TY  - JOUR
AU  - Sakan, Sanja M.
AU  - Frančišković-Bilinski, Stanislav
AU  - Đorđević, Dragana S.
AU  - Popović, Aleksandar R.
AU  - Škrivanj, Sandra B.
AU  - Bilinski, Halka
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4038
AB  - This study investigated the quality of Kupa River sediment using sequential extraction, ecological risk, and contamination indexes (Risk assessment code, Index of geoaccumulation, Enrichment factor, Ecological risk factor, Ecological risk index), determination of magnetic susceptibility of sediments, and statistical methods. The BCR sequential extraction technique was used for evaluating various element-binding forms. Most of the elements were considered to be immobile due to the high availability in the residual fraction. Lead was present mainly in the reducible fraction, while more easily mobile and bioavailable forms were predominant for cadmium and barium. Sediment samples from the river catchment exhibited low ecological risk. The most toxic element, Cd, is the main contributor to the total potentially ecological risk. Increased values of contamination factors have been observed for Zn, Cr, and Ba in some localities. Results of the comparison of element contents in sediments in a 15-year period (2018 vs. 2003) indicated that the situation with toxic element content in sediments along Kupa River improved formost of its course. Unfortunately, on the lower course of the river, the situation has worsened. Using the example of Kupa River sediments, it was shown that the magnetic susceptibility method is excellent indetecting increased values of Cr.
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
T2  - Water
T1  - Geochemical Fractionation and Risk Assessment of Potentially Toxic Elements in Sediments from Kupa River, Croatia
VL  - 12
IS  - 7
SP  - 2024
DO  - 10.3390/w12072024
ER  - 

@article{
author = "Sakan, Sanja M. and Frančišković-Bilinski, Stanislav and Đorđević, Dragana S. and Popović, Aleksandar R. and Škrivanj, Sandra B. and Bilinski, Halka",
year = "2020",
abstract = "This study investigated the quality of Kupa River sediment using sequential extraction, ecological risk, and contamination indexes (Risk assessment code, Index of geoaccumulation, Enrichment factor, Ecological risk factor, Ecological risk index), determination of magnetic susceptibility of sediments, and statistical methods. The BCR sequential extraction technique was used for evaluating various element-binding forms. Most of the elements were considered to be immobile due to the high availability in the residual fraction. Lead was present mainly in the reducible fraction, while more easily mobile and bioavailable forms were predominant for cadmium and barium. Sediment samples from the river catchment exhibited low ecological risk. The most toxic element, Cd, is the main contributor to the total potentially ecological risk. Increased values of contamination factors have been observed for Zn, Cr, and Ba in some localities. Results of the comparison of element contents in sediments in a 15-year period (2018 vs. 2003) indicated that the situation with toxic element content in sediments along Kupa River improved formost of its course. Unfortunately, on the lower course of the river, the situation has worsened. Using the example of Kupa River sediments, it was shown that the magnetic susceptibility method is excellent indetecting increased values of Cr.",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
journal = "Water",
title = "Geochemical Fractionation and Risk Assessment of Potentially Toxic Elements in Sediments from Kupa River, Croatia",
volume = "12",
number = "7",
pages = "2024",
doi = "10.3390/w12072024"
}

Sakan, S. M., Frančišković-Bilinski, S., Đorđević, D. S., Popović, A. R., Škrivanj, S. B.,& Bilinski, H.. (2020). Geochemical Fractionation and Risk Assessment of Potentially Toxic Elements in Sediments from Kupa River, Croatia. in Water
Multidisciplinary Digital Publishing Institute (MDPI)., 12(7), 2024.
https://doi.org/10.3390/w12072024

Sakan SM, Frančišković-Bilinski S, Đorđević DS, Popović AR, Škrivanj SB, Bilinski H. Geochemical Fractionation and Risk Assessment of Potentially Toxic Elements in Sediments from Kupa River, Croatia. in Water. 2020;12(7):2024.
doi:10.3390/w12072024 .

Sakan, Sanja M., Frančišković-Bilinski, Stanislav, Đorđević, Dragana S., Popović, Aleksandar R., Škrivanj, Sandra B., Bilinski, Halka, "Geochemical Fractionation and Risk Assessment of Potentially Toxic Elements in Sediments from Kupa River, Croatia" in Water, 12, no. 7 (2020):2024,
https://doi.org/10.3390/w12072024 . .

TY  - JOUR
AU  - Jurica, Karlo
AU  - Brčić-Karačonji, Irena
AU  - Mikolić, Anja
AU  - Milojković-Opsenica, Dušanka
AU  - Benković, Vesna
AU  - Kopjar, Nevenka
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2194
AB  - Strawberry tree (Arbutus unedo L.) leaves have long been used in the traditional medicine of the Mediterranean region. One of their most bioactive constituents is the glycoside arbutin, whose presence makes A. unedo suitable as a potential substitute for bearberry [Arctostaphylos uva ursi (L.) Spreng] leaves, an herbal preparation widely used for treating urinary tract infections. The safety and biocompatibility of strawberry tree water leaf extract have not yet been documented well. This study estimated arbutin content in strawberry tree water leaf extract (STE) using high performance liquid chromatography. Furthermore, we performed an in vitro safety assessment of the 24 h exposure to three presumably non-toxic concentrations of standardized STE and arbutin in human peripheral blood lymphocytes using the apoptosis/necrosis assay, the alkaline comet assay, and the cytokinesis-block micronucleus cytome assay. The STE was also tested for total antioxidant capacity and lipid peroxidation. At a concentration corresponding to the maximum allowable daily intake of arbutin, the tested extract was not cytotoxic, had a negligible potential for causing primary DNA damage and even hindered micronuclei formation in lymphocytes. It also showed a valuable antioxidant capacity, and did not exert marked lipid peroxidation. These promising results represent a solid frame for further development of STE-based herbal preparations. Although arbutin generally had a low DNA damaging potential, the slowing down of lymphocyte proliferation observed after 24 h of exposure points to a cytostatic effect, which merits further research.
PB  - Springer, Dordrecht
T2  - Cytotechnology
T1  - In vitro safety assessment of the strawberry tree (Arbutus unedo L.) water leaf extract and arbutin in human peripheral blood lymphocytes
VL  - 70
IS  - 4
SP  - 1261
EP  - 1278
DO  - 10.1007/s10616-018-0218-4
ER  - 

@article{
author = "Jurica, Karlo and Brčić-Karačonji, Irena and Mikolić, Anja and Milojković-Opsenica, Dušanka and Benković, Vesna and Kopjar, Nevenka",
year = "2018",
abstract = "Strawberry tree (Arbutus unedo L.) leaves have long been used in the traditional medicine of the Mediterranean region. One of their most bioactive constituents is the glycoside arbutin, whose presence makes A. unedo suitable as a potential substitute for bearberry [Arctostaphylos uva ursi (L.) Spreng] leaves, an herbal preparation widely used for treating urinary tract infections. The safety and biocompatibility of strawberry tree water leaf extract have not yet been documented well. This study estimated arbutin content in strawberry tree water leaf extract (STE) using high performance liquid chromatography. Furthermore, we performed an in vitro safety assessment of the 24 h exposure to three presumably non-toxic concentrations of standardized STE and arbutin in human peripheral blood lymphocytes using the apoptosis/necrosis assay, the alkaline comet assay, and the cytokinesis-block micronucleus cytome assay. The STE was also tested for total antioxidant capacity and lipid peroxidation. At a concentration corresponding to the maximum allowable daily intake of arbutin, the tested extract was not cytotoxic, had a negligible potential for causing primary DNA damage and even hindered micronuclei formation in lymphocytes. It also showed a valuable antioxidant capacity, and did not exert marked lipid peroxidation. These promising results represent a solid frame for further development of STE-based herbal preparations. Although arbutin generally had a low DNA damaging potential, the slowing down of lymphocyte proliferation observed after 24 h of exposure points to a cytostatic effect, which merits further research.",
publisher = "Springer, Dordrecht",
journal = "Cytotechnology",
title = "In vitro safety assessment of the strawberry tree (Arbutus unedo L.) water leaf extract and arbutin in human peripheral blood lymphocytes",
volume = "70",
number = "4",
pages = "1261-1278",
doi = "10.1007/s10616-018-0218-4"
}

Jurica, K., Brčić-Karačonji, I., Mikolić, A., Milojković-Opsenica, D., Benković, V.,& Kopjar, N.. (2018). In vitro safety assessment of the strawberry tree (Arbutus unedo L.) water leaf extract and arbutin in human peripheral blood lymphocytes. in Cytotechnology
Springer, Dordrecht., 70(4), 1261-1278.
https://doi.org/10.1007/s10616-018-0218-4

Jurica K, Brčić-Karačonji I, Mikolić A, Milojković-Opsenica D, Benković V, Kopjar N. In vitro safety assessment of the strawberry tree (Arbutus unedo L.) water leaf extract and arbutin in human peripheral blood lymphocytes. in Cytotechnology. 2018;70(4):1261-1278.
doi:10.1007/s10616-018-0218-4 .

Jurica, Karlo, Brčić-Karačonji, Irena, Mikolić, Anja, Milojković-Opsenica, Dušanka, Benković, Vesna, Kopjar, Nevenka, "In vitro safety assessment of the strawberry tree (Arbutus unedo L.) water leaf extract and arbutin in human peripheral blood lymphocytes" in Cytotechnology, 70, no. 4 (2018):1261-1278,
https://doi.org/10.1007/s10616-018-0218-4 . .