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Authors

Publications

Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition

Ćurčić, Vladimir; Olszewski, Mateusz; Maciejewska, Natalia; Višnjevac, Aleksandar; Srdić-Rajić, Tatjana; Dobričić, Vladimir; García-Sosa, Alfonso T.; Kokanov, Sanja B.; Araškov, Jovana; Silvestri, Romano; Schüle, Roland; Jung, Manfred; Nikolić, Milan; Filipović, Nenad R.

TY  - JOUR
AU  - Ćurčić, Vladimir
AU  - Olszewski, Mateusz
AU  - Maciejewska, Natalia
AU  - Višnjevac, Aleksandar
AU  - Srdić-Rajić, Tatjana
AU  - Dobričić, Vladimir
AU  - García-Sosa, Alfonso T.
AU  - Kokanov, Sanja B.
AU  - Araškov, Jovana
AU  - Silvestri, Romano
AU  - Schüle, Roland
AU  - Jung, Manfred
AU  - Nikolić, Milan
AU  - Filipović, Nenad R.
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6392
AB  - Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.
PB  - John Wiley and Sons Inc
T2  - Archiv der Pharmazie
T2  - Archiv der Pharmazie
T1  - Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
VL  - n/a
IS  - n/a
SP  - e2300426
DO  - 10.1002/ardp.202300426
ER  - 
@article{
author = "Ćurčić, Vladimir and Olszewski, Mateusz and Maciejewska, Natalia and Višnjevac, Aleksandar and Srdić-Rajić, Tatjana and Dobričić, Vladimir and García-Sosa, Alfonso T. and Kokanov, Sanja B. and Araškov, Jovana and Silvestri, Romano and Schüle, Roland and Jung, Manfred and Nikolić, Milan and Filipović, Nenad R.",
abstract = "Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.",
publisher = "John Wiley and Sons Inc",
journal = "Archiv der Pharmazie, Archiv der Pharmazie",
title = "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition",
volume = "n/a",
number = "n/a",
pages = "e2300426",
doi = "10.1002/ardp.202300426"
}
Ćurčić, V., Olszewski, M., Maciejewska, N., Višnjevac, A., Srdić-Rajić, T., Dobričić, V., García-Sosa, A. T., Kokanov, S. B., Araškov, J., Silvestri, R., Schüle, R., Jung, M., Nikolić, M.,& Filipović, N. R..Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie
John Wiley and Sons Inc., n/a(n/a), e2300426.
https://doi.org/10.1002/ardp.202300426
Ćurčić V, Olszewski M, Maciejewska N, Višnjevac A, Srdić-Rajić T, Dobričić V, García-Sosa AT, Kokanov SB, Araškov J, Silvestri R, Schüle R, Jung M, Nikolić M, Filipović NR. Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie.n/a(n/a):e2300426.
doi:10.1002/ardp.202300426 .
Ćurčić, Vladimir, Olszewski, Mateusz, Maciejewska, Natalia, Višnjevac, Aleksandar, Srdić-Rajić, Tatjana, Dobričić, Vladimir, García-Sosa, Alfonso T., Kokanov, Sanja B., Araškov, Jovana, Silvestri, Romano, Schüle, Roland, Jung, Manfred, Nikolić, Milan, Filipović, Nenad R., "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition" in Archiv der Pharmazie, n/a, no. n/a:e2300426,
https://doi.org/10.1002/ardp.202300426 . .
1

Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring

Jakšić, Jovana; Solymosi, Iris; Hirsch, Andreas; Pérez-Ojeda, M. Eugenia; Mitrović, Aleksandra D.; Maslak, Veselin

(John Wiley and Sons Inc, 2023)

TY  - JOUR
AU  - Jakšić, Jovana
AU  - Solymosi, Iris
AU  - Hirsch, Andreas
AU  - Pérez-Ojeda, M. Eugenia
AU  - Mitrović, Aleksandra D.
AU  - Maslak, Veselin
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6272
AB  - The synthesis and characterization of four dumbbell-shaped fullerene molecules connected by isosorbide and isomannide moieties is presented. Additionally, their electrochemical behavior and their ability to form complexes with [10]cycloparaphenylene ([10]CPP) were investigated. The cyclic voltammetry (CV) results of the fullerene dumbbells demonstrate a high electron affinity, indicating their strong interaction with electron-donating counterparts such as carbon nanorings, which possess complementary charge and shape properties. To study the thermodynamic and kinetic parameters of complexation, isothermal titration calorimetry (ITC) was employed. NMR titration experiments provided further insights into the binding stoichiometries. Two distinct approaches were utilized to create bridged structures: one based on cyclopropane and the other based on furan. Regardless of the type of linker used, all derivatives formed conventional 2 : 1 complexes denoted as [10]CPP2 ⊃C60derivative . However, the methano-dumbbell molecules exhibited distinct binding behavior, resulting in the formation of mono- and bis-pseudorotaxanes, as well as oligomers (polymers). The formation of linear polymers holds significant potential for applications in solar energy conversion processes.
PB  - John Wiley and Sons Inc
T2  - Chemistry (Weinheim an Der Bergstrasse, Germany)
T1  - Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring
VL  - 29
IS  - 44
SP  - e202301061
DO  - 10.1002/chem.202301061
ER  - 
@article{
author = "Jakšić, Jovana and Solymosi, Iris and Hirsch, Andreas and Pérez-Ojeda, M. Eugenia and Mitrović, Aleksandra D. and Maslak, Veselin",
year = "2023",
abstract = "The synthesis and characterization of four dumbbell-shaped fullerene molecules connected by isosorbide and isomannide moieties is presented. Additionally, their electrochemical behavior and their ability to form complexes with [10]cycloparaphenylene ([10]CPP) were investigated. The cyclic voltammetry (CV) results of the fullerene dumbbells demonstrate a high electron affinity, indicating their strong interaction with electron-donating counterparts such as carbon nanorings, which possess complementary charge and shape properties. To study the thermodynamic and kinetic parameters of complexation, isothermal titration calorimetry (ITC) was employed. NMR titration experiments provided further insights into the binding stoichiometries. Two distinct approaches were utilized to create bridged structures: one based on cyclopropane and the other based on furan. Regardless of the type of linker used, all derivatives formed conventional 2 : 1 complexes denoted as [10]CPP2 ⊃C60derivative . However, the methano-dumbbell molecules exhibited distinct binding behavior, resulting in the formation of mono- and bis-pseudorotaxanes, as well as oligomers (polymers). The formation of linear polymers holds significant potential for applications in solar energy conversion processes.",
publisher = "John Wiley and Sons Inc",
journal = "Chemistry (Weinheim an Der Bergstrasse, Germany)",
title = "Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring",
volume = "29",
number = "44",
pages = "e202301061",
doi = "10.1002/chem.202301061"
}
Jakšić, J., Solymosi, I., Hirsch, A., Pérez-Ojeda, M. E., Mitrović, A. D.,& Maslak, V.. (2023). Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring. in Chemistry (Weinheim an Der Bergstrasse, Germany)
John Wiley and Sons Inc., 29(44), e202301061.
https://doi.org/10.1002/chem.202301061
Jakšić J, Solymosi I, Hirsch A, Pérez-Ojeda ME, Mitrović AD, Maslak V. Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring. in Chemistry (Weinheim an Der Bergstrasse, Germany). 2023;29(44):e202301061.
doi:10.1002/chem.202301061 .
Jakšić, Jovana, Solymosi, Iris, Hirsch, Andreas, Pérez-Ojeda, M. Eugenia, Mitrović, Aleksandra D., Maslak, Veselin, "Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring" in Chemistry (Weinheim an Der Bergstrasse, Germany), 29, no. 44 (2023):e202301061,
https://doi.org/10.1002/chem.202301061 . .
17
3
3

Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation

Wedmann, Rudolf; Onderka, Constantin; Wei, Shengwei; Szijarto, Istvan Andras; Miljković, Jan Lj; Mitrović, Aleksandra D.; Lange, Mike; Savitsky, Sergey; Yadav, Pramod Kumar; Torregrossa, Roberta; Harrer, Ellen G.; Harrer, Thomas; Ishii, Isao; Gollasch, Maik; Wood, Mark E.; Galardon, Erwan; Xian, Ming; Whiteman, Matthew; Banerjee, Ruma; Filipović, Miloš R.

(Royal Soc Chemistry, Cambridge, 2016)

TY  - JOUR
AU  - Wedmann, Rudolf
AU  - Onderka, Constantin
AU  - Wei, Shengwei
AU  - Szijarto, Istvan Andras
AU  - Miljković, Jan Lj
AU  - Mitrović, Aleksandra D.
AU  - Lange, Mike
AU  - Savitsky, Sergey
AU  - Yadav, Pramod Kumar
AU  - Torregrossa, Roberta
AU  - Harrer, Ellen G.
AU  - Harrer, Thomas
AU  - Ishii, Isao
AU  - Gollasch, Maik
AU  - Wood, Mark E.
AU  - Galardon, Erwan
AU  - Xian, Ming
AU  - Whiteman, Matthew
AU  - Banerjee, Ruma
AU  - Filipović, Miloš R.
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1925
AB  - Hydrogen sulfide (H2S) has emerged as a signalling molecule capable of regulating several important physiological functions such as blood pressure, neurotransmission and inflammation. The mechanisms behind these effects are still largely elusive and oxidative posttranslational modification of cysteine residues (protein persulfidation or S-sulfhydration) has been proposed as the main pathway for H2S-induced biological and pharmacological effects. As a signalling mechanism, persulfidation has to be controlled. Using an improved tag-switch assay for persulfide detection we show here that protein persulfide levels are controlled by the thioredoxin system. Recombinant thioredoxin showed an almost 10-fold higher reactivity towards cysteine persulfide than towards cystine and readily cleaved protein persulfides as well. This reaction resulted in H2S release suggesting that thioredoxin could be an important regulator of H2S levels from persulfide pools. Inhibition of the thioredoxin system caused an increase in intracellular persulfides, highlighting thioredoxin as a major protein depersulfidase that controls H2S signalling. Finally, using plasma from HIV-1 patients that have higher circulatory levels of thioredoxin, we could prove depersulfidase role in vivo.
PB  - Royal Soc Chemistry, Cambridge
T2  - Chemical Science
T1  - Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation
VL  - 7
IS  - 5
SP  - 3414
EP  - 3426
DO  - 10.1039/c5sc04818d
ER  - 
@article{
author = "Wedmann, Rudolf and Onderka, Constantin and Wei, Shengwei and Szijarto, Istvan Andras and Miljković, Jan Lj and Mitrović, Aleksandra D. and Lange, Mike and Savitsky, Sergey and Yadav, Pramod Kumar and Torregrossa, Roberta and Harrer, Ellen G. and Harrer, Thomas and Ishii, Isao and Gollasch, Maik and Wood, Mark E. and Galardon, Erwan and Xian, Ming and Whiteman, Matthew and Banerjee, Ruma and Filipović, Miloš R.",
year = "2016",
abstract = "Hydrogen sulfide (H2S) has emerged as a signalling molecule capable of regulating several important physiological functions such as blood pressure, neurotransmission and inflammation. The mechanisms behind these effects are still largely elusive and oxidative posttranslational modification of cysteine residues (protein persulfidation or S-sulfhydration) has been proposed as the main pathway for H2S-induced biological and pharmacological effects. As a signalling mechanism, persulfidation has to be controlled. Using an improved tag-switch assay for persulfide detection we show here that protein persulfide levels are controlled by the thioredoxin system. Recombinant thioredoxin showed an almost 10-fold higher reactivity towards cysteine persulfide than towards cystine and readily cleaved protein persulfides as well. This reaction resulted in H2S release suggesting that thioredoxin could be an important regulator of H2S levels from persulfide pools. Inhibition of the thioredoxin system caused an increase in intracellular persulfides, highlighting thioredoxin as a major protein depersulfidase that controls H2S signalling. Finally, using plasma from HIV-1 patients that have higher circulatory levels of thioredoxin, we could prove depersulfidase role in vivo.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Chemical Science",
title = "Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation",
volume = "7",
number = "5",
pages = "3414-3426",
doi = "10.1039/c5sc04818d"
}
Wedmann, R., Onderka, C., Wei, S., Szijarto, I. A., Miljković, J. L., Mitrović, A. D., Lange, M., Savitsky, S., Yadav, P. K., Torregrossa, R., Harrer, E. G., Harrer, T., Ishii, I., Gollasch, M., Wood, M. E., Galardon, E., Xian, M., Whiteman, M., Banerjee, R.,& Filipović, M. R.. (2016). Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation. in Chemical Science
Royal Soc Chemistry, Cambridge., 7(5), 3414-3426.
https://doi.org/10.1039/c5sc04818d
Wedmann R, Onderka C, Wei S, Szijarto IA, Miljković JL, Mitrović AD, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipović MR. Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation. in Chemical Science. 2016;7(5):3414-3426.
doi:10.1039/c5sc04818d .
Wedmann, Rudolf, Onderka, Constantin, Wei, Shengwei, Szijarto, Istvan Andras, Miljković, Jan Lj, Mitrović, Aleksandra D., Lange, Mike, Savitsky, Sergey, Yadav, Pramod Kumar, Torregrossa, Roberta, Harrer, Ellen G., Harrer, Thomas, Ishii, Isao, Gollasch, Maik, Wood, Mark E., Galardon, Erwan, Xian, Ming, Whiteman, Matthew, Banerjee, Ruma, Filipović, Miloš R., "Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation" in Chemical Science, 7, no. 5 (2016):3414-3426,
https://doi.org/10.1039/c5sc04818d . .
172
107
155

Supplementary material for the article: Wedmann, R.; Onderka, C.; Wei, S.; Szijártó, I. A.; Miljkovic, J. L.; Mitrovic, A.; Lange, M.; Savitsky, S.; Yadav, P. K.; Torregrossa, R.; et al. Improved Tag-Switch Method Reveals That Thioredoxin Acts as Depersulfidase and Controls the Intracellular Levels of Protein Persulfidation. Chemical Science 2016, 7 (5), 3414–3426. https://doi.org/10.1039/c5sc04818d

Wedmann, Rudolf; Onderka, Constantin; Wei, Shengwei; Szijarto, Istvan Andras; Miljković, Jan Lj; Mitrović, Aleksandra D.; Lange, Mike; Savitsky, Sergey; Yadav, Pramod Kumar; Torregrossa, Roberta; Harrer, Ellen G.; Harrer, Thomas; Ishii, Isao; Gollasch, Maik; Wood, Mark E.; Galardon, Erwan; Xian, Ming; Whiteman, Matthew; Banerjee, Ruma; Filipović, Miloš R.

(Royal Soc Chemistry, Cambridge, 2016)

TY  - DATA
AU  - Wedmann, Rudolf
AU  - Onderka, Constantin
AU  - Wei, Shengwei
AU  - Szijarto, Istvan Andras
AU  - Miljković, Jan Lj
AU  - Mitrović, Aleksandra D.
AU  - Lange, Mike
AU  - Savitsky, Sergey
AU  - Yadav, Pramod Kumar
AU  - Torregrossa, Roberta
AU  - Harrer, Ellen G.
AU  - Harrer, Thomas
AU  - Ishii, Isao
AU  - Gollasch, Maik
AU  - Wood, Mark E.
AU  - Galardon, Erwan
AU  - Xian, Ming
AU  - Whiteman, Matthew
AU  - Banerjee, Ruma
AU  - Filipović, Miloš R.
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3543
PB  - Royal Soc Chemistry, Cambridge
T2  - Chemical Science
T1  - Supplementary material for the article: Wedmann, R.; Onderka, C.; Wei, S.; Szijártó, I. A.; Miljkovic, J. L.; Mitrovic, A.; Lange, M.; Savitsky, S.; Yadav, P. K.; Torregrossa, R.; et al. Improved Tag-Switch Method Reveals That Thioredoxin Acts as Depersulfidase and Controls the Intracellular Levels of Protein Persulfidation. Chemical Science 2016, 7 (5), 3414–3426. https://doi.org/10.1039/c5sc04818d
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3543
ER  - 
@misc{
author = "Wedmann, Rudolf and Onderka, Constantin and Wei, Shengwei and Szijarto, Istvan Andras and Miljković, Jan Lj and Mitrović, Aleksandra D. and Lange, Mike and Savitsky, Sergey and Yadav, Pramod Kumar and Torregrossa, Roberta and Harrer, Ellen G. and Harrer, Thomas and Ishii, Isao and Gollasch, Maik and Wood, Mark E. and Galardon, Erwan and Xian, Ming and Whiteman, Matthew and Banerjee, Ruma and Filipović, Miloš R.",
year = "2016",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Chemical Science",
title = "Supplementary material for the article: Wedmann, R.; Onderka, C.; Wei, S.; Szijártó, I. A.; Miljkovic, J. L.; Mitrovic, A.; Lange, M.; Savitsky, S.; Yadav, P. K.; Torregrossa, R.; et al. Improved Tag-Switch Method Reveals That Thioredoxin Acts as Depersulfidase and Controls the Intracellular Levels of Protein Persulfidation. Chemical Science 2016, 7 (5), 3414–3426. https://doi.org/10.1039/c5sc04818d",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3543"
}
Wedmann, R., Onderka, C., Wei, S., Szijarto, I. A., Miljković, J. L., Mitrović, A. D., Lange, M., Savitsky, S., Yadav, P. K., Torregrossa, R., Harrer, E. G., Harrer, T., Ishii, I., Gollasch, M., Wood, M. E., Galardon, E., Xian, M., Whiteman, M., Banerjee, R.,& Filipović, M. R.. (2016). Supplementary material for the article: Wedmann, R.; Onderka, C.; Wei, S.; Szijártó, I. A.; Miljkovic, J. L.; Mitrovic, A.; Lange, M.; Savitsky, S.; Yadav, P. K.; Torregrossa, R.; et al. Improved Tag-Switch Method Reveals That Thioredoxin Acts as Depersulfidase and Controls the Intracellular Levels of Protein Persulfidation. Chemical Science 2016, 7 (5), 3414–3426. https://doi.org/10.1039/c5sc04818d. in Chemical Science
Royal Soc Chemistry, Cambridge..
https://hdl.handle.net/21.15107/rcub_cherry_3543
Wedmann R, Onderka C, Wei S, Szijarto IA, Miljković JL, Mitrović AD, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipović MR. Supplementary material for the article: Wedmann, R.; Onderka, C.; Wei, S.; Szijártó, I. A.; Miljkovic, J. L.; Mitrovic, A.; Lange, M.; Savitsky, S.; Yadav, P. K.; Torregrossa, R.; et al. Improved Tag-Switch Method Reveals That Thioredoxin Acts as Depersulfidase and Controls the Intracellular Levels of Protein Persulfidation. Chemical Science 2016, 7 (5), 3414–3426. https://doi.org/10.1039/c5sc04818d. in Chemical Science. 2016;.
https://hdl.handle.net/21.15107/rcub_cherry_3543 .
Wedmann, Rudolf, Onderka, Constantin, Wei, Shengwei, Szijarto, Istvan Andras, Miljković, Jan Lj, Mitrović, Aleksandra D., Lange, Mike, Savitsky, Sergey, Yadav, Pramod Kumar, Torregrossa, Roberta, Harrer, Ellen G., Harrer, Thomas, Ishii, Isao, Gollasch, Maik, Wood, Mark E., Galardon, Erwan, Xian, Ming, Whiteman, Matthew, Banerjee, Ruma, Filipović, Miloš R., "Supplementary material for the article: Wedmann, R.; Onderka, C.; Wei, S.; Szijártó, I. A.; Miljkovic, J. L.; Mitrovic, A.; Lange, M.; Savitsky, S.; Yadav, P. K.; Torregrossa, R.; et al. Improved Tag-Switch Method Reveals That Thioredoxin Acts as Depersulfidase and Controls the Intracellular Levels of Protein Persulfidation. Chemical Science 2016, 7 (5), 3414–3426. https://doi.org/10.1039/c5sc04818d" in Chemical Science (2016),
https://hdl.handle.net/21.15107/rcub_cherry_3543 .

Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet

Chen, Qiushui; Utech, Stefanie; Chen, Dong; Prodanović, Radivoje; Lin, Jin-Ming; Weitz, David A.

(Royal Soc Chemistry, Cambridge, 2016)

TY  - JOUR
AU  - Chen, Qiushui
AU  - Utech, Stefanie
AU  - Chen, Dong
AU  - Prodanović, Radivoje
AU  - Lin, Jin-Ming
AU  - Weitz, David A.
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2820
AB  - This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.
PB  - Royal Soc Chemistry, Cambridge
T2  - Lab on A Chip
T1  - Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet
VL  - 16
IS  - 8
SP  - 1346
EP  - 1349
DO  - 10.1039/c6lc00231e
ER  - 
@article{
author = "Chen, Qiushui and Utech, Stefanie and Chen, Dong and Prodanović, Radivoje and Lin, Jin-Ming and Weitz, David A.",
year = "2016",
abstract = "This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Lab on A Chip",
title = "Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet",
volume = "16",
number = "8",
pages = "1346-1349",
doi = "10.1039/c6lc00231e"
}
Chen, Q., Utech, S., Chen, D., Prodanović, R., Lin, J.,& Weitz, D. A.. (2016). Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet. in Lab on A Chip
Royal Soc Chemistry, Cambridge., 16(8), 1346-1349.
https://doi.org/10.1039/c6lc00231e
Chen Q, Utech S, Chen D, Prodanović R, Lin J, Weitz DA. Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet. in Lab on A Chip. 2016;16(8):1346-1349.
doi:10.1039/c6lc00231e .
Chen, Qiushui, Utech, Stefanie, Chen, Dong, Prodanović, Radivoje, Lin, Jin-Ming, Weitz, David A., "Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet" in Lab on A Chip, 16, no. 8 (2016):1346-1349,
https://doi.org/10.1039/c6lc00231e . .
11
169
121
152

Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet

Chen, Qiushui; Utech, Stefanie; Chen, Dong; Prodanović, Radivoje; Lin, Jin-Ming; Weitz, David A.

(Royal Soc Chemistry, Cambridge, 2016)

TY  - JOUR
AU  - Chen, Qiushui
AU  - Utech, Stefanie
AU  - Chen, Dong
AU  - Prodanović, Radivoje
AU  - Lin, Jin-Ming
AU  - Weitz, David A.
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1917
AB  - This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.
PB  - Royal Soc Chemistry, Cambridge
T2  - Lab on A Chip
T1  - Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet
VL  - 16
IS  - 8
SP  - 1346
EP  - 1349
DO  - 10.1039/c6lc00231e
ER  - 
@article{
author = "Chen, Qiushui and Utech, Stefanie and Chen, Dong and Prodanović, Radivoje and Lin, Jin-Ming and Weitz, David A.",
year = "2016",
abstract = "This paper reports a droplet-based microfluidic approach to fabricate a large number of monodisperse, portable microtissues, each in an individual drop. We use water-water-oil double emulsions as templates and spatially assemble hepatocytes in the core and fibroblasts in the shell, forming a 3D liver model in a drop.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Lab on A Chip",
title = "Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet",
volume = "16",
number = "8",
pages = "1346-1349",
doi = "10.1039/c6lc00231e"
}
Chen, Q., Utech, S., Chen, D., Prodanović, R., Lin, J.,& Weitz, D. A.. (2016). Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet. in Lab on A Chip
Royal Soc Chemistry, Cambridge., 16(8), 1346-1349.
https://doi.org/10.1039/c6lc00231e
Chen Q, Utech S, Chen D, Prodanović R, Lin J, Weitz DA. Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet. in Lab on A Chip. 2016;16(8):1346-1349.
doi:10.1039/c6lc00231e .
Chen, Qiushui, Utech, Stefanie, Chen, Dong, Prodanović, Radivoje, Lin, Jin-Ming, Weitz, David A., "Controlled assembly of heterotypic cells in a core-shell scaffold: organ in a droplet" in Lab on A Chip, 16, no. 8 (2016):1346-1349,
https://doi.org/10.1039/c6lc00231e . .
11
169
121
152

Supplementary data for the article: Chen, Q.; Utech, S.; Chen, D.; Prodanovic, R.; Lin, J.-M.; Weitz, D. A. Controlled Assembly of Heterotypic Cells in a Core-Shell Scaffold: Organ in a Droplet. Lab on a Chip 2016, 16 (8), 1346–1349. https://doi.org/10.1039/c6lc00231e

Chen, Qiushui; Utech, Stefanie; Chen, Dong; Prodanović, Radivoje; Lin, Jin-Ming; Weitz, David A.

(Royal Soc Chemistry, Cambridge, 2016)

TY  - DATA
AU  - Chen, Qiushui
AU  - Utech, Stefanie
AU  - Chen, Dong
AU  - Prodanović, Radivoje
AU  - Lin, Jin-Ming
AU  - Weitz, David A.
PY  - 2016
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3427
PB  - Royal Soc Chemistry, Cambridge
T2  - Lab on A Chip
T1  - Supplementary data for the article: Chen, Q.; Utech, S.; Chen, D.; Prodanovic, R.; Lin, J.-M.; Weitz, D. A. Controlled Assembly of Heterotypic Cells in a Core-Shell Scaffold: Organ in a Droplet. Lab on a Chip 2016, 16 (8), 1346–1349. https://doi.org/10.1039/c6lc00231e
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3427
ER  - 
@misc{
author = "Chen, Qiushui and Utech, Stefanie and Chen, Dong and Prodanović, Radivoje and Lin, Jin-Ming and Weitz, David A.",
year = "2016",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Lab on A Chip",
title = "Supplementary data for the article: Chen, Q.; Utech, S.; Chen, D.; Prodanovic, R.; Lin, J.-M.; Weitz, D. A. Controlled Assembly of Heterotypic Cells in a Core-Shell Scaffold: Organ in a Droplet. Lab on a Chip 2016, 16 (8), 1346–1349. https://doi.org/10.1039/c6lc00231e",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3427"
}
Chen, Q., Utech, S., Chen, D., Prodanović, R., Lin, J.,& Weitz, D. A.. (2016). Supplementary data for the article: Chen, Q.; Utech, S.; Chen, D.; Prodanovic, R.; Lin, J.-M.; Weitz, D. A. Controlled Assembly of Heterotypic Cells in a Core-Shell Scaffold: Organ in a Droplet. Lab on a Chip 2016, 16 (8), 1346–1349. https://doi.org/10.1039/c6lc00231e. in Lab on A Chip
Royal Soc Chemistry, Cambridge..
https://hdl.handle.net/21.15107/rcub_cherry_3427
Chen Q, Utech S, Chen D, Prodanović R, Lin J, Weitz DA. Supplementary data for the article: Chen, Q.; Utech, S.; Chen, D.; Prodanovic, R.; Lin, J.-M.; Weitz, D. A. Controlled Assembly of Heterotypic Cells in a Core-Shell Scaffold: Organ in a Droplet. Lab on a Chip 2016, 16 (8), 1346–1349. https://doi.org/10.1039/c6lc00231e. in Lab on A Chip. 2016;.
https://hdl.handle.net/21.15107/rcub_cherry_3427 .
Chen, Qiushui, Utech, Stefanie, Chen, Dong, Prodanović, Radivoje, Lin, Jin-Ming, Weitz, David A., "Supplementary data for the article: Chen, Q.; Utech, S.; Chen, D.; Prodanovic, R.; Lin, J.-M.; Weitz, D. A. Controlled Assembly of Heterotypic Cells in a Core-Shell Scaffold: Organ in a Droplet. Lab on a Chip 2016, 16 (8), 1346–1349. https://doi.org/10.1039/c6lc00231e" in Lab on A Chip (2016),
https://hdl.handle.net/21.15107/rcub_cherry_3427 .