TY  - JOUR
AU  - Mijatović, Aleksandar
AU  - Cakovic, Angelina
AU  - Lolić, Aleksandar
AU  - Sretenovic, Snezana
AU  - Zivanovic, Marko
AU  - Petrović, Biljana
AU  - Bogojeski, Jovana
AU  - Seklic, Dragana
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6458
AB  - Three Schiff base Cu(II) complexes, (N,N’-bis(acetylacetone)­propyl­enediimine)copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-(ben­zoyl­acet­one)propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N’-bis-(trifluoroacetylacetone)propylenediimine)­copper(II) complex, [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic absorption and spectro­scopic fluorescence methods. UV–Vis absorption studies showed that studied complexes interact with DNA molecule and exhibit moderate binding affinity. Fluorescence studies of complexes 1–3 also showed a possibility for DNA int­ercalation as well as a relatively high binding ability toward BSA. Among the tested complexes, the highest affinity for DNA and BSA molecules was shown by complex 1. Cytotoxic analyses, performed on human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showed that complex 2 exhibited activity on both cell lines, while complexes 1 and 3 did not show any activity.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper
VL  - 88
IS  - 12
SP  - 1307
EP  - 1317
DO  - 10.2298/JSC230614063M
ER  - 

@article{
author = "Mijatović, Aleksandar and Cakovic, Angelina and Lolić, Aleksandar and Sretenovic, Snezana and Zivanovic, Marko and Petrović, Biljana and Bogojeski, Jovana and Seklic, Dragana",
year = "2023",
abstract = "Three Schiff base Cu(II) complexes, (N,N’-bis(acetylacetone)­propyl­enediimine)copper(II) complex, [Cu(acac2pn)] (1), (N,N'-bis-(ben­zoyl­acet­one)propylenediimine)copper(II) complex, [Cu(phacac2pn)] (2) and (N,N’-bis-(trifluoroacetylacetone)propylenediimine)­copper(II) complex, [Cu(tfacac2pn)] (3), were used to investigate the interactions with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) using the electronic absorption and spectro­scopic fluorescence methods. UV–Vis absorption studies showed that studied complexes interact with DNA molecule and exhibit moderate binding affinity. Fluorescence studies of complexes 1–3 also showed a possibility for DNA int­ercalation as well as a relatively high binding ability toward BSA. Among the tested complexes, the highest affinity for DNA and BSA molecules was shown by complex 1. Cytotoxic analyses, performed on human colorectal carcinoma HCT-116 and healthy lung fibroblast MRC-5 cell lines, showed that complex 2 exhibited activity on both cell lines, while complexes 1 and 3 did not show any activity.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper",
volume = "88",
number = "12",
pages = "1307-1317",
doi = "10.2298/JSC230614063M"
}

Mijatović, A., Cakovic, A., Lolić, A., Sretenovic, S., Zivanovic, M., Petrović, B., Bogojeski, J.,& Seklic, D.. (2023). DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 88(12), 1307-1317.
https://doi.org/10.2298/JSC230614063M

Mijatović A, Cakovic A, Lolić A, Sretenovic S, Zivanovic M, Petrović B, Bogojeski J, Seklic D. DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper. in Journal of the Serbian Chemical Society. 2023;88(12):1307-1317.
doi:10.2298/JSC230614063M .

Mijatović, Aleksandar, Cakovic, Angelina, Lolić, Aleksandar, Sretenovic, Snezana, Zivanovic, Marko, Petrović, Biljana, Bogojeski, Jovana, Seklic, Dragana, "DNA/BSA interactions and cytotoxic studies of tetradentate N,N,O,O-Schiff base copper(II) complexes: Scientific paper" in Journal of the Serbian Chemical Society, 88, no. 12 (2023):1307-1317,
https://doi.org/10.2298/JSC230614063M . .

TY  - JOUR
AU  - Međedović, Milica
AU  - Mijatović, Aleksandar
AU  - Baošić, Rada
AU  - Lazić, Dejan
AU  - Milanović, Žiko
AU  - Marković, Zoran
AU  - Milovanović, Jelena
AU  - Arsenijević, Dragana
AU  - Stojanović, Bojana
AU  - Arsenijević, Miloš
AU  - Milovanović, Marija
AU  - Petrović, Biljana
AU  - Rilak Simović, Ana
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6353
AB  - In order to discover new anticancer drugs, novel ruthenium(III) complexes [Ru(L)Cl(H2O)], where L is tetradentate Schiff base bis(acetylacetone)ethylendiimine (acacen, 1), bis(benzoylacetone)ethylendiimine (bzacen, 2), (acetylacetone)(benzoylaceton)ethylendiimine (acacbzacen, 3), bis(acetylacetone)propylendiimine (acacpn, 4), bis(benzoylacetone)propylendiimine (bzacpn, 5) or (acetylacetone)(benzoylaceton)propylendiimine (acacbzacpn, 6), were synthesized. The complexes 1 – 6 were characterized by elemental analysis, molar conductometry, and by various spectroscopic techniques, such as UV–Vis, IR, EPR, and ESI-MS. Based on in vitro DNA/BSA experiments, complexes 2 (bzacen) and 5 (bzacpn) with two aromatic rings showed the highest DNA/BSA-activity, suggesting that the presence of the aromatic ring on the tetradentate Schiff base ligand contributes to increased activity. Moreover, these two compounds showed the highest cytotoxic effects toward human, A549 and murine LLC1 lung cancer cells. These complexes altered the ratio of anti- and pro-apoptotic molecules and induced apoptosis of A549 cells. Further, complexes 2 and 5 reduced the percentage of Mcl1 and Bcl2 expressing LLC1 cells, induced their apoptotic death and exerted an antiproliferative effect against LLC1. Finally, complex 5 reduced the volume of mouse primary heterotopic Lewis lung cancer, while complex 2 reduced the incidence and mean number of metastases per lung. Additionally, molecular docking with DNA revealed that the reduced number of aromatic rings or their absence causes lower intercalative properties of the complexes in order: 2 > 5 > 6 > 3 > 4 > 1. It was observed that conventional hydrogen bonds and hydrophobic interactions contribute to the stabilization of the structures of complex-DNA. A molecular docking study with BSA revealed a predominance of 1 – 6 in binding affinity to the active site III, a third D-shaped hydrophobic pocket within subdomain IB.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes
VL  - 248
SP  - 112363
DO  - 10.1016/j.jinorgbio.2023.112363
ER  - 

@article{
author = "Međedović, Milica and Mijatović, Aleksandar and Baošić, Rada and Lazić, Dejan and Milanović, Žiko and Marković, Zoran and Milovanović, Jelena and Arsenijević, Dragana and Stojanović, Bojana and Arsenijević, Miloš and Milovanović, Marija and Petrović, Biljana and Rilak Simović, Ana",
year = "2023",
abstract = "In order to discover new anticancer drugs, novel ruthenium(III) complexes [Ru(L)Cl(H2O)], where L is tetradentate Schiff base bis(acetylacetone)ethylendiimine (acacen, 1), bis(benzoylacetone)ethylendiimine (bzacen, 2), (acetylacetone)(benzoylaceton)ethylendiimine (acacbzacen, 3), bis(acetylacetone)propylendiimine (acacpn, 4), bis(benzoylacetone)propylendiimine (bzacpn, 5) or (acetylacetone)(benzoylaceton)propylendiimine (acacbzacpn, 6), were synthesized. The complexes 1 – 6 were characterized by elemental analysis, molar conductometry, and by various spectroscopic techniques, such as UV–Vis, IR, EPR, and ESI-MS. Based on in vitro DNA/BSA experiments, complexes 2 (bzacen) and 5 (bzacpn) with two aromatic rings showed the highest DNA/BSA-activity, suggesting that the presence of the aromatic ring on the tetradentate Schiff base ligand contributes to increased activity. Moreover, these two compounds showed the highest cytotoxic effects toward human, A549 and murine LLC1 lung cancer cells. These complexes altered the ratio of anti- and pro-apoptotic molecules and induced apoptosis of A549 cells. Further, complexes 2 and 5 reduced the percentage of Mcl1 and Bcl2 expressing LLC1 cells, induced their apoptotic death and exerted an antiproliferative effect against LLC1. Finally, complex 5 reduced the volume of mouse primary heterotopic Lewis lung cancer, while complex 2 reduced the incidence and mean number of metastases per lung. Additionally, molecular docking with DNA revealed that the reduced number of aromatic rings or their absence causes lower intercalative properties of the complexes in order: 2 > 5 > 6 > 3 > 4 > 1. It was observed that conventional hydrogen bonds and hydrophobic interactions contribute to the stabilization of the structures of complex-DNA. A molecular docking study with BSA revealed a predominance of 1 – 6 in binding affinity to the active site III, a third D-shaped hydrophobic pocket within subdomain IB.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes",
volume = "248",
pages = "112363",
doi = "10.1016/j.jinorgbio.2023.112363"
}

Međedović, M., Mijatović, A., Baošić, R., Lazić, D., Milanović, Ž., Marković, Z., Milovanović, J., Arsenijević, D., Stojanović, B., Arsenijević, M., Milovanović, M., Petrović, B.,& Rilak Simović, A.. (2023). Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes. in Journal of Inorganic Biochemistry
Elsevier., 248, 112363.
https://doi.org/10.1016/j.jinorgbio.2023.112363

Međedović M, Mijatović A, Baošić R, Lazić D, Milanović Ž, Marković Z, Milovanović J, Arsenijević D, Stojanović B, Arsenijević M, Milovanović M, Petrović B, Rilak Simović A. Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes. in Journal of Inorganic Biochemistry. 2023;248:112363.
doi:10.1016/j.jinorgbio.2023.112363 .

Međedović, Milica, Mijatović, Aleksandar, Baošić, Rada, Lazić, Dejan, Milanović, Žiko, Marković, Zoran, Milovanović, Jelena, Arsenijević, Dragana, Stojanović, Bojana, Arsenijević, Miloš, Milovanović, Marija, Petrović, Biljana, Rilak Simović, Ana, "Synthesis, characterization, biomolecular interactions, molecular docking, and in vitro and in vivo anticancer activities of novel ruthenium(III) Schiff base complexes" in Journal of Inorganic Biochemistry, 248 (2023):112363,
https://doi.org/10.1016/j.jinorgbio.2023.112363 . .

TY  - JOUR
AU  - Petrović, Milena M.
AU  - Roschger, Cornelia
AU  - Lang, Kevin
AU  - Zierer, Andreas
AU  - Mladenović, Milan
AU  - Trifunović, Snežana S.
AU  - Mandić, Boris
AU  - Joksović, Milan D.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5696
AB  - Fourteen novel quinoline-4-carboxylic acid-chalcone hybrids were obtained via Claisen–Schmidt condensation and evaluated as potential human dihydroorotate dehydrogenase (hDHODH) inhibitors. The ketone precursor 2 was synthesized by the Pfitzinger reaction and used for further derivatization at position 3 of the quinoline ring for the first time. Six compounds showed better hDHODH inhibitory activity than the reference drug leflunomide, with IC50 values ranging from 0.12 to 0.58 μM. The bioactive conformations of the compounds within hDHODH were resolved by means of molecular docking, revealing their tendency to occupy the narrow tunnel of hDHODH within the N-terminus and to prevent ubiquinone as the second cofactor from easily approaching the flavin mononucleotide as a cofactor for the redox reaction within the redox site. The results of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed that 4d and 4h demonstrated the highest cytotoxic activity against the A375 cell line, with IC50 values of 5.0 and 6.8 µM, respectively. The lipophilicity of the synthesized hybrids was obtained experimentally and expressed as logD7.4 values at physiologicalpH while the solubility assay was conducted to define physicochemical characteristics influencing the ADMET properties.
PB  - Wiley
T2  - Archiv der Pharmazie
T1  - Synthesis and biological evaluation of new quinoline-4-carboxylic acid-chalcone hybrids as dihydroorotate dehydrogenase inhibitors
VL  - 356
IS  - 2
SP  - e2200374
DO  - 10.1002/ardp.202200374
ER  - 

@article{
author = "Petrović, Milena M. and Roschger, Cornelia and Lang, Kevin and Zierer, Andreas and Mladenović, Milan and Trifunović, Snežana S. and Mandić, Boris and Joksović, Milan D.",
year = "2023",
abstract = "Fourteen novel quinoline-4-carboxylic acid-chalcone hybrids were obtained via Claisen–Schmidt condensation and evaluated as potential human dihydroorotate dehydrogenase (hDHODH) inhibitors. The ketone precursor 2 was synthesized by the Pfitzinger reaction and used for further derivatization at position 3 of the quinoline ring for the first time. Six compounds showed better hDHODH inhibitory activity than the reference drug leflunomide, with IC50 values ranging from 0.12 to 0.58 μM. The bioactive conformations of the compounds within hDHODH were resolved by means of molecular docking, revealing their tendency to occupy the narrow tunnel of hDHODH within the N-terminus and to prevent ubiquinone as the second cofactor from easily approaching the flavin mononucleotide as a cofactor for the redox reaction within the redox site. The results of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed that 4d and 4h demonstrated the highest cytotoxic activity against the A375 cell line, with IC50 values of 5.0 and 6.8 µM, respectively. The lipophilicity of the synthesized hybrids was obtained experimentally and expressed as logD7.4 values at physiologicalpH while the solubility assay was conducted to define physicochemical characteristics influencing the ADMET properties.",
publisher = "Wiley",
journal = "Archiv der Pharmazie",
title = "Synthesis and biological evaluation of new quinoline-4-carboxylic acid-chalcone hybrids as dihydroorotate dehydrogenase inhibitors",
volume = "356",
number = "2",
pages = "e2200374",
doi = "10.1002/ardp.202200374"
}

Petrović, M. M., Roschger, C., Lang, K., Zierer, A., Mladenović, M., Trifunović, S. S., Mandić, B.,& Joksović, M. D.. (2023). Synthesis and biological evaluation of new quinoline-4-carboxylic acid-chalcone hybrids as dihydroorotate dehydrogenase inhibitors. in Archiv der Pharmazie
Wiley., 356(2), e2200374.
https://doi.org/10.1002/ardp.202200374

Petrović MM, Roschger C, Lang K, Zierer A, Mladenović M, Trifunović SS, Mandić B, Joksović MD. Synthesis and biological evaluation of new quinoline-4-carboxylic acid-chalcone hybrids as dihydroorotate dehydrogenase inhibitors. in Archiv der Pharmazie. 2023;356(2):e2200374.
doi:10.1002/ardp.202200374 .

Petrović, Milena M., Roschger, Cornelia, Lang, Kevin, Zierer, Andreas, Mladenović, Milan, Trifunović, Snežana S., Mandić, Boris, Joksović, Milan D., "Synthesis and biological evaluation of new quinoline-4-carboxylic acid-chalcone hybrids as dihydroorotate dehydrogenase inhibitors" in Archiv der Pharmazie, 356, no. 2 (2023):e2200374,
https://doi.org/10.1002/ardp.202200374 . .

TY  - JOUR
AU  - Zlatić, Nenad
AU  - Mihailović, Vladimir
AU  - Lješević, Marija
AU  - Beškoski, Vladimir
AU  - Stanković, Milan
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5004
AB  - This study aimed to determine the qualitative variability of essential oils of mountain germander – Teucrium
montanum L. (Lamiaceae) at the population level, depending on the type of geological substrate. Ten samples of
essential oils originated from aerial plant parts of populations from calcareous and ten from serpentinite were
tested by GCxGC-MS method. The obtained results showed that the serpentinite populations have more than 3
times higher essential oil yield than calcareous populations. Based on the average values for the relative percentage amounts of T. montanum essential oils, it was shown that the sesquiterpenes (34.89%) are the main
compounds in analyzed essential oils. Population from calcareous habitats synthesize twice as many aliphatic
hydrocarbons than populations from serpentinite habitats, while populations from serpentinite habitats synthesize twice as much mono- and sesquiterpenes. The compounds with highest relative percentage amounts in
calcareous populations was the hydrocarbon tetracosane (9.02%), while in serpentinite populations it was
oxygenated sesquiterpene, limonen-10-ol (4.81%). Compounds which were only detected for calcareous populations are: dodecane and isophytol, while for serpentinite populations are: 3-caren-2-ol, carvone oxide and
pyronene. The obtained results indicate a significant influence of the habitat geological substrate on the qualitative characteristics of the T. montanum essential oil. Differentiation of calcareous and serpentinite populations
into two distinct groups based on the essential oil composition indicate the significant presence of specific
chemotypes developed by the influence of various edaphic characteristics.
PB  - Elsevier
T2  - Biochemical Systematics and Ecology
T1  - Geological substrate-related variability of Teucrium montanum L. (Lamiaceae) essential oil
VL  - 100
IS  - 104372
DO  - 10.1016/j.bse.2021.104372
ER  - 

@article{
author = "Zlatić, Nenad and Mihailović, Vladimir and Lješević, Marija and Beškoski, Vladimir and Stanković, Milan",
year = "2022",
abstract = "This study aimed to determine the qualitative variability of essential oils of mountain germander – Teucrium
montanum L. (Lamiaceae) at the population level, depending on the type of geological substrate. Ten samples of
essential oils originated from aerial plant parts of populations from calcareous and ten from serpentinite were
tested by GCxGC-MS method. The obtained results showed that the serpentinite populations have more than 3
times higher essential oil yield than calcareous populations. Based on the average values for the relative percentage amounts of T. montanum essential oils, it was shown that the sesquiterpenes (34.89%) are the main
compounds in analyzed essential oils. Population from calcareous habitats synthesize twice as many aliphatic
hydrocarbons than populations from serpentinite habitats, while populations from serpentinite habitats synthesize twice as much mono- and sesquiterpenes. The compounds with highest relative percentage amounts in
calcareous populations was the hydrocarbon tetracosane (9.02%), while in serpentinite populations it was
oxygenated sesquiterpene, limonen-10-ol (4.81%). Compounds which were only detected for calcareous populations are: dodecane and isophytol, while for serpentinite populations are: 3-caren-2-ol, carvone oxide and
pyronene. The obtained results indicate a significant influence of the habitat geological substrate on the qualitative characteristics of the T. montanum essential oil. Differentiation of calcareous and serpentinite populations
into two distinct groups based on the essential oil composition indicate the significant presence of specific
chemotypes developed by the influence of various edaphic characteristics.",
publisher = "Elsevier",
journal = "Biochemical Systematics and Ecology",
title = "Geological substrate-related variability of Teucrium montanum L. (Lamiaceae) essential oil",
volume = "100",
number = "104372",
doi = "10.1016/j.bse.2021.104372"
}

Zlatić, N., Mihailović, V., Lješević, M., Beškoski, V.,& Stanković, M.. (2022). Geological substrate-related variability of Teucrium montanum L. (Lamiaceae) essential oil. in Biochemical Systematics and Ecology
Elsevier., 100(104372).
https://doi.org/10.1016/j.bse.2021.104372

Zlatić N, Mihailović V, Lješević M, Beškoski V, Stanković M. Geological substrate-related variability of Teucrium montanum L. (Lamiaceae) essential oil. in Biochemical Systematics and Ecology. 2022;100(104372).
doi:10.1016/j.bse.2021.104372 .

Zlatić, Nenad, Mihailović, Vladimir, Lješević, Marija, Beškoski, Vladimir, Stanković, Milan, "Geological substrate-related variability of Teucrium montanum L. (Lamiaceae) essential oil" in Biochemical Systematics and Ecology, 100, no. 104372 (2022),
https://doi.org/10.1016/j.bse.2021.104372 . .

TY  - JOUR
AU  - Kasalović, Marijana P.
AU  - Petrović, Angelina
AU  - Živković, Jelena M.
AU  - Kuckling, Linus
AU  - Jevtić, Verica V.
AU  - Bogojeski, Jovana
AU  - Leka, Zorica B.
AU  - Trifunović, Srećko R.
AU  - Pantelić, Nebojša Đ.
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4436
AB  - Dithiocarbamates, with their high lipophilic character and good chelating properties, could provide stabile transition metal complexes and enable these metal-based drugs to reach their biological targets. Palladium(II) and gold(III) complexes, due to its structural similarity with platinum(II)compounds, could be competitive candidates for implementing and developing new pharmacological agents. Herein, novel gold(III) complex with triammonium N-carboxyiminodiacetate as ligand has been synthesized and characterized by elemental analysis, molar conductivity measurements, FT-IR and 1H and 13C NMR spectroscopy. The proposed structure was examined and compared with analogue palladium(II) and zinc(II) complexes by density functional theory (B3LYP/def2tzvp). Additionally, DNA-binding studies by UV/Vis-spectrometer as well as ethidium-bromide (EB) and bovine serum albumin (BSA) quenching studies by spectrofluorometer were performed for gold(III), palladium(II) and zinc(II) dithiocarbamate complexes. The investigated complexes showed a good affinity to calf thymus DNA (CT-DNA) and BSA, with a higher affinity to BSA. Palladium(II) complex exhibited 5-fold a stronger affinity to DNA binding in comparison to zinc(II), but no significantly higher than gold(III) complex. Furthermore, palladium(II) and gold(III) complexes demonstrated a similar affinity toward BSA and these interactions are stronger than showed by zinc(II) complex.
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate
VL  - 1229
SP  - 129622
DO  - 10.1016/j.molstruc.2020.129622
ER  - 

@article{
author = "Kasalović, Marijana P. and Petrović, Angelina and Živković, Jelena M. and Kuckling, Linus and Jevtić, Verica V. and Bogojeski, Jovana and Leka, Zorica B. and Trifunović, Srećko R. and Pantelić, Nebojša Đ.",
year = "2021",
abstract = "Dithiocarbamates, with their high lipophilic character and good chelating properties, could provide stabile transition metal complexes and enable these metal-based drugs to reach their biological targets. Palladium(II) and gold(III) complexes, due to its structural similarity with platinum(II)compounds, could be competitive candidates for implementing and developing new pharmacological agents. Herein, novel gold(III) complex with triammonium N-carboxyiminodiacetate as ligand has been synthesized and characterized by elemental analysis, molar conductivity measurements, FT-IR and 1H and 13C NMR spectroscopy. The proposed structure was examined and compared with analogue palladium(II) and zinc(II) complexes by density functional theory (B3LYP/def2tzvp). Additionally, DNA-binding studies by UV/Vis-spectrometer as well as ethidium-bromide (EB) and bovine serum albumin (BSA) quenching studies by spectrofluorometer were performed for gold(III), palladium(II) and zinc(II) dithiocarbamate complexes. The investigated complexes showed a good affinity to calf thymus DNA (CT-DNA) and BSA, with a higher affinity to BSA. Palladium(II) complex exhibited 5-fold a stronger affinity to DNA binding in comparison to zinc(II), but no significantly higher than gold(III) complex. Furthermore, palladium(II) and gold(III) complexes demonstrated a similar affinity toward BSA and these interactions are stronger than showed by zinc(II) complex.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate",
volume = "1229",
pages = "129622",
doi = "10.1016/j.molstruc.2020.129622"
}

Kasalović, M. P., Petrović, A., Živković, J. M., Kuckling, L., Jevtić, V. V., Bogojeski, J., Leka, Z. B., Trifunović, S. R.,& Pantelić, N. Đ.. (2021). Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate. in Journal of Molecular Structure
Elsevier., 1229, 129622.
https://doi.org/10.1016/j.molstruc.2020.129622

Kasalović MP, Petrović A, Živković JM, Kuckling L, Jevtić VV, Bogojeski J, Leka ZB, Trifunović SR, Pantelić NĐ. Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate. in Journal of Molecular Structure. 2021;1229:129622.
doi:10.1016/j.molstruc.2020.129622 .

Kasalović, Marijana P., Petrović, Angelina, Živković, Jelena M., Kuckling, Linus, Jevtić, Verica V., Bogojeski, Jovana, Leka, Zorica B., Trifunović, Srećko R., Pantelić, Nebojša Đ., "Evaluation of DNA/BSA interactions and DFT calculations of gold(III), zinc(II) and palladium(II) complexes with triammonium N-dithiocarboxyiminodiacetate" in Journal of Molecular Structure, 1229 (2021):129622,
https://doi.org/10.1016/j.molstruc.2020.129622 . .

TY  - DATA
AU  - Kasalović, Marijana P.
AU  - Petrović, Angelina
AU  - Živković, Jelena M.
AU  - Kuckling, Linus
AU  - Jevtić, Verica V.
AU  - Bogojeski, Jovana
AU  - Leka, Zorica B.
AU  - Trifunović, Srećko R.
AU  - Pantelić, Nebojša Đ.
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4438
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - Supplementary data for the article: Kasalović, M. P.; Petrović, A.; Živković, J. M.; Kuckling, L.; Jevtić, V. V.; Bogojeski, J.; Leka, Z. B.; Trifunović, S. R.; Pantelić, N. Đ. Evaluation of DNA/BSA Interactions and DFT Calculations of Gold(III), Zinc(II) and Palladium(II) Complexes with Triammonium N-Dithiocarboxyiminodiacetate. Journal of Molecular Structure 2021, 1229, 129622. https://doi.org/10.1016/j.molstruc.2020.129622.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4438
ER  - 

@misc{
author = "Kasalović, Marijana P. and Petrović, Angelina and Živković, Jelena M. and Kuckling, Linus and Jevtić, Verica V. and Bogojeski, Jovana and Leka, Zorica B. and Trifunović, Srećko R. and Pantelić, Nebojša Đ.",
year = "2021",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "Supplementary data for the article: Kasalović, M. P.; Petrović, A.; Živković, J. M.; Kuckling, L.; Jevtić, V. V.; Bogojeski, J.; Leka, Z. B.; Trifunović, S. R.; Pantelić, N. Đ. Evaluation of DNA/BSA Interactions and DFT Calculations of Gold(III), Zinc(II) and Palladium(II) Complexes with Triammonium N-Dithiocarboxyiminodiacetate. Journal of Molecular Structure 2021, 1229, 129622. https://doi.org/10.1016/j.molstruc.2020.129622.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4438"
}

Kasalović, M. P., Petrović, A., Živković, J. M., Kuckling, L., Jevtić, V. V., Bogojeski, J., Leka, Z. B., Trifunović, S. R.,& Pantelić, N. Đ.. (2021). Supplementary data for the article: Kasalović, M. P.; Petrović, A.; Živković, J. M.; Kuckling, L.; Jevtić, V. V.; Bogojeski, J.; Leka, Z. B.; Trifunović, S. R.; Pantelić, N. Đ. Evaluation of DNA/BSA Interactions and DFT Calculations of Gold(III), Zinc(II) and Palladium(II) Complexes with Triammonium N-Dithiocarboxyiminodiacetate. Journal of Molecular Structure 2021, 1229, 129622. https://doi.org/10.1016/j.molstruc.2020.129622.. in Journal of Molecular Structure
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4438

Kasalović MP, Petrović A, Živković JM, Kuckling L, Jevtić VV, Bogojeski J, Leka ZB, Trifunović SR, Pantelić NĐ. Supplementary data for the article: Kasalović, M. P.; Petrović, A.; Živković, J. M.; Kuckling, L.; Jevtić, V. V.; Bogojeski, J.; Leka, Z. B.; Trifunović, S. R.; Pantelić, N. Đ. Evaluation of DNA/BSA Interactions and DFT Calculations of Gold(III), Zinc(II) and Palladium(II) Complexes with Triammonium N-Dithiocarboxyiminodiacetate. Journal of Molecular Structure 2021, 1229, 129622. https://doi.org/10.1016/j.molstruc.2020.129622.. in Journal of Molecular Structure. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4438 .

Kasalović, Marijana P., Petrović, Angelina, Živković, Jelena M., Kuckling, Linus, Jevtić, Verica V., Bogojeski, Jovana, Leka, Zorica B., Trifunović, Srećko R., Pantelić, Nebojša Đ., "Supplementary data for the article: Kasalović, M. P.; Petrović, A.; Živković, J. M.; Kuckling, L.; Jevtić, V. V.; Bogojeski, J.; Leka, Z. B.; Trifunović, S. R.; Pantelić, N. Đ. Evaluation of DNA/BSA Interactions and DFT Calculations of Gold(III), Zinc(II) and Palladium(II) Complexes with Triammonium N-Dithiocarboxyiminodiacetate. Journal of Molecular Structure 2021, 1229, 129622. https://doi.org/10.1016/j.molstruc.2020.129622." in Journal of Molecular Structure (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4438 .

TY  - CONF
AU  - Zlatić, Nenad
AU  - Mihailović, Vladimir
AU  - Lješević, Marija
AU  - Beškoski, Vladimir
AU  - Stanković, Milan
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5436
AB  - The aim of this study is to determine the qualitative variability and relative presence of oxygenated monoterpenes in essential oils from Teucrium montanum L. collected from different habitat substrates.
PB  - Belgrade : Faculty of Chemistry
PB  - Belgrade : Serbian Biochemical Society
C3  - Proceedings - Serbian Biochemical Society, 10th Conference, Kragujevac, Serbia, 24.09.2021
T1  - Monoterpens variability in Teucrium montanum L. essential oils. Biochemical insights into molecular mechanisms
SP  - 187
UR  - https://hdl.handle.net/21.15107/rcub_cer_5020
ER  - 

@conference{
author = "Zlatić, Nenad and Mihailović, Vladimir and Lješević, Marija and Beškoski, Vladimir and Stanković, Milan",
year = "2021",
abstract = "The aim of this study is to determine the qualitative variability and relative presence of oxygenated monoterpenes in essential oils from Teucrium montanum L. collected from different habitat substrates.",
publisher = "Belgrade : Faculty of Chemistry, Belgrade : Serbian Biochemical Society",
journal = "Proceedings - Serbian Biochemical Society, 10th Conference, Kragujevac, Serbia, 24.09.2021",
title = "Monoterpens variability in Teucrium montanum L. essential oils. Biochemical insights into molecular mechanisms",
pages = "187",
url = "https://hdl.handle.net/21.15107/rcub_cer_5020"
}

Zlatić, N., Mihailović, V., Lješević, M., Beškoski, V.,& Stanković, M.. (2021). Monoterpens variability in Teucrium montanum L. essential oils. Biochemical insights into molecular mechanisms. in Proceedings - Serbian Biochemical Society, 10th Conference, Kragujevac, Serbia, 24.09.2021
Belgrade : Faculty of Chemistry., 187.
https://hdl.handle.net/21.15107/rcub_cer_5020

Zlatić N, Mihailović V, Lješević M, Beškoski V, Stanković M. Monoterpens variability in Teucrium montanum L. essential oils. Biochemical insights into molecular mechanisms. in Proceedings - Serbian Biochemical Society, 10th Conference, Kragujevac, Serbia, 24.09.2021. 2021;:187.
https://hdl.handle.net/21.15107/rcub_cer_5020 .

Zlatić, Nenad, Mihailović, Vladimir, Lješević, Marija, Beškoski, Vladimir, Stanković, Milan, "Monoterpens variability in Teucrium montanum L. essential oils. Biochemical insights into molecular mechanisms" in Proceedings - Serbian Biochemical Society, 10th Conference, Kragujevac, Serbia, 24.09.2021 (2021):187,
https://hdl.handle.net/21.15107/rcub_cer_5020 .

Petrović, M. M., Roschger, C., Chaudary, S., Zierer, A., Mladenović, M., Marković, V., Trifunović, S. S.,& Joksović, M. D.. (2021). Low cytotoxic quinoline-4-carboxylic acids derived from vanillin precursors as potential human dihydroorotate dehydrogenase inhibitors. in Bioorganic & Medicinal Chemistry Letters
Elsevier., 46.
https://doi.org/10.1016/j.bmcl.2021.128194

Petrović MM, Roschger C, Chaudary S, Zierer A, Mladenović M, Marković V, Trifunović SS, Joksović MD. Low cytotoxic quinoline-4-carboxylic acids derived from vanillin precursors as potential human dihydroorotate dehydrogenase inhibitors. in Bioorganic & Medicinal Chemistry Letters. 2021;46.
doi:10.1016/j.bmcl.2021.128194 .

Petrović, Milena M., Roschger, Cornelia, Chaudary, Sidrah, Zierer, Andreas, Mladenović, Milan, Marković, Violeta, Trifunović, Snežana S., Joksović, Milan D., "Low cytotoxic quinoline-4-carboxylic acids derived from vanillin precursors as potential human dihydroorotate dehydrogenase inhibitors" in Bioorganic & Medicinal Chemistry Letters, 46 (2021),
https://doi.org/10.1016/j.bmcl.2021.128194 . .

TY  - DATA
AU  - Petrović, Milena M.
AU  - Roschger, Cornelia
AU  - Chaudary, Sidrah
AU  - Zierer, Andreas
AU  - Mladenović, Milan
AU  - Marković, Violeta
AU  - Trifunović, Snežana S.
AU  - Joksović, Milan D.
PY  - 2021
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4551
PB  - Elsevier
T2  - Bioorganic & Medicinal Chemistry Letters
T1  - Supplementary data for the article: Petrović, M. M.; Roschger, C.; Chaudary, S.; Zierer, A.; Mladenović, M.; Marković, V.; Trifunović, S.; Joksović, M. D. Low Cytotoxic Quinoline-4-Carboxylic Acids Derived from Vanillin Precursors as Potential Human Dihydroorotate Dehydrogenase Inhibitors. Bioorganic & Medicinal Chemistry Letters 2021, 46, 128194. https://doi.org/10.1016/j.bmcl.2021.128194.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4551
ER  - 

@misc{
author = "Petrović, Milena M. and Roschger, Cornelia and Chaudary, Sidrah and Zierer, Andreas and Mladenović, Milan and Marković, Violeta and Trifunović, Snežana S. and Joksović, Milan D.",
year = "2021",
publisher = "Elsevier",
journal = "Bioorganic & Medicinal Chemistry Letters",
title = "Supplementary data for the article: Petrović, M. M.; Roschger, C.; Chaudary, S.; Zierer, A.; Mladenović, M.; Marković, V.; Trifunović, S.; Joksović, M. D. Low Cytotoxic Quinoline-4-Carboxylic Acids Derived from Vanillin Precursors as Potential Human Dihydroorotate Dehydrogenase Inhibitors. Bioorganic & Medicinal Chemistry Letters 2021, 46, 128194. https://doi.org/10.1016/j.bmcl.2021.128194.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4551"
}

Petrović, M. M., Roschger, C., Chaudary, S., Zierer, A., Mladenović, M., Marković, V., Trifunović, S. S.,& Joksović, M. D.. (2021). Supplementary data for the article: Petrović, M. M.; Roschger, C.; Chaudary, S.; Zierer, A.; Mladenović, M.; Marković, V.; Trifunović, S.; Joksović, M. D. Low Cytotoxic Quinoline-4-Carboxylic Acids Derived from Vanillin Precursors as Potential Human Dihydroorotate Dehydrogenase Inhibitors. Bioorganic & Medicinal Chemistry Letters 2021, 46, 128194. https://doi.org/10.1016/j.bmcl.2021.128194.. in Bioorganic & Medicinal Chemistry Letters
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4551

Petrović MM, Roschger C, Chaudary S, Zierer A, Mladenović M, Marković V, Trifunović SS, Joksović MD. Supplementary data for the article: Petrović, M. M.; Roschger, C.; Chaudary, S.; Zierer, A.; Mladenović, M.; Marković, V.; Trifunović, S.; Joksović, M. D. Low Cytotoxic Quinoline-4-Carboxylic Acids Derived from Vanillin Precursors as Potential Human Dihydroorotate Dehydrogenase Inhibitors. Bioorganic & Medicinal Chemistry Letters 2021, 46, 128194. https://doi.org/10.1016/j.bmcl.2021.128194.. in Bioorganic & Medicinal Chemistry Letters. 2021;.
https://hdl.handle.net/21.15107/rcub_cherry_4551 .

Petrović, Milena M., Roschger, Cornelia, Chaudary, Sidrah, Zierer, Andreas, Mladenović, Milan, Marković, Violeta, Trifunović, Snežana S., Joksović, Milan D., "Supplementary data for the article: Petrović, M. M.; Roschger, C.; Chaudary, S.; Zierer, A.; Mladenović, M.; Marković, V.; Trifunović, S.; Joksović, M. D. Low Cytotoxic Quinoline-4-Carboxylic Acids Derived from Vanillin Precursors as Potential Human Dihydroorotate Dehydrogenase Inhibitors. Bioorganic & Medicinal Chemistry Letters 2021, 46, 128194. https://doi.org/10.1016/j.bmcl.2021.128194." in Bioorganic & Medicinal Chemistry Letters (2021),
https://hdl.handle.net/21.15107/rcub_cherry_4551 .

TY  - CONF
AU  - Zlatić, Nenad
AU  - Mihailović, V.
AU  - Đelić, Gorica
AU  - Lješević, Marija
AU  - Beškoski, Vladimir
AU  - Stanković, M.
PY  - 2021
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5241
AB  - Cilj prikazanog istraživanja je utvrđivanje kvalitativne varijabilnosti i relativne zastupljenosti seskviterpenskih ugljovodonika u uzorcima vrste Teucrium montanum L. prikupljenih sa dva različita tipa podloge. Četiri uzorka etarskih ulja sa serpentinita i četiri sa krečnjaka dobijeno je metodom hidrodestilacije od nadzemnihbiljnih delova. Na osnovu rezultata, pokazano je da populacije sa serpentinitskih staništa sintetišu 2 puta više seskviterpena nego sa krečnjačkih, dok je jedinjenje 6-epi-β-kubeben detektovan samo u populacijama sa krečnjaka. Edafske karakteristikestaništa utiču na kvalitativni sastav i relativnu zastupljenost seskviterpena u etarskim uljima što ima značajnu primenu u biotehnologiji.
AB  - The aim of this study is to determine the qualitative variability and relative presence of sesquiterpene hydrocarbons in essential oils samples of Teucrium montanum L. collected from two different substrate types. Four samples of essential oils from serpentinite and four from calcareous were obtained by the method of hydrodistillation from aboveground plant parts. Based on the results, it was shown that populations from serpentinite habitats synthesize 2 times more sesquiterpenes than from calcareous ones, while the compound 6-epi-β-cubeben was detected only in populations from calcareous. Edaphic characteristics of habitats affect the qualitative composition and relative presence of sesquiterpenes in essential oils, which has a significant application in biotechnology.
PB  - Čačak, Srbija : Univerzitet u Kragujevcu, Agronomski fakultet u Čačku
C3  - XXVI Savetovanje o biotehnologiji, Zbornik Radova 453-458, Čačak, Srbija, 12-13 Mart 2021
T1  - Varijabilnost seskviterpena etarskih ulja vrste Teucrium montanum l.
T1  - Variability of sesquiterpenes in essential oils of the species Teucrium montanum l.
SP  - 453
EP  - 458
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5241
ER  - 

@conference{
author = "Zlatić, Nenad and Mihailović, V. and Đelić, Gorica and Lješević, Marija and Beškoski, Vladimir and Stanković, M.",
year = "2021",
abstract = "Cilj prikazanog istraživanja je utvrđivanje kvalitativne varijabilnosti i relativne zastupljenosti seskviterpenskih ugljovodonika u uzorcima vrste Teucrium montanum L. prikupljenih sa dva različita tipa podloge. Četiri uzorka etarskih ulja sa serpentinita i četiri sa krečnjaka dobijeno je metodom hidrodestilacije od nadzemnihbiljnih delova. Na osnovu rezultata, pokazano je da populacije sa serpentinitskih staništa sintetišu 2 puta više seskviterpena nego sa krečnjačkih, dok je jedinjenje 6-epi-β-kubeben detektovan samo u populacijama sa krečnjaka. Edafske karakteristikestaništa utiču na kvalitativni sastav i relativnu zastupljenost seskviterpena u etarskim uljima što ima značajnu primenu u biotehnologiji., The aim of this study is to determine the qualitative variability and relative presence of sesquiterpene hydrocarbons in essential oils samples of Teucrium montanum L. collected from two different substrate types. Four samples of essential oils from serpentinite and four from calcareous were obtained by the method of hydrodistillation from aboveground plant parts. Based on the results, it was shown that populations from serpentinite habitats synthesize 2 times more sesquiterpenes than from calcareous ones, while the compound 6-epi-β-cubeben was detected only in populations from calcareous. Edaphic characteristics of habitats affect the qualitative composition and relative presence of sesquiterpenes in essential oils, which has a significant application in biotechnology.",
publisher = "Čačak, Srbija : Univerzitet u Kragujevcu, Agronomski fakultet u Čačku",
journal = "XXVI Savetovanje o biotehnologiji, Zbornik Radova 453-458, Čačak, Srbija, 12-13 Mart 2021",
title = "Varijabilnost seskviterpena etarskih ulja vrste Teucrium montanum l., Variability of sesquiterpenes in essential oils of the species Teucrium montanum l.",
pages = "453-458",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5241"
}

Zlatić, N., Mihailović, V., Đelić, G., Lješević, M., Beškoski, V.,& Stanković, M.. (2021). Varijabilnost seskviterpena etarskih ulja vrste Teucrium montanum l.. in XXVI Savetovanje o biotehnologiji, Zbornik Radova 453-458, Čačak, Srbija, 12-13 Mart 2021
Čačak, Srbija : Univerzitet u Kragujevcu, Agronomski fakultet u Čačku., 453-458.
https://hdl.handle.net/21.15107/rcub_cherry_5241

Zlatić N, Mihailović V, Đelić G, Lješević M, Beškoski V, Stanković M. Varijabilnost seskviterpena etarskih ulja vrste Teucrium montanum l.. in XXVI Savetovanje o biotehnologiji, Zbornik Radova 453-458, Čačak, Srbija, 12-13 Mart 2021. 2021;:453-458.
https://hdl.handle.net/21.15107/rcub_cherry_5241 .

Zlatić, Nenad, Mihailović, V., Đelić, Gorica, Lješević, Marija, Beškoski, Vladimir, Stanković, M., "Varijabilnost seskviterpena etarskih ulja vrste Teucrium montanum l." in XXVI Savetovanje o biotehnologiji, Zbornik Radova 453-458, Čačak, Srbija, 12-13 Mart 2021 (2021):453-458,
https://hdl.handle.net/21.15107/rcub_cherry_5241 .