TY  - JOUR
AU  - Sabo, Tibor
AU  - Kaluđerović, Goran N.
AU  - Poleti, D
AU  - Karanovic, L
AU  - Boccarelli, A
AU  - Cannito, F
AU  - Natile, G
PY  - 2004
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/655
AB  - The cytotoxicities of two platinum(IV) complexes of formula [PtX(2)(eddp)] - nH(2)O (eddp = ethylenediamine-N,N'-di-3-propionate, X = chloro [11 or bromo [11], n = I or 1.24) are reported. The complexes have been obtained by direct reaction of potassium hexahaloplatinate(IV) with H(2)eddp.2HCl followed by addition of a base (LiOH). The crystal and molecular structure has confirmed that the complex with bromo ligands, similarly to the complex with chloro ligands previously reported, has trans configuration of the halogens. In both the chloro and bromo complexes there appear to be intramolecular N-H... X interactions which account for a narrowing of the corresponding X-Pt-N angles below 90degrees. The trans isomer (configuration index OC-6-13, two nitrogens and two oxygens of eddp bound in the equatorial plane) is the only one obtained in the reaction of hexahaloplatinate(IV) with the eddp ligand while a similar reaction performed with ethylenediamine-N,N'-diacetate (edda) affords exclusively the symmetrical cis-isomer (configuration index OC-6-33, equatorial nitrogen and axial oxygen atoms of edda). The longer chain of the propionato groups (as compared to the acetato ones) is responsible for such a change in preferred configuration. NMR data have revealed a very large diastereotopic splitting of the propionato methylene protons a to the nitrogens (0.88 ppm). The trans disposition of the halogen ligands in the compounds with eddp leads to deactivation of platinum(IV) complexes in comparison to those with edda having cis disposition of the leaving chlorides (human ovarian cancer cell line A2780, IC(50) [muM] of 92.6 +/- 12 and 30.3 +/- 7.5 for [1] and [11], respectively). (C) 2004 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Cytotoxicity of some platinum(IV) complexes with ethylenediamine-N,N'-di-3-propionato ligand
VL  - 98
IS  - 8
SP  - 1378
EP  - 1384
DO  - 10.1016/j.jinorgbio.2004.04.023
ER  - 

@article{
author = "Sabo, Tibor and Kaluđerović, Goran N. and Poleti, D and Karanovic, L and Boccarelli, A and Cannito, F and Natile, G",
year = "2004",
abstract = "The cytotoxicities of two platinum(IV) complexes of formula [PtX(2)(eddp)] - nH(2)O (eddp = ethylenediamine-N,N'-di-3-propionate, X = chloro [11 or bromo [11], n = I or 1.24) are reported. The complexes have been obtained by direct reaction of potassium hexahaloplatinate(IV) with H(2)eddp.2HCl followed by addition of a base (LiOH). The crystal and molecular structure has confirmed that the complex with bromo ligands, similarly to the complex with chloro ligands previously reported, has trans configuration of the halogens. In both the chloro and bromo complexes there appear to be intramolecular N-H... X interactions which account for a narrowing of the corresponding X-Pt-N angles below 90degrees. The trans isomer (configuration index OC-6-13, two nitrogens and two oxygens of eddp bound in the equatorial plane) is the only one obtained in the reaction of hexahaloplatinate(IV) with the eddp ligand while a similar reaction performed with ethylenediamine-N,N'-diacetate (edda) affords exclusively the symmetrical cis-isomer (configuration index OC-6-33, equatorial nitrogen and axial oxygen atoms of edda). The longer chain of the propionato groups (as compared to the acetato ones) is responsible for such a change in preferred configuration. NMR data have revealed a very large diastereotopic splitting of the propionato methylene protons a to the nitrogens (0.88 ppm). The trans disposition of the halogen ligands in the compounds with eddp leads to deactivation of platinum(IV) complexes in comparison to those with edda having cis disposition of the leaving chlorides (human ovarian cancer cell line A2780, IC(50) [muM] of 92.6 +/- 12 and 30.3 +/- 7.5 for [1] and [11], respectively). (C) 2004 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Cytotoxicity of some platinum(IV) complexes with ethylenediamine-N,N'-di-3-propionato ligand",
volume = "98",
number = "8",
pages = "1378-1384",
doi = "10.1016/j.jinorgbio.2004.04.023"
}

Sabo, T., Kaluđerović, G. N., Poleti, D., Karanovic, L., Boccarelli, A., Cannito, F.,& Natile, G.. (2004). Cytotoxicity of some platinum(IV) complexes with ethylenediamine-N,N'-di-3-propionato ligand. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 98(8), 1378-1384.
https://doi.org/10.1016/j.jinorgbio.2004.04.023

Sabo T, Kaluđerović GN, Poleti D, Karanovic L, Boccarelli A, Cannito F, Natile G. Cytotoxicity of some platinum(IV) complexes with ethylenediamine-N,N'-di-3-propionato ligand. in Journal of Inorganic Biochemistry. 2004;98(8):1378-1384.
doi:10.1016/j.jinorgbio.2004.04.023 .

Sabo, Tibor, Kaluđerović, Goran N., Poleti, D, Karanovic, L, Boccarelli, A, Cannito, F, Natile, G, "Cytotoxicity of some platinum(IV) complexes with ethylenediamine-N,N'-di-3-propionato ligand" in Journal of Inorganic Biochemistry, 98, no. 8 (2004):1378-1384,
https://doi.org/10.1016/j.jinorgbio.2004.04.023 . .