TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana 
AU  - Kostić-Rajačić, Slađana
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 

@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana  and Kostić-Rajačić, Slađana",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}

Penjišević, J., Šukalović, V., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D.,& Kostić-Rajačić, S..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845

Penjišević J, Šukalović V, Dukić-Stefanović S, Deuther-Conrad W, Andrić D, Kostić-Rajačić S. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

Penjišević, Jelena , Šukalović, Vladimir , Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana , Kostić-Rajačić, Slađana, "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

TY  - DATA
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Bošković, Jakša
AU  - Baranac-Stojanović, Marija
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5846
AB  - We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.
PB  - Royal Society of Chemistry
T2  - Organic & Biomolecular Chemistry
T1  - Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F
VL  - 21
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5846
ER  - 

@misc{
author = "Aleksić, Jovana and Stojanović, Milovan and Bošković, Jakša and Baranac-Stojanović, Marija",
abstract = "We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.",
publisher = "Royal Society of Chemistry",
journal = "Organic & Biomolecular Chemistry",
title = "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F",
volume = "21",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5846"
}

Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M..Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846

Aleksić J, Stojanović M, Bošković J, Baranac-Stojanović M. Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry.21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

Aleksić, Jovana, Stojanović, Milovan, Bošković, Jakša, Baranac-Stojanović, Marija, "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F" in Organic & Biomolecular Chemistry, 21, no. 6,
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

TY  - CONF
AU  - Milovanović, Milan R.
AU  - Nikolić, Stefan R.
AU  - Dupé, Antoine
AU  - Poljarević, Jelena M.
AU  - Schachner, Jörg A.
PY  - 2024-06
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6559
AB  - A lot of scientific effort was dedicated to research into a cure for cancer over past 
decades. Many of them failed due to a low solubility of synthetized compounds or low 
selectivity between healthy and pathogenic cells. It was shown that apigenin, a natural 
pigment of chamomile, showed some cytotoxic activity itself,[1] however, its extremely 
low solubility in water is a limiting factor in its use as a potential anticancer drug.
Here, we present a crystal structure of the first Re(V) complex containing apigenin 
– a natural occurring ligand. Various types of non-covalent interactions were found in 
the crystal structure (Figure 1). Namely, there are a couple of different hydrogen bonds 
(i.e. mono and bifurcated O-H∙∙∙O; O-H∙∙∙Cl; C-H∙∙∙Cl), T-shaped C-H∙∙∙π and π∙∙∙π 
stacking interactions. At least some of these interactions could be responsible for 
compounds’ final mechanism of anticancer action.
C3  - 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia
T1  - The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6559
ER  - 

@conference{
author = "Milovanović, Milan R. and Nikolić, Stefan R. and Dupé, Antoine and Poljarević, Jelena M. and Schachner, Jörg A.",
year = "2024-06",
abstract = "A lot of scientific effort was dedicated to research into a cure for cancer over past 
decades. Many of them failed due to a low solubility of synthetized compounds or low 
selectivity between healthy and pathogenic cells. It was shown that apigenin, a natural 
pigment of chamomile, showed some cytotoxic activity itself,[1] however, its extremely 
low solubility in water is a limiting factor in its use as a potential anticancer drug.
Here, we present a crystal structure of the first Re(V) complex containing apigenin 
– a natural occurring ligand. Various types of non-covalent interactions were found in 
the crystal structure (Figure 1). Namely, there are a couple of different hydrogen bonds 
(i.e. mono and bifurcated O-H∙∙∙O; O-H∙∙∙Cl; C-H∙∙∙Cl), T-shaped C-H∙∙∙π and π∙∙∙π 
stacking interactions. At least some of these interactions could be responsible for 
compounds’ final mechanism of anticancer action.",
journal = "3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia",
title = "The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6559"
}

Milovanović, M. R., Nikolić, S. R., Dupé, A., Poljarević, J. M.,& Schachner, J. A.. (2024-06). The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure. in 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia.
https://hdl.handle.net/21.15107/rcub_cherry_6559

Milovanović MR, Nikolić SR, Dupé A, Poljarević JM, Schachner JA. The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure. in 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia. 2024;.
https://hdl.handle.net/21.15107/rcub_cherry_6559 .

Milovanović, Milan R., Nikolić, Stefan R., Dupé, Antoine, Poljarević, Jelena M., Schachner, Jörg A., "The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure" in 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia (2024-06),
https://hdl.handle.net/21.15107/rcub_cherry_6559 .

TY  - JOUR
AU  - Vukićević, Emilija
AU  - Isailović, Jelena
AU  - Gajica, Gordana
AU  - Antić, Vesna
AU  - Jovančićević, Branimir
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6620
AB  - The stalks left after harvesting corn, tomatoes, and tobacco have nofurther use and are usually burned on agricultural land. In our work samples ofthis waste were collected and pyrolyzed at 400 ℃ for 30 min in a nitrogenatmosphere. The solid residue (biochar) obtained by pyrolysis was analyzed,and the results were compared with widely used solid fuels such as wood, coal,coke and charcoal. The heat values of biochar from tomato, tobacco, corn ZP6263, and corn BC 398 stalks were 24.12, 23.09, 26.24 and 25.78 MJ kg-1, respectively.These values are significantly higher than the heat value of wood,which is about 12.50 MJ kg-1. The ash content of biochar was 12–20 %, whichis consistent with the ash content of solid fuels. No heavy metals were found inbiochar samples. The results show that biochar obtained from the pyrolysis ofagricultural waste, such as tomatoes, tobacco and corn stalks, has good potentialfor use as a solid fuel.
AB  - Стабљике које остају након жетве кукуруза и дувана, као и брања парадајза,немају даљу употребу и обично се спаљују на пољопривредном земљишту. Унашем раду узорци овог отпада су прикупљени и пиролизовани на 400 ℃ у атмо-сфери азота током 30 min. Анализиран је чврсти остатак (биоугаљ) добијен пиро-лизом, а резултати су упоређени са широко коришћеним конвенционалним чврс-тим горивима као што су дрво, угаљ, кокс и дрвени угаљ. Калоријске вредностибиоугља из стабљика парадајза, дувана, кукуруза ZP 6263 и кукуруза BC 398 билесу 24,12, 23,09, 26,24 и 25,78 МЈ kg-1. Ове вредности су знатно веће од калоријскевредности дрвета која износи око 12,50 МЈ kg-1. Садржај пепела у биоугљу је био12–20 %, што је у складу са садржајем пепела код чврстих горива. У узорцима био-угља нису пронађени тешки метали. Резултати показују да биоугаљ добијен пиро-лизом пољопривредног отпада, као што су стабљике парадајза, дувана и кукуруза,има добар потенцијал за употребу као чврсто гориво.
PB  - Srpsko hemijsko društvo
T2  - Journal of the Serbian Chemical Society
T1  - Biochar from agricultural biomass: Green material as an ecological alternative to solid fossil fuels
T1  - Биоугаљ из пољопривредне биомасе: зелени материјал као еколошка алтернатива чврстим фосилним горивима
VL  - 89
IS  - 6
SP  - 907
EP  - 919
DO  - 10.2298/JSC240126048V
ER  - 

@article{
author = "Vukićević, Emilija and Isailović, Jelena and Gajica, Gordana and Antić, Vesna and Jovančićević, Branimir",
year = "2024",
abstract = "The stalks left after harvesting corn, tomatoes, and tobacco have nofurther use and are usually burned on agricultural land. In our work samples ofthis waste were collected and pyrolyzed at 400 ℃ for 30 min in a nitrogenatmosphere. The solid residue (biochar) obtained by pyrolysis was analyzed,and the results were compared with widely used solid fuels such as wood, coal,coke and charcoal. The heat values of biochar from tomato, tobacco, corn ZP6263, and corn BC 398 stalks were 24.12, 23.09, 26.24 and 25.78 MJ kg-1, respectively.These values are significantly higher than the heat value of wood,which is about 12.50 MJ kg-1. The ash content of biochar was 12–20 %, whichis consistent with the ash content of solid fuels. No heavy metals were found inbiochar samples. The results show that biochar obtained from the pyrolysis ofagricultural waste, such as tomatoes, tobacco and corn stalks, has good potentialfor use as a solid fuel., Стабљике које остају након жетве кукуруза и дувана, као и брања парадајза,немају даљу употребу и обично се спаљују на пољопривредном земљишту. Унашем раду узорци овог отпада су прикупљени и пиролизовани на 400 ℃ у атмо-сфери азота током 30 min. Анализиран је чврсти остатак (биоугаљ) добијен пиро-лизом, а резултати су упоређени са широко коришћеним конвенционалним чврс-тим горивима као што су дрво, угаљ, кокс и дрвени угаљ. Калоријске вредностибиоугља из стабљика парадајза, дувана, кукуруза ZP 6263 и кукуруза BC 398 билесу 24,12, 23,09, 26,24 и 25,78 МЈ kg-1. Ове вредности су знатно веће од калоријскевредности дрвета која износи око 12,50 МЈ kg-1. Садржај пепела у биоугљу је био12–20 %, што је у складу са садржајем пепела код чврстих горива. У узорцима био-угља нису пронађени тешки метали. Резултати показују да биоугаљ добијен пиро-лизом пољопривредног отпада, као што су стабљике парадајза, дувана и кукуруза,има добар потенцијал за употребу као чврсто гориво.",
publisher = "Srpsko hemijsko društvo",
journal = "Journal of the Serbian Chemical Society",
title = "Biochar from agricultural biomass: Green material as an ecological alternative to solid fossil fuels, Биоугаљ из пољопривредне биомасе: зелени материјал као еколошка алтернатива чврстим фосилним горивима",
volume = "89",
number = "6",
pages = "907-919",
doi = "10.2298/JSC240126048V"
}

Vukićević, E., Isailović, J., Gajica, G., Antić, V.,& Jovančićević, B.. (2024). Biochar from agricultural biomass: Green material as an ecological alternative to solid fossil fuels. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo., 89(6), 907-919.
https://doi.org/10.2298/JSC240126048V

Vukićević E, Isailović J, Gajica G, Antić V, Jovančićević B. Biochar from agricultural biomass: Green material as an ecological alternative to solid fossil fuels. in Journal of the Serbian Chemical Society. 2024;89(6):907-919.
doi:10.2298/JSC240126048V .

Vukićević, Emilija, Isailović, Jelena, Gajica, Gordana, Antić, Vesna, Jovančićević, Branimir, "Biochar from agricultural biomass: Green material as an ecological alternative to solid fossil fuels" in Journal of the Serbian Chemical Society, 89, no. 6 (2024):907-919,
https://doi.org/10.2298/JSC240126048V . .

TY  - JOUR
AU  - Matošević, Ana
AU  - Bartolić, Marija
AU  - Maraković, Nikola
AU  - Zandona, Antonio
AU  - Petrić, Rajo
AU  - Opsenica, Dejan
AU  - Bosak, Anita
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6617
AB  - Alzheimer’s disease is age-related multifactorial neurodegenerative disease manifested by gradual loss of memory, cognitive decline and changes in personality. Due to rapid and continuous growth of its prevalence, the treatment of Alzheimer’s disease calls for development of new and efficacies drugs, especially those that could be able to simultaneously act on more than one of possible targets of action. Aminoquinolines have proven to be a highly promising structural scaffold in the design of such a drug as cholinesterases and β-secretase 1 inhibitors. In this study, we synthesised twenty-two new 4-aminoquinolines with different halogen atom and its position in the terminal N-benzyl group or with a trifluoromethyl or a chlorine as C(7)-substituents on the quinoline moiety. All compounds were evaluated as multi-target-directedligands by determining their inhibition potency towards human acetylcholinesterase, butyrylcholinesterase and β-secretase 1. All of the tested derivatives were very potent inhibitors of human acetylcholinesterase and butyrylcholinesterase with inhibition constants (Ki) in the nM to low μM range. Most were estimated to be able to cross the blood–brain barrier by passive transport and were nontoxic toward cells that represented the main models of individual organs.
PB  - Elsevier
T2  - Bioorganic & Medicinal Chemistry Letters
T1  - Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity
VL  - 112
SP  - 129928
DO  - 10.1016/j.bmcl.2024.129928
ER  - 

@article{
author = "Matošević, Ana and Bartolić, Marija and Maraković, Nikola and Zandona, Antonio and Petrić, Rajo and Opsenica, Dejan and Bosak, Anita",
year = "2024",
abstract = "Alzheimer’s disease is age-related multifactorial neurodegenerative disease manifested by gradual loss of memory, cognitive decline and changes in personality. Due to rapid and continuous growth of its prevalence, the treatment of Alzheimer’s disease calls for development of new and efficacies drugs, especially those that could be able to simultaneously act on more than one of possible targets of action. Aminoquinolines have proven to be a highly promising structural scaffold in the design of such a drug as cholinesterases and β-secretase 1 inhibitors. In this study, we synthesised twenty-two new 4-aminoquinolines with different halogen atom and its position in the terminal N-benzyl group or with a trifluoromethyl or a chlorine as C(7)-substituents on the quinoline moiety. All compounds were evaluated as multi-target-directedligands by determining their inhibition potency towards human acetylcholinesterase, butyrylcholinesterase and β-secretase 1. All of the tested derivatives were very potent inhibitors of human acetylcholinesterase and butyrylcholinesterase with inhibition constants (Ki) in the nM to low μM range. Most were estimated to be able to cross the blood–brain barrier by passive transport and were nontoxic toward cells that represented the main models of individual organs.",
publisher = "Elsevier",
journal = "Bioorganic & Medicinal Chemistry Letters",
title = "Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity",
volume = "112",
pages = "129928",
doi = "10.1016/j.bmcl.2024.129928"
}

Matošević, A., Bartolić, M., Maraković, N., Zandona, A., Petrić, R., Opsenica, D.,& Bosak, A.. (2024). Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity. in Bioorganic & Medicinal Chemistry Letters
Elsevier., 112, 129928.
https://doi.org/10.1016/j.bmcl.2024.129928

Matošević A, Bartolić M, Maraković N, Zandona A, Petrić R, Opsenica D, Bosak A. Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity. in Bioorganic & Medicinal Chemistry Letters. 2024;112:129928.
doi:10.1016/j.bmcl.2024.129928 .

Matošević, Ana, Bartolić, Marija, Maraković, Nikola, Zandona, Antonio, Petrić, Rajo, Opsenica, Dejan, Bosak, Anita, "Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity" in Bioorganic & Medicinal Chemistry Letters, 112 (2024):129928,
https://doi.org/10.1016/j.bmcl.2024.129928 . .

TY  - DATA
AU  - Matošević, Ana
AU  - Bartolić, Marija
AU  - Maraković, Nikola
AU  - Zandona, Antonio
AU  - Petrić, Rajo
AU  - Opsenica, Dejan
AU  - Bosak, Anita
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6618
AB  - Alzheimer’s disease is age-related multifactorial neurodegenerative disease manifested by gradual loss of memory, cognitive decline and changes in personality. Due to rapid and continuous growth of its prevalence, the treatment of Alzheimer’s disease calls for development of new and efficacies drugs, especially those that could be able to simultaneously act on more than one of possible targets of action. Aminoquinolines have proven to be a highly promising structural scaffold in the design of such a drug as cholinesterases and β-secretase 1 inhibitors. In this study, we synthesised twenty-two new 4-aminoquinolines with different halogen atom and its position in the terminal N-benzyl group or with a trifluoromethyl or a chlorine as C(7)-substituents on the quinoline moiety. All compounds were evaluated as multi-target-directedligands by determining their inhibition potency towards human acetylcholinesterase, butyrylcholinesterase and β-secretase 1. All of the tested derivatives were very potent inhibitors of human acetylcholinesterase and butyrylcholinesterase with inhibition constants (Ki) in the nM to low μM range. Most were estimated to be able to cross the blood–brain barrier by passive transport and were nontoxic toward cells that represented the main models of individual organs.
PB  - Elsevier
T2  - Bioorganic & Medicinal Chemistry Letters
T1  - Supplementary material for the article: A. Matošević, M. Bartolić, N. Maraković, A. Zandona, R. Petrić, D. Opsenica, A. Bosak; Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity. Bioorganic & Medicinal Chemistry Letters 112 (2024) 129928.
VL  - 112
SP  - 129928
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6618
ER  - 

@misc{
author = "Matošević, Ana and Bartolić, Marija and Maraković, Nikola and Zandona, Antonio and Petrić, Rajo and Opsenica, Dejan and Bosak, Anita",
year = "2024",
abstract = "Alzheimer’s disease is age-related multifactorial neurodegenerative disease manifested by gradual loss of memory, cognitive decline and changes in personality. Due to rapid and continuous growth of its prevalence, the treatment of Alzheimer’s disease calls for development of new and efficacies drugs, especially those that could be able to simultaneously act on more than one of possible targets of action. Aminoquinolines have proven to be a highly promising structural scaffold in the design of such a drug as cholinesterases and β-secretase 1 inhibitors. In this study, we synthesised twenty-two new 4-aminoquinolines with different halogen atom and its position in the terminal N-benzyl group or with a trifluoromethyl or a chlorine as C(7)-substituents on the quinoline moiety. All compounds were evaluated as multi-target-directedligands by determining their inhibition potency towards human acetylcholinesterase, butyrylcholinesterase and β-secretase 1. All of the tested derivatives were very potent inhibitors of human acetylcholinesterase and butyrylcholinesterase with inhibition constants (Ki) in the nM to low μM range. Most were estimated to be able to cross the blood–brain barrier by passive transport and were nontoxic toward cells that represented the main models of individual organs.",
publisher = "Elsevier",
journal = "Bioorganic & Medicinal Chemistry Letters",
title = "Supplementary material for the article: A. Matošević, M. Bartolić, N. Maraković, A. Zandona, R. Petrić, D. Opsenica, A. Bosak; Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity. Bioorganic & Medicinal Chemistry Letters 112 (2024) 129928.",
volume = "112",
pages = "129928",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6618"
}

Matošević, A., Bartolić, M., Maraković, N., Zandona, A., Petrić, R., Opsenica, D.,& Bosak, A.. (2024). Supplementary material for the article: A. Matošević, M. Bartolić, N. Maraković, A. Zandona, R. Petrić, D. Opsenica, A. Bosak; Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity. Bioorganic & Medicinal Chemistry Letters 112 (2024) 129928.. in Bioorganic & Medicinal Chemistry Letters
Elsevier., 112, 129928.
https://hdl.handle.net/21.15107/rcub_cherry_6618

Matošević A, Bartolić M, Maraković N, Zandona A, Petrić R, Opsenica D, Bosak A. Supplementary material for the article: A. Matošević, M. Bartolić, N. Maraković, A. Zandona, R. Petrić, D. Opsenica, A. Bosak; Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity. Bioorganic & Medicinal Chemistry Letters 112 (2024) 129928.. in Bioorganic & Medicinal Chemistry Letters. 2024;112:129928.
https://hdl.handle.net/21.15107/rcub_cherry_6618 .

Matošević, Ana, Bartolić, Marija, Maraković, Nikola, Zandona, Antonio, Petrić, Rajo, Opsenica, Dejan, Bosak, Anita, "Supplementary material for the article: A. Matošević, M. Bartolić, N. Maraković, A. Zandona, R. Petrić, D. Opsenica, A. Bosak; Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity. Bioorganic & Medicinal Chemistry Letters 112 (2024) 129928." in Bioorganic & Medicinal Chemistry Letters, 112 (2024):129928,
https://hdl.handle.net/21.15107/rcub_cherry_6618 .

TY  - DATA
AU  - Savić, Slađana D.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6470
AB  - Here we see the nonthermal plasma reactor in argon atmosphere, with coaxial configuration and dielectric barrier discharge, at 35 W of discharge power.
This reactor was employed to degrade propranolol, a widely used beta-blocker.

The reactor design by University of Belgrade - Faculty of Physics

Captured by Sladjana Savic, sladjana@chem.bg.ac.rs University of Belgrade - Faculty of Chemistry
AB  - Ovde vidimo netermalni plazma reaktor u atmosferi argona, sa koaksijalnom konfiguracijom i dielektričnim barijernim pražnjenjem, pri 35 V snage pražnjenja. Ovaj reaktor je korišćen za razgradnju propranolola, široko korišćenog beta-blokatora. Dizajn reaktora Univerzitet u Beogradu - Fizički fakultet. Snimila Slađana Savić, sladjana@chem.bg.ac.rs Univerzitet u Beogradu - Hemijski fakultet
T1  - Argon plasma at 35 W in nonthermal plasma reactor - an original DBD reactor
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6470
ER  - 

@misc{
author = "Savić, Slađana D.",
year = "2024",
abstract = "Here we see the nonthermal plasma reactor in argon atmosphere, with coaxial configuration and dielectric barrier discharge, at 35 W of discharge power.
This reactor was employed to degrade propranolol, a widely used beta-blocker.

The reactor design by University of Belgrade - Faculty of Physics

Captured by Sladjana Savic, sladjana@chem.bg.ac.rs University of Belgrade - Faculty of Chemistry, Ovde vidimo netermalni plazma reaktor u atmosferi argona, sa koaksijalnom konfiguracijom i dielektričnim barijernim pražnjenjem, pri 35 V snage pražnjenja. Ovaj reaktor je korišćen za razgradnju propranolola, široko korišćenog beta-blokatora. Dizajn reaktora Univerzitet u Beogradu - Fizički fakultet. Snimila Slađana Savić, sladjana@chem.bg.ac.rs Univerzitet u Beogradu - Hemijski fakultet",
title = "Argon plasma at 35 W in nonthermal plasma reactor - an original DBD reactor",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6470"
}

Savić, S. D.. (2024). Argon plasma at 35 W in nonthermal plasma reactor - an original DBD reactor. .
https://hdl.handle.net/21.15107/rcub_cherry_6470

Savić SD. Argon plasma at 35 W in nonthermal plasma reactor - an original DBD reactor. 2024;.
https://hdl.handle.net/21.15107/rcub_cherry_6470 .

Savić, Slađana D., "Argon plasma at 35 W in nonthermal plasma reactor - an original DBD reactor" (2024),
https://hdl.handle.net/21.15107/rcub_cherry_6470 .

TY  - CONF
AU  - Margetić, Aleksandra
AU  - Ristović, Marina
AU  - Stojanović, Sanja
AU  - Pavlović, Marija
AU  - Šokarda Slavić, Marinela
AU  - Vujčić, Zoran
AU  - Dojnov, Biljana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6612
AB  - Recent technological development has focused on addressing two major global issues: environmental protection and conservation of natural resources. High levels of dye production and use have led to significant environmental concerns due to large quantities of unmanaged colored wastewater. Textile dyes, in particular, are highly reactive and problematic when released into the environment.This study investigates the use of Aspergillus fungi biomass, a byproduct of enzyme production (xylanase, cellulase, amylase, and other hydrolytic enzymes), for removing textile dyes from wastewater. The strains Aspergillus niger, Aspergillus oryzae, Aspergillus welwitschiae, and Aspergillus tubingensis were cultivated on corn meal under optimized conditions for enzyme production. The adsorption capacity of the biomass was tested on eight textile dyes: Bezaktiv Gelb, Procion reactive yellow, Reactive yellow, Golden yellow, Procion amber, Congo red, Reactive black 5, and Remazol brilliant blue.The best results were achieved with Aspergillus oryzae biomass, particularly for Reactive black 5. Optimal adsorption conditions identified by DoE were pH 4-5 and a temperature of 25°C. Within the first hour, approximately 90% of the dye (2.16 mg/g biomass) was adsorbed, and after 24 hours, over 99% was adsorbed (2.4 mg/g biomass).The findings demonstrate that post-enzyme production biomass, typically considered waste, can effectively remove reactive dyes and other xenobiotics from wastewater. This dual benefit reduces waste and mitigates water pollution, contributing significantly to environmental protection.
PB  - Izmir Institute of Technology
C3  - V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye
T1  - From Enzyme Production to Environmental Cleanup: The Dual Role of Aspergillus Biomass
SP  - PP40
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6612
ER  - 

@conference{
author = "Margetić, Aleksandra and Ristović, Marina and Stojanović, Sanja and Pavlović, Marija and Šokarda Slavić, Marinela and Vujčić, Zoran and Dojnov, Biljana",
year = "2024",
abstract = "Recent technological development has focused on addressing two major global issues: environmental protection and conservation of natural resources. High levels of dye production and use have led to significant environmental concerns due to large quantities of unmanaged colored wastewater. Textile dyes, in particular, are highly reactive and problematic when released into the environment.This study investigates the use of Aspergillus fungi biomass, a byproduct of enzyme production (xylanase, cellulase, amylase, and other hydrolytic enzymes), for removing textile dyes from wastewater. The strains Aspergillus niger, Aspergillus oryzae, Aspergillus welwitschiae, and Aspergillus tubingensis were cultivated on corn meal under optimized conditions for enzyme production. The adsorption capacity of the biomass was tested on eight textile dyes: Bezaktiv Gelb, Procion reactive yellow, Reactive yellow, Golden yellow, Procion amber, Congo red, Reactive black 5, and Remazol brilliant blue.The best results were achieved with Aspergillus oryzae biomass, particularly for Reactive black 5. Optimal adsorption conditions identified by DoE were pH 4-5 and a temperature of 25°C. Within the first hour, approximately 90% of the dye (2.16 mg/g biomass) was adsorbed, and after 24 hours, over 99% was adsorbed (2.4 mg/g biomass).The findings demonstrate that post-enzyme production biomass, typically considered waste, can effectively remove reactive dyes and other xenobiotics from wastewater. This dual benefit reduces waste and mitigates water pollution, contributing significantly to environmental protection.",
publisher = "Izmir Institute of Technology",
journal = "V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye",
title = "From Enzyme Production to Environmental Cleanup: The Dual Role of Aspergillus Biomass",
pages = "PP40",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6612"
}

Margetić, A., Ristović, M., Stojanović, S., Pavlović, M., Šokarda Slavić, M., Vujčić, Z.,& Dojnov, B.. (2024). From Enzyme Production to Environmental Cleanup: The Dual Role of Aspergillus Biomass. in V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye
Izmir Institute of Technology., PP40.
https://hdl.handle.net/21.15107/rcub_cherry_6612

Margetić A, Ristović M, Stojanović S, Pavlović M, Šokarda Slavić M, Vujčić Z, Dojnov B. From Enzyme Production to Environmental Cleanup: The Dual Role of Aspergillus Biomass. in V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye. 2024;:PP40.
https://hdl.handle.net/21.15107/rcub_cherry_6612 .

Margetić, Aleksandra, Ristović, Marina, Stojanović, Sanja, Pavlović, Marija, Šokarda Slavić, Marinela, Vujčić, Zoran, Dojnov, Biljana, "From Enzyme Production to Environmental Cleanup: The Dual Role of Aspergillus Biomass" in V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye (2024):PP40,
https://hdl.handle.net/21.15107/rcub_cherry_6612 .

TY  - CONF
AU  - Stojanović, Sanja
AU  - Ristović, Marina
AU  - Margetić, Aleksandra
AU  - Božić, Nataša
AU  - Vujčić, Zoran
AU  - Dojnov, Biljana
AU  - Vujčić, Miroslava
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6611
AB  - Recently, the exploration of agricultural by-products for biotechnological applications has gained substantial interest. This study addresses the multiple potential of corn agricultural waste, focusing on its dual utility: cellulase production and enhanced polyphenols extraction.Aspergillus welwitschiae FAW1 and Aspergillus tubingensis FAT36 strains, isolated from the environment, has proven to be good producers of the cellulase enzyme complex and at the same time non-toxigenic and safe for use in food production. Due to the fact that most of the fungal enzymes are inducible, the substrates used in this solid-state fermentation were agro-waste materials richin cellulose and hemicellulose (corn silk and corn cob). The cellulase complex was produced by growing fungal strains at 28℃for 96 h.Through enzyme assisted extraction, the release of polyphenols from corn silk was enhanced. The obtained extracts, whether we used FAW1 or FAT36 strain`s cellulase enzyme complex showed an increase in total phenolic content, ranging from 876 mg/mL to 3050 mg/mL and 2944 mg/mL, respectively, which was determined by the Folin Ciocalteu method. Increasing the amount of extractedpolyphenols led to the two to three times higher antioxidant activity of the extracts, according to ABTS and FRAP methods.This enzymatic approach offers a sustainable and eco-friendly alternative to conventional extraction methods, mitigating environmental impact while enhancing product purity. These findings not only contribute to the valorization of agricultural waste, but also emphasize the potential of corn agro-wasteas a versatile resource for bioprocessing applications, connecting enzyme production, natural product extraction and added value products obtaining.
PB  - Izmir Institute of Technology
C3  - V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye
T1  - Corn agro-waste valorization: A dual approach towards cellulase production and increased polyphenol extraction
SP  - PP17
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6611
ER  - 

@conference{
author = "Stojanović, Sanja and Ristović, Marina and Margetić, Aleksandra and Božić, Nataša and Vujčić, Zoran and Dojnov, Biljana and Vujčić, Miroslava",
year = "2024",
abstract = "Recently, the exploration of agricultural by-products for biotechnological applications has gained substantial interest. This study addresses the multiple potential of corn agricultural waste, focusing on its dual utility: cellulase production and enhanced polyphenols extraction.Aspergillus welwitschiae FAW1 and Aspergillus tubingensis FAT36 strains, isolated from the environment, has proven to be good producers of the cellulase enzyme complex and at the same time non-toxigenic and safe for use in food production. Due to the fact that most of the fungal enzymes are inducible, the substrates used in this solid-state fermentation were agro-waste materials richin cellulose and hemicellulose (corn silk and corn cob). The cellulase complex was produced by growing fungal strains at 28℃for 96 h.Through enzyme assisted extraction, the release of polyphenols from corn silk was enhanced. The obtained extracts, whether we used FAW1 or FAT36 strain`s cellulase enzyme complex showed an increase in total phenolic content, ranging from 876 mg/mL to 3050 mg/mL and 2944 mg/mL, respectively, which was determined by the Folin Ciocalteu method. Increasing the amount of extractedpolyphenols led to the two to three times higher antioxidant activity of the extracts, according to ABTS and FRAP methods.This enzymatic approach offers a sustainable and eco-friendly alternative to conventional extraction methods, mitigating environmental impact while enhancing product purity. These findings not only contribute to the valorization of agricultural waste, but also emphasize the potential of corn agro-wasteas a versatile resource for bioprocessing applications, connecting enzyme production, natural product extraction and added value products obtaining.",
publisher = "Izmir Institute of Technology",
journal = "V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye",
title = "Corn agro-waste valorization: A dual approach towards cellulase production and increased polyphenol extraction",
pages = "PP17",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6611"
}

Stojanović, S., Ristović, M., Margetić, A., Božić, N., Vujčić, Z., Dojnov, B.,& Vujčić, M.. (2024). Corn agro-waste valorization: A dual approach towards cellulase production and increased polyphenol extraction. in V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye
Izmir Institute of Technology., PP17.
https://hdl.handle.net/21.15107/rcub_cherry_6611

Stojanović S, Ristović M, Margetić A, Božić N, Vujčić Z, Dojnov B, Vujčić M. Corn agro-waste valorization: A dual approach towards cellulase production and increased polyphenol extraction. in V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye. 2024;:PP17.
https://hdl.handle.net/21.15107/rcub_cherry_6611 .

Stojanović, Sanja, Ristović, Marina, Margetić, Aleksandra, Božić, Nataša, Vujčić, Zoran, Dojnov, Biljana, Vujčić, Miroslava, "Corn agro-waste valorization: A dual approach towards cellulase production and increased polyphenol extraction" in V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye (2024):PP17,
https://hdl.handle.net/21.15107/rcub_cherry_6611 .

TY  - JOUR
AU  - Petrović, Tamara
AU  - Gligorijević, Nevenka
AU  - Medaković, Vesna
AU  - Veljković, Dušan
AU  - Aranđelović, Sandra
AU  - Grgurić-Šipka, Sanja
AU  - Poljarević, Jelena
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6608
AB  - Three oxorhenium(V) complexes [ReOLCl2(PPh3)] (C1–C3) were synthesized
 in the reaction of 2,3-pyridinedicarboxylic acid (HL1), 2,5-pyridinedicarboxylic
 acid (HL2), and 2,6-pyridinedicarboxylic acid (HL3) with [ReOCl3(PPh3)2].
 Chemical structures of synthesized compounds were confirmed using standard
 analytical techniques. The most stable geometry of complexes was proposed
 using density functional theory calculations. The antiproliferative activity of
 the synthesized complexes was evaluated in a panel of human tumor cell lines
 (A549, PANC-1, OVCAR-3, and MDA-MB-231) and in one nontumor cell line
 (MRC-5), in comparison with the activity of cisplatin as a reference drug. The
 complex C3 exhibited the highest antiproliferative potential in PANC-1 cells,
 with IC50 48.73 ± 0.31 μM. Our previous research of oxorhenium(V) com
plexes suggested the involvement of drug-efflux transporter P-glycoprotein
 (Pgp) in the detoxification of rhenium complexes in pancreatic adenocarci
noma cells. In the present study, the effect of verapamil hydrochloride, the spe
cific pharmacological blocker of Pgp, was tested in combination with novel
 rhenium complexes C1–C3 or cisplatin (CDDP), in PANC-1 cells. The verapa
mil enhanced the antiproliferative activity of complex C3, indicating again the
 role of Pgp in detoxification of oxorhenium(V) complexes in highly invasive
 and resistant PANC-1 cells.
PB  - Wiley
T2  - Applied Organometallic Chemistry
T1  - Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study
VL  - 38
SP  - e7623
DO  - 10.1002/aoc.7623
ER  - 

@article{
author = "Petrović, Tamara and Gligorijević, Nevenka and Medaković, Vesna and Veljković, Dušan and Aranđelović, Sandra and Grgurić-Šipka, Sanja and Poljarević, Jelena",
year = "2024",
abstract = "Three oxorhenium(V) complexes [ReOLCl2(PPh3)] (C1–C3) were synthesized
 in the reaction of 2,3-pyridinedicarboxylic acid (HL1), 2,5-pyridinedicarboxylic
 acid (HL2), and 2,6-pyridinedicarboxylic acid (HL3) with [ReOCl3(PPh3)2].
 Chemical structures of synthesized compounds were confirmed using standard
 analytical techniques. The most stable geometry of complexes was proposed
 using density functional theory calculations. The antiproliferative activity of
 the synthesized complexes was evaluated in a panel of human tumor cell lines
 (A549, PANC-1, OVCAR-3, and MDA-MB-231) and in one nontumor cell line
 (MRC-5), in comparison with the activity of cisplatin as a reference drug. The
 complex C3 exhibited the highest antiproliferative potential in PANC-1 cells,
 with IC50 48.73 ± 0.31 μM. Our previous research of oxorhenium(V) com
plexes suggested the involvement of drug-efflux transporter P-glycoprotein
 (Pgp) in the detoxification of rhenium complexes in pancreatic adenocarci
noma cells. In the present study, the effect of verapamil hydrochloride, the spe
cific pharmacological blocker of Pgp, was tested in combination with novel
 rhenium complexes C1–C3 or cisplatin (CDDP), in PANC-1 cells. The verapa
mil enhanced the antiproliferative activity of complex C3, indicating again the
 role of Pgp in detoxification of oxorhenium(V) complexes in highly invasive
 and resistant PANC-1 cells.",
publisher = "Wiley",
journal = "Applied Organometallic Chemistry",
title = "Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study",
volume = "38",
pages = "e7623",
doi = "10.1002/aoc.7623"
}

Petrović, T., Gligorijević, N., Medaković, V., Veljković, D., Aranđelović, S., Grgurić-Šipka, S.,& Poljarević, J.. (2024). Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study. in Applied Organometallic Chemistry
Wiley., 38, e7623.
https://doi.org/10.1002/aoc.7623

Petrović T, Gligorijević N, Medaković V, Veljković D, Aranđelović S, Grgurić-Šipka S, Poljarević J. Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study. in Applied Organometallic Chemistry. 2024;38:e7623.
doi:10.1002/aoc.7623 .

Petrović, Tamara, Gligorijević, Nevenka, Medaković, Vesna, Veljković, Dušan, Aranđelović, Sandra, Grgurić-Šipka, Sanja, Poljarević, Jelena, "Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study" in Applied Organometallic Chemistry, 38 (2024):e7623,
https://doi.org/10.1002/aoc.7623 . .

TY  - JOUR
AU  - Petrović, Tamara
AU  - Gligorijević, Nevenka
AU  - Medaković, Vesna
AU  - Veljković, Dušan
AU  - Aranđelović, Sandra
AU  - Grgurić-Šipka, Sanja
AU  - Poljarević, Jelena
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6609
AB  - Three oxorhenium(V) complexes [ReOLCl2(PPh3)] (C1–C3) were synthesized in the reaction of 2,3-pyridinedicarboxylic acid (HL1), 2,5-pyridinedicarboxylic acid (HL2), and 2,6-pyridinedicarboxylic acid (HL3) with [ReOCl3(PPh3)2]. Chemical structures of synthesized compounds were confirmed using standard analytical techniques. The most stable geometry of complexes was proposed using density functional theory calculations. The antiproliferative activity of the synthesized complexes was evaluated in a panel of human tumor cell lines (A549, PANC-1, OVCAR-3, and MDA-MB-231) and in one nontumor cell line (MRC-5), in comparison with the activity of cisplatin as a reference drug. The complex C3 exhibited the highest antiproliferative potential in PANC-1 cells, with IC50 48.73 ± 0.31 μM. Our previous research of oxorhenium(V) complexes suggested the involvement of drug-efflux transporter P-glycoprotein (Pgp) in the detoxification of rhenium complexes in pancreatic adenocarcinoma cells. In the present study, the effect of verapamil hydrochloride, the specific pharmacological blocker of Pgp, was tested in combination with novel rhenium complexes C1–C3 or cisplatin (CDDP), in PANC-1 cells. The verapamil enhanced the antiproliferative activity of complex C3, indicating again the role of Pgp in detoxification of oxorhenium(V) complexes in highly invasive and resistant PANC-1 cells.
PB  - Wiley
T2  - Applied Organometallic Chemistry
T1  - Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study
VL  - 38
SP  - e7623
DO  - 10.1002/aoc.7623
ER  - 

@article{
author = "Petrović, Tamara and Gligorijević, Nevenka and Medaković, Vesna and Veljković, Dušan and Aranđelović, Sandra and Grgurić-Šipka, Sanja and Poljarević, Jelena",
year = "2024",
abstract = "Three oxorhenium(V) complexes [ReOLCl2(PPh3)] (C1–C3) were synthesized in the reaction of 2,3-pyridinedicarboxylic acid (HL1), 2,5-pyridinedicarboxylic acid (HL2), and 2,6-pyridinedicarboxylic acid (HL3) with [ReOCl3(PPh3)2]. Chemical structures of synthesized compounds were confirmed using standard analytical techniques. The most stable geometry of complexes was proposed using density functional theory calculations. The antiproliferative activity of the synthesized complexes was evaluated in a panel of human tumor cell lines (A549, PANC-1, OVCAR-3, and MDA-MB-231) and in one nontumor cell line (MRC-5), in comparison with the activity of cisplatin as a reference drug. The complex C3 exhibited the highest antiproliferative potential in PANC-1 cells, with IC50 48.73 ± 0.31 μM. Our previous research of oxorhenium(V) complexes suggested the involvement of drug-efflux transporter P-glycoprotein (Pgp) in the detoxification of rhenium complexes in pancreatic adenocarcinoma cells. In the present study, the effect of verapamil hydrochloride, the specific pharmacological blocker of Pgp, was tested in combination with novel rhenium complexes C1–C3 or cisplatin (CDDP), in PANC-1 cells. The verapamil enhanced the antiproliferative activity of complex C3, indicating again the role of Pgp in detoxification of oxorhenium(V) complexes in highly invasive and resistant PANC-1 cells.",
publisher = "Wiley",
journal = "Applied Organometallic Chemistry",
title = "Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study",
volume = "38",
pages = "e7623",
doi = "10.1002/aoc.7623"
}

Petrović, T., Gligorijević, N., Medaković, V., Veljković, D., Aranđelović, S., Grgurić-Šipka, S.,& Poljarević, J.. (2024). Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study. in Applied Organometallic Chemistry
Wiley., 38, e7623.
https://doi.org/10.1002/aoc.7623

Petrović T, Gligorijević N, Medaković V, Veljković D, Aranđelović S, Grgurić-Šipka S, Poljarević J. Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study. in Applied Organometallic Chemistry. 2024;38:e7623.
doi:10.1002/aoc.7623 .

Petrović, Tamara, Gligorijević, Nevenka, Medaković, Vesna, Veljković, Dušan, Aranđelović, Sandra, Grgurić-Šipka, Sanja, Poljarević, Jelena, "Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study" in Applied Organometallic Chemistry, 38 (2024):e7623,
https://doi.org/10.1002/aoc.7623 . .

TY  - JOUR
AU  - Jovanović, Vesna B.
AU  - Nikolić, Milan
AU  - Stojanović, Srđan Đ.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6607
AB  - In this in silico study, it was investigated whether phycobilins
(phycocyanobilin, phycoerythrobilin and phycourobilin) could be inhibitors of
the activity of the main proteins of the SARS-CoV-2 virus. All chromophores
exhibited a binding energy value of ≥–37 kJ mol-1 for PLpro-WT, PLpro-
-C111S, helicase-ANP binding site, Nsp3-macrodomain, Nsp3-MES site and
Nsp10/14-N7-Mtase. Phycocyanobilin showed the highest binding energy of
–44.77 kJ mol-1 against the target protein PLpro-C111S. It was found that,
apart from the hydrogen bonds and hydrophobic interactions, phycobilins also
form electrostatic interactions with the SARS-CoV-2 proteins. The network of
non-covalent interactions was found to be important for the stability of the
examined virus proteins. All phycobilins have good pharmacokinetic and drug-
-likeness properties. This study’s results suggest that the screened phycobilins
could serve as promising drugs for the treatment of COVID-19 with further
rigorous validation studies.
PB  - Belgrade : Serbian Chemical Society
T2  - Jornal of Serbian Chemical Society
T1  - In silico studies of phycobilins as potential candidates for inhibitors of viral proteins associated with COVID-19
VL  - 89
IS  - 7-8
SP  - 997
EP  - 1009
DO  - 10.2298/JSC240326052J
ER  - 

@article{
author = "Jovanović, Vesna B. and Nikolić, Milan and Stojanović, Srđan Đ.",
year = "2024",
abstract = "In this in silico study, it was investigated whether phycobilins
(phycocyanobilin, phycoerythrobilin and phycourobilin) could be inhibitors of
the activity of the main proteins of the SARS-CoV-2 virus. All chromophores
exhibited a binding energy value of ≥–37 kJ mol-1 for PLpro-WT, PLpro-
-C111S, helicase-ANP binding site, Nsp3-macrodomain, Nsp3-MES site and
Nsp10/14-N7-Mtase. Phycocyanobilin showed the highest binding energy of
–44.77 kJ mol-1 against the target protein PLpro-C111S. It was found that,
apart from the hydrogen bonds and hydrophobic interactions, phycobilins also
form electrostatic interactions with the SARS-CoV-2 proteins. The network of
non-covalent interactions was found to be important for the stability of the
examined virus proteins. All phycobilins have good pharmacokinetic and drug-
-likeness properties. This study’s results suggest that the screened phycobilins
could serve as promising drugs for the treatment of COVID-19 with further
rigorous validation studies.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Jornal of Serbian Chemical Society",
title = "In silico studies of phycobilins as potential candidates for inhibitors of viral proteins associated with COVID-19",
volume = "89",
number = "7-8",
pages = "997-1009",
doi = "10.2298/JSC240326052J"
}

Jovanović, V. B., Nikolić, M.,& Stojanović, S. Đ.. (2024). In silico studies of phycobilins as potential candidates for inhibitors of viral proteins associated with COVID-19. in Jornal of Serbian Chemical Society
Belgrade : Serbian Chemical Society., 89(7-8), 997-1009.
https://doi.org/10.2298/JSC240326052J

Jovanović VB, Nikolić M, Stojanović SĐ. In silico studies of phycobilins as potential candidates for inhibitors of viral proteins associated with COVID-19. in Jornal of Serbian Chemical Society. 2024;89(7-8):997-1009.
doi:10.2298/JSC240326052J .

Jovanović, Vesna B., Nikolić, Milan, Stojanović, Srđan Đ., "In silico studies of phycobilins as potential candidates for inhibitors of viral proteins associated with COVID-19" in Jornal of Serbian Chemical Society, 89, no. 7-8 (2024):997-1009,
https://doi.org/10.2298/JSC240326052J . .

TY  - JOUR
AU  - Ćurčić, Vladimir
AU  - Olszewski, Mateusz
AU  - Maciejewska, Natalia
AU  - Višnjevac, Aleksandar
AU  - Srdić-Rajić, Tatjana
AU  - Dobričić, Vladimir
AU  - García-Sosa, Alfonso T.
AU  - Kokanov, Sanja B.
AU  - Araškov, Jovana
AU  - Silvestri, Romano
AU  - Schüle, Roland
AU  - Jung, Manfred
AU  - Nikolić, Milan
AU  - Filipović, Nenad R.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6392
AB  - Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.
PB  - John Wiley and Sons Inc
T2  - Archiv der Pharmazie
T2  - Archiv der Pharmazie
T1  - Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
VL  - 357
IS  - 2
SP  - e2300426
DO  - 10.1002/ardp.202300426
ER  - 

@article{
author = "Ćurčić, Vladimir and Olszewski, Mateusz and Maciejewska, Natalia and Višnjevac, Aleksandar and Srdić-Rajić, Tatjana and Dobričić, Vladimir and García-Sosa, Alfonso T. and Kokanov, Sanja B. and Araškov, Jovana and Silvestri, Romano and Schüle, Roland and Jung, Manfred and Nikolić, Milan and Filipović, Nenad R.",
year = "2024",
abstract = "Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.",
publisher = "John Wiley and Sons Inc",
journal = "Archiv der Pharmazie, Archiv der Pharmazie",
title = "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition",
volume = "357",
number = "2",
pages = "e2300426",
doi = "10.1002/ardp.202300426"
}

Ćurčić, V., Olszewski, M., Maciejewska, N., Višnjevac, A., Srdić-Rajić, T., Dobričić, V., García-Sosa, A. T., Kokanov, S. B., Araškov, J., Silvestri, R., Schüle, R., Jung, M., Nikolić, M.,& Filipović, N. R.. (2024). Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie
John Wiley and Sons Inc., 357(2), e2300426.
https://doi.org/10.1002/ardp.202300426

Ćurčić V, Olszewski M, Maciejewska N, Višnjevac A, Srdić-Rajić T, Dobričić V, García-Sosa AT, Kokanov SB, Araškov J, Silvestri R, Schüle R, Jung M, Nikolić M, Filipović NR. Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie. 2024;357(2):e2300426.
doi:10.1002/ardp.202300426 .

Ćurčić, Vladimir, Olszewski, Mateusz, Maciejewska, Natalia, Višnjevac, Aleksandar, Srdić-Rajić, Tatjana, Dobričić, Vladimir, García-Sosa, Alfonso T., Kokanov, Sanja B., Araškov, Jovana, Silvestri, Romano, Schüle, Roland, Jung, Manfred, Nikolić, Milan, Filipović, Nenad R., "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition" in Archiv der Pharmazie, 357, no. 2 (2024):e2300426,
https://doi.org/10.1002/ardp.202300426 . .

TY  - JOUR
AU  - Uzelac, Tamara N.
AU  - Smiljanić, Katarina
AU  - Takić, Marija
AU  - Sarac, Ivana
AU  - Petovic-Oggiano, Gordana
AU  - Nikolić, Milan
AU  - Jovanović, Vesna B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6429
AB  - The binding of ubiquitous serum ligands (free fatty acids) to human serum albumin (HSA)
or its glycation can affect thiol group reactivity, thus influencing its antioxidant activity. The effects
of stearic acid (SA) and glucose binding on HSA structural changes and thiol group content and
reactivity were monitored by fluoroscopy and the Ellman method during a 14-day incubation in
molar ratios to HSA that mimic pathophysiological conditions. Upon incubation with 5 mM glucose,
HSA glycation was the same as HSA without it, in three different HSA:SA molar ratios (HSA:SA-
1:1-2-4). The protective effect of SA on the antioxidant property of HSA under different glucose
regimes (5-10-20 mM) was significantly affected by molar ratios of HSA:SA. Thiol reactivity was fully
restored with 5–20 mM glucose at a 1:1 HSA:SA ratio, while the highest thiol content recovery was in
pathological glucose regimes at a 1:1 HSA:SA ratio. The SA affinity for HSA increased significantly
(1.5- and 1.3-fold, p < 0.01) with 5 and 10 mM glucose compared to the control. These results deepen
the knowledge about the possible regulation of the antioxidant role of HSA in diabetes and other
pathophysiological conditions and enable the design of future HSA-drug studies which, in turn, is
important for clinicians when designing information-based treatments.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding
VL  - 5
SP  - 2335
DO  - 10.3390/ijms25042335
ER  - 

@article{
author = "Uzelac, Tamara N. and Smiljanić, Katarina and Takić, Marija and Sarac, Ivana and Petovic-Oggiano, Gordana and Nikolić, Milan and Jovanović, Vesna B.",
year = "2024",
abstract = "The binding of ubiquitous serum ligands (free fatty acids) to human serum albumin (HSA)
or its glycation can affect thiol group reactivity, thus influencing its antioxidant activity. The effects
of stearic acid (SA) and glucose binding on HSA structural changes and thiol group content and
reactivity were monitored by fluoroscopy and the Ellman method during a 14-day incubation in
molar ratios to HSA that mimic pathophysiological conditions. Upon incubation with 5 mM glucose,
HSA glycation was the same as HSA without it, in three different HSA:SA molar ratios (HSA:SA-
1:1-2-4). The protective effect of SA on the antioxidant property of HSA under different glucose
regimes (5-10-20 mM) was significantly affected by molar ratios of HSA:SA. Thiol reactivity was fully
restored with 5–20 mM glucose at a 1:1 HSA:SA ratio, while the highest thiol content recovery was in
pathological glucose regimes at a 1:1 HSA:SA ratio. The SA affinity for HSA increased significantly
(1.5- and 1.3-fold, p < 0.01) with 5 and 10 mM glucose compared to the control. These results deepen
the knowledge about the possible regulation of the antioxidant role of HSA in diabetes and other
pathophysiological conditions and enable the design of future HSA-drug studies which, in turn, is
important for clinicians when designing information-based treatments.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding",
volume = "5",
pages = "2335",
doi = "10.3390/ijms25042335"
}

Uzelac, T. N., Smiljanić, K., Takić, M., Sarac, I., Petovic-Oggiano, G., Nikolić, M.,& Jovanović, V. B.. (2024). The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding. in International Journal of Molecular Sciences
MDPI., 5, 2335.
https://doi.org/10.3390/ijms25042335

Uzelac TN, Smiljanić K, Takić M, Sarac I, Petovic-Oggiano G, Nikolić M, Jovanović VB. The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding. in International Journal of Molecular Sciences. 2024;5:2335.
doi:10.3390/ijms25042335 .

Uzelac, Tamara N., Smiljanić, Katarina, Takić, Marija, Sarac, Ivana, Petovic-Oggiano, Gordana, Nikolić, Milan, Jovanović, Vesna B., "The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding" in International Journal of Molecular Sciences, 5 (2024):2335,
https://doi.org/10.3390/ijms25042335 . .

TY  - JOUR
AU  - Gligorijević, Nikola
AU  - Jovanović, Zorana
AU  - Cvijetić, Ilija
AU  - Šunderić, Miloš
AU  - Veličković, Luka
AU  - Katrlík, Jaroslav
AU  - Holazová, Alena
AU  - Nikolić, Milan
AU  - Minić, Simeon
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6524
AB  - Blue C-phycocyanin (C-PC), the major Spirulina protein with innumerable health-promoting
benefits, is an attractive colourant and food supplement. A crucial obstacle to its more extensive
use is its relatively low stability. This study aimed to screen various food-derived ligands for their
ability to bind and stabilise C-PC, utilising spectroscopic techniques and molecular docking. Among twelve examined ligands, the protein fluorescence quenching revealed that only quercetin, coenzyme Q10 and resveratrol had a moderate affinity to C-PC (Ka of 2.2 to 3.7 × 105 M–1). Docking revealed these three ligands bind more strongly to the C-PC hexamer than the trimer, with the binding sites located at the interface of two (αβ)3 trimers. UV/VIS absorption spectroscopy demonstrated the changes in the C-PC absorption spectra in a complex with quercetin and resveratrol compared to the spectra of free protein and ligands. Selected ligands did not affect the secondary structure content, but they induced changes in the tertiary protein structure in the CD study. A fluorescence-based thermal stability assay demonstrated quercetin and coenzyme Q10 increased the C-PC melting point by nearly 5 ◦C. Our study identified food-derived ligands that interact with C-PC and improve its thermal stability, indicating their potential as stabilising agents for C-PC in the food industry.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina
DO  - 10.3390/ijms25010229
ER  - 

@article{
author = "Gligorijević, Nikola and Jovanović, Zorana and Cvijetić, Ilija and Šunderić, Miloš and Veličković, Luka and Katrlík, Jaroslav and Holazová, Alena and Nikolić, Milan and Minić, Simeon",
year = "2024",
abstract = "Blue C-phycocyanin (C-PC), the major Spirulina protein with innumerable health-promoting
benefits, is an attractive colourant and food supplement. A crucial obstacle to its more extensive
use is its relatively low stability. This study aimed to screen various food-derived ligands for their
ability to bind and stabilise C-PC, utilising spectroscopic techniques and molecular docking. Among twelve examined ligands, the protein fluorescence quenching revealed that only quercetin, coenzyme Q10 and resveratrol had a moderate affinity to C-PC (Ka of 2.2 to 3.7 × 105 M–1). Docking revealed these three ligands bind more strongly to the C-PC hexamer than the trimer, with the binding sites located at the interface of two (αβ)3 trimers. UV/VIS absorption spectroscopy demonstrated the changes in the C-PC absorption spectra in a complex with quercetin and resveratrol compared to the spectra of free protein and ligands. Selected ligands did not affect the secondary structure content, but they induced changes in the tertiary protein structure in the CD study. A fluorescence-based thermal stability assay demonstrated quercetin and coenzyme Q10 increased the C-PC melting point by nearly 5 ◦C. Our study identified food-derived ligands that interact with C-PC and improve its thermal stability, indicating their potential as stabilising agents for C-PC in the food industry.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina",
doi = "10.3390/ijms25010229"
}

Gligorijević, N., Jovanović, Z., Cvijetić, I., Šunderić, M., Veličković, L., Katrlík, J., Holazová, A., Nikolić, M.,& Minić, S.. (2024). Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina. in International Journal of Molecular Sciences
MDPI..
https://doi.org/10.3390/ijms25010229

Gligorijević N, Jovanović Z, Cvijetić I, Šunderić M, Veličković L, Katrlík J, Holazová A, Nikolić M, Minić S. Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina. in International Journal of Molecular Sciences. 2024;.
doi:10.3390/ijms25010229 .

Gligorijević, Nikola, Jovanović, Zorana, Cvijetić, Ilija, Šunderić, Miloš, Veličković, Luka, Katrlík, Jaroslav, Holazová, Alena, Nikolić, Milan, Minić, Simeon, "Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina" in International Journal of Molecular Sciences (2024),
https://doi.org/10.3390/ijms25010229 . .

TY  - JOUR
AU  - Jakovljević, Danijel
AU  - Nikolić, Milan
AU  - Jovanović, Vesna B.
AU  - Vidonja Uzelac, Teodora
AU  - Nikolić-Kokić, Aleksandra
AU  - Novaković, Emilija
AU  - Miljević, Čedo
AU  - Milovanović, Maja
AU  - Blagojević, Duško
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6574
AB  - Background: Epilepsy is a chronic brain disease affecting millions of people worldwide,
but little is known about the impact of anti-seizure medications on redox homeostasis. Methods:
This study aimed to compare the effects of the long-term use of oral anti-seizure medications in
monotherapy (lamotrigine, carbamazepine, and valproate) on antioxidant enzymes: superoxide dismutase,
catalase, glutathione peroxidase, glutathione reductase, haemoglobin, and methaemoglobin
content in erythrocytes, and concentrations of total proteins and thiols, nitrites, lipid peroxides and
total glutathione in the plasma of epilepsy patients and drug-naïve patients. Results: The results
showed that lamotrigine therapy led to lower superoxide dismutase activity (p < 0.005) and lower
concentrations of total thiols (p < 0.01) and lipid peroxides (p < 0.01) compared to controls. On the
other hand, therapy with carbamazepine increased nitrite levels (p < 0.01) but reduced superoxide
dismutase activity (p < 0.005). In the valproate group, only a decrease in catalase activity was observed
(p < 0.005). Canonical discriminant analysis showed that the composition of antioxidant enzymes in
erythrocytes was different for both the lamotrigine and carbamazepine groups, while the controls
were separated from all others. Conclusions: Monotherapy with anti-seizure medications discretely
alters redox homeostasis, followed by distinct relationships between antioxidant components.
PB  - MDPI
T2  - Pharmaceuticals
T1  - Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood
VL  - 17
IS  - 1
SP  - 130
DO  - 10.3390/ph17010130
ER  - 

@article{
author = "Jakovljević, Danijel and Nikolić, Milan and Jovanović, Vesna B. and Vidonja Uzelac, Teodora and Nikolić-Kokić, Aleksandra and Novaković, Emilija and Miljević, Čedo and Milovanović, Maja and Blagojević, Duško",
year = "2024",
abstract = "Background: Epilepsy is a chronic brain disease affecting millions of people worldwide,
but little is known about the impact of anti-seizure medications on redox homeostasis. Methods:
This study aimed to compare the effects of the long-term use of oral anti-seizure medications in
monotherapy (lamotrigine, carbamazepine, and valproate) on antioxidant enzymes: superoxide dismutase,
catalase, glutathione peroxidase, glutathione reductase, haemoglobin, and methaemoglobin
content in erythrocytes, and concentrations of total proteins and thiols, nitrites, lipid peroxides and
total glutathione in the plasma of epilepsy patients and drug-naïve patients. Results: The results
showed that lamotrigine therapy led to lower superoxide dismutase activity (p < 0.005) and lower
concentrations of total thiols (p < 0.01) and lipid peroxides (p < 0.01) compared to controls. On the
other hand, therapy with carbamazepine increased nitrite levels (p < 0.01) but reduced superoxide
dismutase activity (p < 0.005). In the valproate group, only a decrease in catalase activity was observed
(p < 0.005). Canonical discriminant analysis showed that the composition of antioxidant enzymes in
erythrocytes was different for both the lamotrigine and carbamazepine groups, while the controls
were separated from all others. Conclusions: Monotherapy with anti-seizure medications discretely
alters redox homeostasis, followed by distinct relationships between antioxidant components.",
publisher = "MDPI",
journal = "Pharmaceuticals",
title = "Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood",
volume = "17",
number = "1",
pages = "130",
doi = "10.3390/ph17010130"
}

Jakovljević, D., Nikolić, M., Jovanović, V. B., Vidonja Uzelac, T., Nikolić-Kokić, A., Novaković, E., Miljević, Č., Milovanović, M.,& Blagojević, D.. (2024). Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood. in Pharmaceuticals
MDPI., 17(1), 130.
https://doi.org/10.3390/ph17010130

Jakovljević D, Nikolić M, Jovanović VB, Vidonja Uzelac T, Nikolić-Kokić A, Novaković E, Miljević Č, Milovanović M, Blagojević D. Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood. in Pharmaceuticals. 2024;17(1):130.
doi:10.3390/ph17010130 .

Jakovljević, Danijel, Nikolić, Milan, Jovanović, Vesna B., Vidonja Uzelac, Teodora, Nikolić-Kokić, Aleksandra, Novaković, Emilija, Miljević, Čedo, Milovanović, Maja, Blagojević, Duško, "Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood" in Pharmaceuticals, 17, no. 1 (2024):130,
https://doi.org/10.3390/ph17010130 . .

TY  - JOUR
AU  - Ćujić, Svetlana
AU  - Jankov, Milica
AU  - Ristivojević, Petar
AU  - Andrić, Filip
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6603
AB  - Anewmethodforefficiently selecting polypotent natural products is proposed in this study. The method involves using effect-directed HPTLC data and multiobjective optimization algorithms to extract chromatographic signals from HPTLC bioassay images. Three different multiobjective optimization methods, namely Derringer’s desirability approach, Technique for order of preference by similarity to ideal solution (TOPSIS), and Sum of ranking differences (SRD), were applied to the chromatographic signals. In combination with jackknife cross-validation, Derringer’s approach and TOPSIS demonstrated high similarity in finding the best (most polypotent), next to the best, next to the worst, and worst (least polypotent) extracts, while the SRD resulted in slightly different outcomes. Furthermore, a new method for identifying the chromatographic features that characterize the most polypotent extracts was proposed. This method is based on partial least square regression (PLS) and can be used in combination with HPTLC-chemical fingerprints to predict the desirability of new extracts. The resulting PLS models demonstrated high statistical performance with determination coefficients ranging from R 2 = 0.885 in the case of Derringer’s desirability, to 0.986 for TOPSIS. However, the PLS modeling of SRD values was not successful.
PB  - Elsevier
T2  - Journal of Chromatography A
T1  - Multiobjective optimization of effect-directed planar chromatography as a promising tool for fast selection of polypotent natural products
VL  - 1732
SP  - 465252
DO  - 10.1016/j.chroma.2024.465252
ER  - 

@article{
author = "Ćujić, Svetlana and Jankov, Milica and Ristivojević, Petar and Andrić, Filip",
year = "2024",
abstract = "Anewmethodforefficiently selecting polypotent natural products is proposed in this study. The method involves using effect-directed HPTLC data and multiobjective optimization algorithms to extract chromatographic signals from HPTLC bioassay images. Three different multiobjective optimization methods, namely Derringer’s desirability approach, Technique for order of preference by similarity to ideal solution (TOPSIS), and Sum of ranking differences (SRD), were applied to the chromatographic signals. In combination with jackknife cross-validation, Derringer’s approach and TOPSIS demonstrated high similarity in finding the best (most polypotent), next to the best, next to the worst, and worst (least polypotent) extracts, while the SRD resulted in slightly different outcomes. Furthermore, a new method for identifying the chromatographic features that characterize the most polypotent extracts was proposed. This method is based on partial least square regression (PLS) and can be used in combination with HPTLC-chemical fingerprints to predict the desirability of new extracts. The resulting PLS models demonstrated high statistical performance with determination coefficients ranging from R 2 = 0.885 in the case of Derringer’s desirability, to 0.986 for TOPSIS. However, the PLS modeling of SRD values was not successful.",
publisher = "Elsevier",
journal = "Journal of Chromatography A",
title = "Multiobjective optimization of effect-directed planar chromatography as a promising tool for fast selection of polypotent natural products",
volume = "1732",
pages = "465252",
doi = "10.1016/j.chroma.2024.465252"
}

Ćujić, S., Jankov, M., Ristivojević, P.,& Andrić, F.. (2024). Multiobjective optimization of effect-directed planar chromatography as a promising tool for fast selection of polypotent natural products. in Journal of Chromatography A
Elsevier., 1732, 465252.
https://doi.org/10.1016/j.chroma.2024.465252

Ćujić S, Jankov M, Ristivojević P, Andrić F. Multiobjective optimization of effect-directed planar chromatography as a promising tool for fast selection of polypotent natural products. in Journal of Chromatography A. 2024;1732:465252.
doi:10.1016/j.chroma.2024.465252 .

Ćujić, Svetlana, Jankov, Milica, Ristivojević, Petar, Andrić, Filip, "Multiobjective optimization of effect-directed planar chromatography as a promising tool for fast selection of polypotent natural products" in Journal of Chromatography A, 1732 (2024):465252,
https://doi.org/10.1016/j.chroma.2024.465252 . .

TY  - JOUR
AU  - Jednak Berić, Tanja
AU  - Vrvić, Miroslav
AU  - Lješević, Marija
AU  - Avdalović, Jelena
AU  - Ilić, Mila
AU  - Crnković, Dragan
AU  - Jovančićević, Branimir
AU  - Miletić, Srđan
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6604
AB  - Environmental contextMitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents.RationaleBioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies.MethodologyIn this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction.ResultsIn our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased.DiscussionThe sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.
PB  - CSIRO Publishing
T2  - Environmental Chemistry
T1  - Supplementary material for the article: T. Jednak Berić, M. M. Vrvić, M. Lješević, J. Avdalović, M. Ilić, D. Crnković, B. Jovančićević, S. Miletić; Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. Environmental Chemistry 21 (2024) EN23111. https://doi.org/10.1071/EN23111
VL  - 21
IS  - 5
SP  - EN23111
DO  - 10.1071/EN23111
ER  - 

@article{
author = "Jednak Berić, Tanja and Vrvić, Miroslav and Lješević, Marija and Avdalović, Jelena and Ilić, Mila and Crnković, Dragan and Jovančićević, Branimir and Miletić, Srđan",
year = "2024",
abstract = "Environmental contextMitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents.RationaleBioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies.MethodologyIn this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction.ResultsIn our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased.DiscussionThe sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.",
publisher = "CSIRO Publishing",
journal = "Environmental Chemistry",
title = "Supplementary material for the article: T. Jednak Berić, M. M. Vrvić, M. Lješević, J. Avdalović, M. Ilić, D. Crnković, B. Jovančićević, S. Miletić; Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. Environmental Chemistry 21 (2024) EN23111. https://doi.org/10.1071/EN23111",
volume = "21",
number = "5",
pages = "EN23111",
doi = "10.1071/EN23111"
}

Jednak Berić, T., Vrvić, M., Lješević, M., Avdalović, J., Ilić, M., Crnković, D., Jovančićević, B.,& Miletić, S.. (2024). Supplementary material for the article: T. Jednak Berić, M. M. Vrvić, M. Lješević, J. Avdalović, M. Ilić, D. Crnković, B. Jovančićević, S. Miletić; Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. Environmental Chemistry 21 (2024) EN23111. https://doi.org/10.1071/EN23111. in Environmental Chemistry
CSIRO Publishing., 21(5), EN23111.
https://doi.org/10.1071/EN23111

Jednak Berić T, Vrvić M, Lješević M, Avdalović J, Ilić M, Crnković D, Jovančićević B, Miletić S. Supplementary material for the article: T. Jednak Berić, M. M. Vrvić, M. Lješević, J. Avdalović, M. Ilić, D. Crnković, B. Jovančićević, S. Miletić; Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. Environmental Chemistry 21 (2024) EN23111. https://doi.org/10.1071/EN23111. in Environmental Chemistry. 2024;21(5):EN23111.
doi:10.1071/EN23111 .

Jednak Berić, Tanja, Vrvić, Miroslav, Lješević, Marija, Avdalović, Jelena, Ilić, Mila, Crnković, Dragan, Jovančićević, Branimir, Miletić, Srđan, "Supplementary material for the article: T. Jednak Berić, M. M. Vrvić, M. Lješević, J. Avdalović, M. Ilić, D. Crnković, B. Jovančićević, S. Miletić; Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. Environmental Chemistry 21 (2024) EN23111. https://doi.org/10.1071/EN23111" in Environmental Chemistry, 21, no. 5 (2024):EN23111,
https://doi.org/10.1071/EN23111 . .

TY  - JOUR
AU  - Jednak Berić, Tanja
AU  - Vrvić, Miroslav
AU  - Lješević, Marija
AU  - Avdalović, Jelena
AU  - Ilić, Mila
AU  - Crnković, Dragan
AU  - Jovančićević, Branimir
AU  - Miletić, Srđan
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6579
AB  - Environmental contextMitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents.RationaleBioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies.MethodologyIn this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction.ResultsIn our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased.DiscussionThe sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.
PB  - CSIRO Publishing
T2  - Environmental Chemistry
T1  - Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage
VL  - 21
IS  - 5
SP  - EN23111
DO  - 10.1071/EN23111
ER  - 

@article{
author = "Jednak Berić, Tanja and Vrvić, Miroslav and Lješević, Marija and Avdalović, Jelena and Ilić, Mila and Crnković, Dragan and Jovančićević, Branimir and Miletić, Srđan",
year = "2024",
abstract = "Environmental contextMitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents.RationaleBioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies.MethodologyIn this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction.ResultsIn our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased.DiscussionThe sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.",
publisher = "CSIRO Publishing",
journal = "Environmental Chemistry",
title = "Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage",
volume = "21",
number = "5",
pages = "EN23111",
doi = "10.1071/EN23111"
}

Jednak Berić, T., Vrvić, M., Lješević, M., Avdalović, J., Ilić, M., Crnković, D., Jovančićević, B.,& Miletić, S.. (2024). Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. in Environmental Chemistry
CSIRO Publishing., 21(5), EN23111.
https://doi.org/10.1071/EN23111

Jednak Berić T, Vrvić M, Lješević M, Avdalović J, Ilić M, Crnković D, Jovančićević B, Miletić S. Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. in Environmental Chemistry. 2024;21(5):EN23111.
doi:10.1071/EN23111 .

Jednak Berić, Tanja, Vrvić, Miroslav, Lješević, Marija, Avdalović, Jelena, Ilić, Mila, Crnković, Dragan, Jovančićević, Branimir, Miletić, Srđan, "Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage" in Environmental Chemistry, 21, no. 5 (2024):EN23111,
https://doi.org/10.1071/EN23111 . .

TY  - CONF
AU  - Kaseke, Tafadzwa
AU  - Jovanović, Vesna B.
AU  - Ćirković Veličković, Tanja
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6571
AB  - Infants are exposed to and ingest more micro-and nanoplastics (MNPs) than any other age group1; however, the effect of MNPs on the digestion of proteins in infants is not known. Therefore, the current study investigated the in vitro digestion of cow’s milk proteins in the presence of polypropylene MNPs (PP-MNPs) in simulated gastric fluids (SGF) using infant digestion model (pH=5.0; pepsin activity=268 U/mL). The simulated in vitro digestion of skimmed (<1% fat) cow’s milk proteins in infants in the presence of PP-MPs (20 mg/mL; 63–180 μm in size) was done at 37 °C for 5, 30, and 120 min. The in vitro digestion experiment was repeated with different concentrations of PP-NPs (125, 250, and 500 μg/mL) for 30 min. Another experiment was set up using adult gastrointestinal conditions (pH=3.0; pepsin activity=2000 U/mL) for comparison purposes2. The final concentration of the cow’s milk protein in the digestion mixture was 1 mg/mL. Then, proteins binding to the PP-MNPs were extracted from the soft corona and hard corona using the centrifugation method and protein profiles were analyzed using SDS-PAGE. The bands of proteins of interest were carefully excised from the gels and analysed by LC–MS/MS. Both PP-MPs and PP-NPs negatively affected the digestion of proteins in infants, and binding was observed in both the soft and hard corona. Meanwhile, no significant effects of both PP-MPs and PP-NPs on protein digestion were observed in adults. These results suggest possible interference of MNPs with the utilization of proteins in infants, which could have detrimental health effects.
PB  - University of Belgrade – Faculty of Chemistry
C3  - VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024
T1  - Polypropylene micro-and nanoplastics affects the digestion of cow's milk proteins in infants
SP  - 21
EP  - 21
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6571
ER  - 

@conference{
author = "Kaseke, Tafadzwa and Jovanović, Vesna B. and Ćirković Veličković, Tanja",
year = "2024",
abstract = "Infants are exposed to and ingest more micro-and nanoplastics (MNPs) than any other age group1; however, the effect of MNPs on the digestion of proteins in infants is not known. Therefore, the current study investigated the in vitro digestion of cow’s milk proteins in the presence of polypropylene MNPs (PP-MNPs) in simulated gastric fluids (SGF) using infant digestion model (pH=5.0; pepsin activity=268 U/mL). The simulated in vitro digestion of skimmed (<1% fat) cow’s milk proteins in infants in the presence of PP-MPs (20 mg/mL; 63–180 μm in size) was done at 37 °C for 5, 30, and 120 min. The in vitro digestion experiment was repeated with different concentrations of PP-NPs (125, 250, and 500 μg/mL) for 30 min. Another experiment was set up using adult gastrointestinal conditions (pH=3.0; pepsin activity=2000 U/mL) for comparison purposes2. The final concentration of the cow’s milk protein in the digestion mixture was 1 mg/mL. Then, proteins binding to the PP-MNPs were extracted from the soft corona and hard corona using the centrifugation method and protein profiles were analyzed using SDS-PAGE. The bands of proteins of interest were carefully excised from the gels and analysed by LC–MS/MS. Both PP-MPs and PP-NPs negatively affected the digestion of proteins in infants, and binding was observed in both the soft and hard corona. Meanwhile, no significant effects of both PP-MPs and PP-NPs on protein digestion were observed in adults. These results suggest possible interference of MNPs with the utilization of proteins in infants, which could have detrimental health effects.",
publisher = "University of Belgrade – Faculty of Chemistry",
journal = "VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024",
title = "Polypropylene micro-and nanoplastics affects the digestion of cow's milk proteins in infants",
pages = "21-21",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6571"
}

Kaseke, T., Jovanović, V. B.,& Ćirković Veličković, T.. (2024). Polypropylene micro-and nanoplastics affects the digestion of cow's milk proteins in infants. in VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024
University of Belgrade – Faculty of Chemistry., 21-21.
https://hdl.handle.net/21.15107/rcub_cherry_6571

Kaseke T, Jovanović VB, Ćirković Veličković T. Polypropylene micro-and nanoplastics affects the digestion of cow's milk proteins in infants. in VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024. 2024;:21-21.
https://hdl.handle.net/21.15107/rcub_cherry_6571 .

Kaseke, Tafadzwa, Jovanović, Vesna B., Ćirković Veličković, Tanja, "Polypropylene micro-and nanoplastics affects the digestion of cow's milk proteins in infants" in VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024 (2024):21-21,
https://hdl.handle.net/21.15107/rcub_cherry_6571 .

TY  - JOUR
AU  - Vranić, Sofija
AU  - Vujisić, Ljubodrag
AU  - Vesović, Nikola
AU  - Todosijević, Marina
AU  - Pantelić, Dejan
AU  - Pavlović, Danica
AU  - Ivanović, Stefan
AU  - Vasović, Marija
AU  - Ćurčić, Srećko
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6598
AB  - Ground beetles possess a pair of pygidial glands that produce and release secretions that play an important role in defense against predators. The morphology of these glands and the chemical composition of their products were studied in four species of the tribe Sphodrini: Calathus (Calathus) fuscipes (Goeze, 1777), C. (Neocalathus) cinctus Motschulsky, 1850, C. (N.) melanocephalus (Linnaeus, 1758) and Laemostenus (Antisphodrus) elongatus (Dejean, 1828). The morphological analyzes of the glands of the four taxa mentioned were carried out for the first time using bright-field and nonlinear microscopy. All morphological structures were precisely measured and photographed. The pygidial gland secretions of C. (C.) fuscipes and L. (A.) elongatus were analyzed for the first time using gas chromatography-mass spectrometry. A total of 30 compounds were detected from the extracts of pygidial gland secretions of the four Sphodrini species studied. The simplest chemical mixture was found in L. (A.) elongatus, while the most complex secretion was that of C. (C.) fuscipes. 1-Undecanol, which we were able to detect in all taxa examined here, and dodecyl butyrate, which was detected in the three Calathus species, have never before been detected in the secretions of ground beetles.
PB  - Elsevier
T2  - Journal of Insect Physiology
T1  - The morphology of the pygidial glands and the chemical composition of their secretions of four sphodrine ground beetle species (Carabidae: Platyninae)
VL  - 158
SP  - 104685
DO  - 10.1016/j.jinsphys.2024.104685
ER  - 

@article{
author = "Vranić, Sofija and Vujisić, Ljubodrag and Vesović, Nikola and Todosijević, Marina and Pantelić, Dejan and Pavlović, Danica and Ivanović, Stefan and Vasović, Marija and Ćurčić, Srećko",
year = "2024",
abstract = "Ground beetles possess a pair of pygidial glands that produce and release secretions that play an important role in defense against predators. The morphology of these glands and the chemical composition of their products were studied in four species of the tribe Sphodrini: Calathus (Calathus) fuscipes (Goeze, 1777), C. (Neocalathus) cinctus Motschulsky, 1850, C. (N.) melanocephalus (Linnaeus, 1758) and Laemostenus (Antisphodrus) elongatus (Dejean, 1828). The morphological analyzes of the glands of the four taxa mentioned were carried out for the first time using bright-field and nonlinear microscopy. All morphological structures were precisely measured and photographed. The pygidial gland secretions of C. (C.) fuscipes and L. (A.) elongatus were analyzed for the first time using gas chromatography-mass spectrometry. A total of 30 compounds were detected from the extracts of pygidial gland secretions of the four Sphodrini species studied. The simplest chemical mixture was found in L. (A.) elongatus, while the most complex secretion was that of C. (C.) fuscipes. 1-Undecanol, which we were able to detect in all taxa examined here, and dodecyl butyrate, which was detected in the three Calathus species, have never before been detected in the secretions of ground beetles.",
publisher = "Elsevier",
journal = "Journal of Insect Physiology",
title = "The morphology of the pygidial glands and the chemical composition of their secretions of four sphodrine ground beetle species (Carabidae: Platyninae)",
volume = "158",
pages = "104685",
doi = "10.1016/j.jinsphys.2024.104685"
}

Vranić, S., Vujisić, L., Vesović, N., Todosijević, M., Pantelić, D., Pavlović, D., Ivanović, S., Vasović, M.,& Ćurčić, S.. (2024). The morphology of the pygidial glands and the chemical composition of their secretions of four sphodrine ground beetle species (Carabidae: Platyninae). in Journal of Insect Physiology
Elsevier., 158, 104685.
https://doi.org/10.1016/j.jinsphys.2024.104685

Vranić S, Vujisić L, Vesović N, Todosijević M, Pantelić D, Pavlović D, Ivanović S, Vasović M, Ćurčić S. The morphology of the pygidial glands and the chemical composition of their secretions of four sphodrine ground beetle species (Carabidae: Platyninae). in Journal of Insect Physiology. 2024;158:104685.
doi:10.1016/j.jinsphys.2024.104685 .

Vranić, Sofija, Vujisić, Ljubodrag, Vesović, Nikola, Todosijević, Marina, Pantelić, Dejan, Pavlović, Danica, Ivanović, Stefan, Vasović, Marija, Ćurčić, Srećko, "The morphology of the pygidial glands and the chemical composition of their secretions of four sphodrine ground beetle species (Carabidae: Platyninae)" in Journal of Insect Physiology, 158 (2024):104685,
https://doi.org/10.1016/j.jinsphys.2024.104685 . .

TY  - JOUR
AU  - Mitić, Bojan
AU  - Jovanović, Vesna B.
AU  - Todosijević, Marina M.
AU  - Eckhard, Margret
AU  - Vasiljević, Ljubica
AU  - Tešević, Vele
AU  - Vujisić, Ljubodrag
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6572
AB  - Chemical substances are of utmost importance for the biotic interactions between animals and their predators/
parasites; many of these semiochemicals are emitted for defence purposes. One of the most deterrent and toxic
biogenic substances we know of is hydrogen cyanide, which can be stored by certain insects, millipedes, centipedes
and arachnids in the form of stable and less volatile molecules. The aim of this study was to analyse the
biology and chemistry of such a defence mechanism in a geophilomorph centipede (Chilopoda). The cyanogenic
secretion of Clinopodes flavidus is discharged from the ventral glands, whose glandular units are located in the
space between the cuticle and the trunk muscles and do not extend deep into the segment. In addition to
hydrogen cyanide, the ventral secretion contains 2-methylpentanoic acid, benzaldehyde, benzoyl cyanide, 2-
methyl branched C-9 carboxylic acid (tentatively identified as 2-methyloctanoic acid), methyl 2-phenylacetate,
benzoic acid and mandelonitrile as well as four major proteins with a molecular weight of 150, 66.2, 59 and 55
kDa. The correlation between the presence of ventral glands and guarding with the female’s ventral side facing
away from the eggs and young indicates a functional link between these two traits. We hope that the specificity of
the chemical composition of the ventral secretion could serve as a criterion for chemotaxonomy and that the
analysis of more species will help to clarify the phylogenetic relationships within the Geophilomorpha.
PB  - Elsevier
T2  - Journal of Insect Physiology
T1  - Chemical defence of a centipede (Clinopodes flavidus)
VL  - 155
SP  - 104649
DO  - 10.1016/j.jinsphys.2024.104649
ER  - 

@article{
author = "Mitić, Bojan and Jovanović, Vesna B. and Todosijević, Marina M. and Eckhard, Margret and Vasiljević, Ljubica and Tešević, Vele and Vujisić, Ljubodrag",
year = "2024",
abstract = "Chemical substances are of utmost importance for the biotic interactions between animals and their predators/
parasites; many of these semiochemicals are emitted for defence purposes. One of the most deterrent and toxic
biogenic substances we know of is hydrogen cyanide, which can be stored by certain insects, millipedes, centipedes
and arachnids in the form of stable and less volatile molecules. The aim of this study was to analyse the
biology and chemistry of such a defence mechanism in a geophilomorph centipede (Chilopoda). The cyanogenic
secretion of Clinopodes flavidus is discharged from the ventral glands, whose glandular units are located in the
space between the cuticle and the trunk muscles and do not extend deep into the segment. In addition to
hydrogen cyanide, the ventral secretion contains 2-methylpentanoic acid, benzaldehyde, benzoyl cyanide, 2-
methyl branched C-9 carboxylic acid (tentatively identified as 2-methyloctanoic acid), methyl 2-phenylacetate,
benzoic acid and mandelonitrile as well as four major proteins with a molecular weight of 150, 66.2, 59 and 55
kDa. The correlation between the presence of ventral glands and guarding with the female’s ventral side facing
away from the eggs and young indicates a functional link between these two traits. We hope that the specificity of
the chemical composition of the ventral secretion could serve as a criterion for chemotaxonomy and that the
analysis of more species will help to clarify the phylogenetic relationships within the Geophilomorpha.",
publisher = "Elsevier",
journal = "Journal of Insect Physiology",
title = "Chemical defence of a centipede (Clinopodes flavidus)",
volume = "155",
pages = "104649",
doi = "10.1016/j.jinsphys.2024.104649"
}

Mitić, B., Jovanović, V. B., Todosijević, M. M., Eckhard, M., Vasiljević, L., Tešević, V.,& Vujisić, L.. (2024). Chemical defence of a centipede (Clinopodes flavidus). in Journal of Insect Physiology
Elsevier., 155, 104649.
https://doi.org/10.1016/j.jinsphys.2024.104649

Mitić B, Jovanović VB, Todosijević MM, Eckhard M, Vasiljević L, Tešević V, Vujisić L. Chemical defence of a centipede (Clinopodes flavidus). in Journal of Insect Physiology. 2024;155:104649.
doi:10.1016/j.jinsphys.2024.104649 .

Mitić, Bojan, Jovanović, Vesna B., Todosijević, Marina M., Eckhard, Margret, Vasiljević, Ljubica, Tešević, Vele, Vujisić, Ljubodrag, "Chemical defence of a centipede (Clinopodes flavidus)" in Journal of Insect Physiology, 155 (2024):104649,
https://doi.org/10.1016/j.jinsphys.2024.104649 . .

TY  - JOUR
AU  - Minić, Simeon
AU  - Veličković, Luka
AU  - Annighöfer, Burkhard
AU  - Thureau, Aurélien
AU  - Gligorijević, Nikola
AU  - Jovanović, Zorana
AU  - Brûlet, Annie
AU  - Combet, Sophie
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6595
AB  - The red macroalgae Porphyra, commonly known as Nori, is widely used as food around the world due to its high nutrient content, including the significant abundance of colored phycobiliproteins (PBPs). Among these, R-phycocyanin (R-PC) stands out for its vibrant purple color and numerous bioactive properties, making it a valuable protein for the food industry. However, R-PC's limited thermal stability necessitates alternative processing methods to preserve its color and bioactive properties. Our study aimed to investigate the in-situ stability of oligomeric R-PC under high pressure (HP) conditions (up to 4000 bar) using a combination of absorption, fluorescence, and small-angle X-ray scattering (SAXS) techniques. The unfolding of R-PC is a multiphase process. Initially, low pressure induces conformational changes in the R-PC oligomeric form (trimers). As pressure increases above 1600 bar, these trimers dissociate into monomers, and at pressures above 3000 bar, the subunits begin to unfold. When returned to atmospheric pressure, R-PC partially refolds, retaining 50% of its original color absorbance. In contrast, heat treatment causes irreversible and detrimental effects on R-PC color, highlighting the advantages of HP treatment in preserving both the color and bioactive properties of R-PC compared to heat treatment.
PB  - Wiley
T2  - Protein Science
T1  - Probing the structural stability of R-phycocyanin under pressure
VL  - 33
IS  - 9
SP  - e5145
DO  - 10.1002/pro.5145
ER  - 

@article{
author = "Minić, Simeon and Veličković, Luka and Annighöfer, Burkhard and Thureau, Aurélien and Gligorijević, Nikola and Jovanović, Zorana and Brûlet, Annie and Combet, Sophie",
year = "2024",
abstract = "The red macroalgae Porphyra, commonly known as Nori, is widely used as food around the world due to its high nutrient content, including the significant abundance of colored phycobiliproteins (PBPs). Among these, R-phycocyanin (R-PC) stands out for its vibrant purple color and numerous bioactive properties, making it a valuable protein for the food industry. However, R-PC's limited thermal stability necessitates alternative processing methods to preserve its color and bioactive properties. Our study aimed to investigate the in-situ stability of oligomeric R-PC under high pressure (HP) conditions (up to 4000 bar) using a combination of absorption, fluorescence, and small-angle X-ray scattering (SAXS) techniques. The unfolding of R-PC is a multiphase process. Initially, low pressure induces conformational changes in the R-PC oligomeric form (trimers). As pressure increases above 1600 bar, these trimers dissociate into monomers, and at pressures above 3000 bar, the subunits begin to unfold. When returned to atmospheric pressure, R-PC partially refolds, retaining 50% of its original color absorbance. In contrast, heat treatment causes irreversible and detrimental effects on R-PC color, highlighting the advantages of HP treatment in preserving both the color and bioactive properties of R-PC compared to heat treatment.",
publisher = "Wiley",
journal = "Protein Science",
title = "Probing the structural stability of R-phycocyanin under pressure",
volume = "33",
number = "9",
pages = "e5145",
doi = "10.1002/pro.5145"
}

Minić, S., Veličković, L., Annighöfer, B., Thureau, A., Gligorijević, N., Jovanović, Z., Brûlet, A.,& Combet, S.. (2024). Probing the structural stability of R-phycocyanin under pressure. in Protein Science
Wiley., 33(9), e5145.
https://doi.org/10.1002/pro.5145

Minić S, Veličković L, Annighöfer B, Thureau A, Gligorijević N, Jovanović Z, Brûlet A, Combet S. Probing the structural stability of R-phycocyanin under pressure. in Protein Science. 2024;33(9):e5145.
doi:10.1002/pro.5145 .

Minić, Simeon, Veličković, Luka, Annighöfer, Burkhard, Thureau, Aurélien, Gligorijević, Nikola, Jovanović, Zorana, Brûlet, Annie, Combet, Sophie, "Probing the structural stability of R-phycocyanin under pressure" in Protein Science, 33, no. 9 (2024):e5145,
https://doi.org/10.1002/pro.5145 . .

TY  - JOUR
AU  - Lukić, Marija
AU  - Avdalović, Jelena
AU  - Gojgić-Cvijović, Gordana
AU  - Žerađanin, Aleksandra
AU  - Mrazovac Kurilić, Sanja
AU  - Ilić, Mila
AU  - Miletić, Srđan
AU  - Vrvić, Miroslav
AU  - Beškoski, Vladimir
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6581
AB  - The aim of this paper is to provide insight into research and activities of in situ remediation to remove petroleum hydrocarbon pollutants from a contaminated aquifer’s sediment, located near two radial collector wells of a water supply system. It was decided that the most appropriate method for remediation of this aquifer’s sediment is in situ bioremediation because it is clean, efficient and sustainable technology. Before the start of the bioremediation process, it was necessary to isolate and cultivate the microorganisms present at the contamination site, so they could be later applied in the bioremediation process. The samples before and after the bioremediation were studied using both GC and GC × GC–MS to determine how the concentrations of contaminants changed over time. Additionally, in this paper, a spatiotemporal representation of the change in hydrocarbon content by depth within the zone of the highest contamination over time is shown. After 12 months of bioremediation, the hydrocarbon content in the samples decreased by 82.0%, and based on GCxGC-MS analysis, the order of degradation of various hydrocarbon groups was as follows: steranes (99.6%), isoprenoids (98.4%), benzene derivatives (98.4%), alkanes (97.2%), and terpenes (49.3%). The exponential decay model showed the greatest decomposition rate of hydrocarbons occurred at depths of 8–10 m, with an average decay constant of 0.227, independent of the initial concentration of hydrocarbons. To the best of our knowledge, to date, the described approach has not been applied to an aquifer (the simultaneous treatment of groundwater and its associated sediment layers).
PB  - Springer Link
T2  - Clean Technologies and Environmental Policy
T1  - Industrial-scale bioremediation of a hydrocarbon-contaminated aquifer’s sediment at the location of a heating plant, Belgrade, Serbia
VL  - 26
IS  - 6
SP  - 1785
EP  - 1798
DO  - 10.1007/s10098-023-02724-8
ER  - 

@article{
author = "Lukić, Marija and Avdalović, Jelena and Gojgić-Cvijović, Gordana and Žerađanin, Aleksandra and Mrazovac Kurilić, Sanja and Ilić, Mila and Miletić, Srđan and Vrvić, Miroslav and Beškoski, Vladimir",
year = "2024",
abstract = "The aim of this paper is to provide insight into research and activities of in situ remediation to remove petroleum hydrocarbon pollutants from a contaminated aquifer’s sediment, located near two radial collector wells of a water supply system. It was decided that the most appropriate method for remediation of this aquifer’s sediment is in situ bioremediation because it is clean, efficient and sustainable technology. Before the start of the bioremediation process, it was necessary to isolate and cultivate the microorganisms present at the contamination site, so they could be later applied in the bioremediation process. The samples before and after the bioremediation were studied using both GC and GC × GC–MS to determine how the concentrations of contaminants changed over time. Additionally, in this paper, a spatiotemporal representation of the change in hydrocarbon content by depth within the zone of the highest contamination over time is shown. After 12 months of bioremediation, the hydrocarbon content in the samples decreased by 82.0%, and based on GCxGC-MS analysis, the order of degradation of various hydrocarbon groups was as follows: steranes (99.6%), isoprenoids (98.4%), benzene derivatives (98.4%), alkanes (97.2%), and terpenes (49.3%). The exponential decay model showed the greatest decomposition rate of hydrocarbons occurred at depths of 8–10 m, with an average decay constant of 0.227, independent of the initial concentration of hydrocarbons. To the best of our knowledge, to date, the described approach has not been applied to an aquifer (the simultaneous treatment of groundwater and its associated sediment layers).",
publisher = "Springer Link",
journal = "Clean Technologies and Environmental Policy",
title = "Industrial-scale bioremediation of a hydrocarbon-contaminated aquifer’s sediment at the location of a heating plant, Belgrade, Serbia",
volume = "26",
number = "6",
pages = "1785-1798",
doi = "10.1007/s10098-023-02724-8"
}

Lukić, M., Avdalović, J., Gojgić-Cvijović, G., Žerađanin, A., Mrazovac Kurilić, S., Ilić, M., Miletić, S., Vrvić, M.,& Beškoski, V.. (2024). Industrial-scale bioremediation of a hydrocarbon-contaminated aquifer’s sediment at the location of a heating plant, Belgrade, Serbia. in Clean Technologies and Environmental Policy
Springer Link., 26(6), 1785-1798.
https://doi.org/10.1007/s10098-023-02724-8

Lukić M, Avdalović J, Gojgić-Cvijović G, Žerađanin A, Mrazovac Kurilić S, Ilić M, Miletić S, Vrvić M, Beškoski V. Industrial-scale bioremediation of a hydrocarbon-contaminated aquifer’s sediment at the location of a heating plant, Belgrade, Serbia. in Clean Technologies and Environmental Policy. 2024;26(6):1785-1798.
doi:10.1007/s10098-023-02724-8 .

Lukić, Marija, Avdalović, Jelena, Gojgić-Cvijović, Gordana, Žerađanin, Aleksandra, Mrazovac Kurilić, Sanja, Ilić, Mila, Miletić, Srđan, Vrvić, Miroslav, Beškoski, Vladimir, "Industrial-scale bioremediation of a hydrocarbon-contaminated aquifer’s sediment at the location of a heating plant, Belgrade, Serbia" in Clean Technologies and Environmental Policy, 26, no. 6 (2024):1785-1798,
https://doi.org/10.1007/s10098-023-02724-8 . .

TY  - GEN
AU  - Jednak Berić, Tanja
AU  - Vrvić, Miroslav
AU  - Lješević, Marija
AU  - Avdalović, Jelena
AU  - Ilić, Mila
AU  - Crnković, Dragan
AU  - Jovančićević, Branimir
AU  - Miletić, Srđan
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6580
AB  - Environmental context: Mitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents. Rationale: Bioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies. Methodology: In this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction. Results: In our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased. Discussion: The sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.
PB  - CSIRO Publishing
T2  - Environmental Chemistry
T1  - Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage (pre-publication version)
VL  - 21
IS  - 5
SP  - EN23111
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6580
ER  - 

@misc{
author = "Jednak Berić, Tanja and Vrvić, Miroslav and Lješević, Marija and Avdalović, Jelena and Ilić, Mila and Crnković, Dragan and Jovančićević, Branimir and Miletić, Srđan",
year = "2024",
abstract = "Environmental context: Mitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents. Rationale: Bioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies. Methodology: In this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction. Results: In our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased. Discussion: The sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.",
publisher = "CSIRO Publishing",
journal = "Environmental Chemistry",
title = "Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage (pre-publication version)",
volume = "21",
number = "5",
pages = "EN23111",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6580"
}

Jednak Berić, T., Vrvić, M., Lješević, M., Avdalović, J., Ilić, M., Crnković, D., Jovančićević, B.,& Miletić, S.. (2024). Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage (pre-publication version). in Environmental Chemistry
CSIRO Publishing., 21(5), EN23111.
https://hdl.handle.net/21.15107/rcub_cherry_6580

Jednak Berić T, Vrvić M, Lješević M, Avdalović J, Ilić M, Crnković D, Jovančićević B, Miletić S. Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage (pre-publication version). in Environmental Chemistry. 2024;21(5):EN23111.
https://hdl.handle.net/21.15107/rcub_cherry_6580 .

Jednak Berić, Tanja, Vrvić, Miroslav, Lješević, Marija, Avdalović, Jelena, Ilić, Mila, Crnković, Dragan, Jovančićević, Branimir, Miletić, Srđan, "Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage (pre-publication version)" in Environmental Chemistry, 21, no. 5 (2024):EN23111,
https://hdl.handle.net/21.15107/rcub_cherry_6580 .