Farmakodinamska i farmakogenetska istraživanja novih lekova i prediktivna/prognostička vrednost farmakoterapije u onkologiji

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Farmakodinamska i farmakogenetska istraživanja novih lekova i prediktivna/prognostička vrednost farmakoterapije u onkologiji (en)
Фармакодинамска и фармакогенетска истраживања нових лекова и предиктивна/прогностичка вредност фармакотерапије у онкологији (sr)
Farmakodinamska i farmakogenetska istraživanja novih lekova i prediktivna/prognostička vrednost farmakoterapije u onkologiji (sr_RS)
Authors

Publications

X-Ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex

Ivanovic, Ivanka; Grgurić-Šipka, Sanja; Gligorijević, Nevenka; Radulović, Siniša; Roller, Alexander; Tešić, Živoslav Lj.; Keppler, Bernhard K.

(Serbian Chemical Soc, Belgrade, 2011)

TY  - JOUR
AU  - Ivanovic, Ivanka
AU  - Grgurić-Šipka, Sanja
AU  - Gligorijević, Nevenka
AU  - Radulović, Siniša
AU  - Roller, Alexander
AU  - Tešić, Živoslav Lj.
AU  - Keppler, Bernhard K.
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1149
AB  - A ruthenium(II)-arene complex with picolinic acid, [(eta(6)-p-cymene)RuCl(pico)]center dot H(2)O, was prepared by the reaction of [(eta(6)-p-cymene)RuCl(2)](2) with picolinic acid in a 1:2 molar ratio in 2-propanol. The compound was characterized by elemental analysis, and IR and NMR spectroscopy. X-ray diffraction analysis showed that the molecule adopts a "three-leg piano-stool" geometry, which is common for this type of complexes. The cytotoxic activity of the complex was tested in two human cancer cell lines HeLa (cervix) and FemX (melanoma) by MTT assay. The IC(50) values were at 82.0 and 36.2 mu mol dm(-3) for HeLa and FemX cells, respectively.
AB  - Rutenijum(II)-arenski kompleks sa pikolinskom kiselinom [(η6-p-cimen)RuCl(pikolinato)]·H2O sintetisan je u reakciji [(η6-p-cimen)RuCl2]2 kompleksa sa pikolinskom kiselinom u molskom odnosu 1:2 u izopropanolu. Jedinjenje je okarakterisano elementalnom analizom, IC i NMR spektroskopijom. Analiza difrakcijom X-zracima pokazala je da molekul ima tzv. 'three-leg piano-stool' geometriju koja je karakteristična za ovaj tip kompleksa. Citotoksična aktivnost kompleksa je određena na dve humane tumorske ćelijske linije, HeLa (grlića materice) i FemX (melanoma), MTT testom. IC50 vrednosti su bile 82,0 i 36,2 µmol dm-3 za HeLa i FemX ćelije, redom.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - X-Ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex
T1  - Rendgenska strukturna analiza i citotoksična aktivnost pikolinato rutenijum(II)-arenskog kompleksa
VL  - 76
IS  - 1
SP  - 53
EP  - 61
DO  - 10.2298/JSC100517017I
UR  - Kon_2149
ER  - 
@article{
author = "Ivanovic, Ivanka and Grgurić-Šipka, Sanja and Gligorijević, Nevenka and Radulović, Siniša and Roller, Alexander and Tešić, Živoslav Lj. and Keppler, Bernhard K.",
year = "2011",
abstract = "A ruthenium(II)-arene complex with picolinic acid, [(eta(6)-p-cymene)RuCl(pico)]center dot H(2)O, was prepared by the reaction of [(eta(6)-p-cymene)RuCl(2)](2) with picolinic acid in a 1:2 molar ratio in 2-propanol. The compound was characterized by elemental analysis, and IR and NMR spectroscopy. X-ray diffraction analysis showed that the molecule adopts a "three-leg piano-stool" geometry, which is common for this type of complexes. The cytotoxic activity of the complex was tested in two human cancer cell lines HeLa (cervix) and FemX (melanoma) by MTT assay. The IC(50) values were at 82.0 and 36.2 mu mol dm(-3) for HeLa and FemX cells, respectively., Rutenijum(II)-arenski kompleks sa pikolinskom kiselinom [(η6-p-cimen)RuCl(pikolinato)]·H2O sintetisan je u reakciji [(η6-p-cimen)RuCl2]2 kompleksa sa pikolinskom kiselinom u molskom odnosu 1:2 u izopropanolu. Jedinjenje je okarakterisano elementalnom analizom, IC i NMR spektroskopijom. Analiza difrakcijom X-zracima pokazala je da molekul ima tzv. 'three-leg piano-stool' geometriju koja je karakteristična za ovaj tip kompleksa. Citotoksična aktivnost kompleksa je određena na dve humane tumorske ćelijske linije, HeLa (grlića materice) i FemX (melanoma), MTT testom. IC50 vrednosti su bile 82,0 i 36,2 µmol dm-3 za HeLa i FemX ćelije, redom.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "X-Ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex, Rendgenska strukturna analiza i citotoksična aktivnost pikolinato rutenijum(II)-arenskog kompleksa",
volume = "76",
number = "1",
pages = "53-61",
doi = "10.2298/JSC100517017I",
url = "Kon_2149"
}
Ivanovic, I., Grgurić-Šipka, S., Gligorijević, N., Radulović, S., Roller, A., Tešić, Ž. Lj.,& Keppler, B. K.. (2011). X-Ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 76(1), 53-61.
https://doi.org/10.2298/JSC100517017I
Kon_2149
Ivanovic I, Grgurić-Šipka S, Gligorijević N, Radulović S, Roller A, Tešić ŽL, Keppler BK. X-Ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex. in Journal of the Serbian Chemical Society. 2011;76(1):53-61.
doi:10.2298/JSC100517017I
Kon_2149 .
Ivanovic, Ivanka, Grgurić-Šipka, Sanja, Gligorijević, Nevenka, Radulović, Siniša, Roller, Alexander, Tešić, Živoslav Lj., Keppler, Bernhard K., "X-Ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex" in Journal of the Serbian Chemical Society, 76, no. 1 (2011):53-61,
https://doi.org/10.2298/JSC100517017I .,
Kon_2149 .
18
17
19

A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide

Vujčić, Miroslava; Lazić, Milan; Milenković, Milica R.; Sladić, Dušan; Radulović, Siniša; Filipović, Nenad R.; Anđelković, Katarina K.

(Wiley-Blackwell, Malden, 2011)

TY  - JOUR
AU  - Vujčić, Miroslava
AU  - Lazić, Milan
AU  - Milenković, Milica R.
AU  - Sladić, Dušan
AU  - Radulović, Siniša
AU  - Filipović, Nenad R.
AU  - Anđelković, Katarina K.
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1168
AB  - Organometallic Cd(II) compounds have recently attracted attention for their anticancer activity. The interaction of the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2pyridyl) ethylidene] propanedihydrazide (Cd(II)H(2)L), with calf thymus DNA (CT-DNA) was monitored by blue shift in UV-vis spectra of the complex. The binding constant of Cd(II) H2L complex with CT-DNA was determined (K(B) = 1.8 x 10(4) M(-1)) and was indicative of minor groove binding. Agarose gel electrophoretic changes in mobility of supercoiled and circular forms of pBR322 and pUC18 plasmids in the presence of the complex suggest that conformational changes in the plasmids occur upon binding of the Cd(II) H2L complex. The Cd(II) H2L complex induced perturbation of the cell cycle phase distribution and an increase in the percentage of cells in the sub-G1 phase of human cervical cancer HeLa cell line and murine melanoma B16 cell line. Immunoblotting analysis showed the overexpression of Bcl-2 protein with the Cd(II)H(2)L complex. (C) 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25: 175-182, 2011; View this article online at wileyonlinelibrary.com. DOI 10:1002/jbt.20374
PB  - Wiley-Blackwell, Malden
T2  - Journal of Biochemical and Molecular Toxicology
T1  - A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide
VL  - 25
IS  - 3
SP  - 175
EP  - 182
DO  - 10.1002/jbt.20374
UR  - Kon_2190
ER  - 
@article{
author = "Vujčić, Miroslava and Lazić, Milan and Milenković, Milica R. and Sladić, Dušan and Radulović, Siniša and Filipović, Nenad R. and Anđelković, Katarina K.",
year = "2011",
abstract = "Organometallic Cd(II) compounds have recently attracted attention for their anticancer activity. The interaction of the dinuclear complex of Cd(II) with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2pyridyl) ethylidene] propanedihydrazide (Cd(II)H(2)L), with calf thymus DNA (CT-DNA) was monitored by blue shift in UV-vis spectra of the complex. The binding constant of Cd(II) H2L complex with CT-DNA was determined (K(B) = 1.8 x 10(4) M(-1)) and was indicative of minor groove binding. Agarose gel electrophoretic changes in mobility of supercoiled and circular forms of pBR322 and pUC18 plasmids in the presence of the complex suggest that conformational changes in the plasmids occur upon binding of the Cd(II) H2L complex. The Cd(II) H2L complex induced perturbation of the cell cycle phase distribution and an increase in the percentage of cells in the sub-G1 phase of human cervical cancer HeLa cell line and murine melanoma B16 cell line. Immunoblotting analysis showed the overexpression of Bcl-2 protein with the Cd(II)H(2)L complex. (C) 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25: 175-182, 2011; View this article online at wileyonlinelibrary.com. DOI 10:1002/jbt.20374",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Biochemical and Molecular Toxicology",
title = "A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide",
volume = "25",
number = "3",
pages = "175-182",
doi = "10.1002/jbt.20374",
url = "Kon_2190"
}
Vujčić, M., Lazić, M., Milenković, M. R., Sladić, D., Radulović, S., Filipović, N. R.,& Anđelković, K. K.. (2011). A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide. in Journal of Biochemical and Molecular Toxicology
Wiley-Blackwell, Malden., 25(3), 175-182.
https://doi.org/10.1002/jbt.20374
Kon_2190
Vujčić M, Lazić M, Milenković MR, Sladić D, Radulović S, Filipović NR, Anđelković KK. A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide. in Journal of Biochemical and Molecular Toxicology. 2011;25(3):175-182.
doi:10.1002/jbt.20374
Kon_2190 .
Vujčić, Miroslava, Lazić, Milan, Milenković, Milica R., Sladić, Dušan, Radulović, Siniša, Filipović, Nenad R., Anđelković, Katarina K., "A Comparative Study of DNA Binding and Cell Cycle Phase Perturbation by the Dinuclear Complex of Cd(II) with the Condensation Product of 2-Acetylpyridine and Malonic Acid Dihydrazide N ',N ' 2-bis[(1E)-1-(2-pyridyl) ethylidene] propanedihydrazide" in Journal of Biochemical and Molecular Toxicology, 25, no. 3 (2011):175-182,
https://doi.org/10.1002/jbt.20374 .,
Kon_2190 .
15
13
16

Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes

Bjelogrlić, Snežana K.; Todorović, Tamara; Bacchi, Alessia; Zec, Manja; Sladić, Dušan; Srdić-Rajić, Tatjana; Radanović, Dušanka D.; Radulović, Siniša; Pelizzi, Giancarlo; Anđelković, Katarina K.

(Elsevier Science Inc, New York, 2010)

TY  - JOUR
AU  - Bjelogrlić, Snežana K.
AU  - Todorović, Tamara
AU  - Bacchi, Alessia
AU  - Zec, Manja
AU  - Sladić, Dušan
AU  - Srdić-Rajić, Tatjana
AU  - Radanović, Dušanka D.
AU  - Radulović, Siniša
AU  - Pelizzi, Giancarlo
AU  - Anđelković, Katarina K.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1081
AB  - Two novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide were synthesized. The structure of Cd(II) complex was determined by X-ray crystallography. The ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms and the selenium donor. The cadmium ion completes its five-coordination by two chloride ligands, forming a square-pyramidal geometry. The structure of Zn(II) complex was established by analysis of spectroscopic data, which indicated coordination of the ligand as a bidentate via the selenium and the azomethine nitrogen atoms. The cytotoxic activity of the newly synthesized complexes, as well as if five structurally related complexes and the ligand evaluated against eight tumor cell lines. The new Cd(II) complex showed the highest activity similar to cisplatin with IC50 less than 10 mu M for all cell lines. Cell cycle distribution and apoptosis study showed that Cd(II) complex and cisplatin might have some similarity in anticancer activity, which was not the case for cisplatin and other studied complexes. Effects of the complexes on matrix metalloproteinases (MMPs) MMP-9 and MMP-2 was also studied. Cd(II) and Zn(II) complexes and cisplatin increased MMP-2 activity in supernatants of tested cells. while Ni(II) complex with the same ligand decreased the activity, implying a possible activity in preventing tumor invasion and metastasis processes. (C) 2010 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes
VL  - 104
IS  - 6
SP  - 673
EP  - 682
DO  - 10.1016/j.jinorgbio.2010.02.009
UR  - Kon_2081
ER  - 
@article{
author = "Bjelogrlić, Snežana K. and Todorović, Tamara and Bacchi, Alessia and Zec, Manja and Sladić, Dušan and Srdić-Rajić, Tatjana and Radanović, Dušanka D. and Radulović, Siniša and Pelizzi, Giancarlo and Anđelković, Katarina K.",
year = "2010",
abstract = "Two novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide were synthesized. The structure of Cd(II) complex was determined by X-ray crystallography. The ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms and the selenium donor. The cadmium ion completes its five-coordination by two chloride ligands, forming a square-pyramidal geometry. The structure of Zn(II) complex was established by analysis of spectroscopic data, which indicated coordination of the ligand as a bidentate via the selenium and the azomethine nitrogen atoms. The cytotoxic activity of the newly synthesized complexes, as well as if five structurally related complexes and the ligand evaluated against eight tumor cell lines. The new Cd(II) complex showed the highest activity similar to cisplatin with IC50 less than 10 mu M for all cell lines. Cell cycle distribution and apoptosis study showed that Cd(II) complex and cisplatin might have some similarity in anticancer activity, which was not the case for cisplatin and other studied complexes. Effects of the complexes on matrix metalloproteinases (MMPs) MMP-9 and MMP-2 was also studied. Cd(II) and Zn(II) complexes and cisplatin increased MMP-2 activity in supernatants of tested cells. while Ni(II) complex with the same ligand decreased the activity, implying a possible activity in preventing tumor invasion and metastasis processes. (C) 2010 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes",
volume = "104",
number = "6",
pages = "673-682",
doi = "10.1016/j.jinorgbio.2010.02.009",
url = "Kon_2081"
}
Bjelogrlić, S. K., Todorović, T., Bacchi, A., Zec, M., Sladić, D., Srdić-Rajić, T., Radanović, D. D., Radulović, S., Pelizzi, G.,& Anđelković, K. K.. (2010). Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 104(6), 673-682.
https://doi.org/10.1016/j.jinorgbio.2010.02.009
Kon_2081
Bjelogrlić SK, Todorović T, Bacchi A, Zec M, Sladić D, Srdić-Rajić T, Radanović DD, Radulović S, Pelizzi G, Anđelković KK. Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes. in Journal of Inorganic Biochemistry. 2010;104(6):673-682.
doi:10.1016/j.jinorgbio.2010.02.009
Kon_2081 .
Bjelogrlić, Snežana K., Todorović, Tamara, Bacchi, Alessia, Zec, Manja, Sladić, Dušan, Srdić-Rajić, Tatjana, Radanović, Dušanka D., Radulović, Siniša, Pelizzi, Giancarlo, Anđelković, Katarina K., "Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes" in Journal of Inorganic Biochemistry, 104, no. 6 (2010):673-682,
https://doi.org/10.1016/j.jinorgbio.2010.02.009 .,
Kon_2081 .
3
43
47
46

Cytotoxic Guaianolide from Anthemis segetalis (Asteraceae)

Vučković, Ivan M.; Vujisić, Ljubodrag V.; Stesevic, Danijela; Radulović, Siniša; Lazić, Milan; Milosavljević, Slobodan M.

(John Wiley & Sons Ltd, Chichester, 2010)

TY  - JOUR
AU  - Vučković, Ivan M.
AU  - Vujisić, Ljubodrag V.
AU  - Stesevic, Danijela
AU  - Radulović, Siniša
AU  - Lazić, Milan
AU  - Milosavljević, Slobodan M.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1048
AB  - Two epimeric guaianolides were isolated from the aerial parts of Anthemis segetalis. These compounds have not been detected in any Anthemis species so far. One of them was tested for cytotoxicity against human cervical cancer (HeLa) and murine melanoma (B16) cell lines showing appreciable activity. copyright (C) 2009 John Wiley & Sons, Ltd.
PB  - John Wiley & Sons Ltd, Chichester
T2  - Phytotherapy Research
T1  - Cytotoxic Guaianolide from Anthemis segetalis (Asteraceae)
VL  - 24
IS  - 2
SP  - 225
EP  - 227
DO  - 10.1002/ptr.2916
UR  - Kon_2048
ER  - 
@article{
author = "Vučković, Ivan M. and Vujisić, Ljubodrag V. and Stesevic, Danijela and Radulović, Siniša and Lazić, Milan and Milosavljević, Slobodan M.",
year = "2010",
abstract = "Two epimeric guaianolides were isolated from the aerial parts of Anthemis segetalis. These compounds have not been detected in any Anthemis species so far. One of them was tested for cytotoxicity against human cervical cancer (HeLa) and murine melanoma (B16) cell lines showing appreciable activity. copyright (C) 2009 John Wiley & Sons, Ltd.",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Phytotherapy Research",
title = "Cytotoxic Guaianolide from Anthemis segetalis (Asteraceae)",
volume = "24",
number = "2",
pages = "225-227",
doi = "10.1002/ptr.2916",
url = "Kon_2048"
}
Vučković, I. M., Vujisić, L. V., Stesevic, D., Radulović, S., Lazić, M.,& Milosavljević, S. M.. (2010). Cytotoxic Guaianolide from Anthemis segetalis (Asteraceae). in Phytotherapy Research
John Wiley & Sons Ltd, Chichester., 24(2), 225-227.
https://doi.org/10.1002/ptr.2916
Kon_2048
Vučković IM, Vujisić LV, Stesevic D, Radulović S, Lazić M, Milosavljević SM. Cytotoxic Guaianolide from Anthemis segetalis (Asteraceae). in Phytotherapy Research. 2010;24(2):225-227.
doi:10.1002/ptr.2916
Kon_2048 .
Vučković, Ivan M., Vujisić, Ljubodrag V., Stesevic, Danijela, Radulović, Siniša, Lazić, Milan, Milosavljević, Slobodan M., "Cytotoxic Guaianolide from Anthemis segetalis (Asteraceae)" in Phytotherapy Research, 24, no. 2 (2010):225-227,
https://doi.org/10.1002/ptr.2916 .,
Kon_2048 .
6
9
8

Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity

Grgurić-Šipka, Sanja; Ivanovic, Ivanka; Rakic, Gordana; Todorović, Nina; Gligorijević, Nevenka; Radulović, Siniša; Arion, Vladimir B.; Keppler, Bernhard K.; Tešić, Živoslav Lj.

(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2010)

TY  - JOUR
AU  - Grgurić-Šipka, Sanja
AU  - Ivanovic, Ivanka
AU  - Rakic, Gordana
AU  - Todorović, Nina
AU  - Gligorijević, Nevenka
AU  - Radulović, Siniša
AU  - Arion, Vladimir B.
AU  - Keppler, Bernhard K.
AU  - Tešić, Živoslav Lj.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1058
AB  - Ruthenium(II)-arene complexes of general formulae [(eta(6)-p-cymene)Ru(L1-3)Cl-2], where L1-3 is 3-acetylpyridine (1), 4-acetylpyridine (2) and 2-amino-5-chloropyridine (3), Correspondingly, [(eta(6)-p-cymene)Ru(HL4,5)Cl-2], where HL4 and HL5 are respectively isonicotinic acid (4) and nicotinic acid (5) and [(eta(6)-p-cymene)Ru(HL6-9)Cl], where H2L6-9 represent 2,3-pyridinedicarboxylic acid (6), 2,4-pyidinedicarboxylic acid (7), 2,5-pyridinedicarboxylic acid (8) and 2,6-pyridinedicarboxylic acid (9), were prepared by the reaction of (eta(6)-p-cymene)(2)RuCl2](2) (10) with the corresponding ligand in 1:2 molar ratio in isopropanol. The complexes were characterized by elemental analysis, mass spectrometry, IR and NMR spectroscopies. According to these data the molecules adopt the usual "three-leg piano-stool" geometry which is common for this type of complexes. The structures of I and 7 were determined by X-ray crystallography. The complexes revealed low antiproliferative activity in six investigated tumor cell lines (HeLa, B16, FemX, MDA-MB-361, MDA-MB-453 and LS-174). The reaction of 6 with 9-methyladenine was studied by H-1 NMR, H-1, H-1 COSY and H-1, H-1 NOESY spectroscopy. (C) 2009 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity
VL  - 45
IS  - 3
SP  - 1051
EP  - 1058
DO  - 10.1016/j.ejmech.2009.11.055
UR  - Kon_2058
ER  - 
@article{
author = "Grgurić-Šipka, Sanja and Ivanovic, Ivanka and Rakic, Gordana and Todorović, Nina and Gligorijević, Nevenka and Radulović, Siniša and Arion, Vladimir B. and Keppler, Bernhard K. and Tešić, Živoslav Lj.",
year = "2010",
abstract = "Ruthenium(II)-arene complexes of general formulae [(eta(6)-p-cymene)Ru(L1-3)Cl-2], where L1-3 is 3-acetylpyridine (1), 4-acetylpyridine (2) and 2-amino-5-chloropyridine (3), Correspondingly, [(eta(6)-p-cymene)Ru(HL4,5)Cl-2], where HL4 and HL5 are respectively isonicotinic acid (4) and nicotinic acid (5) and [(eta(6)-p-cymene)Ru(HL6-9)Cl], where H2L6-9 represent 2,3-pyridinedicarboxylic acid (6), 2,4-pyidinedicarboxylic acid (7), 2,5-pyridinedicarboxylic acid (8) and 2,6-pyridinedicarboxylic acid (9), were prepared by the reaction of (eta(6)-p-cymene)(2)RuCl2](2) (10) with the corresponding ligand in 1:2 molar ratio in isopropanol. The complexes were characterized by elemental analysis, mass spectrometry, IR and NMR spectroscopies. According to these data the molecules adopt the usual "three-leg piano-stool" geometry which is common for this type of complexes. The structures of I and 7 were determined by X-ray crystallography. The complexes revealed low antiproliferative activity in six investigated tumor cell lines (HeLa, B16, FemX, MDA-MB-361, MDA-MB-453 and LS-174). The reaction of 6 with 9-methyladenine was studied by H-1 NMR, H-1, H-1 COSY and H-1, H-1 NOESY spectroscopy. (C) 2009 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity",
volume = "45",
number = "3",
pages = "1051-1058",
doi = "10.1016/j.ejmech.2009.11.055",
url = "Kon_2058"
}
Grgurić-Šipka, S., Ivanovic, I., Rakic, G., Todorović, N., Gligorijević, N., Radulović, S., Arion, V. B., Keppler, B. K.,& Tešić, Ž. Lj.. (2010). Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 45(3), 1051-1058.
https://doi.org/10.1016/j.ejmech.2009.11.055
Kon_2058
Grgurić-Šipka S, Ivanovic I, Rakic G, Todorović N, Gligorijević N, Radulović S, Arion VB, Keppler BK, Tešić ŽL. Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity. in European Journal of Medicinal Chemistry. 2010;45(3):1051-1058.
doi:10.1016/j.ejmech.2009.11.055
Kon_2058 .
Grgurić-Šipka, Sanja, Ivanovic, Ivanka, Rakic, Gordana, Todorović, Nina, Gligorijević, Nevenka, Radulović, Siniša, Arion, Vladimir B., Keppler, Bernhard K., Tešić, Živoslav Lj., "Ruthenium(II)-arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity" in European Journal of Medicinal Chemistry, 45, no. 3 (2010):1051-1058,
https://doi.org/10.1016/j.ejmech.2009.11.055 .,
Kon_2058 .
67
67
69

Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity

Rakic, Gordana M.; Grgurić-Šipka, Sanja; Kaluđerović, Goran N.; Gomez-Ruiz, Santiago; Bjelogrlić, Snežana K.; Radulović, Siniša; Tešić, Živoslav Lj.

(Elsevier France-Editions Scientifiques Medicales Elsevier, Paris, 2009)

TY  - JOUR
AU  - Rakic, Gordana M.
AU  - Grgurić-Šipka, Sanja
AU  - Kaluđerović, Goran N.
AU  - Gomez-Ruiz, Santiago
AU  - Bjelogrlić, Snežana K.
AU  - Radulović, Siniša
AU  - Tešić, Živoslav Lj.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/630
AB  - Novel complexes of platinum(II) with 3- (1) or 4-acetylpyridine (2) have been synthesized and characterized by elemental analyses, IR, H-1 and C-13 NMR spectroscopy. Single crystal X-ray diffraction revealed the trans geometry of complex 2. DFT calculations confirm formation of trans isomers for both complexes. The complexes have been tested for their cytotoxicity against HeLa (human cervical cancer), U2OS (human osteosarcoma), U2OScisR (human osteosarcoma cisplatin resistant), B16 (murine melanoma), MDA-453, MDA-361, and MCF-7 (human breast cancer), LS-174 (human colon cancer) and Femx (human melanoma) cell lines. The most promising compound trans-dichloridobis(4-acetylpyridine)platinum(II) (2) overcomes cisplatin resistance of U2OScisR cells after 48 h of drug exposure. (C) 2008 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2  - European Journal of Medicinal Chemistry
T1  - Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity
VL  - 44
IS  - 5
SP  - 1921
EP  - 1925
DO  - 10.1016/j.ejmech.2008.11.004
UR  - Kon_1979
ER  - 
@article{
author = "Rakic, Gordana M. and Grgurić-Šipka, Sanja and Kaluđerović, Goran N. and Gomez-Ruiz, Santiago and Bjelogrlić, Snežana K. and Radulović, Siniša and Tešić, Živoslav Lj.",
year = "2009",
abstract = "Novel complexes of platinum(II) with 3- (1) or 4-acetylpyridine (2) have been synthesized and characterized by elemental analyses, IR, H-1 and C-13 NMR spectroscopy. Single crystal X-ray diffraction revealed the trans geometry of complex 2. DFT calculations confirm formation of trans isomers for both complexes. The complexes have been tested for their cytotoxicity against HeLa (human cervical cancer), U2OS (human osteosarcoma), U2OScisR (human osteosarcoma cisplatin resistant), B16 (murine melanoma), MDA-453, MDA-361, and MCF-7 (human breast cancer), LS-174 (human colon cancer) and Femx (human melanoma) cell lines. The most promising compound trans-dichloridobis(4-acetylpyridine)platinum(II) (2) overcomes cisplatin resistance of U2OScisR cells after 48 h of drug exposure. (C) 2008 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "European Journal of Medicinal Chemistry",
title = "Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity",
volume = "44",
number = "5",
pages = "1921-1925",
doi = "10.1016/j.ejmech.2008.11.004",
url = "Kon_1979"
}
Rakic, G. M., Grgurić-Šipka, S., Kaluđerović, G. N., Gomez-Ruiz, S., Bjelogrlić, S. K., Radulović, S.,& Tešić, Ž. Lj.. (2009). Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 44(5), 1921-1925.
https://doi.org/10.1016/j.ejmech.2008.11.004
Kon_1979
Rakic GM, Grgurić-Šipka S, Kaluđerović GN, Gomez-Ruiz S, Bjelogrlić SK, Radulović S, Tešić ŽL. Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity. in European Journal of Medicinal Chemistry. 2009;44(5):1921-1925.
doi:10.1016/j.ejmech.2008.11.004
Kon_1979 .
Rakic, Gordana M., Grgurić-Šipka, Sanja, Kaluđerović, Goran N., Gomez-Ruiz, Santiago, Bjelogrlić, Snežana K., Radulović, Siniša, Tešić, Živoslav Lj., "Novel trans-dichloridoplatinum(II) complexes with 3-and 4-acetylpyridine: Synthesis, characterization, DFT calculations and cytotoxicity" in European Journal of Medicinal Chemistry, 44, no. 5 (2009):1921-1925,
https://doi.org/10.1016/j.ejmech.2008.11.004 .,
Kon_1979 .
19
22
23

Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones

Gligorijević, Nevenka; Todorović, Tamara; Radulović, Siniša; Sladić, Dušan; Filipović, Nenad R.; Gođevac, Dejan; Jeremić, Dejan; Anđelković, Katarina K.

(Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux, 2009)

TY  - JOUR
AU  - Gligorijević, Nevenka
AU  - Todorović, Tamara
AU  - Radulović, Siniša
AU  - Sladić, Dušan
AU  - Filipović, Nenad R.
AU  - Gođevac, Dejan
AU  - Jeremić, Dejan
AU  - Anđelković, Katarina K.
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/625
AB  - New complexes of Pt(II) and Pd(II) with 2-quinolinecarboxaldehyde selenosemicarbazone were synthesized and characterized by elemental analysis, NMR and IR spectroscopy and molar conductivity measurements. The assumed geometry of Pt(II) and Pd(II) complexes was square planar where the ligand was tridentately coordinated via the quinoline and imine nitrogen atoms and the selenium atom. The cytotoxic activity of the new Pt(II) and Pd(II) compounds, as well as of some previously synthesized Cd(II), Zn(II) and Ni(II) complexes with the same or analogous ligand, was tested against a panel of three human cancer cell lines: human cervix carcinoma cells (HeLa), human melanoma cells (FemX) and breast cancer cells (MDA-361). All investigated compounds, except Pt(II) complex, possess a strong dose-dependent cytotoxic activity of the same order of magnitude as cisplatin (CDDP). The investigation of potential of these compounds to induce HeLa cell cycle perturbations was also evaluated. (c) 2008 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
T2  - European Journal of Medicinal Chemistry
T1  - Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones
VL  - 44
IS  - 4
SP  - 1623
EP  - 1629
DO  - 10.1016/j.ejmech.2008.07.033
UR  - Kon_1974
ER  - 
@article{
author = "Gligorijević, Nevenka and Todorović, Tamara and Radulović, Siniša and Sladić, Dušan and Filipović, Nenad R. and Gođevac, Dejan and Jeremić, Dejan and Anđelković, Katarina K.",
year = "2009",
abstract = "New complexes of Pt(II) and Pd(II) with 2-quinolinecarboxaldehyde selenosemicarbazone were synthesized and characterized by elemental analysis, NMR and IR spectroscopy and molar conductivity measurements. The assumed geometry of Pt(II) and Pd(II) complexes was square planar where the ligand was tridentately coordinated via the quinoline and imine nitrogen atoms and the selenium atom. The cytotoxic activity of the new Pt(II) and Pd(II) compounds, as well as of some previously synthesized Cd(II), Zn(II) and Ni(II) complexes with the same or analogous ligand, was tested against a panel of three human cancer cell lines: human cervix carcinoma cells (HeLa), human melanoma cells (FemX) and breast cancer cells (MDA-361). All investigated compounds, except Pt(II) complex, possess a strong dose-dependent cytotoxic activity of the same order of magnitude as cisplatin (CDDP). The investigation of potential of these compounds to induce HeLa cell cycle perturbations was also evaluated. (c) 2008 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux",
journal = "European Journal of Medicinal Chemistry",
title = "Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones",
volume = "44",
number = "4",
pages = "1623-1629",
doi = "10.1016/j.ejmech.2008.07.033",
url = "Kon_1974"
}
Gligorijević, N., Todorović, T., Radulović, S., Sladić, D., Filipović, N. R., Gođevac, D., Jeremić, D.,& Anđelković, K. K.. (2009). Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 44(4), 1623-1629.
https://doi.org/10.1016/j.ejmech.2008.07.033
Kon_1974
Gligorijević N, Todorović T, Radulović S, Sladić D, Filipović NR, Gođevac D, Jeremić D, Anđelković KK. Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones. in European Journal of Medicinal Chemistry. 2009;44(4):1623-1629.
doi:10.1016/j.ejmech.2008.07.033
Kon_1974 .
Gligorijević, Nevenka, Todorović, Tamara, Radulović, Siniša, Sladić, Dušan, Filipović, Nenad R., Gođevac, Dejan, Jeremić, Dejan, Anđelković, Katarina K., "Synthesis and characterization of new Pt(II) and Pd(II) complexes with 2-quinolinecarboxaldehyde selenosemicarbazone: Cytotoxic activity evaluation of Cd(II), Zn(II), Ni(II), Pt(II) and Pd(II) complexes with heteroaromatic selenosemicarbazones" in European Journal of Medicinal Chemistry, 44, no. 4 (2009):1623-1629,
https://doi.org/10.1016/j.ejmech.2008.07.033 .,
Kon_1974 .
43
48
44

Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes

Malesevic, Nevenka; Srdić, Tatjana; Radulović, Siniša; Sladić, Dušan; Radulovic, Vesna; Brčeski, Ilija; Anđelković, Katarina K.

(Elsevier Science Inc, New York, 2006)

TY  - JOUR
AU  - Malesevic, Nevenka
AU  - Srdić, Tatjana
AU  - Radulović, Siniša
AU  - Sladić, Dušan
AU  - Radulovic, Vesna
AU  - Brčeski, Ilija
AU  - Anđelković, Katarina K.
PY  - 2006
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/762
AB  - A new palladium(II) complex I of the condensation product of 2-(diphenylphosphino)benzaldehyde (dpba) and ethyl hydrazinoace-tate (etha) was synthesized and characterized by elemental analyses, IR, and H-1 NMR spectroscopy. The bound ligand is a bidentate (PN chromophore), the remaining two coordination places being occupied by chloride ions in overall square planar geometry. The cytotoxic activity of the complex I and two related Pd(II) and Pt(II) complexes 2 and 3 was tested against a panel of four tumor cell lines. The activity of the complexes was similar to that of cisplatin, the most widely used metal-based antitumor drug. It is important to notice that complexes 2 and 3 were active to cisplatin-resistant U2-OS/Pt cells. Cell cycle alteration investigation, apoptotic assay and gelatin zymography in relation to invasion and metastasis of tumor cells, were performed with all the investigated complexes on Human cervix carcinoma (HeLa) cells. The results suggest that I has a similar effect to cisplatin, inducing apoptosis followed by arrest of cells in S phase of cell cycle, while 2 and 3 induce apoptosis without significant perturbations of cell cycle distribution. (c) 2006 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes
VL  - 100
IS  - 11
SP  - 1811
EP  - 1818
DO  - 10.1016/j.jinorgbio.2006.07.002
UR  - Kon_1715
ER  - 
@article{
author = "Malesevic, Nevenka and Srdić, Tatjana and Radulović, Siniša and Sladić, Dušan and Radulovic, Vesna and Brčeski, Ilija and Anđelković, Katarina K.",
year = "2006",
abstract = "A new palladium(II) complex I of the condensation product of 2-(diphenylphosphino)benzaldehyde (dpba) and ethyl hydrazinoace-tate (etha) was synthesized and characterized by elemental analyses, IR, and H-1 NMR spectroscopy. The bound ligand is a bidentate (PN chromophore), the remaining two coordination places being occupied by chloride ions in overall square planar geometry. The cytotoxic activity of the complex I and two related Pd(II) and Pt(II) complexes 2 and 3 was tested against a panel of four tumor cell lines. The activity of the complexes was similar to that of cisplatin, the most widely used metal-based antitumor drug. It is important to notice that complexes 2 and 3 were active to cisplatin-resistant U2-OS/Pt cells. Cell cycle alteration investigation, apoptotic assay and gelatin zymography in relation to invasion and metastasis of tumor cells, were performed with all the investigated complexes on Human cervix carcinoma (HeLa) cells. The results suggest that I has a similar effect to cisplatin, inducing apoptosis followed by arrest of cells in S phase of cell cycle, while 2 and 3 induce apoptosis without significant perturbations of cell cycle distribution. (c) 2006 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes",
volume = "100",
number = "11",
pages = "1811-1818",
doi = "10.1016/j.jinorgbio.2006.07.002",
url = "Kon_1715"
}
Malesevic, N., Srdić, T., Radulović, S., Sladić, D., Radulovic, V., Brčeski, I.,& Anđelković, K. K.. (2006). Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 100(11), 1811-1818.
https://doi.org/10.1016/j.jinorgbio.2006.07.002
Kon_1715
Malesevic N, Srdić T, Radulović S, Sladić D, Radulovic V, Brčeski I, Anđelković KK. Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes. in Journal of Inorganic Biochemistry. 2006;100(11):1811-1818.
doi:10.1016/j.jinorgbio.2006.07.002
Kon_1715 .
Malesevic, Nevenka, Srdić, Tatjana, Radulović, Siniša, Sladić, Dušan, Radulovic, Vesna, Brčeski, Ilija, Anđelković, Katarina K., "Synthesis and characterization of a novel Pd(II) complex with the condensation product of 2-(diphenylphosphino) benzaldehyde and ethyl hydrazino acetate. Cytotoxic activity of the synthesized complex and related Pd(II) and Pt(II) complexes" in Journal of Inorganic Biochemistry, 100, no. 11 (2006):1811-1818,
https://doi.org/10.1016/j.jinorgbio.2006.07.002 .,
Kon_1715 .
18
20
21