TY  - JOUR
AU  - Šolaja, Bogdan A.
AU  - Opsenica, Dejan M.
AU  - Smith, Kirsten S.
AU  - Milhous, Wilbur K.
AU  - Terzić-Jovanović, Nataša
AU  - Opsenica, Igor
AU  - Burnett, James C.
AU  - Nuss, Jon
AU  - Gussio, Rick
AU  - Bavari, Sina
PY  - 2008
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/961
AB  - We report on the initial result of the coupling of 4-amino7-chloroquinoline with steroidal and adamantane constituents to provide small molecules with excellent in vitro antimalarial activities (IC90 (W2) down to 6.74 nM). The same entities also inhibit the botulinum neurotoxin serotype A light chain metalloprotease at low nlicromolar levels (7-3 1 yM). Interestingly. structural features imparting increased antimalarial activity also provide increased inetalloprotease inhibition, thus allowing for simultaneous compound optimizations against distinct targets.
PB  - Amer Chemical Soc, Washington
T2  - Journal of Medicinal Chemistry
T1  - Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A
VL  - 51
IS  - 15
SP  - 4388
EP  - 4391
DO  - 10.1021/jm800737y
ER  - 

@article{
author = "Šolaja, Bogdan A. and Opsenica, Dejan M. and Smith, Kirsten S. and Milhous, Wilbur K. and Terzić-Jovanović, Nataša and Opsenica, Igor and Burnett, James C. and Nuss, Jon and Gussio, Rick and Bavari, Sina",
year = "2008",
abstract = "We report on the initial result of the coupling of 4-amino7-chloroquinoline with steroidal and adamantane constituents to provide small molecules with excellent in vitro antimalarial activities (IC90 (W2) down to 6.74 nM). The same entities also inhibit the botulinum neurotoxin serotype A light chain metalloprotease at low nlicromolar levels (7-3 1 yM). Interestingly. structural features imparting increased antimalarial activity also provide increased inetalloprotease inhibition, thus allowing for simultaneous compound optimizations against distinct targets.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Medicinal Chemistry",
title = "Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A",
volume = "51",
number = "15",
pages = "4388-4391",
doi = "10.1021/jm800737y"
}

Šolaja, B. A., Opsenica, D. M., Smith, K. S., Milhous, W. K., Terzić-Jovanović, N., Opsenica, I., Burnett, J. C., Nuss, J., Gussio, R.,& Bavari, S.. (2008). Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A. in Journal of Medicinal Chemistry
Amer Chemical Soc, Washington., 51(15), 4388-4391.
https://doi.org/10.1021/jm800737y

Šolaja BA, Opsenica DM, Smith KS, Milhous WK, Terzić-Jovanović N, Opsenica I, Burnett JC, Nuss J, Gussio R, Bavari S. Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A. in Journal of Medicinal Chemistry. 2008;51(15):4388-4391.
doi:10.1021/jm800737y .

Šolaja, Bogdan A., Opsenica, Dejan M., Smith, Kirsten S., Milhous, Wilbur K., Terzić-Jovanović, Nataša, Opsenica, Igor, Burnett, James C., Nuss, Jon, Gussio, Rick, Bavari, Sina, "Novel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype A" in Journal of Medicinal Chemistry, 51, no. 15 (2008):4388-4391,
https://doi.org/10.1021/jm800737y . .