TY  - JOUR
AU  - Baroud, Afya A.
AU  - Mihajlović-Lalić, Ljiljana
AU  - Gligorijević, Nevenka
AU  - Aranđelović, Sandra
AU  - Stanković, Dalibor
AU  - Radulović, Siniša
AU  - Van Hecke, Kristof
AU  - Savić, Aleksandar
AU  - Grgurić-Šipka, Sanja
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2423
AB  - Complexes 1-4, [Ru(L)(bpy)(2)]PF6, where bpy=2,2-bipyridine; HL=3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) and 6-bromopyridine-2-carboxylic acid (HL4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 +/- 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200M. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction. [GRAPHICS]
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Coordination Chemistry
T1  - Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation
VL  - 70
IS  - 5
SP  - 831
EP  - 847
DO  - 10.1080/00958972.2017.1282611
ER  - 

@article{
author = "Baroud, Afya A. and Mihajlović-Lalić, Ljiljana and Gligorijević, Nevenka and Aranđelović, Sandra and Stanković, Dalibor and Radulović, Siniša and Van Hecke, Kristof and Savić, Aleksandar and Grgurić-Šipka, Sanja",
year = "2017",
abstract = "Complexes 1-4, [Ru(L)(bpy)(2)]PF6, where bpy=2,2-bipyridine; HL=3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) and 6-bromopyridine-2-carboxylic acid (HL4), were synthesized and characterized. The electrochemical character of the complexes was investigated by cyclic voltammetry revealing two reversible reduction waves in the negative range of potentials, most likely due to a reduction of the bipyridine moiety. Cytotoxicity studies by MTT assay for 72h of drug action revealed that 2-4 exhibited moderate activity in cervical human tumor cells (HeLa). Complex 2 exhibited low activity in colon cancer LS-174 cells (180 +/- 10), while all complexes were devoid of activity in lung cancer A549 and non-tumor MRC-5 cells, up to 200M. Combinational studies of the most active complex 2, with pharmacological modulators of cell redox status, L-buthionine-sulfoximine (L-BSO) or N-acetyl-L-cysteine (NAC), showed that when L-BSO potentiated, 2 induced a sub-G1 peak of the cell cycle in the HeLa cell line. UV-vis and cyclic voltammetry were performed in order to investigate the binding mode of 2 to DNA and suggested intercalation for the complex-DNA interaction. [GRAPHICS]",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Coordination Chemistry",
title = "Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation",
volume = "70",
number = "5",
pages = "831-847",
doi = "10.1080/00958972.2017.1282611"
}

Baroud, A. A., Mihajlović-Lalić, L., Gligorijević, N., Aranđelović, S., Stanković, D., Radulović, S., Van Hecke, K., Savić, A.,& Grgurić-Šipka, S.. (2017). Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation. in Journal of Coordination Chemistry
Taylor & Francis Ltd, Abingdon., 70(5), 831-847.
https://doi.org/10.1080/00958972.2017.1282611

Baroud AA, Mihajlović-Lalić L, Gligorijević N, Aranđelović S, Stanković D, Radulović S, Van Hecke K, Savić A, Grgurić-Šipka S. Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation. in Journal of Coordination Chemistry. 2017;70(5):831-847.
doi:10.1080/00958972.2017.1282611 .

Baroud, Afya A., Mihajlović-Lalić, Ljiljana, Gligorijević, Nevenka, Aranđelović, Sandra, Stanković, Dalibor, Radulović, Siniša, Van Hecke, Kristof, Savić, Aleksandar, Grgurić-Šipka, Sanja, "Ruthenium(II) bipyridine complexes: from synthesis and crystal structures to electrochemical and cytotoxicity investigation" in Journal of Coordination Chemistry, 70, no. 5 (2017):831-847,
https://doi.org/10.1080/00958972.2017.1282611 . .

TY  - JOUR
AU  - Baroud, Afya A.
AU  - Mihajlović-Lalić, Ljiljana
AU  - Stanković, Dalibor
AU  - Kajzerberger, Marijana
AU  - Van Hecke, Kristof
AU  - Grgurić-Šipka, Sanja
AU  - Savić, Aleksandar
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2457
AB  - A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were  gt 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity
VL  - 82
IS  - 3
SP  - 267
EP  - 275
DO  - 10.2298/JSC170109025B
ER  - 

@article{
author = "Baroud, Afya A. and Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Kajzerberger, Marijana and Van Hecke, Kristof and Grgurić-Šipka, Sanja and Savić, Aleksandar",
year = "2017",
abstract = "A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were  gt 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity",
volume = "82",
number = "3",
pages = "267-275",
doi = "10.2298/JSC170109025B"
}

Baroud, A. A., Mihajlović-Lalić, L., Stanković, D., Kajzerberger, M., Van Hecke, K., Grgurić-Šipka, S.,& Savić, A.. (2017). New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 82(3), 267-275.
https://doi.org/10.2298/JSC170109025B

Baroud AA, Mihajlović-Lalić L, Stanković D, Kajzerberger M, Van Hecke K, Grgurić-Šipka S, Savić A. New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity. in Journal of the Serbian Chemical Society. 2017;82(3):267-275.
doi:10.2298/JSC170109025B .

Baroud, Afya A., Mihajlović-Lalić, Ljiljana, Stanković, Dalibor, Kajzerberger, Marijana, Van Hecke, Kristof, Grgurić-Šipka, Sanja, Savić, Aleksandar, "New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity" in Journal of the Serbian Chemical Society, 82, no. 3 (2017):267-275,
https://doi.org/10.2298/JSC170109025B . .

TY  - THES
AU  - Baroud, Afya A.
PY  - 2017
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=5612
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:17155/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49838351
UR  - http://nardus.mpn.gov.rs/123456789/9241
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2755
AB  - Bis(bipiridin)rutenijum(II) kompleksi (1-5) opšte formule [Ru(L)(bpy)2]PF6, gde je bpy = 2,2′-bipiridin; HL = 3-metilpiridin-2-karboksilna kiselina (HL1), 6-metilpiridin-2-karboksilna kiselina (HL2), 5-bromopiridin-2-karboksilna kiselina (HL3) 6-brompiridin-2-karboksilna kiselina (HL4) i piridin-2,4-dikarboksilna kiselina (HL5) su sintetisani i potpuno okarakterisani. Za jedinjenja 3, 4 and 5 urađena je difrakcionom analizom X-zraka na monokristalu...
AB  - Bis(bipyridine)ruthenium(II) complexes (1-5) of general formula [Ru(L)(bpy)2]PF6, where bpy = 2,2′-bipyridine; HL = 3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) 6-bromopyridine-2-carboxylic acid (HL4) and pyridine-2,4-dicarboxylic acid (HL5) were synthesized and fully characterized. For compounds 3, 4 and 5 single-crystal X-ray diffraction analyses were also performed...
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Synthesis, characterization and cytotoxicity of bis(bipyridine) ruthenium(II) complexes with picolinic acid derivatives
UR  - https://hdl.handle.net/21.15107/rcub_nardus_9241
ER  - 

@phdthesis{
author = "Baroud, Afya A.",
year = "2017",
abstract = "Bis(bipiridin)rutenijum(II) kompleksi (1-5) opšte formule [Ru(L)(bpy)2]PF6, gde je bpy = 2,2′-bipiridin; HL = 3-metilpiridin-2-karboksilna kiselina (HL1), 6-metilpiridin-2-karboksilna kiselina (HL2), 5-bromopiridin-2-karboksilna kiselina (HL3) 6-brompiridin-2-karboksilna kiselina (HL4) i piridin-2,4-dikarboksilna kiselina (HL5) su sintetisani i potpuno okarakterisani. Za jedinjenja 3, 4 and 5 urađena je difrakcionom analizom X-zraka na monokristalu..., Bis(bipyridine)ruthenium(II) complexes (1-5) of general formula [Ru(L)(bpy)2]PF6, where bpy = 2,2′-bipyridine; HL = 3-methylpyridine-2-carboxylic acid (HL1), 6-methylpyridine-2-carboxylic acid (HL2), 5-bromopyridine-2-carboxylic acid (HL3) 6-bromopyridine-2-carboxylic acid (HL4) and pyridine-2,4-dicarboxylic acid (HL5) were synthesized and fully characterized. For compounds 3, 4 and 5 single-crystal X-ray diffraction analyses were also performed...",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Synthesis, characterization and cytotoxicity of bis(bipyridine) ruthenium(II) complexes with picolinic acid derivatives",
url = "https://hdl.handle.net/21.15107/rcub_nardus_9241"
}

Baroud, A. A.. (2017). Synthesis, characterization and cytotoxicity of bis(bipyridine) ruthenium(II) complexes with picolinic acid derivatives. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_9241

Baroud AA. Synthesis, characterization and cytotoxicity of bis(bipyridine) ruthenium(II) complexes with picolinic acid derivatives. in Универзитет у Београду. 2017;.
https://hdl.handle.net/21.15107/rcub_nardus_9241 .

Baroud, Afya A., "Synthesis, characterization and cytotoxicity of bis(bipyridine) ruthenium(II) complexes with picolinic acid derivatives" in Универзитет у Београду (2017),
https://hdl.handle.net/21.15107/rcub_nardus_9241 .

TY  - JOUR
AU  - Savić, Aleksandar
AU  - Baroud, Afya A.
AU  - Grgurić-Šipka, Sanja
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1778
AB  - The new bipyridyl complex of ruthenium(II) with O, O'-diethyl-(S, S)-ethylenediamine- N, N'-di- 2(3-cyclohexyl) propanoate was synthesized. The reaction of cis-[RuCl2(bpy)(2)] and its ligand was performed in water/ethanol solution, in the presence of lithium hydroxide, under reflux. After the addition of ammonium hexafluorophosphate, the complex was precipitated. The complex, cis-[Ru(bpy)(2)L](PF6)(2), was characterized by H-1 and C-13 NMR, UV-Vis, IR spectroscopy, ESI-MS spectrometry and elemental analysis. Results indicate an octahedral geometry of the complex, with N, N'-coordinated O, O'- diethyl-(S, S)ethylenediamine-N, N'-di- 2-(3-cyclohexyl) propanoate. Complexes of this type are particularly important in terms of potential cytotoxicity and application in photodynamic therapy. Using this therapy, many side effects can be reduced, which may allow the administration of higher drug dosages.
PB  - Soc Chemists Technologists Madeconia, Skopje
T2  - Macedonian Journal of Chemistry and Chemical Engineering
T1  - The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization
VL  - 33
IS  - 1
SP  - 59
EP  - 64
DO  - 10.20450/mjcce.2014.424
ER  - 

@article{
author = "Savić, Aleksandar and Baroud, Afya A. and Grgurić-Šipka, Sanja",
year = "2014",
abstract = "The new bipyridyl complex of ruthenium(II) with O, O'-diethyl-(S, S)-ethylenediamine- N, N'-di- 2(3-cyclohexyl) propanoate was synthesized. The reaction of cis-[RuCl2(bpy)(2)] and its ligand was performed in water/ethanol solution, in the presence of lithium hydroxide, under reflux. After the addition of ammonium hexafluorophosphate, the complex was precipitated. The complex, cis-[Ru(bpy)(2)L](PF6)(2), was characterized by H-1 and C-13 NMR, UV-Vis, IR spectroscopy, ESI-MS spectrometry and elemental analysis. Results indicate an octahedral geometry of the complex, with N, N'-coordinated O, O'- diethyl-(S, S)ethylenediamine-N, N'-di- 2-(3-cyclohexyl) propanoate. Complexes of this type are particularly important in terms of potential cytotoxicity and application in photodynamic therapy. Using this therapy, many side effects can be reduced, which may allow the administration of higher drug dosages.",
publisher = "Soc Chemists Technologists Madeconia, Skopje",
journal = "Macedonian Journal of Chemistry and Chemical Engineering",
title = "The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization",
volume = "33",
number = "1",
pages = "59-64",
doi = "10.20450/mjcce.2014.424"
}

Savić, A., Baroud, A. A.,& Grgurić-Šipka, S.. (2014). The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization. in Macedonian Journal of Chemistry and Chemical Engineering
Soc Chemists Technologists Madeconia, Skopje., 33(1), 59-64.
https://doi.org/10.20450/mjcce.2014.424

Savić A, Baroud AA, Grgurić-Šipka S. The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization. in Macedonian Journal of Chemistry and Chemical Engineering. 2014;33(1):59-64.
doi:10.20450/mjcce.2014.424 .

Savić, Aleksandar, Baroud, Afya A., Grgurić-Šipka, Sanja, "The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization" in Macedonian Journal of Chemistry and Chemical Engineering, 33, no. 1 (2014):59-64,
https://doi.org/10.20450/mjcce.2014.424 . .