Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković')

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Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (en)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 451-03-68/2020-14/200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (sr_RS)
Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 451-03-68/2020-14/200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (sr)
Authors

Publications

Antibacterial Fractions from Erodium cicutarium Exposed—Clinical Strains of Staphylococcus aureus in Focus

Ljoljić Bilić, Vanja; Gašić, Uroš M.; Milojković-Opsenica, Dušanka; Rimac, Hrvoje; Vuković Rodriguez, Jadranka; Vlainić, Josipa; Brlek‐Gorski, Diana; Kosalec, Ivan

(MDPI, 2022)

TY  - JOUR
AU  - Ljoljić Bilić, Vanja
AU  - Gašić, Uroš M.
AU  - Milojković-Opsenica, Dušanka
AU  - Rimac, Hrvoje
AU  - Vuković Rodriguez, Jadranka
AU  - Vlainić, Josipa
AU  - Brlek‐Gorski, Diana
AU  - Kosalec, Ivan
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5197
AB  - Followed by a buildup of its phytochemical profile, Erodium cicutarium is being subjected
to antimicrobial investigation guided with its ethnobotanical use. The results of performed in vitro
screening on Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans strains, show that
E. cicutarium has antimicrobial activity, with a particular emphasis on clinical S. aureus strains—
both the methicillin sensitive (MSSA) and the methicillin resistant (MRSA) S. aureus. Experimental
design consisted of general methods (the serial microdilution broth assay and the agar well diffusion
assay), as well as observing bactericidal/bacteriostatic activity through time (the “time‐kill”
assay), investigating the effect on cell wall integrity and biofilm formation, and modulation of bacterial
hemolysis. Observed antibacterial activity from above‐described methods led to further activity‐
guided fractionation of water and methanol extracts using bioautography coupled with UHPLCLTQ
OrbiTrap MS4. It was determined that active fractions are predominantly formed by gallic acid
derivatives and flavonol glycosides. Among the most active phytochemicals, galloyl‐shikimic acid
was identified as the most abundant compound. These results point to a direct connection between
galloyl‐shikimic acid and the observed E. cicutarium antibacterial activity, and open several new
research approaches for future investigation
PB  - MDPI
T2  - Аntibiotics
T1  - Antibacterial Fractions from Erodium cicutarium Exposed—Clinical Strains of Staphylococcus aureus in Focus
VL  - 11
SP  - 492
DO  - 10.3390/antibiotics11040492
ER  - 
@article{
author = "Ljoljić Bilić, Vanja and Gašić, Uroš M. and Milojković-Opsenica, Dušanka and Rimac, Hrvoje and Vuković Rodriguez, Jadranka and Vlainić, Josipa and Brlek‐Gorski, Diana and Kosalec, Ivan",
year = "2022",
abstract = "Followed by a buildup of its phytochemical profile, Erodium cicutarium is being subjected
to antimicrobial investigation guided with its ethnobotanical use. The results of performed in vitro
screening on Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans strains, show that
E. cicutarium has antimicrobial activity, with a particular emphasis on clinical S. aureus strains—
both the methicillin sensitive (MSSA) and the methicillin resistant (MRSA) S. aureus. Experimental
design consisted of general methods (the serial microdilution broth assay and the agar well diffusion
assay), as well as observing bactericidal/bacteriostatic activity through time (the “time‐kill”
assay), investigating the effect on cell wall integrity and biofilm formation, and modulation of bacterial
hemolysis. Observed antibacterial activity from above‐described methods led to further activity‐
guided fractionation of water and methanol extracts using bioautography coupled with UHPLCLTQ
OrbiTrap MS4. It was determined that active fractions are predominantly formed by gallic acid
derivatives and flavonol glycosides. Among the most active phytochemicals, galloyl‐shikimic acid
was identified as the most abundant compound. These results point to a direct connection between
galloyl‐shikimic acid and the observed E. cicutarium antibacterial activity, and open several new
research approaches for future investigation",
publisher = "MDPI",
journal = "Аntibiotics",
title = "Antibacterial Fractions from Erodium cicutarium Exposed—Clinical Strains of Staphylococcus aureus in Focus",
volume = "11",
pages = "492",
doi = "10.3390/antibiotics11040492"
}
Ljoljić Bilić, V., Gašić, U. M., Milojković-Opsenica, D., Rimac, H., Vuković Rodriguez, J., Vlainić, J., Brlek‐Gorski, D.,& Kosalec, I.. (2022). Antibacterial Fractions from Erodium cicutarium Exposed—Clinical Strains of Staphylococcus aureus in Focus. in Аntibiotics
MDPI., 11, 492.
https://doi.org/10.3390/antibiotics11040492
Ljoljić Bilić V, Gašić UM, Milojković-Opsenica D, Rimac H, Vuković Rodriguez J, Vlainić J, Brlek‐Gorski D, Kosalec I. Antibacterial Fractions from Erodium cicutarium Exposed—Clinical Strains of Staphylococcus aureus in Focus. in Аntibiotics. 2022;11:492.
doi:10.3390/antibiotics11040492 .
Ljoljić Bilić, Vanja, Gašić, Uroš M., Milojković-Opsenica, Dušanka, Rimac, Hrvoje, Vuković Rodriguez, Jadranka, Vlainić, Josipa, Brlek‐Gorski, Diana, Kosalec, Ivan, "Antibacterial Fractions from Erodium cicutarium Exposed—Clinical Strains of Staphylococcus aureus in Focus" in Аntibiotics, 11 (2022):492,
https://doi.org/10.3390/antibiotics11040492 . .
1

Protective role of strawberry tree (Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro

Jurič, Andreja; Brčić Karačonji, Irena; Žunec, Suzana; Katić, Anja; Gašić, Uroš M.; Milojković-Opsenica, Dušanka; Kopjar, Nevenka

(Taylor and Francis, 2022)

TY  - JOUR
AU  - Jurič, Andreja
AU  - Brčić Karačonji, Irena
AU  - Žunec, Suzana
AU  - Katić, Anja
AU  - Gašić, Uroš M.
AU  - Milojković-Opsenica, Dušanka
AU  - Kopjar, Nevenka
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5199
AB  - Strawberry tree (Arbutus unedo L.) honey (STH) is widely used as part of traditional medicine
in the Mediterranean area, especially in the treatment of wounds, burns and infections. In
this study, we investigated the cyto-/genoprotective properties of STH at cell level following
short-term exposure to UVB radiation at 2 kJ/m2. Isolated human peripheral blood lymphocytes
(PBL) were selected as model cells. Phenolics in STH were determined using an ultrahigh-
performance liquid chromatograph (UHPLC) coupled to a linear ion trap-Orbitrap hybrid
mass spectrometer (LTQ Orbitrap MS), while homogentisic acid (HGA) was quantified using a
gas chromatograph-mass spectrometer (GC-MS). Primary DNA damage in PBLs treated with
STH before and after irradiation was assessed by alkaline comet assay, while their viability
was determined using the apoptosis/necrosis assay. The levels of thiobarbituric acid reactive
substances (TBARS) and glutathione (GSH) were determined in plasma samples. STH applied
as pre-treatment at a concentration equivalent to its average daily portion efficiently counteracted
the cytotoxic and genotoxic effects and diminished UVB-induced oxidative stress.
Post-radiation treatment with STH was not as beneficial. Protective effects could be associated
to the complex phytochemical profile of STH and the high content of HGA (306.8mg/
kg). It was confirmed that an intake of a complex mixture of bioactive constituents as STH
prior to potential cyto/genotoxic insults stimulated a broad-spectrum of protective mechanisms,
including intracellular antioxidative defence and DNA repair systems that helped pretreated
cells to counteract harmful exposures more efficiently.
PB  - Taylor and Francis
T2  - Journal of Apicultural Research
T1  - Protective role of strawberry tree (Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro
SP  - 1
EP  - 10
DO  - 10.1080/00218839.2022.2047421
ER  - 
@article{
author = "Jurič, Andreja and Brčić Karačonji, Irena and Žunec, Suzana and Katić, Anja and Gašić, Uroš M. and Milojković-Opsenica, Dušanka and Kopjar, Nevenka",
year = "2022",
abstract = "Strawberry tree (Arbutus unedo L.) honey (STH) is widely used as part of traditional medicine
in the Mediterranean area, especially in the treatment of wounds, burns and infections. In
this study, we investigated the cyto-/genoprotective properties of STH at cell level following
short-term exposure to UVB radiation at 2 kJ/m2. Isolated human peripheral blood lymphocytes
(PBL) were selected as model cells. Phenolics in STH were determined using an ultrahigh-
performance liquid chromatograph (UHPLC) coupled to a linear ion trap-Orbitrap hybrid
mass spectrometer (LTQ Orbitrap MS), while homogentisic acid (HGA) was quantified using a
gas chromatograph-mass spectrometer (GC-MS). Primary DNA damage in PBLs treated with
STH before and after irradiation was assessed by alkaline comet assay, while their viability
was determined using the apoptosis/necrosis assay. The levels of thiobarbituric acid reactive
substances (TBARS) and glutathione (GSH) were determined in plasma samples. STH applied
as pre-treatment at a concentration equivalent to its average daily portion efficiently counteracted
the cytotoxic and genotoxic effects and diminished UVB-induced oxidative stress.
Post-radiation treatment with STH was not as beneficial. Protective effects could be associated
to the complex phytochemical profile of STH and the high content of HGA (306.8mg/
kg). It was confirmed that an intake of a complex mixture of bioactive constituents as STH
prior to potential cyto/genotoxic insults stimulated a broad-spectrum of protective mechanisms,
including intracellular antioxidative defence and DNA repair systems that helped pretreated
cells to counteract harmful exposures more efficiently.",
publisher = "Taylor and Francis",
journal = "Journal of Apicultural Research",
title = "Protective role of strawberry tree (Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro",
pages = "1-10",
doi = "10.1080/00218839.2022.2047421"
}
Jurič, A., Brčić Karačonji, I., Žunec, S., Katić, A., Gašić, U. M., Milojković-Opsenica, D.,& Kopjar, N.. (2022). Protective role of strawberry tree (Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro. in Journal of Apicultural Research
Taylor and Francis., 1-10.
https://doi.org/10.1080/00218839.2022.2047421
Jurič A, Brčić Karačonji I, Žunec S, Katić A, Gašić UM, Milojković-Opsenica D, Kopjar N. Protective role of strawberry tree (Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro. in Journal of Apicultural Research. 2022;:1-10.
doi:10.1080/00218839.2022.2047421 .
Jurič, Andreja, Brčić Karačonji, Irena, Žunec, Suzana, Katić, Anja, Gašić, Uroš M., Milojković-Opsenica, Dušanka, Kopjar, Nevenka, "Protective role of strawberry tree (Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro" in Journal of Apicultural Research (2022):1-10,
https://doi.org/10.1080/00218839.2022.2047421 . .

Influence of Different Defoliation Timings on Quality and Phenolic Composition of the Wines Produced from the Serbian Autochthonous Variety Prokupac (Vitis vinifera L.)

Ćirković, Dušica; Matijašević, Saša; Ćirković, Bratislav; Laketić, Darko; Jovanović, Zoran; Kostić, Boban; Bešlić, Zoran; Sredojević, Milica; Tešić, Živoslav; Banjanac, Tijana; Gašić, Uroš M.

(MDPI, 2022)

TY  - JOUR
AU  - Ćirković, Dušica
AU  - Matijašević, Saša
AU  - Ćirković, Bratislav
AU  - Laketić, Darko
AU  - Jovanović, Zoran
AU  - Kostić, Boban
AU  - Bešlić, Zoran
AU  - Sredojević, Milica
AU  - Tešić, Živoslav
AU  - Banjanac, Tijana
AU  - Gašić, Uroš M.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5317
AB  - The variety Prokupac is the dominant variety in the vineyards of Southern Serbia, which
produces quality wines of characteristic and unique tastes. In the agroecological conditions of the
Prokuplje vine district, the influence of manual defoliation on the phenolic profile of the wine
produced from the variety Prokupac was examined. Four experimental treatments with different
timings of manual defoliation were applied: early defoliation—treatment I, early defoliation—
treatment II, late defoliation—treatment III and the control. The phenolic profile of the wine
was determined for the three treatments of defoliation and the control treatment. Additionally,
a multivariate analysis was applied on the obtained results, together with already published data
(grape seeds and skins phenolic profiles). Identification and quantification of the phenolic compounds was performed using ultra-high-performance liquid chromatography (UHPLC) with an ultraviolet multi-diode detector (DAD) and mass detector with three analyzers—triple quadrupole (QQQ). Based on the obtained results, it was determined that there are significant differences between the experimental treatments in the content of individual polyphenols, total polyphenols and the antioxidant capacity. Twenty (20) phenolic compounds were identified in the wine samples of the experimental treatments. Defoliation significantly affected the variations of the contents of
phenolic acids and flavonoids. In treatment III, the highest content of gallic acid was obtained,
while the treatments with early defoliation did not differ in relation to the control sample. Early
defoliation in treatments I and II had an effect on the phenolic composition of the wine by favoring
the accumulation of flavonol, while the content of hydroxycinnamic acid and total anthocyanins
(TAC) was higher in treatment III. The TAC increases with later defoliation. The wines obtained by
the defoliation treatments did not show higher antioxidant activity compared to the control sample. A principal component analysis resulted in clustering of the samples based on the phenolic components characteristic for each group of samples.
PB  - MDPI
T2  - Horticulturae
T1  - Influence of Different Defoliation Timings on Quality and Phenolic Composition of the Wines Produced from the Serbian Autochthonous Variety Prokupac (Vitis vinifera L.)
VL  - 8
SP  - 296
DO  - 10.3390/horticulturae8040296
ER  - 
@article{
author = "Ćirković, Dušica and Matijašević, Saša and Ćirković, Bratislav and Laketić, Darko and Jovanović, Zoran and Kostić, Boban and Bešlić, Zoran and Sredojević, Milica and Tešić, Živoslav and Banjanac, Tijana and Gašić, Uroš M.",
year = "2022",
abstract = "The variety Prokupac is the dominant variety in the vineyards of Southern Serbia, which
produces quality wines of characteristic and unique tastes. In the agroecological conditions of the
Prokuplje vine district, the influence of manual defoliation on the phenolic profile of the wine
produced from the variety Prokupac was examined. Four experimental treatments with different
timings of manual defoliation were applied: early defoliation—treatment I, early defoliation—
treatment II, late defoliation—treatment III and the control. The phenolic profile of the wine
was determined for the three treatments of defoliation and the control treatment. Additionally,
a multivariate analysis was applied on the obtained results, together with already published data
(grape seeds and skins phenolic profiles). Identification and quantification of the phenolic compounds was performed using ultra-high-performance liquid chromatography (UHPLC) with an ultraviolet multi-diode detector (DAD) and mass detector with three analyzers—triple quadrupole (QQQ). Based on the obtained results, it was determined that there are significant differences between the experimental treatments in the content of individual polyphenols, total polyphenols and the antioxidant capacity. Twenty (20) phenolic compounds were identified in the wine samples of the experimental treatments. Defoliation significantly affected the variations of the contents of
phenolic acids and flavonoids. In treatment III, the highest content of gallic acid was obtained,
while the treatments with early defoliation did not differ in relation to the control sample. Early
defoliation in treatments I and II had an effect on the phenolic composition of the wine by favoring
the accumulation of flavonol, while the content of hydroxycinnamic acid and total anthocyanins
(TAC) was higher in treatment III. The TAC increases with later defoliation. The wines obtained by
the defoliation treatments did not show higher antioxidant activity compared to the control sample. A principal component analysis resulted in clustering of the samples based on the phenolic components characteristic for each group of samples.",
publisher = "MDPI",
journal = "Horticulturae",
title = "Influence of Different Defoliation Timings on Quality and Phenolic Composition of the Wines Produced from the Serbian Autochthonous Variety Prokupac (Vitis vinifera L.)",
volume = "8",
pages = "296",
doi = "10.3390/horticulturae8040296"
}
Ćirković, D., Matijašević, S., Ćirković, B., Laketić, D., Jovanović, Z., Kostić, B., Bešlić, Z., Sredojević, M., Tešić, Ž., Banjanac, T.,& Gašić, U. M.. (2022). Influence of Different Defoliation Timings on Quality and Phenolic Composition of the Wines Produced from the Serbian Autochthonous Variety Prokupac (Vitis vinifera L.). in Horticulturae
MDPI., 8, 296.
https://doi.org/10.3390/horticulturae8040296
Ćirković D, Matijašević S, Ćirković B, Laketić D, Jovanović Z, Kostić B, Bešlić Z, Sredojević M, Tešić Ž, Banjanac T, Gašić UM. Influence of Different Defoliation Timings on Quality and Phenolic Composition of the Wines Produced from the Serbian Autochthonous Variety Prokupac (Vitis vinifera L.). in Horticulturae. 2022;8:296.
doi:10.3390/horticulturae8040296 .
Ćirković, Dušica, Matijašević, Saša, Ćirković, Bratislav, Laketić, Darko, Jovanović, Zoran, Kostić, Boban, Bešlić, Zoran, Sredojević, Milica, Tešić, Živoslav, Banjanac, Tijana, Gašić, Uroš M., "Influence of Different Defoliation Timings on Quality and Phenolic Composition of the Wines Produced from the Serbian Autochthonous Variety Prokupac (Vitis vinifera L.)" in Horticulturae, 8 (2022):296,
https://doi.org/10.3390/horticulturae8040296 . .
2

Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems

Fotirić-Akšić, Milica M.; Dabić-Zagorac, Dragana; Gašić, Uroš M.; Tosti, Tomislav; Natić, Maja; Meland, Mekjell

(MDPI, 2022)

TY  - JOUR
AU  - Fotirić-Akšić, Milica M.
AU  - Dabić-Zagorac, Dragana
AU  - Gašić, Uroš M.
AU  - Tosti, Tomislav
AU  - Natić, Maja
AU  - Meland, Mekjell
PY  - 2022
UR  - https://www.mdpi.com/2071-1050/14/9/5300
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5178
AB  - The aim of this study was to compare total phenolic content (TPC), radical-scavenging activity (RSA), total anthocyanin content (TAC), sugar and polyphenolic profiles of two apple cultivars (‘Discovery’ and ‘Red Aroma Orelind’) from organic and integrated production systems in climatic conditions of Western Norway. Sixteen sugars and four sugar alcohols and 19 polyphenols were found in the peel, but less polyphenols were detected in the pulp. The peel of both apples and in both production systems had significantly higher TPC and RSA than the pulp. The peel from integrated apples had higher TPC than the peel from organic apples, while organic apples had higher TAC than the integrated. Sucrose and glucose levels were higher in organic apples; fructose was cultivar dependent while minor sugars were higher in integrated fruits. The most abundant polyphenolic compound in the peel of the tested cultivars was quercetin 3-O-galactoside, while chlorogenic acid was most abundant in the pulp. Regarding polyphenols, phloretin, phloridzin, protocatechuic acid, baicalein and naringenin were higher in organic apple, while quercetin 3-O-galactoside, kaempferol 3-O-glucoside, chlorogenic acid and syringic acid was higher in integrated fruits. In conclusion, organic ‘Discovery’ and integrated ‘Red Aroma Orelind’ had higher bioavailability of health related compounds from the peel and the pulp.
PB  - MDPI
T2  - Sustainability
T2  - Sustainability
T1  - Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems
VL  - 14
IS  - 9
SP  - 5300
DO  - 10.3390/su14095300
ER  - 
@article{
author = "Fotirić-Akšić, Milica M. and Dabić-Zagorac, Dragana and Gašić, Uroš M. and Tosti, Tomislav and Natić, Maja and Meland, Mekjell",
year = "2022",
abstract = "The aim of this study was to compare total phenolic content (TPC), radical-scavenging activity (RSA), total anthocyanin content (TAC), sugar and polyphenolic profiles of two apple cultivars (‘Discovery’ and ‘Red Aroma Orelind’) from organic and integrated production systems in climatic conditions of Western Norway. Sixteen sugars and four sugar alcohols and 19 polyphenols were found in the peel, but less polyphenols were detected in the pulp. The peel of both apples and in both production systems had significantly higher TPC and RSA than the pulp. The peel from integrated apples had higher TPC than the peel from organic apples, while organic apples had higher TAC than the integrated. Sucrose and glucose levels were higher in organic apples; fructose was cultivar dependent while minor sugars were higher in integrated fruits. The most abundant polyphenolic compound in the peel of the tested cultivars was quercetin 3-O-galactoside, while chlorogenic acid was most abundant in the pulp. Regarding polyphenols, phloretin, phloridzin, protocatechuic acid, baicalein and naringenin were higher in organic apple, while quercetin 3-O-galactoside, kaempferol 3-O-glucoside, chlorogenic acid and syringic acid was higher in integrated fruits. In conclusion, organic ‘Discovery’ and integrated ‘Red Aroma Orelind’ had higher bioavailability of health related compounds from the peel and the pulp.",
publisher = "MDPI",
journal = "Sustainability, Sustainability",
title = "Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems",
volume = "14",
number = "9",
pages = "5300",
doi = "10.3390/su14095300"
}
Fotirić-Akšić, M. M., Dabić-Zagorac, D., Gašić, U. M., Tosti, T., Natić, M.,& Meland, M.. (2022). Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems. in Sustainability
MDPI., 14(9), 5300.
https://doi.org/10.3390/su14095300
Fotirić-Akšić MM, Dabić-Zagorac D, Gašić UM, Tosti T, Natić M, Meland M. Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems. in Sustainability. 2022;14(9):5300.
doi:10.3390/su14095300 .
Fotirić-Akšić, Milica M., Dabić-Zagorac, Dragana, Gašić, Uroš M., Tosti, Tomislav, Natić, Maja, Meland, Mekjell, "Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems" in Sustainability, 14, no. 9 (2022):5300,
https://doi.org/10.3390/su14095300 . .
1

Hieracium waldsteinii (Asteraceae) and Onosma stellulata (Boraginaceae) as a Source of Antioxidant and Antimicrobial Agents

Kostić, Aleksandar Ž.; Mačukanović-Jocić, Marina P.; Milinčić, Danijel D.; Petrović, Jovana D.; Gašić, Uroš M.; Gligorijević, Nevenka N.; Jarić, Snežana V.; Soković, Marina D.; Tešić, Živoslav Lj.; Pešić, Mirjana B.

(Wiley, 2022)

TY  - JOUR
AU  - Kostić, Aleksandar Ž.
AU  - Mačukanović-Jocić, Marina P.
AU  - Milinčić, Danijel D.
AU  - Petrović, Jovana D.
AU  - Gašić, Uroš M.
AU  - Gligorijević, Nevenka N.
AU  - Jarić, Snežana V.
AU  - Soković, Marina D.
AU  - Tešić, Živoslav Lj.
AU  - Pešić, Mirjana B.
PY  - 2022
UR  - http://www.ncbi.nlm.nih.gov/pubmed/35213785
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5203
AB  - The current study aimed to phytochemically characterize (including a detailed phenolic profile) two endemic Balkan's species (Hieracium waldsteinii and Onosma stellulata) and determine their possible application as a source of natural antioxidant and antimicrobial agents. The main phenolic compound in both species (in all examined parts) was chlorogenic acid. Eriodictyol, genistein and naringenin were quantified only in H. waldsteinii while isorhamnetin-3-O-rutinoside and sinapic acid were characteristic for O. stellulata. The highest antioxidant activity (98 mg AAE/g dry weight for TAC assay) was ascribed to the flower extract of H. waldsteinii while the lowest results (∼4.3 mg AAE/g dry weight for FRP assay) were exhibited by the extracts obtained from the plant's stem. Antimicrobial assays showed moderate antibacterial, i. e., moderate/strong activity against several tested fungi (in particular Trichoderma viride). Correlation analysis revealed strong positive connection between phenolic compounds and reducing power of extracts as well as between total phenolic and flavonoid content and the obtained minimal inhibitory concentration recorded in antibacterial assays.
PB  - Wiley
T1  - Hieracium waldsteinii (Asteraceae) and Onosma stellulata (Boraginaceae) as a Source of Antioxidant and Antimicrobial Agents
VL  - 19
IS  - 4
SP  - e202200069
DO  - 10.1002/cbdv.202200069
ER  - 
@article{
author = "Kostić, Aleksandar Ž. and Mačukanović-Jocić, Marina P. and Milinčić, Danijel D. and Petrović, Jovana D. and Gašić, Uroš M. and Gligorijević, Nevenka N. and Jarić, Snežana V. and Soković, Marina D. and Tešić, Živoslav Lj. and Pešić, Mirjana B.",
year = "2022",
abstract = "The current study aimed to phytochemically characterize (including a detailed phenolic profile) two endemic Balkan's species (Hieracium waldsteinii and Onosma stellulata) and determine their possible application as a source of natural antioxidant and antimicrobial agents. The main phenolic compound in both species (in all examined parts) was chlorogenic acid. Eriodictyol, genistein and naringenin were quantified only in H. waldsteinii while isorhamnetin-3-O-rutinoside and sinapic acid were characteristic for O. stellulata. The highest antioxidant activity (98 mg AAE/g dry weight for TAC assay) was ascribed to the flower extract of H. waldsteinii while the lowest results (∼4.3 mg AAE/g dry weight for FRP assay) were exhibited by the extracts obtained from the plant's stem. Antimicrobial assays showed moderate antibacterial, i. e., moderate/strong activity against several tested fungi (in particular Trichoderma viride). Correlation analysis revealed strong positive connection between phenolic compounds and reducing power of extracts as well as between total phenolic and flavonoid content and the obtained minimal inhibitory concentration recorded in antibacterial assays.",
publisher = "Wiley",
title = "Hieracium waldsteinii (Asteraceae) and Onosma stellulata (Boraginaceae) as a Source of Antioxidant and Antimicrobial Agents",
volume = "19",
number = "4",
pages = "e202200069",
doi = "10.1002/cbdv.202200069"
}
Kostić, A. Ž., Mačukanović-Jocić, M. P., Milinčić, D. D., Petrović, J. D., Gašić, U. M., Gligorijević, N. N., Jarić, S. V., Soković, M. D., Tešić, Ž. Lj.,& Pešić, M. B.. (2022). Hieracium waldsteinii (Asteraceae) and Onosma stellulata (Boraginaceae) as a Source of Antioxidant and Antimicrobial Agents. 
Wiley., 19(4), e202200069.
https://doi.org/10.1002/cbdv.202200069
Kostić AŽ, Mačukanović-Jocić MP, Milinčić DD, Petrović JD, Gašić UM, Gligorijević NN, Jarić SV, Soković MD, Tešić ŽL, Pešić MB. Hieracium waldsteinii (Asteraceae) and Onosma stellulata (Boraginaceae) as a Source of Antioxidant and Antimicrobial Agents. 2022;19(4):e202200069.
doi:10.1002/cbdv.202200069 .
Kostić, Aleksandar Ž., Mačukanović-Jocić, Marina P., Milinčić, Danijel D., Petrović, Jovana D., Gašić, Uroš M., Gligorijević, Nevenka N., Jarić, Snežana V., Soković, Marina D., Tešić, Živoslav Lj., Pešić, Mirjana B., "Hieracium waldsteinii (Asteraceae) and Onosma stellulata (Boraginaceae) as a Source of Antioxidant and Antimicrobial Agents", 19, no. 4 (2022):e202200069,
https://doi.org/10.1002/cbdv.202200069 . .
1
1

Terpene relationships among some soft and hard pine species

Krstić, Gordana B.; Nikolić, Biljana; Todosijević, Marina; Mitić, Zorica; Stanković-Jeremić, Jovana; Cvetković, Mirjana; Bojović, Srđan R.; Marin, Petar D.

(2022)

TY  - JOUR
AU  - Krstić, Gordana B.
AU  - Nikolić, Biljana
AU  - Todosijević, Marina
AU  - Mitić, Zorica
AU  - Stanković-Jeremić, Jovana
AU  - Cvetković, Mirjana
AU  - Bojović, Srđan R.
AU  - Marin, Petar D.
PY  - 2022
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=1821-21582201039K
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5180
AB  - In this study we have reported the chemical composition of the essential oils obtained from the needles of twelve Pinus taxa, belonging to the subgenera Pinus (sections Pinus and Trifoliae) and Strobus (sect. Quinquefoliae). Monoterpenes dominated over sesquiterpenes in most of the investigated taxa of both subgenera, except in representatives of the subsection Pinaster, subgenus Pinus. α-Pinene was the most abundant terpene in eight pines, but other dominant terpenes were found in some taxa - trans-caryophyllene, germacrene D, abietadiene and β-pinene. In the subsect. Pinaster, the most dominant compounds varied from species to species. In addition, P. halepensis and P. pinaster had the highest percentage of diterpenes, while P. heldreichii was the richest in germacrene D. In the PCA and cluster analyses, three species from the subsect. Pinaster emerged as the most distant: P. halepensis, P. pinaster, and P. heldreichii. In addition, the possible taxonomic implications of the terpene profile in the analysed Pinus taxa were also discussed.
T2  - Botanica Serbica
T1  - Terpene relationships among some soft and hard pine species
VL  - 46
IS  - 1
SP  - 39
EP  - 48
DO  - 10.2298/BOTSERB2201039K
ER  - 
@article{
author = "Krstić, Gordana B. and Nikolić, Biljana and Todosijević, Marina and Mitić, Zorica and Stanković-Jeremić, Jovana and Cvetković, Mirjana and Bojović, Srđan R. and Marin, Petar D.",
year = "2022",
abstract = "In this study we have reported the chemical composition of the essential oils obtained from the needles of twelve Pinus taxa, belonging to the subgenera Pinus (sections Pinus and Trifoliae) and Strobus (sect. Quinquefoliae). Monoterpenes dominated over sesquiterpenes in most of the investigated taxa of both subgenera, except in representatives of the subsection Pinaster, subgenus Pinus. α-Pinene was the most abundant terpene in eight pines, but other dominant terpenes were found in some taxa - trans-caryophyllene, germacrene D, abietadiene and β-pinene. In the subsect. Pinaster, the most dominant compounds varied from species to species. In addition, P. halepensis and P. pinaster had the highest percentage of diterpenes, while P. heldreichii was the richest in germacrene D. In the PCA and cluster analyses, three species from the subsect. Pinaster emerged as the most distant: P. halepensis, P. pinaster, and P. heldreichii. In addition, the possible taxonomic implications of the terpene profile in the analysed Pinus taxa were also discussed.",
journal = "Botanica Serbica",
title = "Terpene relationships among some soft and hard pine species",
volume = "46",
number = "1",
pages = "39-48",
doi = "10.2298/BOTSERB2201039K"
}
Krstić, G. B., Nikolić, B., Todosijević, M., Mitić, Z., Stanković-Jeremić, J., Cvetković, M., Bojović, S. R.,& Marin, P. D.. (2022). Terpene relationships among some soft and hard pine species. in Botanica Serbica, 46(1), 39-48.
https://doi.org/10.2298/BOTSERB2201039K
Krstić GB, Nikolić B, Todosijević M, Mitić Z, Stanković-Jeremić J, Cvetković M, Bojović SR, Marin PD. Terpene relationships among some soft and hard pine species. in Botanica Serbica. 2022;46(1):39-48.
doi:10.2298/BOTSERB2201039K .
Krstić, Gordana B., Nikolić, Biljana, Todosijević, Marina, Mitić, Zorica, Stanković-Jeremić, Jovana, Cvetković, Mirjana, Bojović, Srđan R., Marin, Petar D., "Terpene relationships among some soft and hard pine species" in Botanica Serbica, 46, no. 1 (2022):39-48,
https://doi.org/10.2298/BOTSERB2201039K . .

“Scent of a fruit fly”: Cuticular chemoprofilesafter mating in differently fedDrosophilamelanogaster(Diptera: Drosophilidae) strains

Pavković‐Lučić, Sofija; Trajković, Jelena; Miličić, Dragana; Anđelković, Boban D.; Lučić, Luka; Savić, Tatjana; Vujisić, Ljubodrag V.

(Wiley, 2022)

TY  - JOUR
AU  - Pavković‐Lučić, Sofija
AU  - Trajković, Jelena
AU  - Miličić, Dragana
AU  - Anđelković, Boban D.
AU  - Lučić, Luka
AU  - Savić, Tatjana
AU  - Vujisić, Ljubodrag V.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5019
AB  - n the world of complex smells in natural environment,feeding and mating represent two important olfactory‐guided behaviors inDrosophila melanogaster(Diptera:Drosophilidae). Diet affects the chemoprofile compositionof the individuals, which, indirectly, may significantly affecttheir mating success. In this study, chemoprofiles of re-cently mated flies belonging to fourD. melanogasterstrains,which were fed for many generations on different sub-strates (standard cornmeal—S strain; banana—B strain;carrot—C strain; tomato—T strain) were identified andquantified. In total, 67 chemical compounds were identi-fied: 48 compounds were extracted from males maintainedon banana and carrot, and 47 compounds from malesmaintained on cornmeal and tomato substrates, while totalof 60 compounds were identified in females from allstrains. The strains and the sexes significantly differed inqualitative nature of their chemoprofiles after mating. Sig-nificant differences in the relative amount of three majormale  pheromones  (cis‐vaccenyl  acetate—cVA,  (Z)‐7‐pentacosene, and (Z)‐7‐tricosene) and in female pheromone(Z,Z)‐7,11‐nonacosadiene among strains were also re-corded. Furthermore, multivariate analysis of variance(MANOVA) pointed to significant differences between irgin and mated individuals of all strains and within bothsexes. Differences in some of the well known sex pher-omones were also identified when comparing their relativeamount before and after mating. The presence of typicalmale pheromones in females, and vice versa may indicatetheir bidirectional transfer during copulation. Our resultsconfirm significant effect of mating status on cuticular hy-drocarbon (CHC) phenotypes in differently fedD. melano-gasterflies.
PB  - Wiley
T2  - Archives of Insect Biochemistry and Physiology
T1  - “Scent of a fruit fly”: Cuticular chemoprofilesafter mating in differently fedDrosophilamelanogaster(Diptera: Drosophilidae) strains
VL  - 109
IS  - 3
SP  - e21866
DO  - 10.1002/arch.21866
ER  - 
@article{
author = "Pavković‐Lučić, Sofija and Trajković, Jelena and Miličić, Dragana and Anđelković, Boban D. and Lučić, Luka and Savić, Tatjana and Vujisić, Ljubodrag V.",
year = "2022",
abstract = "n the world of complex smells in natural environment,feeding and mating represent two important olfactory‐guided behaviors inDrosophila melanogaster(Diptera:Drosophilidae). Diet affects the chemoprofile compositionof the individuals, which, indirectly, may significantly affecttheir mating success. In this study, chemoprofiles of re-cently mated flies belonging to fourD. melanogasterstrains,which were fed for many generations on different sub-strates (standard cornmeal—S strain; banana—B strain;carrot—C strain; tomato—T strain) were identified andquantified. In total, 67 chemical compounds were identi-fied: 48 compounds were extracted from males maintainedon banana and carrot, and 47 compounds from malesmaintained on cornmeal and tomato substrates, while totalof 60 compounds were identified in females from allstrains. The strains and the sexes significantly differed inqualitative nature of their chemoprofiles after mating. Sig-nificant differences in the relative amount of three majormale  pheromones  (cis‐vaccenyl  acetate—cVA,  (Z)‐7‐pentacosene, and (Z)‐7‐tricosene) and in female pheromone(Z,Z)‐7,11‐nonacosadiene among strains were also re-corded. Furthermore, multivariate analysis of variance(MANOVA) pointed to significant differences between irgin and mated individuals of all strains and within bothsexes. Differences in some of the well known sex pher-omones were also identified when comparing their relativeamount before and after mating. The presence of typicalmale pheromones in females, and vice versa may indicatetheir bidirectional transfer during copulation. Our resultsconfirm significant effect of mating status on cuticular hy-drocarbon (CHC) phenotypes in differently fedD. melano-gasterflies.",
publisher = "Wiley",
journal = "Archives of Insect Biochemistry and Physiology",
title = "“Scent of a fruit fly”: Cuticular chemoprofilesafter mating in differently fedDrosophilamelanogaster(Diptera: Drosophilidae) strains",
volume = "109",
number = "3",
pages = "e21866",
doi = "10.1002/arch.21866"
}
Pavković‐Lučić, S., Trajković, J., Miličić, D., Anđelković, B. D., Lučić, L., Savić, T.,& Vujisić, L. V.. (2022). “Scent of a fruit fly”: Cuticular chemoprofilesafter mating in differently fedDrosophilamelanogaster(Diptera: Drosophilidae) strains. in Archives of Insect Biochemistry and Physiology
Wiley., 109(3), e21866.
https://doi.org/10.1002/arch.21866
Pavković‐Lučić S, Trajković J, Miličić D, Anđelković BD, Lučić L, Savić T, Vujisić LV. “Scent of a fruit fly”: Cuticular chemoprofilesafter mating in differently fedDrosophilamelanogaster(Diptera: Drosophilidae) strains. in Archives of Insect Biochemistry and Physiology. 2022;109(3):e21866.
doi:10.1002/arch.21866 .
Pavković‐Lučić, Sofija, Trajković, Jelena, Miličić, Dragana, Anđelković, Boban D., Lučić, Luka, Savić, Tatjana, Vujisić, Ljubodrag V., "“Scent of a fruit fly”: Cuticular chemoprofilesafter mating in differently fedDrosophilamelanogaster(Diptera: Drosophilidae) strains" in Archives of Insect Biochemistry and Physiology, 109, no. 3 (2022):e21866,
https://doi.org/10.1002/arch.21866 . .
4

Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens

Nikolić, Biljana M.; Milanović, Slobodan D.; Milenković, Ivan Lj.; Todosijević, Marina; Đorđević, Iris Ž.; Brkić, Milana Z.; Mitić, Zorica S.; Marin, Petar D.; Tešević, Vele

(Elsevier, 2022)

TY  - JOUR
AU  - Nikolić, Biljana M.
AU  - Milanović, Slobodan D.
AU  - Milenković, Ivan Lj.
AU  - Todosijević, Marina
AU  - Đorđević, Iris Ž.
AU  - Brkić, Milana Z.
AU  - Mitić, Zorica S.
AU  - Marin, Petar D.
AU  - Tešević, Vele
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4885
AB  - We examined essential oils (EOs) of Chamaecyparis lawsoniana and Thuja plicata (Cupressaceae), their antifeedant activity on Lymanthria dispar larvae and their antimicrobial activity. Studies of EOs showed that these two conifer species differed both in content of terpene classes and the major compounds. Total monoterpenes strongly dominated in T. plicata (96.4%), while C. lawsoniana was rich in both mono- and sesquiterpenes (40.8% and 30.3%, respectively) as well as in diterpenes (19.1%). The most dominant compounds of C. lawsoniana EO were: limonene (16.7%), oplopanonyl acetate (14.5%), beyerene (10.1%), and 13-epi-dolabradiene (6.7%). The dominant compound of T. plicata EOs was α-thujone (76.9%), followed by relatively small amounts of β- thujone (5.3%), sabinene (4.5%) and terpinene-4-ol (3.2%). The difference in EO compositions of the conifers was reflected on Lymantria dispar larvae performance. Larvae fed on the leaf discs treated by C. lawsoniana EO had a slight phagostimulatory effect at lower concentration shown by higher relative rate of food consumption and relative growth rate than the larvae in the control group. Contrastingly, leaf discs treated with EO of T. plicata EO had an antifeedant effect and lower relative consumption rate (RCR) and relative growth rate RGR than the larvae in the control group. Both tested EOs influenced substantially the colony growth of the subjected Phytophthora plurivora and P. quercina. Namely, 100% inhibitory effect was recorded at concentration of 0.1% in the case of C. lawsoniana EO, whereas of T. plicata colonies did not grow at 0.5% concentration. The implications of these findings and possibility of using the tested EOs in further experiments in vitro and in vivo are discussed.
PB  - Elsevier
T2  - Industrial Crops and Products
T2  - Industrial Crops and ProductsIndustrial Crops and Products
T1  - Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens
VL  - 178
SP  - 114550
DO  - 10.1016/j.indcrop.2022.114550
ER  - 
@article{
author = "Nikolić, Biljana M. and Milanović, Slobodan D. and Milenković, Ivan Lj. and Todosijević, Marina and Đorđević, Iris Ž. and Brkić, Milana Z. and Mitić, Zorica S. and Marin, Petar D. and Tešević, Vele",
year = "2022",
abstract = "We examined essential oils (EOs) of Chamaecyparis lawsoniana and Thuja plicata (Cupressaceae), their antifeedant activity on Lymanthria dispar larvae and their antimicrobial activity. Studies of EOs showed that these two conifer species differed both in content of terpene classes and the major compounds. Total monoterpenes strongly dominated in T. plicata (96.4%), while C. lawsoniana was rich in both mono- and sesquiterpenes (40.8% and 30.3%, respectively) as well as in diterpenes (19.1%). The most dominant compounds of C. lawsoniana EO were: limonene (16.7%), oplopanonyl acetate (14.5%), beyerene (10.1%), and 13-epi-dolabradiene (6.7%). The dominant compound of T. plicata EOs was α-thujone (76.9%), followed by relatively small amounts of β- thujone (5.3%), sabinene (4.5%) and terpinene-4-ol (3.2%). The difference in EO compositions of the conifers was reflected on Lymantria dispar larvae performance. Larvae fed on the leaf discs treated by C. lawsoniana EO had a slight phagostimulatory effect at lower concentration shown by higher relative rate of food consumption and relative growth rate than the larvae in the control group. Contrastingly, leaf discs treated with EO of T. plicata EO had an antifeedant effect and lower relative consumption rate (RCR) and relative growth rate RGR than the larvae in the control group. Both tested EOs influenced substantially the colony growth of the subjected Phytophthora plurivora and P. quercina. Namely, 100% inhibitory effect was recorded at concentration of 0.1% in the case of C. lawsoniana EO, whereas of T. plicata colonies did not grow at 0.5% concentration. The implications of these findings and possibility of using the tested EOs in further experiments in vitro and in vivo are discussed.",
publisher = "Elsevier",
journal = "Industrial Crops and Products, Industrial Crops and ProductsIndustrial Crops and Products",
title = "Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens",
volume = "178",
pages = "114550",
doi = "10.1016/j.indcrop.2022.114550"
}
Nikolić, B. M., Milanović, S. D., Milenković, I. Lj., Todosijević, M., Đorđević, I. Ž., Brkić, M. Z., Mitić, Z. S., Marin, P. D.,& Tešević, V.. (2022). Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens. in Industrial Crops and Products
Elsevier., 178, 114550.
https://doi.org/10.1016/j.indcrop.2022.114550
Nikolić BM, Milanović SD, Milenković IL, Todosijević M, Đorđević IŽ, Brkić MZ, Mitić ZS, Marin PD, Tešević V. Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens. in Industrial Crops and Products. 2022;178:114550.
doi:10.1016/j.indcrop.2022.114550 .
Nikolić, Biljana M., Milanović, Slobodan D., Milenković, Ivan Lj., Todosijević, Marina, Đorđević, Iris Ž., Brkić, Milana Z., Mitić, Zorica S., Marin, Petar D., Tešević, Vele, "Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens" in Industrial Crops and Products, 178 (2022):114550,
https://doi.org/10.1016/j.indcrop.2022.114550 . .

Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity

Vesović, Nikola; Nenadić, Marija; Soković, Marina; Ćirić, Ana; Vujisić, Ljubodrag V.; Todosijević, Marina; Stevanović, Nataša; Perić-Mataruga, Vesna; Ilijin, Larisa; Ćurčić, Srećko

(SpringerLink, 2022)

TY  - JOUR
AU  - Vesović, Nikola
AU  - Nenadić, Marija
AU  - Soković, Marina
AU  - Ćirić, Ana
AU  - Vujisić, Ljubodrag V.
AU  - Todosijević, Marina
AU  - Stevanović, Nataša
AU  - Perić-Mataruga, Vesna
AU  - Ilijin, Larisa
AU  - Ćurčić, Srećko
PY  - 2022
UR  - https://doi.org/10.1007/s00114-022-01790-0
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5183
AB  - Pygidial gland secretions are used as repellent defensive allomones in ground beetles. We provide the first precise data on the chemical composition and antimicrobial potency of the secretion of the blue ground beetle, as well as on the morphology of its pygidial glands. The latter structures were not previously studied chemoecologically and morphologically, and we hypothesized that their secretion may have some antimicrobial action, as is the case with certain Carabus species. Gas chromatography-mass spectrometry (GC-MS) was used to identify methacrylic and angelic acids as dominant chemicals in the secretion from individuals of three populations of the blue ground beetle in Serbia. We tested its secretion against selected strains of medically important microorganisms. The secretion exibits antimicrobial action against certain bacterial species and all tested micromycetes. The most significant antifungal effect of the secretion was against Penicillium ochrochloron, which is more sensitive to the secretion than to commercial antifungal drugs ketoconazole and bifonazole. Bifonazole achieved minimum inhibitory concentrations against Trichoderma viride at more than three times higher value than did the secretion, indicating a significant antifungal effect of the secretion against this micromycete as well. Additionally, we tested commercially available standards of two dominant chemicals in the secretion to investigate their interaction and antimicrobial role in the secretion. Finally, we describe all glandular morpho-functional units of the blue ground beetle. Our results suggest that the secretion of the blue ground beetle may serve not only defensive but also antimicrobial functions, which likely aid the survival of this beetle in the microbial-rich forest litter habitat.
PB  - SpringerLink
T2  - The Science of Nature
T1  - Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity
VL  - 109
IS  - 2
SP  - 19
DO  - 10.1007/s00114-022-01790-0
ER  - 
@article{
author = "Vesović, Nikola and Nenadić, Marija and Soković, Marina and Ćirić, Ana and Vujisić, Ljubodrag V. and Todosijević, Marina and Stevanović, Nataša and Perić-Mataruga, Vesna and Ilijin, Larisa and Ćurčić, Srećko",
year = "2022",
abstract = "Pygidial gland secretions are used as repellent defensive allomones in ground beetles. We provide the first precise data on the chemical composition and antimicrobial potency of the secretion of the blue ground beetle, as well as on the morphology of its pygidial glands. The latter structures were not previously studied chemoecologically and morphologically, and we hypothesized that their secretion may have some antimicrobial action, as is the case with certain Carabus species. Gas chromatography-mass spectrometry (GC-MS) was used to identify methacrylic and angelic acids as dominant chemicals in the secretion from individuals of three populations of the blue ground beetle in Serbia. We tested its secretion against selected strains of medically important microorganisms. The secretion exibits antimicrobial action against certain bacterial species and all tested micromycetes. The most significant antifungal effect of the secretion was against Penicillium ochrochloron, which is more sensitive to the secretion than to commercial antifungal drugs ketoconazole and bifonazole. Bifonazole achieved minimum inhibitory concentrations against Trichoderma viride at more than three times higher value than did the secretion, indicating a significant antifungal effect of the secretion against this micromycete as well. Additionally, we tested commercially available standards of two dominant chemicals in the secretion to investigate their interaction and antimicrobial role in the secretion. Finally, we describe all glandular morpho-functional units of the blue ground beetle. Our results suggest that the secretion of the blue ground beetle may serve not only defensive but also antimicrobial functions, which likely aid the survival of this beetle in the microbial-rich forest litter habitat.",
publisher = "SpringerLink",
journal = "The Science of Nature",
title = "Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity",
volume = "109",
number = "2",
pages = "19",
doi = "10.1007/s00114-022-01790-0"
}
Vesović, N., Nenadić, M., Soković, M., Ćirić, A., Vujisić, L. V., Todosijević, M., Stevanović, N., Perić-Mataruga, V., Ilijin, L.,& Ćurčić, S.. (2022). Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity. in The Science of Nature
SpringerLink., 109(2), 19.
https://doi.org/10.1007/s00114-022-01790-0
Vesović N, Nenadić M, Soković M, Ćirić A, Vujisić LV, Todosijević M, Stevanović N, Perić-Mataruga V, Ilijin L, Ćurčić S. Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity. in The Science of Nature. 2022;109(2):19.
doi:10.1007/s00114-022-01790-0 .
Vesović, Nikola, Nenadić, Marija, Soković, Marina, Ćirić, Ana, Vujisić, Ljubodrag V., Todosijević, Marina, Stevanović, Nataša, Perić-Mataruga, Vesna, Ilijin, Larisa, Ćurčić, Srećko, "Pygidial glands of the blue ground beetle Carabus intricatus: chemical composition of the secretion and its antimicrobial activity" in The Science of Nature, 109, no. 2 (2022):19,
https://doi.org/10.1007/s00114-022-01790-0 . .

Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents

Hicke, Francisco J.; Puerta, Adrián; Dinić, Jelena; Pešić, Milica; Padrón, José M.; López, Óscar; Fernández-Bolaños, José G.

(Elsevier, 2022)

TY  - JOUR
AU  - Hicke, Francisco J.
AU  - Puerta, Adrián
AU  - Dinić, Jelena
AU  - Pešić, Milica
AU  - Padrón, José M.
AU  - López, Óscar
AU  - Fernández-Bolaños, José G.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4869
AB  - The necessity for developing novel cytostatic agents with improved activities and reduced side-effects to tackle cancer prompted us to investigate mitochondria-targeted compounds, an approach that is gaining attention for the selective transportation of cytotoxic agents. We envisioned the possibility of conjugating a phenethyl alcohol motif, decorated with a series of phenol-based substituents on the aryl moiety, with a triphenyl phosphonium scaffold (a mitochondria-directed vector), through a hydrocarbon chain of different lengths. Thus, such compounds that incorporate the phenethyl skeleton can be considered as masked phenolic compounds derived from relevant natural counterparts found in olive tree (e.g. tyrosol, hydroxytyrosol). Title compounds exhibited very strong in vitro antiproliferative activities against the panel of six human tumor cell lines tested, with GI50 values ranging from the nanomolar (0.026 ± 0.010 μM for 36) to the submicromolar range in most of the cases; this represents an improvement of up to 350-fold compared to classical chemotherapeutic agents, like 5-fluorouracil or cisplatin. Interestingly, decrease in the linker length led to an increase of GI50 values against non-tumor cells, thus allowing a remarkable improvement of selectivity (SI up to 269). The very promising antiproliferative activities prompted us to further investigate their behaviour against multidrug resistant cell lines (MDR). The results indicated a reduced sensitivity of the multidrug resistant cells to compounds, probably due to P-gp-mediated efflux of these antiproliferative agents. Interestingly, activities were completely restored to the same levels by co-administration of tariquidar, a well-known inhibitor of P-gp. Flow cytometry analysis on sensitive cell lines revealed a decrease in the percentage of cells in G1 phase accompanied by increase in S and G2/M phases. In addition, a significant increase in subG1 area, was observed. These results are compatible with the necrotic and apoptotic cell death detected in the Annexin V assay, and with the depolarization of the mitochondria membrane. Thus, the new mitochondriotropic agents reported herein can be considered as promising antiproliferative agents, endowed with remarkable potency and selectivity, including MDR cells, upon co-administration with a pump-efflux inhibitor.
PB  - Elsevier
T2  - European Journal of Medicinal Chemistry
T1  - Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents
VL  - 228
SP  - 113980
DO  - 10.1016/j.ejmech.2021.113980
ER  - 
@article{
author = "Hicke, Francisco J. and Puerta, Adrián and Dinić, Jelena and Pešić, Milica and Padrón, José M. and López, Óscar and Fernández-Bolaños, José G.",
year = "2022",
abstract = "The necessity for developing novel cytostatic agents with improved activities and reduced side-effects to tackle cancer prompted us to investigate mitochondria-targeted compounds, an approach that is gaining attention for the selective transportation of cytotoxic agents. We envisioned the possibility of conjugating a phenethyl alcohol motif, decorated with a series of phenol-based substituents on the aryl moiety, with a triphenyl phosphonium scaffold (a mitochondria-directed vector), through a hydrocarbon chain of different lengths. Thus, such compounds that incorporate the phenethyl skeleton can be considered as masked phenolic compounds derived from relevant natural counterparts found in olive tree (e.g. tyrosol, hydroxytyrosol). Title compounds exhibited very strong in vitro antiproliferative activities against the panel of six human tumor cell lines tested, with GI50 values ranging from the nanomolar (0.026 ± 0.010 μM for 36) to the submicromolar range in most of the cases; this represents an improvement of up to 350-fold compared to classical chemotherapeutic agents, like 5-fluorouracil or cisplatin. Interestingly, decrease in the linker length led to an increase of GI50 values against non-tumor cells, thus allowing a remarkable improvement of selectivity (SI up to 269). The very promising antiproliferative activities prompted us to further investigate their behaviour against multidrug resistant cell lines (MDR). The results indicated a reduced sensitivity of the multidrug resistant cells to compounds, probably due to P-gp-mediated efflux of these antiproliferative agents. Interestingly, activities were completely restored to the same levels by co-administration of tariquidar, a well-known inhibitor of P-gp. Flow cytometry analysis on sensitive cell lines revealed a decrease in the percentage of cells in G1 phase accompanied by increase in S and G2/M phases. In addition, a significant increase in subG1 area, was observed. These results are compatible with the necrotic and apoptotic cell death detected in the Annexin V assay, and with the depolarization of the mitochondria membrane. Thus, the new mitochondriotropic agents reported herein can be considered as promising antiproliferative agents, endowed with remarkable potency and selectivity, including MDR cells, upon co-administration with a pump-efflux inhibitor.",
publisher = "Elsevier",
journal = "European Journal of Medicinal Chemistry",
title = "Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents",
volume = "228",
pages = "113980",
doi = "10.1016/j.ejmech.2021.113980"
}
Hicke, F. J., Puerta, A., Dinić, J., Pešić, M., Padrón, J. M., López, Ó.,& Fernández-Bolaños, J. G.. (2022). Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents. in European Journal of Medicinal Chemistry
Elsevier., 228, 113980.
https://doi.org/10.1016/j.ejmech.2021.113980
Hicke FJ, Puerta A, Dinić J, Pešić M, Padrón JM, López Ó, Fernández-Bolaños JG. Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents. in European Journal of Medicinal Chemistry. 2022;228:113980.
doi:10.1016/j.ejmech.2021.113980 .
Hicke, Francisco J., Puerta, Adrián, Dinić, Jelena, Pešić, Milica, Padrón, José M., López, Óscar, Fernández-Bolaños, José G., "Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents" in European Journal of Medicinal Chemistry, 228 (2022):113980,
https://doi.org/10.1016/j.ejmech.2021.113980 . .
12

Supplementary data for article: Hicke, F. J.; Puerta, A.; Dinić, J.; Pešić, M.; Padrón, J. M.; López, Ó.; Fernández-Bolaños, J. G. Straightforward Access to Novel Mitochondriotropics Derived from 2-Arylethanol as Potent and Selective Antiproliferative Agents. European Journal of Medicinal Chemistry 2022, 228, 113980. https://doi.org/10.1016/j.ejmech.2021.113980.

Hicke, Francisco J.; Puerta, Adrián; Dinić, Jelena; Pešić, Milica; Padrón, José M.; López, Óscar; Fernández-Bolaños, José G.

(Elsevier, 2022)

TY  - DATA
AU  - Hicke, Francisco J.
AU  - Puerta, Adrián
AU  - Dinić, Jelena
AU  - Pešić, Milica
AU  - Padrón, José M.
AU  - López, Óscar
AU  - Fernández-Bolaños, José G.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4870
PB  - Elsevier
T2  - European Journal of Medicinal Chemistry
T1  - Supplementary data for article: Hicke, F. J.; Puerta, A.; Dinić, J.; Pešić, M.; Padrón, J. M.; López, Ó.; Fernández-Bolaños, J. G. Straightforward Access to Novel Mitochondriotropics Derived from 2-Arylethanol as Potent and Selective Antiproliferative Agents. European Journal of Medicinal Chemistry 2022, 228, 113980. https://doi.org/10.1016/j.ejmech.2021.113980.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4870
ER  - 
@misc{
author = "Hicke, Francisco J. and Puerta, Adrián and Dinić, Jelena and Pešić, Milica and Padrón, José M. and López, Óscar and Fernández-Bolaños, José G.",
year = "2022",
publisher = "Elsevier",
journal = "European Journal of Medicinal Chemistry",
title = "Supplementary data for article: Hicke, F. J.; Puerta, A.; Dinić, J.; Pešić, M.; Padrón, J. M.; López, Ó.; Fernández-Bolaños, J. G. Straightforward Access to Novel Mitochondriotropics Derived from 2-Arylethanol as Potent and Selective Antiproliferative Agents. European Journal of Medicinal Chemistry 2022, 228, 113980. https://doi.org/10.1016/j.ejmech.2021.113980.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4870"
}
Hicke, F. J., Puerta, A., Dinić, J., Pešić, M., Padrón, J. M., López, Ó.,& Fernández-Bolaños, J. G.. (2022). Supplementary data for article: Hicke, F. J.; Puerta, A.; Dinić, J.; Pešić, M.; Padrón, J. M.; López, Ó.; Fernández-Bolaños, J. G. Straightforward Access to Novel Mitochondriotropics Derived from 2-Arylethanol as Potent and Selective Antiproliferative Agents. European Journal of Medicinal Chemistry 2022, 228, 113980. https://doi.org/10.1016/j.ejmech.2021.113980.. in European Journal of Medicinal Chemistry
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4870
Hicke FJ, Puerta A, Dinić J, Pešić M, Padrón JM, López Ó, Fernández-Bolaños JG. Supplementary data for article: Hicke, F. J.; Puerta, A.; Dinić, J.; Pešić, M.; Padrón, J. M.; López, Ó.; Fernández-Bolaños, J. G. Straightforward Access to Novel Mitochondriotropics Derived from 2-Arylethanol as Potent and Selective Antiproliferative Agents. European Journal of Medicinal Chemistry 2022, 228, 113980. https://doi.org/10.1016/j.ejmech.2021.113980.. in European Journal of Medicinal Chemistry. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_4870 .
Hicke, Francisco J., Puerta, Adrián, Dinić, Jelena, Pešić, Milica, Padrón, José M., López, Óscar, Fernández-Bolaños, José G., "Supplementary data for article: Hicke, F. J.; Puerta, A.; Dinić, J.; Pešić, M.; Padrón, J. M.; López, Ó.; Fernández-Bolaños, J. G. Straightforward Access to Novel Mitochondriotropics Derived from 2-Arylethanol as Potent and Selective Antiproliferative Agents. European Journal of Medicinal Chemistry 2022, 228, 113980. https://doi.org/10.1016/j.ejmech.2021.113980." in European Journal of Medicinal Chemistry (2022),
https://hdl.handle.net/21.15107/rcub_cherry_4870 .

Elemental Analysis and Phenolic Profiles of Selected Italian Wines

Fermo, Paola; Comite, Valeria; Sredojević, Milica; Ćirić, Ivanka; Gašić, Uroš M.; Mutić, Jelena; Baošić, Rada; Tešić, Živoslav Lj.

(MDPI, 2021)

TY  - JOUR
AU  - Fermo, Paola
AU  - Comite, Valeria
AU  - Sredojević, Milica
AU  - Ćirić, Ivanka
AU  - Gašić, Uroš M.
AU  - Mutić, Jelena
AU  - Baošić, Rada
AU  - Tešić, Živoslav Lj.
PY  - 2021
AB  - The study of the chemical composition of wines is nowadays a topic of great interest because of the importance of this market, especially in Italy, and also considering the numerous cases of falsification of famous and very expensive wines. The present paper focused on the analysis of metals and polyphenols in Italian wines belonging to different provenance and types. At this purpose 20 elements were quantified by inductively coupled plasma optical emission spectrometry (ICP-OES) and ICP mass spectrometry (ICP-MS). Regarding polyphenols, a total of 32 were quantified, among 6 were anthocyanins. Furthermore, in 4 samples (1 rosè and 3 red wines) 42 anthocyanins and related compounds were identified by ultra-high performance liquid chromatography (UHPLC)-Orbitrap MS technique (among these, 6 were also quantified). Non-anthocyanins were determined using UHPLC coupled with a diode array detector and triple-quadrupole mass spectrometer (UHPLC–DAD-QqQ-MS). Total phenolic content (TPC) and radical scavenging activity (RSA) were measured using spectrophotometric methods. The results obtained by elemental techniques were submitted to principal components analysis (PCA) allowing to get information on both geographical and botanical origin of the examined wine samples. Some polyphenols have been detected in higher concentrations only in a certain type of wine, as for example in the case of Grechetto wine. Most of the identified anthocyanin derivatives (pyranoanthocyanins) are formed during the aging of wine by reaction with the other wine components.
PB  - MDPI
T2  - Foods
T1  - Elemental Analysis and Phenolic Profiles of Selected Italian Wines
VL  - 10
IS  - 1
SP  - 158
DO  - 10.3390/foods10010158
ER  - 
@article{
author = "Fermo, Paola and Comite, Valeria and Sredojević, Milica and Ćirić, Ivanka and Gašić, Uroš M. and Mutić, Jelena and Baošić, Rada and Tešić, Živoslav Lj.",
year = "2021",
abstract = "The study of the chemical composition of wines is nowadays a topic of great interest because of the importance of this market, especially in Italy, and also considering the numerous cases of falsification of famous and very expensive wines. The present paper focused on the analysis of metals and polyphenols in Italian wines belonging to different provenance and types. At this purpose 20 elements were quantified by inductively coupled plasma optical emission spectrometry (ICP-OES) and ICP mass spectrometry (ICP-MS). Regarding polyphenols, a total of 32 were quantified, among 6 were anthocyanins. Furthermore, in 4 samples (1 rosè and 3 red wines) 42 anthocyanins and related compounds were identified by ultra-high performance liquid chromatography (UHPLC)-Orbitrap MS technique (among these, 6 were also quantified). Non-anthocyanins were determined using UHPLC coupled with a diode array detector and triple-quadrupole mass spectrometer (UHPLC–DAD-QqQ-MS). Total phenolic content (TPC) and radical scavenging activity (RSA) were measured using spectrophotometric methods. The results obtained by elemental techniques were submitted to principal components analysis (PCA) allowing to get information on both geographical and botanical origin of the examined wine samples. Some polyphenols have been detected in higher concentrations only in a certain type of wine, as for example in the case of Grechetto wine. Most of the identified anthocyanin derivatives (pyranoanthocyanins) are formed during the aging of wine by reaction with the other wine components.",
publisher = "MDPI",
journal = "Foods",
title = "Elemental Analysis and Phenolic Profiles of Selected Italian Wines",
volume = "10",
number = "1",
pages = "158",
doi = "10.3390/foods10010158"
}
Fermo, P., Comite, V., Sredojević, M., Ćirić, I., Gašić, U. M., Mutić, J., Baošić, R.,& Tešić, Ž. Lj.. (2021). Elemental Analysis and Phenolic Profiles of Selected Italian Wines. in Foods
MDPI., 10(1), 158.
https://doi.org/10.3390/foods10010158
Fermo P, Comite V, Sredojević M, Ćirić I, Gašić UM, Mutić J, Baošić R, Tešić ŽL. Elemental Analysis and Phenolic Profiles of Selected Italian Wines. in Foods. 2021;10(1):158.
doi:10.3390/foods10010158 .
Fermo, Paola, Comite, Valeria, Sredojević, Milica, Ćirić, Ivanka, Gašić, Uroš M., Mutić, Jelena, Baošić, Rada, Tešić, Živoslav Lj., "Elemental Analysis and Phenolic Profiles of Selected Italian Wines" in Foods, 10, no. 1 (2021):158,
https://doi.org/10.3390/foods10010158 . .
5
3
4

Supplementary data for the article: Fermo, P.; Comite, V.; Sredojević, M.; Ćirić, I.; Gašić, U.; Mutić, J.; Baošić, R.; Tešić, Ž. Elemental Analysis and Phenolic Profiles of Selected Italian Wines. Foods 2021, 10 (1), 158. https://doi.org/10.3390/foods10010158.

Fermo, Paola; Comite, Valeria; Sredojević, Milica; Ćirić, Ivanka; Gašić, Uroš M.; Mutić, Jelena; Baošić, Rada; Tešić, Živoslav Lj.

(MDPI, 2021)

TY  - DATA
AU  - Fermo, Paola
AU  - Comite, Valeria
AU  - Sredojević, Milica
AU  - Ćirić, Ivanka
AU  - Gašić, Uroš M.
AU  - Mutić, Jelena
AU  - Baošić, Rada
AU  - Tešić, Živoslav Lj.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4811
PB  - MDPI
T2  - Foods
T1  - Supplementary data for the article: Fermo, P.; Comite, V.; Sredojević, M.; Ćirić, I.; Gašić, U.; Mutić, J.; Baošić, R.; Tešić, Ž. Elemental Analysis and Phenolic Profiles of Selected Italian Wines. Foods 2021, 10 (1), 158. https://doi.org/10.3390/foods10010158.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4811
ER  - 
@misc{
author = "Fermo, Paola and Comite, Valeria and Sredojević, Milica and Ćirić, Ivanka and Gašić, Uroš M. and Mutić, Jelena and Baošić, Rada and Tešić, Živoslav Lj.",
year = "2021",
publisher = "MDPI",
journal = "Foods",
title = "Supplementary data for the article: Fermo, P.; Comite, V.; Sredojević, M.; Ćirić, I.; Gašić, U.; Mutić, J.; Baošić, R.; Tešić, Ž. Elemental Analysis and Phenolic Profiles of Selected Italian Wines. Foods 2021, 10 (1), 158. https://doi.org/10.3390/foods10010158.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4811"
}
Fermo, P., Comite, V., Sredojević, M., Ćirić, I., Gašić, U. M., Mutić, J., Baošić, R.,& Tešić, Ž. Lj.. (2021). Supplementary data for the article: Fermo, P.; Comite, V.; Sredojević, M.; Ćirić, I.; Gašić, U.; Mutić, J.; Baošić, R.; Tešić, Ž. Elemental Analysis and Phenolic Profiles of Selected Italian Wines. Foods 2021, 10 (1), 158. https://doi.org/10.3390/foods10010158.. in Foods
MDPI..
https://hdl.handle.net/21.15107/rcub_cherry_4811
Fermo P, Comite V, Sredojević M, Ćirić I, Gašić UM, Mutić J, Baošić R, Tešić ŽL. Supplementary data for the article: Fermo, P.; Comite, V.; Sredojević, M.; Ćirić, I.; Gašić, U.; Mutić, J.; Baošić, R.; Tešić, Ž. Elemental Analysis and Phenolic Profiles of Selected Italian Wines. Foods 2021, 10 (1), 158. https://doi.org/10.3390/foods10010158.. in Foods. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4811 .
Fermo, Paola, Comite, Valeria, Sredojević, Milica, Ćirić, Ivanka, Gašić, Uroš M., Mutić, Jelena, Baošić, Rada, Tešić, Živoslav Lj., "Supplementary data for the article: Fermo, P.; Comite, V.; Sredojević, M.; Ćirić, I.; Gašić, U.; Mutić, J.; Baošić, R.; Tešić, Ž. Elemental Analysis and Phenolic Profiles of Selected Italian Wines. Foods 2021, 10 (1), 158. https://doi.org/10.3390/foods10010158." in Foods (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4811 .

Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus unedo L.) Leaves and Fruits

Brčić-Karačonji, Irena; Jurica, Karlo; Gašić, Uroš M.; Dramićanin, Aleksandra M.; Tešić, Živoslav Lj.; Milojković-Opsenica, Dušanka

(MDPI, 2021)

TY  - JOUR
AU  - Brčić-Karačonji, Irena
AU  - Jurica, Karlo
AU  - Gašić, Uroš M.
AU  - Dramićanin, Aleksandra M.
AU  - Tešić, Živoslav Lj.
AU  - Milojković-Opsenica, Dušanka
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5014
AB  - The strawberry tree (Arbutus unedo L., Ericaceae family) is an evergreen Mediterranean
shrub whose leaves and fruits are used in traditional medicine due to their antioxidant, antimicrobial,
antidiabetic, diuretic, and antiproliferative properties. The health benefits are mainly attributed to the
presence of phenolic compounds. The aim of this study was to compare the phenolic profiles, total
phenolic content (TPC), and radical scavenging activity (RSA) of A. unedo leaves and fruits collected
at two locations in Croatia. Phenolic profiles were identified using an ultra-high-performance liquid
chromatograph (UHPLC) coupled with a hybrid mass spectrometer (LTQ Orbitrap MS). TPC was
determined by Folin–Ciocalteu’s assay, while RSA was investigated using DPPH reagent. A total of
64 phenolics (60 and 42 compounds in leaves and fruits, respectively) were identified. Hyperoside
and flavan-3-ols were predominant compounds in leaves, while gallocatechin and catechin were
the major compounds found in fruits. To the authors’ knowledge, 16 and 5 phenolics in leaves and
fruits, respectively, were reported for the first time. Principal component analysis (PCA) showed
that UHPLC-LTQ Orbitrap MS could be used to identify which phenolics were able to discriminate
samples regarding plant tissue and geographical origin. TPC in leaves and fruits were in the ranges of
67.07–104.74 and 16.78–25.86 mg gallic acid equivalents (GAE)/g dried weight (dw), respectively. RSA
for leaves and fruits were in the ranges of 408.92–430.98 and 74.30–104.04 µmol Trolox equivalents
(TE)/g dw, respectively. The number of identified phenolics was lower in fruits compared to leaves.
Such a large number of bioactive phenolics identified and the strong antioxidant activity pointed to
A. unedo as a promising health-promoting plant and natural food preservative.
PB  - MDPI
T2  - Plants
T1  - Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus unedo L.) Leaves and Fruits
VL  - 11
IS  - 25
DO  - 10.3390/plants11010025
ER  - 
@article{
author = "Brčić-Karačonji, Irena and Jurica, Karlo and Gašić, Uroš M. and Dramićanin, Aleksandra M. and Tešić, Živoslav Lj. and Milojković-Opsenica, Dušanka",
year = "2021",
abstract = "The strawberry tree (Arbutus unedo L., Ericaceae family) is an evergreen Mediterranean
shrub whose leaves and fruits are used in traditional medicine due to their antioxidant, antimicrobial,
antidiabetic, diuretic, and antiproliferative properties. The health benefits are mainly attributed to the
presence of phenolic compounds. The aim of this study was to compare the phenolic profiles, total
phenolic content (TPC), and radical scavenging activity (RSA) of A. unedo leaves and fruits collected
at two locations in Croatia. Phenolic profiles were identified using an ultra-high-performance liquid
chromatograph (UHPLC) coupled with a hybrid mass spectrometer (LTQ Orbitrap MS). TPC was
determined by Folin–Ciocalteu’s assay, while RSA was investigated using DPPH reagent. A total of
64 phenolics (60 and 42 compounds in leaves and fruits, respectively) were identified. Hyperoside
and flavan-3-ols were predominant compounds in leaves, while gallocatechin and catechin were
the major compounds found in fruits. To the authors’ knowledge, 16 and 5 phenolics in leaves and
fruits, respectively, were reported for the first time. Principal component analysis (PCA) showed
that UHPLC-LTQ Orbitrap MS could be used to identify which phenolics were able to discriminate
samples regarding plant tissue and geographical origin. TPC in leaves and fruits were in the ranges of
67.07–104.74 and 16.78–25.86 mg gallic acid equivalents (GAE)/g dried weight (dw), respectively. RSA
for leaves and fruits were in the ranges of 408.92–430.98 and 74.30–104.04 µmol Trolox equivalents
(TE)/g dw, respectively. The number of identified phenolics was lower in fruits compared to leaves.
Such a large number of bioactive phenolics identified and the strong antioxidant activity pointed to
A. unedo as a promising health-promoting plant and natural food preservative.",
publisher = "MDPI",
journal = "Plants",
title = "Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus unedo L.) Leaves and Fruits",
volume = "11",
number = "25",
doi = "10.3390/plants11010025"
}
Brčić-Karačonji, I., Jurica, K., Gašić, U. M., Dramićanin, A. M., Tešić, Ž. Lj.,& Milojković-Opsenica, D.. (2021). Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus unedo L.) Leaves and Fruits. in Plants
MDPI., 11(25).
https://doi.org/10.3390/plants11010025
Brčić-Karačonji I, Jurica K, Gašić UM, Dramićanin AM, Tešić ŽL, Milojković-Opsenica D. Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus unedo L.) Leaves and Fruits. in Plants. 2021;11(25).
doi:10.3390/plants11010025 .
Brčić-Karačonji, Irena, Jurica, Karlo, Gašić, Uroš M., Dramićanin, Aleksandra M., Tešić, Živoslav Lj., Milojković-Opsenica, Dušanka, "Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus unedo L.) Leaves and Fruits" in Plants, 11, no. 25 (2021),
https://doi.org/10.3390/plants11010025 . .
1

Supplementary data for the article: Brčić-Karačonji, I.; Jurica, K.; Gašić, U. M.; Dramićanin, A. M.; Tešić, Ž. L.; Milojković-Opsenica, D. Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus Unedo L.) Leaves and Fruits. Plants 2021, 11 (25). https://doi.org/10.3390/plants11010025.

Brčić-Karačonji, Irena; Jurica, Karlo; Gašić, Uroš M.; Dramićanin, Aleksandra M.; Tešić, Živoslav Lj.; Milojković-Opsenica, Dušanka

(MDPI, 2021)

TY  - DATA
AU  - Brčić-Karačonji, Irena
AU  - Jurica, Karlo
AU  - Gašić, Uroš M.
AU  - Dramićanin, Aleksandra M.
AU  - Tešić, Živoslav Lj.
AU  - Milojković-Opsenica, Dušanka
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5017
PB  - MDPI
T2  - Plants
T1  - Supplementary data for the article: Brčić-Karačonji, I.; Jurica, K.; Gašić, U. M.; Dramićanin, A. M.; Tešić, Ž. L.; Milojković-Opsenica, D. Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus Unedo L.) Leaves and Fruits. Plants 2021, 11 (25). https://doi.org/10.3390/plants11010025.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5017
ER  - 
@misc{
author = "Brčić-Karačonji, Irena and Jurica, Karlo and Gašić, Uroš M. and Dramićanin, Aleksandra M. and Tešić, Živoslav Lj. and Milojković-Opsenica, Dušanka",
year = "2021",
publisher = "MDPI",
journal = "Plants",
title = "Supplementary data for the article: Brčić-Karačonji, I.; Jurica, K.; Gašić, U. M.; Dramićanin, A. M.; Tešić, Ž. L.; Milojković-Opsenica, D. Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus Unedo L.) Leaves and Fruits. Plants 2021, 11 (25). https://doi.org/10.3390/plants11010025.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5017"
}
Brčić-Karačonji, I., Jurica, K., Gašić, U. M., Dramićanin, A. M., Tešić, Ž. Lj.,& Milojković-Opsenica, D.. (2021). Supplementary data for the article: Brčić-Karačonji, I.; Jurica, K.; Gašić, U. M.; Dramićanin, A. M.; Tešić, Ž. L.; Milojković-Opsenica, D. Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus Unedo L.) Leaves and Fruits. Plants 2021, 11 (25). https://doi.org/10.3390/plants11010025.. in Plants
MDPI..
https://hdl.handle.net/21.15107/rcub_cherry_5017
Brčić-Karačonji I, Jurica K, Gašić UM, Dramićanin AM, Tešić ŽL, Milojković-Opsenica D. Supplementary data for the article: Brčić-Karačonji, I.; Jurica, K.; Gašić, U. M.; Dramićanin, A. M.; Tešić, Ž. L.; Milojković-Opsenica, D. Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus Unedo L.) Leaves and Fruits. Plants 2021, 11 (25). https://doi.org/10.3390/plants11010025.. in Plants. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_5017 .
Brčić-Karačonji, Irena, Jurica, Karlo, Gašić, Uroš M., Dramićanin, Aleksandra M., Tešić, Živoslav Lj., Milojković-Opsenica, Dušanka, "Supplementary data for the article: Brčić-Karačonji, I.; Jurica, K.; Gašić, U. M.; Dramićanin, A. M.; Tešić, Ž. L.; Milojković-Opsenica, D. Comparative Study on the Phenolic Fingerprint and Antioxidant Activity of Strawberry Tree (Arbutus Unedo L.) Leaves and Fruits. Plants 2021, 11 (25). https://doi.org/10.3390/plants11010025." in Plants (2021),
https://hdl.handle.net/21.15107/rcub_cherry_5017 .

Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph, Larvae, Pupae, Honey, Wax, Propolis and Bee Bread

Ilijević, Konstantin; Vujanović, D.; Zarić, N. M.; Orlić, Jovana; Orčić, S.; Purać, J.; Kojić, D.; Blagojević, D. P.; Čelić, T.

(Belgrade : Serbian Chemical Society, 2021)

TY  - CONF
AU  - Ilijević, Konstantin
AU  - Vujanović, D.
AU  - Zarić, N. M.
AU  - Orlić, Jovana
AU  - Orčić, S.
AU  - Purać, J.
AU  - Kojić, D.
AU  - Blagojević, D. P.
AU  - Čelić, T.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4911
AB  - In our previous research we have explored concentrations of 16 elements in samples collected from 3 different environments: Golija (rural region), Belgrade (urban region) and Zajača (industrial region). These three locations were chosen due to their distinctly different degrees of urbanization and industrialization. Macroelements (Ca, K, Mg, Na), microelements (Cu, Fe, Mn, Zn) and non-essential elements (Al, Ba, Cd, Co, Cr, Ni, Pb, Sr) were determined in the whole body of honeybees, but the major novelty of the research was that hemolymph of the bees was analysed as well. Significant spatial but also seasonal variations in content of bioelements and non-essential elements were observed. These findings have raised several important questions which are addressed in our current study. In order to better understand how bees’ environment does affects concentrations of elements mentioned above, dust and pollen collected from the same locations were analysed. They represent 2 major sources of bio elements and toxic elements for the bees: food and atmospheric deposition. For the better understanding of dynamics of investigated elements the scope of our research was further extended to the analysis of bee bread, honey, crops, wax, propolis, larvae and pupae. The samples were digested in accordance with the US EPA SW-846 Method 3052. Closed microwave digestion system (ETHOS 1, Advanced Microwave Digestion System, Milestone, Italy) was used for digestion with 5 to 8 ml of concentrated HNO3  and 1 or 2 ml of concentrated H2 O2  (depending on the mass and type of the sample). Concentrations of: Al, Ba, Cd, Co, Cr, Cu, Ca, Fe, K, Mg, Mn, Na, Ni, Pb, Sr and Zn were determined by ICP-OES (iCAP 6500Duo, Thermo Scientific). Very low concentrations of: Co, Cr, Cd and Pb, which occurred in some samples were confirmed by ICP-MS (iCAP-Q-ICP-MS, Termo Scientific). Ratios between concentrations in the samples from industrial region and urban region were calculated and compared for different matrices. Concentrations of toxic metals such as Pb and Cd were significantly elevated in dust samples from the industrial site, and similar trend was observed for pollen, bee bread, wax, propolis, and the whole bees. Elevation of concentrations was not observed (or it was present in significantly lesser extent) for the samples of honey, larvae and pupae.
PB  - Belgrade : Serbian Chemical Society
C3  - Book of Abstracts 21st; European Meeting on Environmental Chemistry
T1  - Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph, Larvae, Pupae, Honey, Wax, Propolis and Bee Bread
SP  - 81
EP  - 81
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4911
ER  - 
@conference{
author = "Ilijević, Konstantin and Vujanović, D. and Zarić, N. M. and Orlić, Jovana and Orčić, S. and Purać, J. and Kojić, D. and Blagojević, D. P. and Čelić, T.",
year = "2021",
abstract = "In our previous research we have explored concentrations of 16 elements in samples collected from 3 different environments: Golija (rural region), Belgrade (urban region) and Zajača (industrial region). These three locations were chosen due to their distinctly different degrees of urbanization and industrialization. Macroelements (Ca, K, Mg, Na), microelements (Cu, Fe, Mn, Zn) and non-essential elements (Al, Ba, Cd, Co, Cr, Ni, Pb, Sr) were determined in the whole body of honeybees, but the major novelty of the research was that hemolymph of the bees was analysed as well. Significant spatial but also seasonal variations in content of bioelements and non-essential elements were observed. These findings have raised several important questions which are addressed in our current study. In order to better understand how bees’ environment does affects concentrations of elements mentioned above, dust and pollen collected from the same locations were analysed. They represent 2 major sources of bio elements and toxic elements for the bees: food and atmospheric deposition. For the better understanding of dynamics of investigated elements the scope of our research was further extended to the analysis of bee bread, honey, crops, wax, propolis, larvae and pupae. The samples were digested in accordance with the US EPA SW-846 Method 3052. Closed microwave digestion system (ETHOS 1, Advanced Microwave Digestion System, Milestone, Italy) was used for digestion with 5 to 8 ml of concentrated HNO3  and 1 or 2 ml of concentrated H2 O2  (depending on the mass and type of the sample). Concentrations of: Al, Ba, Cd, Co, Cr, Cu, Ca, Fe, K, Mg, Mn, Na, Ni, Pb, Sr and Zn were determined by ICP-OES (iCAP 6500Duo, Thermo Scientific). Very low concentrations of: Co, Cr, Cd and Pb, which occurred in some samples were confirmed by ICP-MS (iCAP-Q-ICP-MS, Termo Scientific). Ratios between concentrations in the samples from industrial region and urban region were calculated and compared for different matrices. Concentrations of toxic metals such as Pb and Cd were significantly elevated in dust samples from the industrial site, and similar trend was observed for pollen, bee bread, wax, propolis, and the whole bees. Elevation of concentrations was not observed (or it was present in significantly lesser extent) for the samples of honey, larvae and pupae.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Book of Abstracts 21st; European Meeting on Environmental Chemistry",
title = "Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph, Larvae, Pupae, Honey, Wax, Propolis and Bee Bread",
pages = "81-81",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4911"
}
Ilijević, K., Vujanović, D., Zarić, N. M., Orlić, J., Orčić, S., Purać, J., Kojić, D., Blagojević, D. P.,& Čelić, T.. (2021). Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph, Larvae, Pupae, Honey, Wax, Propolis and Bee Bread. in Book of Abstracts 21st; European Meeting on Environmental Chemistry
Belgrade : Serbian Chemical Society., 81-81.
https://hdl.handle.net/21.15107/rcub_cherry_4911
Ilijević K, Vujanović D, Zarić NM, Orlić J, Orčić S, Purać J, Kojić D, Blagojević DP, Čelić T. Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph, Larvae, Pupae, Honey, Wax, Propolis and Bee Bread. in Book of Abstracts 21st; European Meeting on Environmental Chemistry. 2021;:81-81.
https://hdl.handle.net/21.15107/rcub_cherry_4911 .
Ilijević, Konstantin, Vujanović, D., Zarić, N. M., Orlić, Jovana, Orčić, S., Purać, J., Kojić, D., Blagojević, D. P., Čelić, T., "Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph, Larvae, Pupae, Honey, Wax, Propolis and Bee Bread" in Book of Abstracts 21st; European Meeting on Environmental Chemistry (2021):81-81,
https://hdl.handle.net/21.15107/rcub_cherry_4911 .

Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph

Ilijević, Konstantin; Vujanović, Dragana; Orčić, Snežana; Purać, Jelena; Kojić, Danijela; Zarić, Nenad M.; Gržetić, Ivan; Blagojević, Duško P.; Čelić, Tatjana V.

(Elsevier Inc., 2021)

TY  - JOUR
AU  - Ilijević, Konstantin
AU  - Vujanović, Dragana
AU  - Orčić, Snežana
AU  - Purać, Jelena
AU  - Kojić, Danijela
AU  - Zarić, Nenad M.
AU  - Gržetić, Ivan
AU  - Blagojević, Duško P.
AU  - Čelić, Tatjana V.
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4616
AB  - Honeybee colony losses have been a focus of research in the last years, due to the importance of managed honeybee colonies for economy and ecology. Different unfavorable conditions from the outside environment have a strong impact on the hive health. The majority of losses occur mainly during winter and the exact reason is not completely understood. Only a small number of studies are dealing with content of bioelements, their function and influence on honeybee physiology. The aim of the present study was to determine seasonal and spatial variations in content of bioelements and non-essential elements, in hemolymph and whole body of honeybees originating from three regions with different degrees of urbanization and industrialization. Concentrations of 16 elements were compared: macroelements (Ca, K, Mg, Na), microelements (Cu, Fe, Mn, Zn) and non-essential elements (Al, Ba, Cd, Co, Cr, Ni, Pb, Sr) in samples collected from 3 different environments: Golija (rural region), Belgrade (urban region) and Zajača (industrial region). Content of bioelements and non-essential elements in honeybees was under noticeable influence of the surrounding environment, season and degree of honeybee activity. Hemolymph was proven to be helpful in differentiating air pollution from other sources of honeybee exposure. The results of our study demonstrated that bees can be successfully used as biomonitors since we have observed statistically significant differences among observed locations, but unless compared locations are exposed to excessively different pollution pressures, it is essential that all bees should be collected at the same season.
PB  - Elsevier Inc.
T2  - Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
T1  - Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph
VL  - 239
SP  - 108852
DO  - 10.1016/j.cbpc.2020.108852
ER  - 
@article{
author = "Ilijević, Konstantin and Vujanović, Dragana and Orčić, Snežana and Purać, Jelena and Kojić, Danijela and Zarić, Nenad M. and Gržetić, Ivan and Blagojević, Duško P. and Čelić, Tatjana V.",
year = "2021",
abstract = "Honeybee colony losses have been a focus of research in the last years, due to the importance of managed honeybee colonies for economy and ecology. Different unfavorable conditions from the outside environment have a strong impact on the hive health. The majority of losses occur mainly during winter and the exact reason is not completely understood. Only a small number of studies are dealing with content of bioelements, their function and influence on honeybee physiology. The aim of the present study was to determine seasonal and spatial variations in content of bioelements and non-essential elements, in hemolymph and whole body of honeybees originating from three regions with different degrees of urbanization and industrialization. Concentrations of 16 elements were compared: macroelements (Ca, K, Mg, Na), microelements (Cu, Fe, Mn, Zn) and non-essential elements (Al, Ba, Cd, Co, Cr, Ni, Pb, Sr) in samples collected from 3 different environments: Golija (rural region), Belgrade (urban region) and Zajača (industrial region). Content of bioelements and non-essential elements in honeybees was under noticeable influence of the surrounding environment, season and degree of honeybee activity. Hemolymph was proven to be helpful in differentiating air pollution from other sources of honeybee exposure. The results of our study demonstrated that bees can be successfully used as biomonitors since we have observed statistically significant differences among observed locations, but unless compared locations are exposed to excessively different pollution pressures, it is essential that all bees should be collected at the same season.",
publisher = "Elsevier Inc.",
journal = "Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology",
title = "Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph",
volume = "239",
pages = "108852",
doi = "10.1016/j.cbpc.2020.108852"
}
Ilijević, K., Vujanović, D., Orčić, S., Purać, J., Kojić, D., Zarić, N. M., Gržetić, I., Blagojević, D. P.,& Čelić, T. V.. (2021). Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph. in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
Elsevier Inc.., 239, 108852.
https://doi.org/10.1016/j.cbpc.2020.108852
Ilijević K, Vujanović D, Orčić S, Purać J, Kojić D, Zarić NM, Gržetić I, Blagojević DP, Čelić TV. Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph. in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 2021;239:108852.
doi:10.1016/j.cbpc.2020.108852 .
Ilijević, Konstantin, Vujanović, Dragana, Orčić, Snežana, Purać, Jelena, Kojić, Danijela, Zarić, Nenad M., Gržetić, Ivan, Blagojević, Duško P., Čelić, Tatjana V., "Anthropogenic influence on seasonal and spatial variation in bioelements and non-essential elements in honeybees and their hemolymph" in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 239 (2021):108852,
https://doi.org/10.1016/j.cbpc.2020.108852 . .
5
2
4

Supplementary data for the article: Ilijević, K.; Vujanović, D.; Orčić, S.; Purać, J.; Kojić, D.; Zarić, N.; Gržetić, I.; Blagojević, D. P.; Čelić, T. V. Anthropogenic Influence on Seasonal and Spatial Variation in Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2021, 239, 108852. https://doi.org/10.1016/j.cbpc.2020.108852.

Ilijević, Konstantin; Vujanović, Dragana; Orčić, Snežana; Purać, Jelena; Kojić, Danijela; Zarić, Nenad M.; Gržetić, Ivan; Blagojević, Duško P.; Čelić, Tatjana V.

(Elsevier Inc., 2021)

TY  - DATA
AU  - Ilijević, Konstantin
AU  - Vujanović, Dragana
AU  - Orčić, Snežana
AU  - Purać, Jelena
AU  - Kojić, Danijela
AU  - Zarić, Nenad M.
AU  - Gržetić, Ivan
AU  - Blagojević, Duško P.
AU  - Čelić, Tatjana V.
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4617
PB  - Elsevier Inc.
T2  - Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
T1  - Supplementary data for the article: Ilijević, K.; Vujanović, D.; Orčić, S.; Purać, J.; Kojić, D.; Zarić, N.; Gržetić, I.; Blagojević, D. P.; Čelić, T. V. Anthropogenic Influence on Seasonal and Spatial Variation in Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2021, 239, 108852. https://doi.org/10.1016/j.cbpc.2020.108852.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4617
ER  - 
@misc{
author = "Ilijević, Konstantin and Vujanović, Dragana and Orčić, Snežana and Purać, Jelena and Kojić, Danijela and Zarić, Nenad M. and Gržetić, Ivan and Blagojević, Duško P. and Čelić, Tatjana V.",
year = "2021",
publisher = "Elsevier Inc.",
journal = "Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology",
title = "Supplementary data for the article: Ilijević, K.; Vujanović, D.; Orčić, S.; Purać, J.; Kojić, D.; Zarić, N.; Gržetić, I.; Blagojević, D. P.; Čelić, T. V. Anthropogenic Influence on Seasonal and Spatial Variation in Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2021, 239, 108852. https://doi.org/10.1016/j.cbpc.2020.108852.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4617"
}
Ilijević, K., Vujanović, D., Orčić, S., Purać, J., Kojić, D., Zarić, N. M., Gržetić, I., Blagojević, D. P.,& Čelić, T. V.. (2021). Supplementary data for the article: Ilijević, K.; Vujanović, D.; Orčić, S.; Purać, J.; Kojić, D.; Zarić, N.; Gržetić, I.; Blagojević, D. P.; Čelić, T. V. Anthropogenic Influence on Seasonal and Spatial Variation in Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2021, 239, 108852. https://doi.org/10.1016/j.cbpc.2020.108852.. in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
Elsevier Inc...
https://hdl.handle.net/21.15107/rcub_cherry_4617
Ilijević K, Vujanović D, Orčić S, Purać J, Kojić D, Zarić NM, Gržetić I, Blagojević DP, Čelić TV. Supplementary data for the article: Ilijević, K.; Vujanović, D.; Orčić, S.; Purać, J.; Kojić, D.; Zarić, N.; Gržetić, I.; Blagojević, D. P.; Čelić, T. V. Anthropogenic Influence on Seasonal and Spatial Variation in Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2021, 239, 108852. https://doi.org/10.1016/j.cbpc.2020.108852.. in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4617 .
Ilijević, Konstantin, Vujanović, Dragana, Orčić, Snežana, Purać, Jelena, Kojić, Danijela, Zarić, Nenad M., Gržetić, Ivan, Blagojević, Duško P., Čelić, Tatjana V., "Supplementary data for the article: Ilijević, K.; Vujanović, D.; Orčić, S.; Purać, J.; Kojić, D.; Zarić, N.; Gržetić, I.; Blagojević, D. P.; Čelić, T. V. Anthropogenic Influence on Seasonal and Spatial Variation in Bioelements and Non-Essential Elements in Honeybees and Their Hemolymph. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2021, 239, 108852. https://doi.org/10.1016/j.cbpc.2020.108852." in Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4617 .
2
4

Autochthonous and international grape varieties grown in Serbia - Phenolic and elemental composition

Natić, Maja; Dabić-Zagorac, Dragana; Gašić, Uroš M.; Dojčinović, Biljana P.; Ćirić, Ivanka; Relić, Dubravka; Todić, Slavica; Sredojević, Milica

(Elsevier, 2021)

TY  - JOUR
AU  - Natić, Maja
AU  - Dabić-Zagorac, Dragana
AU  - Gašić, Uroš M.
AU  - Dojčinović, Biljana P.
AU  - Ćirić, Ivanka
AU  - Relić, Dubravka
AU  - Todić, Slavica
AU  - Sredojević, Milica
PY  - 2021
UR  - https://www.sciencedirect.com/science/article/pii/S2212429221000146
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4487
AB  - The phenolic and elemental profiles of Serbian autochthonous grape varieties ‘Smederevka’ and ‘Plovdina’ were studied and compared with some international varieties. Total phenolic content and radical scavenging activity were highest in seeds of ‘Plovdina’, and in ‘Smederevka’ skins, which also had the highest contents of ferulic, chlorogenic and caffeic acids (16.0, 1.44 and 0.98 mg/kg, respectively). Protocatechuic acid was quantified only in the seeds of these varieties. Untypically for Vitis vinifera L. species, the presence of malvidin 3,5-O-dihexoside was found in the skins of ‘Vranac’ and ‘Muscat Hamburg’. In ‘Plovdina’ skins among the anthocyanins, hexosides of peonidin and delphinidin were prevalent. ‘Plovdina’ grapes had lower quantities of Al, Ni and Na in comparison to the other varieties intended for white wine production. Significant correlations among the most abundant elements, such as K, P, Ca, Mg, S, Fe, Cu, and Zn, pointed to potential positive interactions. For elements that have toxicological reference values, the health risk assessment was calculated for adults and children, and suggested that all samples were safe for human consumption.
PB  - Elsevier
T2  - Food Bioscience
T2  - Food BioscienceFood Bioscience
T1  - Autochthonous and international grape varieties grown in Serbia - Phenolic and elemental composition
VL  - 40
SP  - 100889
DO  - 10.1016/j.fbio.2021.100889
ER  - 
@article{
author = "Natić, Maja and Dabić-Zagorac, Dragana and Gašić, Uroš M. and Dojčinović, Biljana P. and Ćirić, Ivanka and Relić, Dubravka and Todić, Slavica and Sredojević, Milica",
year = "2021",
abstract = "The phenolic and elemental profiles of Serbian autochthonous grape varieties ‘Smederevka’ and ‘Plovdina’ were studied and compared with some international varieties. Total phenolic content and radical scavenging activity were highest in seeds of ‘Plovdina’, and in ‘Smederevka’ skins, which also had the highest contents of ferulic, chlorogenic and caffeic acids (16.0, 1.44 and 0.98 mg/kg, respectively). Protocatechuic acid was quantified only in the seeds of these varieties. Untypically for Vitis vinifera L. species, the presence of malvidin 3,5-O-dihexoside was found in the skins of ‘Vranac’ and ‘Muscat Hamburg’. In ‘Plovdina’ skins among the anthocyanins, hexosides of peonidin and delphinidin were prevalent. ‘Plovdina’ grapes had lower quantities of Al, Ni and Na in comparison to the other varieties intended for white wine production. Significant correlations among the most abundant elements, such as K, P, Ca, Mg, S, Fe, Cu, and Zn, pointed to potential positive interactions. For elements that have toxicological reference values, the health risk assessment was calculated for adults and children, and suggested that all samples were safe for human consumption.",
publisher = "Elsevier",
journal = "Food Bioscience, Food BioscienceFood Bioscience",
title = "Autochthonous and international grape varieties grown in Serbia - Phenolic and elemental composition",
volume = "40",
pages = "100889",
doi = "10.1016/j.fbio.2021.100889"
}
Natić, M., Dabić-Zagorac, D., Gašić, U. M., Dojčinović, B. P., Ćirić, I., Relić, D., Todić, S.,& Sredojević, M.. (2021). Autochthonous and international grape varieties grown in Serbia - Phenolic and elemental composition. in Food Bioscience
Elsevier., 40, 100889.
https://doi.org/10.1016/j.fbio.2021.100889
Natić M, Dabić-Zagorac D, Gašić UM, Dojčinović BP, Ćirić I, Relić D, Todić S, Sredojević M. Autochthonous and international grape varieties grown in Serbia - Phenolic and elemental composition. in Food Bioscience. 2021;40:100889.
doi:10.1016/j.fbio.2021.100889 .
Natić, Maja, Dabić-Zagorac, Dragana, Gašić, Uroš M., Dojčinović, Biljana P., Ćirić, Ivanka, Relić, Dubravka, Todić, Slavica, Sredojević, Milica, "Autochthonous and international grape varieties grown in Serbia - Phenolic and elemental composition" in Food Bioscience, 40 (2021):100889,
https://doi.org/10.1016/j.fbio.2021.100889 . .
1

Supplementary data for the article: Natić, M.; Dabić Zagorac, D.; Gašić, U.; Dojčinović, B.; Ćirić, I.; Relić, D.; Todić, S.; Sredojević, M. Autochthonous and International Grape Varieties Grown in Serbia - Phenolic and Elemental Composition. Food Bioscience 2021, 40, 100889. https://doi.org/10.1016/j.fbio.2021.100889.

Natić, Maja; Dabić-Zagorac, Dragana; Gašić, Uroš M.; Dojčinović, Biljana P.; Ćirić, Ivanka; Relić, Dubravka; Todić, Slavica; Sredojević, Milica

(Elsevier, 2021)

TY  - DATA
AU  - Natić, Maja
AU  - Dabić-Zagorac, Dragana
AU  - Gašić, Uroš M.
AU  - Dojčinović, Biljana P.
AU  - Ćirić, Ivanka
AU  - Relić, Dubravka
AU  - Todić, Slavica
AU  - Sredojević, Milica
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4487
UR  - https://www.sciencedirect.com/science/article/pii/S2212429221000146
PB  - Elsevier
T2  - Food Bioscience
T2  - Food BioscienceFood Bioscience
T1  - Supplementary data for the article: Natić, M.; Dabić Zagorac, D.; Gašić, U.; Dojčinović, B.; Ćirić, I.; Relić, D.; Todić, S.; Sredojević, M. Autochthonous and International Grape Varieties Grown in Serbia - Phenolic and Elemental Composition. Food Bioscience 2021, 40, 100889. https://doi.org/10.1016/j.fbio.2021.100889.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4488
ER  - 
@misc{
author = "Natić, Maja and Dabić-Zagorac, Dragana and Gašić, Uroš M. and Dojčinović, Biljana P. and Ćirić, Ivanka and Relić, Dubravka and Todić, Slavica and Sredojević, Milica",
year = "2021",
publisher = "Elsevier",
journal = "Food Bioscience, Food BioscienceFood Bioscience",
title = "Supplementary data for the article: Natić, M.; Dabić Zagorac, D.; Gašić, U.; Dojčinović, B.; Ćirić, I.; Relić, D.; Todić, S.; Sredojević, M. Autochthonous and International Grape Varieties Grown in Serbia - Phenolic and Elemental Composition. Food Bioscience 2021, 40, 100889. https://doi.org/10.1016/j.fbio.2021.100889.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4488"
}
Natić, M., Dabić-Zagorac, D., Gašić, U. M., Dojčinović, B. P., Ćirić, I., Relić, D., Todić, S.,& Sredojević, M.. (2021). Supplementary data for the article: Natić, M.; Dabić Zagorac, D.; Gašić, U.; Dojčinović, B.; Ćirić, I.; Relić, D.; Todić, S.; Sredojević, M. Autochthonous and International Grape Varieties Grown in Serbia - Phenolic and Elemental Composition. Food Bioscience 2021, 40, 100889. https://doi.org/10.1016/j.fbio.2021.100889.. in Food Bioscience
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4488
Natić M, Dabić-Zagorac D, Gašić UM, Dojčinović BP, Ćirić I, Relić D, Todić S, Sredojević M. Supplementary data for the article: Natić, M.; Dabić Zagorac, D.; Gašić, U.; Dojčinović, B.; Ćirić, I.; Relić, D.; Todić, S.; Sredojević, M. Autochthonous and International Grape Varieties Grown in Serbia - Phenolic and Elemental Composition. Food Bioscience 2021, 40, 100889. https://doi.org/10.1016/j.fbio.2021.100889.. in Food Bioscience. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4488 .
Natić, Maja, Dabić-Zagorac, Dragana, Gašić, Uroš M., Dojčinović, Biljana P., Ćirić, Ivanka, Relić, Dubravka, Todić, Slavica, Sredojević, Milica, "Supplementary data for the article: Natić, M.; Dabić Zagorac, D.; Gašić, U.; Dojčinović, B.; Ćirić, I.; Relić, D.; Todić, S.; Sredojević, M. Autochthonous and International Grape Varieties Grown in Serbia - Phenolic and Elemental Composition. Food Bioscience 2021, 40, 100889. https://doi.org/10.1016/j.fbio.2021.100889." in Food Bioscience (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4488 .

The effects of meldonium on the acute ischemia/reperfusion liver injury in rats

Đurašević, Siniša; Stojković, Maja; Sopta, Jelena; Pavlović, Slađan Z.; Borković-Mitić, Slavica S.; Ivanović, Anđelija; Jasnić, Nebojša; Tosti, Tomislav; Đurović, Saša; Đorđević, Jelena; Todorović, Zoran B.

(Springer Nature, 2021)

TY  - JOUR
AU  - Đurašević, Siniša
AU  - Stojković, Maja
AU  - Sopta, Jelena
AU  - Pavlović, Slađan Z.
AU  - Borković-Mitić, Slavica S.
AU  - Ivanović, Anđelija
AU  - Jasnić, Nebojša
AU  - Tosti, Tomislav
AU  - Đurović, Saša
AU  - Đorđević, Jelena
AU  - Todorović, Zoran B.
PY  - 2021
UR  - https://www.nature.com/articles/s41598-020-80011-y
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4458
AB  - Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures.
PB  - Springer Nature
T2  - Scientific Reports
T2  - Scientific ReportsSci Rep
T1  - The effects of meldonium on the acute ischemia/reperfusion liver injury in rats
VL  - 11
IS  - 1
SP  - 1305
DO  - 10.1038/s41598-020-80011-y
ER  - 
@article{
author = "Đurašević, Siniša and Stojković, Maja and Sopta, Jelena and Pavlović, Slađan Z. and Borković-Mitić, Slavica S. and Ivanović, Anđelija and Jasnić, Nebojša and Tosti, Tomislav and Đurović, Saša and Đorđević, Jelena and Todorović, Zoran B.",
year = "2021",
abstract = "Acute ischemia/reperfusion (I/R) liver injury is a clinical condition challenging to treat. Meldonium is an anti-ischemic agent that shifts energy production from fatty acid oxidation to less oxygen-consuming glycolysis. Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. Our results showed that meldonium ameliorates I/R-induced liver inflammation and injury, as confirmed by liver histology, and by attenuation of serum alanine- and aspartate aminotransferase activity, serum and liver high mobility group box 1 protein expression, and liver expression of Bax/Bcl2, haptoglobin, and the phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells. Through the increased hepatic activation of the nuclear factor erythroid 2-related factor 2, meldonium improves the antioxidative defence in the liver of animals subjected to I/R, as proved by an increase in serum and liver ascorbic/dehydroascorbic acid ratio, hepatic haem oxygenase 1 expression, glutathione and free thiol groups content, and hepatic copper-zinc superoxide dismutase, manganese superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver injury, with a clinical significance in surgical procedures.",
publisher = "Springer Nature",
journal = "Scientific Reports, Scientific ReportsSci Rep",
title = "The effects of meldonium on the acute ischemia/reperfusion liver injury in rats",
volume = "11",
number = "1",
pages = "1305",
doi = "10.1038/s41598-020-80011-y"
}
Đurašević, S., Stojković, M., Sopta, J., Pavlović, S. Z., Borković-Mitić, S. S., Ivanović, A., Jasnić, N., Tosti, T., Đurović, S., Đorđević, J.,& Todorović, Z. B.. (2021). The effects of meldonium on the acute ischemia/reperfusion liver injury in rats. in Scientific Reports
Springer Nature., 11(1), 1305.
https://doi.org/10.1038/s41598-020-80011-y
Đurašević S, Stojković M, Sopta J, Pavlović SZ, Borković-Mitić SS, Ivanović A, Jasnić N, Tosti T, Đurović S, Đorđević J, Todorović ZB. The effects of meldonium on the acute ischemia/reperfusion liver injury in rats. in Scientific Reports. 2021;11(1):1305.
doi:10.1038/s41598-020-80011-y .
Đurašević, Siniša, Stojković, Maja, Sopta, Jelena, Pavlović, Slađan Z., Borković-Mitić, Slavica S., Ivanović, Anđelija, Jasnić, Nebojša, Tosti, Tomislav, Đurović, Saša, Đorđević, Jelena, Todorović, Zoran B., "The effects of meldonium on the acute ischemia/reperfusion liver injury in rats" in Scientific Reports, 11, no. 1 (2021):1305,
https://doi.org/10.1038/s41598-020-80011-y . .
1
5
5
5

Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y.

Đurašević, Siniša; Stojković, Maja; Sopta, Jelena; Pavlović, Slađan Z.; Borković-Mitić, Slavica S.; Ivanović, Anđelija; Jasnić, Nebojša; Tosti, Tomislav; Đurović, Saša; Đorđević, Jelena; Todorović, Zoran B.

(Springer Nature, 2021)

TY  - DATA
AU  - Đurašević, Siniša
AU  - Stojković, Maja
AU  - Sopta, Jelena
AU  - Pavlović, Slađan Z.
AU  - Borković-Mitić, Slavica S.
AU  - Ivanović, Anđelija
AU  - Jasnić, Nebojša
AU  - Tosti, Tomislav
AU  - Đurović, Saša
AU  - Đorđević, Jelena
AU  - Todorović, Zoran B.
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4459
PB  - Springer Nature
T2  - Scientific Reports
T1  - Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4459
ER  - 
@misc{
author = "Đurašević, Siniša and Stojković, Maja and Sopta, Jelena and Pavlović, Slađan Z. and Borković-Mitić, Slavica S. and Ivanović, Anđelija and Jasnić, Nebojša and Tosti, Tomislav and Đurović, Saša and Đorđević, Jelena and Todorović, Zoran B.",
year = "2021",
publisher = "Springer Nature",
journal = "Scientific Reports",
title = "Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4459"
}
Đurašević, S., Stojković, M., Sopta, J., Pavlović, S. Z., Borković-Mitić, S. S., Ivanović, A., Jasnić, N., Tosti, T., Đurović, S., Đorđević, J.,& Todorović, Z. B.. (2021). Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y.. in Scientific Reports
Springer Nature..
https://hdl.handle.net/21.15107/rcub_cherry_4459
Đurašević S, Stojković M, Sopta J, Pavlović SZ, Borković-Mitić SS, Ivanović A, Jasnić N, Tosti T, Đurović S, Đorđević J, Todorović ZB. Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y.. in Scientific Reports. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4459 .
Đurašević, Siniša, Stojković, Maja, Sopta, Jelena, Pavlović, Slađan Z., Borković-Mitić, Slavica S., Ivanović, Anđelija, Jasnić, Nebojša, Tosti, Tomislav, Đurović, Saša, Đorđević, Jelena, Todorović, Zoran B., "Supplementary data for the article: Đurašević, S.; Stojković, M.; Sopta, J.; Pavlović, S.; Borković-Mitić, S.; Ivanović, A.; Jasnić, N.; Tosti, T.; Đurović, S.; Đorđević, J.; Todorović, Z. The Effects of Meldonium on the Acute Ischemia/Reperfusion Liver Injury in Rats. Sci Rep 2021, 11 (1), 1305. https://doi.org/10.1038/s41598-020-80011-y." in Scientific Reports (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4459 .

Lipidomics provides new insight into pathogenesis and therapeutic targets of the ischemia—reperfusion injury

Todorović, Zoran B.; Đurašević, Siniša; Stojković, Maja; Grigorov, Ilijana; Pavlović, Slađan Z.; Jasnić, Nebojša; Tosti, Tomislav; Macut Bjekić, Jelica; Thiemermann, Christoph; Đorđević, Jelena

(MDPI, 2021)

TY  - JOUR
AU  - Todorović, Zoran B.
AU  - Đurašević, Siniša
AU  - Stojković, Maja
AU  - Grigorov, Ilijana
AU  - Pavlović, Slađan Z.
AU  - Jasnić, Nebojša
AU  - Tosti, Tomislav
AU  - Macut Bjekić, Jelica
AU  - Thiemermann, Christoph
AU  - Đorđević, Jelena
PY  - 2021
UR  - https://www.mdpi.com/1422-0067/22/6/2798
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4512
AB  - Lipids play an essential role in both tissue protection and damage. Tissue ischemia creates anaerobic conditions in which enzyme inactivation occurs, and reperfusion can initiate oxidative stress that leads to harmful changes in membrane lipids, the formation of aldehydes, and chain damage until cell death. The critical event in such a series of harmful events in the cell is the unwanted accumulation of fatty acids that leads to lipotoxicity. Lipid analysis provides additional insight into the pathogenesis of ischemia/reperfusion (I/R) disorders and reveals new targets for drug action. The profile of changes in the composition of fatty acids in the cell, as well as the time course of these changes, indicate both the mechanism of damage and new therapeutic possibilities. A therapeutic approach to reperfusion lipotoxicity involves attenuation of fatty acids overload, i.e., their transport to adipose tissue and/or inhibition of the adverse effects of fatty acids on cell damage and death. The latter option involves using PPAR agonists and drugs that modulate the transport of fatty acids via carnitine into the interior of the mitochondria or the redirection of long-chain fatty acids to peroxisomes.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T2  - International Journal of Molecular Sciences
T1  - Lipidomics provides new insight into pathogenesis and therapeutic targets of the ischemia—reperfusion injury
VL  - 22
IS  - 6
SP  - 2798
DO  - 10.3390/ijms22062798
ER  - 
@article{
author = "Todorović, Zoran B. and Đurašević, Siniša and Stojković, Maja and Grigorov, Ilijana and Pavlović, Slađan Z. and Jasnić, Nebojša and Tosti, Tomislav and Macut Bjekić, Jelica and Thiemermann, Christoph and Đorđević, Jelena",
year = "2021",
abstract = "Lipids play an essential role in both tissue protection and damage. Tissue ischemia creates anaerobic conditions in which enzyme inactivation occurs, and reperfusion can initiate oxidative stress that leads to harmful changes in membrane lipids, the formation of aldehydes, and chain damage until cell death. The critical event in such a series of harmful events in the cell is the unwanted accumulation of fatty acids that leads to lipotoxicity. Lipid analysis provides additional insight into the pathogenesis of ischemia/reperfusion (I/R) disorders and reveals new targets for drug action. The profile of changes in the composition of fatty acids in the cell, as well as the time course of these changes, indicate both the mechanism of damage and new therapeutic possibilities. A therapeutic approach to reperfusion lipotoxicity involves attenuation of fatty acids overload, i.e., their transport to adipose tissue and/or inhibition of the adverse effects of fatty acids on cell damage and death. The latter option involves using PPAR agonists and drugs that modulate the transport of fatty acids via carnitine into the interior of the mitochondria or the redirection of long-chain fatty acids to peroxisomes.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences, International Journal of Molecular Sciences",
title = "Lipidomics provides new insight into pathogenesis and therapeutic targets of the ischemia—reperfusion injury",
volume = "22",
number = "6",
pages = "2798",
doi = "10.3390/ijms22062798"
}
Todorović, Z. B., Đurašević, S., Stojković, M., Grigorov, I., Pavlović, S. Z., Jasnić, N., Tosti, T., Macut Bjekić, J., Thiemermann, C.,& Đorđević, J.. (2021). Lipidomics provides new insight into pathogenesis and therapeutic targets of the ischemia—reperfusion injury. in International Journal of Molecular Sciences
MDPI., 22(6), 2798.
https://doi.org/10.3390/ijms22062798
Todorović ZB, Đurašević S, Stojković M, Grigorov I, Pavlović SZ, Jasnić N, Tosti T, Macut Bjekić J, Thiemermann C, Đorđević J. Lipidomics provides new insight into pathogenesis and therapeutic targets of the ischemia—reperfusion injury. in International Journal of Molecular Sciences. 2021;22(6):2798.
doi:10.3390/ijms22062798 .
Todorović, Zoran B., Đurašević, Siniša, Stojković, Maja, Grigorov, Ilijana, Pavlović, Slađan Z., Jasnić, Nebojša, Tosti, Tomislav, Macut Bjekić, Jelica, Thiemermann, Christoph, Đorđević, Jelena, "Lipidomics provides new insight into pathogenesis and therapeutic targets of the ischemia—reperfusion injury" in International Journal of Molecular Sciences, 22, no. 6 (2021):2798,
https://doi.org/10.3390/ijms22062798 . .
3
1
3

The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats

Đurašević, Siniša; Ružičić, Aleksandra; Lakić, Iva; Tosti, Tomislav; Đurović, Saša; Glumac, Sofija; Pavlović, Slađan Z.; Borković-Mitić, Slavica S.; Grigorov, Ilijana; Stanković, Sanja; Jasnić, Nebojša; Đorđević, Jelena; Todorović, Zoran B.

(MDPI, 2021)

TY  - JOUR
AU  - Đurašević, Siniša
AU  - Ružičić, Aleksandra
AU  - Lakić, Iva
AU  - Tosti, Tomislav
AU  - Đurović, Saša
AU  - Glumac, Sofija
AU  - Pavlović, Slađan Z.
AU  - Borković-Mitić, Slavica S.
AU  - Grigorov, Ilijana
AU  - Stanković, Sanja
AU  - Jasnić, Nebojša
AU  - Đorđević, Jelena
AU  - Todorović, Zoran B.
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4671
AB  - Sepsis is a life-threatening condition caused by the dysregulated and overwhelming response to infection, accompanied by an exaggerated pro-inflammatory state and lipid metabolism disturbance leading to sequential organ failure. Meldonium is an anti-ischemic and anti-inflammatory agent which negatively interferes with lipid metabolism by shifting energy production from fatty acid oxidation to glycolysis, as a less oxygen-demanding pathway. Thus, we investigated the effects of a four-week meldonium pre-treatment on faecal-induced sepsis in Sprague-Dawley male rats. Surprisingly, under septic conditions, meldonium increased animal mortality rate compared with the meldonium non-treated group. However, analysis of the tissue oxidative status did not provide support for the detrimental effects of meldonium, nor did the analysis of the tissue inflammatory status showing anti-inflammatory, anti-apoptotic, and anti-necrotic effects of meldonium. After performing tissue lipidomic analysis, we concluded that the potential cause of the meldonium harmful effect is to be found in the overall decreased lipid metabolism. The present study underlines the importance of uninterrupted energy production in sepsis, closely drawing attention to the possible harmful effects of lipid-mobilization impairment caused by certain therapeutics. This could lead to the much-needed revision of the existing guidelines in the clinical treatment of sepsis while paving the way for discovering new therapeutic approaches.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats
VL  - 22
IS  - 18
SP  - 9698
DO  - 10.3390/ijms22189698
ER  - 
@article{
author = "Đurašević, Siniša and Ružičić, Aleksandra and Lakić, Iva and Tosti, Tomislav and Đurović, Saša and Glumac, Sofija and Pavlović, Slađan Z. and Borković-Mitić, Slavica S. and Grigorov, Ilijana and Stanković, Sanja and Jasnić, Nebojša and Đorđević, Jelena and Todorović, Zoran B.",
year = "2021",
abstract = "Sepsis is a life-threatening condition caused by the dysregulated and overwhelming response to infection, accompanied by an exaggerated pro-inflammatory state and lipid metabolism disturbance leading to sequential organ failure. Meldonium is an anti-ischemic and anti-inflammatory agent which negatively interferes with lipid metabolism by shifting energy production from fatty acid oxidation to glycolysis, as a less oxygen-demanding pathway. Thus, we investigated the effects of a four-week meldonium pre-treatment on faecal-induced sepsis in Sprague-Dawley male rats. Surprisingly, under septic conditions, meldonium increased animal mortality rate compared with the meldonium non-treated group. However, analysis of the tissue oxidative status did not provide support for the detrimental effects of meldonium, nor did the analysis of the tissue inflammatory status showing anti-inflammatory, anti-apoptotic, and anti-necrotic effects of meldonium. After performing tissue lipidomic analysis, we concluded that the potential cause of the meldonium harmful effect is to be found in the overall decreased lipid metabolism. The present study underlines the importance of uninterrupted energy production in sepsis, closely drawing attention to the possible harmful effects of lipid-mobilization impairment caused by certain therapeutics. This could lead to the much-needed revision of the existing guidelines in the clinical treatment of sepsis while paving the way for discovering new therapeutic approaches.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats",
volume = "22",
number = "18",
pages = "9698",
doi = "10.3390/ijms22189698"
}
Đurašević, S., Ružičić, A., Lakić, I., Tosti, T., Đurović, S., Glumac, S., Pavlović, S. Z., Borković-Mitić, S. S., Grigorov, I., Stanković, S., Jasnić, N., Đorđević, J.,& Todorović, Z. B.. (2021). The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats. in International Journal of Molecular Sciences
MDPI., 22(18), 9698.
https://doi.org/10.3390/ijms22189698
Đurašević S, Ružičić A, Lakić I, Tosti T, Đurović S, Glumac S, Pavlović SZ, Borković-Mitić SS, Grigorov I, Stanković S, Jasnić N, Đorđević J, Todorović ZB. The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats. in International Journal of Molecular Sciences. 2021;22(18):9698.
doi:10.3390/ijms22189698 .
Đurašević, Siniša, Ružičić, Aleksandra, Lakić, Iva, Tosti, Tomislav, Đurović, Saša, Glumac, Sofija, Pavlović, Slađan Z., Borković-Mitić, Slavica S., Grigorov, Ilijana, Stanković, Sanja, Jasnić, Nebojša, Đorđević, Jelena, Todorović, Zoran B., "The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats" in International Journal of Molecular Sciences, 22, no. 18 (2021):9698,
https://doi.org/10.3390/ijms22189698 . .
1
2
2
2

Supplementary data for the article:Kostić, A. Ž.; Milinčić, D. D.; Nedić, N.; Gašić, U. M.; Špirović Trifunović, B.; Vojt, D.; Tešić, Ž. L.; Pešić, M. B. Phytochemical Profile and Antioxidant Properties of Bee-Collected Artichoke (Cynara Scolymus) Pollen. Antioxidants 2021, 10 (7), 1091. https://doi.org/10.3390/antiox10071091.

Kostić, Aleksandar Ž.; Milinčić, Danijel D.; Nedić, Nebojša; Gašić, Uroš M.; Špirović Trifunović, Bojana; Vojt, Denis; Tešić, Živoslav Lj.; Pešić, Mirjana B.

(MDPI, 2021)

TY  - DATA
AU  - Kostić, Aleksandar Ž.
AU  - Milinčić, Danijel D.
AU  - Nedić, Nebojša
AU  - Gašić, Uroš M.
AU  - Špirović Trifunović, Bojana
AU  - Vojt, Denis
AU  - Tešić, Živoslav Lj.
AU  - Pešić, Mirjana B.
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4623
PB  - MDPI
T2  - Antioxidants
T1  - Supplementary data for the article:Kostić, A. Ž.; Milinčić, D. D.; Nedić, N.; Gašić, U. M.; Špirović Trifunović, B.; Vojt, D.; Tešić, Ž. L.; Pešić, M. B. Phytochemical Profile and Antioxidant Properties of Bee-Collected Artichoke (Cynara Scolymus) Pollen. Antioxidants 2021, 10 (7), 1091. https://doi.org/10.3390/antiox10071091.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4623
ER  - 
@misc{
author = "Kostić, Aleksandar Ž. and Milinčić, Danijel D. and Nedić, Nebojša and Gašić, Uroš M. and Špirović Trifunović, Bojana and Vojt, Denis and Tešić, Živoslav Lj. and Pešić, Mirjana B.",
year = "2021",
publisher = "MDPI",
journal = "Antioxidants",
title = "Supplementary data for the article:Kostić, A. Ž.; Milinčić, D. D.; Nedić, N.; Gašić, U. M.; Špirović Trifunović, B.; Vojt, D.; Tešić, Ž. L.; Pešić, M. B. Phytochemical Profile and Antioxidant Properties of Bee-Collected Artichoke (Cynara Scolymus) Pollen. Antioxidants 2021, 10 (7), 1091. https://doi.org/10.3390/antiox10071091.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4623"
}
Kostić, A. Ž., Milinčić, D. D., Nedić, N., Gašić, U. M., Špirović Trifunović, B., Vojt, D., Tešić, Ž. Lj.,& Pešić, M. B.. (2021). Supplementary data for the article:Kostić, A. Ž.; Milinčić, D. D.; Nedić, N.; Gašić, U. M.; Špirović Trifunović, B.; Vojt, D.; Tešić, Ž. L.; Pešić, M. B. Phytochemical Profile and Antioxidant Properties of Bee-Collected Artichoke (Cynara Scolymus) Pollen. Antioxidants 2021, 10 (7), 1091. https://doi.org/10.3390/antiox10071091.. in Antioxidants
MDPI..
https://hdl.handle.net/21.15107/rcub_cherry_4623
Kostić AŽ, Milinčić DD, Nedić N, Gašić UM, Špirović Trifunović B, Vojt D, Tešić ŽL, Pešić MB. Supplementary data for the article:Kostić, A. Ž.; Milinčić, D. D.; Nedić, N.; Gašić, U. M.; Špirović Trifunović, B.; Vojt, D.; Tešić, Ž. L.; Pešić, M. B. Phytochemical Profile and Antioxidant Properties of Bee-Collected Artichoke (Cynara Scolymus) Pollen. Antioxidants 2021, 10 (7), 1091. https://doi.org/10.3390/antiox10071091.. in Antioxidants. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4623 .
Kostić, Aleksandar Ž., Milinčić, Danijel D., Nedić, Nebojša, Gašić, Uroš M., Špirović Trifunović, Bojana, Vojt, Denis, Tešić, Živoslav Lj., Pešić, Mirjana B., "Supplementary data for the article:Kostić, A. Ž.; Milinčić, D. D.; Nedić, N.; Gašić, U. M.; Špirović Trifunović, B.; Vojt, D.; Tešić, Ž. L.; Pešić, M. B. Phytochemical Profile and Antioxidant Properties of Bee-Collected Artichoke (Cynara Scolymus) Pollen. Antioxidants 2021, 10 (7), 1091. https://doi.org/10.3390/antiox10071091." in Antioxidants (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4623 .