TY  - JOUR
AU  - Kop, Tatjana
AU  - Popović-Đorđević, Jelena
AU  - Bjelaković, Mira S.
AU  - Milić, Dragana
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2565
AB  - Four macrocyclic bis(pyrrolidino)fullerene regioisomers with e-edge, e-face, trans-4 and cis-2 addition patterns were synthesized from the corresponding monoadduct by Prato's cycloaddition in a yield of 50%, and fully characterized by spectroscopic techniques. Bisadduct regioisomers were isolated easily in a pure form using dry-flash column chromatography. The relative ratio of the isolated regioisomers e-edge/e-face/trans-41cis-2 was 1.0:1.9:1.5:4.9. Morphology of self-assembled structures of the four bisadduct regioisomers in solution was characterized using scanning electron microscopy. (C) 2017 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Tetrahedron
T1  - Fullerene bisadduct regioisomers containing an asymmetric diamide tether
VL  - 73
IS  - 50
SP  - 7073
EP  - 7078
DO  - 10.1016/j.tet.2017.10.069
ER  - 

@article{
author = "Kop, Tatjana and Popović-Đorđević, Jelena and Bjelaković, Mira S. and Milić, Dragana",
year = "2017",
abstract = "Four macrocyclic bis(pyrrolidino)fullerene regioisomers with e-edge, e-face, trans-4 and cis-2 addition patterns were synthesized from the corresponding monoadduct by Prato's cycloaddition in a yield of 50%, and fully characterized by spectroscopic techniques. Bisadduct regioisomers were isolated easily in a pure form using dry-flash column chromatography. The relative ratio of the isolated regioisomers e-edge/e-face/trans-41cis-2 was 1.0:1.9:1.5:4.9. Morphology of self-assembled structures of the four bisadduct regioisomers in solution was characterized using scanning electron microscopy. (C) 2017 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron",
title = "Fullerene bisadduct regioisomers containing an asymmetric diamide tether",
volume = "73",
number = "50",
pages = "7073-7078",
doi = "10.1016/j.tet.2017.10.069"
}

Kop, T., Popović-Đorđević, J., Bjelaković, M. S.,& Milić, D.. (2017). Fullerene bisadduct regioisomers containing an asymmetric diamide tether. in Tetrahedron
Pergamon-Elsevier Science Ltd, Oxford., 73(50), 7073-7078.
https://doi.org/10.1016/j.tet.2017.10.069

Kop T, Popović-Đorđević J, Bjelaković MS, Milić D. Fullerene bisadduct regioisomers containing an asymmetric diamide tether. in Tetrahedron. 2017;73(50):7073-7078.
doi:10.1016/j.tet.2017.10.069 .

Kop, Tatjana, Popović-Đorđević, Jelena, Bjelaković, Mira S., Milić, Dragana, "Fullerene bisadduct regioisomers containing an asymmetric diamide tether" in Tetrahedron, 73, no. 50 (2017):7073-7078,
https://doi.org/10.1016/j.tet.2017.10.069 . .

TY  - JOUR
AU  - Smiljanić, Katarina
AU  - Savić, Kristina
AU  - Obradovic, Milan
AU  - Putniković, Biljana
AU  - Đorđević, Jelena
AU  - Isenović, Esma
PY  - 2013
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6448
AB  - Kardiovaskularne bolesti predstavljaju najveći uzrok smrtnosti ljudske populacije, a jedna od njihovih najučestalijih patoloških komponenti je i sama ateroskleroza. Proliferacija ili deoba glatkih mišićnih ćelija krvnih sudova (VSMC) ključni je događaj u nastanku raznih vaskularnih oboljenja, uključujući aterosklerozu i hipertenziju. U procesu diferencijacije i abnormalne deobe VSMC povezanih sa hipertenzijom i aterosklerozom uključen je i trombin. Stimulisanje VSMC trombinom dovodi do aktivacije ekstracelularnim signalima regulisanih kinaza 1 i 2 (ERK1/2), preko transaktivacije receptora za epidermalni faktor rasta (EGFR). U našim ranijim studijama potvrdili smo na osnovu inhibicije ERK1/2 od strane PD9805 inhibitora, učešće ERK1/2 u regulaciji proliferacije VSMC izazvanoj trombinom. Takođe, protein kinaza C delta (PKCδ), detektovana je u VSMC i pokazano je da je i njena aktivnost takođe regulisana trombinom. U okviru ovog preglednog članka biće prikazani literaturni podaci koji se odnose na ulogu PKCδ i ERK1/2, u posredovanju proliferativnog efekta trombina na VSMC.
AB  - Cardiovascular disease is the greatestest single
cause of mortality and its major underlying pathology
is atherosclerosis. The proliferation of vascular smooth
muscle cells (VSMC) is a key event in the pathogenesis
of various vascular diseases, including atherosclerosis
and hypertension. Thrombin is involved in the
differentiation and abnormal proliferation of VSMC
associated with atherosclerosis and hypertension.
Thrombin stimulation results in extracellular
signal-regulated kinase (ERK1/2) activation through
transactivation of the epidermal growth factor receptor
(EGFR). Based on our reacent studies in which
PD98059 used to inhibit ERK1/2, we have shown
previously that ERK1/2 was involved in the regulation
by thrombin of VSMC’s proliferation. In addition,
protein kinase C delta (PKCδ) have also been detected
in VSMC and shown to be regulated by thrombin.
In this review, we are presenting literature data
relating to role of PKCδ and ERK1/2 in mediating the
mitogenic action of thrombin in VSMC.
PB  - Univerzitet u Beogradu - Medicinski fakultet
T2  - Medicinska Istraživanja
T1  - Role Of Pkc-delta And Erk1/2 In Trombin stimulated vascular smooth muscle cells proliferation
T1  - Uloga PKCd i ERK1/2 u trombinom stimulisanoj proliferaciji glatkih mišićnih ćelija krvnih sudova
VL  - 47
IS  - 1
SP  - 5
EP  - 9
DO  - 10.5937/MedIst1301005S
ER  - 

@article{
author = "Smiljanić, Katarina and Savić, Kristina and Obradovic, Milan and Putniković, Biljana and Đorđević, Jelena and Isenović, Esma",
year = "2013",
abstract = "Kardiovaskularne bolesti predstavljaju najveći uzrok smrtnosti ljudske populacije, a jedna od njihovih najučestalijih patoloških komponenti je i sama ateroskleroza. Proliferacija ili deoba glatkih mišićnih ćelija krvnih sudova (VSMC) ključni je događaj u nastanku raznih vaskularnih oboljenja, uključujući aterosklerozu i hipertenziju. U procesu diferencijacije i abnormalne deobe VSMC povezanih sa hipertenzijom i aterosklerozom uključen je i trombin. Stimulisanje VSMC trombinom dovodi do aktivacije ekstracelularnim signalima regulisanih kinaza 1 i 2 (ERK1/2), preko transaktivacije receptora za epidermalni faktor rasta (EGFR). U našim ranijim studijama potvrdili smo na osnovu inhibicije ERK1/2 od strane PD9805 inhibitora, učešće ERK1/2 u regulaciji proliferacije VSMC izazvanoj trombinom. Takođe, protein kinaza C delta (PKCδ), detektovana je u VSMC i pokazano je da je i njena aktivnost takođe regulisana trombinom. U okviru ovog preglednog članka biće prikazani literaturni podaci koji se odnose na ulogu PKCδ i ERK1/2, u posredovanju proliferativnog efekta trombina na VSMC., Cardiovascular disease is the greatestest single
cause of mortality and its major underlying pathology
is atherosclerosis. The proliferation of vascular smooth
muscle cells (VSMC) is a key event in the pathogenesis
of various vascular diseases, including atherosclerosis
and hypertension. Thrombin is involved in the
differentiation and abnormal proliferation of VSMC
associated with atherosclerosis and hypertension.
Thrombin stimulation results in extracellular
signal-regulated kinase (ERK1/2) activation through
transactivation of the epidermal growth factor receptor
(EGFR). Based on our reacent studies in which
PD98059 used to inhibit ERK1/2, we have shown
previously that ERK1/2 was involved in the regulation
by thrombin of VSMC’s proliferation. In addition,
protein kinase C delta (PKCδ) have also been detected
in VSMC and shown to be regulated by thrombin.
In this review, we are presenting literature data
relating to role of PKCδ and ERK1/2 in mediating the
mitogenic action of thrombin in VSMC.",
publisher = "Univerzitet u Beogradu - Medicinski fakultet",
journal = "Medicinska Istraživanja",
title = "Role Of Pkc-delta And Erk1/2 In Trombin stimulated vascular smooth muscle cells proliferation, Uloga PKCd i ERK1/2 u trombinom stimulisanoj proliferaciji glatkih mišićnih ćelija krvnih sudova",
volume = "47",
number = "1",
pages = "5-9",
doi = "10.5937/MedIst1301005S"
}

Smiljanić, K., Savić, K., Obradovic, M., Putniković, B., Đorđević, J.,& Isenović, E.. (2013). Role Of Pkc-delta And Erk1/2 In Trombin stimulated vascular smooth muscle cells proliferation. in Medicinska Istraživanja
Univerzitet u Beogradu - Medicinski fakultet., 47(1), 5-9.
https://doi.org/10.5937/MedIst1301005S

Smiljanić K, Savić K, Obradovic M, Putniković B, Đorđević J, Isenović E. Role Of Pkc-delta And Erk1/2 In Trombin stimulated vascular smooth muscle cells proliferation. in Medicinska Istraživanja. 2013;47(1):5-9.
doi:10.5937/MedIst1301005S .

Smiljanić, Katarina, Savić, Kristina, Obradovic, Milan, Putniković, Biljana, Đorđević, Jelena, Isenović, Esma, "Role Of Pkc-delta And Erk1/2 In Trombin stimulated vascular smooth muscle cells proliferation" in Medicinska Istraživanja, 47, no. 1 (2013):5-9,
https://doi.org/10.5937/MedIst1301005S . .