Department of Defense Chemical Biological Defense Program through Defense Threat Reduction Agency (DTRA)

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Department of Defense Chemical Biological Defense Program through Defense Threat Reduction Agency (DTRA)

Authors

Publications

Supplementary data for the article: Selaković, Z.; Soloveva, V.; Gharaibeh, D. N.; Wells, J.; Šegan, S.; Panchal, R. G.; Šolaja, B. A. Anti-Ebola Activity of Diazachrysene Small Molecules. ACS Infectious Diseases 2016, 1 (6), 264–271. https://doi.org/10.1021/acsinfecdis.5b00028

Selaković, Života; Soloveva, Veronica; Gharaibeh, Dima N.; Wells, Jay; Šegan, Sandra B.; Panchal, Rekha G.; Šolaja, Bogdan A.

(Amer Chemical Soc, Washington, 2015) 

TY  - DATA
AU  - Selaković, Života
AU  - Soloveva, Veronica
AU  - Gharaibeh, Dima N.
AU  - Wells, Jay
AU  - Šegan, Sandra B.
AU  - Panchal, Rekha G.
AU  - Šolaja, Bogdan A.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3339
PB  - Amer Chemical Soc, Washington
T2  - ACS INFECTIOUS DISEASES
T1  - Supplementary data for the article: Selaković, Z.; Soloveva, V.; Gharaibeh, D. N.; Wells, J.; Šegan, S.; Panchal, R. G.; Šolaja, B. A. Anti-Ebola Activity of Diazachrysene Small Molecules. ACS Infectious Diseases 2016, 1 (6), 264–271. https://doi.org/10.1021/acsinfecdis.5b00028
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3339
ER  - 
@misc{
author = "Selaković, Života and Soloveva, Veronica and Gharaibeh, Dima N. and Wells, Jay and Šegan, Sandra B. and Panchal, Rekha G. and Šolaja, Bogdan A.",
year = "2015",
publisher = "Amer Chemical Soc, Washington",
journal = "ACS INFECTIOUS DISEASES",
title = "Supplementary data for the article: Selaković, Z.; Soloveva, V.; Gharaibeh, D. N.; Wells, J.; Šegan, S.; Panchal, R. G.; Šolaja, B. A. Anti-Ebola Activity of Diazachrysene Small Molecules. ACS Infectious Diseases 2016, 1 (6), 264–271. https://doi.org/10.1021/acsinfecdis.5b00028",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3339"
}
Selaković, Ž., Soloveva, V., Gharaibeh, D. N., Wells, J., Šegan, S. B., Panchal, R. G.,& Šolaja, B. A.. (2015). Supplementary data for the article: Selaković, Z.; Soloveva, V.; Gharaibeh, D. N.; Wells, J.; Šegan, S.; Panchal, R. G.; Šolaja, B. A. Anti-Ebola Activity of Diazachrysene Small Molecules. ACS Infectious Diseases 2016, 1 (6), 264–271. https://doi.org/10.1021/acsinfecdis.5b00028. in ACS INFECTIOUS DISEASES
Amer Chemical Soc, Washington..
https://hdl.handle.net/21.15107/rcub_cherry_3339
Selaković Ž, Soloveva V, Gharaibeh DN, Wells J, Šegan SB, Panchal RG, Šolaja BA. Supplementary data for the article: Selaković, Z.; Soloveva, V.; Gharaibeh, D. N.; Wells, J.; Šegan, S.; Panchal, R. G.; Šolaja, B. A. Anti-Ebola Activity of Diazachrysene Small Molecules. ACS Infectious Diseases 2016, 1 (6), 264–271. https://doi.org/10.1021/acsinfecdis.5b00028. in ACS INFECTIOUS DISEASES. 2015;.
https://hdl.handle.net/21.15107/rcub_cherry_3339 .
Selaković, Života, Soloveva, Veronica, Gharaibeh, Dima N., Wells, Jay, Šegan, Sandra B., Panchal, Rekha G., Šolaja, Bogdan A., "Supplementary data for the article: Selaković, Z.; Soloveva, V.; Gharaibeh, D. N.; Wells, J.; Šegan, S.; Panchal, R. G.; Šolaja, B. A. Anti-Ebola Activity of Diazachrysene Small Molecules. ACS Infectious Diseases 2016, 1 (6), 264–271. https://doi.org/10.1021/acsinfecdis.5b00028" in ACS INFECTIOUS DISEASES (2015),
https://hdl.handle.net/21.15107/rcub_cherry_3339 .

Anti-Ebola Activity of Diazachrysene Small Molecules

Selaković, Života; Soloveva, Veronica; Gharaibeh, Dima N.; Wells, Jay; Šegan, Sandra B.; Panchal, Rekha G.; Šolaja, Bogdan A.

(Amer Chemical Soc, Washington, 2015) 

TY  - JOUR
AU  - Selaković, Života
AU  - Soloveva, Veronica
AU  - Gharaibeh, Dima N.
AU  - Wells, Jay
AU  - Šegan, Sandra B.
AU  - Panchal, Rekha G.
AU  - Šolaja, Bogdan A.
PY  - 2015
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2035
AB  - Herein we report on a diazachrysene class of small molecules that exhibit potent antiviral activity against the Ebola (EBOV) virus. The antiviral compounds are easily synthesized, and the most active compounds have excellent in vitro activity (0.34-0.70 mu M) and are significantly less lipophilic than their predecessors. The three most potent diazachrysene antivirals do not exhibit any toxicity in vivo and protected 70-90% of the mice at 10 mg/kg following EBOV challenge. Together, these studies suggest that diazachrysenes are a promising class of compounds for hit to lead optimization and as potential Ebola therapeutics.
PB  - Amer Chemical Soc, Washington
T2  - ACS INFECTIOUS DISEASES
T1  - Anti-Ebola Activity of Diazachrysene Small Molecules
VL  - 1
IS  - 6
SP  - 264
EP  - 271
DO  - 10.1021/acsinfecdis.5b00028
ER  - 
@article{
author = "Selaković, Života and Soloveva, Veronica and Gharaibeh, Dima N. and Wells, Jay and Šegan, Sandra B. and Panchal, Rekha G. and Šolaja, Bogdan A.",
year = "2015",
abstract = "Herein we report on a diazachrysene class of small molecules that exhibit potent antiviral activity against the Ebola (EBOV) virus. The antiviral compounds are easily synthesized, and the most active compounds have excellent in vitro activity (0.34-0.70 mu M) and are significantly less lipophilic than their predecessors. The three most potent diazachrysene antivirals do not exhibit any toxicity in vivo and protected 70-90% of the mice at 10 mg/kg following EBOV challenge. Together, these studies suggest that diazachrysenes are a promising class of compounds for hit to lead optimization and as potential Ebola therapeutics.",
publisher = "Amer Chemical Soc, Washington",
journal = "ACS INFECTIOUS DISEASES",
title = "Anti-Ebola Activity of Diazachrysene Small Molecules",
volume = "1",
number = "6",
pages = "264-271",
doi = "10.1021/acsinfecdis.5b00028"
}
Selaković, Ž., Soloveva, V., Gharaibeh, D. N., Wells, J., Šegan, S. B., Panchal, R. G.,& Šolaja, B. A.. (2015). Anti-Ebola Activity of Diazachrysene Small Molecules. in ACS INFECTIOUS DISEASES
Amer Chemical Soc, Washington., 1(6), 264-271.
https://doi.org/10.1021/acsinfecdis.5b00028
Selaković Ž, Soloveva V, Gharaibeh DN, Wells J, Šegan SB, Panchal RG, Šolaja BA. Anti-Ebola Activity of Diazachrysene Small Molecules. in ACS INFECTIOUS DISEASES. 2015;1(6):264-271.
doi:10.1021/acsinfecdis.5b00028 .
Selaković, Života, Soloveva, Veronica, Gharaibeh, Dima N., Wells, Jay, Šegan, Sandra B., Panchal, Rekha G., Šolaja, Bogdan A., "Anti-Ebola Activity of Diazachrysene Small Molecules" in ACS INFECTIOUS DISEASES, 1, no. 6 (2015):264-271,
https://doi.org/10.1021/acsinfecdis.5b00028 . .
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