-beetle species were induced to discharge defensive secretions into vials. The secretions were obtained by CH2C12 extraction. Altogether 11 compounds were identified by GC-MS analysis. Calosoma sycophanta possesses 10 defensive compounds, Carabus ullrichii seven, while Abax parallelepipedus has six compounds. Methacrylic, tiglic and isobutyric acids were present in all samples. The first two organic compounds were predominant in the extracts of Abax parallelepipedus. Methacrylic acid and salicylaldehyde were the major compounds in extracts of Calosoma sycophanta. Methacrylic and angelic acids were the major components in extracts of Carabus ullrichii. Propanoic acid was detected for the first time in the family Carabidae and in all animals. 2-Methyl butyric, angelic and benzoic acids were found for the first time in the subfamily Carabinae. Our finding of butyric acid is its first precise identification in the Carabinae subfamily. 2-Methyl butyric, angelic, crotonic, senecioic and benzoic acids were found for the first time in a European groundbeetle species. The compounds detected in the defensive secretions serve as protection against predators.",
publisher = "Finnish Zoological Botanical Publishing Board, Univ Helsinki",
journal = "Annales Zoologici Fennici",
title = "Defensive secretions in three ground-beetle species (Insecta: Coleoptera: Carabidae)",
volume = "51",
number = "3",
pages = "285-300",
url = "Kon_2686"
}
Lecic, S., Ćurčić, S., Vujisić, L. V., Ćurčić, B., Ćurčić, N., Nikolic, Z., Anđelković, B. D., Milosavljević, S. M., Tešević, V.,& Makarov, S. E.. (2014). Defensive secretions in three ground-beetle species (Insecta: Coleoptera: Carabidae). in Annales Zoologici Fennici
Finnish Zoological Botanical Publishing Board, Univ Helsinki., 51(3), 285-300.
Kon_2686
Lecic S, Ćurčić S, Vujisić LV, Ćurčić B, Ćurčić N, Nikolic Z, Anđelković BD, Milosavljević SM, Tešević V, Makarov SE. Defensive secretions in three ground-beetle species (Insecta: Coleoptera: Carabidae). in Annales Zoologici Fennici. 2014;51(3):285-300.
Kon_2686 .
Lecic, Sonja, Ćurčić, Srećko, Vujisić, Ljubodrag V., Ćurčić, Božidar, Ćurčić, Nina, Nikolic, Zoran, Anđelković, Boban D., Milosavljević, Slobodan M., Tešević, Vele, Makarov, Slobodan E., "Defensive secretions in three ground-beetle species (Insecta: Coleoptera: Carabidae)" in Annales Zoologici Fennici, 51, no. 3 (2014):285-300,
Kon_2686 .
15
18

Volatile Constituents of Different Plant Parts and Populations of Malabaila aurea Boiss. from Montenegro

Vučković, Ivan M.; Vujisić, Ljubodrag V.; Todosijević, Marina; Stesevic, Danijela; Milosavljević, Slobodan M.; Trifunović, Snežana S.

(Acg Publications, Gebze-Kocaeli, 2014)

TY  - JOUR
AU  - Vučković, Ivan M.
AU  - Vujisić, Ljubodrag V.
AU  - Todosijević, Marina
AU  - Stesevic, Danijela
AU  - Milosavljević, Slobodan M.
AU  - Trifunović, Snežana S.
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1775
AB  - The volatile constituents of different plant parts and populations of Malabaila aurea Boiss. from Montenegro were obtained by simultaneous distillation-extraction and analyzed by GC-FID and GC-MS. A total of 12 samples were examined and 45 compounds were identified. The volatile content of different M. aurea populations was very similar, while the volatile fractions obtained from different plant parts showed significant qualitative and quantitative differences. The most abundant compounds found in stems & leaves were apiole (51.0-56.3%), myristicin (16.3-25.4%), and falcarinol (4.1-10.7%). The roots showed the same major components, but with different relative abundances: 30.9-49.1% of apiole, 12.9-34.7% of falcarinol, and 9.9-31.1% of myristicin. The volatile constituents of fruits & flowers were remarkably different, containing up to 71.2-80.5% octyl butyrate, 11.4-18.0% octanol, and 2.7-6.8% octyl hexanoate. The results were discussed as possible indication of relatedness of Malabaila aurea and Pastinaca sativa (parsnip).
PB  - Acg Publications, Gebze-Kocaeli
T2  - Records of Natural Products
T1  - Volatile Constituents of Different Plant Parts and Populations of Malabaila aurea Boiss. from Montenegro
VL  - 8
IS  - 2
SP  - 148
EP  - 155
UR  - Kon_2658
ER  - 
@article{
author = "Vučković, Ivan M. and Vujisić, Ljubodrag V. and Todosijević, Marina and Stesevic, Danijela and Milosavljević, Slobodan M. and Trifunović, Snežana S.",
year = "2014",
abstract = "The volatile constituents of different plant parts and populations of Malabaila aurea Boiss. from Montenegro were obtained by simultaneous distillation-extraction and analyzed by GC-FID and GC-MS. A total of 12 samples were examined and 45 compounds were identified. The volatile content of different M. aurea populations was very similar, while the volatile fractions obtained from different plant parts showed significant qualitative and quantitative differences. The most abundant compounds found in stems & leaves were apiole (51.0-56.3%), myristicin (16.3-25.4%), and falcarinol (4.1-10.7%). The roots showed the same major components, but with different relative abundances: 30.9-49.1% of apiole, 12.9-34.7% of falcarinol, and 9.9-31.1% of myristicin. The volatile constituents of fruits & flowers were remarkably different, containing up to 71.2-80.5% octyl butyrate, 11.4-18.0% octanol, and 2.7-6.8% octyl hexanoate. The results were discussed as possible indication of relatedness of Malabaila aurea and Pastinaca sativa (parsnip).",
publisher = "Acg Publications, Gebze-Kocaeli",
journal = "Records of Natural Products",
title = "Volatile Constituents of Different Plant Parts and Populations of Malabaila aurea Boiss. from Montenegro",
volume = "8",
number = "2",
pages = "148-155",
url = "Kon_2658"
}
Vučković, I. M., Vujisić, L. V., Todosijević, M., Stesevic, D., Milosavljević, S. M.,& Trifunović, S. S.. (2014). Volatile Constituents of Different Plant Parts and Populations of Malabaila aurea Boiss. from Montenegro. in Records of Natural Products
Acg Publications, Gebze-Kocaeli., 8(2), 148-155.
Kon_2658
Vučković IM, Vujisić LV, Todosijević M, Stesevic D, Milosavljević SM, Trifunović SS. Volatile Constituents of Different Plant Parts and Populations of Malabaila aurea Boiss. from Montenegro. in Records of Natural Products. 2014;8(2):148-155.
Kon_2658 .
Vučković, Ivan M., Vujisić, Ljubodrag V., Todosijević, Marina, Stesevic, Danijela, Milosavljević, Slobodan M., Trifunović, Snežana S., "Volatile Constituents of Different Plant Parts and Populations of Malabaila aurea Boiss. from Montenegro" in Records of Natural Products, 8, no. 2 (2014):148-155,
Kon_2658 .
4
4

Medicinal plants in Northern Montenegro: Traditional knowledge, quality, and resources

Menković, N.; Šavikin, Katarina; Zdunić, Gordana; Milosavljević, Slobodan M.; Živković, Jelena

(2014)

TY  - CHAP
AU  - Menković, N.
AU  - Šavikin, Katarina
AU  - Zdunić, Gordana
AU  - Milosavljević, Slobodan M.
AU  - Živković, Jelena
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/288
AB  - The main objectives of this study were to collect information on the use of wild medicinal plants by local people living in the high mountain region of northern Montenegro and to conduct local botanical and ecological surveys. During terrain expeditions, 412 plant species (38 endemic) were identified, and the most abundant family was Rosaceae, followed by Cupressaceae and Lamiaceae. Plant use was documented by speaking with 75 people (mean age 57, 61∈% female, 39∈% male) who were born in and residents of northern Montenegro. Information on 116 plant species belonging to 40 families for the treatment of various human ailments was gathered. Botanical families, such as Asteraceae, Rosaceae, and Lamiaceae, were represented by the highest number of species reported by informants (14, 13, and 7 species, respectively). The most frequently reported medicinal uses were ones for treating gastrointestinal and respiratory diseases. Aerial parts (33.3∈%) were found to be highly utilized plant parts followed by roots (20.8∈%) and leaves (17.3∈%). Only two endemic species (Dianthus knapii and Pinus peuce) proved useful in folk tradition. Active ingredients of plant species officinal in the European Pharmacopoeia 6.0 (Ph. Eur. 6.0) were studied, and we assessed possibilities for commercial exploitation for local economic development. This work increases the ethnobotanical data from Montenegro, safeguards local folk knowledge, and provides information on new or scarcely reported properties of medicinal plants, whose traditional use requires experimental validation. © 2014 Springer Science+Business Media New York. All rights reserved.
T2  - Ethnobotany and Biocultural Diversities in the Balkans: Perspectives on Sustainable Rural Developmen
T1  - Medicinal plants in Northern Montenegro: Traditional knowledge, quality, and resources
SP  - 197
EP  - 228
DO  - 10.1007/978-1-4939-1492-0_11
UR  - Kon_1237
ER  - 
@inbook{
author = "Menković, N. and Šavikin, Katarina and Zdunić, Gordana and Milosavljević, Slobodan M. and Živković, Jelena",
year = "2014",
abstract = "The main objectives of this study were to collect information on the use of wild medicinal plants by local people living in the high mountain region of northern Montenegro and to conduct local botanical and ecological surveys. During terrain expeditions, 412 plant species (38 endemic) were identified, and the most abundant family was Rosaceae, followed by Cupressaceae and Lamiaceae. Plant use was documented by speaking with 75 people (mean age 57, 61∈% female, 39∈% male) who were born in and residents of northern Montenegro. Information on 116 plant species belonging to 40 families for the treatment of various human ailments was gathered. Botanical families, such as Asteraceae, Rosaceae, and Lamiaceae, were represented by the highest number of species reported by informants (14, 13, and 7 species, respectively). The most frequently reported medicinal uses were ones for treating gastrointestinal and respiratory diseases. Aerial parts (33.3∈%) were found to be highly utilized plant parts followed by roots (20.8∈%) and leaves (17.3∈%). Only two endemic species (Dianthus knapii and Pinus peuce) proved useful in folk tradition. Active ingredients of plant species officinal in the European Pharmacopoeia 6.0 (Ph. Eur. 6.0) were studied, and we assessed possibilities for commercial exploitation for local economic development. This work increases the ethnobotanical data from Montenegro, safeguards local folk knowledge, and provides information on new or scarcely reported properties of medicinal plants, whose traditional use requires experimental validation. © 2014 Springer Science+Business Media New York. All rights reserved.",
journal = "Ethnobotany and Biocultural Diversities in the Balkans: Perspectives on Sustainable Rural Developmen",
booktitle = "Medicinal plants in Northern Montenegro: Traditional knowledge, quality, and resources",
pages = "197-228",
doi = "10.1007/978-1-4939-1492-0_11",
url = "Kon_1237"
}
Menković, N., Šavikin, K., Zdunić, G., Milosavljević, S. M.,& Živković, J.. (2014). Medicinal plants in Northern Montenegro: Traditional knowledge, quality, and resources. in Ethnobotany and Biocultural Diversities in the Balkans: Perspectives on Sustainable Rural Developmen, 197-228.
https://doi.org/10.1007/978-1-4939-1492-0_11
Kon_1237
Menković N, Šavikin K, Zdunić G, Milosavljević SM, Živković J. Medicinal plants in Northern Montenegro: Traditional knowledge, quality, and resources. in Ethnobotany and Biocultural Diversities in the Balkans: Perspectives on Sustainable Rural Developmen. 2014;:197-228.
doi:10.1007/978-1-4939-1492-0_11
Kon_1237 .
Menković, N., Šavikin, Katarina, Zdunić, Gordana, Milosavljević, Slobodan M., Živković, Jelena, "Medicinal plants in Northern Montenegro: Traditional knowledge, quality, and resources" in Ethnobotany and Biocultural Diversities in the Balkans: Perspectives on Sustainable Rural Developmen (2014):197-228,
https://doi.org/10.1007/978-1-4939-1492-0_11 .,
Kon_1237 .
6
6

Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells

Novaković, Miroslav M.; Pešić, Milica; Trifunović, Snežana S.; Vučković, Ivan M.; Todorović, Nina; Podolski-Renić, Ana; Dinić, Jelena; Stojković, Sonja; Tešević, Vele; Vajs, Vlatka; Milosavljević, Slobodan M.

(Pergamon-Elsevier Science Ltd, Oxford, 2014)

TY  - JOUR
AU  - Novaković, Miroslav M.
AU  - Pešić, Milica
AU  - Trifunović, Snežana S.
AU  - Vučković, Ivan M.
AU  - Todorović, Nina
AU  - Podolski-Renić, Ana
AU  - Dinić, Jelena
AU  - Stojković, Sonja
AU  - Tešević, Vele
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1492
AB  - An extended study of minor diarylheptanoids from the bark of black alder has resulted in the isolation of twenty diarylheptanoids, ten of which have not previously been reported (14-18, 20-24). The structures and configurations of all compounds were elucidated by NMR, HRESIMS, UV, IR, and CD. The anti-cancer potency of twenty diarylheptanoids and four previously isolated compounds (7, 10, 12, 13) was investigated in human non-small cell lung carcinoma cell lines (sensitive and multi-drug resistant variants) as well as in normal human keratinocytes. Diarylheptanoids with a p-coumaroyl group, 14 and 18, platyphylloside (1), platyphyllonol-5-O-beta-D-xylopyranoside (2), alnuside B (4) and hirsutenone (9) exhibited strong anti-cancer activity, considerably higher than diarylheptanoid curcumin, which served as a positive control. Compounds 4, 9, 14, and 18 displayed significant selectivity towards the cancer cells. Structure/activity analysis of twenty-four closely related diarylheptanoids revealed a high dependence of cytotoxic action on the presence of a carbonyl group at C-3. Substitution of a heptane chain on C-5 and a number of hydroxyl groups in the aromatic rings also emerged as a significant structural feature that influenced their cytotoxic potential. (C) 2013 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells
VL  - 97
SP  - 46
EP  - 54
DO  - 10.1016/j.phytochem.2013.11.001
UR  - Kon_2612
ER  - 
@article{
author = "Novaković, Miroslav M. and Pešić, Milica and Trifunović, Snežana S. and Vučković, Ivan M. and Todorović, Nina and Podolski-Renić, Ana and Dinić, Jelena and Stojković, Sonja and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2014",
abstract = "An extended study of minor diarylheptanoids from the bark of black alder has resulted in the isolation of twenty diarylheptanoids, ten of which have not previously been reported (14-18, 20-24). The structures and configurations of all compounds were elucidated by NMR, HRESIMS, UV, IR, and CD. The anti-cancer potency of twenty diarylheptanoids and four previously isolated compounds (7, 10, 12, 13) was investigated in human non-small cell lung carcinoma cell lines (sensitive and multi-drug resistant variants) as well as in normal human keratinocytes. Diarylheptanoids with a p-coumaroyl group, 14 and 18, platyphylloside (1), platyphyllonol-5-O-beta-D-xylopyranoside (2), alnuside B (4) and hirsutenone (9) exhibited strong anti-cancer activity, considerably higher than diarylheptanoid curcumin, which served as a positive control. Compounds 4, 9, 14, and 18 displayed significant selectivity towards the cancer cells. Structure/activity analysis of twenty-four closely related diarylheptanoids revealed a high dependence of cytotoxic action on the presence of a carbonyl group at C-3. Substitution of a heptane chain on C-5 and a number of hydroxyl groups in the aromatic rings also emerged as a significant structural feature that influenced their cytotoxic potential. (C) 2013 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells",
volume = "97",
pages = "46-54",
doi = "10.1016/j.phytochem.2013.11.001",
url = "Kon_2612"
}
Novaković, M. M., Pešić, M., Trifunović, S. S., Vučković, I. M., Todorović, N., Podolski-Renić, A., Dinić, J., Stojković, S., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2014). Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 97, 46-54.
https://doi.org/10.1016/j.phytochem.2013.11.001
Kon_2612
Novaković MM, Pešić M, Trifunović SS, Vučković IM, Todorović N, Podolski-Renić A, Dinić J, Stojković S, Tešević V, Vajs V, Milosavljević SM. Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells. in Phytochemistry. 2014;97:46-54.
doi:10.1016/j.phytochem.2013.11.001
Kon_2612 .
Novaković, Miroslav M., Pešić, Milica, Trifunović, Snežana S., Vučković, Ivan M., Todorović, Nina, Podolski-Renić, Ana, Dinić, Jelena, Stojković, Sonja, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Diarylheptanoids from the bark of black alder inhibit the growth of sensitive and multi-drug resistant non-small cell lung carcinoma cells" in Phytochemistry, 97 (2014):46-54,
https://doi.org/10.1016/j.phytochem.2013.11.001 .,
Kon_2612 .
26
29
30

Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines

Aljančić, Ivana; Vučković, Ivan M.; Jadranin, Milka; Pešić, Milica; Đorđević, Iris; Podolski-Renić, Ana; Stojković, Sonja; Menkovic, Nebojsa; Vajs, Vlatka; Milosavljević, Slobodan M.

(Pergamon-Elsevier Science Ltd, Oxford, 2014)

TY  - JOUR
AU  - Aljančić, Ivana
AU  - Vučković, Ivan M.
AU  - Jadranin, Milka
AU  - Pešić, Milica
AU  - Đorđević, Iris
AU  - Podolski-Renić, Ana
AU  - Stojković, Sonja
AU  - Menkovic, Nebojsa
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1500
AB  - Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. (C) 2013 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines
VL  - 98
SP  - 190
EP  - 196
DO  - 10.1016/j.phytochem.2013.11.025
UR  - Kon_2620
ER  - 
@article{
author = "Aljančić, Ivana and Vučković, Ivan M. and Jadranin, Milka and Pešić, Milica and Đorđević, Iris and Podolski-Renić, Ana and Stojković, Sonja and Menkovic, Nebojsa and Vajs, Vlatka and Milosavljević, Slobodan M.",
year = "2014",
abstract = "Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. (C) 2013 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines",
volume = "98",
pages = "190-196",
doi = "10.1016/j.phytochem.2013.11.025",
url = "Kon_2620"
}
Aljančić, I., Vučković, I. M., Jadranin, M., Pešić, M., Đorđević, I., Podolski-Renić, A., Stojković, S., Menkovic, N., Vajs, V.,& Milosavljević, S. M.. (2014). Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 98, 190-196.
https://doi.org/10.1016/j.phytochem.2013.11.025
Kon_2620
Aljančić I, Vučković IM, Jadranin M, Pešić M, Đorđević I, Podolski-Renić A, Stojković S, Menkovic N, Vajs V, Milosavljević SM. Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry. 2014;98:190-196.
doi:10.1016/j.phytochem.2013.11.025
Kon_2620 .
Aljančić, Ivana, Vučković, Ivan M., Jadranin, Milka, Pešić, Milica, Đorđević, Iris, Podolski-Renić, Ana, Stojković, Sonja, Menkovic, Nebojsa, Vajs, Vlatka, Milosavljević, Slobodan M., "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines" in Phytochemistry, 98 (2014):190-196,
https://doi.org/10.1016/j.phytochem.2013.11.025 .,
Kon_2620 .
24
15
14

New Pseudoguaiane Derivatives from Inula aschersoniana Janka var. aschersoniana

Trendafilova, Antoaneta; Todorova, Milka; Genova, Viktoriya; Shestakova, Pavletta; Dimitrov, Dimitar; Jadranin, Milka; Milosavljević, Slobodan M.

(Natural Products Inc, Westerville, 2014)

TY  - JOUR
AU  - Trendafilova, Antoaneta
AU  - Todorova, Milka
AU  - Genova, Viktoriya
AU  - Shestakova, Pavletta
AU  - Dimitrov, Dimitar
AU  - Jadranin, Milka
AU  - Milosavljević, Slobodan M.
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1829
AB  - The aerial parts of Inula aschersoniana Janka var. aschersoniana afforded parthenolide, diepoxycostunolide, inusoniolide, chrysosplenol C and four new pseudoguaiane-type sesquiterpenoids. Their structures were determined using spectral methods and relative stereochemistry by NOESY correlations.
PB  - Natural Products Inc, Westerville
T2  - Natural Product Communications
T1  - New Pseudoguaiane Derivatives from Inula aschersoniana Janka var. aschersoniana
VL  - 9
IS  - 8
SP  - 1123
EP  - 1124
UR  - Kon_2712
ER  - 
@article{
author = "Trendafilova, Antoaneta and Todorova, Milka and Genova, Viktoriya and Shestakova, Pavletta and Dimitrov, Dimitar and Jadranin, Milka and Milosavljević, Slobodan M.",
year = "2014",
abstract = "The aerial parts of Inula aschersoniana Janka var. aschersoniana afforded parthenolide, diepoxycostunolide, inusoniolide, chrysosplenol C and four new pseudoguaiane-type sesquiterpenoids. Their structures were determined using spectral methods and relative stereochemistry by NOESY correlations.",
publisher = "Natural Products Inc, Westerville",
journal = "Natural Product Communications",
title = "New Pseudoguaiane Derivatives from Inula aschersoniana Janka var. aschersoniana",
volume = "9",
number = "8",
pages = "1123-1124",
url = "Kon_2712"
}
Trendafilova, A., Todorova, M., Genova, V., Shestakova, P., Dimitrov, D., Jadranin, M.,& Milosavljević, S. M.. (2014). New Pseudoguaiane Derivatives from Inula aschersoniana Janka var. aschersoniana. in Natural Product Communications
Natural Products Inc, Westerville., 9(8), 1123-1124.
Kon_2712
Trendafilova A, Todorova M, Genova V, Shestakova P, Dimitrov D, Jadranin M, Milosavljević SM. New Pseudoguaiane Derivatives from Inula aschersoniana Janka var. aschersoniana. in Natural Product Communications. 2014;9(8):1123-1124.
Kon_2712 .
Trendafilova, Antoaneta, Todorova, Milka, Genova, Viktoriya, Shestakova, Pavletta, Dimitrov, Dimitar, Jadranin, Milka, Milosavljević, Slobodan M., "New Pseudoguaiane Derivatives from Inula aschersoniana Janka var. aschersoniana" in Natural Product Communications, 9, no. 8 (2014):1123-1124,
Kon_2712 .
2
2

Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro

Cvetković, Mirjana; Đorđević, Iris; Jadranin, Milka; Vajs, Vlatka; Vučković, Ivan M.; Menkovic, Nebojsa; Milosavljević, Slobodan M.; Tešević, Vele

(Wiley-V C H Verlag Gmbh, Weinheim, 2014)

TY  - JOUR
AU  - Cvetković, Mirjana
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Vajs, Vlatka
AU  - Vučković, Ivan M.
AU  - Menkovic, Nebojsa
AU  - Milosavljević, Slobodan M.
AU  - Tešević, Vele
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1855
AB  - Analysis of composition of sesquiterpene lactone fraction of leaf cuticular neutral lipids of Amphoricarpos complex from two different localities in north Montenegro, i.e., canyon of river Tara (A. autariatus ssp. autariatus) and mountain Zeletin (A. autariatus ssp. bertisceus) afforded sesquiterpene lactones with guaianolide skeletons (17 compounds), so called amphoricarpolides, typical for this genus. Nine of them, 9-17, were new compounds, and their structures were elucidated by detailed analyses of IR, NMR, and MS data.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry and Biodiversity
T1  - Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro
VL  - 11
IS  - 9
SP  - 1428
EP  - 1437
DO  - 10.1002/cbdv.201400101
UR  - Kon_2738
ER  - 
@article{
author = "Cvetković, Mirjana and Đorđević, Iris and Jadranin, Milka and Vajs, Vlatka and Vučković, Ivan M. and Menkovic, Nebojsa and Milosavljević, Slobodan M. and Tešević, Vele",
year = "2014",
abstract = "Analysis of composition of sesquiterpene lactone fraction of leaf cuticular neutral lipids of Amphoricarpos complex from two different localities in north Montenegro, i.e., canyon of river Tara (A. autariatus ssp. autariatus) and mountain Zeletin (A. autariatus ssp. bertisceus) afforded sesquiterpene lactones with guaianolide skeletons (17 compounds), so called amphoricarpolides, typical for this genus. Nine of them, 9-17, were new compounds, and their structures were elucidated by detailed analyses of IR, NMR, and MS data.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry and Biodiversity",
title = "Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro",
volume = "11",
number = "9",
pages = "1428-1437",
doi = "10.1002/cbdv.201400101",
url = "Kon_2738"
}
Cvetković, M., Đorđević, I., Jadranin, M., Vajs, V., Vučković, I. M., Menkovic, N., Milosavljević, S. M.,& Tešević, V.. (2014). Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro. in Chemistry and Biodiversity
Wiley-V C H Verlag Gmbh, Weinheim., 11(9), 1428-1437.
https://doi.org/10.1002/cbdv.201400101
Kon_2738
Cvetković M, Đorđević I, Jadranin M, Vajs V, Vučković IM, Menkovic N, Milosavljević SM, Tešević V. Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro. in Chemistry and Biodiversity. 2014;11(9):1428-1437.
doi:10.1002/cbdv.201400101
Kon_2738 .
Cvetković, Mirjana, Đorđević, Iris, Jadranin, Milka, Vajs, Vlatka, Vučković, Ivan M., Menkovic, Nebojsa, Milosavljević, Slobodan M., Tešević, Vele, "Further Amphoricarpolides from the Surface Extracts of Amphoricarpos Complex from Montenegro" in Chemistry and Biodiversity, 11, no. 9 (2014):1428-1437,
https://doi.org/10.1002/cbdv.201400101 .,
Kon_2738 .
5
6
6

Secondary metabolites of three endemic Centaurea L. species

Tešević, Vele; Aljančić, Ivana; Milosavljević, Slobodan M.; Vajs, Vlatka; Đorđević, Iris; Jadranin, Milka; Menkovic, Nebojsa; Matevski, Vlado

(Serbian Chemical Soc, Belgrade, 2014)

TY  - JOUR
AU  - Tešević, Vele
AU  - Aljančić, Ivana
AU  - Milosavljević, Slobodan M.
AU  - Vajs, Vlatka
AU  - Đorđević, Iris
AU  - Jadranin, Milka
AU  - Menkovic, Nebojsa
AU  - Matevski, Vlado
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1890
AB  - The aerial parts of three endemic Centaurea L. species, namely C. tomorosii Micevski, C. soskae Hayek and C. galicicae Micevski, afforded the sesquiterpene lactone cnicin (1) and seven flavonoids: apigenin (2), isokaempferide (3), hispidulin (4), eupatorin (5), cirsimaritin (6), santoflavone (7) and salvigenin (8). The structures of the isolated compounds were determined by UV, H-1-NMR and C-13-NMR spectroscopy and HR-ESI-MS spectrometry. H-1-NMR spectroscopy was used as a method for the quantitative analysis of cnicin.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Secondary metabolites of three endemic Centaurea L. species
VL  - 79
IS  - 11
SP  - 1355
EP  - 1362
DO  - 10.2298/JSC140318048T
UR  - Kon_2773
ER  - 
@article{
author = "Tešević, Vele and Aljančić, Ivana and Milosavljević, Slobodan M. and Vajs, Vlatka and Đorđević, Iris and Jadranin, Milka and Menkovic, Nebojsa and Matevski, Vlado",
year = "2014",
abstract = "The aerial parts of three endemic Centaurea L. species, namely C. tomorosii Micevski, C. soskae Hayek and C. galicicae Micevski, afforded the sesquiterpene lactone cnicin (1) and seven flavonoids: apigenin (2), isokaempferide (3), hispidulin (4), eupatorin (5), cirsimaritin (6), santoflavone (7) and salvigenin (8). The structures of the isolated compounds were determined by UV, H-1-NMR and C-13-NMR spectroscopy and HR-ESI-MS spectrometry. H-1-NMR spectroscopy was used as a method for the quantitative analysis of cnicin.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Secondary metabolites of three endemic Centaurea L. species",
volume = "79",
number = "11",
pages = "1355-1362",
doi = "10.2298/JSC140318048T",
url = "Kon_2773"
}
Tešević, V., Aljančić, I., Milosavljević, S. M., Vajs, V., Đorđević, I., Jadranin, M., Menkovic, N.,& Matevski, V.. (2014). Secondary metabolites of three endemic Centaurea L. species. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 79(11), 1355-1362.
https://doi.org/10.2298/JSC140318048T
Kon_2773
Tešević V, Aljančić I, Milosavljević SM, Vajs V, Đorđević I, Jadranin M, Menkovic N, Matevski V. Secondary metabolites of three endemic Centaurea L. species. in Journal of the Serbian Chemical Society. 2014;79(11):1355-1362.
doi:10.2298/JSC140318048T
Kon_2773 .
Tešević, Vele, Aljančić, Ivana, Milosavljević, Slobodan M., Vajs, Vlatka, Đorđević, Iris, Jadranin, Milka, Menkovic, Nebojsa, Matevski, Vlado, "Secondary metabolites of three endemic Centaurea L. species" in Journal of the Serbian Chemical Society, 79, no. 11 (2014):1355-1362,
https://doi.org/10.2298/JSC140318048T .,
Kon_2773 .
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9

The contents of heavy metals in Serbian old plum brandies

Bonic, Mirjana; Tešević, Vele; Nikićević, Ninoslav; Cvejic, Jelena; Milosavljević, Slobodan M.; Vajs, Vlatka; Mandić, Boris; Urosevic, Ivan; Veličković, Milovan; Jovanic, Sasa

(Serbian Chemical Soc, Belgrade, 2013)

TY  - JOUR
AU  - Bonic, Mirjana
AU  - Tešević, Vele
AU  - Nikićević, Ninoslav
AU  - Cvejic, Jelena
AU  - Milosavljević, Slobodan M.
AU  - Vajs, Vlatka
AU  - Mandić, Boris
AU  - Urosevic, Ivan
AU  - Veličković, Milovan
AU  - Jovanic, Sasa
PY  - 2013
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1383
AB  - Seven elements, namely, arsenic, lead, cadmium, copper, zinc, iron and manganese were determined in 31 samples of Serbian plum brandies by application of atomic spectrometry techniques. Flame atomic absorption spectrometry was used for the quantification of copper, iron, zinc, manganese, lead and cadmium, and hydride generation atomic spectrometry absorption for arsenic quantification. The measured concentrations of the heavy metals and arsenic were assessed according to Serbian regulations, official regulations of some other countries and in respect to the content of microelements in other similar distilled alcoholic beverages. The amounts of microelements in the maximal recommended daily and weekly intake of plum brandy were determined. The influence of production (home made or industrial), type of wooden barrel (oak or mulberry), and duration of ageing process on the content of Zn, Cu, Fe and Mn in plum brandies, as well as the coefficient of correlation between the Cu content and pH value were also studied.
AB  - Sedam elemenata: arsen, olovo, kadmijum, bakar, cink, gvožđe i mangan su određivani u 31 uzorku srpskih rakija šljivovica primenom tehnike atomske apsorpcione spektrometrije. Plamena atomska apsorpciona spektrometrija je korišćena za kvantifikaciju bakra, gvožđa, cinka, olova, mangana i kadmijuma, a hidridna tehnika atomske apsorpcione spektrometrije za kvantifikaciju arsena. Izmerena koncentracija teških metala i arsena je u skladu sa propisima Republike Srbije, zvaničnim propisima nekih drugih zemalja i drugim sličnim jakim alkoholnim pićima. Količina mikroelemenata u maksimalnom dnevnom i nedeljnom unosu rakije šljivovice je određena. Uticaj proizvodnje (domaća i industijska), vrste drvenih buradi (hrast i dud), trajanje procesa sazrevanja na sadržaj cinka, bakra, gvožđa i mangana u šljivovicama, kao i koeficijent korelacije između sadržaja bakra i pH je takođe ispitivan.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - The contents of heavy metals in Serbian old plum brandies
T1  - Sadržaj teških metala u starim srpskim rakijama šljivovicama
VL  - 78
IS  - 7
SP  - 933
EP  - 945
DO  - 10.2298/JSC121106016B
UR  - Kon_2503
ER  - 
@article{
author = "Bonic, Mirjana and Tešević, Vele and Nikićević, Ninoslav and Cvejic, Jelena and Milosavljević, Slobodan M. and Vajs, Vlatka and Mandić, Boris and Urosevic, Ivan and Veličković, Milovan and Jovanic, Sasa",
year = "2013",
abstract = "Seven elements, namely, arsenic, lead, cadmium, copper, zinc, iron and manganese were determined in 31 samples of Serbian plum brandies by application of atomic spectrometry techniques. Flame atomic absorption spectrometry was used for the quantification of copper, iron, zinc, manganese, lead and cadmium, and hydride generation atomic spectrometry absorption for arsenic quantification. The measured concentrations of the heavy metals and arsenic were assessed according to Serbian regulations, official regulations of some other countries and in respect to the content of microelements in other similar distilled alcoholic beverages. The amounts of microelements in the maximal recommended daily and weekly intake of plum brandy were determined. The influence of production (home made or industrial), type of wooden barrel (oak or mulberry), and duration of ageing process on the content of Zn, Cu, Fe and Mn in plum brandies, as well as the coefficient of correlation between the Cu content and pH value were also studied., Sedam elemenata: arsen, olovo, kadmijum, bakar, cink, gvožđe i mangan su određivani u 31 uzorku srpskih rakija šljivovica primenom tehnike atomske apsorpcione spektrometrije. Plamena atomska apsorpciona spektrometrija je korišćena za kvantifikaciju bakra, gvožđa, cinka, olova, mangana i kadmijuma, a hidridna tehnika atomske apsorpcione spektrometrije za kvantifikaciju arsena. Izmerena koncentracija teških metala i arsena je u skladu sa propisima Republike Srbije, zvaničnim propisima nekih drugih zemalja i drugim sličnim jakim alkoholnim pićima. Količina mikroelemenata u maksimalnom dnevnom i nedeljnom unosu rakije šljivovice je određena. Uticaj proizvodnje (domaća i industijska), vrste drvenih buradi (hrast i dud), trajanje procesa sazrevanja na sadržaj cinka, bakra, gvožđa i mangana u šljivovicama, kao i koeficijent korelacije između sadržaja bakra i pH je takođe ispitivan.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "The contents of heavy metals in Serbian old plum brandies, Sadržaj teških metala u starim srpskim rakijama šljivovicama",
volume = "78",
number = "7",
pages = "933-945",
doi = "10.2298/JSC121106016B",
url = "Kon_2503"
}
Bonic, M., Tešević, V., Nikićević, N., Cvejic, J., Milosavljević, S. M., Vajs, V., Mandić, B., Urosevic, I., Veličković, M.,& Jovanic, S.. (2013). The contents of heavy metals in Serbian old plum brandies. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 78(7), 933-945.
https://doi.org/10.2298/JSC121106016B
Kon_2503
Bonic M, Tešević V, Nikićević N, Cvejic J, Milosavljević SM, Vajs V, Mandić B, Urosevic I, Veličković M, Jovanic S. The contents of heavy metals in Serbian old plum brandies. in Journal of the Serbian Chemical Society. 2013;78(7):933-945.
doi:10.2298/JSC121106016B
Kon_2503 .
Bonic, Mirjana, Tešević, Vele, Nikićević, Ninoslav, Cvejic, Jelena, Milosavljević, Slobodan M., Vajs, Vlatka, Mandić, Boris, Urosevic, Ivan, Veličković, Milovan, Jovanic, Sasa, "The contents of heavy metals in Serbian old plum brandies" in Journal of the Serbian Chemical Society, 78, no. 7 (2013):933-945,
https://doi.org/10.2298/JSC121106016B .,
Kon_2503 .
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