Lolić, Aleksandar

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Authority KeyName Variants
orcid::0000-0002-5354-9019
  • Lolić, Aleksandar (38)
Projects
Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200168 (University of Belgrade, Faculty of Chemistry) Development of new and improvement of existing electrochemical, spectroscopic and flow injection (FIA) methods on environmental quality monitoring
Structure-properties relationships of natural and synthetic molecules and their metal complexes European Regional Development Fund (ERDF) through the COMPETE - Operational Competitiveness Programme
Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids COST Action [CA15135]
Estonian Ministry for Education and Research [IUT34-14] German Research Foundation (DFG) [INST 208/664-1 FUGG]
FoodEnTwin-Twinning of research activities for the frontier research in the fields of food, nutrition and environmental omics national funds through FCT - Foundation for Science and Technology [PEst-C/EQB/LA0006/2013, PEst-C/MAR/LA0015/2011]
national funds through FCT - Foundation for Science and Technology [PEst-C/EQB/LA0006/2013, PEst-C/MAR/LA0015/2013] Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazilian Ministry of Science and Technology (CNPq/FCT) [490585/2010-8]
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazilian Ministry of Science and Technology (MCTI/CNPq/MS-SCTIE) [40/2012, 404134/2012-2] Coordenacao de Aperfeicoamento de Pessoal de Nivel Supeior, Brazilian Ministry of Education (CAPES) [705/2009]
DAAD (Germany) Faculdade de Ciencias de Guarulhos FACIG/UNIESP
Fundacao e Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/02282-6] Fundacao para a Ciencia e a Tecnologia (FCT) [PEst-C/EQB/LA0006/2011, PTDC/CTM-NAN/109877/2009]
The synthesis of aminoquinoline-based antimalarials and botulinum neurotoxin A inhibitors Application of advanced oxidation processes and nanostructured oxide materials for the removal of pollutants from the environment, development and optimisation of instrumental techniques for efficiency monitoring
Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology Allergens, antibodies, enzymes and small physiologically important molecules: design, structure, function and relevance
Molecular characterization of thyroid gland tumors:biological and clinical aspects

Author's Bibliography

Supplementary data for the article: Stevanović, N.; Apostolović, D.; Milčić, M.; Lolić, A.; Hage, M. van; Veličković, T. Ć.; Baošić, R. Interaction, Binding Capacity and Anticancer Properties of N,N′-Bis(Acetylacetone)-Propylenediimine-Copper(II) on Colorectal Cancer Cell Line Caco-2. New J. Chem. 2021, 45 (14), 6231–6237. https://doi.org/10.1039/D1NJ00040C.

Stevanović, Nikola R.; Apostolović, Danijela; Milčić, Miloš K.; Lolić, Aleksandar; Hage, Marianne van; Ćirković-Veličković, Tanja; Baošić, Rada

(2021)

TY  - DATA
AU  - Stevanović, Nikola R.
AU  - Apostolović, Danijela
AU  - Milčić, Miloš K.
AU  - Lolić, Aleksandar
AU  - Hage, Marianne van
AU  - Ćirković-Veličković, Tanja
AU  - Baošić, Rada
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4400
T2  - New Journal of Chemistry
T1  - Supplementary data for the article: Stevanović, N.; Apostolović, D.; Milčić, M.; Lolić, A.; Hage, M. van; Veličković, T. Ć.; Baošić, R. Interaction, Binding Capacity and Anticancer Properties of N,N′-Bis(Acetylacetone)-Propylenediimine-Copper(II) on Colorectal Cancer Cell Line Caco-2. New J. Chem. 2021, 45 (14), 6231–6237. https://doi.org/10.1039/D1NJ00040C.
ER  - 
@misc{
author = "Stevanović, Nikola R. and Apostolović, Danijela and Milčić, Miloš K. and Lolić, Aleksandar and Hage, Marianne van and Ćirković-Veličković, Tanja and Baošić, Rada",
year = "2021",
journal = "New Journal of Chemistry",
title = "Supplementary data for the article: Stevanović, N.; Apostolović, D.; Milčić, M.; Lolić, A.; Hage, M. van; Veličković, T. Ć.; Baošić, R. Interaction, Binding Capacity and Anticancer Properties of N,N′-Bis(Acetylacetone)-Propylenediimine-Copper(II) on Colorectal Cancer Cell Line Caco-2. New J. Chem. 2021, 45 (14), 6231–6237. https://doi.org/10.1039/D1NJ00040C."
}
Stevanović, N. R., Apostolović, D., Milčić, M. K., Lolić, A., Hage, M. v., Ćirković-Veličković, T.,& Baošić, R.. (2021). Supplementary data for the article: Stevanović, N.; Apostolović, D.; Milčić, M.; Lolić, A.; Hage, M. van; Veličković, T. Ć.; Baošić, R. Interaction, Binding Capacity and Anticancer Properties of N,N′-Bis(Acetylacetone)-Propylenediimine-Copper(II) on Colorectal Cancer Cell Line Caco-2. New J. Chem. 2021, 45 (14), 6231–6237. https://doi.org/10.1039/D1NJ00040C.. in New Journal of Chemistry.
Stevanović NR, Apostolović D, Milčić MK, Lolić A, Hage MV, Ćirković-Veličković T, Baošić R. Supplementary data for the article: Stevanović, N.; Apostolović, D.; Milčić, M.; Lolić, A.; Hage, M. van; Veličković, T. Ć.; Baošić, R. Interaction, Binding Capacity and Anticancer Properties of N,N′-Bis(Acetylacetone)-Propylenediimine-Copper(II) on Colorectal Cancer Cell Line Caco-2. New J. Chem. 2021, 45 (14), 6231–6237. https://doi.org/10.1039/D1NJ00040C.. in New Journal of Chemistry. 2021;..
Stevanović, Nikola R., Apostolović, Danijela, Milčić, Miloš K., Lolić, Aleksandar, Hage, Marianne van, Ćirković-Veličković, Tanja, Baošić, Rada, "Supplementary data for the article: Stevanović, N.; Apostolović, D.; Milčić, M.; Lolić, A.; Hage, M. van; Veličković, T. Ć.; Baošić, R. Interaction, Binding Capacity and Anticancer Properties of N,N′-Bis(Acetylacetone)-Propylenediimine-Copper(II) on Colorectal Cancer Cell Line Caco-2. New J. Chem. 2021, 45 (14), 6231–6237. https://doi.org/10.1039/D1NJ00040C." in New Journal of Chemistry (2021).

Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2

Stevanović, Nikola R.; Apostolović, Danijela; Milčić, Miloš K.; Lolić, Aleksandar; Hage, Marianne van; Ćirković-Veličković, Tanja; Baošić, Rada

(2021)

TY  - JOUR
AU  - Stevanović, Nikola R.
AU  - Apostolović, Danijela
AU  - Milčić, Miloš K.
AU  - Lolić, Aleksandar
AU  - Hage, Marianne van
AU  - Ćirković-Veličković, Tanja
AU  - Baošić, Rada
PY  - 2021
UR  - https://pubs.rsc.org/en/content/articlelanding/2021/nj/d1nj00040c
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4399
AB  - Different Schiff base complexes have biological activities that make them suitable for drug design. The biological properties of tetradentate Schiff base copper(II) complexed with N,N′-bis(acetylacetone)propylenediimine have been studied. The cytotoxic activity towards Caco-2 cells were determined by MTT, Anexin V and PI apoptosis assays. N,N′-bis(acetylacetone)propylenediimine-copper(II) showed the anti-cancer and anti-proliferative properties by inducing apoptosis in Caco-2 cells. A comparison of the cytotoxic activity of this compound with cisplatin shows that it is more effective on the colorectal cancer cell line Caco-2. The binding capacity and interaction of N,N′-bis(acetylacetone)propylenediimine-copper(II) with HSA were systemically investigated by in vitro fluorescence spectroscopy, CD spectroscopy, and in silico molecular docking study. Furthermore, in vitro and in silico interaction studies indicated that the complex binds to HSA through a static quenching mechanism without changes in protein conformation. The calculated number of binding sites was in line with molecular docking studies. The obtained Ka value suggests that the compound can be released from the protein in target cells. The tetradentate Schiff base copper(II) complex exhibited in vitro biological activities against cancer epithelial cells, which depend on the molecular structure of the complex, causing apoptosis, and the complex can bind to the protein drug carrier in circulation to the target tissue.
T2  - New Journal of Chemistry
T1  - Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2
VL  - 45
IS  - 14
SP  - 6231
EP  - 6237
DO  - 10.1039/D1NJ00040C
ER  - 
@article{
author = "Stevanović, Nikola R. and Apostolović, Danijela and Milčić, Miloš K. and Lolić, Aleksandar and Hage, Marianne van and Ćirković-Veličković, Tanja and Baošić, Rada",
year = "2021",
abstract = "Different Schiff base complexes have biological activities that make them suitable for drug design. The biological properties of tetradentate Schiff base copper(II) complexed with N,N′-bis(acetylacetone)propylenediimine have been studied. The cytotoxic activity towards Caco-2 cells were determined by MTT, Anexin V and PI apoptosis assays. N,N′-bis(acetylacetone)propylenediimine-copper(II) showed the anti-cancer and anti-proliferative properties by inducing apoptosis in Caco-2 cells. A comparison of the cytotoxic activity of this compound with cisplatin shows that it is more effective on the colorectal cancer cell line Caco-2. The binding capacity and interaction of N,N′-bis(acetylacetone)propylenediimine-copper(II) with HSA were systemically investigated by in vitro fluorescence spectroscopy, CD spectroscopy, and in silico molecular docking study. Furthermore, in vitro and in silico interaction studies indicated that the complex binds to HSA through a static quenching mechanism without changes in protein conformation. The calculated number of binding sites was in line with molecular docking studies. The obtained Ka value suggests that the compound can be released from the protein in target cells. The tetradentate Schiff base copper(II) complex exhibited in vitro biological activities against cancer epithelial cells, which depend on the molecular structure of the complex, causing apoptosis, and the complex can bind to the protein drug carrier in circulation to the target tissue.",
journal = "New Journal of Chemistry",
title = "Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2",
volume = "45",
number = "14",
pages = "6231-6237",
doi = "10.1039/D1NJ00040C"
}
Stevanović, N. R., Apostolović, D., Milčić, M. K., Lolić, A., Hage, M. v., Ćirković-Veličković, T.,& Baošić, R.. (2021). Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2. in New Journal of Chemistry, 45(14), 6231-6237.
https://doi.org/10.1039/D1NJ00040C
Stevanović NR, Apostolović D, Milčić MK, Lolić A, Hage MV, Ćirković-Veličković T, Baošić R. Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2. in New Journal of Chemistry. 2021;45(14):6231-6237.
doi:10.1039/D1NJ00040C .
Stevanović, Nikola R., Apostolović, Danijela, Milčić, Miloš K., Lolić, Aleksandar, Hage, Marianne van, Ćirković-Veličković, Tanja, Baošić, Rada, "Interaction, binding capacity and anticancer properties of N,N′-bis(acetylacetone)-propylenediimine-copper(II) on colorectal cancer cell line Caco-2" in New Journal of Chemistry, 45, no. 14 (2021):6231-6237,
https://doi.org/10.1039/D1NJ00040C . .

Novel approach to the measurement of antithyroglobulin antibodies in human serum – application of the quartz crystal microbalance sensors

Vrhovac, Lidija; Šelemetjev, Sonja A.; Vatić, Saša; Mitrović, Aleksandar; Milošević, Jelica; Lolić, Aleksandar; Beletić, Anđelo D.; Polović, Natalija

(Elsevier, 2021)

TY  - JOUR
AU  - Vrhovac, Lidija
AU  - Šelemetjev, Sonja A.
AU  - Vatić, Saša
AU  - Mitrović, Aleksandar
AU  - Milošević, Jelica
AU  - Lolić, Aleksandar
AU  - Beletić, Anđelo D.
AU  - Polović, Natalija
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4295
AB  - Measurement of antithyroglobulin antibodies (TgAb) is an inevitable laboratory tool in the management of thyroid gland diseases. Currently available immunoassays still have limitations underlying the necessity of the introduction of fast, sensitive, and label-free technologies. Our aim was to develop a method for TgAb measurement in human serum based on the quartz crystal microbalance (QCM) technology. We immobilized thyroglobulin on the surface of Attana LNB Carboxyl sensor chip®, prepared standard curve covering the range of 1–50000 kIU/L, and established optimal measurement conditions. The validation included determination of the detection limit (LOD), functional sensitivity, linearity, precision, as well as the comparison with the results of the radioimmunoassay (RIA). The LOD and functional sensitivity were 4.2 kIU/L and 4.7 kIU/L, respectively. The method was linear in the range of 20–10000 kIU/L. The regression equation for comparison with RIA was CQCM = 1.0056 • CRIA – 24.2778, whereby no significant proportional or systematic difference was present. There was a good agreement with RIA in the classification of patients according to the clinical significance of the results. The developed method has advantages over currently available assays in terms of better LOQ, a higher upper limit of linearity, and precision. The characteristics of the developed method unambiguously show that the application of the QCM biosensors offers a highly reliable novel approach for the measurement of TgAb in human serum.
PB  - Elsevier
T2  - Talanta
T1  - Novel approach to the measurement of antithyroglobulin antibodies in human serum – application of the quartz crystal microbalance sensors
VL  - 223
SP  - 121588
DO  - 10.1016/j.talanta.2020.121588
ER  - 
@article{
author = "Vrhovac, Lidija and Šelemetjev, Sonja A. and Vatić, Saša and Mitrović, Aleksandar and Milošević, Jelica and Lolić, Aleksandar and Beletić, Anđelo D. and Polović, Natalija",
year = "2021",
abstract = "Measurement of antithyroglobulin antibodies (TgAb) is an inevitable laboratory tool in the management of thyroid gland diseases. Currently available immunoassays still have limitations underlying the necessity of the introduction of fast, sensitive, and label-free technologies. Our aim was to develop a method for TgAb measurement in human serum based on the quartz crystal microbalance (QCM) technology. We immobilized thyroglobulin on the surface of Attana LNB Carboxyl sensor chip®, prepared standard curve covering the range of 1–50000 kIU/L, and established optimal measurement conditions. The validation included determination of the detection limit (LOD), functional sensitivity, linearity, precision, as well as the comparison with the results of the radioimmunoassay (RIA). The LOD and functional sensitivity were 4.2 kIU/L and 4.7 kIU/L, respectively. The method was linear in the range of 20–10000 kIU/L. The regression equation for comparison with RIA was CQCM = 1.0056 • CRIA – 24.2778, whereby no significant proportional or systematic difference was present. There was a good agreement with RIA in the classification of patients according to the clinical significance of the results. The developed method has advantages over currently available assays in terms of better LOQ, a higher upper limit of linearity, and precision. The characteristics of the developed method unambiguously show that the application of the QCM biosensors offers a highly reliable novel approach for the measurement of TgAb in human serum.",
publisher = "Elsevier",
journal = "Talanta",
title = "Novel approach to the measurement of antithyroglobulin antibodies in human serum – application of the quartz crystal microbalance sensors",
volume = "223",
pages = "121588",
doi = "10.1016/j.talanta.2020.121588"
}
Vrhovac, L., Šelemetjev, S. A., Vatić, S., Mitrović, A., Milošević, J., Lolić, A., Beletić, A. D.,& Polović, N.. (2021). Novel approach to the measurement of antithyroglobulin antibodies in human serum – application of the quartz crystal microbalance sensors. in Talanta
Elsevier., 223, 121588.
https://doi.org/10.1016/j.talanta.2020.121588
Vrhovac L, Šelemetjev SA, Vatić S, Mitrović A, Milošević J, Lolić A, Beletić AD, Polović N. Novel approach to the measurement of antithyroglobulin antibodies in human serum – application of the quartz crystal microbalance sensors. in Talanta. 2021;223:121588.
doi:10.1016/j.talanta.2020.121588 .
Vrhovac, Lidija, Šelemetjev, Sonja A., Vatić, Saša, Mitrović, Aleksandar, Milošević, Jelica, Lolić, Aleksandar, Beletić, Anđelo D., Polović, Natalija, "Novel approach to the measurement of antithyroglobulin antibodies in human serum – application of the quartz crystal microbalance sensors" in Talanta, 223 (2021):121588,
https://doi.org/10.1016/j.talanta.2020.121588 . .
1
1
1

One-step purification and freeze stability of papain at acidic pH values

Marković, Srđan; Milošević, Jelica; Đurić, Milica; Lolić, Aleksandar; Polović, Natalija

(2021)

TY  - JOUR
AU  - Marković, Srđan
AU  - Milošević, Jelica
AU  - Đurić, Milica
AU  - Lolić, Aleksandar
AU  - Polović, Natalija
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4479
AB  - Papain is a proteolytic enzyme of great commercial value. It is a cysteine protease highly expressed in Carica papaya fruit latex, but also present in papaya leaves. Purification procedures mostly deal with the latex and include a combination of precipitation and/or chromatographic techniques. Due to its solubility, structure and activity characteristics, the pH and salt content play significant roles in handling papain extracts. Here we report a simple, rapid and easily scalable procedure for papain purification from papaya leaves, which contain different contaminants as compared to papaya latex. Sodium chloride precipitation of contaminants at pH 5 followed by ammonium sulphate precipitation resulted in the removal of other leaf proteins and protein fragments from papain solution and about a 3-fold purification. The procedure also benefits from the suppression of autoproteolysis and preservation of the native structure, as confirmed by FTIR analysis, and the high recovery of activity of over 80%.
T2  - Archives of Biological Sciences
T1  - One-step purification and freeze stability of papain at acidic pH values
VL  - 73
IS  - 1
SP  - 57
EP  - 64
DO  - 10.2298/ABS201217001M
ER  - 
@article{
author = "Marković, Srđan and Milošević, Jelica and Đurić, Milica and Lolić, Aleksandar and Polović, Natalija",
year = "2021",
abstract = "Papain is a proteolytic enzyme of great commercial value. It is a cysteine protease highly expressed in Carica papaya fruit latex, but also present in papaya leaves. Purification procedures mostly deal with the latex and include a combination of precipitation and/or chromatographic techniques. Due to its solubility, structure and activity characteristics, the pH and salt content play significant roles in handling papain extracts. Here we report a simple, rapid and easily scalable procedure for papain purification from papaya leaves, which contain different contaminants as compared to papaya latex. Sodium chloride precipitation of contaminants at pH 5 followed by ammonium sulphate precipitation resulted in the removal of other leaf proteins and protein fragments from papain solution and about a 3-fold purification. The procedure also benefits from the suppression of autoproteolysis and preservation of the native structure, as confirmed by FTIR analysis, and the high recovery of activity of over 80%.",
journal = "Archives of Biological Sciences",
title = "One-step purification and freeze stability of papain at acidic pH values",
volume = "73",
number = "1",
pages = "57-64",
doi = "10.2298/ABS201217001M"
}
Marković, S., Milošević, J., Đurić, M., Lolić, A.,& Polović, N.. (2021). One-step purification and freeze stability of papain at acidic pH values. in Archives of Biological Sciences, 73(1), 57-64.
https://doi.org/10.2298/ABS201217001M
Marković S, Milošević J, Đurić M, Lolić A, Polović N. One-step purification and freeze stability of papain at acidic pH values. in Archives of Biological Sciences. 2021;73(1):57-64.
doi:10.2298/ABS201217001M .
Marković, Srđan, Milošević, Jelica, Đurić, Milica, Lolić, Aleksandar, Polović, Natalija, "One-step purification and freeze stability of papain at acidic pH values" in Archives of Biological Sciences, 73, no. 1 (2021):57-64,
https://doi.org/10.2298/ABS201217001M . .

Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases

Stevanović, Nikola; Mijatović, Aleksandar; Lolić, Aleksandar; Zlatović, Mario; Baošić, Rada

(Springer, 2021)

TY  - JOUR
AU  - Stevanović, Nikola
AU  - Mijatović, Aleksandar
AU  - Lolić, Aleksandar
AU  - Zlatović, Mario
AU  - Baošić, Rada
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4707
AB  - The influences of the application of mono- and two-component organic modifiers on lipophilicity determination of 12 tetradentate Schiff bases by reversed-phase thin layer chromatography were investigated. The main goal is to estimate types of interaction between observed compounds and components of the applied chromatographic systems and establish some behaviour pattern in order to easier choose a combination of organic modifiers which will simulate interaction in biological systems based on the facts that the same basic intermolecular interactions are responsible for the behaviour of substances in both the biological and chromatographic system. The applied organic modifier shows the ability to modify the surface of the applied sorbent, which affects the manifestation of lipophilicity of the observed compounds. Mono-component organic modifiers from different groups of the Snyder triangle were used, as well as their two-component mixtures. In addition, we compared experimentally determined calculated parameters of lipophilicity.
PB  - Springer
T2  - Chemical Papers
T1  - Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases
DO  - 10.1007/s11696-021-01884-5
ER  - 
@article{
author = "Stevanović, Nikola and Mijatović, Aleksandar and Lolić, Aleksandar and Zlatović, Mario and Baošić, Rada",
year = "2021",
abstract = "The influences of the application of mono- and two-component organic modifiers on lipophilicity determination of 12 tetradentate Schiff bases by reversed-phase thin layer chromatography were investigated. The main goal is to estimate types of interaction between observed compounds and components of the applied chromatographic systems and establish some behaviour pattern in order to easier choose a combination of organic modifiers which will simulate interaction in biological systems based on the facts that the same basic intermolecular interactions are responsible for the behaviour of substances in both the biological and chromatographic system. The applied organic modifier shows the ability to modify the surface of the applied sorbent, which affects the manifestation of lipophilicity of the observed compounds. Mono-component organic modifiers from different groups of the Snyder triangle were used, as well as their two-component mixtures. In addition, we compared experimentally determined calculated parameters of lipophilicity.",
publisher = "Springer",
journal = "Chemical Papers",
title = "Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases",
doi = "10.1007/s11696-021-01884-5"
}
Stevanović, N., Mijatović, A., Lolić, A., Zlatović, M.,& Baošić, R.. (2021). Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases. in Chemical Papers
Springer..
https://doi.org/10.1007/s11696-021-01884-5
Stevanović N, Mijatović A, Lolić A, Zlatović M, Baošić R. Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases. in Chemical Papers. 2021;.
doi:10.1007/s11696-021-01884-5 .
Stevanović, Nikola, Mijatović, Aleksandar, Lolić, Aleksandar, Zlatović, Mario, Baošić, Rada, "Influence of mono- and two-component organic modifiers on determination of lipophilicity of tetradentate Schiff bases" in Chemical Papers (2021),
https://doi.org/10.1007/s11696-021-01884-5 . .

Evaluation of LC-MS/MS methodology for determination of 179 multi-class pesticides in cabbage and rice by modified QuEChERS extraction

Kecojević, Isidora; Đekić, Sanja; Lazović, Milana; Mrkajić, Danica; Baošić, Rada; Lolić, Aleksandar

(Elsevier, 2021)

TY  - JOUR
AU  - Kecojević, Isidora
AU  - Đekić, Sanja
AU  - Lazović, Milana
AU  - Mrkajić, Danica
AU  - Baošić, Rada
AU  - Lolić, Aleksandar
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S0956713520306095
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4433
AB  - A method using modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) without clean-up step based on the sample dilution approach followed by the liquid chromatography coupled with the tandem mass spectrometry (LC-MS/MS) has been established for determination of 179 pesticide residues in cabbage and rice samples. Two different LC columns were used and their sensitivity was investigated regarding the sample volume. Evaluation of the matrix effect in context of sample dilution and applied extraction solvents was investigated. The method was validated according to Document SANTE/12682/2019. For cabbage samples, recoveries were 70–120% for concentration level of 5 μg/kg; and 70–115% for concentration level of 50 μg/kg; precision RSDr <17%; limits of detection and quantification were in the ranges of 0.4–5.5 and 1.2–16.7 μg/kg, respectively. For rice samples, recoveries were 70–109% for 10 μg/kg concentration; 70–115% for 100 μg/kg concentration; precision RSDr <14%, while limits of detection and quantification were in the ranges of 0.5–4.2 and 1.5–12.7 μg/kg, respectively.
PB  - Elsevier
T2  - Food Control
T1  - Evaluation of LC-MS/MS methodology for determination of 179 multi-class pesticides in cabbage and rice by modified QuEChERS extraction
VL  - 123
SP  - 107693
DO  - 10.1016/j.foodcont.2020.107693
ER  - 
@article{
author = "Kecojević, Isidora and Đekić, Sanja and Lazović, Milana and Mrkajić, Danica and Baošić, Rada and Lolić, Aleksandar",
year = "2021",
abstract = "A method using modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) without clean-up step based on the sample dilution approach followed by the liquid chromatography coupled with the tandem mass spectrometry (LC-MS/MS) has been established for determination of 179 pesticide residues in cabbage and rice samples. Two different LC columns were used and their sensitivity was investigated regarding the sample volume. Evaluation of the matrix effect in context of sample dilution and applied extraction solvents was investigated. The method was validated according to Document SANTE/12682/2019. For cabbage samples, recoveries were 70–120% for concentration level of 5 μg/kg; and 70–115% for concentration level of 50 μg/kg; precision RSDr <17%; limits of detection and quantification were in the ranges of 0.4–5.5 and 1.2–16.7 μg/kg, respectively. For rice samples, recoveries were 70–109% for 10 μg/kg concentration; 70–115% for 100 μg/kg concentration; precision RSDr <14%, while limits of detection and quantification were in the ranges of 0.5–4.2 and 1.5–12.7 μg/kg, respectively.",
publisher = "Elsevier",
journal = "Food Control",
title = "Evaluation of LC-MS/MS methodology for determination of 179 multi-class pesticides in cabbage and rice by modified QuEChERS extraction",
volume = "123",
pages = "107693",
doi = "10.1016/j.foodcont.2020.107693"
}
Kecojević, I., Đekić, S., Lazović, M., Mrkajić, D., Baošić, R.,& Lolić, A.. (2021). Evaluation of LC-MS/MS methodology for determination of 179 multi-class pesticides in cabbage and rice by modified QuEChERS extraction. in Food Control
Elsevier., 123, 107693.
https://doi.org/10.1016/j.foodcont.2020.107693
Kecojević I, Đekić S, Lazović M, Mrkajić D, Baošić R, Lolić A. Evaluation of LC-MS/MS methodology for determination of 179 multi-class pesticides in cabbage and rice by modified QuEChERS extraction. in Food Control. 2021;123:107693.
doi:10.1016/j.foodcont.2020.107693 .
Kecojević, Isidora, Đekić, Sanja, Lazović, Milana, Mrkajić, Danica, Baošić, Rada, Lolić, Aleksandar, "Evaluation of LC-MS/MS methodology for determination of 179 multi-class pesticides in cabbage and rice by modified QuEChERS extraction" in Food Control, 123 (2021):107693,
https://doi.org/10.1016/j.foodcont.2020.107693 . .
3
4
4

Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations

Antunović, Vesna R.; Baošić, Rada; Lolić, Aleksandar

(Bentham Science, 2021)

TY  - JOUR
AU  - Antunović, Vesna R.
AU  - Baošić, Rada
AU  - Lolić, Aleksandar
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4401
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4402
AB  - Background: Diazepam belongs to the group of 1,4-benzodiapines. It is used for the treatment of anxiety, convulsions and as a muscle relaxant. The presence of 4,5-azomethine group enables its electrochemical detection.Introduction: A screen-printed electrode modified with antimony film was used for the determination of diazepam in pharmaceutical preparationsMethods: Electrode modification was done by ex-situ deposition of antimony on commercially available screen-printed electrode. Parameters affecting the electroanalytical response of the sensor, such as deposition potential, deposition time, and antimony concentration, were examined and optimized. The modified electrode showed enhanced electroactivity for diazepam reduction compared to unmodified electrode. Under optimal conditions, linear sweep voltammetry was used for the determination of analyte.Results: The sensor showed linear dependence in the range from 0.5 to 10 μmol/L, the correlation coefficient was 0.9992. The limit of detection was 0.33 μmol/L, corresponding limit of quantification was 1.08 μmol/L. Modification enabled determination of diazepam in the presence of oxygen. Conclusion: The modified electrode was used for the determination of diazepam in tablets. Results confirmed the applicability of the electrochemical sensor.
PB  - Bentham Science
T2  - Current Pharmaceutical Analysis
T1  - Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations
VL  - 17
IS  - 7
SP  - 945
EP  - 950
DO  - 10.2174/1573412916999200730234925
ER  - 
@article{
author = "Antunović, Vesna R. and Baošić, Rada and Lolić, Aleksandar",
year = "2021",
abstract = "Background: Diazepam belongs to the group of 1,4-benzodiapines. It is used for the treatment of anxiety, convulsions and as a muscle relaxant. The presence of 4,5-azomethine group enables its electrochemical detection.Introduction: A screen-printed electrode modified with antimony film was used for the determination of diazepam in pharmaceutical preparationsMethods: Electrode modification was done by ex-situ deposition of antimony on commercially available screen-printed electrode. Parameters affecting the electroanalytical response of the sensor, such as deposition potential, deposition time, and antimony concentration, were examined and optimized. The modified electrode showed enhanced electroactivity for diazepam reduction compared to unmodified electrode. Under optimal conditions, linear sweep voltammetry was used for the determination of analyte.Results: The sensor showed linear dependence in the range from 0.5 to 10 μmol/L, the correlation coefficient was 0.9992. The limit of detection was 0.33 μmol/L, corresponding limit of quantification was 1.08 μmol/L. Modification enabled determination of diazepam in the presence of oxygen. Conclusion: The modified electrode was used for the determination of diazepam in tablets. Results confirmed the applicability of the electrochemical sensor.",
publisher = "Bentham Science",
journal = "Current Pharmaceutical Analysis",
title = "Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations",
volume = "17",
number = "7",
pages = "945-950",
doi = "10.2174/1573412916999200730234925"
}
Antunović, V. R., Baošić, R.,& Lolić, A.. (2021). Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations. in Current Pharmaceutical Analysis
Bentham Science., 17(7), 945-950.
https://doi.org/10.2174/1573412916999200730234925
Antunović VR, Baošić R, Lolić A. Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations. in Current Pharmaceutical Analysis. 2021;17(7):945-950.
doi:10.2174/1573412916999200730234925 .
Antunović, Vesna R., Baošić, Rada, Lolić, Aleksandar, "Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations" in Current Pharmaceutical Analysis, 17, no. 7 (2021):945-950,
https://doi.org/10.2174/1573412916999200730234925 . .

Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations

Antunović, Vesna R.; Baošić, Rada; Lolić, Aleksandar

(Bentham Science, 2021)

TY  - JOUR
AU  - Antunović, Vesna R.
AU  - Baošić, Rada
AU  - Lolić, Aleksandar
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4401
AB  - Background: Diazepam belongs to the group of 1,4-benzodiapines. It is used for the treatment of anxiety, convulsions and as a muscle relaxant. The presence of 4,5-azomethine group enables its electrochemical detection.

Introduction: A screen-printed electrode modified with antimony film was used for the determination of diazepam in pharmaceutical preparations

Methods: Electrode modification was done by ex-situ deposition of antimony on commercially available screen-printed electrode. Parameters affecting the electroanalytical response of the sensor, such as deposition potential, deposition time, and antimony concentration, were examined and optimized. The modified electrode showed enhanced electroactivity for diazepam reduction compared to unmodified electrode. Under optimal conditions, linear sweep voltammetry was used for the determination of analyte.

Results: The sensor showed linear dependence in the range from 0.5 to 10 μmol/L, the correlation coefficient was 0.9992. The limit of detection was 0.33 μmol/L, corresponding limit of quantification was 1.08 μmol/L. Modification enabled determination of diazepam in the presence of oxygen. 

Conclusion: The modified electrode was used for the determination of diazepam in tablets. Results confirmed the applicability of the electrochemical sensor.
PB  - Bentham Science
T2  - Current Pharmaceutical Analysis
T1  - Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations
VL  - 17
IS  - 7
SP  - 945
EP  - 950
DO  - 10.2174/1573412916999200730234925
ER  - 
@article{
author = "Antunović, Vesna R. and Baošić, Rada and Lolić, Aleksandar",
year = "2021",
abstract = "Background: Diazepam belongs to the group of 1,4-benzodiapines. It is used for the treatment of anxiety, convulsions and as a muscle relaxant. The presence of 4,5-azomethine group enables its electrochemical detection.

Introduction: A screen-printed electrode modified with antimony film was used for the determination of diazepam in pharmaceutical preparations

Methods: Electrode modification was done by ex-situ deposition of antimony on commercially available screen-printed electrode. Parameters affecting the electroanalytical response of the sensor, such as deposition potential, deposition time, and antimony concentration, were examined and optimized. The modified electrode showed enhanced electroactivity for diazepam reduction compared to unmodified electrode. Under optimal conditions, linear sweep voltammetry was used for the determination of analyte.

Results: The sensor showed linear dependence in the range from 0.5 to 10 μmol/L, the correlation coefficient was 0.9992. The limit of detection was 0.33 μmol/L, corresponding limit of quantification was 1.08 μmol/L. Modification enabled determination of diazepam in the presence of oxygen. 

Conclusion: The modified electrode was used for the determination of diazepam in tablets. Results confirmed the applicability of the electrochemical sensor.",
publisher = "Bentham Science",
journal = "Current Pharmaceutical Analysis",
title = "Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations",
volume = "17",
number = "7",
pages = "945-950",
doi = "10.2174/1573412916999200730234925"
}
Antunović, V. R., Baošić, R.,& Lolić, A.. (2021). Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations. in Current Pharmaceutical Analysis
Bentham Science., 17(7), 945-950.
https://doi.org/10.2174/1573412916999200730234925
Antunović VR, Baošić R, Lolić A. Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations. in Current Pharmaceutical Analysis. 2021;17(7):945-950.
doi:10.2174/1573412916999200730234925 .
Antunović, Vesna R., Baošić, Rada, Lolić, Aleksandar, "Voltammetric determination of diazepam on antimony film screen-printed electrode in pharmaceutical formulations" in Current Pharmaceutical Analysis, 17, no. 7 (2021):945-950,
https://doi.org/10.2174/1573412916999200730234925 . .

Supplementary data for the article: Kecojević, I.; Đekić, S.; Lazović, M.; Mrkajić, D.; Baošić, R.; Lolić, A. Evaluation of LC-MS/MS Methodology for Determination of 179 Multi-Class Pesticides in Cabbage and Rice by Modified QuEChERS Extraction. Food Control 2021, 123, 107693. https://doi.org/10.1016/j.foodcont.2020.107693.

Kecojević, Isidora; Đekić, Sanja; Lazović, Milana; Mrkajić, Danica; Baošić, Rada; Lolić, Aleksandar

(Elsevier, 2021)

TY  - DATA
AU  - Kecojević, Isidora
AU  - Đekić, Sanja
AU  - Lazović, Milana
AU  - Mrkajić, Danica
AU  - Baošić, Rada
AU  - Lolić, Aleksandar
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4434
PB  - Elsevier
T2  - Food Control
T1  - Supplementary data for the article: Kecojević, I.; Đekić, S.; Lazović, M.; Mrkajić, D.; Baošić, R.; Lolić, A. Evaluation of LC-MS/MS Methodology for Determination of 179 Multi-Class Pesticides in Cabbage and Rice by Modified QuEChERS Extraction. Food Control 2021, 123, 107693. https://doi.org/10.1016/j.foodcont.2020.107693.
ER  - 
@misc{
author = "Kecojević, Isidora and Đekić, Sanja and Lazović, Milana and Mrkajić, Danica and Baošić, Rada and Lolić, Aleksandar",
year = "2021",
publisher = "Elsevier",
journal = "Food Control",
title = "Supplementary data for the article: Kecojević, I.; Đekić, S.; Lazović, M.; Mrkajić, D.; Baošić, R.; Lolić, A. Evaluation of LC-MS/MS Methodology for Determination of 179 Multi-Class Pesticides in Cabbage and Rice by Modified QuEChERS Extraction. Food Control 2021, 123, 107693. https://doi.org/10.1016/j.foodcont.2020.107693."
}
Kecojević, I., Đekić, S., Lazović, M., Mrkajić, D., Baošić, R.,& Lolić, A.. (2021). Supplementary data for the article: Kecojević, I.; Đekić, S.; Lazović, M.; Mrkajić, D.; Baošić, R.; Lolić, A. Evaluation of LC-MS/MS Methodology for Determination of 179 Multi-Class Pesticides in Cabbage and Rice by Modified QuEChERS Extraction. Food Control 2021, 123, 107693. https://doi.org/10.1016/j.foodcont.2020.107693.. in Food Control
Elsevier..
Kecojević I, Đekić S, Lazović M, Mrkajić D, Baošić R, Lolić A. Supplementary data for the article: Kecojević, I.; Đekić, S.; Lazović, M.; Mrkajić, D.; Baošić, R.; Lolić, A. Evaluation of LC-MS/MS Methodology for Determination of 179 Multi-Class Pesticides in Cabbage and Rice by Modified QuEChERS Extraction. Food Control 2021, 123, 107693. https://doi.org/10.1016/j.foodcont.2020.107693.. in Food Control. 2021;..
Kecojević, Isidora, Đekić, Sanja, Lazović, Milana, Mrkajić, Danica, Baošić, Rada, Lolić, Aleksandar, "Supplementary data for the article: Kecojević, I.; Đekić, S.; Lazović, M.; Mrkajić, D.; Baošić, R.; Lolić, A. Evaluation of LC-MS/MS Methodology for Determination of 179 Multi-Class Pesticides in Cabbage and Rice by Modified QuEChERS Extraction. Food Control 2021, 123, 107693. https://doi.org/10.1016/j.foodcont.2020.107693." in Food Control (2021).

Application of N,N’-Bis(acetylacetonato)propylenediimine Copper(II) Complex as Mediator for Glucose Biosensor

Perušković, Danica S.; Stevanović, Nikola R.; Kovačević, Gordana; Stanković, Dalibor; Lolić, Aleksandar; Baošić, Rada

(Wiley-Blackwell, 2020)

TY  - JOUR
AU  - Perušković, Danica S.
AU  - Stevanović, Nikola R.
AU  - Kovačević, Gordana
AU  - Stanković, Dalibor
AU  - Lolić, Aleksandar
AU  - Baošić, Rada
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3976
AB  - A new glucose biosensor for selective and sensitive determination of glucose in beverage samples was developed. A copper complex with a Schiff base, N,N’-bis(acetylacetonato) propylenediimine, was used as a mediator. It was mixed with glucose oxidase (GOx) and prepared as carbon paste electrode (CPE). Cyclic voltammetry was used for electrochemical measurements. The biosensor showed improved sensitivity when enzyme mediator ratio was 1 : 5, and working pH was 6.6 in 0.1 M phosphate buffer. The linear response of the biosensor for glucose concentration was in the range from 0.5 to 10 mM, with low detection limit of 0.36 mM (calculated as 3 s/n) and sensitivity of 0.16 μA/mM. The reproducibility of the biosensor, calculated as relative standard deviation, was 1.9% for 6 intra-day measurements. Biosensor was stored at +4 °C between experiments, and it was stable during 14 days after the preparation. The developed biosensor was applied on determination of glucose in commercial beverages (apple and cherry juice) and obtained results showed good agreement with the reference method.
PB  - Wiley-Blackwell
T2  - ChemistrySelect
T1  - Application of N,N’-Bis(acetylacetonato)propylenediimine Copper(II) Complex as Mediator for Glucose Biosensor
VL  - 5
IS  - 5
SP  - 1671
EP  - 1675
DO  - 10.1002/slct.201904873
ER  - 
@article{
author = "Perušković, Danica S. and Stevanović, Nikola R. and Kovačević, Gordana and Stanković, Dalibor and Lolić, Aleksandar and Baošić, Rada",
year = "2020",
abstract = "A new glucose biosensor for selective and sensitive determination of glucose in beverage samples was developed. A copper complex with a Schiff base, N,N’-bis(acetylacetonato) propylenediimine, was used as a mediator. It was mixed with glucose oxidase (GOx) and prepared as carbon paste electrode (CPE). Cyclic voltammetry was used for electrochemical measurements. The biosensor showed improved sensitivity when enzyme mediator ratio was 1 : 5, and working pH was 6.6 in 0.1 M phosphate buffer. The linear response of the biosensor for glucose concentration was in the range from 0.5 to 10 mM, with low detection limit of 0.36 mM (calculated as 3 s/n) and sensitivity of 0.16 μA/mM. The reproducibility of the biosensor, calculated as relative standard deviation, was 1.9% for 6 intra-day measurements. Biosensor was stored at +4 °C between experiments, and it was stable during 14 days after the preparation. The developed biosensor was applied on determination of glucose in commercial beverages (apple and cherry juice) and obtained results showed good agreement with the reference method.",
publisher = "Wiley-Blackwell",
journal = "ChemistrySelect",
title = "Application of N,N’-Bis(acetylacetonato)propylenediimine Copper(II) Complex as Mediator for Glucose Biosensor",
volume = "5",
number = "5",
pages = "1671-1675",
doi = "10.1002/slct.201904873"
}
Perušković, D. S., Stevanović, N. R., Kovačević, G., Stanković, D., Lolić, A.,& Baošić, R.. (2020). Application of N,N’-Bis(acetylacetonato)propylenediimine Copper(II) Complex as Mediator for Glucose Biosensor. in ChemistrySelect
Wiley-Blackwell., 5(5), 1671-1675.
https://doi.org/10.1002/slct.201904873
Perušković DS, Stevanović NR, Kovačević G, Stanković D, Lolić A, Baošić R. Application of N,N’-Bis(acetylacetonato)propylenediimine Copper(II) Complex as Mediator for Glucose Biosensor. in ChemistrySelect. 2020;5(5):1671-1675.
doi:10.1002/slct.201904873 .
Perušković, Danica S., Stevanović, Nikola R., Kovačević, Gordana, Stanković, Dalibor, Lolić, Aleksandar, Baošić, Rada, "Application of N,N’-Bis(acetylacetonato)propylenediimine Copper(II) Complex as Mediator for Glucose Biosensor" in ChemistrySelect, 5, no. 5 (2020):1671-1675,
https://doi.org/10.1002/slct.201904873 . .
1
2
2
2

Supplementary material for the article: Elshaflu, H.; Todorović, T. R.; Nikolić, M.; Lolić, A.; Višnjevac, A.; Hagenow, S.; Padrón, J. M.; García-Sosa, A. T.; Djordjevic, I. S.; Grubišic, S.; et al. Selenazolyl-Hydrazones as Novel Selective MAO Inhibitors with Antiproliferative and Antioxidant Activities: Experimental and In-Silico Studies. Frontiers in Chemistry 2018, 6 (JUL). https://doi.org/10.3389/fchem.2018.00247

Elshaflu, Hana; Todorović, Tamara; Nikolić, Milan; Lolić, Aleksandar; Višnjevac, Aleksandar; Hagenow, Stefanie; Padrón, José M.; Garcia-Sosa, Alfonso T.; Đorđević, Ivana S.; Grubišić, Sonja; Stark, Holger; Filipović, Nenad R.

(Frontiers Media Sa, Lausanne, 2018)

TY  - DATA
AU  - Elshaflu, Hana
AU  - Todorović, Tamara
AU  - Nikolić, Milan
AU  - Lolić, Aleksandar
AU  - Višnjevac, Aleksandar
AU  - Hagenow, Stefanie
AU  - Padrón, José M.
AU  - Garcia-Sosa, Alfonso T.
AU  - Đorđević, Ivana S.
AU  - Grubišić, Sonja
AU  - Stark, Holger
AU  - Filipović, Nenad R.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3254
PB  - Frontiers Media Sa, Lausanne
T2  - FRONTIERS IN CHEMISTRY
T1  - Supplementary material for the article: Elshaflu, H.; Todorović, T. R.; Nikolić, M.; Lolić, A.; Višnjevac, A.; Hagenow, S.; Padrón, J. M.; García-Sosa, A. T.; Djordjevic, I. S.; Grubišic, S.; et al. Selenazolyl-Hydrazones as Novel Selective MAO Inhibitors with Antiproliferative and Antioxidant Activities: Experimental and In-Silico Studies. Frontiers in Chemistry 2018, 6 (JUL). https://doi.org/10.3389/fchem.2018.00247
ER  - 
@misc{
author = "Elshaflu, Hana and Todorović, Tamara and Nikolić, Milan and Lolić, Aleksandar and Višnjevac, Aleksandar and Hagenow, Stefanie and Padrón, José M. and Garcia-Sosa, Alfonso T. and Đorđević, Ivana S. and Grubišić, Sonja and Stark, Holger and Filipović, Nenad R.",
year = "2018",
publisher = "Frontiers Media Sa, Lausanne",
journal = "FRONTIERS IN CHEMISTRY",
title = "Supplementary material for the article: Elshaflu, H.; Todorović, T. R.; Nikolić, M.; Lolić, A.; Višnjevac, A.; Hagenow, S.; Padrón, J. M.; García-Sosa, A. T.; Djordjevic, I. S.; Grubišic, S.; et al. Selenazolyl-Hydrazones as Novel Selective MAO Inhibitors with Antiproliferative and Antioxidant Activities: Experimental and In-Silico Studies. Frontiers in Chemistry 2018, 6 (JUL). https://doi.org/10.3389/fchem.2018.00247"
}
Elshaflu, H., Todorović, T., Nikolić, M., Lolić, A., Višnjevac, A., Hagenow, S., Padrón, J. M., Garcia-Sosa, A. T., Đorđević, I. S., Grubišić, S., Stark, H.,& Filipović, N. R.. (2018). Supplementary material for the article: Elshaflu, H.; Todorović, T. R.; Nikolić, M.; Lolić, A.; Višnjevac, A.; Hagenow, S.; Padrón, J. M.; García-Sosa, A. T.; Djordjevic, I. S.; Grubišic, S.; et al. Selenazolyl-Hydrazones as Novel Selective MAO Inhibitors with Antiproliferative and Antioxidant Activities: Experimental and In-Silico Studies. Frontiers in Chemistry 2018, 6 (JUL). https://doi.org/10.3389/fchem.2018.00247. in FRONTIERS IN CHEMISTRY
Frontiers Media Sa, Lausanne..
Elshaflu H, Todorović T, Nikolić M, Lolić A, Višnjevac A, Hagenow S, Padrón JM, Garcia-Sosa AT, Đorđević IS, Grubišić S, Stark H, Filipović NR. Supplementary material for the article: Elshaflu, H.; Todorović, T. R.; Nikolić, M.; Lolić, A.; Višnjevac, A.; Hagenow, S.; Padrón, J. M.; García-Sosa, A. T.; Djordjevic, I. S.; Grubišic, S.; et al. Selenazolyl-Hydrazones as Novel Selective MAO Inhibitors with Antiproliferative and Antioxidant Activities: Experimental and In-Silico Studies. Frontiers in Chemistry 2018, 6 (JUL). https://doi.org/10.3389/fchem.2018.00247. in FRONTIERS IN CHEMISTRY. 2018;..
Elshaflu, Hana, Todorović, Tamara, Nikolić, Milan, Lolić, Aleksandar, Višnjevac, Aleksandar, Hagenow, Stefanie, Padrón, José M., Garcia-Sosa, Alfonso T., Đorđević, Ivana S., Grubišić, Sonja, Stark, Holger, Filipović, Nenad R., "Supplementary material for the article: Elshaflu, H.; Todorović, T. R.; Nikolić, M.; Lolić, A.; Višnjevac, A.; Hagenow, S.; Padrón, J. M.; García-Sosa, A. T.; Djordjevic, I. S.; Grubišic, S.; et al. Selenazolyl-Hydrazones as Novel Selective MAO Inhibitors with Antiproliferative and Antioxidant Activities: Experimental and In-Silico Studies. Frontiers in Chemistry 2018, 6 (JUL). https://doi.org/10.3389/fchem.2018.00247" in FRONTIERS IN CHEMISTRY (2018).

Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies

Elshaflu, Hana; Todorović, Tamara; Nikolić, Milan; Lolić, Aleksandar; Višnjevac, Aleksandar; Hagenow, Stefanie; Padrón, José M.; Garcia-Sosa, Alfonso T.; Đorđević, Ivana S.; Grubišić, Sonja; Stark, Holger; Filipović, Nenad R.

(Frontiers Media Sa, Lausanne, 2018)

TY  - JOUR
AU  - Elshaflu, Hana
AU  - Todorović, Tamara
AU  - Nikolić, Milan
AU  - Lolić, Aleksandar
AU  - Višnjevac, Aleksandar
AU  - Hagenow, Stefanie
AU  - Padrón, José M.
AU  - Garcia-Sosa, Alfonso T.
AU  - Đorđević, Ivana S.
AU  - Grubišić, Sonja
AU  - Stark, Holger
AU  - Filipović, Nenad R.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2172
AB  - The novel approach in the treatment of complex multifactorial diseases, such as neurodegenerative disorders and cancer, requires a development of efficient multi-targeting oriented drugs. Since oxidative stress significantly contributes to the pathogenesis of cancer and neurodegenerative disorders, potential drug candidates should possess good antioxidant properties Due to promising biological activities shown for structurally related (1,3-thiazol-2-yl)hydrazones, a focused library of 12 structurally related benzylidene-based (1,3-selenazol-2-yl)hydrazones was designed as potential multi-targeting compounds. Monoamine oxidases (MAO) A/B inhibition properties of this class of compounds have been investigated. Surprisingly, the p-nitrophenyl-substituted (1,3-selenazol-2-yl)hydrazone 4 showed MAO B inhibition in a nanomolar concentration range (IC50 = 73 nM). Excellent antioxidant properties were confirmed in a number of different in vitro assays. Antiproliferative activity screening on a panel of six human solid tumor cell lines showed that potencies of some of the investigated compounds was comparable or even better than that of the positive control 5-fluorouracil. In-silico calculations of ADME properties pointed to promising good pharmacokinetic profiles of investigated compounds. Docking studies suggest that some compounds, compared to positive controls, have the ability to strongly interact with targets relevant to cancer such as 5'-nucleotidase, and to neurodegenerative diseases such as the small conductance calcium-activated potassium channel protein 1, in addition to confirmation of inhibitory binding at MAO B.
PB  - Frontiers Media Sa, Lausanne
T2  - FRONTIERS IN CHEMISTRY
T1  - Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies
VL  - 6
DO  - 10.3389/fchem.2018.00247
UR  - Kon_3503
ER  - 
@article{
author = "Elshaflu, Hana and Todorović, Tamara and Nikolić, Milan and Lolić, Aleksandar and Višnjevac, Aleksandar and Hagenow, Stefanie and Padrón, José M. and Garcia-Sosa, Alfonso T. and Đorđević, Ivana S. and Grubišić, Sonja and Stark, Holger and Filipović, Nenad R.",
year = "2018",
abstract = "The novel approach in the treatment of complex multifactorial diseases, such as neurodegenerative disorders and cancer, requires a development of efficient multi-targeting oriented drugs. Since oxidative stress significantly contributes to the pathogenesis of cancer and neurodegenerative disorders, potential drug candidates should possess good antioxidant properties Due to promising biological activities shown for structurally related (1,3-thiazol-2-yl)hydrazones, a focused library of 12 structurally related benzylidene-based (1,3-selenazol-2-yl)hydrazones was designed as potential multi-targeting compounds. Monoamine oxidases (MAO) A/B inhibition properties of this class of compounds have been investigated. Surprisingly, the p-nitrophenyl-substituted (1,3-selenazol-2-yl)hydrazone 4 showed MAO B inhibition in a nanomolar concentration range (IC50 = 73 nM). Excellent antioxidant properties were confirmed in a number of different in vitro assays. Antiproliferative activity screening on a panel of six human solid tumor cell lines showed that potencies of some of the investigated compounds was comparable or even better than that of the positive control 5-fluorouracil. In-silico calculations of ADME properties pointed to promising good pharmacokinetic profiles of investigated compounds. Docking studies suggest that some compounds, compared to positive controls, have the ability to strongly interact with targets relevant to cancer such as 5'-nucleotidase, and to neurodegenerative diseases such as the small conductance calcium-activated potassium channel protein 1, in addition to confirmation of inhibitory binding at MAO B.",
publisher = "Frontiers Media Sa, Lausanne",
journal = "FRONTIERS IN CHEMISTRY",
title = "Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies",
volume = "6",
doi = "10.3389/fchem.2018.00247",
url = "Kon_3503"
}
Elshaflu, H., Todorović, T., Nikolić, M., Lolić, A., Višnjevac, A., Hagenow, S., Padrón, J. M., Garcia-Sosa, A. T., Đorđević, I. S., Grubišić, S., Stark, H.,& Filipović, N. R.. (2018). Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies. in FRONTIERS IN CHEMISTRY
Frontiers Media Sa, Lausanne., 6.
https://doi.org/10.3389/fchem.2018.00247
Kon_3503
Elshaflu H, Todorović T, Nikolić M, Lolić A, Višnjevac A, Hagenow S, Padrón JM, Garcia-Sosa AT, Đorđević IS, Grubišić S, Stark H, Filipović NR. Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies. in FRONTIERS IN CHEMISTRY. 2018;6.
doi:10.3389/fchem.2018.00247
Kon_3503 .
Elshaflu, Hana, Todorović, Tamara, Nikolić, Milan, Lolić, Aleksandar, Višnjevac, Aleksandar, Hagenow, Stefanie, Padrón, José M., Garcia-Sosa, Alfonso T., Đorđević, Ivana S., Grubišić, Sonja, Stark, Holger, Filipović, Nenad R., "Selenazolyl-hydrazones as Novel Selective MAO Inhibitors With Antiproliferative and Antioxidant Activities: Experimental and In-silico Studies" in FRONTIERS IN CHEMISTRY, 6 (2018),
https://doi.org/10.3389/fchem.2018.00247 .,
Kon_3503 .
2
15
14
14

Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination

Antunović, Vesna R.; Tešanović, Slavna; Perušković, Danica S.; Stevanović, Nikola R.; Baošić, Rada; Mandić, Snezana D.; Lolić, Aleksandar

(Hindawi Ltd, London, 2018)

TY  - JOUR
AU  - Antunović, Vesna R.
AU  - Tešanović, Slavna
AU  - Perušković, Danica S.
AU  - Stevanović, Nikola R.
AU  - Baošić, Rada
AU  - Mandić, Snezana D.
AU  - Lolić, Aleksandar
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2122
AB  - The is work presents the development of a flow injection system for differential pulse amperometry (DPA) for diazepam determination in the presence of oxygen. The thin flow cell consisted of the bare glassy carbon electrode, reference silver/silver chloride, and stainless steel as the auxiliary electrode. Electrochemical reduction of diazepam (DZP) was characterised by cyclic voltammetry. Azomethine reduction peak was used for DZP quantification. The detector response was linear in the range 20-250 mu mol/dm(3) of diazepam, with a calculated detection limit of 3.83 mu g/cm(3). Intraday and interday precision were 1.53 and 10.8%, respectively. The method was applied on three beverage samples, energetic drink, and two different beer samples, and obtained recoveries were from 93.65 up to 104.96%. The throughoutput of the method was up to 90 analyses per hour.
PB  - Hindawi Ltd, London
T2  - Journal of Analytical Methods in Chemistry
T1  - Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination
DO  - 10.1155/2018/6121489
UR  - Kon_3453
ER  - 
@article{
author = "Antunović, Vesna R. and Tešanović, Slavna and Perušković, Danica S. and Stevanović, Nikola R. and Baošić, Rada and Mandić, Snezana D. and Lolić, Aleksandar",
year = "2018",
abstract = "The is work presents the development of a flow injection system for differential pulse amperometry (DPA) for diazepam determination in the presence of oxygen. The thin flow cell consisted of the bare glassy carbon electrode, reference silver/silver chloride, and stainless steel as the auxiliary electrode. Electrochemical reduction of diazepam (DZP) was characterised by cyclic voltammetry. Azomethine reduction peak was used for DZP quantification. The detector response was linear in the range 20-250 mu mol/dm(3) of diazepam, with a calculated detection limit of 3.83 mu g/cm(3). Intraday and interday precision were 1.53 and 10.8%, respectively. The method was applied on three beverage samples, energetic drink, and two different beer samples, and obtained recoveries were from 93.65 up to 104.96%. The throughoutput of the method was up to 90 analyses per hour.",
publisher = "Hindawi Ltd, London",
journal = "Journal of Analytical Methods in Chemistry",
title = "Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination",
doi = "10.1155/2018/6121489",
url = "Kon_3453"
}
Antunović, V. R., Tešanović, S., Perušković, D. S., Stevanović, N. R., Baošić, R., Mandić, S. D.,& Lolić, A.. (2018). Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination. in Journal of Analytical Methods in Chemistry
Hindawi Ltd, London..
https://doi.org/10.1155/2018/6121489
Kon_3453
Antunović VR, Tešanović S, Perušković DS, Stevanović NR, Baošić R, Mandić SD, Lolić A. Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination. in Journal of Analytical Methods in Chemistry. 2018;.
doi:10.1155/2018/6121489
Kon_3453 .
Antunović, Vesna R., Tešanović, Slavna, Perušković, Danica S., Stevanović, Nikola R., Baošić, Rada, Mandić, Snezana D., Lolić, Aleksandar, "Development of a Flow Injection System for Differential Pulse Amperometry and Its Application for Diazepam Determination" in Journal of Analytical Methods in Chemistry (2018),
https://doi.org/10.1155/2018/6121489 .,
Kon_3453 .
4
3

Klasične metode kvantitativne hemijske analize

Baošić, Rada; Lolić, Aleksandar; Mutić, Jelena; Stevanović, Nikola R.

(Hemijski fakultet, 2018)

TY  - BOOK
AU  - Baošić, Rada
AU  - Lolić, Aleksandar
AU  - Mutić, Jelena
AU  - Stevanović, Nikola R.
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2888
PB  - Hemijski fakultet
T1  - Klasične metode kvantitativne hemijske analize
ER  - 
@book{
author = "Baošić, Rada and Lolić, Aleksandar and Mutić, Jelena and Stevanović, Nikola R.",
year = "2018",
publisher = "Hemijski fakultet",
title = "Klasične metode kvantitativne hemijske analize"
}
Baošić, R., Lolić, A., Mutić, J.,& Stevanović, N. R.. (2018). Klasične metode kvantitativne hemijske analize. 
Hemijski fakultet..
Baošić R, Lolić A, Mutić J, Stevanović NR. Klasične metode kvantitativne hemijske analize. 2018;..
Baošić, Rada, Lolić, Aleksandar, Mutić, Jelena, Stevanović, Nikola R., "Klasične metode kvantitativne hemijske analize" (2018).

Synthesis and Characterization of MnCo2O4 Porous Spinel Oxide

Antunović, Vesna R.; Jelić, Dijana; Nedić, Zoran; Ilić, Marija D.; Lolić, Aleksandar

(Belgrade : Serbian Academy of Sciences and Arts, 2018)

TY  - CONF
AU  - Antunović, Vesna R.
AU  - Jelić, Dijana
AU  - Nedić, Zoran
AU  - Ilić, Marija D.
AU  - Lolić, Aleksandar
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2791
AB  - This work presents an investigation on spinel structured material that consist of Mn(II) and Co(II) combined in the formula MnCo2O4, where Mn(II) occupies tetrahedral and Co(II) octahedral sites of crystal structure. Such spinel structured material, MnCo2O4 was synthesized by citrate-gel combustion (CGC) technique, carefully chosen as the method of synthesis is very important for producing a material
with desirable physico-chemical characteristics.
PB  - Belgrade : Serbian Academy of Sciences and Arts
C3  - Program and Book of Abstracts / First International Conference on Electron Microscopy of Nanostructures ELMINA 2018, August 27-29, 2018, Belgrade, Serbia
T1  - Synthesis and Characterization of MnCo2O4 Porous Spinel Oxide
SP  - 216
EP  - 218
ER  - 
@conference{
author = "Antunović, Vesna R. and Jelić, Dijana and Nedić, Zoran and Ilić, Marija D. and Lolić, Aleksandar",
year = "2018",
abstract = "This work presents an investigation on spinel structured material that consist of Mn(II) and Co(II) combined in the formula MnCo2O4, where Mn(II) occupies tetrahedral and Co(II) octahedral sites of crystal structure. Such spinel structured material, MnCo2O4 was synthesized by citrate-gel combustion (CGC) technique, carefully chosen as the method of synthesis is very important for producing a material
with desirable physico-chemical characteristics.",
publisher = "Belgrade : Serbian Academy of Sciences and Arts",
journal = "Program and Book of Abstracts / First International Conference on Electron Microscopy of Nanostructures ELMINA 2018, August 27-29, 2018, Belgrade, Serbia",
title = "Synthesis and Characterization of MnCo2O4 Porous Spinel Oxide",
pages = "216-218"
}
Antunović, V. R., Jelić, D., Nedić, Z., Ilić, M. D.,& Lolić, A.. (2018). Synthesis and Characterization of MnCo2O4 Porous Spinel Oxide. in Program and Book of Abstracts / First International Conference on Electron Microscopy of Nanostructures ELMINA 2018, August 27-29, 2018, Belgrade, Serbia
Belgrade : Serbian Academy of Sciences and Arts., 216-218.
Antunović VR, Jelić D, Nedić Z, Ilić MD, Lolić A. Synthesis and Characterization of MnCo2O4 Porous Spinel Oxide. in Program and Book of Abstracts / First International Conference on Electron Microscopy of Nanostructures ELMINA 2018, August 27-29, 2018, Belgrade, Serbia. 2018;:216-218..
Antunović, Vesna R., Jelić, Dijana, Nedić, Zoran, Ilić, Marija D., Lolić, Aleksandar, "Synthesis and Characterization of MnCo2O4 Porous Spinel Oxide" in Program and Book of Abstracts / First International Conference on Electron Microscopy of Nanostructures ELMINA 2018, August 27-29, 2018, Belgrade, Serbia (2018):216-218.

Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study

Đorđević, Ivana S.; Vukašinović, Jelena; Todorović, Tamara; Filipović, Nenad R.; Rodić, Marko; Lolić, Aleksandar; Portalone, Gustavo; Zlatović, Mario; Grubišić, Sonja

(Serbian Chemical Soc, Belgrade, 2017)

TY  - JOUR
AU  - Đorđević, Ivana S.
AU  - Vukašinović, Jelena
AU  - Todorović, Tamara
AU  - Filipović, Nenad R.
AU  - Rodić, Marko
AU  - Lolić, Aleksandar
AU  - Portalone, Gustavo
AU  - Zlatović, Mario
AU  - Grubišić, Sonja
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2520
AB  - Cobalt(III) complexes derived from thio-and selenosemicarbazone ligands have been studied to elucidate the nature and consequences of S to Se substitution on their possible biological activity. Solid state structures of cobalt(III) complexes with bis-tridentate coordinated 2-quinolinecarboxaldehyde thio-and selenosemicarbazone were determined by single crystal X-ray diffraction analysis. The complexes were also characterized by spectroscopic methods and cyclic voltammetry. Electronic properties of the complexes were studied using DFT and TD-DFT methods. Finally, evident in vitro antioxidant activity of the complexes was demonstrated.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study
VL  - 82
IS  - 7-8
SP  - 825
EP  - 839
DO  - 10.2298/JSC170412062D
UR  - Kon_3336
ER  - 
@article{
author = "Đorđević, Ivana S. and Vukašinović, Jelena and Todorović, Tamara and Filipović, Nenad R. and Rodić, Marko and Lolić, Aleksandar and Portalone, Gustavo and Zlatović, Mario and Grubišić, Sonja",
year = "2017",
abstract = "Cobalt(III) complexes derived from thio-and selenosemicarbazone ligands have been studied to elucidate the nature and consequences of S to Se substitution on their possible biological activity. Solid state structures of cobalt(III) complexes with bis-tridentate coordinated 2-quinolinecarboxaldehyde thio-and selenosemicarbazone were determined by single crystal X-ray diffraction analysis. The complexes were also characterized by spectroscopic methods and cyclic voltammetry. Electronic properties of the complexes were studied using DFT and TD-DFT methods. Finally, evident in vitro antioxidant activity of the complexes was demonstrated.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study",
volume = "82",
number = "7-8",
pages = "825-839",
doi = "10.2298/JSC170412062D",
url = "Kon_3336"
}
Đorđević, I. S., Vukašinović, J., Todorović, T., Filipović, N. R., Rodić, M., Lolić, A., Portalone, G., Zlatović, M.,& Grubišić, S.. (2017). Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 82(7-8), 825-839.
https://doi.org/10.2298/JSC170412062D
Kon_3336
Đorđević IS, Vukašinović J, Todorović T, Filipović NR, Rodić M, Lolić A, Portalone G, Zlatović M, Grubišić S. Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study. in Journal of the Serbian Chemical Society. 2017;82(7-8):825-839.
doi:10.2298/JSC170412062D
Kon_3336 .
Đorđević, Ivana S., Vukašinović, Jelena, Todorović, Tamara, Filipović, Nenad R., Rodić, Marko, Lolić, Aleksandar, Portalone, Gustavo, Zlatović, Mario, Grubišić, Sonja, "Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study" in Journal of the Serbian Chemical Society, 82, no. 7-8 (2017):825-839,
https://doi.org/10.2298/JSC170412062D .,
Kon_3336 .
5
4
5

Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes

Stevanović, Nikola R.; Perušković, Danica S.; Gašić, Uroš M.; Antunović, Vesna R.; Lolić, Aleksandar; Baošić, Rada

(Wiley, Hoboken, 2017)

TY  - JOUR
AU  - Stevanović, Nikola R.
AU  - Perušković, Danica S.
AU  - Gašić, Uroš M.
AU  - Antunović, Vesna R.
AU  - Lolić, Aleksandar
AU  - Baošić, Rada
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2443
AB  - The objectives of this study were to gain insights into structure-retention relationships and to propose the model to estimating their retention. Chromatographic investigation of series of 36 Schiff bases and their copper(II) and nickel(II) complexes was performed under both normaland reverse-phase conditions. Chemical structures of the compounds were characterized by molecular descriptors which are calculated from the structure and related to the chromatographic retention parameters by multiple linear regression analysis. Effects of chelation on retention parameters of investigated compounds, under normal-and reverse-phase chromatographic conditions, were analyzed by principal component analysis, quantitative structure-retention relationship and quantitative structure-activity relationship models were developed on the basis of theoretical molecular descriptors, calculated exclusively from molecular structure, and parameters of retention and lipophilicity.
PB  - Wiley, Hoboken
T2  - Biomedical Chromatography
T1  - Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes
VL  - 31
IS  - 3
DO  - 10.1002/bmc.3810
UR  - Kon_3259
ER  - 
@article{
author = "Stevanović, Nikola R. and Perušković, Danica S. and Gašić, Uroš M. and Antunović, Vesna R. and Lolić, Aleksandar and Baošić, Rada",
year = "2017",
abstract = "The objectives of this study were to gain insights into structure-retention relationships and to propose the model to estimating their retention. Chromatographic investigation of series of 36 Schiff bases and their copper(II) and nickel(II) complexes was performed under both normaland reverse-phase conditions. Chemical structures of the compounds were characterized by molecular descriptors which are calculated from the structure and related to the chromatographic retention parameters by multiple linear regression analysis. Effects of chelation on retention parameters of investigated compounds, under normal-and reverse-phase chromatographic conditions, were analyzed by principal component analysis, quantitative structure-retention relationship and quantitative structure-activity relationship models were developed on the basis of theoretical molecular descriptors, calculated exclusively from molecular structure, and parameters of retention and lipophilicity.",
publisher = "Wiley, Hoboken",
journal = "Biomedical Chromatography",
title = "Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes",
volume = "31",
number = "3",
doi = "10.1002/bmc.3810",
url = "Kon_3259"
}
Stevanović, N. R., Perušković, D. S., Gašić, U. M., Antunović, V. R., Lolić, A.,& Baošić, R.. (2017). Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes. in Biomedical Chromatography
Wiley, Hoboken., 31(3).
https://doi.org/10.1002/bmc.3810
Kon_3259
Stevanović NR, Perušković DS, Gašić UM, Antunović VR, Lolić A, Baošić R. Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes. in Biomedical Chromatography. 2017;31(3).
doi:10.1002/bmc.3810
Kon_3259 .
Stevanović, Nikola R., Perušković, Danica S., Gašić, Uroš M., Antunović, Vesna R., Lolić, Aleksandar, Baošić, Rada, "Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes" in Biomedical Chromatography, 31, no. 3 (2017),
https://doi.org/10.1002/bmc.3810 .,
Kon_3259 .
1
2
2
2

Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes

Perušković, Danica S.; Gašić, Uroš M.; Antunović, Vesna R.; Lolić, Aleksandar; Baošić, Rada; Stevanović, Nikola R.

(Wiley, Hoboken, 2017)

TY  - JOUR
AU  - Perušković, Danica S.
AU  - Gašić, Uroš M.
AU  - Antunović, Vesna R.
AU  - Lolić, Aleksandar
AU  - Baošić, Rada
AU  - Stevanović, Nikola R.
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2982
AB  - The objectives of this study were to gain insights into structure-retention relationships and to propose the model to estimating their retention. Chromatographic investigation of series of 36 Schiff bases and their copper(II) and nickel(II) complexes was performed under both normaland reverse-phase conditions. Chemical structures of the compounds were characterized by molecular descriptors which are calculated from the structure and related to the chromatographic retention parameters by multiple linear regression analysis. Effects of chelation on retention parameters of investigated compounds, under normal-and reverse-phase chromatographic conditions, were analyzed by principal component analysis, quantitative structure-retention relationship and quantitative structure-activity relationship models were developed on the basis of theoretical molecular descriptors, calculated exclusively from molecular structure, and parameters of retention and lipophilicity.
PB  - Wiley, Hoboken
T2  - Biomedical Chromatography
T1  - Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes
VL  - 31
IS  - 3
DO  - 10.1002/bmc.3810
ER  - 
@article{
author = "Perušković, Danica S. and Gašić, Uroš M. and Antunović, Vesna R. and Lolić, Aleksandar and Baošić, Rada and Stevanović, Nikola R.",
year = "2017",
abstract = "The objectives of this study were to gain insights into structure-retention relationships and to propose the model to estimating their retention. Chromatographic investigation of series of 36 Schiff bases and their copper(II) and nickel(II) complexes was performed under both normaland reverse-phase conditions. Chemical structures of the compounds were characterized by molecular descriptors which are calculated from the structure and related to the chromatographic retention parameters by multiple linear regression analysis. Effects of chelation on retention parameters of investigated compounds, under normal-and reverse-phase chromatographic conditions, were analyzed by principal component analysis, quantitative structure-retention relationship and quantitative structure-activity relationship models were developed on the basis of theoretical molecular descriptors, calculated exclusively from molecular structure, and parameters of retention and lipophilicity.",
publisher = "Wiley, Hoboken",
journal = "Biomedical Chromatography",
title = "Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes",
volume = "31",
number = "3",
doi = "10.1002/bmc.3810"
}
Perušković, D. S., Gašić, U. M., Antunović, V. R., Lolić, A., Baošić, R.,& Stevanović, N. R.. (2017). Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes. in Biomedical Chromatography
Wiley, Hoboken., 31(3).
https://doi.org/10.1002/bmc.3810
Perušković DS, Gašić UM, Antunović VR, Lolić A, Baošić R, Stevanović NR. Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes. in Biomedical Chromatography. 2017;31(3).
doi:10.1002/bmc.3810 .
Perušković, Danica S., Gašić, Uroš M., Antunović, Vesna R., Lolić, Aleksandar, Baošić, Rada, Stevanović, Nikola R., "Effect of substituents on prediction of TLC retention of tetradentate Schiff bases and their Copper(II) and Nickel(II) complexes" in Biomedical Chromatography, 31, no. 3 (2017),
https://doi.org/10.1002/bmc.3810 . .
1
2
2
2

The Influence of Alkyl Polyglucosides (And Highly Ethoxylated Alcohol Boosters) on the Phase Behavior of a Water/Toluene/Technical Alkyl Polyethoxylate Microemulsion System

Ilić, Marija; Haegel, Franz-Hubert; Pavelkić, Vesna; Zlatanović, Dragan; Nikolić-Mandić, Snežana D.; Lolić, Aleksandar; Nedić, Zoran

(Assoc Chemical Eng, Belgrade, 2016)

TY  - JOUR
AU  - Ilić, Marija
AU  - Haegel, Franz-Hubert
AU  - Pavelkić, Vesna
AU  - Zlatanović, Dragan
AU  - Nikolić-Mandić, Snežana D.
AU  - Lolić, Aleksandar
AU  - Nedić, Zoran
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1916
AB  - The influence of additives (alkyl polyglucoside, Glucopon 600 CS UP and alcohol ethoxylate C18E100) on the behavior of the water/toluene/Lutensol ON 50 (technical oxoalcohol, i-C10E5) microemulsion system as a function of temperature and composition has been investigated. The phase behavior of the microemulsions was determined by vertical sections through the Gibbs phase prism (fish-like phase diagrams). Alkyl polyglucoside shifts the one phase region to lower temperatures compared with water/toluene/Lutensol ON 50 mixtures. This is contrary to the expectation, considering the extreme hydrophilic nature of the sugar headgroup. The addition of hydrophilic alcohol ethoxylate (C18E100) to the water/toluene/Lutensol ON 50 system increases the solubilization capacity of the surfactant, even if the co-surfactant is used in small quantities, and shifts the one-phase region to higher temperature by a few degrees C.
PB  - Assoc Chemical Eng, Belgrade
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - The Influence of Alkyl Polyglucosides (And Highly Ethoxylated Alcohol Boosters) on the Phase Behavior of a Water/Toluene/Technical Alkyl Polyethoxylate Microemulsion System
VL  - 22
IS  - 1
SP  - 27
EP  - 32
DO  - 10.2298/CICEQ141105015I
UR  - Kon_3035
ER  - 
@article{
author = "Ilić, Marija and Haegel, Franz-Hubert and Pavelkić, Vesna and Zlatanović, Dragan and Nikolić-Mandić, Snežana D. and Lolić, Aleksandar and Nedić, Zoran",
year = "2016",
abstract = "The influence of additives (alkyl polyglucoside, Glucopon 600 CS UP and alcohol ethoxylate C18E100) on the behavior of the water/toluene/Lutensol ON 50 (technical oxoalcohol, i-C10E5) microemulsion system as a function of temperature and composition has been investigated. The phase behavior of the microemulsions was determined by vertical sections through the Gibbs phase prism (fish-like phase diagrams). Alkyl polyglucoside shifts the one phase region to lower temperatures compared with water/toluene/Lutensol ON 50 mixtures. This is contrary to the expectation, considering the extreme hydrophilic nature of the sugar headgroup. The addition of hydrophilic alcohol ethoxylate (C18E100) to the water/toluene/Lutensol ON 50 system increases the solubilization capacity of the surfactant, even if the co-surfactant is used in small quantities, and shifts the one-phase region to higher temperature by a few degrees C.",
publisher = "Assoc Chemical Eng, Belgrade",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "The Influence of Alkyl Polyglucosides (And Highly Ethoxylated Alcohol Boosters) on the Phase Behavior of a Water/Toluene/Technical Alkyl Polyethoxylate Microemulsion System",
volume = "22",
number = "1",
pages = "27-32",
doi = "10.2298/CICEQ141105015I",
url = "Kon_3035"
}
Ilić, M., Haegel, F., Pavelkić, V., Zlatanović, D., Nikolić-Mandić, S. D., Lolić, A.,& Nedić, Z.. (2016). The Influence of Alkyl Polyglucosides (And Highly Ethoxylated Alcohol Boosters) on the Phase Behavior of a Water/Toluene/Technical Alkyl Polyethoxylate Microemulsion System. in Chemical Industry and Chemical Engineering Quarterly / CICEQ
Assoc Chemical Eng, Belgrade., 22(1), 27-32.
https://doi.org/10.2298/CICEQ141105015I
Kon_3035
Ilić M, Haegel F, Pavelkić V, Zlatanović D, Nikolić-Mandić SD, Lolić A, Nedić Z. The Influence of Alkyl Polyglucosides (And Highly Ethoxylated Alcohol Boosters) on the Phase Behavior of a Water/Toluene/Technical Alkyl Polyethoxylate Microemulsion System. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2016;22(1):27-32.
doi:10.2298/CICEQ141105015I
Kon_3035 .
Ilić, Marija, Haegel, Franz-Hubert, Pavelkić, Vesna, Zlatanović, Dragan, Nikolić-Mandić, Snežana D., Lolić, Aleksandar, Nedić, Zoran, "The Influence of Alkyl Polyglucosides (And Highly Ethoxylated Alcohol Boosters) on the Phase Behavior of a Water/Toluene/Technical Alkyl Polyethoxylate Microemulsion System" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 22, no. 1 (2016):27-32,
https://doi.org/10.2298/CICEQ141105015I .,
Kon_3035 .
1
1
1

Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases

Perušković, Danica S.; Daric, Branka; Blagus, Anita; Stevanović, Nikola R.; Pavlović, Aleksandra V.; Lolić, Aleksandar; Baošić, Rada

(Springer Wien, Wien, 2015)

TY  - JOUR
AU  - Perušković, Danica S.
AU  - Daric, Branka
AU  - Blagus, Anita
AU  - Stevanović, Nikola R.
AU  - Pavlović, Aleksandra V.
AU  - Lolić, Aleksandar
AU  - Baošić, Rada
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1894
AB  - The lipophilic character of polydentate Schiff bases was investigated by reversed-phase thin-layer chromatography. In order to determine retention parameter as a measure of the lipophilicity of the tested compounds, three different binary solvent systems, composed of water and organic modifier (methanol, acetonitrile, and tetrahydrofuran), were used. Lipophilicity parameters together with 2D molecular descriptors were subjected to the multivariate statistical analysis. Principal component analysis was employed to reveal the most influential factors governing the lipophilicity of the investigated compounds. Finally, the influence of organic modifier on determination of lipophilicity parameters was discussed.
PB  - Springer Wien, Wien
T2  - Monatshefte Fur Chemie
T1  - Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases
VL  - 146
IS  - 1
SP  - 1
EP  - 6
DO  - 10.1007/s00706-014-1313-7
UR  - Kon_2777
ER  - 
@article{
author = "Perušković, Danica S. and Daric, Branka and Blagus, Anita and Stevanović, Nikola R. and Pavlović, Aleksandra V. and Lolić, Aleksandar and Baošić, Rada",
year = "2015",
abstract = "The lipophilic character of polydentate Schiff bases was investigated by reversed-phase thin-layer chromatography. In order to determine retention parameter as a measure of the lipophilicity of the tested compounds, three different binary solvent systems, composed of water and organic modifier (methanol, acetonitrile, and tetrahydrofuran), were used. Lipophilicity parameters together with 2D molecular descriptors were subjected to the multivariate statistical analysis. Principal component analysis was employed to reveal the most influential factors governing the lipophilicity of the investigated compounds. Finally, the influence of organic modifier on determination of lipophilicity parameters was discussed.",
publisher = "Springer Wien, Wien",
journal = "Monatshefte Fur Chemie",
title = "Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases",
volume = "146",
number = "1",
pages = "1-6",
doi = "10.1007/s00706-014-1313-7",
url = "Kon_2777"
}
Perušković, D. S., Daric, B., Blagus, A., Stevanović, N. R., Pavlović, A. V., Lolić, A.,& Baošić, R.. (2015). Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases. in Monatshefte Fur Chemie
Springer Wien, Wien., 146(1), 1-6.
https://doi.org/10.1007/s00706-014-1313-7
Kon_2777
Perušković DS, Daric B, Blagus A, Stevanović NR, Pavlović AV, Lolić A, Baošić R. Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases. in Monatshefte Fur Chemie. 2015;146(1):1-6.
doi:10.1007/s00706-014-1313-7
Kon_2777 .
Perušković, Danica S., Daric, Branka, Blagus, Anita, Stevanović, Nikola R., Pavlović, Aleksandra V., Lolić, Aleksandar, Baošić, Rada, "Influence of organic modifiers on RP-TLC determination of lipophilicity of some polydentate Schiff bases" in Monatshefte Fur Chemie, 146, no. 1 (2015):1-6,
https://doi.org/10.1007/s00706-014-1313-7 .,
Kon_2777 .
3
4
3

Electrospray ionization linear trap quadrupole Orbitrap in analysis of old tempera paintings: application to nineteenth-century Orthodox icons

Tripković, T.; Charvy, C.; Alves, S.; Lolić, Aleksandar; Baošić, Rada; Nikolić-Mandić, Snežana D.; Tabet, J. C.

(Im Publications, W Sussex, 2015)

TY  - JOUR
AU  - Tripković, T.
AU  - Charvy, C.
AU  - Alves, S.
AU  - Lolić, Aleksandar
AU  - Baošić, Rada
AU  - Nikolić-Mandić, Snežana D.
AU  - Tabet, J. C.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1959
AB  - Proteomic approach in combination with mass spectrometry demonstrates a great potential for identification of proteinaceous materials in works of art. In this study we used a linear trap quadrupole Orbitrap (LTQ-Orbitraph a state-of-the-art mass spectrometer for parts per million accuracy analyses of peptides behind tryptic hydrolysis. After the efficiency of the proteomic method was confirmed for reference and model samples, micro-samples from historical paintings were for the first time analysed using this technique. Superior performances of the liquid chromatography-mass spectrometry approach using a LTQ-Orbitrap mass spectrometer allowed identification of egg yolk peptides in two samples from nineteenth-century Orthodox icons, indicating egg tempera as the painting technique. Accurate precursor ion masses, in the range of 2 ppm, and retention times of tryptic peptides strengthen protein identification. Additionally, in all historical samples the presence of animal glues suggested that the ground layer was likely bound using bovine collagen. Comparing to results acquired using matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry in our previous study, here we achieved higher ion scores and protein scores, better sequence coverage and more identified proteins. In fact, a combination of the two mass spectrometric techniques provided overlapping and complementary data, related to the detection of peptides with different physicochemical properties.
PB  - Im Publications, W Sussex
T2  - European Journal of Mass Spectrometry
T1  - Electrospray ionization linear trap quadrupole Orbitrap in analysis of old tempera paintings: application to nineteenth-century Orthodox icons
VL  - 21
IS  - 4
SP  - 679
EP  - 692
DO  - 10.1255/ejms.1346
UR  - Kon_2914
ER  - 
@article{
author = "Tripković, T. and Charvy, C. and Alves, S. and Lolić, Aleksandar and Baošić, Rada and Nikolić-Mandić, Snežana D. and Tabet, J. C.",
year = "2015",
abstract = "Proteomic approach in combination with mass spectrometry demonstrates a great potential for identification of proteinaceous materials in works of art. In this study we used a linear trap quadrupole Orbitrap (LTQ-Orbitraph a state-of-the-art mass spectrometer for parts per million accuracy analyses of peptides behind tryptic hydrolysis. After the efficiency of the proteomic method was confirmed for reference and model samples, micro-samples from historical paintings were for the first time analysed using this technique. Superior performances of the liquid chromatography-mass spectrometry approach using a LTQ-Orbitrap mass spectrometer allowed identification of egg yolk peptides in two samples from nineteenth-century Orthodox icons, indicating egg tempera as the painting technique. Accurate precursor ion masses, in the range of 2 ppm, and retention times of tryptic peptides strengthen protein identification. Additionally, in all historical samples the presence of animal glues suggested that the ground layer was likely bound using bovine collagen. Comparing to results acquired using matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry in our previous study, here we achieved higher ion scores and protein scores, better sequence coverage and more identified proteins. In fact, a combination of the two mass spectrometric techniques provided overlapping and complementary data, related to the detection of peptides with different physicochemical properties.",
publisher = "Im Publications, W Sussex",
journal = "European Journal of Mass Spectrometry",
title = "Electrospray ionization linear trap quadrupole Orbitrap in analysis of old tempera paintings: application to nineteenth-century Orthodox icons",
volume = "21",
number = "4",
pages = "679-692",
doi = "10.1255/ejms.1346",
url = "Kon_2914"
}
Tripković, T., Charvy, C., Alves, S., Lolić, A., Baošić, R., Nikolić-Mandić, S. D.,& Tabet, J. C.. (2015). Electrospray ionization linear trap quadrupole Orbitrap in analysis of old tempera paintings: application to nineteenth-century Orthodox icons. in European Journal of Mass Spectrometry
Im Publications, W Sussex., 21(4), 679-692.
https://doi.org/10.1255/ejms.1346
Kon_2914
Tripković T, Charvy C, Alves S, Lolić A, Baošić R, Nikolić-Mandić SD, Tabet JC. Electrospray ionization linear trap quadrupole Orbitrap in analysis of old tempera paintings: application to nineteenth-century Orthodox icons. in European Journal of Mass Spectrometry. 2015;21(4):679-692.
doi:10.1255/ejms.1346
Kon_2914 .
Tripković, T., Charvy, C., Alves, S., Lolić, Aleksandar, Baošić, Rada, Nikolić-Mandić, Snežana D., Tabet, J. C., "Electrospray ionization linear trap quadrupole Orbitrap in analysis of old tempera paintings: application to nineteenth-century Orthodox icons" in European Journal of Mass Spectrometry, 21, no. 4 (2015):679-692,
https://doi.org/10.1255/ejms.1346 .,
Kon_2914 .
6
5
5

Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk

Lolić, Aleksandar; Paiga, Paula; Santos, Lucia H. M. L. M.; Ramos, Sandra; Correia, Manuela; Delerue-Matos, Cristina

(Elsevier Science Bv, Amsterdam, 2015)

TY  - JOUR
AU  - Lolić, Aleksandar
AU  - Paiga, Paula
AU  - Santos, Lucia H. M. L. M.
AU  - Ramos, Sandra
AU  - Correia, Manuela
AU  - Delerue-Matos, Cristina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1653
AB  - The occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples covering fourteen beaches and five cities were evaluated in order to assess the spatial distribution of pharmaceuticals among north Portuguese coast. Seawaters were selected in order to embrace different bathing water quality (excellent, good and sufficient). Acetaminophen, ketoprofen and the metabolite hydroxyibuprofen were detected in all the seawater samples at maximum concentrations of 584, 89.7 and 287 ng L-1, respectively. Carboxyibuprofen had the highest seawater concentration (1227 ng L-1). The temporal distribution of the selected pharmaceuticals during the bathing season showed that, in general, higher concentrations were detected in August and September. The environmental risk posed by the pharmaceuticals detected in seawaters towards different trophic levels (fish, daphnids and algae) was also assessed. Only diclofenac showed hazard quotients above one for fish, representing a potential risk for aquatic organisms. These results were observed in seawaters classified as excellent bathing water. Additional data is needed in order to support the identification and prioritization of risks posed by pharmaceuticals in marine environment.
PB  - Elsevier Science Bv, Amsterdam
T2  - Science of the Total Environment
T1  - Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk
VL  - 508
SP  - 240
EP  - 250
DO  - 10.1016/j.scitotenv.2014.11.097
UR  - Kon_2799
ER  - 
@article{
author = "Lolić, Aleksandar and Paiga, Paula and Santos, Lucia H. M. L. M. and Ramos, Sandra and Correia, Manuela and Delerue-Matos, Cristina",
year = "2015",
abstract = "The occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples covering fourteen beaches and five cities were evaluated in order to assess the spatial distribution of pharmaceuticals among north Portuguese coast. Seawaters were selected in order to embrace different bathing water quality (excellent, good and sufficient). Acetaminophen, ketoprofen and the metabolite hydroxyibuprofen were detected in all the seawater samples at maximum concentrations of 584, 89.7 and 287 ng L-1, respectively. Carboxyibuprofen had the highest seawater concentration (1227 ng L-1). The temporal distribution of the selected pharmaceuticals during the bathing season showed that, in general, higher concentrations were detected in August and September. The environmental risk posed by the pharmaceuticals detected in seawaters towards different trophic levels (fish, daphnids and algae) was also assessed. Only diclofenac showed hazard quotients above one for fish, representing a potential risk for aquatic organisms. These results were observed in seawaters classified as excellent bathing water. Additional data is needed in order to support the identification and prioritization of risks posed by pharmaceuticals in marine environment.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Science of the Total Environment",
title = "Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk",
volume = "508",
pages = "240-250",
doi = "10.1016/j.scitotenv.2014.11.097",
url = "Kon_2799"
}
Lolić, A., Paiga, P., Santos, L. H. M. L. M., Ramos, S., Correia, M.,& Delerue-Matos, C.. (2015). Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk. in Science of the Total Environment
Elsevier Science Bv, Amsterdam., 508, 240-250.
https://doi.org/10.1016/j.scitotenv.2014.11.097
Kon_2799
Lolić A, Paiga P, Santos LHMLM, Ramos S, Correia M, Delerue-Matos C. Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk. in Science of the Total Environment. 2015;508:240-250.
doi:10.1016/j.scitotenv.2014.11.097
Kon_2799 .
Lolić, Aleksandar, Paiga, Paula, Santos, Lucia H. M. L. M., Ramos, Sandra, Correia, Manuela, Delerue-Matos, Cristina, "Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk" in Science of the Total Environment, 508 (2015):240-250,
https://doi.org/10.1016/j.scitotenv.2014.11.097 .,
Kon_2799 .
9
133
111
122

Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater

Paiga, Paula; Lolić, Aleksandar; Hellebuyck, Floris; Santos, Lucia H. M. L. M.; Correia, Manuela; Delerue-Matos, Cristina

(Elsevier Science Bv, Amsterdam, 2015)

TY  - JOUR
AU  - Paiga, Paula
AU  - Lolić, Aleksandar
AU  - Hellebuyck, Floris
AU  - Santos, Lucia H. M. L. M.
AU  - Correia, Manuela
AU  - Delerue-Matos, Cristina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1674
AB  - An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE-UHPLC-MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater
VL  - 106
SP  - 61
EP  - 70
DO  - 10.1016/j.jpba.2014.06.017
UR  - Kon_2820
ER  - 
@article{
author = "Paiga, Paula and Lolić, Aleksandar and Hellebuyck, Floris and Santos, Lucia H. M. L. M. and Correia, Manuela and Delerue-Matos, Cristina",
year = "2015",
abstract = "An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE-UHPLC-MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater",
volume = "106",
pages = "61-70",
doi = "10.1016/j.jpba.2014.06.017",
url = "Kon_2820"
}
Paiga, P., Lolić, A., Hellebuyck, F., Santos, L. H. M. L. M., Correia, M.,& Delerue-Matos, C.. (2015). Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science Bv, Amsterdam., 106, 61-70.
https://doi.org/10.1016/j.jpba.2014.06.017
Kon_2820
Paiga P, Lolić A, Hellebuyck F, Santos LHMLM, Correia M, Delerue-Matos C. Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. in Journal of Pharmaceutical and Biomedical Analysis. 2015;106:61-70.
doi:10.1016/j.jpba.2014.06.017
Kon_2820 .
Paiga, Paula, Lolić, Aleksandar, Hellebuyck, Floris, Santos, Lucia H. M. L. M., Correia, Manuela, Delerue-Matos, Cristina, "Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater" in Journal of Pharmaceutical and Biomedical Analysis, 106 (2015):61-70,
https://doi.org/10.1016/j.jpba.2014.06.017 .,
Kon_2820 .
80
81
82

Anthelmintic Activity In Vivo of Epiisopiloturine against Juvenile and Adult Worms of Schistosoma mansoni

Guimaraes, Maria A.; de Oliveira, Rosimeire N.; Veras, Leiz M. C.; Lima, David F.; Campelo, Yuri D. M.; Campos, Stefano Augusto; Kuckelhaus, Selma A. S.; Pinto, Pedro L. S.; Eaton, Peter; Mafud, Ana C.; Mascarenhas, Yvonne P.; Allegretti, Silmara M.; de Moraes, Josue; Lolić, Aleksandar; Verbić, Tatjana; Leite, Jose Roberto S. A.

(Public Library Science, San Francisco, 2015)

TY  - JOUR
AU  - Guimaraes, Maria A.
AU  - de Oliveira, Rosimeire N.
AU  - Veras, Leiz M. C.
AU  - Lima, David F.
AU  - Campelo, Yuri D. M.
AU  - Campos, Stefano Augusto
AU  - Kuckelhaus, Selma A. S.
AU  - Pinto, Pedro L. S.
AU  - Eaton, Peter
AU  - Mafud, Ana C.
AU  - Mascarenhas, Yvonne P.
AU  - Allegretti, Silmara M.
AU  - de Moraes, Josue
AU  - Lolić, Aleksandar
AU  - Verbić, Tatjana
AU  - Leite, Jose Roberto S. A.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1688
AB  - Schistosomiasis is a serious disease currently estimated to affect more that 207 million people worldwide. Due to the intensive use of praziquantel, there is increasing concern about the development of drug-resistant strains. Therefore, it is necessary to search for and investigate new potential schistosomicidal compounds. This work reports the in vivo effect of the alkaloid epiisopiloturine (EPI) against adults and juvenile worms of Schistosoma mansoni. EPI was first purified its thermal behavior and theoretical solubility parameters charaterised. In the experiment, mice were treated with EPI over the 21 days post-infection with the doses of 40 and 200 mg/kg, and 45 days post-infection with single doses of 40, 100 and 300 mg/kg. The treatment with EPI at 40 mg/kg was more effective in adult worms when compared with doses of 100 and 300 mg/kg. The treatment with 40 mg/kg in adult worms reduced parasite burden significantly, lead to reduction in hepatosplenomegaly, reduced the egg burden in faeces, and decreased granuloma diameter. Scanning electron microscopy revealed morphological changes to the parasite tegument after treatment, including the loss of important features. Additionally, the in vivo treatment against juvenile with 40 mg/kg showed a reduction of the total worm burden of 50.2%. Histopathological studies were performed on liver, spleen, lung, kidney and brain and EPI was shown to have a DL50 of 8000 mg/kg. Therefore EPI shows potential to be used in schistosomiasis treatment. This is the first time that schistosomicidal in vivo activity of EPI has been reported.
PB  - Public Library Science, San Francisco
T2  - PLoS Neglected Tropical Diseases
T1  - Anthelmintic Activity In Vivo of Epiisopiloturine against Juvenile and Adult Worms of Schistosoma mansoni
VL  - 9
IS  - 3
DO  - 10.1371/journal.pntd.0003656
UR  - Kon_2834
ER  - 
@article{
author = "Guimaraes, Maria A. and de Oliveira, Rosimeire N. and Veras, Leiz M. C. and Lima, David F. and Campelo, Yuri D. M. and Campos, Stefano Augusto and Kuckelhaus, Selma A. S. and Pinto, Pedro L. S. and Eaton, Peter and Mafud, Ana C. and Mascarenhas, Yvonne P. and Allegretti, Silmara M. and de Moraes, Josue and Lolić, Aleksandar and Verbić, Tatjana and Leite, Jose Roberto S. A.",
year = "2015",
abstract = "Schistosomiasis is a serious disease currently estimated to affect more that 207 million people worldwide. Due to the intensive use of praziquantel, there is increasing concern about the development of drug-resistant strains. Therefore, it is necessary to search for and investigate new potential schistosomicidal compounds. This work reports the in vivo effect of the alkaloid epiisopiloturine (EPI) against adults and juvenile worms of Schistosoma mansoni. EPI was first purified its thermal behavior and theoretical solubility parameters charaterised. In the experiment, mice were treated with EPI over the 21 days post-infection with the doses of 40 and 200 mg/kg, and 45 days post-infection with single doses of 40, 100 and 300 mg/kg. The treatment with EPI at 40 mg/kg was more effective in adult worms when compared with doses of 100 and 300 mg/kg. The treatment with 40 mg/kg in adult worms reduced parasite burden significantly, lead to reduction in hepatosplenomegaly, reduced the egg burden in faeces, and decreased granuloma diameter. Scanning electron microscopy revealed morphological changes to the parasite tegument after treatment, including the loss of important features. Additionally, the in vivo treatment against juvenile with 40 mg/kg showed a reduction of the total worm burden of 50.2%. Histopathological studies were performed on liver, spleen, lung, kidney and brain and EPI was shown to have a DL50 of 8000 mg/kg. Therefore EPI shows potential to be used in schistosomiasis treatment. This is the first time that schistosomicidal in vivo activity of EPI has been reported.",
publisher = "Public Library Science, San Francisco",
journal = "PLoS Neglected Tropical Diseases",
title = "Anthelmintic Activity In Vivo of Epiisopiloturine against Juvenile and Adult Worms of Schistosoma mansoni",
volume = "9",
number = "3",
doi = "10.1371/journal.pntd.0003656",
url = "Kon_2834"
}
Guimaraes, M. A., de Oliveira, R. N., Veras, L. M. C., Lima, D. F., Campelo, Y. D. M., Campos, S. A., Kuckelhaus, S. A. S., Pinto, P. L. S., Eaton, P., Mafud, A. C., Mascarenhas, Y. P., Allegretti, S. M., de Moraes, J., Lolić, A., Verbić, T.,& Leite, J. R. S. A.. (2015). Anthelmintic Activity In Vivo of Epiisopiloturine against Juvenile and Adult Worms of Schistosoma mansoni. in PLoS Neglected Tropical Diseases
Public Library Science, San Francisco., 9(3).
https://doi.org/10.1371/journal.pntd.0003656
Kon_2834
Guimaraes MA, de Oliveira RN, Veras LMC, Lima DF, Campelo YDM, Campos SA, Kuckelhaus SAS, Pinto PLS, Eaton P, Mafud AC, Mascarenhas YP, Allegretti SM, de Moraes J, Lolić A, Verbić T, Leite JRSA. Anthelmintic Activity In Vivo of Epiisopiloturine against Juvenile and Adult Worms of Schistosoma mansoni. in PLoS Neglected Tropical Diseases. 2015;9(3).
doi:10.1371/journal.pntd.0003656
Kon_2834 .
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Supplementary data for article: Lolić, A.; Paíga, P.; Santos, L. H. M. L.; Ramos, S.; Correia, M.; Delerue-Matos, C. Assessment of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawaters of North of Portugal: Occurrence and Environmental Risk. Science of the Total Environment 2015, 508, 240–250. https://doi.org/10.1016/j.scitotenv.2014.11.097

Lolić, Aleksandar; Paiga, Paula; Santos, Lucia H. M. L. M.; Ramos, Sandra; Correia, Manuela; Delerue-Matos, Cristina

(Elsevier Science Bv, Amsterdam, 2015)

TY  - DATA
AU  - Lolić, Aleksandar
AU  - Paiga, Paula
AU  - Santos, Lucia H. M. L. M.
AU  - Ramos, Sandra
AU  - Correia, Manuela
AU  - Delerue-Matos, Cristina
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3340
PB  - Elsevier Science Bv, Amsterdam
T2  - Science of the Total Environment
T1  - Supplementary data for article: Lolić, A.; Paíga, P.; Santos, L. H. M. L.; Ramos, S.; Correia, M.; Delerue-Matos, C. Assessment of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawaters of North of Portugal: Occurrence and Environmental Risk. Science of the Total Environment 2015, 508, 240–250. https://doi.org/10.1016/j.scitotenv.2014.11.097
ER  - 
@misc{
author = "Lolić, Aleksandar and Paiga, Paula and Santos, Lucia H. M. L. M. and Ramos, Sandra and Correia, Manuela and Delerue-Matos, Cristina",
year = "2015",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Science of the Total Environment",
title = "Supplementary data for article: Lolić, A.; Paíga, P.; Santos, L. H. M. L.; Ramos, S.; Correia, M.; Delerue-Matos, C. Assessment of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawaters of North of Portugal: Occurrence and Environmental Risk. Science of the Total Environment 2015, 508, 240–250. https://doi.org/10.1016/j.scitotenv.2014.11.097"
}
Lolić, A., Paiga, P., Santos, L. H. M. L. M., Ramos, S., Correia, M.,& Delerue-Matos, C.. (2015). Supplementary data for article: Lolić, A.; Paíga, P.; Santos, L. H. M. L.; Ramos, S.; Correia, M.; Delerue-Matos, C. Assessment of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawaters of North of Portugal: Occurrence and Environmental Risk. Science of the Total Environment 2015, 508, 240–250. https://doi.org/10.1016/j.scitotenv.2014.11.097. in Science of the Total Environment
Elsevier Science Bv, Amsterdam..
Lolić A, Paiga P, Santos LHMLM, Ramos S, Correia M, Delerue-Matos C. Supplementary data for article: Lolić, A.; Paíga, P.; Santos, L. H. M. L.; Ramos, S.; Correia, M.; Delerue-Matos, C. Assessment of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawaters of North of Portugal: Occurrence and Environmental Risk. Science of the Total Environment 2015, 508, 240–250. https://doi.org/10.1016/j.scitotenv.2014.11.097. in Science of the Total Environment. 2015;..
Lolić, Aleksandar, Paiga, Paula, Santos, Lucia H. M. L. M., Ramos, Sandra, Correia, Manuela, Delerue-Matos, Cristina, "Supplementary data for article: Lolić, A.; Paíga, P.; Santos, L. H. M. L.; Ramos, S.; Correia, M.; Delerue-Matos, C. Assessment of Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals in Seawaters of North of Portugal: Occurrence and Environmental Risk. Science of the Total Environment 2015, 508, 240–250. https://doi.org/10.1016/j.scitotenv.2014.11.097" in Science of the Total Environment (2015).