TY  - JOUR
AU  - Dinić, Jelena
AU  - Podolski-Renić, Ana
AU  - Jeremić, Marko
AU  - Pešić, Milica
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3750
AB  - Medicinal value of natural products comes from symbiotic and competitive evolution in Earth’s complex biosphere. Billions of years of co-evolutionary interactions among millions of species have produced a large repertoire of defense molecules effective in fighting bacteria, viral, and fungal pathogens. Each species contains millions of different and useful molecules and new research technologies enabled the screening of molecules and complex mixtures from diverse biological sources. Traditional use of plants and other species led to the discovery of many bioactive compounds with various properties. In the last four decades, a large number of them were evaluated for their potential to treat cancer. Penetration of drugs into the cancer cell is necessary for their lethal pharmacological effect through interaction with intracellular target molecules. Increased activity of membrane efflux pumps reduces the intracellular drug accumulation, thereby preventing drug-target interactions. The discovery of the efflux transporter P-glycoprotein (P-gp) in multidrug resistant (MDR) cancer cells prompted the efforts in overcoming drug resistance by P-gp inhibition. The search for nontoxic anticancer agents from natural sources able to overcome MDR has been imperative in the field of drug design and discovery. Herein, we review various natural compounds from diverse sources emphasizing their potential to inhibit P-gp activity and/or expression.
PB  - Bentham Science Publishers B.V.
T2  - Current Pharmaceutical Design
T1  - Potential of natural-based anticancer compounds for P-glycoprotein inhibition
VL  - 24
IS  - 36
SP  - 4334
EP  - 4354
DO  - 10.2174/1381612825666190112164211
ER  - 

@article{
author = "Dinić, Jelena and Podolski-Renić, Ana and Jeremić, Marko and Pešić, Milica",
year = "2018",
abstract = "Medicinal value of natural products comes from symbiotic and competitive evolution in Earth’s complex biosphere. Billions of years of co-evolutionary interactions among millions of species have produced a large repertoire of defense molecules effective in fighting bacteria, viral, and fungal pathogens. Each species contains millions of different and useful molecules and new research technologies enabled the screening of molecules and complex mixtures from diverse biological sources. Traditional use of plants and other species led to the discovery of many bioactive compounds with various properties. In the last four decades, a large number of them were evaluated for their potential to treat cancer. Penetration of drugs into the cancer cell is necessary for their lethal pharmacological effect through interaction with intracellular target molecules. Increased activity of membrane efflux pumps reduces the intracellular drug accumulation, thereby preventing drug-target interactions. The discovery of the efflux transporter P-glycoprotein (P-gp) in multidrug resistant (MDR) cancer cells prompted the efforts in overcoming drug resistance by P-gp inhibition. The search for nontoxic anticancer agents from natural sources able to overcome MDR has been imperative in the field of drug design and discovery. Herein, we review various natural compounds from diverse sources emphasizing their potential to inhibit P-gp activity and/or expression.",
publisher = "Bentham Science Publishers B.V.",
journal = "Current Pharmaceutical Design",
title = "Potential of natural-based anticancer compounds for P-glycoprotein inhibition",
volume = "24",
number = "36",
pages = "4334-4354",
doi = "10.2174/1381612825666190112164211"
}

Dinić, J., Podolski-Renić, A., Jeremić, M.,& Pešić, M.. (2018). Potential of natural-based anticancer compounds for P-glycoprotein inhibition. in Current Pharmaceutical Design
Bentham Science Publishers B.V.., 24(36), 4334-4354.
https://doi.org/10.2174/1381612825666190112164211

Dinić J, Podolski-Renić A, Jeremić M, Pešić M. Potential of natural-based anticancer compounds for P-glycoprotein inhibition. in Current Pharmaceutical Design. 2018;24(36):4334-4354.
doi:10.2174/1381612825666190112164211 .

Dinić, Jelena, Podolski-Renić, Ana, Jeremić, Marko, Pešić, Milica, "Potential of natural-based anticancer compounds for P-glycoprotein inhibition" in Current Pharmaceutical Design, 24, no. 36 (2018):4334-4354,
https://doi.org/10.2174/1381612825666190112164211 . .