Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200288 (Innovation Center of the Faculty of Chemistry)

Link to this page

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Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200288 (Innovation Center of the Faculty of Chemistry) (en)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 451-03-68/2020-14/200288 (Inovacioni centar Hemijskog fakulteta u Beogradu doo) (sr_RS)
Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 451-03-68/2020-14/200288 (Иновациони центар Хемијског факултета у Београду доо) (sr)
Authors

Publications

Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems

Fotirić-Akšić, Milica M.; Dabić-Zagorac, Dragana; Gašić, Uroš M.; Tosti, Tomislav; Natić, Maja; Meland, Mekjell

(MDPI, 2022)

TY  - JOUR
AU  - Fotirić-Akšić, Milica M.
AU  - Dabić-Zagorac, Dragana
AU  - Gašić, Uroš M.
AU  - Tosti, Tomislav
AU  - Natić, Maja
AU  - Meland, Mekjell
PY  - 2022
UR  - https://www.mdpi.com/2071-1050/14/9/5300
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5178
AB  - The aim of this study was to compare total phenolic content (TPC), radical-scavenging activity (RSA), total anthocyanin content (TAC), sugar and polyphenolic profiles of two apple cultivars (‘Discovery’ and ‘Red Aroma Orelind’) from organic and integrated production systems in climatic conditions of Western Norway. Sixteen sugars and four sugar alcohols and 19 polyphenols were found in the peel, but less polyphenols were detected in the pulp. The peel of both apples and in both production systems had significantly higher TPC and RSA than the pulp. The peel from integrated apples had higher TPC than the peel from organic apples, while organic apples had higher TAC than the integrated. Sucrose and glucose levels were higher in organic apples; fructose was cultivar dependent while minor sugars were higher in integrated fruits. The most abundant polyphenolic compound in the peel of the tested cultivars was quercetin 3-O-galactoside, while chlorogenic acid was most abundant in the pulp. Regarding polyphenols, phloretin, phloridzin, protocatechuic acid, baicalein and naringenin were higher in organic apple, while quercetin 3-O-galactoside, kaempferol 3-O-glucoside, chlorogenic acid and syringic acid was higher in integrated fruits. In conclusion, organic ‘Discovery’ and integrated ‘Red Aroma Orelind’ had higher bioavailability of health related compounds from the peel and the pulp.
PB  - MDPI
T2  - Sustainability
T2  - Sustainability
T1  - Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems
VL  - 14
IS  - 9
SP  - 5300
DO  - 10.3390/su14095300
ER  - 
@article{
author = "Fotirić-Akšić, Milica M. and Dabić-Zagorac, Dragana and Gašić, Uroš M. and Tosti, Tomislav and Natić, Maja and Meland, Mekjell",
year = "2022",
abstract = "The aim of this study was to compare total phenolic content (TPC), radical-scavenging activity (RSA), total anthocyanin content (TAC), sugar and polyphenolic profiles of two apple cultivars (‘Discovery’ and ‘Red Aroma Orelind’) from organic and integrated production systems in climatic conditions of Western Norway. Sixteen sugars and four sugar alcohols and 19 polyphenols were found in the peel, but less polyphenols were detected in the pulp. The peel of both apples and in both production systems had significantly higher TPC and RSA than the pulp. The peel from integrated apples had higher TPC than the peel from organic apples, while organic apples had higher TAC than the integrated. Sucrose and glucose levels were higher in organic apples; fructose was cultivar dependent while minor sugars were higher in integrated fruits. The most abundant polyphenolic compound in the peel of the tested cultivars was quercetin 3-O-galactoside, while chlorogenic acid was most abundant in the pulp. Regarding polyphenols, phloretin, phloridzin, protocatechuic acid, baicalein and naringenin were higher in organic apple, while quercetin 3-O-galactoside, kaempferol 3-O-glucoside, chlorogenic acid and syringic acid was higher in integrated fruits. In conclusion, organic ‘Discovery’ and integrated ‘Red Aroma Orelind’ had higher bioavailability of health related compounds from the peel and the pulp.",
publisher = "MDPI",
journal = "Sustainability, Sustainability",
title = "Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems",
volume = "14",
number = "9",
pages = "5300",
doi = "10.3390/su14095300"
}
Fotirić-Akšić, M. M., Dabić-Zagorac, D., Gašić, U. M., Tosti, T., Natić, M.,& Meland, M.. (2022). Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems. in Sustainability
MDPI., 14(9), 5300.
https://doi.org/10.3390/su14095300
Fotirić-Akšić MM, Dabić-Zagorac D, Gašić UM, Tosti T, Natić M, Meland M. Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems. in Sustainability. 2022;14(9):5300.
doi:10.3390/su14095300 .
Fotirić-Akšić, Milica M., Dabić-Zagorac, Dragana, Gašić, Uroš M., Tosti, Tomislav, Natić, Maja, Meland, Mekjell, "Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems" in Sustainability, 14, no. 9 (2022):5300,
https://doi.org/10.3390/su14095300 . .
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2
2

Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer

Filipović, Lidija; Spasojević, Milica; Prodanović, Radivoje; Korać, Aleksandra; Matijaševic, Suzana; Brajušković, Goran; de Marco, Ario; Popović, Milica

(Elsevier, 2022)

TY  - JOUR
AU  - Filipović, Lidija
AU  - Spasojević, Milica
AU  - Prodanović, Radivoje
AU  - Korać, Aleksandra
AU  - Matijaševic, Suzana
AU  - Brajušković, Goran
AU  - de Marco, Ario
AU  - Popović, Milica
PY  - 2022
UR  - https://pubmed.ncbi.nlm.nih.gov/35301156/
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5152
AB  - Correct elucidation of physiological and pathological processes mediated by extracellular vesicles (EV) is highly dependent on the reliability of the method used for their purification. Currently available chemical/physical protocols for sample fractionation are time-consuming, often scarcely reproducible and their yields are low. Immuno-capture based approaches could represent an effective purification alternative to obtain homogeneous EV samples. An easy-to-operate chromatography system was set-up for the purification of intact EVs based on a single domain (VHH) antibodies-copolymer matrix suitable for biological samples as different as conditioned cell culture medium and human plasma. Methacrylate-based copolymer is a porous solid support, the chemical versatility of which enables its efficient functionalization with VHHs. The combined analyses of morphological features and biomarker (CD9, CD63 and CD81) presence indicated that the recovered EVs were exosomes. The lipoprotein markers APO-A1 and APO-B were both negative in tested samples. This is the first report demonstrating the successful application of spherical porous methacrylate-based copolymer coupled with VHHs for the exosome isolation from biological fluids. This inexpensive immunoaffinity method has the potential to be applied for the isolation of EVs belonging to different morphological and physiological classes.
PB  - Elsevier
T2  - New Biotechnology
T1  - Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer
VL  - 69
SP  - 36
EP  - 48
DO  - 10.1016/j.nbt.2022.03.001
ER  - 
@article{
author = "Filipović, Lidija and Spasojević, Milica and Prodanović, Radivoje and Korać, Aleksandra and Matijaševic, Suzana and Brajušković, Goran and de Marco, Ario and Popović, Milica",
year = "2022",
abstract = "Correct elucidation of physiological and pathological processes mediated by extracellular vesicles (EV) is highly dependent on the reliability of the method used for their purification. Currently available chemical/physical protocols for sample fractionation are time-consuming, often scarcely reproducible and their yields are low. Immuno-capture based approaches could represent an effective purification alternative to obtain homogeneous EV samples. An easy-to-operate chromatography system was set-up for the purification of intact EVs based on a single domain (VHH) antibodies-copolymer matrix suitable for biological samples as different as conditioned cell culture medium and human plasma. Methacrylate-based copolymer is a porous solid support, the chemical versatility of which enables its efficient functionalization with VHHs. The combined analyses of morphological features and biomarker (CD9, CD63 and CD81) presence indicated that the recovered EVs were exosomes. The lipoprotein markers APO-A1 and APO-B were both negative in tested samples. This is the first report demonstrating the successful application of spherical porous methacrylate-based copolymer coupled with VHHs for the exosome isolation from biological fluids. This inexpensive immunoaffinity method has the potential to be applied for the isolation of EVs belonging to different morphological and physiological classes.",
publisher = "Elsevier",
journal = "New Biotechnology",
title = "Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer",
volume = "69",
pages = "36-48",
doi = "10.1016/j.nbt.2022.03.001"
}
Filipović, L., Spasojević, M., Prodanović, R., Korać, A., Matijaševic, S., Brajušković, G., de Marco, A.,& Popović, M.. (2022). Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer. in New Biotechnology
Elsevier., 69, 36-48.
https://doi.org/10.1016/j.nbt.2022.03.001
Filipović L, Spasojević M, Prodanović R, Korać A, Matijaševic S, Brajušković G, de Marco A, Popović M. Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer. in New Biotechnology. 2022;69:36-48.
doi:10.1016/j.nbt.2022.03.001 .
Filipović, Lidija, Spasojević, Milica, Prodanović, Radivoje, Korać, Aleksandra, Matijaševic, Suzana, Brajušković, Goran, de Marco, Ario, Popović, Milica, "Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer" in New Biotechnology, 69 (2022):36-48,
https://doi.org/10.1016/j.nbt.2022.03.001 . .
1
1

Investigating possibilities for synthesis of novel sorbents and catalyst carriers based on ceramics with controlled open porosity: Original scientific paper

Nikolić, Vesna; Đokić, Jovana; Kamberović, Željko; Marinković, Aleksandar; Jevtić, Sanja; Anđić, Zoran

(2022)

TY  - JOUR
AU  - Nikolić, Vesna
AU  - Đokić, Jovana
AU  - Kamberović, Željko
AU  - Marinković, Aleksandar
AU  - Jevtić, Sanja
AU  - Anđić, Zoran
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5286
AB  - The aim of this study was to investigate a possibility of synthesis of porous ceramics with controlled open porosity, which could be used as sorbents and catalyst supports. Two organic additives were used to obtain open porosity: polystyrene beads and cellulose fibers, which are mixed with kaolin clay powder and the appropriate water content. Samples were sintered at 1050 oC for 1 h. Characterization of the obtained products included X-ray powder diffraction analysis (XRPD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and elemental CHNS analysis. In addition, porosity was examined by quantification of visual information. The specific surface areas were determined by the Brunauer–Emmett–Teller (BET) method. Also, density and compressive strength of the obtained samples were assessed. It was determined that by sintering, the organic component completely leaves the system. For samples prepared with polystyrene beads and with cellulose fibers, satisfactory mechanical properties were obtained: compressive strengths were 1.42 and 1.56 MPa, respectively. It was noted that significantly higher open porosity was obtained by using polystyrene beads as a sacrificial template (porosity of ~56 %) instead of cellulose fibers (porosity of ~6 %).
T2  - Hemijska industrija
T1  - Investigating possibilities for synthesis of novel sorbents and catalyst carriers based on ceramics with controlled open porosity: Original scientific paper
VL  - 76
DO  - 10.2298/HEMIND210809005N
ER  - 
@article{
author = "Nikolić, Vesna and Đokić, Jovana and Kamberović, Željko and Marinković, Aleksandar and Jevtić, Sanja and Anđić, Zoran",
year = "2022",
abstract = "The aim of this study was to investigate a possibility of synthesis of porous ceramics with controlled open porosity, which could be used as sorbents and catalyst supports. Two organic additives were used to obtain open porosity: polystyrene beads and cellulose fibers, which are mixed with kaolin clay powder and the appropriate water content. Samples were sintered at 1050 oC for 1 h. Characterization of the obtained products included X-ray powder diffraction analysis (XRPD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and elemental CHNS analysis. In addition, porosity was examined by quantification of visual information. The specific surface areas were determined by the Brunauer–Emmett–Teller (BET) method. Also, density and compressive strength of the obtained samples were assessed. It was determined that by sintering, the organic component completely leaves the system. For samples prepared with polystyrene beads and with cellulose fibers, satisfactory mechanical properties were obtained: compressive strengths were 1.42 and 1.56 MPa, respectively. It was noted that significantly higher open porosity was obtained by using polystyrene beads as a sacrificial template (porosity of ~56 %) instead of cellulose fibers (porosity of ~6 %).",
journal = "Hemijska industrija",
title = "Investigating possibilities for synthesis of novel sorbents and catalyst carriers based on ceramics with controlled open porosity: Original scientific paper",
volume = "76",
doi = "10.2298/HEMIND210809005N"
}
Nikolić, V., Đokić, J., Kamberović, Ž., Marinković, A., Jevtić, S.,& Anđić, Z.. (2022). Investigating possibilities for synthesis of novel sorbents and catalyst carriers based on ceramics with controlled open porosity: Original scientific paper. in Hemijska industrija, 76.
https://doi.org/10.2298/HEMIND210809005N
Nikolić V, Đokić J, Kamberović Ž, Marinković A, Jevtić S, Anđić Z. Investigating possibilities for synthesis of novel sorbents and catalyst carriers based on ceramics with controlled open porosity: Original scientific paper. in Hemijska industrija. 2022;76.
doi:10.2298/HEMIND210809005N .
Nikolić, Vesna, Đokić, Jovana, Kamberović, Željko, Marinković, Aleksandar, Jevtić, Sanja, Anđić, Zoran, "Investigating possibilities for synthesis of novel sorbents and catalyst carriers based on ceramics with controlled open porosity: Original scientific paper" in Hemijska industrija, 76 (2022),
https://doi.org/10.2298/HEMIND210809005N . .

Immobilization of Horseradish Peroxidase on Macroporous Glycidyl-Based Copolymers with Different Surface Characteristics for the Removal of Phenol

Pantić, Nevena; Spasojević, Milica; Stojanović, Željko; Veljović, Đorđe; Krstić, Jugoslav; Balaž, Ana Marija; Prodanović, Radivoje; Prodanović, Olivera

(Springer, 2022)

TY  - JOUR
AU  - Pantić, Nevena
AU  - Spasojević, Milica
AU  - Stojanović, Željko
AU  - Veljović, Đorđe
AU  - Krstić, Jugoslav
AU  - Balaž, Ana Marija
AU  - Prodanović, Radivoje
AU  - Prodanović, Olivera
PY  - 2022
UR  - https://link.springer.com/article/10.1007/s10924-021-02364-3
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5205
AB  - Novel macroporous copolymers of glycidyl methacrylate and ethylene glycol dimethacrylate with mean pore size diameters ranging from 150 to 310 nm were synthesized by dispersion polymerization and modified with ethylenediamine. The glutaraldehyde and periodate method were employed to immobilize horseradish peroxidase (HRP) onto these carriers. The activity of the immobilized enzyme was greatly affected by the pore size of the carrier. The highest specific activities of 9.65 and 8.94 U/g of dry weight were obtained for HRP immobilized by the periodate-route onto poly(GMA‐co‐EGDMA) carriers with pore size diameters of 234 and 297 nm, respectively. Stability studies showed an improved operational stability of immobilized peroxidase at 65 °C and in an organic solvent. HRP immobilized on a copolymer with a pore size of 234 nm, showing the highest specific activity and good stability, had higher activities at almost all pH values than the native enzyme and the increased Km value for pyrogallol oxidation. Immobilized HRP retained 80% of its original activity after five consecutive cycles of the pyrogallol oxidation and 98% of its initial activity in a storage stability study. Enzyme immobilized onto the macroporous copolymer with the pore size diameter of 234 nm showed a substantial degree of phenol removal achieved by immobilized peroxidase.
PB  - Springer
T2  - Journal of Polymers and the Environment
T1  - Immobilization of Horseradish Peroxidase on Macroporous Glycidyl-Based Copolymers with Different Surface Characteristics for the Removal of Phenol
DO  - 10.1007/s10924-021-02364-3
ER  - 
@article{
author = "Pantić, Nevena and Spasojević, Milica and Stojanović, Željko and Veljović, Đorđe and Krstić, Jugoslav and Balaž, Ana Marija and Prodanović, Radivoje and Prodanović, Olivera",
year = "2022",
abstract = "Novel macroporous copolymers of glycidyl methacrylate and ethylene glycol dimethacrylate with mean pore size diameters ranging from 150 to 310 nm were synthesized by dispersion polymerization and modified with ethylenediamine. The glutaraldehyde and periodate method were employed to immobilize horseradish peroxidase (HRP) onto these carriers. The activity of the immobilized enzyme was greatly affected by the pore size of the carrier. The highest specific activities of 9.65 and 8.94 U/g of dry weight were obtained for HRP immobilized by the periodate-route onto poly(GMA‐co‐EGDMA) carriers with pore size diameters of 234 and 297 nm, respectively. Stability studies showed an improved operational stability of immobilized peroxidase at 65 °C and in an organic solvent. HRP immobilized on a copolymer with a pore size of 234 nm, showing the highest specific activity and good stability, had higher activities at almost all pH values than the native enzyme and the increased Km value for pyrogallol oxidation. Immobilized HRP retained 80% of its original activity after five consecutive cycles of the pyrogallol oxidation and 98% of its initial activity in a storage stability study. Enzyme immobilized onto the macroporous copolymer with the pore size diameter of 234 nm showed a substantial degree of phenol removal achieved by immobilized peroxidase.",
publisher = "Springer",
journal = "Journal of Polymers and the Environment",
title = "Immobilization of Horseradish Peroxidase on Macroporous Glycidyl-Based Copolymers with Different Surface Characteristics for the Removal of Phenol",
doi = "10.1007/s10924-021-02364-3"
}
Pantić, N., Spasojević, M., Stojanović, Ž., Veljović, Đ., Krstić, J., Balaž, A. M., Prodanović, R.,& Prodanović, O.. (2022). Immobilization of Horseradish Peroxidase on Macroporous Glycidyl-Based Copolymers with Different Surface Characteristics for the Removal of Phenol. in Journal of Polymers and the Environment
Springer..
https://doi.org/10.1007/s10924-021-02364-3
Pantić N, Spasojević M, Stojanović Ž, Veljović Đ, Krstić J, Balaž AM, Prodanović R, Prodanović O. Immobilization of Horseradish Peroxidase on Macroporous Glycidyl-Based Copolymers with Different Surface Characteristics for the Removal of Phenol. in Journal of Polymers and the Environment. 2022;.
doi:10.1007/s10924-021-02364-3 .
Pantić, Nevena, Spasojević, Milica, Stojanović, Željko, Veljović, Đorđe, Krstić, Jugoslav, Balaž, Ana Marija, Prodanović, Radivoje, Prodanović, Olivera, "Immobilization of Horseradish Peroxidase on Macroporous Glycidyl-Based Copolymers with Different Surface Characteristics for the Removal of Phenol" in Journal of Polymers and the Environment (2022),
https://doi.org/10.1007/s10924-021-02364-3 . .

Evaluation of antitumor potential of Cu(II) complex with hydrazone of 2-acetylthiazole and Girard’s T reagent

Stevanović, Nevena; Jevtović, Mima; Mitić, Dragana; Matić, Ivana Z.; Crnogorac, Marija Đ.; Vujčić, Miroslava; Sladić, Dušan; Čobeljić, Božidar; Anđelković, Katarina K.

(Beograd : Srpsko hemijsko društvo, 2022)

TY  - JOUR
AU  - Stevanović, Nevena
AU  - Jevtović, Mima
AU  - Mitić, Dragana
AU  - Matić, Ivana Z.
AU  - Crnogorac, Marija Đ.
AU  - Vujčić, Miroslava
AU  - Sladić, Dušan
AU  - Čobeljić, Božidar
AU  - Anđelković, Katarina K.
PY  - 2022
UR  - http://www.doiserbia.nb.rs/img/doi/0352-5139/2022/0352-51392202181S.pdf
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5154
AB  - In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.
PB  - Beograd : Srpsko hemijsko društvo
T1  - Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent
VL  - 87
IS  - 2
SP  - 181
EP  - 192
DO  - 10.2298/JSC211203114S
ER  - 
@article{
author = "Stevanović, Nevena and Jevtović, Mima and Mitić, Dragana and Matić, Ivana Z. and Crnogorac, Marija Đ. and Vujčić, Miroslava and Sladić, Dušan and Čobeljić, Božidar and Anđelković, Katarina K.",
year = "2022",
abstract = "In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.",
publisher = "Beograd : Srpsko hemijsko društvo",
title = "Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent",
volume = "87",
number = "2",
pages = "181-192",
doi = "10.2298/JSC211203114S"
}
Stevanović, N., Jevtović, M., Mitić, D., Matić, I. Z., Crnogorac, M. Đ., Vujčić, M., Sladić, D., Čobeljić, B.,& Anđelković, K. K.. (2022). Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent. 
Beograd : Srpsko hemijsko društvo., 87(2), 181-192.
https://doi.org/10.2298/JSC211203114S
Stevanović N, Jevtović M, Mitić D, Matić IZ, Crnogorac MĐ, Vujčić M, Sladić D, Čobeljić B, Anđelković KK. Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent. 2022;87(2):181-192.
doi:10.2298/JSC211203114S .
Stevanović, Nevena, Jevtović, Mima, Mitić, Dragana, Matić, Ivana Z., Crnogorac, Marija Đ., Vujčić, Miroslava, Sladić, Dušan, Čobeljić, Božidar, Anđelković, Katarina K., "Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent", 87, no. 2 (2022):181-192,
https://doi.org/10.2298/JSC211203114S . .

Co(III), Ni(II), and Cu(II) complexes with tetradentate Schiff base ligand: Synthesis, Characterization, Electrochemical Behavior, Binding assessment and In vitro cytotoxicity activity

Mirković, Marija D.; Radović, Magdalena; Stanković, Dalibor; Vranješ-Đurić, Sanja; Janković, Drina; Petrović, Djordje; Mihajlović-Lalić, Ljiljana E.; Prijović, Željko; Milanović, Zorana

(Taylor & Francis Ltd, 2022)

TY  - JOUR
AU  - Mirković, Marija D.
AU  - Radović, Magdalena
AU  - Stanković, Dalibor
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
AU  - Petrović, Djordje
AU  - Mihajlović-Lalić, Ljiljana E.
AU  - Prijović, Željko
AU  - Milanović, Zorana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5135
AB  - Two new Schiff base cobalt(III) ([Co(LH)Cl2], 1) and nickel(II) ([Ni(LH)ClO4], 2) complexes with a diimine-dioxime ligand, (4,9-diaza-3,10-diethyl-3,9-dodecadiene-2,11-dione bis oxime (LH2)), were synthesized and characterized. The compounds were obtained in MeOH from corresponding metal salts and LH2 in molar ratio 1:1 and further characterized by mass spectrometry, IR spectroscopy, electrochemistry, and elemental analysis. Previously reported copper(II) analog, ([Cu2(LH)2]·(ClO4)2, 3) was joined to 1 and 2, and the three metal analogs, 1-3, were further investigated in terms of their electrochemical behavior. The binding studies of the complexes with deoxyribonucleic acid (DNA) and human serum albumin (HSA) were carried out using both spectrophotometric and electrochemical methods. All three complexes exhibit binding affinity towards the DNA chain through intercalative interaction. The binding reaction with HSA showed for 1 and 3 complexes decrease in the peak current obtained in the case of complexes before the addition of HSA, while resulted compound obtained from Ni complex – HSA possesses the same electroactivity as starting complex. Furthermore, the cytotoxicity of LH2 as well as its metal complexes, and cisplatin were evaluated on CT-26 mouse colon carcinoma and human LS174T cancer cell lines employing MTT assay. The copper(II) complex exhibited very promising anticancer activity compared with cisplatin.
PB  - Taylor & Francis Ltd
T2  - Journal of Coordination Chemistry
T1  - Co(III), Ni(II), and Cu(II) complexes with tetradentate Schiff base ligand: Synthesis, Characterization, Electrochemical Behavior, Binding assessment and In vitro cytotoxicity activity
DO  - 10.1080/00958972.2022.2032683
ER  - 
@article{
author = "Mirković, Marija D. and Radović, Magdalena and Stanković, Dalibor and Vranješ-Đurić, Sanja and Janković, Drina and Petrović, Djordje and Mihajlović-Lalić, Ljiljana E. and Prijović, Željko and Milanović, Zorana",
year = "2022",
abstract = "Two new Schiff base cobalt(III) ([Co(LH)Cl2], 1) and nickel(II) ([Ni(LH)ClO4], 2) complexes with a diimine-dioxime ligand, (4,9-diaza-3,10-diethyl-3,9-dodecadiene-2,11-dione bis oxime (LH2)), were synthesized and characterized. The compounds were obtained in MeOH from corresponding metal salts and LH2 in molar ratio 1:1 and further characterized by mass spectrometry, IR spectroscopy, electrochemistry, and elemental analysis. Previously reported copper(II) analog, ([Cu2(LH)2]·(ClO4)2, 3) was joined to 1 and 2, and the three metal analogs, 1-3, were further investigated in terms of their electrochemical behavior. The binding studies of the complexes with deoxyribonucleic acid (DNA) and human serum albumin (HSA) were carried out using both spectrophotometric and electrochemical methods. All three complexes exhibit binding affinity towards the DNA chain through intercalative interaction. The binding reaction with HSA showed for 1 and 3 complexes decrease in the peak current obtained in the case of complexes before the addition of HSA, while resulted compound obtained from Ni complex – HSA possesses the same electroactivity as starting complex. Furthermore, the cytotoxicity of LH2 as well as its metal complexes, and cisplatin were evaluated on CT-26 mouse colon carcinoma and human LS174T cancer cell lines employing MTT assay. The copper(II) complex exhibited very promising anticancer activity compared with cisplatin.",
publisher = "Taylor & Francis Ltd",
journal = "Journal of Coordination Chemistry",
title = "Co(III), Ni(II), and Cu(II) complexes with tetradentate Schiff base ligand: Synthesis, Characterization, Electrochemical Behavior, Binding assessment and In vitro cytotoxicity activity",
doi = "10.1080/00958972.2022.2032683"
}
Mirković, M. D., Radović, M., Stanković, D., Vranješ-Đurić, S., Janković, D., Petrović, D., Mihajlović-Lalić, L. E., Prijović, Ž.,& Milanović, Z.. (2022). Co(III), Ni(II), and Cu(II) complexes with tetradentate Schiff base ligand: Synthesis, Characterization, Electrochemical Behavior, Binding assessment and In vitro cytotoxicity activity. in Journal of Coordination Chemistry
Taylor & Francis Ltd..
https://doi.org/10.1080/00958972.2022.2032683
Mirković MD, Radović M, Stanković D, Vranješ-Đurić S, Janković D, Petrović D, Mihajlović-Lalić LE, Prijović Ž, Milanović Z. Co(III), Ni(II), and Cu(II) complexes with tetradentate Schiff base ligand: Synthesis, Characterization, Electrochemical Behavior, Binding assessment and In vitro cytotoxicity activity. in Journal of Coordination Chemistry. 2022;.
doi:10.1080/00958972.2022.2032683 .
Mirković, Marija D., Radović, Magdalena, Stanković, Dalibor, Vranješ-Đurić, Sanja, Janković, Drina, Petrović, Djordje, Mihajlović-Lalić, Ljiljana E., Prijović, Željko, Milanović, Zorana, "Co(III), Ni(II), and Cu(II) complexes with tetradentate Schiff base ligand: Synthesis, Characterization, Electrochemical Behavior, Binding assessment and In vitro cytotoxicity activity" in Journal of Coordination Chemistry (2022),
https://doi.org/10.1080/00958972.2022.2032683 . .
1
1

The low-temperature sonochemical synthesis of up-converting β NaYF4: Yb,Er mesocrystals

Vuković, Marina; Dinic, Ivana; Jardim, Paola; Marković, Smilja; Veselinović, Ljiljana M.; Nikolić, Marko G.; Mancic, Lidija

(Elsevier, 2022)

TY  - JOUR
AU  - Vuković, Marina
AU  - Dinic, Ivana
AU  - Jardim, Paola
AU  - Marković, Smilja
AU  - Veselinović, Ljiljana M.
AU  - Nikolić, Marko G.
AU  - Mancic, Lidija
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4894
AB  - In this paper, we report the mild sonochemical synthesis of hexagonal (β) NaYF4:Yb,Er mesocrystals at
low temperature of 40 °C. The nucleation and transformation of crystal structures is investigated in
the course of time, and it is shown that the pure β phase is obtained after 2 h of pulsed sonication.
The crystallization of orthorhombic YF3:Yb,Er and cubic (α) NaYF4:Yb,Er precedes the appearance of a
thermodynamically stable β NaYF4:Yb,Er phase. Based on the evolution of the nanoparticle morphology,
it is concluded that the transition from a to β phase is consistent with the dissolution-recrystallization
process, while the final shape of mesocrystals is a consequence of the oriented attachment growth in
the newly formed b phase nanocrystallites along two planes. The structural properties of all compounds
are analyzed and correlated with their thermal and optical characteristics. The pump power dependence
of green and red emissions confirms that only two-photon process is involved in up-conversion, which is
superior in β phase mesocrystals.
PB  - Elsevier
T2  - Advanced Powder Technology
T1  - The low-temperature sonochemical synthesis of up-converting β NaYF4: Yb,Er mesocrystals
VL  - 33
IS  - 2
SP  - 103403
DO  - 10.1016/j.apt.2021.103403
ER  - 
@article{
author = "Vuković, Marina and Dinic, Ivana and Jardim, Paola and Marković, Smilja and Veselinović, Ljiljana M. and Nikolić, Marko G. and Mancic, Lidija",
year = "2022",
abstract = "In this paper, we report the mild sonochemical synthesis of hexagonal (β) NaYF4:Yb,Er mesocrystals at
low temperature of 40 °C. The nucleation and transformation of crystal structures is investigated in
the course of time, and it is shown that the pure β phase is obtained after 2 h of pulsed sonication.
The crystallization of orthorhombic YF3:Yb,Er and cubic (α) NaYF4:Yb,Er precedes the appearance of a
thermodynamically stable β NaYF4:Yb,Er phase. Based on the evolution of the nanoparticle morphology,
it is concluded that the transition from a to β phase is consistent with the dissolution-recrystallization
process, while the final shape of mesocrystals is a consequence of the oriented attachment growth in
the newly formed b phase nanocrystallites along two planes. The structural properties of all compounds
are analyzed and correlated with their thermal and optical characteristics. The pump power dependence
of green and red emissions confirms that only two-photon process is involved in up-conversion, which is
superior in β phase mesocrystals.",
publisher = "Elsevier",
journal = "Advanced Powder Technology",
title = "The low-temperature sonochemical synthesis of up-converting β NaYF4: Yb,Er mesocrystals",
volume = "33",
number = "2",
pages = "103403",
doi = "10.1016/j.apt.2021.103403"
}
Vuković, M., Dinic, I., Jardim, P., Marković, S., Veselinović, L. M., Nikolić, M. G.,& Mancic, L.. (2022). The low-temperature sonochemical synthesis of up-converting β NaYF4: Yb,Er mesocrystals. in Advanced Powder Technology
Elsevier., 33(2), 103403.
https://doi.org/10.1016/j.apt.2021.103403
Vuković M, Dinic I, Jardim P, Marković S, Veselinović LM, Nikolić MG, Mancic L. The low-temperature sonochemical synthesis of up-converting β NaYF4: Yb,Er mesocrystals. in Advanced Powder Technology. 2022;33(2):103403.
doi:10.1016/j.apt.2021.103403 .
Vuković, Marina, Dinic, Ivana, Jardim, Paola, Marković, Smilja, Veselinović, Ljiljana M., Nikolić, Marko G., Mancic, Lidija, "The low-temperature sonochemical synthesis of up-converting β NaYF4: Yb,Er mesocrystals" in Advanced Powder Technology, 33, no. 2 (2022):103403,
https://doi.org/10.1016/j.apt.2021.103403 . .

The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals

Vuković, Marina; Dinić, Ivana; Jardim, Paula; Marković, Smilja; Veselinović, Ljiljana M.; Nikolić, Marko G.; Mančić, Lidija

(Elsevier BV, 2022)

TY  - JOUR
AU  - Vuković, Marina
AU  - Dinić, Ivana
AU  - Jardim, Paula
AU  - Marković, Smilja
AU  - Veselinović, Ljiljana M.
AU  - Nikolić, Marko G.
AU  - Mančić, Lidija
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5119
AB  - In this paper, we report the mild sonochemical synthesis of hexagonal (β) NaYF4:Yb,Er mesocrystals at low temperature of 40 °C. The nucleation and transformation of crystal structures is investigated in the course of time, and it is shown that the pure β phase is obtained after 2 h of pulsed sonication. The crystallization of orthorhombic YF3:Yb,Er and cubic (α) NaYF4:Yb,Er precedes the appearance of a thermodynamically stable β NaYF4:Yb,Er phase. Based on the evolution of the nanoparticle morphology, it is concluded that the transition from α to β phase is consistent with the dissolution-recrystallization process, while the final shape of mesocrystals is a consequence of the oriented attachment growth in the newly formed β phase nanocrystallites along two planes. The structural properties of all compounds are analyzed and correlated with their thermal and optical characteristics. The pump power dependence of green and red emissions confirms that only two-photon process is involved in up-conversion, which is superior in β phase mesocrystals.
PB  - Elsevier BV
T2  - Advanced Powder Technology
T1  - The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals
VL  - 33
IS  - 2
SP  - 103403
DO  - 10.1016/j.apt.2021.103403
ER  - 
@article{
author = "Vuković, Marina and Dinić, Ivana and Jardim, Paula and Marković, Smilja and Veselinović, Ljiljana M. and Nikolić, Marko G. and Mančić, Lidija",
year = "2022",
abstract = "In this paper, we report the mild sonochemical synthesis of hexagonal (β) NaYF4:Yb,Er mesocrystals at low temperature of 40 °C. The nucleation and transformation of crystal structures is investigated in the course of time, and it is shown that the pure β phase is obtained after 2 h of pulsed sonication. The crystallization of orthorhombic YF3:Yb,Er and cubic (α) NaYF4:Yb,Er precedes the appearance of a thermodynamically stable β NaYF4:Yb,Er phase. Based on the evolution of the nanoparticle morphology, it is concluded that the transition from α to β phase is consistent with the dissolution-recrystallization process, while the final shape of mesocrystals is a consequence of the oriented attachment growth in the newly formed β phase nanocrystallites along two planes. The structural properties of all compounds are analyzed and correlated with their thermal and optical characteristics. The pump power dependence of green and red emissions confirms that only two-photon process is involved in up-conversion, which is superior in β phase mesocrystals.",
publisher = "Elsevier BV",
journal = "Advanced Powder Technology",
title = "The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals",
volume = "33",
number = "2",
pages = "103403",
doi = "10.1016/j.apt.2021.103403"
}
Vuković, M., Dinić, I., Jardim, P., Marković, S., Veselinović, L. M., Nikolić, M. G.,& Mančić, L.. (2022). The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals. in Advanced Powder Technology
Elsevier BV., 33(2), 103403.
https://doi.org/10.1016/j.apt.2021.103403
Vuković M, Dinić I, Jardim P, Marković S, Veselinović LM, Nikolić MG, Mančić L. The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals. in Advanced Powder Technology. 2022;33(2):103403.
doi:10.1016/j.apt.2021.103403 .
Vuković, Marina, Dinić, Ivana, Jardim, Paula, Marković, Smilja, Veselinović, Ljiljana M., Nikolić, Marko G., Mančić, Lidija, "The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals" in Advanced Powder Technology, 33, no. 2 (2022):103403,
https://doi.org/10.1016/j.apt.2021.103403 . .

Supplementary information for the article: Vuković, Marina, Dinić, Ivana, Jardim, Paula, Marković, Smilja, Veselinović, Ljiljana, Nikolić, Marko, Mančić, Lidija, "The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals" in Advanced Powder Technology, 33, no. 2 (2022):103403, https://doi.org/10.1016/j.apt.2021.103403

Vuković, Marina; Dinić, Ivana; Jardim, Paula; Marković, Smilja; Veselinović, Ljiljana M.; Nikolić, Marko G.; Mančić, Lidija

(Elsevier BV, 2022)

TY  - DATA
AU  - Vuković, Marina
AU  - Dinić, Ivana
AU  - Jardim, Paula
AU  - Marković, Smilja
AU  - Veselinović, Ljiljana M.
AU  - Nikolić, Marko G.
AU  - Mančić, Lidija
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5120
AB  - Figure S1. XRPD data and refined patterns of the obtained samples; Figure S2. Typical spectrum of FT-IR analysis; Figure S3. XRPD of samples obtained through sonochemical synthesis after DSC analysis; Figure S4: Simulated electron diffraction pattern of β NaYF4:Yb,Er hexagonal [-111] zone axis  compared with experimental SAED; Figure S5: Simulated electron diffraction pattern of β NaYF4:Yb,Er hexagonal [2-10] zone axis  compared with experimental SAED
PB  - Elsevier BV
T2  - Advanced Powder Technology
T1  - Supplementary information for the article: Vuković, Marina, Dinić, Ivana, Jardim, Paula, Marković, Smilja, Veselinović, Ljiljana, Nikolić, Marko, Mančić, Lidija, "The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals" in Advanced Powder Technology, 33, no. 2 (2022):103403, https://doi.org/10.1016/j.apt.2021.103403
VL  - 33
IS  - 2
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5120
ER  - 
@misc{
author = "Vuković, Marina and Dinić, Ivana and Jardim, Paula and Marković, Smilja and Veselinović, Ljiljana M. and Nikolić, Marko G. and Mančić, Lidija",
year = "2022",
abstract = "Figure S1. XRPD data and refined patterns of the obtained samples; Figure S2. Typical spectrum of FT-IR analysis; Figure S3. XRPD of samples obtained through sonochemical synthesis after DSC analysis; Figure S4: Simulated electron diffraction pattern of β NaYF4:Yb,Er hexagonal [-111] zone axis  compared with experimental SAED; Figure S5: Simulated electron diffraction pattern of β NaYF4:Yb,Er hexagonal [2-10] zone axis  compared with experimental SAED",
publisher = "Elsevier BV",
journal = "Advanced Powder Technology",
title = "Supplementary information for the article: Vuković, Marina, Dinić, Ivana, Jardim, Paula, Marković, Smilja, Veselinović, Ljiljana, Nikolić, Marko, Mančić, Lidija, "The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals" in Advanced Powder Technology, 33, no. 2 (2022):103403, https://doi.org/10.1016/j.apt.2021.103403",
volume = "33",
number = "2",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5120"
}
Vuković, M., Dinić, I., Jardim, P., Marković, S., Veselinović, L. M., Nikolić, M. G.,& Mančić, L.. (2022). Supplementary information for the article: Vuković, Marina, Dinić, Ivana, Jardim, Paula, Marković, Smilja, Veselinović, Ljiljana, Nikolić, Marko, Mančić, Lidija, "The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals" in Advanced Powder Technology, 33, no. 2 (2022):103403, https://doi.org/10.1016/j.apt.2021.103403. in Advanced Powder Technology
Elsevier BV., 33(2).
https://hdl.handle.net/21.15107/rcub_cherry_5120
Vuković M, Dinić I, Jardim P, Marković S, Veselinović LM, Nikolić MG, Mančić L. Supplementary information for the article: Vuković, Marina, Dinić, Ivana, Jardim, Paula, Marković, Smilja, Veselinović, Ljiljana, Nikolić, Marko, Mančić, Lidija, "The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals" in Advanced Powder Technology, 33, no. 2 (2022):103403, https://doi.org/10.1016/j.apt.2021.103403. in Advanced Powder Technology. 2022;33(2).
https://hdl.handle.net/21.15107/rcub_cherry_5120 .
Vuković, Marina, Dinić, Ivana, Jardim, Paula, Marković, Smilja, Veselinović, Ljiljana M., Nikolić, Marko G., Mančić, Lidija, "Supplementary information for the article: Vuković, Marina, Dinić, Ivana, Jardim, Paula, Marković, Smilja, Veselinović, Ljiljana, Nikolić, Marko, Mančić, Lidija, "The low-temperature sonochemical synthesis of up-converting β NaYF4:Yb,Er mesocrystals" in Advanced Powder Technology, 33, no. 2 (2022):103403, https://doi.org/10.1016/j.apt.2021.103403" in Advanced Powder Technology, 33, no. 2 (2022),
https://hdl.handle.net/21.15107/rcub_cherry_5120 .

Significance of infrared spectroscopic branching factor for investigation of structural characteristics of alkanes, geochemical properties and viscosity of oils: Scientific paper

Stevanović, Jelena Z.; Rakitin, Anton R.; Kojić, Ivan D.; Vuković, Nikola S.; Stojanović, Ksenija A.

(Belgrade : Serbian Chemical Society, 2022)

TY  - JOUR
AU  - Stevanović, Jelena Z.
AU  - Rakitin, Anton R.
AU  - Kojić, Ivan D.
AU  - Vuković, Nikola S.
AU  - Stojanović, Ksenija A.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4854
AB  - A detailed investigation of significance of the infrared (IR) spectro­scopic branching factor (СН2/СН3; the ratio of methylene and methyl group peak heights at 2917–2921 and 2951–2954 cm-1, respectively in the IR spectra) for charac­te­ri­za­tion of alkane structure, geochemical properties and viscosity of 76 oil samples was performed. These oils, originating from 13 Serbian oil fields in SE Pannonian Basin, differ according to source and depositional envi­ronment of organic matter (OM), as well as by thermal maturity and biodeg­rad­ation stage. Methylene and methyl asymmetric stretching peak absorbances were used for the branching factor calculation. CH2 peak positions exhibited3–4 cm-1 red shift with increasing the CH2/CH3 ratio, due to a greater contri­bution of trans vs. gauche rotamers in ali­pha­tic chains. Comparing IR spectra of the oils and model n-alkanes, it was established that the average (CH2)n methylene chain length per СН3 group varied from n = 3.5 to 6.5. The CH2/CH3 ratio showed significant concordance with geochemical para­meters, enabling clear distinction of the oils according to source and deposi­ti­onal environment of OM. At the same time, dependence of the CH2/CH3 ratio on oil maturity in the range from immature to mature was not observed, allowing for an accurate determination of oil genetic types irrespective of maturity. The CH2/CH3 ratio showed good accordance with oil biodegradation scale and oil viscosity.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Significance of infrared spectroscopic branching factor for investigation of structural characteristics of alkanes, geochemical properties and viscosity of oils: Scientific paper
VL  - 87
IS  - 1
SP  - 41
EP  - 55
DO  - 10.2298/JSC210830091S
ER  - 
@article{
author = "Stevanović, Jelena Z. and Rakitin, Anton R. and Kojić, Ivan D. and Vuković, Nikola S. and Stojanović, Ksenija A.",
year = "2022",
abstract = "A detailed investigation of significance of the infrared (IR) spectro­scopic branching factor (СН2/СН3; the ratio of methylene and methyl group peak heights at 2917–2921 and 2951–2954 cm-1, respectively in the IR spectra) for charac­te­ri­za­tion of alkane structure, geochemical properties and viscosity of 76 oil samples was performed. These oils, originating from 13 Serbian oil fields in SE Pannonian Basin, differ according to source and depositional envi­ronment of organic matter (OM), as well as by thermal maturity and biodeg­rad­ation stage. Methylene and methyl asymmetric stretching peak absorbances were used for the branching factor calculation. CH2 peak positions exhibited3–4 cm-1 red shift with increasing the CH2/CH3 ratio, due to a greater contri­bution of trans vs. gauche rotamers in ali­pha­tic chains. Comparing IR spectra of the oils and model n-alkanes, it was established that the average (CH2)n methylene chain length per СН3 group varied from n = 3.5 to 6.5. The CH2/CH3 ratio showed significant concordance with geochemical para­meters, enabling clear distinction of the oils according to source and deposi­ti­onal environment of OM. At the same time, dependence of the CH2/CH3 ratio on oil maturity in the range from immature to mature was not observed, allowing for an accurate determination of oil genetic types irrespective of maturity. The CH2/CH3 ratio showed good accordance with oil biodegradation scale and oil viscosity.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Significance of infrared spectroscopic branching factor for investigation of structural characteristics of alkanes, geochemical properties and viscosity of oils: Scientific paper",
volume = "87",
number = "1",
pages = "41-55",
doi = "10.2298/JSC210830091S"
}
Stevanović, J. Z., Rakitin, A. R., Kojić, I. D., Vuković, N. S.,& Stojanović, K. A.. (2022). Significance of infrared spectroscopic branching factor for investigation of structural characteristics of alkanes, geochemical properties and viscosity of oils: Scientific paper. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 87(1), 41-55.
https://doi.org/10.2298/JSC210830091S
Stevanović JZ, Rakitin AR, Kojić ID, Vuković NS, Stojanović KA. Significance of infrared spectroscopic branching factor for investigation of structural characteristics of alkanes, geochemical properties and viscosity of oils: Scientific paper. in Journal of the Serbian Chemical Society. 2022;87(1):41-55.
doi:10.2298/JSC210830091S .
Stevanović, Jelena Z., Rakitin, Anton R., Kojić, Ivan D., Vuković, Nikola S., Stojanović, Ksenija A., "Significance of infrared spectroscopic branching factor for investigation of structural characteristics of alkanes, geochemical properties and viscosity of oils: Scientific paper" in Journal of the Serbian Chemical Society, 87, no. 1 (2022):41-55,
https://doi.org/10.2298/JSC210830091S . .

Supplementary data for the article: Stevanović, J. Z.; Rakitin, A. R.; Kojić, I. D.; Vuković, N. S.; Stojanović, K. Significance of Infrared Spectroscopic Branching Factor for Investigation of Structural Characteristics of Alkanes, Geochemical Properties and Viscosity of Oils: Scientific Paper. Journal of the Serbian Chemical Society 2022, 87 (1), 41–55. https://doi.org/10.2298/JSC210830091S.

Stevanović, Jelena Z.; Rakitin, Anton R.; Kojić, Ivan D.; Vuković, Nikola S.; Stojanović, Ksenija A.

(Belgrade : Serbian Chemical Society, 2022)

TY  - DATA
AU  - Stevanović, Jelena Z.
AU  - Rakitin, Anton R.
AU  - Kojić, Ivan D.
AU  - Vuković, Nikola S.
AU  - Stojanović, Ksenija A.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4855
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Supplementary data for the article: Stevanović, J. Z.; Rakitin, A. R.; Kojić, I. D.; Vuković, N. S.; Stojanović, K. Significance of Infrared Spectroscopic Branching Factor for Investigation of Structural Characteristics of Alkanes, Geochemical Properties and Viscosity of Oils: Scientific Paper. Journal of the Serbian Chemical Society 2022, 87 (1), 41–55. https://doi.org/10.2298/JSC210830091S.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4855
ER  - 
@misc{
author = "Stevanović, Jelena Z. and Rakitin, Anton R. and Kojić, Ivan D. and Vuković, Nikola S. and Stojanović, Ksenija A.",
year = "2022",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Supplementary data for the article: Stevanović, J. Z.; Rakitin, A. R.; Kojić, I. D.; Vuković, N. S.; Stojanović, K. Significance of Infrared Spectroscopic Branching Factor for Investigation of Structural Characteristics of Alkanes, Geochemical Properties and Viscosity of Oils: Scientific Paper. Journal of the Serbian Chemical Society 2022, 87 (1), 41–55. https://doi.org/10.2298/JSC210830091S.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4855"
}
Stevanović, J. Z., Rakitin, A. R., Kojić, I. D., Vuković, N. S.,& Stojanović, K. A.. (2022). Supplementary data for the article: Stevanović, J. Z.; Rakitin, A. R.; Kojić, I. D.; Vuković, N. S.; Stojanović, K. Significance of Infrared Spectroscopic Branching Factor for Investigation of Structural Characteristics of Alkanes, Geochemical Properties and Viscosity of Oils: Scientific Paper. Journal of the Serbian Chemical Society 2022, 87 (1), 41–55. https://doi.org/10.2298/JSC210830091S.. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society..
https://hdl.handle.net/21.15107/rcub_cherry_4855
Stevanović JZ, Rakitin AR, Kojić ID, Vuković NS, Stojanović KA. Supplementary data for the article: Stevanović, J. Z.; Rakitin, A. R.; Kojić, I. D.; Vuković, N. S.; Stojanović, K. Significance of Infrared Spectroscopic Branching Factor for Investigation of Structural Characteristics of Alkanes, Geochemical Properties and Viscosity of Oils: Scientific Paper. Journal of the Serbian Chemical Society 2022, 87 (1), 41–55. https://doi.org/10.2298/JSC210830091S.. in Journal of the Serbian Chemical Society. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_4855 .
Stevanović, Jelena Z., Rakitin, Anton R., Kojić, Ivan D., Vuković, Nikola S., Stojanović, Ksenija A., "Supplementary data for the article: Stevanović, J. Z.; Rakitin, A. R.; Kojić, I. D.; Vuković, N. S.; Stojanović, K. Significance of Infrared Spectroscopic Branching Factor for Investigation of Structural Characteristics of Alkanes, Geochemical Properties and Viscosity of Oils: Scientific Paper. Journal of the Serbian Chemical Society 2022, 87 (1), 41–55. https://doi.org/10.2298/JSC210830091S." in Journal of the Serbian Chemical Society (2022),
https://hdl.handle.net/21.15107/rcub_cherry_4855 .

Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.

Stevanović, Nevena; Jevtović, Mima; Mitić, Dragana; Matić, Ivana Z.; Crnogorac, Marija Đ.; Vujčić, Miroslava; Sladić, Dušan; Čobeljić, Božidar; Anđelković, Katarina K.

(Beograd : Srpsko hemijsko društvo, 2022)

TY  - DATA
AU  - Stevanović, Nevena
AU  - Jevtović, Mima
AU  - Mitić, Dragana
AU  - Matić, Ivana Z.
AU  - Crnogorac, Marija Đ.
AU  - Vujčić, Miroslava
AU  - Sladić, Dušan
AU  - Čobeljić, Božidar
AU  - Anđelković, Katarina K.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5154
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5155
AB  - In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.
PB  - Beograd : Srpsko hemijsko društvo
T1  - Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5155
ER  - 
@misc{
author = "Stevanović, Nevena and Jevtović, Mima and Mitić, Dragana and Matić, Ivana Z. and Crnogorac, Marija Đ. and Vujčić, Miroslava and Sladić, Dušan and Čobeljić, Božidar and Anđelković, Katarina K.",
year = "2022",
abstract = "In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.",
publisher = "Beograd : Srpsko hemijsko društvo",
title = "Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5155"
}
Stevanović, N., Jevtović, M., Mitić, D., Matić, I. Z., Crnogorac, M. Đ., Vujčić, M., Sladić, D., Čobeljić, B.,& Anđelković, K. K.. (2022). Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.. 
Beograd : Srpsko hemijsko društvo..
https://hdl.handle.net/21.15107/rcub_cherry_5155
Stevanović N, Jevtović M, Mitić D, Matić IZ, Crnogorac MĐ, Vujčić M, Sladić D, Čobeljić B, Anđelković KK. Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_5155 .
Stevanović, Nevena, Jevtović, Mima, Mitić, Dragana, Matić, Ivana Z., Crnogorac, Marija Đ., Vujčić, Miroslava, Sladić, Dušan, Čobeljić, Božidar, Anđelković, Katarina K., "Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S." (2022),
https://hdl.handle.net/21.15107/rcub_cherry_5155 .

Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products

Selaković, Života; Nikolić, Andrea; Ajdačić, Vladimir; Opsenica, Igor

(Wiley, 2022)

TY  - JOUR
AU  - Selaković, Života
AU  - Nikolić, Andrea
AU  - Ajdačić, Vladimir
AU  - Opsenica, Igor
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4871
AB  - Decarbonylation is an invaluable reaction, utilized by nature and chemists alike. In different life forms, such as prokaryotes, plants and animals, this transformation is catalyzed by aldehyde decarbonylases. In the laboratory, the transition metal-catalyzed (TMC) decarbonylation, which was first achieved in 1959, is by and large the dominant way for conducting this reaction. The carbon-carbon bond cleavage is most often made possible by RhCl(PPh3)3 i. e. Wilkinson's catalyst, but other metals are also used, both in academia and in industry. In this review, we chose to present the applications of TMC decarbonylation in the synthesis of natural products and their derivatives. More than 30 examples are showcased and categorized into three categories based on the essence of the role of the aldehyde group in the synthesis. A short outlook is given in the end, listing the different advantages and disadvantages of Wilkinson's catalyst, as well as offering a brief prospect for the future.
PB  - Wiley
T2  - European Journal of Organic Chemistry
T1  - Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products
VL  - 2022
IS  - 1
SP  - e202101265
DO  - 10.1002/ejoc.202101265
ER  - 
@article{
author = "Selaković, Života and Nikolić, Andrea and Ajdačić, Vladimir and Opsenica, Igor",
year = "2022",
abstract = "Decarbonylation is an invaluable reaction, utilized by nature and chemists alike. In different life forms, such as prokaryotes, plants and animals, this transformation is catalyzed by aldehyde decarbonylases. In the laboratory, the transition metal-catalyzed (TMC) decarbonylation, which was first achieved in 1959, is by and large the dominant way for conducting this reaction. The carbon-carbon bond cleavage is most often made possible by RhCl(PPh3)3 i. e. Wilkinson's catalyst, but other metals are also used, both in academia and in industry. In this review, we chose to present the applications of TMC decarbonylation in the synthesis of natural products and their derivatives. More than 30 examples are showcased and categorized into three categories based on the essence of the role of the aldehyde group in the synthesis. A short outlook is given in the end, listing the different advantages and disadvantages of Wilkinson's catalyst, as well as offering a brief prospect for the future.",
publisher = "Wiley",
journal = "European Journal of Organic Chemistry",
title = "Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products",
volume = "2022",
number = "1",
pages = "e202101265",
doi = "10.1002/ejoc.202101265"
}
Selaković, Ž., Nikolić, A., Ajdačić, V.,& Opsenica, I.. (2022). Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products. in European Journal of Organic Chemistry
Wiley., 2022(1), e202101265.
https://doi.org/10.1002/ejoc.202101265
Selaković Ž, Nikolić A, Ajdačić V, Opsenica I. Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products. in European Journal of Organic Chemistry. 2022;2022(1):e202101265.
doi:10.1002/ejoc.202101265 .
Selaković, Života, Nikolić, Andrea, Ajdačić, Vladimir, Opsenica, Igor, "Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products" in European Journal of Organic Chemistry, 2022, no. 1 (2022):e202101265,
https://doi.org/10.1002/ejoc.202101265 . .
5
1
1

Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?

FIlipović, Lidija; Kojadinović, Milica I.; Popović, Milica M.

(Elsevier, 2022)

TY  - JOUR
AU  - FIlipović, Lidija
AU  - Kojadinović, Milica I.
AU  - Popović, Milica M.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4989
AB  - Exosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will also be discussed in this review.
PB  - Elsevier
T2  - Journal of Drug Delivery Science and Technology
T1  - Exosomes and exosome-mimetics as targeted drug carriers: Where we stand  and what the future holds?
VL  - 68
SP  - 103057
DO  - 10.1016/j.jddst.2021.103057
ER  - 
@article{
author = "FIlipović, Lidija and Kojadinović, Milica I. and Popović, Milica M.",
year = "2022",
abstract = "Exosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will also be discussed in this review.",
publisher = "Elsevier",
journal = "Journal of Drug Delivery Science and Technology",
title = "Exosomes and exosome-mimetics as targeted drug carriers: Where we stand  and what the future holds?",
volume = "68",
pages = "103057",
doi = "10.1016/j.jddst.2021.103057"
}
FIlipović, L., Kojadinović, M. I.,& Popović, M. M.. (2022). Exosomes and exosome-mimetics as targeted drug carriers: Where we stand  and what the future holds?. in Journal of Drug Delivery Science and Technology
Elsevier., 68, 103057.
https://doi.org/10.1016/j.jddst.2021.103057
FIlipović L, Kojadinović MI, Popović MM. Exosomes and exosome-mimetics as targeted drug carriers: Where we stand  and what the future holds?. in Journal of Drug Delivery Science and Technology. 2022;68:103057.
doi:10.1016/j.jddst.2021.103057 .
FIlipović, Lidija, Kojadinović, Milica I., Popović, Milica M., "Exosomes and exosome-mimetics as targeted drug carriers: Where we stand  and what the future holds?" in Journal of Drug Delivery Science and Technology, 68 (2022):103057,
https://doi.org/10.1016/j.jddst.2021.103057 . .

Exosomes and exosome-mimetics as targeted drug carriers: Where we stand and what the future holds?

FIlipović, Lidija; Kojadinović, Milica I.; Popović, Milica M.

(Elsevier, 2022)

TY  - JOUR
AU  - FIlipović, Lidija
AU  - Kojadinović, Milica I.
AU  - Popović, Milica M.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4997
AB  - Exosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will also be discussed in this review.
PB  - Elsevier
T2  - Journal of Drug Delivery Science and Technology
T1  - Exosomes and exosome-mimetics as targeted drug carriers: Where we stand  and what the future holds?
VL  - 68
SP  - 103057
DO  - 10.1016/j.jddst.2021.103057
ER  - 
@article{
author = "FIlipović, Lidija and Kojadinović, Milica I. and Popović, Milica M.",
year = "2022",
abstract = "Exosomes are a sub-group of extracellular vesicles, playing an important part in a cell-cell communication in many physiological and pathological conditions. Their size and competence for transferring material to recipient cells make them a promising nanocarrier for clinical use. Their non-immunogenic nature, similar to the body's own structure make them far superior transporters compared to liposomes and polymeric nanoparticles. This review, will provide an overview of exosome biogenesis, biological role, and purification methods. The focus of this manuscript will be to summarize specific applications of exosomes and exosome-mimetics as drug delivery systems in pharmaceutical drug development. We will describe drug-loading approaches, in vivo and in vitro exosome tracing methods, specific modifications and examples of the delivery of therapeutic and imaging molecules from a variety of biological origins. Challenges in the translation of exosome-based drug carriers to clinical use will also be discussed in this review.",
publisher = "Elsevier",
journal = "Journal of Drug Delivery Science and Technology",
title = "Exosomes and exosome-mimetics as targeted drug carriers: Where we stand  and what the future holds?",
volume = "68",
pages = "103057",
doi = "10.1016/j.jddst.2021.103057"
}
FIlipović, L., Kojadinović, M. I.,& Popović, M. M.. (2022). Exosomes and exosome-mimetics as targeted drug carriers: Where we stand  and what the future holds?. in Journal of Drug Delivery Science and Technology
Elsevier., 68, 103057.
https://doi.org/10.1016/j.jddst.2021.103057
FIlipović L, Kojadinović MI, Popović MM. Exosomes and exosome-mimetics as targeted drug carriers: Where we stand  and what the future holds?. in Journal of Drug Delivery Science and Technology. 2022;68:103057.
doi:10.1016/j.jddst.2021.103057 .
FIlipović, Lidija, Kojadinović, Milica I., Popović, Milica M., "Exosomes and exosome-mimetics as targeted drug carriers: Where we stand  and what the future holds?" in Journal of Drug Delivery Science and Technology, 68 (2022):103057,
https://doi.org/10.1016/j.jddst.2021.103057 . .

Molecular recognition of acetylcholinesterase and its subnanomolar reversible inhibitor: a molecular simulations study

Vitorović-Todorović, Maja D.; Cvijetić, Ilija; Zloh, Mire; Perdih, Andrej

(Taylor & Francis, 2022)

TY  - JOUR
AU  - Vitorović-Todorović, Maja D.
AU  - Cvijetić, Ilija
AU  - Zloh, Mire
AU  - Perdih, Andrej
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4979
AB  - Recently, we designed and synthesized a subnanomolar, reversible, dual-binding site acetylcholinesterase (AChE) inhibitor which consists of the tacrine and aroylacrylic acid phenylamide moieties, mutually linked by eight methylene units. To further investigate the process of the molecular recognition between the AChE and its inhibitor, we performed six unconstrained molecular dynamics (MD) simulations, where the compound in three possible protonation states was placed inside binding sites of two available AChE crystal structures. In all six MD trajectories, the ligand generally occupied similar space inside the AChE active site, but the pattern of the interactions between the ligand functional groups and the amino acid residues was significantly different and highly dependent upon the crystal structure used to generate initial systems for simulation. The greatest differences were observed between the trajectories obtained with different AChE crystal structures used as starting target conformations. In some trajectories, several unusual positions and dynamic behavior of the tacrine moiety were observed. Therefore, this study provides important structure-based data useful in further optimization of the reversible, dual binding AChE inhibitors, and also emphasizes the importance of the starting crystal structure used for dynamics as well as the protonation state of the reversible inhibitors.Communicated by Ramaswamy H. Sarma
PB  - Taylor & Francis
T2  - Journal of Biomolecular Structure and Dynamics
T1  - Molecular recognition of acetylcholinesterase and its subnanomolar reversible inhibitor: a molecular simulations study
VL  - 40
IS  - 4
SP  - 1671
EP  - 1691
DO  - 10.1080/07391102.2020.1831960
ER  - 
@article{
author = "Vitorović-Todorović, Maja D. and Cvijetić, Ilija and Zloh, Mire and Perdih, Andrej",
year = "2022",
abstract = "Recently, we designed and synthesized a subnanomolar, reversible, dual-binding site acetylcholinesterase (AChE) inhibitor which consists of the tacrine and aroylacrylic acid phenylamide moieties, mutually linked by eight methylene units. To further investigate the process of the molecular recognition between the AChE and its inhibitor, we performed six unconstrained molecular dynamics (MD) simulations, where the compound in three possible protonation states was placed inside binding sites of two available AChE crystal structures. In all six MD trajectories, the ligand generally occupied similar space inside the AChE active site, but the pattern of the interactions between the ligand functional groups and the amino acid residues was significantly different and highly dependent upon the crystal structure used to generate initial systems for simulation. The greatest differences were observed between the trajectories obtained with different AChE crystal structures used as starting target conformations. In some trajectories, several unusual positions and dynamic behavior of the tacrine moiety were observed. Therefore, this study provides important structure-based data useful in further optimization of the reversible, dual binding AChE inhibitors, and also emphasizes the importance of the starting crystal structure used for dynamics as well as the protonation state of the reversible inhibitors.Communicated by Ramaswamy H. Sarma",
publisher = "Taylor & Francis",
journal = "Journal of Biomolecular Structure and Dynamics",
title = "Molecular recognition of acetylcholinesterase and its subnanomolar reversible inhibitor: a molecular simulations study",
volume = "40",
number = "4",
pages = "1671-1691",
doi = "10.1080/07391102.2020.1831960"
}
Vitorović-Todorović, M. D., Cvijetić, I., Zloh, M.,& Perdih, A.. (2022). Molecular recognition of acetylcholinesterase and its subnanomolar reversible inhibitor: a molecular simulations study. in Journal of Biomolecular Structure and Dynamics
Taylor & Francis., 40(4), 1671-1691.
https://doi.org/10.1080/07391102.2020.1831960
Vitorović-Todorović MD, Cvijetić I, Zloh M, Perdih A. Molecular recognition of acetylcholinesterase and its subnanomolar reversible inhibitor: a molecular simulations study. in Journal of Biomolecular Structure and Dynamics. 2022;40(4):1671-1691.
doi:10.1080/07391102.2020.1831960 .
Vitorović-Todorović, Maja D., Cvijetić, Ilija, Zloh, Mire, Perdih, Andrej, "Molecular recognition of acetylcholinesterase and its subnanomolar reversible inhibitor: a molecular simulations study" in Journal of Biomolecular Structure and Dynamics, 40, no. 4 (2022):1671-1691,
https://doi.org/10.1080/07391102.2020.1831960 . .
1
1
1

Supplementary data for the article: Vitorović-Todorović, M.; Cvijetić, I.; Zloh, M.; Perdih, A. Molecular Recognition of Acetylcholinesterase and Its Subnanomolar Reversible Inhibitor: A Molecular Simulations Study. Journal of Biomolecular Structure and Dynamics 2022, 40 (4), 1671–1691. https://doi.org/10.1080/07391102.2020.1831960.

Vitorović-Todorović, Maja D.; Cvijetić, Ilija; Zloh, Mire; Perdih, Andrej

(Taylor & Francis, 2022)

TY  - DATA
AU  - Vitorović-Todorović, Maja D.
AU  - Cvijetić, Ilija
AU  - Zloh, Mire
AU  - Perdih, Andrej
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4980
AB  - Recently, we designed and synthesized a subnanomolar, reversible, dual-binding site acetylcholinesterase (AChE) inhibitor which consists of the tacrine and aroylacrylic acid phenylamide moieties, mutually linked by eight methylene units. To further investigate the process of the molecular recognition between the AChE and its inhibitor, we performed six unconstrained molecular dynamics (MD) simulations, where the compound in three possible protonation states was placed inside binding sites of two available AChE crystal structures. In all six MD trajectories, the ligand generally occupied similar space inside the AChE active site, but the pattern of the interactions between the ligand functional groups and the amino acid residues was significantly different and highly dependent upon the crystal structure used to generate initial systems for simulation. The greatest differences were observed between the trajectories obtained with different AChE crystal structures used as starting target conformations. In some trajectories, several unusual positions and dynamic behavior of the tacrine moiety were observed. Therefore, this study provides important structure-based data useful in further optimization of the reversible, dual binding AChE inhibitors, and also emphasizes the importance of the starting crystal structure used for dynamics as well as the protonation state of the reversible inhibitors.
PB  - Taylor & Francis
T2  - Journal of Biomolecular Structure and Dynamics
T1  - Supplementary data for the article: Vitorović-Todorović, M.; Cvijetić, I.; Zloh, M.; Perdih, A. Molecular Recognition of Acetylcholinesterase and Its Subnanomolar Reversible Inhibitor: A Molecular Simulations Study. Journal of Biomolecular Structure and Dynamics 2022, 40 (4), 1671–1691. https://doi.org/10.1080/07391102.2020.1831960.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4980
ER  - 
@misc{
author = "Vitorović-Todorović, Maja D. and Cvijetić, Ilija and Zloh, Mire and Perdih, Andrej",
year = "2022",
abstract = "Recently, we designed and synthesized a subnanomolar, reversible, dual-binding site acetylcholinesterase (AChE) inhibitor which consists of the tacrine and aroylacrylic acid phenylamide moieties, mutually linked by eight methylene units. To further investigate the process of the molecular recognition between the AChE and its inhibitor, we performed six unconstrained molecular dynamics (MD) simulations, where the compound in three possible protonation states was placed inside binding sites of two available AChE crystal structures. In all six MD trajectories, the ligand generally occupied similar space inside the AChE active site, but the pattern of the interactions between the ligand functional groups and the amino acid residues was significantly different and highly dependent upon the crystal structure used to generate initial systems for simulation. The greatest differences were observed between the trajectories obtained with different AChE crystal structures used as starting target conformations. In some trajectories, several unusual positions and dynamic behavior of the tacrine moiety were observed. Therefore, this study provides important structure-based data useful in further optimization of the reversible, dual binding AChE inhibitors, and also emphasizes the importance of the starting crystal structure used for dynamics as well as the protonation state of the reversible inhibitors.",
publisher = "Taylor & Francis",
journal = "Journal of Biomolecular Structure and Dynamics",
title = "Supplementary data for the article: Vitorović-Todorović, M.; Cvijetić, I.; Zloh, M.; Perdih, A. Molecular Recognition of Acetylcholinesterase and Its Subnanomolar Reversible Inhibitor: A Molecular Simulations Study. Journal of Biomolecular Structure and Dynamics 2022, 40 (4), 1671–1691. https://doi.org/10.1080/07391102.2020.1831960.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4980"
}
Vitorović-Todorović, M. D., Cvijetić, I., Zloh, M.,& Perdih, A.. (2022). Supplementary data for the article: Vitorović-Todorović, M.; Cvijetić, I.; Zloh, M.; Perdih, A. Molecular Recognition of Acetylcholinesterase and Its Subnanomolar Reversible Inhibitor: A Molecular Simulations Study. Journal of Biomolecular Structure and Dynamics 2022, 40 (4), 1671–1691. https://doi.org/10.1080/07391102.2020.1831960.. in Journal of Biomolecular Structure and Dynamics
Taylor & Francis..
https://hdl.handle.net/21.15107/rcub_cherry_4980
Vitorović-Todorović MD, Cvijetić I, Zloh M, Perdih A. Supplementary data for the article: Vitorović-Todorović, M.; Cvijetić, I.; Zloh, M.; Perdih, A. Molecular Recognition of Acetylcholinesterase and Its Subnanomolar Reversible Inhibitor: A Molecular Simulations Study. Journal of Biomolecular Structure and Dynamics 2022, 40 (4), 1671–1691. https://doi.org/10.1080/07391102.2020.1831960.. in Journal of Biomolecular Structure and Dynamics. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_4980 .
Vitorović-Todorović, Maja D., Cvijetić, Ilija, Zloh, Mire, Perdih, Andrej, "Supplementary data for the article: Vitorović-Todorović, M.; Cvijetić, I.; Zloh, M.; Perdih, A. Molecular Recognition of Acetylcholinesterase and Its Subnanomolar Reversible Inhibitor: A Molecular Simulations Study. Journal of Biomolecular Structure and Dynamics 2022, 40 (4), 1671–1691. https://doi.org/10.1080/07391102.2020.1831960." in Journal of Biomolecular Structure and Dynamics (2022),
https://hdl.handle.net/21.15107/rcub_cherry_4980 .

Унапређивање хемијске писмености ученика основних школа кроз контекстуални приступ обради наставне јединице Алкани

Putica, Katarina; Ralević, Lidija

(Учитељски факултет Универзитета у Београду, 2022)

TY  - JOUR
AU  - Putica, Katarina
AU  - Ralević, Lidija 
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5022
AB  - Органска хемија представља есенцијални део свакодневног живота, али претходна истраживања указују да традиционална настава органске хемије, фокусирана на трансмисију академских знања, недовољно подстиче развој ученичке хемијске писмености у овој области. Будући да контекстуални приступ настави има потенцијал да унапреди научну писменост, ради поређења ефективности поменута два наставна приступа у погледу развоја хемијске писмености ученика основних школа у области органске хемије, спроведен је педагошки експеримент са паралелним групама. Експеримент је организован у оквиру обраде наставне јединице
Алкани и у њему је учествовало 148 ученика осмог разреда основне школе (76 ученика у експерименталној и 72 ученика у контролној групи). Кроз обраду градива о алканима ученици развијају хемијску писменост, која је у вези са структуром и номенклатуром ових једињења, њиховим физичким и хемијским својствима, те нафтом и нафтним дериватима као изворима енергије, али и загађивачима животне средине. Након обраде поменуте наставне јединице експериментална група је остварила статистички значајно већи укупан проценат тачних одговора на тесту, којим је проверена развијеност ученичке хемијске писмености о алканима на сва три њена нивоа (знање, примена и резоновање), што указује да би контекстуални приступ настави могао значајно да унапреди хемијску писменост ученика основних школа у области органске хемије.
AB  - Organic chemistry represents an essential part of everyday life, but previous research indicates
that traditional organic chemistry teaching, which focuses on the transmission of academic content, insufficiently promotes the development of pupils’ chemical literacy in this field. Since context-based teaching approach has the potential to improve scientific literacy, in order to compare the effectiveness of the aforementioned teaching approaches in terms of developing elementary school pupils’ chemical literacy in the field of organic chemistry, a pedagogical experiment with parallel groups was conducted. The experiment was organized within the elaboration of the teaching unit Alkanes and it encompassed 148 eighth-grade elementary school pupils (76 pupils in the experimental and 72 pupils in the control group). Through the elaboration of the content about alkanes, pupils develop chemical literacy in regard to the structure and nomenclature of these compounds, their physical and chemical properties and oil and its derivatives as energy sources, as well as environmental pollutants. Upon the elaboration of the abovementioned teaching unit, the experimental group achieved a significantly higher overall percentage of correct answers on the test that checked the development of pupils’ chemical literacy in regard to alkanes on all three levels (knowledge, application and reasoning), which implies that context-based teaching approach could significantly enhance elementary school pupils’ chemical literacy, in the field of organic chemistry.
PB  - Учитељски факултет Универзитета у Београду
T2  - Inovacije u nastavi
T1  - Унапређивање хемијске писмености ученика основних школа кроз контекстуални приступ обради наставне јединице Алкани
VL  - 35
IS  - 1
SP  - 91
EP  - 100
DO  - 10.5937/inovacije2201091P
ER  - 
@article{
author = "Putica, Katarina and Ralević, Lidija ",
year = "2022",
abstract = "Органска хемија представља есенцијални део свакодневног живота, али претходна истраживања указују да традиционална настава органске хемије, фокусирана на трансмисију академских знања, недовољно подстиче развој ученичке хемијске писмености у овој области. Будући да контекстуални приступ настави има потенцијал да унапреди научну писменост, ради поређења ефективности поменута два наставна приступа у погледу развоја хемијске писмености ученика основних школа у области органске хемије, спроведен је педагошки експеримент са паралелним групама. Експеримент је организован у оквиру обраде наставне јединице
Алкани и у њему је учествовало 148 ученика осмог разреда основне школе (76 ученика у експерименталној и 72 ученика у контролној групи). Кроз обраду градива о алканима ученици развијају хемијску писменост, која је у вези са структуром и номенклатуром ових једињења, њиховим физичким и хемијским својствима, те нафтом и нафтним дериватима као изворима енергије, али и загађивачима животне средине. Након обраде поменуте наставне јединице експериментална група је остварила статистички значајно већи укупан проценат тачних одговора на тесту, којим је проверена развијеност ученичке хемијске писмености о алканима на сва три њена нивоа (знање, примена и резоновање), што указује да би контекстуални приступ настави могао значајно да унапреди хемијску писменост ученика основних школа у области органске хемије., Organic chemistry represents an essential part of everyday life, but previous research indicates
that traditional organic chemistry teaching, which focuses on the transmission of academic content, insufficiently promotes the development of pupils’ chemical literacy in this field. Since context-based teaching approach has the potential to improve scientific literacy, in order to compare the effectiveness of the aforementioned teaching approaches in terms of developing elementary school pupils’ chemical literacy in the field of organic chemistry, a pedagogical experiment with parallel groups was conducted. The experiment was organized within the elaboration of the teaching unit Alkanes and it encompassed 148 eighth-grade elementary school pupils (76 pupils in the experimental and 72 pupils in the control group). Through the elaboration of the content about alkanes, pupils develop chemical literacy in regard to the structure and nomenclature of these compounds, their physical and chemical properties and oil and its derivatives as energy sources, as well as environmental pollutants. Upon the elaboration of the abovementioned teaching unit, the experimental group achieved a significantly higher overall percentage of correct answers on the test that checked the development of pupils’ chemical literacy in regard to alkanes on all three levels (knowledge, application and reasoning), which implies that context-based teaching approach could significantly enhance elementary school pupils’ chemical literacy, in the field of organic chemistry.",
publisher = "Учитељски факултет Универзитета у Београду",
journal = "Inovacije u nastavi",
title = "Унапређивање хемијске писмености ученика основних школа кроз контекстуални приступ обради наставне јединице Алкани",
volume = "35",
number = "1",
pages = "91-100",
doi = "10.5937/inovacije2201091P"
}
Putica, K.,& Ralević, L.. (2022). Унапређивање хемијске писмености ученика основних школа кроз контекстуални приступ обради наставне јединице Алкани. in Inovacije u nastavi
Учитељски факултет Универзитета у Београду., 35(1), 91-100.
https://doi.org/10.5937/inovacije2201091P
Putica K, Ralević L. Унапређивање хемијске писмености ученика основних школа кроз контекстуални приступ обради наставне јединице Алкани. in Inovacije u nastavi. 2022;35(1):91-100.
doi:10.5937/inovacije2201091P .
Putica, Katarina, Ralević, Lidija , "Унапређивање хемијске писмености ученика основних школа кроз контекстуални приступ обради наставне јединице Алкани" in Inovacije u nastavi, 35, no. 1 (2022):91-100,
https://doi.org/10.5937/inovacije2201091P . .

Drug combination study of novel oxorhenium(V) complexes

Petrović, Tamara; Gligorijević, Nevenka; Belaj, Ferdinand; Aranđelović, Sandra; Mihajlović-Lalić, Ljiljana E.; Grgurić-Šipka, Sanja; Poljarević, Jelena

(Elsevier, 2022)

TY  - JOUR
AU  - Petrović, Tamara
AU  - Gligorijević, Nevenka
AU  - Belaj, Ferdinand
AU  - Aranđelović, Sandra
AU  - Mihajlović-Lalić, Ljiljana E.
AU  - Grgurić-Šipka, Sanja
AU  - Poljarević, Jelena
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5046
AB  - Three Re(V) complexes of structural formulas [ReOCl2L(PPh3)], where L is pyridine-2-carboxylic acid (C1), 3-
methyl-pyridine-2-carboxylic acid (C2) and 6-methyl-pyridine-2-carboxylic acid (C3) were synthesized and
characterized using NMR, IR spectroscopy and mass spectrometry. Crystal structures of all three complexes have
been additionally confirmed by X-ray analysis. The biological activity has been investigated in the panel of tumor
cell lines A549, PANC-1, MDA-MB-231, MCF-7, LS-174, EAhy.926 and one in non-tumor cell line MRC-5. Only
C1 showed dose-dependent cytotoxic potential, particularly toward triple-negative breast adenocarcinoma cells
MDA-MB-231 with IC50 68.90 ± 1.73 μM and pancreatic adenocarcinoma cells PANC-1 with IC50 69.84 ± 2.3
μM. Both cell lines are characterized by a highly invasive and resistant phenotype. Drug combination studies in
PANC-1 cells with C1 and Verapamil hydrochloride (VRP), which is the established inhibitor of efflux transporter
P-glycoprotein (Pgp), revealed enhancement of antiproliferative action of the complex in a dose-dependent
manner, and slight arrest of cell cycle in the S phase. Also, a depletion of the glutathione (GSH) level by Lbuthionine-sulfoximine (L-BSO) at sub-toxic concentrations (100 μM) caused an increase of activity of C1 to the
IC50 57.67 ± 6.51 (μM). A morphological analysis in PANC-1 cells by dual acridine orange/ethidium bromide
staining, revealed apoptotic potential of complex C1 and a slower kinetic of cell death induction, suggesting a
different mechanism of action compared to cisplatin.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Drug combination study of novel oxorhenium(V) complexes
VL  - 231
SP  - 111807
DO  - 10.1016/j.jinorgbio.2022.111807
ER  - 
@article{
author = "Petrović, Tamara and Gligorijević, Nevenka and Belaj, Ferdinand and Aranđelović, Sandra and Mihajlović-Lalić, Ljiljana E. and Grgurić-Šipka, Sanja and Poljarević, Jelena",
year = "2022",
abstract = "Three Re(V) complexes of structural formulas [ReOCl2L(PPh3)], where L is pyridine-2-carboxylic acid (C1), 3-
methyl-pyridine-2-carboxylic acid (C2) and 6-methyl-pyridine-2-carboxylic acid (C3) were synthesized and
characterized using NMR, IR spectroscopy and mass spectrometry. Crystal structures of all three complexes have
been additionally confirmed by X-ray analysis. The biological activity has been investigated in the panel of tumor
cell lines A549, PANC-1, MDA-MB-231, MCF-7, LS-174, EAhy.926 and one in non-tumor cell line MRC-5. Only
C1 showed dose-dependent cytotoxic potential, particularly toward triple-negative breast adenocarcinoma cells
MDA-MB-231 with IC50 68.90 ± 1.73 μM and pancreatic adenocarcinoma cells PANC-1 with IC50 69.84 ± 2.3
μM. Both cell lines are characterized by a highly invasive and resistant phenotype. Drug combination studies in
PANC-1 cells with C1 and Verapamil hydrochloride (VRP), which is the established inhibitor of efflux transporter
P-glycoprotein (Pgp), revealed enhancement of antiproliferative action of the complex in a dose-dependent
manner, and slight arrest of cell cycle in the S phase. Also, a depletion of the glutathione (GSH) level by Lbuthionine-sulfoximine (L-BSO) at sub-toxic concentrations (100 μM) caused an increase of activity of C1 to the
IC50 57.67 ± 6.51 (μM). A morphological analysis in PANC-1 cells by dual acridine orange/ethidium bromide
staining, revealed apoptotic potential of complex C1 and a slower kinetic of cell death induction, suggesting a
different mechanism of action compared to cisplatin.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Drug combination study of novel oxorhenium(V) complexes",
volume = "231",
pages = "111807",
doi = "10.1016/j.jinorgbio.2022.111807"
}
Petrović, T., Gligorijević, N., Belaj, F., Aranđelović, S., Mihajlović-Lalić, L. E., Grgurić-Šipka, S.,& Poljarević, J.. (2022). Drug combination study of novel oxorhenium(V) complexes. in Journal of Inorganic Biochemistry
Elsevier., 231, 111807.
https://doi.org/10.1016/j.jinorgbio.2022.111807
Petrović T, Gligorijević N, Belaj F, Aranđelović S, Mihajlović-Lalić LE, Grgurić-Šipka S, Poljarević J. Drug combination study of novel oxorhenium(V) complexes. in Journal of Inorganic Biochemistry. 2022;231:111807.
doi:10.1016/j.jinorgbio.2022.111807 .
Petrović, Tamara, Gligorijević, Nevenka, Belaj, Ferdinand, Aranđelović, Sandra, Mihajlović-Lalić, Ljiljana E., Grgurić-Šipka, Sanja, Poljarević, Jelena, "Drug combination study of novel oxorhenium(V) complexes" in Journal of Inorganic Biochemistry, 231 (2022):111807,
https://doi.org/10.1016/j.jinorgbio.2022.111807 . .
2

Drug combination study of novel oxorhenium(V) complexes

Petrović, Tamara; Gligorijević, Nevenka; Belaj, Ferdinand; Aranđelović, Sandra; Mihajlović-Lalić, Ljiljana E.; Grgurić-Šipka, Sanja; Poljarević, Jelena

(Elsevier, 2022)

TY  - JOUR
AU  - Petrović, Tamara
AU  - Gligorijević, Nevenka
AU  - Belaj, Ferdinand
AU  - Aranđelović, Sandra
AU  - Mihajlović-Lalić, Ljiljana E.
AU  - Grgurić-Šipka, Sanja
AU  - Poljarević, Jelena
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5047
AB  - Three Re(V) complexes of structural formulas [ReOCl2L(PPh3)], where L is pyridine-2-carboxylic acid (C1), 3-methyl-pyridine-2-carboxylic acid (C2) and 6-methyl-pyridine-2-carboxylic acid (C3) were synthesized andcharacterized using NMR, IR spectroscopy and mass spectrometry. Crystal structures of all three complexes havebeen additionally confirmed by X-ray analysis. The biological activity has been investigated in the panel of tumorcell lines A549, PANC-1, MDA-MB-231, MCF-7, LS-174, EAhy.926 and one in non-tumor cell line MRC-5. OnlyC1 showed dose-dependent cytotoxic potential, particularly toward triple-negative breast adenocarcinoma cellsMDA-MB-231 with IC50 68.90 ± 1.73 μM and pancreatic adenocarcinoma cells PANC-1 with IC50 69.84 ± 2.3μM. Both cell lines are characterized by a highly invasive and resistant phenotype. Drug combination studies inPANC-1 cells with C1 and Verapamil hydrochloride (VRP), which is the established inhibitor of efflux transporterP-glycoprotein (Pgp), revealed enhancement of antiproliferative action of the complex in a dose-dependentmanner, and slight arrest of cell cycle in the S phase. Also, a depletion of the glutathione (GSH) level by Lbuthionine-sulfoximine (L-BSO) at sub-toxic concentrations (100 μM) caused an increase of activity of C1 to theIC50 57.67 ± 6.51 (μM). A morphological analysis in PANC-1 cells by dual acridine orange/ethidium bromidestaining, revealed apoptotic potential of complex C1 and a slower kinetic of cell death induction, suggesting adifferent mechanism of action compared to cisplatin.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Drug combination study of novel oxorhenium(V) complexes
VL  - 231
SP  - 111807
DO  - 10.1016/j.jinorgbio.2022.111807
ER  - 
@article{
author = "Petrović, Tamara and Gligorijević, Nevenka and Belaj, Ferdinand and Aranđelović, Sandra and Mihajlović-Lalić, Ljiljana E. and Grgurić-Šipka, Sanja and Poljarević, Jelena",
year = "2022",
abstract = "Three Re(V) complexes of structural formulas [ReOCl2L(PPh3)], where L is pyridine-2-carboxylic acid (C1), 3-methyl-pyridine-2-carboxylic acid (C2) and 6-methyl-pyridine-2-carboxylic acid (C3) were synthesized andcharacterized using NMR, IR spectroscopy and mass spectrometry. Crystal structures of all three complexes havebeen additionally confirmed by X-ray analysis. The biological activity has been investigated in the panel of tumorcell lines A549, PANC-1, MDA-MB-231, MCF-7, LS-174, EAhy.926 and one in non-tumor cell line MRC-5. OnlyC1 showed dose-dependent cytotoxic potential, particularly toward triple-negative breast adenocarcinoma cellsMDA-MB-231 with IC50 68.90 ± 1.73 μM and pancreatic adenocarcinoma cells PANC-1 with IC50 69.84 ± 2.3μM. Both cell lines are characterized by a highly invasive and resistant phenotype. Drug combination studies inPANC-1 cells with C1 and Verapamil hydrochloride (VRP), which is the established inhibitor of efflux transporterP-glycoprotein (Pgp), revealed enhancement of antiproliferative action of the complex in a dose-dependentmanner, and slight arrest of cell cycle in the S phase. Also, a depletion of the glutathione (GSH) level by Lbuthionine-sulfoximine (L-BSO) at sub-toxic concentrations (100 μM) caused an increase of activity of C1 to theIC50 57.67 ± 6.51 (μM). A morphological analysis in PANC-1 cells by dual acridine orange/ethidium bromidestaining, revealed apoptotic potential of complex C1 and a slower kinetic of cell death induction, suggesting adifferent mechanism of action compared to cisplatin.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Drug combination study of novel oxorhenium(V) complexes",
volume = "231",
pages = "111807",
doi = "10.1016/j.jinorgbio.2022.111807"
}
Petrović, T., Gligorijević, N., Belaj, F., Aranđelović, S., Mihajlović-Lalić, L. E., Grgurić-Šipka, S.,& Poljarević, J.. (2022). Drug combination study of novel oxorhenium(V) complexes. in Journal of Inorganic Biochemistry
Elsevier., 231, 111807.
https://doi.org/10.1016/j.jinorgbio.2022.111807
Petrović T, Gligorijević N, Belaj F, Aranđelović S, Mihajlović-Lalić LE, Grgurić-Šipka S, Poljarević J. Drug combination study of novel oxorhenium(V) complexes. in Journal of Inorganic Biochemistry. 2022;231:111807.
doi:10.1016/j.jinorgbio.2022.111807 .
Petrović, Tamara, Gligorijević, Nevenka, Belaj, Ferdinand, Aranđelović, Sandra, Mihajlović-Lalić, Ljiljana E., Grgurić-Šipka, Sanja, Poljarević, Jelena, "Drug combination study of novel oxorhenium(V) complexes" in Journal of Inorganic Biochemistry, 231 (2022):111807,
https://doi.org/10.1016/j.jinorgbio.2022.111807 . .
2

Strong Hydrogen Bonds of Coordinated Ammonia Molecules

Živković, Jelena M.; Veljković, Dušan Ž.; Zarić, Snežana D.

(ACS, 2022)

TY  - JOUR
AU  - Živković, Jelena M.
AU  - Veljković, Dušan Ž.
AU  - Zarić, Snežana D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4998
AB  - The hydrogen bonds of noncoordinated (NH/O) and coordinated ammonia (MLNH/O) with water molecules were studied by analyzing data in the Cambridge Structural Database (CSD) and by DFT calculations. The data from the CSD on the distribution of hydrogen bond dHO distances of the coordinated ammonia show a peak in the range of 2.0–2.2 Å with a significant number of hydrogen bonds in the range of 1.8–2.0 Å. Analysis of Hirshfeld surfaces showed that coordinated NH3 molecules are involved in numerous noncovalent contacts. The DFT calculations were performed on linear complexes of silver(I), square-planar complexes of platinum(II), tetrahedral complexes of zinc(II), and octahedral complexes of cobalt(III) by varying the charge of the complexes. The calculated data show that coordinated ammonia has stronger hydrogen bonds than noncoordinated ammonia, even for neutral complexes. The hydrogen bond energy of noncoordinated ammonia is −2.3 kcal/mol, while for coordinated ammonia, attractive interactions are in the range of −3.7 to −25.0 kcal/mol, depending on the metal ion and charge of the complex. The interaction energies for metal complexes from neutral to charged species are for the linear silver(I) complex from −6.0 to −10.7 kcal/mol, while for the square planar complex, interactions span from −5.9 to −19.9 kcal/mol. The tetrahedral zinc(II) complexes have interaction energy from −5.5 to −17.5 kcal/mol, while for the octahedral cobalt(III) complex, attractive interaction energies are from −3.7 to −25.0 kcal/mol. With the increasing charge of the metal complex, the hydrogen bond between coordinated ammonia and free water becomes stronger, and in accordance with that, the dHO distance becomes shorter. The bifurcated interaction is stronger than monofurcated for all complexes. The interaction energies correspond well with the electrostatic potential (Vs) values on interacting hydrogen atoms; the more positive Vs values on hydrogen atoms lead to stronger interaction. The hydrogen bond between ammonia and water molecules (−2.3 kcal/mol) is quite weak in comparison to the water/water hydrogen bond; it is 50% of the water/water hydrogen bond (−4.84 kcal/mol). Although the hydrogen bonds of coordinated ammonia are also weaker than hydrogen bonds of coordinated water molecules, the difference is smaller, indicating the importance of the coordination on the strength of hydrogen bonds.
PB  - ACS
T2  - Crystal Growth and Design
T1  - Strong Hydrogen Bonds of Coordinated Ammonia Molecules
VL  - 22
IS  - 1
SP  - 148
EP  - 158
DO  - 10.1021/acs.cgd.1c00685
ER  - 
@article{
author = "Živković, Jelena M. and Veljković, Dušan Ž. and Zarić, Snežana D.",
year = "2022",
abstract = "The hydrogen bonds of noncoordinated (NH/O) and coordinated ammonia (MLNH/O) with water molecules were studied by analyzing data in the Cambridge Structural Database (CSD) and by DFT calculations. The data from the CSD on the distribution of hydrogen bond dHO distances of the coordinated ammonia show a peak in the range of 2.0–2.2 Å with a significant number of hydrogen bonds in the range of 1.8–2.0 Å. Analysis of Hirshfeld surfaces showed that coordinated NH3 molecules are involved in numerous noncovalent contacts. The DFT calculations were performed on linear complexes of silver(I), square-planar complexes of platinum(II), tetrahedral complexes of zinc(II), and octahedral complexes of cobalt(III) by varying the charge of the complexes. The calculated data show that coordinated ammonia has stronger hydrogen bonds than noncoordinated ammonia, even for neutral complexes. The hydrogen bond energy of noncoordinated ammonia is −2.3 kcal/mol, while for coordinated ammonia, attractive interactions are in the range of −3.7 to −25.0 kcal/mol, depending on the metal ion and charge of the complex. The interaction energies for metal complexes from neutral to charged species are for the linear silver(I) complex from −6.0 to −10.7 kcal/mol, while for the square planar complex, interactions span from −5.9 to −19.9 kcal/mol. The tetrahedral zinc(II) complexes have interaction energy from −5.5 to −17.5 kcal/mol, while for the octahedral cobalt(III) complex, attractive interaction energies are from −3.7 to −25.0 kcal/mol. With the increasing charge of the metal complex, the hydrogen bond between coordinated ammonia and free water becomes stronger, and in accordance with that, the dHO distance becomes shorter. The bifurcated interaction is stronger than monofurcated for all complexes. The interaction energies correspond well with the electrostatic potential (Vs) values on interacting hydrogen atoms; the more positive Vs values on hydrogen atoms lead to stronger interaction. The hydrogen bond between ammonia and water molecules (−2.3 kcal/mol) is quite weak in comparison to the water/water hydrogen bond; it is 50% of the water/water hydrogen bond (−4.84 kcal/mol). Although the hydrogen bonds of coordinated ammonia are also weaker than hydrogen bonds of coordinated water molecules, the difference is smaller, indicating the importance of the coordination on the strength of hydrogen bonds.",
publisher = "ACS",
journal = "Crystal Growth and Design",
title = "Strong Hydrogen Bonds of Coordinated Ammonia Molecules",
volume = "22",
number = "1",
pages = "148-158",
doi = "10.1021/acs.cgd.1c00685"
}
Živković, J. M., Veljković, D. Ž.,& Zarić, S. D.. (2022). Strong Hydrogen Bonds of Coordinated Ammonia Molecules. in Crystal Growth and Design
ACS., 22(1), 148-158.
https://doi.org/10.1021/acs.cgd.1c00685
Živković JM, Veljković DŽ, Zarić SD. Strong Hydrogen Bonds of Coordinated Ammonia Molecules. in Crystal Growth and Design. 2022;22(1):148-158.
doi:10.1021/acs.cgd.1c00685 .
Živković, Jelena M., Veljković, Dušan Ž., Zarić, Snežana D., "Strong Hydrogen Bonds of Coordinated Ammonia Molecules" in Crystal Growth and Design, 22, no. 1 (2022):148-158,
https://doi.org/10.1021/acs.cgd.1c00685 . .
2
1

Levels of non-essential trace metals and their impact on placental health: a review

Stojsavljević, Aleksandar; Perović, Milan; Nešić, Andrijana N.; Miković, Željko; Manojlović, Dragan D.

(SpringerLink, 2022)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Perović, Milan
AU  - Nešić, Andrijana N.
AU  - Miković, Željko
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - https://link.springer.com/article/10.1007/s11356-022-20205-1
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5116
AB  - According to recent research, even low levels of environmental chemicals, particularly heavy metals, can considerably disrupt placental homeostasis. This review aims to explore the profile of non-essential trace metals in placental tissues across the globe and to specify trace metal(s) that can be candidates for impaired placental health. Accordingly, we conducted an extensive survey on relevant databases of peer-reviewed papers published in the last two decades. Among a considerable number of non-essential trace metals, arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) were identified as the most detrimental to placental health. Comparative analysis showed remarkable differences in placental levels of these trace metals worldwide. Based on current data reported across the globe, a median (min–max) range from 0.55 to 15 ng/g for placental As levels could be deemed safe. The placental Cd and Pb levels were markedly higher in smokers than in non-smokers. Occupationally exposed pregnant women had several orders of magnitude higher Cd, Pb, and Hg levels in placental tissues than non-occupationally exposed women. Also, we concluded that even low-level exposure to As, Cd, Pb, and Hg could be deleterious to proper fetal development. This review implies the need to reduce exposure to non-essential trace metals to preserve placental health and prevent numerous poor pregnancy outcomes. Overall, the information presented is expected to help plan future fundamental and applied investigations on the placental toxicity of As, Cd, Pb, and Hg. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PB  - SpringerLink
T2  - Environmental Science and Pollution Research
T1  - Levels of non-essential trace metals and their impact on placental health: a review
VL  - n/a
DO  - 10.1007/s11356-022-20205-1
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Perović, Milan and Nešić, Andrijana N. and Miković, Željko and Manojlović, Dragan D.",
year = "2022",
abstract = "According to recent research, even low levels of environmental chemicals, particularly heavy metals, can considerably disrupt placental homeostasis. This review aims to explore the profile of non-essential trace metals in placental tissues across the globe and to specify trace metal(s) that can be candidates for impaired placental health. Accordingly, we conducted an extensive survey on relevant databases of peer-reviewed papers published in the last two decades. Among a considerable number of non-essential trace metals, arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) were identified as the most detrimental to placental health. Comparative analysis showed remarkable differences in placental levels of these trace metals worldwide. Based on current data reported across the globe, a median (min–max) range from 0.55 to 15 ng/g for placental As levels could be deemed safe. The placental Cd and Pb levels were markedly higher in smokers than in non-smokers. Occupationally exposed pregnant women had several orders of magnitude higher Cd, Pb, and Hg levels in placental tissues than non-occupationally exposed women. Also, we concluded that even low-level exposure to As, Cd, Pb, and Hg could be deleterious to proper fetal development. This review implies the need to reduce exposure to non-essential trace metals to preserve placental health and prevent numerous poor pregnancy outcomes. Overall, the information presented is expected to help plan future fundamental and applied investigations on the placental toxicity of As, Cd, Pb, and Hg. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
publisher = "SpringerLink",
journal = "Environmental Science and Pollution Research",
title = "Levels of non-essential trace metals and their impact on placental health: a review",
volume = "n/a",
doi = "10.1007/s11356-022-20205-1"
}
Stojsavljević, A., Perović, M., Nešić, A. N., Miković, Ž.,& Manojlović, D. D.. (2022). Levels of non-essential trace metals and their impact on placental health: a review. in Environmental Science and Pollution Research
SpringerLink., n/a.
https://doi.org/10.1007/s11356-022-20205-1
Stojsavljević A, Perović M, Nešić AN, Miković Ž, Manojlović DD. Levels of non-essential trace metals and their impact on placental health: a review. in Environmental Science and Pollution Research. 2022;n/a.
doi:10.1007/s11356-022-20205-1 .
Stojsavljević, Aleksandar, Perović, Milan, Nešić, Andrijana N., Miković, Željko, Manojlović, Dragan D., "Levels of non-essential trace metals and their impact on placental health: a review" in Environmental Science and Pollution Research, n/a (2022),
https://doi.org/10.1007/s11356-022-20205-1 . .

Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood

Stojsavljević, Aleksandar; Rovčanin, Marija; Miković, Željko; Perović, Milan; Jeremić, Ana; Zečević, Nebojša; Manojlović, Dragan D.

(Springer, 2022)

TY  - JOUR
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Miković, Željko
AU  - Perović, Milan
AU  - Jeremić, Ana
AU  - Zečević, Nebojša
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4879
AB  - Progressive industrialization in recent decades has contributed to the increase of metal levels in the environment, which has a dangerous impact on human health, primarily pregnant women. In this study, we aimed to compare levels of various elements in maternal and umbilical cord (UC) plasma samples collected from 125 healthy pregnant women, conduct correlation analysis among paired plasma samples, and compare our data with other populations worldwide. The study design included the following elements: essential (Mn, Co, Cu, Zn, Se, Mo), non-essential (Be, Al, Ni, As, Rb, Sr, Cd, Sb, Pb, U), rare earth (La, Pr, Ce, Nd, Sm, Eu, Gd, Dy, Ho, Er), and noble metals (Ru, Rh, Re, Pt). Levels of 30 elements were higher in maternal plasma than in UC plasma samples. However, no disparities at the statistically significant level were found for Be, Zn, Rb, Cd, Ce, and Ho. Correlation analysis among paired plasma samples revealed only positive/synergistic correlations of different strengths between most elements. Compared to other countries across the globe, our participants had considerably lower plasma levels of Zn and higher levels of Co, Ni, and As. This study provides not only a new and deeper comprehension, but also the first insight into the levels, correlation, distribution, and potential transplacental transfer of 30 elements.
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood
VL  - n/a
DO  - 10.1007/s11356-021-18190-y
ER  - 
@article{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Miković, Željko and Perović, Milan and Jeremić, Ana and Zečević, Nebojša and Manojlović, Dragan D.",
year = "2022",
abstract = "Progressive industrialization in recent decades has contributed to the increase of metal levels in the environment, which has a dangerous impact on human health, primarily pregnant women. In this study, we aimed to compare levels of various elements in maternal and umbilical cord (UC) plasma samples collected from 125 healthy pregnant women, conduct correlation analysis among paired plasma samples, and compare our data with other populations worldwide. The study design included the following elements: essential (Mn, Co, Cu, Zn, Se, Mo), non-essential (Be, Al, Ni, As, Rb, Sr, Cd, Sb, Pb, U), rare earth (La, Pr, Ce, Nd, Sm, Eu, Gd, Dy, Ho, Er), and noble metals (Ru, Rh, Re, Pt). Levels of 30 elements were higher in maternal plasma than in UC plasma samples. However, no disparities at the statistically significant level were found for Be, Zn, Rb, Cd, Ce, and Ho. Correlation analysis among paired plasma samples revealed only positive/synergistic correlations of different strengths between most elements. Compared to other countries across the globe, our participants had considerably lower plasma levels of Zn and higher levels of Co, Ni, and As. This study provides not only a new and deeper comprehension, but also the first insight into the levels, correlation, distribution, and potential transplacental transfer of 30 elements.",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood",
volume = "n/a",
doi = "10.1007/s11356-021-18190-y"
}
Stojsavljević, A., Rovčanin, M., Miković, Ž., Perović, M., Jeremić, A., Zečević, N.,& Manojlović, D. D.. (2022). Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood. in Environmental Science and Pollution Research
Springer., n/a.
https://doi.org/10.1007/s11356-021-18190-y
Stojsavljević A, Rovčanin M, Miković Ž, Perović M, Jeremić A, Zečević N, Manojlović DD. Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood. in Environmental Science and Pollution Research. 2022;n/a.
doi:10.1007/s11356-021-18190-y .
Stojsavljević, Aleksandar, Rovčanin, Marija, Miković, Željko, Perović, Milan, Jeremić, Ana, Zečević, Nebojša, Manojlović, Dragan D., "Analysis of essential, toxic, rare earth, and noble elements in maternal and umbilical cord blood" in Environmental Science and Pollution Research, n/a (2022),
https://doi.org/10.1007/s11356-021-18190-y . .
4
1

Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.

Stojsavljević, Aleksandar; Rovčanin, Marija; Miković, Željko; Perović, Milan; Jeremić, Ana; Zečević, Nebojša; Manojlović, Dragan D.

(Springer, 2022)

TY  - DATA
AU  - Stojsavljević, Aleksandar
AU  - Rovčanin, Marija
AU  - Miković, Željko
AU  - Perović, Milan
AU  - Jeremić, Ana
AU  - Zečević, Nebojša
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4880
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4880
ER  - 
@misc{
author = "Stojsavljević, Aleksandar and Rovčanin, Marija and Miković, Željko and Perović, Milan and Jeremić, Ana and Zečević, Nebojša and Manojlović, Dragan D.",
year = "2022",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4880"
}
Stojsavljević, A., Rovčanin, M., Miković, Ž., Perović, M., Jeremić, A., Zečević, N.,& Manojlović, D. D.. (2022). Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.. in Environmental Science and Pollution Research
Springer..
https://hdl.handle.net/21.15107/rcub_cherry_4880
Stojsavljević A, Rovčanin M, Miković Ž, Perović M, Jeremić A, Zečević N, Manojlović DD. Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y.. in Environmental Science and Pollution Research. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_4880 .
Stojsavljević, Aleksandar, Rovčanin, Marija, Miković, Željko, Perović, Milan, Jeremić, Ana, Zečević, Nebojša, Manojlović, Dragan D., "Supplementary data for the article: Stojsavljević, A.; Rovčanin, M.; Miković, Ž.; Perović, M.; Jeremić, A.; Zečević, N.; Manojlović, D. Analysis of Essential, Toxic, Rare Earth, and Noble Elements in Maternal and Umbilical Cord Blood. Environ Sci Pollut Res 2022. https://doi.org/10.1007/s11356-021-18190-y." in Environmental Science and Pollution Research (2022),
https://hdl.handle.net/21.15107/rcub_cherry_4880 .

Supplementary information for the article: Filipović, L.; Spasojević, M.; Prodanović, R.; Korać, A.; Matijaševic, S.; Brajušković, G.; de Marco, A.; Popović, M. Affinity-Based Isolation of Extracellular Vesicles by Means of Single-Domain Antibodies Bound to Macroporous Methacrylate-Based Copolymer. New Biotechnology 2022, 69, 36–48. https://doi.org/10.1016/j.nbt.2022.03.001.

Filipović, Lidija; Spasojević, Milica; Prodanović, Radivoje; Korać, Aleksandra; Matijaševic, Suzana; Brajušković, Goran; de Marco, Ario; Popović, Milica

(Elsevier, 2022)

TY  - DATA
AU  - Filipović, Lidija
AU  - Spasojević, Milica
AU  - Prodanović, Radivoje
AU  - Korać, Aleksandra
AU  - Matijaševic, Suzana
AU  - Brajušković, Goran
AU  - de Marco, Ario
AU  - Popović, Milica
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5152
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5153
AB  - Correct elucidation of physiological and pathological processes mediated by extracellular vesicles (EV) is highly dependent on the reliability of the method used for their purification. Currently available chemical/physical protocols for sample fractionation are time-consuming, often scarcely reproducible and their yields are low. Immuno-capture based approaches could represent an effective purification alternative to obtain homogeneous EV samples. An easy-to-operate chromatography system was set-up for the purification of intact EVs based on a single domain (VHH) antibodies-copolymer matrix suitable for biological samples as different as conditioned cell culture medium and human plasma. Methacrylate-based copolymer is a porous solid support, the chemical versatility of which enables its efficient functionalization with VHHs. The combined analyses of morphological features and biomarker (CD9, CD63 and CD81) presence indicated that the recovered EVs were exosomes. The lipoprotein markers APO-A1 and APO-B were both negative in tested samples. This is the first report demonstrating the successful application of spherical porous methacrylate-based copolymer coupled with VHHs for the exosome isolation from biological fluids. This inexpensive immunoaffinity method has the potential to be applied for the isolation of EVs belonging to different morphological and physiological classes.
PB  - Elsevier
T2  - New Biotechnology
T1  - Supplementary information for the article: Filipović, L.; Spasojević, M.; Prodanović, R.; Korać, A.; Matijaševic, S.; Brajušković, G.; de Marco, A.; Popović, M. Affinity-Based Isolation of Extracellular Vesicles by Means of Single-Domain Antibodies Bound to Macroporous Methacrylate-Based Copolymer. New Biotechnology 2022, 69, 36–48. https://doi.org/10.1016/j.nbt.2022.03.001.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5153
ER  - 
@misc{
author = "Filipović, Lidija and Spasojević, Milica and Prodanović, Radivoje and Korać, Aleksandra and Matijaševic, Suzana and Brajušković, Goran and de Marco, Ario and Popović, Milica",
year = "2022",
abstract = "Correct elucidation of physiological and pathological processes mediated by extracellular vesicles (EV) is highly dependent on the reliability of the method used for their purification. Currently available chemical/physical protocols for sample fractionation are time-consuming, often scarcely reproducible and their yields are low. Immuno-capture based approaches could represent an effective purification alternative to obtain homogeneous EV samples. An easy-to-operate chromatography system was set-up for the purification of intact EVs based on a single domain (VHH) antibodies-copolymer matrix suitable for biological samples as different as conditioned cell culture medium and human plasma. Methacrylate-based copolymer is a porous solid support, the chemical versatility of which enables its efficient functionalization with VHHs. The combined analyses of morphological features and biomarker (CD9, CD63 and CD81) presence indicated that the recovered EVs were exosomes. The lipoprotein markers APO-A1 and APO-B were both negative in tested samples. This is the first report demonstrating the successful application of spherical porous methacrylate-based copolymer coupled with VHHs for the exosome isolation from biological fluids. This inexpensive immunoaffinity method has the potential to be applied for the isolation of EVs belonging to different morphological and physiological classes.",
publisher = "Elsevier",
journal = "New Biotechnology",
title = "Supplementary information for the article: Filipović, L.; Spasojević, M.; Prodanović, R.; Korać, A.; Matijaševic, S.; Brajušković, G.; de Marco, A.; Popović, M. Affinity-Based Isolation of Extracellular Vesicles by Means of Single-Domain Antibodies Bound to Macroporous Methacrylate-Based Copolymer. New Biotechnology 2022, 69, 36–48. https://doi.org/10.1016/j.nbt.2022.03.001.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5153"
}
Filipović, L., Spasojević, M., Prodanović, R., Korać, A., Matijaševic, S., Brajušković, G., de Marco, A.,& Popović, M.. (2022). Supplementary information for the article: Filipović, L.; Spasojević, M.; Prodanović, R.; Korać, A.; Matijaševic, S.; Brajušković, G.; de Marco, A.; Popović, M. Affinity-Based Isolation of Extracellular Vesicles by Means of Single-Domain Antibodies Bound to Macroporous Methacrylate-Based Copolymer. New Biotechnology 2022, 69, 36–48. https://doi.org/10.1016/j.nbt.2022.03.001.. in New Biotechnology
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_5153
Filipović L, Spasojević M, Prodanović R, Korać A, Matijaševic S, Brajušković G, de Marco A, Popović M. Supplementary information for the article: Filipović, L.; Spasojević, M.; Prodanović, R.; Korać, A.; Matijaševic, S.; Brajušković, G.; de Marco, A.; Popović, M. Affinity-Based Isolation of Extracellular Vesicles by Means of Single-Domain Antibodies Bound to Macroporous Methacrylate-Based Copolymer. New Biotechnology 2022, 69, 36–48. https://doi.org/10.1016/j.nbt.2022.03.001.. in New Biotechnology. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_5153 .
Filipović, Lidija, Spasojević, Milica, Prodanović, Radivoje, Korać, Aleksandra, Matijaševic, Suzana, Brajušković, Goran, de Marco, Ario, Popović, Milica, "Supplementary information for the article: Filipović, L.; Spasojević, M.; Prodanović, R.; Korać, A.; Matijaševic, S.; Brajušković, G.; de Marco, A.; Popović, M. Affinity-Based Isolation of Extracellular Vesicles by Means of Single-Domain Antibodies Bound to Macroporous Methacrylate-Based Copolymer. New Biotechnology 2022, 69, 36–48. https://doi.org/10.1016/j.nbt.2022.03.001." in New Biotechnology (2022),
https://hdl.handle.net/21.15107/rcub_cherry_5153 .