TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir B.
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana B.
AU  - Kostić-Rajačić, Slađana V.
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 

@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir B. and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana B. and Kostić-Rajačić, Slađana V.",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}

Penjišević, J., Šukalović, V. B., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845

Penjišević J, Šukalović VB, Dukić-Stefanović S, Deuther-Conrad W, Andrić DB, Kostić-Rajačić SV. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

Penjišević, Jelena , Šukalović, Vladimir B., Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana B., Kostić-Rajačić, Slađana V., "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

TY  - DATA
AU  - Đurđić, Slađana
AU  - Vlahović, Filip
AU  - Markićević, Milan
AU  - Mutić, Jelena
AU  - Manojlović, Dragan
AU  - Stanković, Vesna
AU  - Švorc, Ľubomír
AU  - Stanković, Dalibor
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5812
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5839
AB  - Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.
PB  - MDPI
T2  - Chemosensors
T1  - Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015
VL  - 11
IS  - 1
SP  - 15
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5839
ER  - 

@misc{
author = "Đurđić, Slađana and Vlahović, Filip and Markićević, Milan and Mutić, Jelena and Manojlović, Dragan and Stanković, Vesna and Švorc, Ľubomír and Stanković, Dalibor",
abstract = "Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.",
publisher = "MDPI",
journal = "Chemosensors",
title = "Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015",
volume = "11",
number = "1",
pages = "15",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5839"
}

Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D..Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015. in Chemosensors
MDPI., 11(1), 15.
https://hdl.handle.net/21.15107/rcub_cherry_5839

Đurđić S, Vlahović F, Markićević M, Mutić J, Manojlović D, Stanković V, Švorc Ľ, Stanković D. Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015. in Chemosensors.11(1):15.
https://hdl.handle.net/21.15107/rcub_cherry_5839 .

Đurđić, Slađana, Vlahović, Filip, Markićević, Milan, Mutić, Jelena, Manojlović, Dragan, Stanković, Vesna, Švorc, Ľubomír, Stanković, Dalibor, "Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015" in Chemosensors, 11, no. 1:15,
https://hdl.handle.net/21.15107/rcub_cherry_5839 .

TY  - JOUR
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir B.
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana B.
AU  - Kostić-Rajačić, Slađana V.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5819
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency
VL  - 16
IS  - 4
SP  - 104636
DO  - 10.1016/j.arabjc.2023.104636
ER  - 

@article{
author = "Penjišević, Jelena  and Šukalović, Vladimir B. and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana B. and Kostić-Rajačić, Slađana V.",
year = "2023",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency",
volume = "16",
number = "4",
pages = "104636",
doi = "10.1016/j.arabjc.2023.104636"
}

Penjišević, J., Šukalović, V. B., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://doi.org/10.1016/j.arabjc.2023.104636

Penjišević J, Šukalović VB, Dukić-Stefanović S, Deuther-Conrad W, Andrić DB, Kostić-Rajačić SV. Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry. 2023;16(4):104636.
doi:10.1016/j.arabjc.2023.104636 .

Penjišević, Jelena , Šukalović, Vladimir B., Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana B., Kostić-Rajačić, Slađana V., "Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency" in Arabian Journal of Chemistry, 16, no. 4 (2023):104636,
https://doi.org/10.1016/j.arabjc.2023.104636 . .

TY  - JOUR
AU  - Šokarda Slavić, Marinela
AU  - Margetić, Aleksandra
AU  - Dojnov, Biljana
AU  - Vujčić, Miroslava
AU  - Mišić, Milan
AU  - Božić, Nataša
AU  - Vujčić, Zoran
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5796
AB  - Bioethanol is one of the main bio-based molecules produced mainly from sugar cane, molasses and corn. Its environmental advantages allow it to be considered as safe and the cleanest fuel alternative. Starch is a widespread renewable carbohydrate conventionally used for bioethanol production via energy demanding liquefaction and saccharification processes. Raw starch hydrolysis using enzymes capable of degrading it below the gelatinization temperature significantly simplifies the process and reduces the cost of starch processing. In this study, an innovative modified simultaneous saccharification and fermentation process is proposed for the production of bioethanol from highly concentrated raw corn starch (30 % w/v). A two-step synergistic hydrolysis and fermentation was carried out in a single bioreactor vessel. To ensure high process efficiency, factors influencing the hydrolysis of concentrated raw corn starch by raw starch degrading α-amylase from Bacillus paralicheniformis ATCC 9945a (BliAmy) and commercial glucoamylase were investigated. Box–Behnken experimental design was used to predict the effects of different ratios of added enzymes, glucoamylase addition time, incubation time, and pH on hydrolysis yield. Optimal conditions for the highest yield of hydrolysis of raw corn starch (90 %) were obtained after 8 h using 5.0 IU BliAmy per mg of starch and 0.5 % (v/v) glucoamylase at pH 4.5 and 60 °C. Obtained glucose was further fermented with Saccharomyces cerevisiae at 30 °C in the same vessel for bioethanol production. Bioethanol concentration at 129.2 g/L, with productivity of 2.94 g/L/h and ethanol yield (YP/S) at 0.50 g EtOH/g total sugar, equivalent to 87.8 % theoretical yield, was obtained by modified simultaneous saccharification and fermentation. This work enriches the information of bioethanol production and offers a novel strategy for raw starch hydrolysis under industrial conditions.
T2  - Fuel
T1  - Modified simultaneous saccharification and fermentation for the production of bioethanol from highly concentrated raw corn starch
VL  - 338
SP  - 127363
DO  - 10.1016/j.fuel.2022.127363
ER  - 

@article{
author = "Šokarda Slavić, Marinela and Margetić, Aleksandra and Dojnov, Biljana and Vujčić, Miroslava and Mišić, Milan and Božić, Nataša and Vujčić, Zoran",
year = "2023",
abstract = "Bioethanol is one of the main bio-based molecules produced mainly from sugar cane, molasses and corn. Its environmental advantages allow it to be considered as safe and the cleanest fuel alternative. Starch is a widespread renewable carbohydrate conventionally used for bioethanol production via energy demanding liquefaction and saccharification processes. Raw starch hydrolysis using enzymes capable of degrading it below the gelatinization temperature significantly simplifies the process and reduces the cost of starch processing. In this study, an innovative modified simultaneous saccharification and fermentation process is proposed for the production of bioethanol from highly concentrated raw corn starch (30 % w/v). A two-step synergistic hydrolysis and fermentation was carried out in a single bioreactor vessel. To ensure high process efficiency, factors influencing the hydrolysis of concentrated raw corn starch by raw starch degrading α-amylase from Bacillus paralicheniformis ATCC 9945a (BliAmy) and commercial glucoamylase were investigated. Box–Behnken experimental design was used to predict the effects of different ratios of added enzymes, glucoamylase addition time, incubation time, and pH on hydrolysis yield. Optimal conditions for the highest yield of hydrolysis of raw corn starch (90 %) were obtained after 8 h using 5.0 IU BliAmy per mg of starch and 0.5 % (v/v) glucoamylase at pH 4.5 and 60 °C. Obtained glucose was further fermented with Saccharomyces cerevisiae at 30 °C in the same vessel for bioethanol production. Bioethanol concentration at 129.2 g/L, with productivity of 2.94 g/L/h and ethanol yield (YP/S) at 0.50 g EtOH/g total sugar, equivalent to 87.8 % theoretical yield, was obtained by modified simultaneous saccharification and fermentation. This work enriches the information of bioethanol production and offers a novel strategy for raw starch hydrolysis under industrial conditions.",
journal = "Fuel",
title = "Modified simultaneous saccharification and fermentation for the production of bioethanol from highly concentrated raw corn starch",
volume = "338",
pages = "127363",
doi = "10.1016/j.fuel.2022.127363"
}

Šokarda Slavić, M., Margetić, A., Dojnov, B., Vujčić, M., Mišić, M., Božić, N.,& Vujčić, Z.. (2023). Modified simultaneous saccharification and fermentation for the production of bioethanol from highly concentrated raw corn starch. in Fuel, 338, 127363.
https://doi.org/10.1016/j.fuel.2022.127363

Šokarda Slavić M, Margetić A, Dojnov B, Vujčić M, Mišić M, Božić N, Vujčić Z. Modified simultaneous saccharification and fermentation for the production of bioethanol from highly concentrated raw corn starch. in Fuel. 2023;338:127363.
doi:10.1016/j.fuel.2022.127363 .

Šokarda Slavić, Marinela, Margetić, Aleksandra, Dojnov, Biljana, Vujčić, Miroslava, Mišić, Milan, Božić, Nataša, Vujčić, Zoran, "Modified simultaneous saccharification and fermentation for the production of bioethanol from highly concentrated raw corn starch" in Fuel, 338 (2023):127363,
https://doi.org/10.1016/j.fuel.2022.127363 . .

TY  - DATA
AU  - Šokarda Slavić, Marinela
AU  - Margetić, Aleksandra
AU  - Dojnov, Biljana
AU  - Vujčić, Miroslava
AU  - Mišić, Milan
AU  - Božić, Nataša
AU  - Vujčić, Zoran
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5836
AB  - Bioethanol is one of the main bio-based molecules produced mainly from sugar cane, molasses and corn. Its environmental advantages allow it to be considered as safe and the cleanest fuel alternative. Starch is a widespread renewable carbohydrate conventionally used for bioethanol production via energy demanding liquefaction and saccharification processes. Raw starch hydrolysis using enzymes capable of degrading it below the gelatinization temperature significantly simplifies the process and reduces the cost of starch processing. In this study, an innovative modified simultaneous saccharification and fermentation process is proposed for the production of bioethanol from highly concentrated raw corn starch (30 % w/v). A two-step synergistic hydrolysis and fermentation was carried out in a single bioreactor vessel. To ensure high process efficiency, factors influencing the hydrolysis of concentrated raw corn starch by raw starch degrading α-amylase from Bacillus paralicheniformis ATCC 9945a (BliAmy) and commercial glucoamylase were investigated. Box–Behnken experimental design was used to predict the effects of different ratios of added enzymes, glucoamylase addition time, incubation time, and pH on hydrolysis yield. Optimal conditions for the highest yield of hydrolysis of raw corn starch (90 %) were obtained after 8 h using 5.0 IU BliAmy per mg of starch and 0.5 % (v/v) glucoamylase at pH 4.5 and 60 °C. Obtained glucose was further fermented with Saccharomyces cerevisiae at 30 °C in the same vessel for bioethanol production. Bioethanol concentration at 129.2 g/L, with productivity of 2.94 g/L/h and ethanol yield (YP/S) at 0.50 g EtOH/g total sugar, equivalent to 87.8 % theoretical yield, was obtained by modified simultaneous saccharification and fermentation. This work enriches the information of bioethanol production and offers a novel strategy for raw starch hydrolysis under industrial conditions.
T2  - Fuel
T1  - Supplementary material for: Šokarda Slavić, M., Margetić, A., Dojnov, B., Vujčić, M., Mišić, M., Božić, N.,& Vujčić, Z.. (2023). Modified simultaneous saccharification and fermentation for the production of bioethanol from highly concentrated raw corn starch. in Fuel, 338, 127363. https://doi.org/10.1016/j.fuel.2022.127363
VL  - 338
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5836
ER  - 

@misc{
author = "Šokarda Slavić, Marinela and Margetić, Aleksandra and Dojnov, Biljana and Vujčić, Miroslava and Mišić, Milan and Božić, Nataša and Vujčić, Zoran",
year = "2023",
abstract = "Bioethanol is one of the main bio-based molecules produced mainly from sugar cane, molasses and corn. Its environmental advantages allow it to be considered as safe and the cleanest fuel alternative. Starch is a widespread renewable carbohydrate conventionally used for bioethanol production via energy demanding liquefaction and saccharification processes. Raw starch hydrolysis using enzymes capable of degrading it below the gelatinization temperature significantly simplifies the process and reduces the cost of starch processing. In this study, an innovative modified simultaneous saccharification and fermentation process is proposed for the production of bioethanol from highly concentrated raw corn starch (30 % w/v). A two-step synergistic hydrolysis and fermentation was carried out in a single bioreactor vessel. To ensure high process efficiency, factors influencing the hydrolysis of concentrated raw corn starch by raw starch degrading α-amylase from Bacillus paralicheniformis ATCC 9945a (BliAmy) and commercial glucoamylase were investigated. Box–Behnken experimental design was used to predict the effects of different ratios of added enzymes, glucoamylase addition time, incubation time, and pH on hydrolysis yield. Optimal conditions for the highest yield of hydrolysis of raw corn starch (90 %) were obtained after 8 h using 5.0 IU BliAmy per mg of starch and 0.5 % (v/v) glucoamylase at pH 4.5 and 60 °C. Obtained glucose was further fermented with Saccharomyces cerevisiae at 30 °C in the same vessel for bioethanol production. Bioethanol concentration at 129.2 g/L, with productivity of 2.94 g/L/h and ethanol yield (YP/S) at 0.50 g EtOH/g total sugar, equivalent to 87.8 % theoretical yield, was obtained by modified simultaneous saccharification and fermentation. This work enriches the information of bioethanol production and offers a novel strategy for raw starch hydrolysis under industrial conditions.",
journal = "Fuel",
title = "Supplementary material for: Šokarda Slavić, M., Margetić, A., Dojnov, B., Vujčić, M., Mišić, M., Božić, N.,& Vujčić, Z.. (2023). Modified simultaneous saccharification and fermentation for the production of bioethanol from highly concentrated raw corn starch. in Fuel, 338, 127363. https://doi.org/10.1016/j.fuel.2022.127363",
volume = "338",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5836"
}

Šokarda Slavić, M., Margetić, A., Dojnov, B., Vujčić, M., Mišić, M., Božić, N.,& Vujčić, Z.. (2023). Supplementary material for: Šokarda Slavić, M., Margetić, A., Dojnov, B., Vujčić, M., Mišić, M., Božić, N.,& Vujčić, Z.. (2023). Modified simultaneous saccharification and fermentation for the production of bioethanol from highly concentrated raw corn starch. in Fuel, 338, 127363. https://doi.org/10.1016/j.fuel.2022.127363. in Fuel, 338.
https://hdl.handle.net/21.15107/rcub_cherry_5836

Šokarda Slavić M, Margetić A, Dojnov B, Vujčić M, Mišić M, Božić N, Vujčić Z. Supplementary material for: Šokarda Slavić, M., Margetić, A., Dojnov, B., Vujčić, M., Mišić, M., Božić, N.,& Vujčić, Z.. (2023). Modified simultaneous saccharification and fermentation for the production of bioethanol from highly concentrated raw corn starch. in Fuel, 338, 127363. https://doi.org/10.1016/j.fuel.2022.127363. in Fuel. 2023;338.
https://hdl.handle.net/21.15107/rcub_cherry_5836 .

Šokarda Slavić, Marinela, Margetić, Aleksandra, Dojnov, Biljana, Vujčić, Miroslava, Mišić, Milan, Božić, Nataša, Vujčić, Zoran, "Supplementary material for: Šokarda Slavić, M., Margetić, A., Dojnov, B., Vujčić, M., Mišić, M., Božić, N.,& Vujčić, Z.. (2023). Modified simultaneous saccharification and fermentation for the production of bioethanol from highly concentrated raw corn starch. in Fuel, 338, 127363. https://doi.org/10.1016/j.fuel.2022.127363" in Fuel, 338 (2023),
https://hdl.handle.net/21.15107/rcub_cherry_5836 .

TY  - DATA
AU  - Pešić, Miloš P.
AU  - Krstić, Jugoslav
AU  - Verbić, Tatjana
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5841
AB  - Molecularly imprinting technology was applied for preparing selec­tive sorbents for benzophenone-4 (BP4), an organic UV filter used in sun­screens and cosmetics. Several imprinted polymers were prepared by bulk polymerization, using BP4 as template. Combination of stability (mechanical and chemical), selectivity and robustness of the imprinted polymers with BP4 properties resulted in a successful imprinting process (imprinting factors in range 1.05–2.60). The prepared polymers were characterised by infrared spec­tro­scopy, elemental analysis, conductometric titrations and nitrogen physi­sorp­tion at 77 K. Adsorption capacities and selectivity towards 7 other organic UV filters (benzophenone-3, benzophenone-8, homosalate, butyl methoxydi­ben­zo­ylmethane, ethyl hexyl salicylate, ethyl hexyl p-dimethylamino benzoate and ethyl hexyl p-methoxycinnamate) were determined, proving high adsorption capacity and high selectivity for BP4 binding. The highest adsorption capacity was observed for 4-vinylpyridine/ethylene glycol dimethacrylate co-polymer prepared in dimethyl sulfoxide (1.108 mmol g-1). The imprinted polymer with the highest binding capacity was applied to solid phase extraction of BP4 from aqueous solutions with 98.5 % efficiency.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Supplementary material for: Pešić, M. P., Krstić, J.,& Verbić, T.. (2023). Highly selective water-compatible molecularly imprinted polymers for benzophenone-4: Scientific paper. in Journal of the Serbian Chemical Society Belgrade : Serbian Chemical Society., 88(1), 55-68. https://doi.org/10.2298/JSC22032540P
VL  - 88
IS  - 1
SP  - 55
EP  - 68
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5841
ER  - 

@misc{
author = "Pešić, Miloš P. and Krstić, Jugoslav and Verbić, Tatjana",
year = "2023",
abstract = "Molecularly imprinting technology was applied for preparing selec­tive sorbents for benzophenone-4 (BP4), an organic UV filter used in sun­screens and cosmetics. Several imprinted polymers were prepared by bulk polymerization, using BP4 as template. Combination of stability (mechanical and chemical), selectivity and robustness of the imprinted polymers with BP4 properties resulted in a successful imprinting process (imprinting factors in range 1.05–2.60). The prepared polymers were characterised by infrared spec­tro­scopy, elemental analysis, conductometric titrations and nitrogen physi­sorp­tion at 77 K. Adsorption capacities and selectivity towards 7 other organic UV filters (benzophenone-3, benzophenone-8, homosalate, butyl methoxydi­ben­zo­ylmethane, ethyl hexyl salicylate, ethyl hexyl p-dimethylamino benzoate and ethyl hexyl p-methoxycinnamate) were determined, proving high adsorption capacity and high selectivity for BP4 binding. The highest adsorption capacity was observed for 4-vinylpyridine/ethylene glycol dimethacrylate co-polymer prepared in dimethyl sulfoxide (1.108 mmol g-1). The imprinted polymer with the highest binding capacity was applied to solid phase extraction of BP4 from aqueous solutions with 98.5 % efficiency.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Supplementary material for: Pešić, M. P., Krstić, J.,& Verbić, T.. (2023). Highly selective water-compatible molecularly imprinted polymers for benzophenone-4: Scientific paper. in Journal of the Serbian Chemical Society Belgrade : Serbian Chemical Society., 88(1), 55-68. https://doi.org/10.2298/JSC22032540P",
volume = "88",
number = "1",
pages = "55-68",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5841"
}

Pešić, M. P., Krstić, J.,& Verbić, T.. (2023). Supplementary material for: Pešić, M. P., Krstić, J.,& Verbić, T.. (2023). Highly selective water-compatible molecularly imprinted polymers for benzophenone-4: Scientific paper. in Journal of the Serbian Chemical Society Belgrade : Serbian Chemical Society., 88(1), 55-68. https://doi.org/10.2298/JSC22032540P. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 88(1), 55-68.
https://hdl.handle.net/21.15107/rcub_cherry_5841

Pešić MP, Krstić J, Verbić T. Supplementary material for: Pešić, M. P., Krstić, J.,& Verbić, T.. (2023). Highly selective water-compatible molecularly imprinted polymers for benzophenone-4: Scientific paper. in Journal of the Serbian Chemical Society Belgrade : Serbian Chemical Society., 88(1), 55-68. https://doi.org/10.2298/JSC22032540P. in Journal of the Serbian Chemical Society. 2023;88(1):55-68.
https://hdl.handle.net/21.15107/rcub_cherry_5841 .

Pešić, Miloš P., Krstić, Jugoslav, Verbić, Tatjana, "Supplementary material for: Pešić, M. P., Krstić, J.,& Verbić, T.. (2023). Highly selective water-compatible molecularly imprinted polymers for benzophenone-4: Scientific paper. in Journal of the Serbian Chemical Society Belgrade : Serbian Chemical Society., 88(1), 55-68. https://doi.org/10.2298/JSC22032540P" in Journal of the Serbian Chemical Society, 88, no. 1 (2023):55-68,
https://hdl.handle.net/21.15107/rcub_cherry_5841 .

TY  - JOUR
AU  - Pešić, Miloš P.
AU  - Krstić, Jugoslav
AU  - Verbić, Tatjana
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5817
AB  - Molecularly imprinting technology was applied for preparing selec­tive sorbents for benzophenone-4 (BP4), an organic UV filter used in sun­screens and cosmetics. Several imprinted polymers were prepared by bulk polymerization, using BP4 as template. Combination of stability (mechanical and chemical), selectivity and robustness of the imprinted polymers with BP4 properties resulted in a successful imprinting process (imprinting factors in range 1.05–2.60). The prepared polymers were characterised by infrared spec­tro­scopy, elemental analysis, conductometric titrations and nitrogen physi­sorp­tion at 77 K. Adsorption capacities and selectivity towards 7 other organic UV filters (benzophenone-3, benzophenone-8, homosalate, butyl methoxydi­ben­zo­ylmethane, ethyl hexyl salicylate, ethyl hexyl p-dimethylamino benzoate and ethyl hexyl p-methoxycinnamate) were determined, proving high adsorption capacity and high selectivity for BP4 binding. The highest adsorption capacity was observed for 4-vinylpyridine/ethylene glycol dimethacrylate co-polymer prepared in dimethyl sulfoxide (1.108 mmol g-1). The imprinted polymer with the highest binding capacity was applied to solid phase extraction of BP4 from aqueous solutions with 98.5 % efficiency.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Highly selective water-compatible molecularly imprinted polymers for benzophenone-4: Scientific paper
VL  - 88
IS  - 1
SP  - 55
EP  - 68
DO  - 10.2298/JSC22032540P
ER  - 

@article{
author = "Pešić, Miloš P. and Krstić, Jugoslav and Verbić, Tatjana",
year = "2023",
abstract = "Molecularly imprinting technology was applied for preparing selec­tive sorbents for benzophenone-4 (BP4), an organic UV filter used in sun­screens and cosmetics. Several imprinted polymers were prepared by bulk polymerization, using BP4 as template. Combination of stability (mechanical and chemical), selectivity and robustness of the imprinted polymers with BP4 properties resulted in a successful imprinting process (imprinting factors in range 1.05–2.60). The prepared polymers were characterised by infrared spec­tro­scopy, elemental analysis, conductometric titrations and nitrogen physi­sorp­tion at 77 K. Adsorption capacities and selectivity towards 7 other organic UV filters (benzophenone-3, benzophenone-8, homosalate, butyl methoxydi­ben­zo­ylmethane, ethyl hexyl salicylate, ethyl hexyl p-dimethylamino benzoate and ethyl hexyl p-methoxycinnamate) were determined, proving high adsorption capacity and high selectivity for BP4 binding. The highest adsorption capacity was observed for 4-vinylpyridine/ethylene glycol dimethacrylate co-polymer prepared in dimethyl sulfoxide (1.108 mmol g-1). The imprinted polymer with the highest binding capacity was applied to solid phase extraction of BP4 from aqueous solutions with 98.5 % efficiency.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Highly selective water-compatible molecularly imprinted polymers for benzophenone-4: Scientific paper",
volume = "88",
number = "1",
pages = "55-68",
doi = "10.2298/JSC22032540P"
}

Pešić, M. P., Krstić, J.,& Verbić, T.. (2023). Highly selective water-compatible molecularly imprinted polymers for benzophenone-4: Scientific paper. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 88(1), 55-68.
https://doi.org/10.2298/JSC22032540P

Pešić MP, Krstić J, Verbić T. Highly selective water-compatible molecularly imprinted polymers for benzophenone-4: Scientific paper. in Journal of the Serbian Chemical Society. 2023;88(1):55-68.
doi:10.2298/JSC22032540P .

Pešić, Miloš P., Krstić, Jugoslav, Verbić, Tatjana, "Highly selective water-compatible molecularly imprinted polymers for benzophenone-4: Scientific paper" in Journal of the Serbian Chemical Society, 88, no. 1 (2023):55-68,
https://doi.org/10.2298/JSC22032540P . .

TY  - JOUR
AU  - Đurđić, Slađana
AU  - Vlahović, Filip
AU  - Markićević, Milan
AU  - Mutić, Jelena
AU  - Manojlović, Dragan
AU  - Stanković, Vesna
AU  - Švorc, Ľubomír
AU  - Stanković, Dalibor
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5812
AB  - Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.
PB  - MDPI
T2  - Chemosensors
T1  - Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory
VL  - 11
IS  - 1
SP  - 15
DO  - 10.3390/chemosensors11010015
ER  - 

@article{
author = "Đurđić, Slađana and Vlahović, Filip and Markićević, Milan and Mutić, Jelena and Manojlović, Dragan and Stanković, Vesna and Švorc, Ľubomír and Stanković, Dalibor",
year = "2023",
abstract = "Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.",
publisher = "MDPI",
journal = "Chemosensors",
title = "Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory",
volume = "11",
number = "1",
pages = "15",
doi = "10.3390/chemosensors11010015"
}

Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors
MDPI., 11(1), 15.
https://doi.org/10.3390/chemosensors11010015

Đurđić S, Vlahović F, Markićević M, Mutić J, Manojlović D, Stanković V, Švorc Ľ, Stanković D. Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors. 2023;11(1):15.
doi:10.3390/chemosensors11010015 .

Đurđić, Slađana, Vlahović, Filip, Markićević, Milan, Mutić, Jelena, Manojlović, Dragan, Stanković, Vesna, Švorc, Ľubomír, Stanković, Dalibor, "Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory" in Chemosensors, 11, no. 1 (2023):15,
https://doi.org/10.3390/chemosensors11010015 . .

TY  - JOUR
AU  - Sofrenić, Ivana
AU  - Anđelković, Boban
AU  - Gođevac, Dejan
AU  - Ivanović, Stefan
AU  - Simić, Katarina
AU  - Ljujić, Jovana
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5834
AB  - Chemotaxonomy presents various challenges that need to be overcome in order to obtain valid and reliable results. Individual genetic and environmental variations can give a false picture and lead to wrong conclusions. Applying a holistic approach, based on multivariate data analysis, these challenges can be overcome. Thus, a metabolomics approach has to be optimized depending on the subject of research. We used 1H NMR-based metabolomics as a potential chemotaxonomic tool on the selected Euphorbia species growing wild in Serbia. Principal components analysis (PCA), soft independent modeling by class analogy (SIMCA) and Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) were used to analyze obtained NMR data in order to reveal chemotaxonomic biomarkers. The standard protocol for plant metabolomics was optimized aiming to extract more specific metabolites, which are characteristic for the Euphorbia genus. The obtained models were validated, which revealed that variables unique for each species were associated with certain classes of molecules according to literature data. In E. salicifolia, acacetin-7-O-glycoside (not found before in the species) was detected, and the structure of the aglycone part was solved based on 2D NMR data. In the presented paper, we have shown that metabolomics can be successfully used in Euphorbia chemotaxonomy.
PB  - MDPI
T2  - Plants
T1  - Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia
VL  - 12
IS  - 2
SP  - 262
DO  - 10.3390/plants12020262
ER  - 

@article{
author = "Sofrenić, Ivana and Anđelković, Boban and Gođevac, Dejan and Ivanović, Stefan and Simić, Katarina and Ljujić, Jovana and Tešević, Vele and Milosavljević, Slobodan",
year = "2023",
abstract = "Chemotaxonomy presents various challenges that need to be overcome in order to obtain valid and reliable results. Individual genetic and environmental variations can give a false picture and lead to wrong conclusions. Applying a holistic approach, based on multivariate data analysis, these challenges can be overcome. Thus, a metabolomics approach has to be optimized depending on the subject of research. We used 1H NMR-based metabolomics as a potential chemotaxonomic tool on the selected Euphorbia species growing wild in Serbia. Principal components analysis (PCA), soft independent modeling by class analogy (SIMCA) and Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) were used to analyze obtained NMR data in order to reveal chemotaxonomic biomarkers. The standard protocol for plant metabolomics was optimized aiming to extract more specific metabolites, which are characteristic for the Euphorbia genus. The obtained models were validated, which revealed that variables unique for each species were associated with certain classes of molecules according to literature data. In E. salicifolia, acacetin-7-O-glycoside (not found before in the species) was detected, and the structure of the aglycone part was solved based on 2D NMR data. In the presented paper, we have shown that metabolomics can be successfully used in Euphorbia chemotaxonomy.",
publisher = "MDPI",
journal = "Plants",
title = "Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia",
volume = "12",
number = "2",
pages = "262",
doi = "10.3390/plants12020262"
}

Sofrenić, I., Anđelković, B., Gođevac, D., Ivanović, S., Simić, K., Ljujić, J., Tešević, V.,& Milosavljević, S.. (2023). Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia. in Plants
MDPI., 12(2), 262.
https://doi.org/10.3390/plants12020262

Sofrenić I, Anđelković B, Gođevac D, Ivanović S, Simić K, Ljujić J, Tešević V, Milosavljević S. Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia. in Plants. 2023;12(2):262.
doi:10.3390/plants12020262 .

Sofrenić, Ivana, Anđelković, Boban, Gođevac, Dejan, Ivanović, Stefan, Simić, Katarina, Ljujić, Jovana, Tešević, Vele, Milosavljević, Slobodan, "Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia" in Plants, 12, no. 2 (2023):262,
https://doi.org/10.3390/plants12020262 . .

TY  - JOUR
AU  - Sofrenić, Ivana
AU  - Anđelković, Boban
AU  - Gođevac, Dejan
AU  - Ivanović, Stefan
AU  - Simić, Katarina
AU  - Ljujić, Jovana
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5811
AB  - Chemotaxonomy presents various challenges that need to be overcome in order to obtain valid and reliable results. Individual genetic and environmental variations can give a false picture and lead to wrong conclusions. Applying a holistic approach, based on multivariate data analysis, these challenges can be overcome. Thus, a metabolomics approach has to be optimized depending on the subject of research. We used 1H NMR-based metabolomics as a potential chemotaxonomic tool on the selected Euphorbia species growing wild in Serbia. Principal components analysis (PCA), soft independent modeling by class analogy (SIMCA) and Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) were used to analyze obtained NMR data in order to reveal chemotaxonomic biomarkers. The standard protocol for plant metabolomics was optimized aiming to extract more specific metabolites, which are characteristic for the Euphorbia genus. The obtained models were validated, which revealed that variables unique for each species were associated with certain classes of molecules according to literature data. In E. salicifolia, acacetin-7-O-glycoside (not found before in the species) was detected, and the structure of the aglycone part was solved based on 2D NMR data. In the presented paper, we have shown that metabolomics can be successfully used in Euphorbia chemotaxonomy.
PB  - MDPI
T2  - Plants
T1  - Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia
VL  - 12
IS  - 2
SP  - 262
DO  - 10.3390/plants12020262
ER  - 

@article{
author = "Sofrenić, Ivana and Anđelković, Boban and Gođevac, Dejan and Ivanović, Stefan and Simić, Katarina and Ljujić, Jovana and Tešević, Vele and Milosavljević, Slobodan",
year = "2023",
abstract = "Chemotaxonomy presents various challenges that need to be overcome in order to obtain valid and reliable results. Individual genetic and environmental variations can give a false picture and lead to wrong conclusions. Applying a holistic approach, based on multivariate data analysis, these challenges can be overcome. Thus, a metabolomics approach has to be optimized depending on the subject of research. We used 1H NMR-based metabolomics as a potential chemotaxonomic tool on the selected Euphorbia species growing wild in Serbia. Principal components analysis (PCA), soft independent modeling by class analogy (SIMCA) and Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) were used to analyze obtained NMR data in order to reveal chemotaxonomic biomarkers. The standard protocol for plant metabolomics was optimized aiming to extract more specific metabolites, which are characteristic for the Euphorbia genus. The obtained models were validated, which revealed that variables unique for each species were associated with certain classes of molecules according to literature data. In E. salicifolia, acacetin-7-O-glycoside (not found before in the species) was detected, and the structure of the aglycone part was solved based on 2D NMR data. In the presented paper, we have shown that metabolomics can be successfully used in Euphorbia chemotaxonomy.",
publisher = "MDPI",
journal = "Plants",
title = "Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia",
volume = "12",
number = "2",
pages = "262",
doi = "10.3390/plants12020262"
}

Sofrenić, I., Anđelković, B., Gođevac, D., Ivanović, S., Simić, K., Ljujić, J., Tešević, V.,& Milosavljević, S.. (2023). Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia. in Plants
MDPI., 12(2), 262.
https://doi.org/10.3390/plants12020262

Sofrenić I, Anđelković B, Gođevac D, Ivanović S, Simić K, Ljujić J, Tešević V, Milosavljević S. Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia. in Plants. 2023;12(2):262.
doi:10.3390/plants12020262 .

Sofrenić, Ivana, Anđelković, Boban, Gođevac, Dejan, Ivanović, Stefan, Simić, Katarina, Ljujić, Jovana, Tešević, Vele, Milosavljević, Slobodan, "Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia" in Plants, 12, no. 2 (2023):262,
https://doi.org/10.3390/plants12020262 . .

TY  - JOUR
AU  - Saheed, Ramadan Musbah M.
AU  - Knudsen, Tatjana Šolević
AU  - Faraj, Musbah Abduljalil M.
AU  - Nytoft, Hans Peter
AU  - Jovančićević, Branimir
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5795
AB  - Crude oil samples from the Sharara-C oil field (Concession NC-115, Murzuq Basin, SW Libya) were analysed by organic geochemical methods in order to infer the geochemical characteristics of their respective source rocks. Aromatic hydrocarbons were analysed by gas chromatography – mass spectrometry (GC-MS), and gas chromatography – tandem mass spectrometry (GC-MS-MS) was used to analyse saturated biomarkers. The Sharara-C oils are interpreted to have been generated by marine shales containing mixed terrigenous and marine organic materials deposited in an intermediate (suboxic) environment. Age-specific biomarker ratios indicated that the oils are older than Cretaceous, and maturation-related parameters pointed to their high thermal maturity. Consistent with previous studies, source rocks are inferred to be “hot” shales in the Lower Silurian Tanezzuft Formation. Almost all the parameter ratios calculated varied over a very narrow range, indicating that the investigated oils were compositionally similar. The only significant difference that was noted concerned the sterane/hopane ratios whose variation suggested that there was some variability in the composition of the source organic material. The organic geochemical parameters determined for the Sharara-C crude oils were compared with published data on other crude oils from Concession NC-115. Almost all the parameters agreed well with previously published data on oils from this part of the Murzuq Basin. The greatest deviation concerned the values of some of the maturity parameters. This tended to confirm the conclusions of previous studies concerning the presence of a number of distinct oil families and sub-families in the Sharara oil field area which are genetically related but which have different maturities.
T2  - Journal of Petroleum Geology
T1  - Geochemical Characteristics of Crude Oils from the Sharara-C Oil Field, Murzuq Basin, Southwestern Libya
VL  - 46
IS  - 1
SP  - 103
EP  - 123
DO  - 10.1111/jpg.12832
ER  - 

@article{
author = "Saheed, Ramadan Musbah M. and Knudsen, Tatjana Šolević and Faraj, Musbah Abduljalil M. and Nytoft, Hans Peter and Jovančićević, Branimir",
year = "2023",
abstract = "Crude oil samples from the Sharara-C oil field (Concession NC-115, Murzuq Basin, SW Libya) were analysed by organic geochemical methods in order to infer the geochemical characteristics of their respective source rocks. Aromatic hydrocarbons were analysed by gas chromatography – mass spectrometry (GC-MS), and gas chromatography – tandem mass spectrometry (GC-MS-MS) was used to analyse saturated biomarkers. The Sharara-C oils are interpreted to have been generated by marine shales containing mixed terrigenous and marine organic materials deposited in an intermediate (suboxic) environment. Age-specific biomarker ratios indicated that the oils are older than Cretaceous, and maturation-related parameters pointed to their high thermal maturity. Consistent with previous studies, source rocks are inferred to be “hot” shales in the Lower Silurian Tanezzuft Formation. Almost all the parameter ratios calculated varied over a very narrow range, indicating that the investigated oils were compositionally similar. The only significant difference that was noted concerned the sterane/hopane ratios whose variation suggested that there was some variability in the composition of the source organic material. The organic geochemical parameters determined for the Sharara-C crude oils were compared with published data on other crude oils from Concession NC-115. Almost all the parameters agreed well with previously published data on oils from this part of the Murzuq Basin. The greatest deviation concerned the values of some of the maturity parameters. This tended to confirm the conclusions of previous studies concerning the presence of a number of distinct oil families and sub-families in the Sharara oil field area which are genetically related but which have different maturities.",
journal = "Journal of Petroleum Geology",
title = "Geochemical Characteristics of Crude Oils from the Sharara-C Oil Field, Murzuq Basin, Southwestern Libya",
volume = "46",
number = "1",
pages = "103-123",
doi = "10.1111/jpg.12832"
}

Saheed, R. M. M., Knudsen, T. Š., Faraj, M. A. M., Nytoft, H. P.,& Jovančićević, B.. (2023). Geochemical Characteristics of Crude Oils from the Sharara-C Oil Field, Murzuq Basin, Southwestern Libya. in Journal of Petroleum Geology, 46(1), 103-123.
https://doi.org/10.1111/jpg.12832

Saheed RMM, Knudsen TŠ, Faraj MAM, Nytoft HP, Jovančićević B. Geochemical Characteristics of Crude Oils from the Sharara-C Oil Field, Murzuq Basin, Southwestern Libya. in Journal of Petroleum Geology. 2023;46(1):103-123.
doi:10.1111/jpg.12832 .

Saheed, Ramadan Musbah M., Knudsen, Tatjana Šolević, Faraj, Musbah Abduljalil M., Nytoft, Hans Peter, Jovančićević, Branimir, "Geochemical Characteristics of Crude Oils from the Sharara-C Oil Field, Murzuq Basin, Southwestern Libya" in Journal of Petroleum Geology, 46, no. 1 (2023):103-123,
https://doi.org/10.1111/jpg.12832 . .

TY  - JOUR
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Andrić, Deana
AU  - Suručić, Relja
AU  - Kostić-Rajačić, Slađana
PY  - 2022
UR  - http://www.ncbi.nlm.nih.gov/pubmed/35507251
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5181
AB  - Adrenergic receptors are among the most studied G protein-coupled receptors. Activation or blockade of these receptors is a major therapeutic approach for the treatment of numerous disorders such as cardiac hypertrophy, congestive heart failure, hypertension, angina pectoris, cardiac arrhythmias, depression, benign prostate hyperplasia, anaphylaxis, asthma, and hyperthyroidism. Among all nine cloned adrenoceptor subtypes and the subsequent development of animal models, a significant target for various neurological conditions treatment is alpha1-adrenergic receptors. 2-{[4-(2-Methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles, their 5 substituted derivatives, and structurally similar, arylpiperazine based alpha1-adrenergic receptors antagonists (trazodone, naftopidil, and urapidil) have been subjects of comparative analysis. Most of the novel compounds showed alpha1-adrenergic affinity in the range from 22 nM to 250 nM. The in silico docking and molecular dynamics simulations, binding data together with absorption, distribution, metabolism, and excretion (ADME) calculations identified the promising lead compounds. The results brought out the conclusions which allowed us to propose a rationale for the activity of these molecules and to highlight six compounds (2-5, 8, and 12) that exhibited an acceptable pharmacokinetic profile to the advanced investigation as the potential alpha1-adrenergic receptor antagonists.
PB  - Springer
T2  - Applied Biochemistry and Biotechnology
T1  - The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study
VL  - 194
SP  - 3749
EP  - 3764
DO  - 10.1007/s12010-022-03922-8
ER  - 

@article{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Andrić, Deana and Suručić, Relja and Kostić-Rajačić, Slađana",
year = "2022",
abstract = "Adrenergic receptors are among the most studied G protein-coupled receptors. Activation or blockade of these receptors is a major therapeutic approach for the treatment of numerous disorders such as cardiac hypertrophy, congestive heart failure, hypertension, angina pectoris, cardiac arrhythmias, depression, benign prostate hyperplasia, anaphylaxis, asthma, and hyperthyroidism. Among all nine cloned adrenoceptor subtypes and the subsequent development of animal models, a significant target for various neurological conditions treatment is alpha1-adrenergic receptors. 2-{[4-(2-Methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles, their 5 substituted derivatives, and structurally similar, arylpiperazine based alpha1-adrenergic receptors antagonists (trazodone, naftopidil, and urapidil) have been subjects of comparative analysis. Most of the novel compounds showed alpha1-adrenergic affinity in the range from 22 nM to 250 nM. The in silico docking and molecular dynamics simulations, binding data together with absorption, distribution, metabolism, and excretion (ADME) calculations identified the promising lead compounds. The results brought out the conclusions which allowed us to propose a rationale for the activity of these molecules and to highlight six compounds (2-5, 8, and 12) that exhibited an acceptable pharmacokinetic profile to the advanced investigation as the potential alpha1-adrenergic receptor antagonists.",
publisher = "Springer",
journal = "Applied Biochemistry and Biotechnology",
title = "The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study",
volume = "194",
pages = "3749-3764",
doi = "10.1007/s12010-022-03922-8"
}

Penjišević, J., Šukalović, V., Andrić, D., Suručić, R.,& Kostić-Rajačić, S.. (2022). The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study. in Applied Biochemistry and Biotechnology
Springer., 194, 3749-3764.
https://doi.org/10.1007/s12010-022-03922-8

Penjišević J, Šukalović V, Andrić D, Suručić R, Kostić-Rajačić S. The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study. in Applied Biochemistry and Biotechnology. 2022;194:3749-3764.
doi:10.1007/s12010-022-03922-8 .

Penjišević, Jelena , Šukalović, Vladimir , Andrić, Deana, Suručić, Relja, Kostić-Rajačić, Slađana, "The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study" in Applied Biochemistry and Biotechnology, 194 (2022):3749-3764,
https://doi.org/10.1007/s12010-022-03922-8 . .

TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Andrić, Deana
AU  - Suručić, Relja
AU  - Kostić-Rajačić, Slađana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5182
AB  - Adrenergic receptors are among the most studied G protein-coupled receptors. Activation or blockade of these receptors is a major therapeutic approach for the treatment of numerous disorders such as cardiac hypertrophy, congestive heart failure, hypertension, angina pectoris, cardiac arrhythmias, depression, benign prostate hyperplasia, anaphylaxis, asthma, and hyperthyroidism. Among all nine cloned adrenoceptor subtypes and the subsequent development of animal models, a significant target for various neurological conditions treatment is alpha1-adrenergic receptors. 2-{[4-(2-Methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles, their 5 substituted derivatives, and structurally similar, arylpiperazine based alpha1-adrenergic receptors antagonists (trazodone, naftopidil, and urapidil) have been subjects of comparative analysis. Most of the novel compounds showed alpha1-adrenergic affinity in the range from 22 nM to 250 nM. The in silico docking and molecular dynamics simulations, binding data together with absorption, distribution, metabolism, and excretion (ADME) calculations identified the promising lead compounds. The results brought out the conclusions which allowed us to propose a rationale for the activity of these molecules and to highlight six compounds (2-5, 8, and 12) that exhibited an acceptable pharmacokinetic profile to the advanced investigation as the potential alpha1-adrenergic receptor antagonists.
PB  - Springer
T2  - Applied Biochemistry and Biotechnology
T1  - Supplementary information for the article: Penjišević, J. Z.; Šukalović, V. B.; Andrić, D. B.; Suručić, R.; Kostić-Rajačić, S. V. The Therapeutic Potential of 2-{[4-(2-Methoxyphenyl)Piperazin-1-Yl]Alkyl}-1H-Benzo[d]Imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study. Applied Biochemistry and Biotechnology 2022. https://doi.org/10.1007/s12010-022-03922-8.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5182
ER  - 

@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Andrić, Deana and Suručić, Relja and Kostić-Rajačić, Slađana",
year = "2022",
abstract = "Adrenergic receptors are among the most studied G protein-coupled receptors. Activation or blockade of these receptors is a major therapeutic approach for the treatment of numerous disorders such as cardiac hypertrophy, congestive heart failure, hypertension, angina pectoris, cardiac arrhythmias, depression, benign prostate hyperplasia, anaphylaxis, asthma, and hyperthyroidism. Among all nine cloned adrenoceptor subtypes and the subsequent development of animal models, a significant target for various neurological conditions treatment is alpha1-adrenergic receptors. 2-{[4-(2-Methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles, their 5 substituted derivatives, and structurally similar, arylpiperazine based alpha1-adrenergic receptors antagonists (trazodone, naftopidil, and urapidil) have been subjects of comparative analysis. Most of the novel compounds showed alpha1-adrenergic affinity in the range from 22 nM to 250 nM. The in silico docking and molecular dynamics simulations, binding data together with absorption, distribution, metabolism, and excretion (ADME) calculations identified the promising lead compounds. The results brought out the conclusions which allowed us to propose a rationale for the activity of these molecules and to highlight six compounds (2-5, 8, and 12) that exhibited an acceptable pharmacokinetic profile to the advanced investigation as the potential alpha1-adrenergic receptor antagonists.",
publisher = "Springer",
journal = "Applied Biochemistry and Biotechnology",
title = "Supplementary information for the article: Penjišević, J. Z.; Šukalović, V. B.; Andrić, D. B.; Suručić, R.; Kostić-Rajačić, S. V. The Therapeutic Potential of 2-{[4-(2-Methoxyphenyl)Piperazin-1-Yl]Alkyl}-1H-Benzo[d]Imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study. Applied Biochemistry and Biotechnology 2022. https://doi.org/10.1007/s12010-022-03922-8.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5182"
}

Penjišević, J., Šukalović, V., Andrić, D., Suručić, R.,& Kostić-Rajačić, S.. (2022). Supplementary information for the article: Penjišević, J. Z.; Šukalović, V. B.; Andrić, D. B.; Suručić, R.; Kostić-Rajačić, S. V. The Therapeutic Potential of 2-{[4-(2-Methoxyphenyl)Piperazin-1-Yl]Alkyl}-1H-Benzo[d]Imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study. Applied Biochemistry and Biotechnology 2022. https://doi.org/10.1007/s12010-022-03922-8.. in Applied Biochemistry and Biotechnology
Springer..
https://hdl.handle.net/21.15107/rcub_cherry_5182

Penjišević J, Šukalović V, Andrić D, Suručić R, Kostić-Rajačić S. Supplementary information for the article: Penjišević, J. Z.; Šukalović, V. B.; Andrić, D. B.; Suručić, R.; Kostić-Rajačić, S. V. The Therapeutic Potential of 2-{[4-(2-Methoxyphenyl)Piperazin-1-Yl]Alkyl}-1H-Benzo[d]Imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study. Applied Biochemistry and Biotechnology 2022. https://doi.org/10.1007/s12010-022-03922-8.. in Applied Biochemistry and Biotechnology. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_5182 .

Penjišević, Jelena , Šukalović, Vladimir , Andrić, Deana, Suručić, Relja, Kostić-Rajačić, Slađana, "Supplementary information for the article: Penjišević, J. Z.; Šukalović, V. B.; Andrić, D. B.; Suručić, R.; Kostić-Rajačić, S. V. The Therapeutic Potential of 2-{[4-(2-Methoxyphenyl)Piperazin-1-Yl]Alkyl}-1H-Benzo[d]Imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study. Applied Biochemistry and Biotechnology 2022. https://doi.org/10.1007/s12010-022-03922-8." in Applied Biochemistry and Biotechnology (2022),
https://hdl.handle.net/21.15107/rcub_cherry_5182 .

TY  - JOUR
AU  - Šegan, Sandra B.
AU  - Jevtić, Ivana
AU  - Tosti, Tomislav
AU  - Penjišević, Jelena
AU  - Šukalović, Vladimir
AU  - Kostić-Rajačić, Slađana
AU  - Milojković-Opsenica, Dušanka
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5649
AB  - Lipophilicity and ionization constant of sixteen fentanyl analogues were investigated by reversed-phase thin-
layer chromatography (RP-TLC). Fourteen compounds have nitrogen containing groups at C-3 position of the
piperidine ring and two compounds are 3-carbomethoxy derivatives of fentanyl. Among them, five are diaste-
reomeric cis/trans couples and six novel trans diastereomers. In addition, the lipophilicity and ionization constant
of fentanyl were also determined by the same method, as a reference. The physicochemical property, lip-
ophilicity, expressed as retention indices RM
0 , b, and C0, as well as PC1, was determined and correlated with in
silico values. Ionization constants were determined on the basis of the relationships between analyte’s retention
expressed as RF and mobile phase pH. Calculated structural descriptors together with the retention indices, were
subjected to the principal component analysis – PCA and hierarchical cluster analysis – HCA, in order to provide
basic insights into the similarities among the studied compounds. The blood – brain barrier (BBB) permeation
was investigated in the function of experimentally obtained values of lipophilicity, polar surface area and mo-
lecular weight. In general, results of the present research corroborate well with previously determined anti-
nociceptive activities of the investigated compounds, pointing out that besides the cis/trans isomerism, another
set of important parameters should be taken into account when designing new derivatives of C-3 substituted
fentanyl, especially lipophilicity, voluminosity and HBD/A character of the substituents. Accordingly, RP-TLC
can be considered as a valuable asset in the ligand-based drug design
PB  - Elsevier
T2  - Journal of Chromatography B
T1  - Determination of lipophilicity and ionization of fentanyl and its 3‑substituted analogs by reversed-phase thin-layer chromatography
VL  - 1211
SP  - 123481
DO  - 10.1016/j.jchromb.2022.123481
ER  - 

@article{
author = "Šegan, Sandra B. and Jevtić, Ivana and Tosti, Tomislav and Penjišević, Jelena and Šukalović, Vladimir and Kostić-Rajačić, Slađana and Milojković-Opsenica, Dušanka",
year = "2022",
abstract = "Lipophilicity and ionization constant of sixteen fentanyl analogues were investigated by reversed-phase thin-
layer chromatography (RP-TLC). Fourteen compounds have nitrogen containing groups at C-3 position of the
piperidine ring and two compounds are 3-carbomethoxy derivatives of fentanyl. Among them, five are diaste-
reomeric cis/trans couples and six novel trans diastereomers. In addition, the lipophilicity and ionization constant
of fentanyl were also determined by the same method, as a reference. The physicochemical property, lip-
ophilicity, expressed as retention indices RM
0 , b, and C0, as well as PC1, was determined and correlated with in
silico values. Ionization constants were determined on the basis of the relationships between analyte’s retention
expressed as RF and mobile phase pH. Calculated structural descriptors together with the retention indices, were
subjected to the principal component analysis – PCA and hierarchical cluster analysis – HCA, in order to provide
basic insights into the similarities among the studied compounds. The blood – brain barrier (BBB) permeation
was investigated in the function of experimentally obtained values of lipophilicity, polar surface area and mo-
lecular weight. In general, results of the present research corroborate well with previously determined anti-
nociceptive activities of the investigated compounds, pointing out that besides the cis/trans isomerism, another
set of important parameters should be taken into account when designing new derivatives of C-3 substituted
fentanyl, especially lipophilicity, voluminosity and HBD/A character of the substituents. Accordingly, RP-TLC
can be considered as a valuable asset in the ligand-based drug design",
publisher = "Elsevier",
journal = "Journal of Chromatography B",
title = "Determination of lipophilicity and ionization of fentanyl and its 3‑substituted analogs by reversed-phase thin-layer chromatography",
volume = "1211",
pages = "123481",
doi = "10.1016/j.jchromb.2022.123481"
}

Šegan, S. B., Jevtić, I., Tosti, T., Penjišević, J., Šukalović, V., Kostić-Rajačić, S.,& Milojković-Opsenica, D.. (2022). Determination of lipophilicity and ionization of fentanyl and its 3‑substituted analogs by reversed-phase thin-layer chromatography. in Journal of Chromatography B
Elsevier., 1211, 123481.
https://doi.org/10.1016/j.jchromb.2022.123481

Šegan SB, Jevtić I, Tosti T, Penjišević J, Šukalović V, Kostić-Rajačić S, Milojković-Opsenica D. Determination of lipophilicity and ionization of fentanyl and its 3‑substituted analogs by reversed-phase thin-layer chromatography. in Journal of Chromatography B. 2022;1211:123481.
doi:10.1016/j.jchromb.2022.123481 .

Šegan, Sandra B., Jevtić, Ivana, Tosti, Tomislav, Penjišević, Jelena, Šukalović, Vladimir, Kostić-Rajačić, Slađana, Milojković-Opsenica, Dušanka, "Determination of lipophilicity and ionization of fentanyl and its 3‑substituted analogs by reversed-phase thin-layer chromatography" in Journal of Chromatography B, 1211 (2022):123481,
https://doi.org/10.1016/j.jchromb.2022.123481 . .

TY  - DATA
AU  - Šegan, Sandra B.
AU  - Jevtić, Ivana
AU  - Tosti, Tomislav
AU  - Penjišević, Jelena
AU  - Šukalović, Vladimir
AU  - Kostić-Rajačić, Slađana
AU  - Milojković-Opsenica, Dušanka
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5650
AB  - Lipophilicity and ionization constant of sixteen fentanyl analogues were investigated by reversed-phase thin-layer chromatography (RP-TLC). Fourteen compounds have nitrogen containing groups at C-3 position of thepiperidine ring and two compounds are 3-carbomethoxy derivatives of fentanyl. Among them, five are diaste-reomeric cis/trans couples and six novel trans diastereomers. In addition, the lipophilicity and ionization constantof fentanyl were also determined by the same method, as a reference. The physicochemical property, lip-ophilicity, expressed as retention indices RM0 , b, and C0, as well as PC1, was determined and correlated with insilico values. Ionization constants were determined on the basis of the relationships between analyte’s retentionexpressed as RF and mobile phase pH. Calculated structural descriptors together with the retention indices, weresubjected to the principal component analysis – PCA and hierarchical cluster analysis – HCA, in order to providebasic insights into the similarities among the studied compounds. The blood – brain barrier (BBB) permeationwas investigated in the function of experimentally obtained values of lipophilicity, polar surface area and mo-lecular weight. In general, results of the present research corroborate well with previously determined anti-nociceptive activities of the investigated compounds, pointing out that besides the cis/trans isomerism, anotherset of important parameters should be taken into account when designing new derivatives of C-3 substitutedfentanyl, especially lipophilicity, voluminosity and HBD/A character of the substituents. Accordingly, RP-TLCcan be considered as a valuable asset in the ligand-based drug design
PB  - Elsevier
T2  - Journal of Chromatography B
T1  - Supplementary material for: Šegan, S., Jevtić, I., Tosti, T., Penjišević, J., Šukalović, V., Kostić-Rajačić, S.,& Milojković-Opsenica, D.. (2022). Determination of lipophilicity and ionization of fentanyl and its 3‑substituted analogs by reversed-phase thin-layer chromatography. in Journal of Chromatography B Elsevier., 1211, 123481. https://doi.org/10.1016/j.jchromb.2022.123481
VL  - 1211
SP  - 123481
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5650
ER  - 

@misc{
author = "Šegan, Sandra B. and Jevtić, Ivana and Tosti, Tomislav and Penjišević, Jelena and Šukalović, Vladimir and Kostić-Rajačić, Slađana and Milojković-Opsenica, Dušanka",
year = "2022",
abstract = "Lipophilicity and ionization constant of sixteen fentanyl analogues were investigated by reversed-phase thin-layer chromatography (RP-TLC). Fourteen compounds have nitrogen containing groups at C-3 position of thepiperidine ring and two compounds are 3-carbomethoxy derivatives of fentanyl. Among them, five are diaste-reomeric cis/trans couples and six novel trans diastereomers. In addition, the lipophilicity and ionization constantof fentanyl were also determined by the same method, as a reference. The physicochemical property, lip-ophilicity, expressed as retention indices RM0 , b, and C0, as well as PC1, was determined and correlated with insilico values. Ionization constants were determined on the basis of the relationships between analyte’s retentionexpressed as RF and mobile phase pH. Calculated structural descriptors together with the retention indices, weresubjected to the principal component analysis – PCA and hierarchical cluster analysis – HCA, in order to providebasic insights into the similarities among the studied compounds. The blood – brain barrier (BBB) permeationwas investigated in the function of experimentally obtained values of lipophilicity, polar surface area and mo-lecular weight. In general, results of the present research corroborate well with previously determined anti-nociceptive activities of the investigated compounds, pointing out that besides the cis/trans isomerism, anotherset of important parameters should be taken into account when designing new derivatives of C-3 substitutedfentanyl, especially lipophilicity, voluminosity and HBD/A character of the substituents. Accordingly, RP-TLCcan be considered as a valuable asset in the ligand-based drug design",
publisher = "Elsevier",
journal = "Journal of Chromatography B",
title = "Supplementary material for: Šegan, S., Jevtić, I., Tosti, T., Penjišević, J., Šukalović, V., Kostić-Rajačić, S.,& Milojković-Opsenica, D.. (2022). Determination of lipophilicity and ionization of fentanyl and its 3‑substituted analogs by reversed-phase thin-layer chromatography. in Journal of Chromatography B Elsevier., 1211, 123481. https://doi.org/10.1016/j.jchromb.2022.123481",
volume = "1211",
pages = "123481",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5650"
}

Šegan, S. B., Jevtić, I., Tosti, T., Penjišević, J., Šukalović, V., Kostić-Rajačić, S.,& Milojković-Opsenica, D.. (2022). Supplementary material for: Šegan, S., Jevtić, I., Tosti, T., Penjišević, J., Šukalović, V., Kostić-Rajačić, S.,& Milojković-Opsenica, D.. (2022). Determination of lipophilicity and ionization of fentanyl and its 3‑substituted analogs by reversed-phase thin-layer chromatography. in Journal of Chromatography B Elsevier., 1211, 123481. https://doi.org/10.1016/j.jchromb.2022.123481. in Journal of Chromatography B
Elsevier., 1211, 123481.
https://hdl.handle.net/21.15107/rcub_cherry_5650

Šegan SB, Jevtić I, Tosti T, Penjišević J, Šukalović V, Kostić-Rajačić S, Milojković-Opsenica D. Supplementary material for: Šegan, S., Jevtić, I., Tosti, T., Penjišević, J., Šukalović, V., Kostić-Rajačić, S.,& Milojković-Opsenica, D.. (2022). Determination of lipophilicity and ionization of fentanyl and its 3‑substituted analogs by reversed-phase thin-layer chromatography. in Journal of Chromatography B Elsevier., 1211, 123481. https://doi.org/10.1016/j.jchromb.2022.123481. in Journal of Chromatography B. 2022;1211:123481.
https://hdl.handle.net/21.15107/rcub_cherry_5650 .

Šegan, Sandra B., Jevtić, Ivana, Tosti, Tomislav, Penjišević, Jelena, Šukalović, Vladimir, Kostić-Rajačić, Slađana, Milojković-Opsenica, Dušanka, "Supplementary material for: Šegan, S., Jevtić, I., Tosti, T., Penjišević, J., Šukalović, V., Kostić-Rajačić, S.,& Milojković-Opsenica, D.. (2022). Determination of lipophilicity and ionization of fentanyl and its 3‑substituted analogs by reversed-phase thin-layer chromatography. in Journal of Chromatography B Elsevier., 1211, 123481. https://doi.org/10.1016/j.jchromb.2022.123481" in Journal of Chromatography B, 1211 (2022):123481,
https://hdl.handle.net/21.15107/rcub_cherry_5650 .

TY  - JOUR
AU  - Stevanović, Nevena
AU  - Zlatar, Matija
AU  - Novaković, Irena T.
AU  - Pevec, Andrej
AU  - Radanović, Dušanka D.
AU  - Matić, Ivana Z.
AU  - Đorđić Crnogorac, Marija
AU  - Stanojković, Tatjana
AU  - Vujčić, Miroslava
AU  - Gruden, Maja
AU  - Sladić, Dušan
AU  - Anđelković, Katarina K.
AU  - Turel, Iztok
AU  - Čobeljić, Božidar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4857
AB  - In this paper, Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and DFT calculations. In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear penta-coordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], respectively, while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-negative and Gram-positive bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin.
PB  - Royal Society of Chemistry (RSC)
T2  - Dalton Transactions
T1  - Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity
VL  - 51
IS  - 1
SP  - 185
EP  - 196
DO  - 10.1039/D1DT03169D
ER  - 

@article{
author = "Stevanović, Nevena and Zlatar, Matija and Novaković, Irena T. and Pevec, Andrej and Radanović, Dušanka D. and Matić, Ivana Z. and Đorđić Crnogorac, Marija and Stanojković, Tatjana and Vujčić, Miroslava and Gruden, Maja and Sladić, Dušan and Anđelković, Katarina K. and Turel, Iztok and Čobeljić, Božidar",
year = "2022",
abstract = "In this paper, Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and DFT calculations. In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear penta-coordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], respectively, while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-negative and Gram-positive bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin.",
publisher = "Royal Society of Chemistry (RSC)",
journal = "Dalton Transactions",
title = "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity",
volume = "51",
number = "1",
pages = "185-196",
doi = "10.1039/D1DT03169D"
}

Stevanović, N., Zlatar, M., Novaković, I. T., Pevec, A., Radanović, D. D., Matić, I. Z., Đorđić Crnogorac, M., Stanojković, T., Vujčić, M., Gruden, M., Sladić, D., Anđelković, K. K., Turel, I.,& Čobeljić, B.. (2022). Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity. in Dalton Transactions
Royal Society of Chemistry (RSC)., 51(1), 185-196.
https://doi.org/10.1039/D1DT03169D

Stevanović N, Zlatar M, Novaković IT, Pevec A, Radanović DD, Matić IZ, Đorđić Crnogorac M, Stanojković T, Vujčić M, Gruden M, Sladić D, Anđelković KK, Turel I, Čobeljić B. Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity. in Dalton Transactions. 2022;51(1):185-196.
doi:10.1039/D1DT03169D .

Stevanović, Nevena, Zlatar, Matija, Novaković, Irena T., Pevec, Andrej, Radanović, Dušanka D., Matić, Ivana Z., Đorđić Crnogorac, Marija, Stanojković, Tatjana, Vujčić, Miroslava, Gruden, Maja, Sladić, Dušan, Anđelković, Katarina K., Turel, Iztok, Čobeljić, Božidar, "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity" in Dalton Transactions, 51, no. 1 (2022):185-196,
https://doi.org/10.1039/D1DT03169D . .

TY  - DATA
AU  - Stevanović, Nevena
AU  - Zlatar, Matija
AU  - Novaković, Irena T.
AU  - Pevec, Andrej
AU  - Radanović, Dušanka D.
AU  - Matić, Ivana Z.
AU  - Đorđić Crnogorac, Marija
AU  - Stanojković, Tatjana
AU  - Vujčić, Miroslava
AU  - Gruden, Maja
AU  - Sladić, Dušan
AU  - Anđelković, Katarina K.
AU  - Turel, Iztok
AU  - Čobeljić, Božidar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4858
AB  - In this paper, Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and DFT calculations. In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear penta-coordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], respectively, while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-negative and Gram-positive bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin.
PB  - Royal Society of Chemistry (RSC)
T2  - Dalton Transactions
T1  - Supporting information for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4858
ER  - 

@misc{
author = "Stevanović, Nevena and Zlatar, Matija and Novaković, Irena T. and Pevec, Andrej and Radanović, Dušanka D. and Matić, Ivana Z. and Đorđić Crnogorac, Marija and Stanojković, Tatjana and Vujčić, Miroslava and Gruden, Maja and Sladić, Dušan and Anđelković, Katarina K. and Turel, Iztok and Čobeljić, Božidar",
year = "2022",
abstract = "In this paper, Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and DFT calculations. In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear penta-coordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], respectively, while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-negative and Gram-positive bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin.",
publisher = "Royal Society of Chemistry (RSC)",
journal = "Dalton Transactions",
title = "Supporting information for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4858"
}

Stevanović, N., Zlatar, M., Novaković, I. T., Pevec, A., Radanović, D. D., Matić, I. Z., Đorđić Crnogorac, M., Stanojković, T., Vujčić, M., Gruden, M., Sladić, D., Anđelković, K. K., Turel, I.,& Čobeljić, B.. (2022). Supporting information for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". in Dalton Transactions
Royal Society of Chemistry (RSC)..
https://hdl.handle.net/21.15107/rcub_cherry_4858

Stevanović N, Zlatar M, Novaković IT, Pevec A, Radanović DD, Matić IZ, Đorđić Crnogorac M, Stanojković T, Vujčić M, Gruden M, Sladić D, Anđelković KK, Turel I, Čobeljić B. Supporting information for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". in Dalton Transactions. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_4858 .

Stevanović, Nevena, Zlatar, Matija, Novaković, Irena T., Pevec, Andrej, Radanović, Dušanka D., Matić, Ivana Z., Đorđić Crnogorac, Marija, Stanojković, Tatjana, Vujčić, Miroslava, Gruden, Maja, Sladić, Dušan, Anđelković, Katarina K., Turel, Iztok, Čobeljić, Božidar, "Supporting information for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"" in Dalton Transactions (2022),
https://hdl.handle.net/21.15107/rcub_cherry_4858 .

TY  - DATA
AU  - Pevec, Andrej
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4859
AB  - NAMYIN : azido-[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-(methanol)-copper tetrafluoroborate Space Group: P 21/n (14), Cell: a 7.0033(3)Å b 10.8941(3)Å c 25.6059(9)Å, α 90° β 97.242(4)° γ 90°
PB  - The Cambridge Crystallographic Data Centre (CCDC)
T1  - CCDC 2110386: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"
DO  - 10.5517/ccdc.csd.cc28v0z4
ER  - 

@misc{
author = "Pevec, Andrej",
year = "2022",
abstract = "NAMYIN : azido-[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-(methanol)-copper tetrafluoroborate Space Group: P 21/n (14), Cell: a 7.0033(3)Å b 10.8941(3)Å c 25.6059(9)Å, α 90° β 97.242(4)° γ 90°",
publisher = "The Cambridge Crystallographic Data Centre (CCDC)",
title = "CCDC 2110386: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"",
doi = "10.5517/ccdc.csd.cc28v0z4"
}

Pevec, A.. (2022). CCDC 2110386: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 
The Cambridge Crystallographic Data Centre (CCDC)..
https://doi.org/10.5517/ccdc.csd.cc28v0z4

Pevec A. CCDC 2110386: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 2022;.
doi:10.5517/ccdc.csd.cc28v0z4 .

Pevec, Andrej, "CCDC 2110386: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"" (2022),
https://doi.org/10.5517/ccdc.csd.cc28v0z4 . .

TY  - DATA
AU  - Pevec, Andrej
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4860
AB  - NAMYOT : bis(μ-azido)-diazido-bis[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-di-manganese methanol solvate Space Group: P 1 (2), Cell: a 9.6427(5)Å b 10.8396(5)Å c 10.8617(8)Å, α 106.971(5)° β 103.497(5)° γ 112.469(5)°
PB  - The Cambridge Crystallographic Data Centre (CCDC)
T1  - CCDC 2110387: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"
DO  - 10.5517/ccdc.csd.cc28v106
ER  - 

@misc{
author = "Pevec, Andrej",
year = "2022",
abstract = "NAMYOT : bis(μ-azido)-diazido-bis[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-di-manganese methanol solvate Space Group: P 1 (2), Cell: a 9.6427(5)Å b 10.8396(5)Å c 10.8617(8)Å, α 106.971(5)° β 103.497(5)° γ 112.469(5)°",
publisher = "The Cambridge Crystallographic Data Centre (CCDC)",
title = "CCDC 2110387: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"",
doi = "10.5517/ccdc.csd.cc28v106"
}

Pevec, A.. (2022). CCDC 2110387: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 
The Cambridge Crystallographic Data Centre (CCDC)..
https://doi.org/10.5517/ccdc.csd.cc28v106

Pevec A. CCDC 2110387: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 2022;.
doi:10.5517/ccdc.csd.cc28v106 .

Pevec, Andrej, "CCDC 2110387: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"" (2022),
https://doi.org/10.5517/ccdc.csd.cc28v106 . .

TY  - DATA
AU  - Pevec, Andrej
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4861
AB  - NAMYUZ : diazido-[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-zinc Space Group: P 21/c (14), Cell: a 13.0826(10)Å b 10.2506(7)Å c 13.1685(13)Å, α 90° β 111.237(10)° γ 90°
PB  - The Cambridge Crystallographic Data Centre (CCDC)
T1  - CCDC 2110388: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"
DO  - 10.5517/ccdc.csd.cc28v117
ER  - 

@misc{
author = "Pevec, Andrej",
year = "2022",
abstract = "NAMYUZ : diazido-[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-zinc Space Group: P 21/c (14), Cell: a 13.0826(10)Å b 10.2506(7)Å c 13.1685(13)Å, α 90° β 111.237(10)° γ 90°",
publisher = "The Cambridge Crystallographic Data Centre (CCDC)",
title = "CCDC 2110388: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"",
doi = "10.5517/ccdc.csd.cc28v117"
}

Pevec, A.. (2022). CCDC 2110388: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 
The Cambridge Crystallographic Data Centre (CCDC)..
https://doi.org/10.5517/ccdc.csd.cc28v117

Pevec A. CCDC 2110388: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 2022;.
doi:10.5517/ccdc.csd.cc28v117 .

Pevec, Andrej, "CCDC 2110388: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"" (2022),
https://doi.org/10.5517/ccdc.csd.cc28v117 . .

TY  - JOUR
AU  - Stevanović, Nevena
AU  - Jevtović, Mima
AU  - Mitić, Dragana
AU  - Matić, Ivana Z.
AU  - Crnogorac, Marija Đ.
AU  - Vujčić, Miroslava
AU  - Sladić, Dušan
AU  - Čobeljić, Božidar
AU  - Anđelković, Katarina K.
PY  - 2022
UR  - http://www.doiserbia.nb.rs/img/doi/0352-5139/2022/0352-51392202181S.pdf
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5154
AB  - In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.
PB  - Beograd : Srpsko hemijsko društvo
T2  - Journal of the Serbian Chemical Society
T1  - Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent
VL  - 87
IS  - 2
SP  - 181
EP  - 192
DO  - 10.2298/JSC211203114S
ER  - 

@article{
author = "Stevanović, Nevena and Jevtović, Mima and Mitić, Dragana and Matić, Ivana Z. and Crnogorac, Marija Đ. and Vujčić, Miroslava and Sladić, Dušan and Čobeljić, Božidar and Anđelković, Katarina K.",
year = "2022",
abstract = "In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "Journal of the Serbian Chemical Society",
title = "Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent",
volume = "87",
number = "2",
pages = "181-192",
doi = "10.2298/JSC211203114S"
}

Stevanović, N., Jevtović, M., Mitić, D., Matić, I. Z., Crnogorac, M. Đ., Vujčić, M., Sladić, D., Čobeljić, B.,& Anđelković, K. K.. (2022). Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent. in Journal of the Serbian Chemical Society
Beograd : Srpsko hemijsko društvo., 87(2), 181-192.
https://doi.org/10.2298/JSC211203114S

Stevanović N, Jevtović M, Mitić D, Matić IZ, Crnogorac MĐ, Vujčić M, Sladić D, Čobeljić B, Anđelković KK. Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent. in Journal of the Serbian Chemical Society. 2022;87(2):181-192.
doi:10.2298/JSC211203114S .

Stevanović, Nevena, Jevtović, Mima, Mitić, Dragana, Matić, Ivana Z., Crnogorac, Marija Đ., Vujčić, Miroslava, Sladić, Dušan, Čobeljić, Božidar, Anđelković, Katarina K., "Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent" in Journal of the Serbian Chemical Society, 87, no. 2 (2022):181-192,
https://doi.org/10.2298/JSC211203114S . .

TY  - DATA
AU  - Stevanović, Nevena
AU  - Jevtović, Mima
AU  - Mitić, Dragana
AU  - Matić, Ivana Z.
AU  - Crnogorac, Marija Đ.
AU  - Vujčić, Miroslava
AU  - Sladić, Dušan
AU  - Čobeljić, Božidar
AU  - Anđelković, Katarina K.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5154
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5155
AB  - In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.
PB  - Beograd : Srpsko hemijsko društvo
T1  - Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5155
ER  - 

@misc{
author = "Stevanović, Nevena and Jevtović, Mima and Mitić, Dragana and Matić, Ivana Z. and Crnogorac, Marija Đ. and Vujčić, Miroslava and Sladić, Dušan and Čobeljić, Božidar and Anđelković, Katarina K.",
year = "2022",
abstract = "In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.",
publisher = "Beograd : Srpsko hemijsko društvo",
title = "Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5155"
}

Stevanović, N., Jevtović, M., Mitić, D., Matić, I. Z., Crnogorac, M. Đ., Vujčić, M., Sladić, D., Čobeljić, B.,& Anđelković, K. K.. (2022). Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.. 
Beograd : Srpsko hemijsko društvo..
https://hdl.handle.net/21.15107/rcub_cherry_5155

Stevanović N, Jevtović M, Mitić D, Matić IZ, Crnogorac MĐ, Vujčić M, Sladić D, Čobeljić B, Anđelković KK. Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_5155 .

Stevanović, Nevena, Jevtović, Mima, Mitić, Dragana, Matić, Ivana Z., Crnogorac, Marija Đ., Vujčić, Miroslava, Sladić, Dušan, Čobeljić, Božidar, Anđelković, Katarina K., "Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S." (2022),
https://hdl.handle.net/21.15107/rcub_cherry_5155 .

TY  - JOUR
AU  - Marković, Olivera S.
AU  - Patel, Nirali G.
AU  - Serajuddin, Abu T. M.
AU  - Avdeef, Alex
AU  - Verbić, Tatjana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5039
AB  - The solubility of a model basic drug, nortriptyline
(Nor), was investigated as a function of pH in phosphate and/or a
chloride-containing aqueous suspension using experimental
practices recommended in the previously published “white
paper” (Avdeef et al., 2016). The pH-Ramp Shake-Flask (pHRSF) method, introduced in our earlier work (Marković et al.,
2019), was applied. An improved and more detailed experimental
design of the Nor solubility measurement allowed us to exploit the
full capacity of the pH-RSF method. Complex equilibria in the
aqueous phase (cationic and anionic complex formation between
Nor and the phosphate) and solid-phase transformations (Nor free
base, 1:1 Nor hydrochloride salt, 1:1 and 1:2 Nor phosphate salts)
were characterized by a detailed analysis of the solubility
measurements using the computer program pDISOL-X. The solid phases were characterized by thermogravimetric analysis,
differential scanning calorimetry, powder X-ray diffraction, and elemental analyses. The results of the present investigation illustrate
the influence of competing counterions, such as buffering agents, complexing agents, salt coformers, tonicity adjusters, and so forth,
on the aqueous solubility of drugs and interconversion of salts. Careful attention given to these factors can be helpful in the
formulation of drug products.
PB  - American Chemical Society
T2  - Molecular pharmaceutics
T1  - Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule “Soft” Constraints
VL  - 19
IS  - 2
SP  - 710
EP  - 719
DO  - 10.1021/acs.molpharmaceut.1c00919
ER  - 

@article{
author = "Marković, Olivera S. and Patel, Nirali G. and Serajuddin, Abu T. M. and Avdeef, Alex and Verbić, Tatjana",
year = "2022",
abstract = "The solubility of a model basic drug, nortriptyline
(Nor), was investigated as a function of pH in phosphate and/or a
chloride-containing aqueous suspension using experimental
practices recommended in the previously published “white
paper” (Avdeef et al., 2016). The pH-Ramp Shake-Flask (pHRSF) method, introduced in our earlier work (Marković et al.,
2019), was applied. An improved and more detailed experimental
design of the Nor solubility measurement allowed us to exploit the
full capacity of the pH-RSF method. Complex equilibria in the
aqueous phase (cationic and anionic complex formation between
Nor and the phosphate) and solid-phase transformations (Nor free
base, 1:1 Nor hydrochloride salt, 1:1 and 1:2 Nor phosphate salts)
were characterized by a detailed analysis of the solubility
measurements using the computer program pDISOL-X. The solid phases were characterized by thermogravimetric analysis,
differential scanning calorimetry, powder X-ray diffraction, and elemental analyses. The results of the present investigation illustrate
the influence of competing counterions, such as buffering agents, complexing agents, salt coformers, tonicity adjusters, and so forth,
on the aqueous solubility of drugs and interconversion of salts. Careful attention given to these factors can be helpful in the
formulation of drug products.",
publisher = "American Chemical Society",
journal = "Molecular pharmaceutics",
title = "Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule “Soft” Constraints",
volume = "19",
number = "2",
pages = "710-719",
doi = "10.1021/acs.molpharmaceut.1c00919"
}

Marković, O. S., Patel, N. G., Serajuddin, A. T. M., Avdeef, A.,& Verbić, T.. (2022). Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule “Soft” Constraints. in Molecular pharmaceutics
American Chemical Society., 19(2), 710-719.
https://doi.org/10.1021/acs.molpharmaceut.1c00919

Marković OS, Patel NG, Serajuddin ATM, Avdeef A, Verbić T. Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule “Soft” Constraints. in Molecular pharmaceutics. 2022;19(2):710-719.
doi:10.1021/acs.molpharmaceut.1c00919 .

Marković, Olivera S., Patel, Nirali G., Serajuddin, Abu T. M., Avdeef, Alex, Verbić, Tatjana, "Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule “Soft” Constraints" in Molecular pharmaceutics, 19, no. 2 (2022):710-719,
https://doi.org/10.1021/acs.molpharmaceut.1c00919 . .

TY  - JOUR
AU  - Stevanović, Gordana
AU  - Jović-Jovičić, Nataša
AU  - Krstić, Jugoslav
AU  - Milutinović-Nikolić, Aleksandra D.
AU  - Banković, Predrag
AU  - Popović, Aleksandar R.
AU  - Ajduković, Marija
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5662
AB  - Chitosan (Ch)-derived from biowaste along with smectite, an abundant clay mineral, were used in a low-cost and eco-friendly synthesis of a new type of catalyst. Nanocomposite catalysts constituted of Co supported on smectite with chitosan-derived carbon loading were obtained using an impregnation‑carbonization procedure and denoted as Co/cCh-S-T (T stands for applied carbonization temperature). The carbonization was performed in the temperature range from 400 °C to 700 °C in the flow of N2 providing inert atmosphere. The temperature of 500 °C was found to be the most suitable for catalyst synthesis regarding catalytic performance in a peroxymonosulfate activated degradation of tartrazine. The incorporation of carbonized chitosan structure within the interlamellar space of the smectite was confirmed using X-ray powder diffraction. The high-resolution transmission electron microscopy confirmed a layered structure of nanocomposites characteristic for smectite, as well as the presence of small spherical cobalt containing nanoformations (confirmed by energy dispersive X-ray spectroscopy) well dispersed within structure. The existance of cobalt in the CoII and CoIII oxidation state was proven by X-ray photoelectron spectroscopy. The Co/cCh-S-500 catalyst was proven to be stable and efficient after 5 consecutive cycles. This work showed that nanocomposite Co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators exhibited a very promising performance in the degradation of water pollutants.
PB  - Elsevier
T2  - Applied Clay Science
T1  - Nanocomposite co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators in degradation of tartrazine
VL  - 230
SP  - 106718
DO  - 10.1016/j.clay.2022.106718
ER  - 

@article{
author = "Stevanović, Gordana and Jović-Jovičić, Nataša and Krstić, Jugoslav and Milutinović-Nikolić, Aleksandra D. and Banković, Predrag and Popović, Aleksandar R. and Ajduković, Marija",
year = "2022",
abstract = "Chitosan (Ch)-derived from biowaste along with smectite, an abundant clay mineral, were used in a low-cost and eco-friendly synthesis of a new type of catalyst. Nanocomposite catalysts constituted of Co supported on smectite with chitosan-derived carbon loading were obtained using an impregnation‑carbonization procedure and denoted as Co/cCh-S-T (T stands for applied carbonization temperature). The carbonization was performed in the temperature range from 400 °C to 700 °C in the flow of N2 providing inert atmosphere. The temperature of 500 °C was found to be the most suitable for catalyst synthesis regarding catalytic performance in a peroxymonosulfate activated degradation of tartrazine. The incorporation of carbonized chitosan structure within the interlamellar space of the smectite was confirmed using X-ray powder diffraction. The high-resolution transmission electron microscopy confirmed a layered structure of nanocomposites characteristic for smectite, as well as the presence of small spherical cobalt containing nanoformations (confirmed by energy dispersive X-ray spectroscopy) well dispersed within structure. The existance of cobalt in the CoII and CoIII oxidation state was proven by X-ray photoelectron spectroscopy. The Co/cCh-S-500 catalyst was proven to be stable and efficient after 5 consecutive cycles. This work showed that nanocomposite Co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators exhibited a very promising performance in the degradation of water pollutants.",
publisher = "Elsevier",
journal = "Applied Clay Science",
title = "Nanocomposite co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators in degradation of tartrazine",
volume = "230",
pages = "106718",
doi = "10.1016/j.clay.2022.106718"
}

Stevanović, G., Jović-Jovičić, N., Krstić, J., Milutinović-Nikolić, A. D., Banković, P., Popović, A. R.,& Ajduković, M.. (2022). Nanocomposite co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators in degradation of tartrazine. in Applied Clay Science
Elsevier., 230, 106718.
https://doi.org/10.1016/j.clay.2022.106718

Stevanović G, Jović-Jovičić N, Krstić J, Milutinović-Nikolić AD, Banković P, Popović AR, Ajduković M. Nanocomposite co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators in degradation of tartrazine. in Applied Clay Science. 2022;230:106718.
doi:10.1016/j.clay.2022.106718 .

Stevanović, Gordana, Jović-Jovičić, Nataša, Krstić, Jugoslav, Milutinović-Nikolić, Aleksandra D., Banković, Predrag, Popović, Aleksandar R., Ajduković, Marija, "Nanocomposite co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators in degradation of tartrazine" in Applied Clay Science, 230 (2022):106718,
https://doi.org/10.1016/j.clay.2022.106718 . .

TY  - DATA
AU  - Stevanović, Gordana
AU  - Jović-Jovičić, Nataša
AU  - Krstić, Jugoslav
AU  - Milutinović-Nikolić, Aleksandra D.
AU  - Banković, Predrag
AU  - Popović, Aleksandar R.
AU  - Ajduković, Marija
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5671
AB  - Chitosan (Ch)-derived from biowaste along with smectite, an abundant clay mineral, were used in a low-cost and eco-friendly synthesis of a new type of catalyst. Nanocomposite catalysts constituted of Co supported on smectite with chitosan-derived carbon loading were obtained using an impregnation‑carbonization procedure and denoted as Co/cCh-S-T (T stands for applied carbonization temperature). The carbonization was performed in the temperature range from 400 °C to 700 °C in the flow of N2 providing inert atmosphere. The temperature of 500 °C was found to be the most suitable for catalyst synthesis regarding catalytic performance in a peroxymonosulfate activated degradation of tartrazine. The incorporation of carbonized chitosan structure within the interlamellar space of the smectite was confirmed using X-ray powder diffraction. The high-resolution transmission electron microscopy confirmed a layered structure of nanocomposites characteristic for smectite, as well as the presence of small spherical cobalt containing nanoformations (confirmed by energy dispersive X-ray spectroscopy) well dispersed within structure. The existance of cobalt in the CoII and CoIII oxidation state was proven by X-ray photoelectron spectroscopy. The Co/cCh-S-500 catalyst was proven to be stable and efficient after 5 consecutive cycles. This work showed that nanocomposite Co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators exhibited a very promising performance in the degradation of water pollutants.
PB  - Elsevier
T2  - Applied Clay Science
T1  - Supplementary material for: Stevanović, G., Jović-Jovičić, N., Krstić, J., Milutinović-Nikolić, A., Banković, P., Popović, A.,& Ajduković, M.. (2022). Nanocomposite co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators in degradation of tartrazine. in Applied Clay Science Elsevier., 230, 106718. https://doi.org/10.1016/j.clay.2022.106718
VL  - 230
SP  - 106718
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5671
ER  - 

@misc{
author = "Stevanović, Gordana and Jović-Jovičić, Nataša and Krstić, Jugoslav and Milutinović-Nikolić, Aleksandra D. and Banković, Predrag and Popović, Aleksandar R. and Ajduković, Marija",
year = "2022",
abstract = "Chitosan (Ch)-derived from biowaste along with smectite, an abundant clay mineral, were used in a low-cost and eco-friendly synthesis of a new type of catalyst. Nanocomposite catalysts constituted of Co supported on smectite with chitosan-derived carbon loading were obtained using an impregnation‑carbonization procedure and denoted as Co/cCh-S-T (T stands for applied carbonization temperature). The carbonization was performed in the temperature range from 400 °C to 700 °C in the flow of N2 providing inert atmosphere. The temperature of 500 °C was found to be the most suitable for catalyst synthesis regarding catalytic performance in a peroxymonosulfate activated degradation of tartrazine. The incorporation of carbonized chitosan structure within the interlamellar space of the smectite was confirmed using X-ray powder diffraction. The high-resolution transmission electron microscopy confirmed a layered structure of nanocomposites characteristic for smectite, as well as the presence of small spherical cobalt containing nanoformations (confirmed by energy dispersive X-ray spectroscopy) well dispersed within structure. The existance of cobalt in the CoII and CoIII oxidation state was proven by X-ray photoelectron spectroscopy. The Co/cCh-S-500 catalyst was proven to be stable and efficient after 5 consecutive cycles. This work showed that nanocomposite Co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators exhibited a very promising performance in the degradation of water pollutants.",
publisher = "Elsevier",
journal = "Applied Clay Science",
title = "Supplementary material for: Stevanović, G., Jović-Jovičić, N., Krstić, J., Milutinović-Nikolić, A., Banković, P., Popović, A.,& Ajduković, M.. (2022). Nanocomposite co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators in degradation of tartrazine. in Applied Clay Science Elsevier., 230, 106718. https://doi.org/10.1016/j.clay.2022.106718",
volume = "230",
pages = "106718",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5671"
}

Stevanović, G., Jović-Jovičić, N., Krstić, J., Milutinović-Nikolić, A. D., Banković, P., Popović, A. R.,& Ajduković, M.. (2022). Supplementary material for: Stevanović, G., Jović-Jovičić, N., Krstić, J., Milutinović-Nikolić, A., Banković, P., Popović, A.,& Ajduković, M.. (2022). Nanocomposite co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators in degradation of tartrazine. in Applied Clay Science Elsevier., 230, 106718. https://doi.org/10.1016/j.clay.2022.106718. in Applied Clay Science
Elsevier., 230, 106718.
https://hdl.handle.net/21.15107/rcub_cherry_5671

Stevanović G, Jović-Jovičić N, Krstić J, Milutinović-Nikolić AD, Banković P, Popović AR, Ajduković M. Supplementary material for: Stevanović, G., Jović-Jovičić, N., Krstić, J., Milutinović-Nikolić, A., Banković, P., Popović, A.,& Ajduković, M.. (2022). Nanocomposite co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators in degradation of tartrazine. in Applied Clay Science Elsevier., 230, 106718. https://doi.org/10.1016/j.clay.2022.106718. in Applied Clay Science. 2022;230:106718.
https://hdl.handle.net/21.15107/rcub_cherry_5671 .

Stevanović, Gordana, Jović-Jovičić, Nataša, Krstić, Jugoslav, Milutinović-Nikolić, Aleksandra D., Banković, Predrag, Popović, Aleksandar R., Ajduković, Marija, "Supplementary material for: Stevanović, G., Jović-Jovičić, N., Krstić, J., Milutinović-Nikolić, A., Banković, P., Popović, A.,& Ajduković, M.. (2022). Nanocomposite co-catalysts, based on smectite and biowaste-derived carbon, as peroxymonosulfate activators in degradation of tartrazine. in Applied Clay Science Elsevier., 230, 106718. https://doi.org/10.1016/j.clay.2022.106718" in Applied Clay Science, 230 (2022):106718,
https://hdl.handle.net/21.15107/rcub_cherry_5671 .