Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200168 (University of Belgrade, Faculty of Chemistry)

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Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200168 (University of Belgrade, Faculty of Chemistry) (en)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 451-03-68/2020-14/200168 (Univerzitet u Beogradu, Hemijski fakultet) (sr_RS)
Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 451-03-68/2020-14/200168 (Универзитет у Београду, Хемијски факултет) (sr)
Authors

Publications

Supplementary material for the article: Vukadinović, J.; Srdić, J.; Tosti, T.; Dragičević, V.; Kravić, N.; Drinić, S. M.; Milojković-Opsenica, D. Alteration in Phytochemicals from Sweet Maize in Response to Domestic Cooking and Frozen Storage. Journal of Food Composition and Analysis 2022, 114, 104637. https://doi.org/10.1016/j.jfca.2022.104637.

Vukadinović, Jelena; Srdić, Jelena; Tosti, Tomislav; Dragičević, Vesna; Kravić, Natalija; Drinić, Snežana Mladenović; Milojković-Opsenica, Dušanka

(Elsevier, 2022)

TY  - DATA
AU  - Vukadinović, Jelena
AU  - Srdić, Jelena
AU  - Tosti, Tomislav
AU  - Dragičević, Vesna
AU  - Kravić, Natalija
AU  - Drinić, Snežana Mladenović
AU  - Milojković-Opsenica, Dušanka
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5518
PB  - Elsevier
T2  - Journal of Food Composition and Analysis
T1  - Supplementary material for the article: Vukadinović, J.; Srdić, J.; Tosti, T.; Dragičević, V.; Kravić, N.; Drinić, S. M.; Milojković-Opsenica, D. Alteration in Phytochemicals from Sweet Maize in Response to Domestic Cooking and Frozen Storage. Journal of Food Composition and Analysis 2022, 114, 104637. https://doi.org/10.1016/j.jfca.2022.104637.
DO  - 10.1016/j.jfca.2022.104637
ER  - 
@misc{
author = "Vukadinović, Jelena and Srdić, Jelena and Tosti, Tomislav and Dragičević, Vesna and Kravić, Natalija and Drinić, Snežana Mladenović and Milojković-Opsenica, Dušanka",
year = "2022",
publisher = "Elsevier",
journal = "Journal of Food Composition and Analysis",
title = "Supplementary material for the article: Vukadinović, J.; Srdić, J.; Tosti, T.; Dragičević, V.; Kravić, N.; Drinić, S. M.; Milojković-Opsenica, D. Alteration in Phytochemicals from Sweet Maize in Response to Domestic Cooking and Frozen Storage. Journal of Food Composition and Analysis 2022, 114, 104637. https://doi.org/10.1016/j.jfca.2022.104637.",
doi = "10.1016/j.jfca.2022.104637"
}
Vukadinović, J., Srdić, J., Tosti, T., Dragičević, V., Kravić, N., Drinić, S. M.,& Milojković-Opsenica, D.. (2022). Supplementary material for the article: Vukadinović, J.; Srdić, J.; Tosti, T.; Dragičević, V.; Kravić, N.; Drinić, S. M.; Milojković-Opsenica, D. Alteration in Phytochemicals from Sweet Maize in Response to Domestic Cooking and Frozen Storage. Journal of Food Composition and Analysis 2022, 114, 104637. https://doi.org/10.1016/j.jfca.2022.104637.. in Journal of Food Composition and Analysis
Elsevier..
https://doi.org/10.1016/j.jfca.2022.104637
Vukadinović J, Srdić J, Tosti T, Dragičević V, Kravić N, Drinić SM, Milojković-Opsenica D. Supplementary material for the article: Vukadinović, J.; Srdić, J.; Tosti, T.; Dragičević, V.; Kravić, N.; Drinić, S. M.; Milojković-Opsenica, D. Alteration in Phytochemicals from Sweet Maize in Response to Domestic Cooking and Frozen Storage. Journal of Food Composition and Analysis 2022, 114, 104637. https://doi.org/10.1016/j.jfca.2022.104637.. in Journal of Food Composition and Analysis. 2022;.
doi:10.1016/j.jfca.2022.104637 .
Vukadinović, Jelena, Srdić, Jelena, Tosti, Tomislav, Dragičević, Vesna, Kravić, Natalija, Drinić, Snežana Mladenović, Milojković-Opsenica, Dušanka, "Supplementary material for the article: Vukadinović, J.; Srdić, J.; Tosti, T.; Dragičević, V.; Kravić, N.; Drinić, S. M.; Milojković-Opsenica, D. Alteration in Phytochemicals from Sweet Maize in Response to Domestic Cooking and Frozen Storage. Journal of Food Composition and Analysis 2022, 114, 104637. https://doi.org/10.1016/j.jfca.2022.104637." in Journal of Food Composition and Analysis (2022),
https://doi.org/10.1016/j.jfca.2022.104637 . .

Supplementary material for the article: Korać Jačić, J.; Milenković, M. R.; Bajuk-Bogdanović, D.; Stanković, D.; Dimitrijević, M.; Spasojević, I. The Impact of Ferric Iron and PH on Photo-Degradation of Tetracycline in Water. Journal of Photochemistry and Photobiology A: Chemistry 2022, 433, 114155. https://doi.org/10.1016/j.jphotochem.2022.114155.

Korać Jačić, Jelena; Milenković, Milica R.; Bajuk-Bogdanović, Danica; Stanković, Dalibor; Dimitrijević, Milena; Spasojević, Ivan

(Elsevier, 2022)

TY  - DATA
AU  - Korać Jačić, Jelena
AU  - Milenković, Milica R.
AU  - Bajuk-Bogdanović, Danica
AU  - Stanković, Dalibor
AU  - Dimitrijević, Milena
AU  - Spasojević, Ivan
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5511
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5512
AB  - There is a significant interest in understanding coordination and photo-chemistry of tetracycline antibiotics, primarily in relation to the development of advanced oxidation processes for degradation of these pollutants in water processing. Herein we analyzed the pH-dependence of interactions of tetracycline with ferric iron and photosensitivity of tetracycline to UV-A and UV-B, using a set of methods – UV–vis, Raman and electron paramagnetic resonance spectroscopy, MS spectrometry, HPLC, and cyclic voltammetry. Tetracycline and Fe3+ mainly bind through amide and OH groups in tricarbonylamide moiety to form a stable complex with 1:1 stoichiometry at pH ≤ 5. The interaction is reversible and tetracycline is released from the complex with pH increase. Tetracycline in the complex is stabilized and less susceptible than free tetracycline to oxidation by hydroxyl radical that is produced by UV-induced photolysis of Fe3+–OH- complexes. Redox properties of tetracycline were altered with increasing pH and it showed increased susceptibility to UV-induced degradation. In close, the system composed of tetracycline and ferric iron shows coordination and photo-redox chemistry that is dependent of pH in relation to the solubility of Fe3+ species and protonation of tetracycline. The development and optimization of advanced oxidation processes should take into account that iron may bind and stabilize pollutants and that the redox landscape of water changes drastically with pH.
PB  - Elsevier
T2  - Journal of Photochemistry & Photobiology, A: Chemistry
T1  - Supplementary material for the article: Korać Jačić, J.; Milenković, M. R.; Bajuk-Bogdanović, D.; Stanković, D.; Dimitrijević, M.; Spasojević, I. The Impact of Ferric Iron and PH on Photo-Degradation of Tetracycline in Water. Journal of Photochemistry and Photobiology A: Chemistry 2022, 433, 114155. https://doi.org/10.1016/j.jphotochem.2022.114155.
VL  - 433
SP  - 114155
ER  - 
@misc{
author = "Korać Jačić, Jelena and Milenković, Milica R. and Bajuk-Bogdanović, Danica and Stanković, Dalibor and Dimitrijević, Milena and Spasojević, Ivan",
year = "2022",
abstract = "There is a significant interest in understanding coordination and photo-chemistry of tetracycline antibiotics, primarily in relation to the development of advanced oxidation processes for degradation of these pollutants in water processing. Herein we analyzed the pH-dependence of interactions of tetracycline with ferric iron and photosensitivity of tetracycline to UV-A and UV-B, using a set of methods – UV–vis, Raman and electron paramagnetic resonance spectroscopy, MS spectrometry, HPLC, and cyclic voltammetry. Tetracycline and Fe3+ mainly bind through amide and OH groups in tricarbonylamide moiety to form a stable complex with 1:1 stoichiometry at pH ≤ 5. The interaction is reversible and tetracycline is released from the complex with pH increase. Tetracycline in the complex is stabilized and less susceptible than free tetracycline to oxidation by hydroxyl radical that is produced by UV-induced photolysis of Fe3+–OH- complexes. Redox properties of tetracycline were altered with increasing pH and it showed increased susceptibility to UV-induced degradation. In close, the system composed of tetracycline and ferric iron shows coordination and photo-redox chemistry that is dependent of pH in relation to the solubility of Fe3+ species and protonation of tetracycline. The development and optimization of advanced oxidation processes should take into account that iron may bind and stabilize pollutants and that the redox landscape of water changes drastically with pH.",
publisher = "Elsevier",
journal = "Journal of Photochemistry & Photobiology, A: Chemistry",
title = "Supplementary material for the article: Korać Jačić, J.; Milenković, M. R.; Bajuk-Bogdanović, D.; Stanković, D.; Dimitrijević, M.; Spasojević, I. The Impact of Ferric Iron and PH on Photo-Degradation of Tetracycline in Water. Journal of Photochemistry and Photobiology A: Chemistry 2022, 433, 114155. https://doi.org/10.1016/j.jphotochem.2022.114155.",
volume = "433",
pages = "114155"
}
Korać Jačić, J., Milenković, M. R., Bajuk-Bogdanović, D., Stanković, D., Dimitrijević, M.,& Spasojević, I.. (2022). Supplementary material for the article: Korać Jačić, J.; Milenković, M. R.; Bajuk-Bogdanović, D.; Stanković, D.; Dimitrijević, M.; Spasojević, I. The Impact of Ferric Iron and PH on Photo-Degradation of Tetracycline in Water. Journal of Photochemistry and Photobiology A: Chemistry 2022, 433, 114155. https://doi.org/10.1016/j.jphotochem.2022.114155.. in Journal of Photochemistry & Photobiology, A: Chemistry
Elsevier., 433, 114155.
Korać Jačić J, Milenković MR, Bajuk-Bogdanović D, Stanković D, Dimitrijević M, Spasojević I. Supplementary material for the article: Korać Jačić, J.; Milenković, M. R.; Bajuk-Bogdanović, D.; Stanković, D.; Dimitrijević, M.; Spasojević, I. The Impact of Ferric Iron and PH on Photo-Degradation of Tetracycline in Water. Journal of Photochemistry and Photobiology A: Chemistry 2022, 433, 114155. https://doi.org/10.1016/j.jphotochem.2022.114155.. in Journal of Photochemistry & Photobiology, A: Chemistry. 2022;433:114155..
Korać Jačić, Jelena, Milenković, Milica R., Bajuk-Bogdanović, Danica, Stanković, Dalibor, Dimitrijević, Milena, Spasojević, Ivan, "Supplementary material for the article: Korać Jačić, J.; Milenković, M. R.; Bajuk-Bogdanović, D.; Stanković, D.; Dimitrijević, M.; Spasojević, I. The Impact of Ferric Iron and PH on Photo-Degradation of Tetracycline in Water. Journal of Photochemistry and Photobiology A: Chemistry 2022, 433, 114155. https://doi.org/10.1016/j.jphotochem.2022.114155." in Journal of Photochemistry & Photobiology, A: Chemistry, 433 (2022):114155.

Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage

Vukadinović, Jelena; Srdić, Jelena; Tosti, Tomislav; Dragičević, Vesna; Kravić, Natalija; Drinić, Snežana Mladenović; Milojković-Opsenica, Dušanka

(Elsevier, 2022)

TY  - JOUR
AU  - Vukadinović, Jelena
AU  - Srdić, Jelena
AU  - Tosti, Tomislav
AU  - Dragičević, Vesna
AU  - Kravić, Natalija
AU  - Drinić, Snežana Mladenović
AU  - Milojković-Opsenica, Dušanka
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5513
AB  - Sweet maize has worldwide importance due to its high nutritional value and health benefits. In order to provide valuable health-related information to consumers, the phytochemicals profile of raw sweet maize kernels and those exposed to different treatments (cooking, frozen storage before cooking, sucrose addition during cooking, and blanching) was examined herein. Thus, carotenoids, tocopherols and free phenolic acids content was determined by liquid chromatography, while the content of water soluble sugars was analyzed by anion exchange chromatography. In response to immediate cooking, as well as, to blanching prior to shorter frozen storage and cooking afterwards, all hybrids exhibited a significant decrease in carotenoids, and a significant increase in concentration of tocopherols, fructose, glucose, protocatechuic, ferulic and p-coumaric acids, in comparison to the fresh samples. However, treatments with blanching prior to longer frozen storage and cooking afterwards, contributed only to increased tocopherols content. Distinct grouping of processed samples in comparison to their corresponding control samples, revealed the existence of unique linkage between changes in phytochemicals content upon treatment in a hybrid-dependent manner. Combined blanching prior to shorter frozen storage with sucrose addition during cooking is highly recommended as a potent tool for phytochemicals enhancement.
PB  - Elsevier
T2  - Journal of Food Composition and AnalysisJournal of Food Composition and Analysis
T1  - Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage
VL  - 114
SP  - 104637
DO  - 10.1016/j.jfca.2022.104637
ER  - 
@article{
author = "Vukadinović, Jelena and Srdić, Jelena and Tosti, Tomislav and Dragičević, Vesna and Kravić, Natalija and Drinić, Snežana Mladenović and Milojković-Opsenica, Dušanka",
year = "2022",
abstract = "Sweet maize has worldwide importance due to its high nutritional value and health benefits. In order to provide valuable health-related information to consumers, the phytochemicals profile of raw sweet maize kernels and those exposed to different treatments (cooking, frozen storage before cooking, sucrose addition during cooking, and blanching) was examined herein. Thus, carotenoids, tocopherols and free phenolic acids content was determined by liquid chromatography, while the content of water soluble sugars was analyzed by anion exchange chromatography. In response to immediate cooking, as well as, to blanching prior to shorter frozen storage and cooking afterwards, all hybrids exhibited a significant decrease in carotenoids, and a significant increase in concentration of tocopherols, fructose, glucose, protocatechuic, ferulic and p-coumaric acids, in comparison to the fresh samples. However, treatments with blanching prior to longer frozen storage and cooking afterwards, contributed only to increased tocopherols content. Distinct grouping of processed samples in comparison to their corresponding control samples, revealed the existence of unique linkage between changes in phytochemicals content upon treatment in a hybrid-dependent manner. Combined blanching prior to shorter frozen storage with sucrose addition during cooking is highly recommended as a potent tool for phytochemicals enhancement.",
publisher = "Elsevier",
journal = "Journal of Food Composition and AnalysisJournal of Food Composition and Analysis",
title = "Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage",
volume = "114",
pages = "104637",
doi = "10.1016/j.jfca.2022.104637"
}
Vukadinović, J., Srdić, J., Tosti, T., Dragičević, V., Kravić, N., Drinić, S. M.,& Milojković-Opsenica, D.. (2022). Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage. in Journal of Food Composition and AnalysisJournal of Food Composition and Analysis
Elsevier., 114, 104637.
https://doi.org/10.1016/j.jfca.2022.104637
Vukadinović J, Srdić J, Tosti T, Dragičević V, Kravić N, Drinić SM, Milojković-Opsenica D. Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage. in Journal of Food Composition and AnalysisJournal of Food Composition and Analysis. 2022;114:104637.
doi:10.1016/j.jfca.2022.104637 .
Vukadinović, Jelena, Srdić, Jelena, Tosti, Tomislav, Dragičević, Vesna, Kravić, Natalija, Drinić, Snežana Mladenović, Milojković-Opsenica, Dušanka, "Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage" in Journal of Food Composition and AnalysisJournal of Food Composition and Analysis, 114 (2022):104637,
https://doi.org/10.1016/j.jfca.2022.104637 . .

Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins

Vitomirov, Teodora; Dimiza, Filitsa; Matić, Ivana Z.; Stanojković, Tatjana; Pirković, Andrea; Živković, Lada; Spremo-Potparević, Biljana; Novaković, Irena; Anđelković, Katarina; Milčić, Miloš; Psomas, George; Ristović, Maja Šumar

(Elsevier, 2022)

TY  - JOUR
AU  - Vitomirov, Teodora
AU  - Dimiza, Filitsa
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana
AU  - Pirković, Andrea
AU  - Živković, Lada
AU  - Spremo-Potparević, Biljana
AU  - Novaković, Irena
AU  - Anđelković, Katarina
AU  - Milčić, Miloš
AU  - Psomas, George
AU  - Ristović, Maja Šumar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5515
AB  - In this article, cytotoxicity, the mechanisms of cytotoxic activity, genotoxicity, and interaction with DNA and proteins, of two Cu(II) complexes with a salicylaldehyde derivative (4-(diethylamino)salicylaldehyde) and α-diimine (2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen)) are reported. Both Cu(II) complexes performed cytotoxic effects against all tested malignant cell lines. Complexes exerted highest cytotoxicity against HeLa and A375 malignant cell lines. The cytotoxic activity of Cu(II) complex with phen as a α-diimine co-ligand was significantly higher in comparison with cytotoxic activity of Cu(II) complex with bipy. Pretreatment with specific inhibitors of caspase-3, caspase-8 or caspase-9, in order to clear up the mode of cell death triggered by two Cu(II) complexes in HeLa cells, indicated the ability of these complexes to induce apoptosis through activation of target caspases. Cu(II)-phen complex exhibited significant antioxidant activity compared with Cu(II)-bipy complex, and showed a better effect on reducing intracellular ROS levels in HeLa cells. Tested complexes did not display genotoxic potential in human peripheral blood leucocytes, but exhibited an antigenotoxic effect in post-treatment, after H2O2 exposure. The study of the in vitro biological properties regarding their affinity towards CT (calf-thymus) DNA and serum albumins showed that the compounds can intercalate to CT DNA, and bind reversibly and tightly to the albumins. Molecular docking studies of the ability of compounds to bind to biomacromolecules are consistent with in vitro studies.
PB  - Elsevier
T2  - Journal of Inorganic BiochemistryJournal of Inorganic Biochemistry
T1  - Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins
VL  - 235
SP  - 111942
DO  - 10.1016/j.jinorgbio.2022.111942
ER  - 
@article{
author = "Vitomirov, Teodora and Dimiza, Filitsa and Matić, Ivana Z. and Stanojković, Tatjana and Pirković, Andrea and Živković, Lada and Spremo-Potparević, Biljana and Novaković, Irena and Anđelković, Katarina and Milčić, Miloš and Psomas, George and Ristović, Maja Šumar",
year = "2022",
abstract = "In this article, cytotoxicity, the mechanisms of cytotoxic activity, genotoxicity, and interaction with DNA and proteins, of two Cu(II) complexes with a salicylaldehyde derivative (4-(diethylamino)salicylaldehyde) and α-diimine (2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen)) are reported. Both Cu(II) complexes performed cytotoxic effects against all tested malignant cell lines. Complexes exerted highest cytotoxicity against HeLa and A375 malignant cell lines. The cytotoxic activity of Cu(II) complex with phen as a α-diimine co-ligand was significantly higher in comparison with cytotoxic activity of Cu(II) complex with bipy. Pretreatment with specific inhibitors of caspase-3, caspase-8 or caspase-9, in order to clear up the mode of cell death triggered by two Cu(II) complexes in HeLa cells, indicated the ability of these complexes to induce apoptosis through activation of target caspases. Cu(II)-phen complex exhibited significant antioxidant activity compared with Cu(II)-bipy complex, and showed a better effect on reducing intracellular ROS levels in HeLa cells. Tested complexes did not display genotoxic potential in human peripheral blood leucocytes, but exhibited an antigenotoxic effect in post-treatment, after H2O2 exposure. The study of the in vitro biological properties regarding their affinity towards CT (calf-thymus) DNA and serum albumins showed that the compounds can intercalate to CT DNA, and bind reversibly and tightly to the albumins. Molecular docking studies of the ability of compounds to bind to biomacromolecules are consistent with in vitro studies.",
publisher = "Elsevier",
journal = "Journal of Inorganic BiochemistryJournal of Inorganic Biochemistry",
title = "Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins",
volume = "235",
pages = "111942",
doi = "10.1016/j.jinorgbio.2022.111942"
}
Vitomirov, T., Dimiza, F., Matić, I. Z., Stanojković, T., Pirković, A., Živković, L., Spremo-Potparević, B., Novaković, I., Anđelković, K., Milčić, M., Psomas, G.,& Ristović, M. Š.. (2022). Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins. in Journal of Inorganic BiochemistryJournal of Inorganic Biochemistry
Elsevier., 235, 111942.
https://doi.org/10.1016/j.jinorgbio.2022.111942
Vitomirov T, Dimiza F, Matić IZ, Stanojković T, Pirković A, Živković L, Spremo-Potparević B, Novaković I, Anđelković K, Milčić M, Psomas G, Ristović MŠ. Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins. in Journal of Inorganic BiochemistryJournal of Inorganic Biochemistry. 2022;235:111942.
doi:10.1016/j.jinorgbio.2022.111942 .
Vitomirov, Teodora, Dimiza, Filitsa, Matić, Ivana Z., Stanojković, Tatjana, Pirković, Andrea, Živković, Lada, Spremo-Potparević, Biljana, Novaković, Irena, Anđelković, Katarina, Milčić, Miloš, Psomas, George, Ristović, Maja Šumar, "Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins" in Journal of Inorganic BiochemistryJournal of Inorganic Biochemistry, 235 (2022):111942,
https://doi.org/10.1016/j.jinorgbio.2022.111942 . .

Supplementary information for the article: Vitomirov, T.; Dimiza, F.; Matić, I. Z.; Stanojković, T.; Pirković, A.; Živković, L.; Spremo-Potparević, B.; Novaković, I.; Anđelković, K.; Milčić, M.; Psomas, G.; Ristović, M. Š. Copper(II) Complexes with 4-(Diethylamino)Salicylaldehyde and α-Diimines: Anticancer, Antioxidant, Antigenotoxic Effects and Interaction with DNA and Albumins. Journal of Inorganic Biochemistry 2022, 235, 111942. https://doi.org/10.1016/j.jinorgbio.2022.111942.

Vitomirov, Teodora; Dimiza, Filitsa; Matić, Ivana Z.; Stanojković, Tatjana; Pirković, Andrea; Živković, Lada; Spremo-Potparević, Biljana; Novaković, Irena; Anđelković, Katarina; Milčić, Miloš; Psomas, George; Ristović, Maja Šumar

(Elsevier, 2022)

TY  - DATA
AU  - Vitomirov, Teodora
AU  - Dimiza, Filitsa
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana
AU  - Pirković, Andrea
AU  - Živković, Lada
AU  - Spremo-Potparević, Biljana
AU  - Novaković, Irena
AU  - Anđelković, Katarina
AU  - Milčić, Miloš
AU  - Psomas, George
AU  - Ristović, Maja Šumar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5519
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Supplementary information for the article: Vitomirov, T.; Dimiza, F.; Matić, I. Z.; Stanojković, T.; Pirković, A.; Živković, L.; Spremo-Potparević, B.; Novaković, I.; Anđelković, K.; Milčić, M.; Psomas, G.; Ristović, M. Š. Copper(II) Complexes with 4-(Diethylamino)Salicylaldehyde and α-Diimines: Anticancer, Antioxidant, Antigenotoxic Effects and Interaction with DNA and Albumins. Journal of Inorganic Biochemistry 2022, 235, 111942. https://doi.org/10.1016/j.jinorgbio.2022.111942.
ER  - 
@misc{
author = "Vitomirov, Teodora and Dimiza, Filitsa and Matić, Ivana Z. and Stanojković, Tatjana and Pirković, Andrea and Živković, Lada and Spremo-Potparević, Biljana and Novaković, Irena and Anđelković, Katarina and Milčić, Miloš and Psomas, George and Ristović, Maja Šumar",
year = "2022",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Supplementary information for the article: Vitomirov, T.; Dimiza, F.; Matić, I. Z.; Stanojković, T.; Pirković, A.; Živković, L.; Spremo-Potparević, B.; Novaković, I.; Anđelković, K.; Milčić, M.; Psomas, G.; Ristović, M. Š. Copper(II) Complexes with 4-(Diethylamino)Salicylaldehyde and α-Diimines: Anticancer, Antioxidant, Antigenotoxic Effects and Interaction with DNA and Albumins. Journal of Inorganic Biochemistry 2022, 235, 111942. https://doi.org/10.1016/j.jinorgbio.2022.111942."
}
Vitomirov, T., Dimiza, F., Matić, I. Z., Stanojković, T., Pirković, A., Živković, L., Spremo-Potparević, B., Novaković, I., Anđelković, K., Milčić, M., Psomas, G.,& Ristović, M. Š.. (2022). Supplementary information for the article: Vitomirov, T.; Dimiza, F.; Matić, I. Z.; Stanojković, T.; Pirković, A.; Živković, L.; Spremo-Potparević, B.; Novaković, I.; Anđelković, K.; Milčić, M.; Psomas, G.; Ristović, M. Š. Copper(II) Complexes with 4-(Diethylamino)Salicylaldehyde and α-Diimines: Anticancer, Antioxidant, Antigenotoxic Effects and Interaction with DNA and Albumins. Journal of Inorganic Biochemistry 2022, 235, 111942. https://doi.org/10.1016/j.jinorgbio.2022.111942.. in Journal of Inorganic Biochemistry
Elsevier..
Vitomirov T, Dimiza F, Matić IZ, Stanojković T, Pirković A, Živković L, Spremo-Potparević B, Novaković I, Anđelković K, Milčić M, Psomas G, Ristović MŠ. Supplementary information for the article: Vitomirov, T.; Dimiza, F.; Matić, I. Z.; Stanojković, T.; Pirković, A.; Živković, L.; Spremo-Potparević, B.; Novaković, I.; Anđelković, K.; Milčić, M.; Psomas, G.; Ristović, M. Š. Copper(II) Complexes with 4-(Diethylamino)Salicylaldehyde and α-Diimines: Anticancer, Antioxidant, Antigenotoxic Effects and Interaction with DNA and Albumins. Journal of Inorganic Biochemistry 2022, 235, 111942. https://doi.org/10.1016/j.jinorgbio.2022.111942.. in Journal of Inorganic Biochemistry. 2022;..
Vitomirov, Teodora, Dimiza, Filitsa, Matić, Ivana Z., Stanojković, Tatjana, Pirković, Andrea, Živković, Lada, Spremo-Potparević, Biljana, Novaković, Irena, Anđelković, Katarina, Milčić, Miloš, Psomas, George, Ristović, Maja Šumar, "Supplementary information for the article: Vitomirov, T.; Dimiza, F.; Matić, I. Z.; Stanojković, T.; Pirković, A.; Živković, L.; Spremo-Potparević, B.; Novaković, I.; Anđelković, K.; Milčić, M.; Psomas, G.; Ristović, M. Š. Copper(II) Complexes with 4-(Diethylamino)Salicylaldehyde and α-Diimines: Anticancer, Antioxidant, Antigenotoxic Effects and Interaction with DNA and Albumins. Journal of Inorganic Biochemistry 2022, 235, 111942. https://doi.org/10.1016/j.jinorgbio.2022.111942." in Journal of Inorganic Biochemistry (2022).

Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types

Mikavica, Ivana; Ranđelović, Dragana; Đorđević, Vladan; Rakić, Tamara; Gajić, Gordana; Mutić, Jelena

(2022)

TY  - JOUR
AU  - Mikavica, Ivana
AU  - Ranđelović, Dragana
AU  - Đorđević, Vladan
AU  - Rakić, Tamara
AU  - Gajić, Gordana
AU  - Mutić, Jelena
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5516
AB  - The mobility of chemical elements in the soil-orchid system has been poorly studied. The aim of this study is to evaluate the uptake and mobility of several trace (Li, Ba, Sr, Ag, Hg, and B) and macronutrients (Ca, Mg, and K) in the orchid Anacamptis morio (L.) R.M.Bateman, Pridgeon & M.W.Chase from soils in western Serbia. The sampling sites are characterized by three different bedrock types—cherts, limestones, and serpentines, which are the source of the significant chemical differences in the elemental status of the soil and plant tissues. The four-step Community Bureau of Reference sequential extraction procedure was used to determine the distribution of fractions and predict their potential phytoavailability. The orchid and soil samples were analyzed for total elemental content analysis using ICP-OES. The greatest potential for plant availability was determined for Ba and Sr, representing about 80% of the total soil content. More than 40% of Li in the soils was found to be potentially phytoavailable. Significant correlations were found between the total content of Li, B, and Sr in soils. Between 38 and 60% of Li content and more than 80% of Ba and Sr content were determined to be potentially phytoavailable by sequential analysis. The highest bioconcentration factor (> 1) was determined in the case of B and Sr for all orchid organs, while translocation factor for Li was highest in tubers and leaves. The studied elements were mainly stored in tubers and roots, indicating the exclusion strategy of A. morio as a metal tolerance mechanism. The data obtained showed significant differences in metal content in soils and plants originating from sites with different parent materials, suggesting that bedrock type and associated soil properties are important factors that determine chemical element mobility and uptake. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
T2  - Environmental Science and Pollution Research
T2  - Environmental Science and Pollution Research
T1  - Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types
DO  - 10.1007/s11356-022-22110-z
ER  - 
@article{
author = "Mikavica, Ivana and Ranđelović, Dragana and Đorđević, Vladan and Rakić, Tamara and Gajić, Gordana and Mutić, Jelena",
year = "2022",
abstract = "The mobility of chemical elements in the soil-orchid system has been poorly studied. The aim of this study is to evaluate the uptake and mobility of several trace (Li, Ba, Sr, Ag, Hg, and B) and macronutrients (Ca, Mg, and K) in the orchid Anacamptis morio (L.) R.M.Bateman, Pridgeon & M.W.Chase from soils in western Serbia. The sampling sites are characterized by three different bedrock types—cherts, limestones, and serpentines, which are the source of the significant chemical differences in the elemental status of the soil and plant tissues. The four-step Community Bureau of Reference sequential extraction procedure was used to determine the distribution of fractions and predict their potential phytoavailability. The orchid and soil samples were analyzed for total elemental content analysis using ICP-OES. The greatest potential for plant availability was determined for Ba and Sr, representing about 80% of the total soil content. More than 40% of Li in the soils was found to be potentially phytoavailable. Significant correlations were found between the total content of Li, B, and Sr in soils. Between 38 and 60% of Li content and more than 80% of Ba and Sr content were determined to be potentially phytoavailable by sequential analysis. The highest bioconcentration factor (> 1) was determined in the case of B and Sr for all orchid organs, while translocation factor for Li was highest in tubers and leaves. The studied elements were mainly stored in tubers and roots, indicating the exclusion strategy of A. morio as a metal tolerance mechanism. The data obtained showed significant differences in metal content in soils and plants originating from sites with different parent materials, suggesting that bedrock type and associated soil properties are important factors that determine chemical element mobility and uptake. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",
journal = "Environmental Science and Pollution Research, Environmental Science and Pollution Research",
title = "Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types",
doi = "10.1007/s11356-022-22110-z"
}
Mikavica, I., Ranđelović, D., Đorđević, V., Rakić, T., Gajić, G.,& Mutić, J.. (2022). Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types. in Environmental Science and Pollution Research.
https://doi.org/10.1007/s11356-022-22110-z
Mikavica I, Ranđelović D, Đorđević V, Rakić T, Gajić G, Mutić J. Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types. in Environmental Science and Pollution Research. 2022;.
doi:10.1007/s11356-022-22110-z .
Mikavica, Ivana, Ranđelović, Dragana, Đorđević, Vladan, Rakić, Tamara, Gajić, Gordana, Mutić, Jelena, "Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types" in Environmental Science and Pollution Research (2022),
https://doi.org/10.1007/s11356-022-22110-z . .

Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production

Stojanović, Sanja; Ristović, Marina; Stepanović, Jelena; Margetić, Aleksandra; Duduk, Bojan; Vujčić, Zoran; Dojnov, Biljana

(Elsevier, 2022)

TY  - JOUR
AU  - Stojanović, Sanja
AU  - Ristović, Marina
AU  - Stepanović, Jelena
AU  - Margetić, Aleksandra
AU  - Duduk, Bojan
AU  - Vujčić, Zoran
AU  - Dojnov, Biljana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5517
AB  - Production of fructooligosaccharides (FOS) is a trending topic due to their prebiotic effect becoming increasingly important for the modern human diet. The most suitable process for FOS production is the one using fungal inulinases. Introduction of new fungal inulinase producers and their implementation in production of inulinase enzymes is therefore gaining interest. This study provides a new approach to FOS synthesis by fungal enzyme complex without prior separation of any specific enzyme. Inulinase enzyme complexes could be used for the synthesis of FOS in two possible ways – hydrolysis of inulin (FOSh) and transfructosylation process of sucrose (FOSs), as demonstrated here. Depending on the fungal growth inducing substrate, a variety of inulinase enzyme complexes was obtained – one of which was most successful in production of FOSh and another one of FOSs. Substrates derived from crops: triticale, wheat bran, Jerusalem artichoke and Aspergillus welwitschiae isolate, previously proven as safe for use in food, were utilized for production of inulinase enzyme cocktails. The highest FOSs production was obtained by enzyme complex rich in β-fructofuranosidase, while the highest FOSh production was obtained by enzyme complex rich in endoinulinase. Both FOSh and FOSs showed antioxidant potential according to ABTS and ORAC, which classifies them as a suitable additive in functional food. Simultaneous zymographic detection of inulinase enzymes, which could contribute to expansion of the knowledge on fungal enzymes, was developed and applied here. It demonstrated the presence of different inulinase isoforms depending on fungal growth substrate. These findings, which rely on the innate ability of fungi to co-produce all inulinases from a cocktail, could be useful as a new, easy approach to FOS production by fungal enzymes without their separation and purification, contributing to cheaper and faster production processes. © 2022 Elsevier Ltd
PB  - Elsevier
T2  - Food Research International
T2  - Food Research International
T1  - Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production
VL  - 160
DO  - 10.1016/j.foodres.2022.111755
ER  - 
@article{
author = "Stojanović, Sanja and Ristović, Marina and Stepanović, Jelena and Margetić, Aleksandra and Duduk, Bojan and Vujčić, Zoran and Dojnov, Biljana",
year = "2022",
abstract = "Production of fructooligosaccharides (FOS) is a trending topic due to their prebiotic effect becoming increasingly important for the modern human diet. The most suitable process for FOS production is the one using fungal inulinases. Introduction of new fungal inulinase producers and their implementation in production of inulinase enzymes is therefore gaining interest. This study provides a new approach to FOS synthesis by fungal enzyme complex without prior separation of any specific enzyme. Inulinase enzyme complexes could be used for the synthesis of FOS in two possible ways – hydrolysis of inulin (FOSh) and transfructosylation process of sucrose (FOSs), as demonstrated here. Depending on the fungal growth inducing substrate, a variety of inulinase enzyme complexes was obtained – one of which was most successful in production of FOSh and another one of FOSs. Substrates derived from crops: triticale, wheat bran, Jerusalem artichoke and Aspergillus welwitschiae isolate, previously proven as safe for use in food, were utilized for production of inulinase enzyme cocktails. The highest FOSs production was obtained by enzyme complex rich in β-fructofuranosidase, while the highest FOSh production was obtained by enzyme complex rich in endoinulinase. Both FOSh and FOSs showed antioxidant potential according to ABTS and ORAC, which classifies them as a suitable additive in functional food. Simultaneous zymographic detection of inulinase enzymes, which could contribute to expansion of the knowledge on fungal enzymes, was developed and applied here. It demonstrated the presence of different inulinase isoforms depending on fungal growth substrate. These findings, which rely on the innate ability of fungi to co-produce all inulinases from a cocktail, could be useful as a new, easy approach to FOS production by fungal enzymes without their separation and purification, contributing to cheaper and faster production processes. © 2022 Elsevier Ltd",
publisher = "Elsevier",
journal = "Food Research International, Food Research International",
title = "Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production",
volume = "160",
doi = "10.1016/j.foodres.2022.111755"
}
Stojanović, S., Ristović, M., Stepanović, J., Margetić, A., Duduk, B., Vujčić, Z.,& Dojnov, B.. (2022). Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production. in Food Research International
Elsevier., 160.
https://doi.org/10.1016/j.foodres.2022.111755
Stojanović S, Ristović M, Stepanović J, Margetić A, Duduk B, Vujčić Z, Dojnov B. Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production. in Food Research International. 2022;160.
doi:10.1016/j.foodres.2022.111755 .
Stojanović, Sanja, Ristović, Marina, Stepanović, Jelena, Margetić, Aleksandra, Duduk, Bojan, Vujčić, Zoran, Dojnov, Biljana, "Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production" in Food Research International, 160 (2022),
https://doi.org/10.1016/j.foodres.2022.111755 . .

The impact of ferric iron and pH on photo-degradation of tetracycline in water

Korać Jačić, Jelena; Milenković, Milica R.; Bajuk-Bogdanović, Danica; Stanković, Dalibor; Dimitrijević, Milena; Spasojević, Ivan

(Elsevier, 2022)

TY  - JOUR
AU  - Korać Jačić, Jelena
AU  - Milenković, Milica R.
AU  - Bajuk-Bogdanović, Danica
AU  - Stanković, Dalibor
AU  - Dimitrijević, Milena
AU  - Spasojević, Ivan
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5511
AB  - There is a significant interest in understanding coordination and photo-chemistry of tetracycline antibiotics, primarily in relation to the development of advanced oxidation processes for degradation of these pollutants in water processing. Herein we analyzed the pH-dependence of interactions of tetracycline with ferric iron and photosensitivity of tetracycline to UV-A and UV-B, using a set of methods – UV–vis, Raman and electron paramagnetic resonance spectroscopy, MS spectrometry, HPLC, and cyclic voltammetry. Tetracycline and Fe3+ mainly bind through amide and OH groups in tricarbonylamide moiety to form a stable complex with 1:1 stoichiometry at pH ≤ 5. The interaction is reversible and tetracycline is released from the complex with pH increase. Tetracycline in the complex is stabilized and less susceptible than free tetracycline to oxidation by hydroxyl radical that is produced by UV-induced photolysis of Fe3+–OH- complexes. Redox properties of tetracycline were altered with increasing pH and it showed increased susceptibility to UV-induced degradation. In close, the system composed of tetracycline and ferric iron shows coordination and photo-redox chemistry that is dependent of pH in relation to the solubility of Fe3+ species and protonation of tetracycline. The development and optimization of advanced oxidation processes should take into account that iron may bind and stabilize pollutants and that the redox landscape of water changes drastically with pH.
PB  - Elsevier
T2  - Journal of Photochemistry and Photobiology A: ChemistryJournal of Photochemistry and Photobiology A: Chemistry
T1  - The impact of ferric iron and pH on photo-degradation of tetracycline in water
VL  - 433
SP  - 114155
DO  - 10.1016/j.jphotochem.2022.114155
ER  - 
@article{
author = "Korać Jačić, Jelena and Milenković, Milica R. and Bajuk-Bogdanović, Danica and Stanković, Dalibor and Dimitrijević, Milena and Spasojević, Ivan",
year = "2022",
abstract = "There is a significant interest in understanding coordination and photo-chemistry of tetracycline antibiotics, primarily in relation to the development of advanced oxidation processes for degradation of these pollutants in water processing. Herein we analyzed the pH-dependence of interactions of tetracycline with ferric iron and photosensitivity of tetracycline to UV-A and UV-B, using a set of methods – UV–vis, Raman and electron paramagnetic resonance spectroscopy, MS spectrometry, HPLC, and cyclic voltammetry. Tetracycline and Fe3+ mainly bind through amide and OH groups in tricarbonylamide moiety to form a stable complex with 1:1 stoichiometry at pH ≤ 5. The interaction is reversible and tetracycline is released from the complex with pH increase. Tetracycline in the complex is stabilized and less susceptible than free tetracycline to oxidation by hydroxyl radical that is produced by UV-induced photolysis of Fe3+–OH- complexes. Redox properties of tetracycline were altered with increasing pH and it showed increased susceptibility to UV-induced degradation. In close, the system composed of tetracycline and ferric iron shows coordination and photo-redox chemistry that is dependent of pH in relation to the solubility of Fe3+ species and protonation of tetracycline. The development and optimization of advanced oxidation processes should take into account that iron may bind and stabilize pollutants and that the redox landscape of water changes drastically with pH.",
publisher = "Elsevier",
journal = "Journal of Photochemistry and Photobiology A: ChemistryJournal of Photochemistry and Photobiology A: Chemistry",
title = "The impact of ferric iron and pH on photo-degradation of tetracycline in water",
volume = "433",
pages = "114155",
doi = "10.1016/j.jphotochem.2022.114155"
}
Korać Jačić, J., Milenković, M. R., Bajuk-Bogdanović, D., Stanković, D., Dimitrijević, M.,& Spasojević, I.. (2022). The impact of ferric iron and pH on photo-degradation of tetracycline in water. in Journal of Photochemistry and Photobiology A: ChemistryJournal of Photochemistry and Photobiology A: Chemistry
Elsevier., 433, 114155.
https://doi.org/10.1016/j.jphotochem.2022.114155
Korać Jačić J, Milenković MR, Bajuk-Bogdanović D, Stanković D, Dimitrijević M, Spasojević I. The impact of ferric iron and pH on photo-degradation of tetracycline in water. in Journal of Photochemistry and Photobiology A: ChemistryJournal of Photochemistry and Photobiology A: Chemistry. 2022;433:114155.
doi:10.1016/j.jphotochem.2022.114155 .
Korać Jačić, Jelena, Milenković, Milica R., Bajuk-Bogdanović, Danica, Stanković, Dalibor, Dimitrijević, Milena, Spasojević, Ivan, "The impact of ferric iron and pH on photo-degradation of tetracycline in water" in Journal of Photochemistry and Photobiology A: ChemistryJournal of Photochemistry and Photobiology A: Chemistry, 433 (2022):114155,
https://doi.org/10.1016/j.jphotochem.2022.114155 . .

Investigations on the role of cation–pi interactions in active centres of superoxide dismutase

Stojanović, Srđan Đ.; Zlatović, Mario V.

(0352-5139, 2022)

TY  - JOUR
AU  - Stojanović, Srđan Đ.
AU  - Zlatović, Mario V.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5507
AB  - In this study, we have analysed the influence of cation–π interactions on stability and properties of superoxide dismutase (SOD) active centres. The number of interactions formed by arginine is higher than by lysine in the cat­ionic group, while those formed by histidine are comparatively higher in the π group. The energy contribution resulting from most frequent cation–π interact­ions was in the lower range of strong hydrogen bonds. The cation–π interact­ions involving transition metal ions as cation have energy more negative than –418.4 kJ mol-1. The stabilization centres for these proteins showed that all the residues involved in cation–π interactions were important in locating one or more of such centres. The majority of the residues involved in cation–p inter­actions were evolutionarily conserved and might have a significant contribution towards the stability of SOD proteins. The results presented in this work can be very useful for understanding the contribution of cation–π interactions to the stability of SOD active centres.
PB  - 0352-5139
T2  - The Journal of the Serbian Chemical Society
T1  - Investigations on the role of cation–pi interactions in active centres of superoxide dismutase
VL  - 87
IS  - 4
SP  - 465
EP  - 477
DO  - 10.2298/JSC220109013S
ER  - 
@article{
author = "Stojanović, Srđan Đ. and Zlatović, Mario V.",
year = "2022",
abstract = "In this study, we have analysed the influence of cation–π interactions on stability and properties of superoxide dismutase (SOD) active centres. The number of interactions formed by arginine is higher than by lysine in the cat­ionic group, while those formed by histidine are comparatively higher in the π group. The energy contribution resulting from most frequent cation–π interact­ions was in the lower range of strong hydrogen bonds. The cation–π interact­ions involving transition metal ions as cation have energy more negative than –418.4 kJ mol-1. The stabilization centres for these proteins showed that all the residues involved in cation–π interactions were important in locating one or more of such centres. The majority of the residues involved in cation–p inter­actions were evolutionarily conserved and might have a significant contribution towards the stability of SOD proteins. The results presented in this work can be very useful for understanding the contribution of cation–π interactions to the stability of SOD active centres.",
publisher = "0352-5139",
journal = "The Journal of the Serbian Chemical Society",
title = "Investigations on the role of cation–pi interactions in active centres of superoxide dismutase",
volume = "87",
number = "4",
pages = "465-477",
doi = "10.2298/JSC220109013S"
}
Stojanović, S. Đ.,& Zlatović, M. V.. (2022). Investigations on the role of cation–pi interactions in active centres of superoxide dismutase. in The Journal of the Serbian Chemical Society
0352-5139., 87(4), 465-477.
https://doi.org/10.2298/JSC220109013S
Stojanović SĐ, Zlatović MV. Investigations on the role of cation–pi interactions in active centres of superoxide dismutase. in The Journal of the Serbian Chemical Society. 2022;87(4):465-477.
doi:10.2298/JSC220109013S .
Stojanović, Srđan Đ., Zlatović, Mario V., "Investigations on the role of cation–pi interactions in active centres of superoxide dismutase" in The Journal of the Serbian Chemical Society, 87, no. 4 (2022):465-477,
https://doi.org/10.2298/JSC220109013S . .
1

Polyphenolic and Chemical Profiles of Honey From the Tara Mountain in Serbia

Nedić, Nebojša; Nešović, Milica; Radišić, Predrag; Gašić, Uroš; Baošić, Rada; Joksimović, Kristina; Pezo, Lato; Tešić, Živoslav; Vovk, Irena

(Frontiers Media S.A., 2022)

TY  - JOUR
AU  - Nedić, Nebojša
AU  - Nešović, Milica
AU  - Radišić, Predrag
AU  - Gašić, Uroš
AU  - Baošić, Rada
AU  - Joksimović, Kristina
AU  - Pezo, Lato
AU  - Tešić, Živoslav
AU  - Vovk, Irena
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5505
AB  - This study presents a detailed characterization of 27 honey samples from the Tara Mountain region in Serbia using different comprehensive techniques and methods. The types of the honey samples were defined as monofloral (4 samples), honeydew (5 samples) and polyfloral (18 samples) honey based on determined polyphenol content, antioxidant activity, electrical conductivity and melissopalynological analyses. Physicochemical parameters such as pH (4.13–4.94), diastase activity (24.20–41.70 DN), acidity (14.60–29.70 meq/kg), content of 5-(hydroxymethyl)furfural (in range below 5, up to 16.90 mg/kg), sucrose (0.20–3.90 g/100 g), and moisture content (15.01–19.23%) confirmed the required quality of the honey samples. Sensory analysis revealed honey characteristics favorable to consumers. Analyses of 19 phenolic compounds using ultra-high-performance liquid chromatography with a diode-array detection and triple quadrupole mass spectrometry (UHPLC-DAD-MS/MS) revealed six phenolic acids and 13 other compounds from the group of flavonoids and their glycosides. In all the samples the highest content was determined for p-coumaric acid, followed by caffeic acid and pinocembrin. Besides total phenolic content and radical scavenging activity, antimicrobial activity was also examined. Most honey samples showed bactericidal activity against Staphylococcus aureus and bacteriostatic activity against Escherichia coli, while none of the honey samples inhibited the growth of Candida albicans. Chemometric analyses were applied for an in-depth study of the results to further evaluate the characteristics of the honey samples studied. Principal component analysis (PCA) was used for assessing the differences in physicochemical parameters, polyphenols content and antioxidant capacity between honey samples. The unrooted cluster tree was used to group the samples based on the melissopalynological analyses.
PB  - Frontiers Media S.A.
T2  - Frontiers in Nutrition
T2  - Frontiers in Nutrition
T1  - Polyphenolic and Chemical Profiles of Honey From the Tara Mountain in Serbia
VL  - 9
DO  - 10.3389/fnut.2022.941463
ER  - 
@article{
author = "Nedić, Nebojša and Nešović, Milica and Radišić, Predrag and Gašić, Uroš and Baošić, Rada and Joksimović, Kristina and Pezo, Lato and Tešić, Živoslav and Vovk, Irena",
year = "2022",
abstract = "This study presents a detailed characterization of 27 honey samples from the Tara Mountain region in Serbia using different comprehensive techniques and methods. The types of the honey samples were defined as monofloral (4 samples), honeydew (5 samples) and polyfloral (18 samples) honey based on determined polyphenol content, antioxidant activity, electrical conductivity and melissopalynological analyses. Physicochemical parameters such as pH (4.13–4.94), diastase activity (24.20–41.70 DN), acidity (14.60–29.70 meq/kg), content of 5-(hydroxymethyl)furfural (in range below 5, up to 16.90 mg/kg), sucrose (0.20–3.90 g/100 g), and moisture content (15.01–19.23%) confirmed the required quality of the honey samples. Sensory analysis revealed honey characteristics favorable to consumers. Analyses of 19 phenolic compounds using ultra-high-performance liquid chromatography with a diode-array detection and triple quadrupole mass spectrometry (UHPLC-DAD-MS/MS) revealed six phenolic acids and 13 other compounds from the group of flavonoids and their glycosides. In all the samples the highest content was determined for p-coumaric acid, followed by caffeic acid and pinocembrin. Besides total phenolic content and radical scavenging activity, antimicrobial activity was also examined. Most honey samples showed bactericidal activity against Staphylococcus aureus and bacteriostatic activity against Escherichia coli, while none of the honey samples inhibited the growth of Candida albicans. Chemometric analyses were applied for an in-depth study of the results to further evaluate the characteristics of the honey samples studied. Principal component analysis (PCA) was used for assessing the differences in physicochemical parameters, polyphenols content and antioxidant capacity between honey samples. The unrooted cluster tree was used to group the samples based on the melissopalynological analyses.",
publisher = "Frontiers Media S.A.",
journal = "Frontiers in Nutrition, Frontiers in Nutrition",
title = "Polyphenolic and Chemical Profiles of Honey From the Tara Mountain in Serbia",
volume = "9",
doi = "10.3389/fnut.2022.941463"
}
Nedić, N., Nešović, M., Radišić, P., Gašić, U., Baošić, R., Joksimović, K., Pezo, L., Tešić, Ž.,& Vovk, I.. (2022). Polyphenolic and Chemical Profiles of Honey From the Tara Mountain in Serbia. in Frontiers in Nutrition
Frontiers Media S.A.., 9.
https://doi.org/10.3389/fnut.2022.941463
Nedić N, Nešović M, Radišić P, Gašić U, Baošić R, Joksimović K, Pezo L, Tešić Ž, Vovk I. Polyphenolic and Chemical Profiles of Honey From the Tara Mountain in Serbia. in Frontiers in Nutrition. 2022;9.
doi:10.3389/fnut.2022.941463 .
Nedić, Nebojša, Nešović, Milica, Radišić, Predrag, Gašić, Uroš, Baošić, Rada, Joksimović, Kristina, Pezo, Lato, Tešić, Živoslav, Vovk, Irena, "Polyphenolic and Chemical Profiles of Honey From the Tara Mountain in Serbia" in Frontiers in Nutrition, 9 (2022),
https://doi.org/10.3389/fnut.2022.941463 . .

Mineral and nutritional assessments of soybean, buckwheat, spelt, and maize grains grown conventionally and organically

Golijan, Jelena M.; Lekić, Sljavoljub S.; Dojčinović, Biljana P.; Dramićanin, Aleksandra M.; Milinčić, Danijel D.; Pešić, Mirjana B.; Barać, Miroljub B.; Kostić, Aleksandar Ž.

(2022)

TY  - JOUR
AU  - Golijan, Jelena M.
AU  - Lekić, Sljavoljub S.
AU  - Dojčinović, Biljana P.
AU  - Dramićanin, Aleksandra M.
AU  - Milinčić, Danijel D.
AU  - Pešić, Mirjana B.
AU  - Barać, Miroljub B.
AU  - Kostić, Aleksandar Ž.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5504
AB  - The present work determined complete mineral profile of four different types of grains 
(spelt, soybean, maize, and buckwheat) grown under two growing systems – conventional 
and organic. The contents of 20 macro-, micro- and trace elements were analysed in the 
examined grains by inductively coupled plasma-optical emission spectrometry (ICP-OES). 
In most samples, nine elements were present in concentrations higher than 10 mg/kg. The 
remaining elements were present at lower concentrations or in traces or not detected in 
certain samples. Aluminium and arsenic, as two toxic elements, were detected only in 
organic buckwheat grains. Based on the obtained results for the mineral contents, a nutritive 
assessment of the quality of grains of spelt, soybean, maize, and buckwheat were made.
Results of nutritional assessment showed that spelt, soybean, and buckwheat grains could 
potentially be good sources of several minerals for human diet. On the other hand, the 
presence of some toxic elements, such as cadmium and strontium, should be monitored. 
Results of principal component analysis (PCA) and hierarchical cluster analysis (HCA) 
shown that the mineral composition, to a much greater extent, depended on the botanical 
origin of grains as compared to the production system.
T2  - International Food Research Journal
T1  - Mineral and nutritional assessments of soybean, buckwheat, spelt, and maize grains grown conventionally and organically
VL  - 29
IS  - 3
SP  - 646
EP  - 658
DO  - 10.47836/ifrj.29.3.16
ER  - 
@article{
author = "Golijan, Jelena M. and Lekić, Sljavoljub S. and Dojčinović, Biljana P. and Dramićanin, Aleksandra M. and Milinčić, Danijel D. and Pešić, Mirjana B. and Barać, Miroljub B. and Kostić, Aleksandar Ž.",
year = "2022",
abstract = "The present work determined complete mineral profile of four different types of grains 
(spelt, soybean, maize, and buckwheat) grown under two growing systems – conventional 
and organic. The contents of 20 macro-, micro- and trace elements were analysed in the 
examined grains by inductively coupled plasma-optical emission spectrometry (ICP-OES). 
In most samples, nine elements were present in concentrations higher than 10 mg/kg. The 
remaining elements were present at lower concentrations or in traces or not detected in 
certain samples. Aluminium and arsenic, as two toxic elements, were detected only in 
organic buckwheat grains. Based on the obtained results for the mineral contents, a nutritive 
assessment of the quality of grains of spelt, soybean, maize, and buckwheat were made.
Results of nutritional assessment showed that spelt, soybean, and buckwheat grains could 
potentially be good sources of several minerals for human diet. On the other hand, the 
presence of some toxic elements, such as cadmium and strontium, should be monitored. 
Results of principal component analysis (PCA) and hierarchical cluster analysis (HCA) 
shown that the mineral composition, to a much greater extent, depended on the botanical 
origin of grains as compared to the production system.",
journal = "International Food Research Journal",
title = "Mineral and nutritional assessments of soybean, buckwheat, spelt, and maize grains grown conventionally and organically",
volume = "29",
number = "3",
pages = "646-658",
doi = "10.47836/ifrj.29.3.16"
}
Golijan, J. M., Lekić, S. S., Dojčinović, B. P., Dramićanin, A. M., Milinčić, D. D., Pešić, M. B., Barać, M. B.,& Kostić, A. Ž.. (2022). Mineral and nutritional assessments of soybean, buckwheat, spelt, and maize grains grown conventionally and organically. in International Food Research Journal, 29(3), 646-658.
https://doi.org/10.47836/ifrj.29.3.16
Golijan JM, Lekić SS, Dojčinović BP, Dramićanin AM, Milinčić DD, Pešić MB, Barać MB, Kostić AŽ. Mineral and nutritional assessments of soybean, buckwheat, spelt, and maize grains grown conventionally and organically. in International Food Research Journal. 2022;29(3):646-658.
doi:10.47836/ifrj.29.3.16 .
Golijan, Jelena M., Lekić, Sljavoljub S., Dojčinović, Biljana P., Dramićanin, Aleksandra M., Milinčić, Danijel D., Pešić, Mirjana B., Barać, Miroljub B., Kostić, Aleksandar Ž., "Mineral and nutritional assessments of soybean, buckwheat, spelt, and maize grains grown conventionally and organically" in International Food Research Journal, 29, no. 3 (2022):646-658,
https://doi.org/10.47836/ifrj.29.3.16 . .

Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats

Perić, Ivana; Lješević, Marija; Beškoski, Vladimir P.; Nikolić, Milan; Filipović, Dragana

(2022)

TY  - JOUR
AU  - Perić, Ivana
AU  - Lješević, Marija
AU  - Beškoski, Vladimir P.
AU  - Nikolić, Milan
AU  - Filipović, Dragana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5499
AB  - Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.
T2  - Psychopharmacology
T1  - Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats
VL  - n/a
DO  - 10.1007/s00213-022-06180-y
ER  - 
@article{
author = "Perić, Ivana and Lješević, Marija and Beškoski, Vladimir P. and Nikolić, Milan and Filipović, Dragana",
year = "2022",
abstract = "Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.",
journal = "Psychopharmacology",
title = "Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats",
volume = "n/a",
doi = "10.1007/s00213-022-06180-y"
}
Perić, I., Lješević, M., Beškoski, V. P., Nikolić, M.,& Filipović, D.. (2022). Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. in Psychopharmacology, n/a.
https://doi.org/10.1007/s00213-022-06180-y
Perić I, Lješević M, Beškoski VP, Nikolić M, Filipović D. Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. in Psychopharmacology. 2022;n/a.
doi:10.1007/s00213-022-06180-y .
Perić, Ivana, Lješević, Marija, Beškoski, Vladimir P., Nikolić, Milan, Filipović, Dragana, "Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats" in Psychopharmacology, n/a (2022),
https://doi.org/10.1007/s00213-022-06180-y . .
1
1

Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time

Koprivica, Marija; Milojković-Opsenica, Dušanka; Fotirić Akšić, Milica; Dramićanin, Aleksandra M.; Lazarević, Kristina

(2022)

TY  - JOUR
AU  - Koprivica, Marija
AU  - Milojković-Opsenica, Dušanka
AU  - Fotirić Akšić, Milica
AU  - Dramićanin, Aleksandra M.
AU  - Lazarević, Kristina
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5498
AB  - The peach stones and kernels are easily available biowaste which could be useful for the extraction of nutritionally important compounds such as fatty acids. Except in industry, characterization of stones and kernels could be useful in pomology to describe different cultivars, and for selecting new parents in a breeding program. A total of 25 samples of stones and kernels from various peach cultivars that differed in origin and ripening time, but growing in the same climatic conditions, were characterized by fatty acids composition and physical properties. This work confirmed that unsaturated fatty acids (oleic and linoleic fatty acids) were the most represented in peach kernel oil and their content depended of peach genotype. Additionally, the fatty acids in combination with length, weight, and moisture of peach kernels could be used as a parameter of authenticity assessment. This research may contribute for the peach cultivar discrimination and recommendation of cultivars/genotypes with high kernel quality which could be used for the extractions of oil rich in unsaturated fatty acids and further use in food, pharmaceutical and cosmetic industry. Besides, selected cultivars could be used in breeding programs, for creating new genotypes for oil production.
T2  - European Food Research and Technology
T1  - Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time
DO  - 10.1007/s00217-022-04062-3
ER  - 
@article{
author = "Koprivica, Marija and Milojković-Opsenica, Dušanka and Fotirić Akšić, Milica and Dramićanin, Aleksandra M. and Lazarević, Kristina",
year = "2022",
abstract = "The peach stones and kernels are easily available biowaste which could be useful for the extraction of nutritionally important compounds such as fatty acids. Except in industry, characterization of stones and kernels could be useful in pomology to describe different cultivars, and for selecting new parents in a breeding program. A total of 25 samples of stones and kernels from various peach cultivars that differed in origin and ripening time, but growing in the same climatic conditions, were characterized by fatty acids composition and physical properties. This work confirmed that unsaturated fatty acids (oleic and linoleic fatty acids) were the most represented in peach kernel oil and their content depended of peach genotype. Additionally, the fatty acids in combination with length, weight, and moisture of peach kernels could be used as a parameter of authenticity assessment. This research may contribute for the peach cultivar discrimination and recommendation of cultivars/genotypes with high kernel quality which could be used for the extractions of oil rich in unsaturated fatty acids and further use in food, pharmaceutical and cosmetic industry. Besides, selected cultivars could be used in breeding programs, for creating new genotypes for oil production.",
journal = "European Food Research and Technology",
title = "Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time",
doi = "10.1007/s00217-022-04062-3"
}
Koprivica, M., Milojković-Opsenica, D., Fotirić Akšić, M., Dramićanin, A. M.,& Lazarević, K.. (2022). Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time. in European Food Research and Technology.
https://doi.org/10.1007/s00217-022-04062-3
Koprivica M, Milojković-Opsenica D, Fotirić Akšić M, Dramićanin AM, Lazarević K. Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time. in European Food Research and Technology. 2022;.
doi:10.1007/s00217-022-04062-3 .
Koprivica, Marija, Milojković-Opsenica, Dušanka, Fotirić Akšić, Milica, Dramićanin, Aleksandra M., Lazarević, Kristina, "Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time" in European Food Research and Technology (2022),
https://doi.org/10.1007/s00217-022-04062-3 . .

Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2

Perić, Ivana; Lješević, Marija; Beškoski, Vladimir P.; Nikolić, Milan; Filipović, Dragana

(2022)

TY  - DATA
AU  - Perić, Ivana
AU  - Lješević, Marija
AU  - Beškoski, Vladimir P.
AU  - Nikolić, Milan
AU  - Filipović, Dragana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5499
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5500
AB  - Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.
T2  - Psychopharmacology
T1  - Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5500
ER  - 
@misc{
author = "Perić, Ivana and Lješević, Marija and Beškoski, Vladimir P. and Nikolić, Milan and Filipović, Dragana",
year = "2022",
abstract = "Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.",
journal = "Psychopharmacology",
title = "Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5500"
}
Perić, I., Lješević, M., Beškoski, V. P., Nikolić, M.,& Filipović, D.. (2022). Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2. in Psychopharmacology.
https://hdl.handle.net/21.15107/rcub_cherry_5500
Perić I, Lješević M, Beškoski VP, Nikolić M, Filipović D. Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2. in Psychopharmacology. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_5500 .
Perić, Ivana, Lješević, Marija, Beškoski, Vladimir P., Nikolić, Milan, Filipović, Dragana, "Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2" in Psychopharmacology (2022),
https://hdl.handle.net/21.15107/rcub_cherry_5500 .

Electronic cigarette liquids impair metabolic cooperation and alter proteomic profiles in V79 cells

Trifunović, Sara; Smiljanić, Katarina; Sickmann, Albert; Solari, Fiorella Andrea; Kolarević, Stoimir; Divac Rankov, Aleksandra; Ljujic, Mila

(BMC Springer Nature, 2022)

TY  - JOUR
AU  - Trifunović, Sara
AU  - Smiljanić, Katarina
AU  - Sickmann, Albert
AU  - Solari, Fiorella Andrea
AU  - Kolarević, Stoimir
AU  - Divac Rankov, Aleksandra
AU  - Ljujic, Mila
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5458
AB  - Abstract
Background: Although still considered a safer alternative to classical cigarettes, growing body of work points to
harmful effects of electronic cigarettes (e-cigarettes) affecting a range of cellular processes. The biological effect of
e-cigarettes needs to be investigated in more detail considering their widespread use.
Methods: In this study, we treated V79 lung fibroblasts with sub-cytotoxic concentration of e-cigarette liquids, with
and without nicotine. Mutagenicity was evaluated by HPRT assay, genotoxicity by comet assay and the effect on cel-
lular communication by metabolic cooperation assay. Additionally, comprehensive proteome analysis was performed
via high resolution, parallel accumulation serial fragmentation-PASEF mass spectrometry.
Results: E-cigarette liquid concentration used in this study showed no mutagenic or genotoxic effect, however it
negatively impacted metabolic cooperation between V79 cells. Both e-cigarette liquids induced significant depletion
in total number of proteins and impairment of mitochondrial function in treated cells. The focal adhesion proteins
were upregulated, which is in accordance with the results of metabolic cooperation assay. Increased presence of post-
translational modifications (PTMs), including carbonylation and direct oxidative modifications, was observed. Data are
available via ProteomeXchange with identifier PXD032071.
Conclusions: Our study revealed impairment of metabolic cooperation as well as significant proteome and PTMs
alterations in V79 cells treated with e-cigarette liquid warranting future studies on e-cigarettes health impact.
PB  - BMC Springer Nature
T2  - Respiratory Research
T1  - Electronic cigarette liquids impair metabolic cooperation and alter proteomic profiles in V79 cells
VL  - 23
IS  - 191
DO  - 10.1186/s12931-022-02102-w
ER  - 
@article{
author = "Trifunović, Sara and Smiljanić, Katarina and Sickmann, Albert and Solari, Fiorella Andrea and Kolarević, Stoimir and Divac Rankov, Aleksandra and Ljujic, Mila",
year = "2022",
abstract = "Abstract
Background: Although still considered a safer alternative to classical cigarettes, growing body of work points to
harmful effects of electronic cigarettes (e-cigarettes) affecting a range of cellular processes. The biological effect of
e-cigarettes needs to be investigated in more detail considering their widespread use.
Methods: In this study, we treated V79 lung fibroblasts with sub-cytotoxic concentration of e-cigarette liquids, with
and without nicotine. Mutagenicity was evaluated by HPRT assay, genotoxicity by comet assay and the effect on cel-
lular communication by metabolic cooperation assay. Additionally, comprehensive proteome analysis was performed
via high resolution, parallel accumulation serial fragmentation-PASEF mass spectrometry.
Results: E-cigarette liquid concentration used in this study showed no mutagenic or genotoxic effect, however it
negatively impacted metabolic cooperation between V79 cells. Both e-cigarette liquids induced significant depletion
in total number of proteins and impairment of mitochondrial function in treated cells. The focal adhesion proteins
were upregulated, which is in accordance with the results of metabolic cooperation assay. Increased presence of post-
translational modifications (PTMs), including carbonylation and direct oxidative modifications, was observed. Data are
available via ProteomeXchange with identifier PXD032071.
Conclusions: Our study revealed impairment of metabolic cooperation as well as significant proteome and PTMs
alterations in V79 cells treated with e-cigarette liquid warranting future studies on e-cigarettes health impact.",
publisher = "BMC Springer Nature",
journal = "Respiratory Research",
title = "Electronic cigarette liquids impair metabolic cooperation and alter proteomic profiles in V79 cells",
volume = "23",
number = "191",
doi = "10.1186/s12931-022-02102-w"
}
Trifunović, S., Smiljanić, K., Sickmann, A., Solari, F. A., Kolarević, S., Divac Rankov, A.,& Ljujic, M.. (2022). Electronic cigarette liquids impair metabolic cooperation and alter proteomic profiles in V79 cells. in Respiratory Research
BMC Springer Nature., 23(191).
https://doi.org/10.1186/s12931-022-02102-w
Trifunović S, Smiljanić K, Sickmann A, Solari FA, Kolarević S, Divac Rankov A, Ljujic M. Electronic cigarette liquids impair metabolic cooperation and alter proteomic profiles in V79 cells. in Respiratory Research. 2022;23(191).
doi:10.1186/s12931-022-02102-w .
Trifunović, Sara, Smiljanić, Katarina, Sickmann, Albert, Solari, Fiorella Andrea, Kolarević, Stoimir, Divac Rankov, Aleksandra, Ljujic, Mila, "Electronic cigarette liquids impair metabolic cooperation and alter proteomic profiles in V79 cells" in Respiratory Research, 23, no. 191 (2022),
https://doi.org/10.1186/s12931-022-02102-w . .
9

Zn(II) complexes with thiazolyl–hydrazones: structure, intermolecular interactions, photophysical properties, computational study and anticancer activity

Araškov, Jovana B.; Višnjevac, Aleksandar; Popović, Jasminka; Blagojević, Vladimir A.; Fernandes, Henrique S.; Sousa, Sérgio F.; Novaković, Irena; Padrón, José M.; Holló, Berta Barta; Monge, Miguel; Rodríguez-Castillo, María; López-de-Luzuriaga, José M.; Filipović, Nenad R.; Todorović, Tamara R.

(2022)

TY  - JOUR
AU  - Araškov, Jovana B.
AU  - Višnjevac, Aleksandar
AU  - Popović, Jasminka
AU  - Blagojević, Vladimir A.
AU  - Fernandes, Henrique S.
AU  - Sousa, Sérgio F.
AU  - Novaković, Irena
AU  - Padrón, José M.
AU  - Holló, Berta Barta
AU  - Monge, Miguel
AU  - Rodríguez-Castillo, María
AU  - López-de-Luzuriaga, José M.
AU  - Filipović, Nenad R.
AU  - Todorović, Tamara R.
PY  - 2022
UR  - https://pubs.rsc.org/en/content/articlelanding/2022/ce/d2ce00443g
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5380
AB  - Earth-abundant, cheap and non-toxic zinc-based coordination compounds are drawing research attention as promising candidates for various applications, such as photoluminescent materials and anticancer agents. In this paper we report six zinc complexes (1–3-NO3 and 1–3-Cl) with pyridyl-based thiazolyl–hydrazone ligands, which differ in the nature of substituents at the ligands' periphery, anion type, and geometry around the metal ion. The complexes were characterized by single-crystal and powder X-ray diffraction analysis, as well as IR and NMR spectroscopy. The symmetrical complexes 2-Cl and 3-Cl, where zinc atoms are located at a two-fold axis, do not exhibit photophysical properties, unlike their asymmetrical analogs 2-NO3 and 3-NO3 with the same complex cation. Asymmetrical pentacoordinated 1-Cl and hexacoordinated 1-NO3 complexes exhibit photophysical properties. An admixture of allowed intra-ligand (1IL) and chloro (X)-to-ligand charge-transfer (1XLCT) electronic transitions is responsible for the fluorescence of the 1-Cl complex. The origin of the emission of the 1-NO3 complex is ascribed to an admixture of 3IL and ligand-to-ligand charge-transfer (3LLCT) forbidden electronic transitions, while for 3-NO3 most electronic excitations are of LLCT character. The thermal stability of the complexes is in accord with the strength of respective intermolecular interactions. The antiproliferative activity of the complexes was in the nanomolar range on some of the investigated cancer cell lines. Contrary to the increase of antiproliferative activity of the complexes in comparison to the free ligands in cancer cell lines, an acute toxicity determined in the brine shrimp assay follows the opposite trend. The overall results suggest that Zn(II) thiazoyl–hydrazone complexes have considerable potential as multifunctional materials.
T2  - CrystEngComm
T1  - Zn(II) complexes with thiazolyl–hydrazones: structure, intermolecular interactions, photophysical properties, computational study and anticancer activity
VL  - n/a
DO  - 10.1039/D2CE00443G
ER  - 
@article{
author = "Araškov, Jovana B. and Višnjevac, Aleksandar and Popović, Jasminka and Blagojević, Vladimir A. and Fernandes, Henrique S. and Sousa, Sérgio F. and Novaković, Irena and Padrón, José M. and Holló, Berta Barta and Monge, Miguel and Rodríguez-Castillo, María and López-de-Luzuriaga, José M. and Filipović, Nenad R. and Todorović, Tamara R.",
year = "2022",
abstract = "Earth-abundant, cheap and non-toxic zinc-based coordination compounds are drawing research attention as promising candidates for various applications, such as photoluminescent materials and anticancer agents. In this paper we report six zinc complexes (1–3-NO3 and 1–3-Cl) with pyridyl-based thiazolyl–hydrazone ligands, which differ in the nature of substituents at the ligands' periphery, anion type, and geometry around the metal ion. The complexes were characterized by single-crystal and powder X-ray diffraction analysis, as well as IR and NMR spectroscopy. The symmetrical complexes 2-Cl and 3-Cl, where zinc atoms are located at a two-fold axis, do not exhibit photophysical properties, unlike their asymmetrical analogs 2-NO3 and 3-NO3 with the same complex cation. Asymmetrical pentacoordinated 1-Cl and hexacoordinated 1-NO3 complexes exhibit photophysical properties. An admixture of allowed intra-ligand (1IL) and chloro (X)-to-ligand charge-transfer (1XLCT) electronic transitions is responsible for the fluorescence of the 1-Cl complex. The origin of the emission of the 1-NO3 complex is ascribed to an admixture of 3IL and ligand-to-ligand charge-transfer (3LLCT) forbidden electronic transitions, while for 3-NO3 most electronic excitations are of LLCT character. The thermal stability of the complexes is in accord with the strength of respective intermolecular interactions. The antiproliferative activity of the complexes was in the nanomolar range on some of the investigated cancer cell lines. Contrary to the increase of antiproliferative activity of the complexes in comparison to the free ligands in cancer cell lines, an acute toxicity determined in the brine shrimp assay follows the opposite trend. The overall results suggest that Zn(II) thiazoyl–hydrazone complexes have considerable potential as multifunctional materials.",
journal = "CrystEngComm",
title = "Zn(II) complexes with thiazolyl–hydrazones: structure, intermolecular interactions, photophysical properties, computational study and anticancer activity",
volume = "n/a",
doi = "10.1039/D2CE00443G"
}
Araškov, J. B., Višnjevac, A., Popović, J., Blagojević, V. A., Fernandes, H. S., Sousa, S. F., Novaković, I., Padrón, J. M., Holló, B. B., Monge, M., Rodríguez-Castillo, M., López-de-Luzuriaga, J. M., Filipović, N. R.,& Todorović, T. R.. (2022). Zn(II) complexes with thiazolyl–hydrazones: structure, intermolecular interactions, photophysical properties, computational study and anticancer activity. in CrystEngComm, n/a.
https://doi.org/10.1039/D2CE00443G
Araškov JB, Višnjevac A, Popović J, Blagojević VA, Fernandes HS, Sousa SF, Novaković I, Padrón JM, Holló BB, Monge M, Rodríguez-Castillo M, López-de-Luzuriaga JM, Filipović NR, Todorović TR. Zn(II) complexes with thiazolyl–hydrazones: structure, intermolecular interactions, photophysical properties, computational study and anticancer activity. in CrystEngComm. 2022;n/a.
doi:10.1039/D2CE00443G .
Araškov, Jovana B., Višnjevac, Aleksandar, Popović, Jasminka, Blagojević, Vladimir A., Fernandes, Henrique S., Sousa, Sérgio F., Novaković, Irena, Padrón, José M., Holló, Berta Barta, Monge, Miguel, Rodríguez-Castillo, María, López-de-Luzuriaga, José M., Filipović, Nenad R., Todorović, Tamara R., "Zn(II) complexes with thiazolyl–hydrazones: structure, intermolecular interactions, photophysical properties, computational study and anticancer activity" in CrystEngComm, n/a (2022),
https://doi.org/10.1039/D2CE00443G . .
5
1

4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease

Komatović, Katarina; Matošević, Ana; Terzić-Jovanović, Nataša; Žunec, Suzana; Šegan, Sandra; Zlatović, Mario; Maraković, Nikola; Bosak, Anita; Opsenica, Dejan

(MDPI, 2022)

TY  - JOUR
AU  - Komatović, Katarina
AU  - Matošević, Ana
AU  - Terzić-Jovanović, Nataša
AU  - Žunec, Suzana
AU  - Šegan, Sandra
AU  - Zlatović, Mario
AU  - Maraković, Nikola
AU  - Bosak, Anita
AU  - Opsenica, Dejan
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5381
AB  - Considering that acetylcholinesterase (AChE) inhibition is the most important mode of action expected of a potential drug used for the treatment of symptoms of Alzheimer’s disease (AD), our previous pilot study of 4-aminoquinolines as potential human cholinesterase inhibitors was extended to twenty-two new structurally distinct 4-aminoquinolines bearing an adamantane moiety. Inhibition studies revealed that all of the compounds were very potent inhibitors of AChE and butyrylcholinesterase (BChE), with inhibition constants (Ki) ranging between 0.075 and 25 µM. The tested compounds exhibited a modest selectivity between the two cholinesterases; the most selective for BChE was compound 14, which displayed a 10 times higher preference, while compound 19 was a 5.8 times more potent inhibitor of AChE. Most of the compounds were estimated to be able to cross the blood–brain barrier (BBB) by passive transport. Evaluation of druglikeness singled out fourteen compounds with possible oral route of administration. The tested compounds displayed modest but generally higher antioxidant activity than the structurally similar AD drug tacrine. Compound 19 showed the highest reducing power, comparable to those of standard antioxidants. Considering their simple structure, high inhibition of AChE and BChE, and ability to cross the BBB, 4-aminoquinoline-based adamantanes show promise as structural scaffolds for further design of novel central nervous system drugs. Among them, two compounds stand out: compound 5 as the most potent inhibitor of both cholinesterases with a Ki constant in low nano molar range and the potential to cross the BBB, and compound 8, which met all our requirements, including high cholinesterase inhibition, good oral bioavailability, and antioxidative effect. The QSAR model revealed that AChE and BChE inhibition was mainly influenced by the ring and topological descriptors MCD, Nnum, RP, and RSIpw3, which defined the shape, conformational flexibility, and surface properties of the molecules
PB  - MDPI
T2  - Pharmaceutics
T1  - 4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease
VL  - 14
IS  - 6
SP  - 1305
DO  - 10.3390/pharmaceutics14061305
ER  - 
@article{
author = "Komatović, Katarina and Matošević, Ana and Terzić-Jovanović, Nataša and Žunec, Suzana and Šegan, Sandra and Zlatović, Mario and Maraković, Nikola and Bosak, Anita and Opsenica, Dejan",
year = "2022",
abstract = "Considering that acetylcholinesterase (AChE) inhibition is the most important mode of action expected of a potential drug used for the treatment of symptoms of Alzheimer’s disease (AD), our previous pilot study of 4-aminoquinolines as potential human cholinesterase inhibitors was extended to twenty-two new structurally distinct 4-aminoquinolines bearing an adamantane moiety. Inhibition studies revealed that all of the compounds were very potent inhibitors of AChE and butyrylcholinesterase (BChE), with inhibition constants (Ki) ranging between 0.075 and 25 µM. The tested compounds exhibited a modest selectivity between the two cholinesterases; the most selective for BChE was compound 14, which displayed a 10 times higher preference, while compound 19 was a 5.8 times more potent inhibitor of AChE. Most of the compounds were estimated to be able to cross the blood–brain barrier (BBB) by passive transport. Evaluation of druglikeness singled out fourteen compounds with possible oral route of administration. The tested compounds displayed modest but generally higher antioxidant activity than the structurally similar AD drug tacrine. Compound 19 showed the highest reducing power, comparable to those of standard antioxidants. Considering their simple structure, high inhibition of AChE and BChE, and ability to cross the BBB, 4-aminoquinoline-based adamantanes show promise as structural scaffolds for further design of novel central nervous system drugs. Among them, two compounds stand out: compound 5 as the most potent inhibitor of both cholinesterases with a Ki constant in low nano molar range and the potential to cross the BBB, and compound 8, which met all our requirements, including high cholinesterase inhibition, good oral bioavailability, and antioxidative effect. The QSAR model revealed that AChE and BChE inhibition was mainly influenced by the ring and topological descriptors MCD, Nnum, RP, and RSIpw3, which defined the shape, conformational flexibility, and surface properties of the molecules",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease",
volume = "14",
number = "6",
pages = "1305",
doi = "10.3390/pharmaceutics14061305"
}
Komatović, K., Matošević, A., Terzić-Jovanović, N., Žunec, S., Šegan, S., Zlatović, M., Maraković, N., Bosak, A.,& Opsenica, D.. (2022). 4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease. in Pharmaceutics
MDPI., 14(6), 1305.
https://doi.org/10.3390/pharmaceutics14061305
Komatović K, Matošević A, Terzić-Jovanović N, Žunec S, Šegan S, Zlatović M, Maraković N, Bosak A, Opsenica D. 4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease. in Pharmaceutics. 2022;14(6):1305.
doi:10.3390/pharmaceutics14061305 .
Komatović, Katarina, Matošević, Ana, Terzić-Jovanović, Nataša, Žunec, Suzana, Šegan, Sandra, Zlatović, Mario, Maraković, Nikola, Bosak, Anita, Opsenica, Dejan, "4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease" in Pharmaceutics, 14, no. 6 (2022):1305,
https://doi.org/10.3390/pharmaceutics14061305 . .
7

Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants

Kop, Tatjana; Bjelaković, Mira S.; Živković, Ljiljana S.; Žekić, Andrijana; Milić, Dragana

(Elsevier, 2022)

TY  - JOUR
AU  - Kop, Tatjana
AU  - Bjelaković, Mira S.
AU  - Živković, Ljiljana S.
AU  - Žekić, Andrijana
AU  - Milić, Dragana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5319
AB  - Despite many advantages, the practical application of fullerene C60 and curcumin (CUR) has been limited by their hydrophobic nature, deficient solubility in aqueous media and, therefore, poor bioavailability. In this study, aqueous nanoformulations containing C60 and CUR in the absence and presence of three solubility enhancers, β-cyclodextrin (CD), Tween 80 (T80) and polyvinylpyrrolidone (PVP), were prepared and subjected to the antioxidant activity assessment. The content of C60 and CUR, stability, size and morphology of nanoparticles were determined using UV–vis, DLS and SEM techniques. Contrary to better solubility of pure C60 than the corresponding C60-CUR system, the solubilization of CUR in hybrid suspensions was improved compared to corresponding pure CUR suspensions, with the exception of the C60-CUR-PVP formulation. The DLS results revealed nearly monodisperse nature of CUR-T80 nanoformulation, while other ones ranged from widely dispersed to polydispersed. Depending on the type of solubilizer, similarity was observed in the particle size distributions of T80- and PVP-coated nanoformulations as well as water and CD nanoformulations. The presence of T80 differently and significantly reduces the particle size in all three nanoformulations, while PVP slightly reduces CUR-based nanoparticles but increases the size of C60 nanoparticles. Zeta potential values, ranging from − 9 mV to − 34 mV, show variation in the starting stability of nanoparticles, from unstable or relatively stable three PVP formulations and C60-T80 to highly stable CUR-T80 and C60-water. Compared to water nanoformulations as a control, SEM images of dispersant-coated nanoparticles lost the visible morphology of active components, showing variation in their morphology depending on the type of dispersant and active component used. Nanoformulations containing CUR in PVP and T80 expressed a very good antioxidant potential in DPPH radical scavenging assay, much stronger than ascorbic acid. At the same time, a moderate to high antioxidant activity in β-carotene bleaching assay was reached in PVP and T80 nanoformulations containing C60, CUR, and their noncovalent hybrid, as well. Our studies have shown that T80 and PVP colloidal systems containing C60-CUR hybrid, but also their individual components, can be used as stable antioxidant nanoformulations with potential application in the field of food and pharmacology.
PB  - Elsevier
T2  - Colloids and Surfaces A: Physicochemical and Engineering Aspects
T1  - Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants
VL  - 648
DO  - 10.1016/j.colsurfa.2022.129379
ER  - 
@article{
author = "Kop, Tatjana and Bjelaković, Mira S. and Živković, Ljiljana S. and Žekić, Andrijana and Milić, Dragana",
year = "2022",
abstract = "Despite many advantages, the practical application of fullerene C60 and curcumin (CUR) has been limited by their hydrophobic nature, deficient solubility in aqueous media and, therefore, poor bioavailability. In this study, aqueous nanoformulations containing C60 and CUR in the absence and presence of three solubility enhancers, β-cyclodextrin (CD), Tween 80 (T80) and polyvinylpyrrolidone (PVP), were prepared and subjected to the antioxidant activity assessment. The content of C60 and CUR, stability, size and morphology of nanoparticles were determined using UV–vis, DLS and SEM techniques. Contrary to better solubility of pure C60 than the corresponding C60-CUR system, the solubilization of CUR in hybrid suspensions was improved compared to corresponding pure CUR suspensions, with the exception of the C60-CUR-PVP formulation. The DLS results revealed nearly monodisperse nature of CUR-T80 nanoformulation, while other ones ranged from widely dispersed to polydispersed. Depending on the type of solubilizer, similarity was observed in the particle size distributions of T80- and PVP-coated nanoformulations as well as water and CD nanoformulations. The presence of T80 differently and significantly reduces the particle size in all three nanoformulations, while PVP slightly reduces CUR-based nanoparticles but increases the size of C60 nanoparticles. Zeta potential values, ranging from − 9 mV to − 34 mV, show variation in the starting stability of nanoparticles, from unstable or relatively stable three PVP formulations and C60-T80 to highly stable CUR-T80 and C60-water. Compared to water nanoformulations as a control, SEM images of dispersant-coated nanoparticles lost the visible morphology of active components, showing variation in their morphology depending on the type of dispersant and active component used. Nanoformulations containing CUR in PVP and T80 expressed a very good antioxidant potential in DPPH radical scavenging assay, much stronger than ascorbic acid. At the same time, a moderate to high antioxidant activity in β-carotene bleaching assay was reached in PVP and T80 nanoformulations containing C60, CUR, and their noncovalent hybrid, as well. Our studies have shown that T80 and PVP colloidal systems containing C60-CUR hybrid, but also their individual components, can be used as stable antioxidant nanoformulations with potential application in the field of food and pharmacology.",
publisher = "Elsevier",
journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",
title = "Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants",
volume = "648",
doi = "10.1016/j.colsurfa.2022.129379"
}
Kop, T., Bjelaković, M. S., Živković, L. S., Žekić, A.,& Milić, D.. (2022). Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants. in Colloids and Surfaces A: Physicochemical and Engineering Aspects
Elsevier., 648.
https://doi.org/10.1016/j.colsurfa.2022.129379
Kop T, Bjelaković MS, Živković LS, Žekić A, Milić D. Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants. in Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2022;648.
doi:10.1016/j.colsurfa.2022.129379 .
Kop, Tatjana, Bjelaković, Mira S., Živković, Ljiljana S., Žekić, Andrijana, Milić, Dragana, "Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants" in Colloids and Surfaces A: Physicochemical and Engineering Aspects, 648 (2022),
https://doi.org/10.1016/j.colsurfa.2022.129379 . .

Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters

Marković, Sanja B.; Maciejewska, Natalia; Olszewski, Mateusz; Višnjevac, Aleksandar; Puerta, Adrián; Padrón, José M.; Novaković, Irena; Kojić, Snežana; Fernandes, Henrique S.; Sousa, Sérgio F.; Ramotowska, Sandra; Chylewska, Agnieszka; Makowski, Mariusz; Todorović, Tamara; Filipović, Nenad R.

(Elsevier, 2022)

TY  - JOUR
AU  - Marković, Sanja B.
AU  - Maciejewska, Natalia
AU  - Olszewski, Mateusz
AU  - Višnjevac, Aleksandar
AU  - Puerta, Adrián
AU  - Padrón, José M.
AU  - Novaković, Irena
AU  - Kojić, Snežana
AU  - Fernandes, Henrique S.
AU  - Sousa, Sérgio F.
AU  - Ramotowska, Sandra
AU  - Chylewska, Agnieszka
AU  - Makowski, Mariusz
AU  - Todorović, Tamara
AU  - Filipović, Nenad R.
PY  - 2022
UR  - https://www.sciencedirect.com/science/article/pii/S0223523422003518
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5209
AB  - The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The paradigm of metal toxicity has been challenged suggesting that metal toxicity is not a constant property, yet it depends on many factors like the presence of appropriate ligands. Studies on anticancer activity of cadmium complexes showed that the complexation of various ligands resulted in complexes that showed better activities than approved drugs. In the present study, cadmium complexes with biologically potent thiazolyl/selenazoyl-hydrazone ligands have been prepared, and tested for their activity against different types of tumor cell models. The complexation of ligands with Cd(II) resulted in a synergistic effect. The antiproliferative activity study revealed that all complexes are more active compared to 5-fluorouracil and cisplatin. The mechanism of tumor cell growth inhibition reveal that selenium-based compounds induce cell death in T-47D (gland carcinoma) cells through apoptosis via caspase-3/7 activation. Additionally, their pro-apoptotic effect was stronger compared to etoposide and cisplatin. Nuclease activity, detected by gel electrophoresis, may be the possible mechanism of anticancer action of investigated complexes.
PB  - Elsevier
T2  - European Journal of Medicinal Chemistry
T1  - Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters
VL  - 238
SP  - 114449
DO  - 10.1016/j.ejmech.2022.114449
ER  - 
@article{
author = "Marković, Sanja B. and Maciejewska, Natalia and Olszewski, Mateusz and Višnjevac, Aleksandar and Puerta, Adrián and Padrón, José M. and Novaković, Irena and Kojić, Snežana and Fernandes, Henrique S. and Sousa, Sérgio F. and Ramotowska, Sandra and Chylewska, Agnieszka and Makowski, Mariusz and Todorović, Tamara and Filipović, Nenad R.",
year = "2022",
abstract = "The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The paradigm of metal toxicity has been challenged suggesting that metal toxicity is not a constant property, yet it depends on many factors like the presence of appropriate ligands. Studies on anticancer activity of cadmium complexes showed that the complexation of various ligands resulted in complexes that showed better activities than approved drugs. In the present study, cadmium complexes with biologically potent thiazolyl/selenazoyl-hydrazone ligands have been prepared, and tested for their activity against different types of tumor cell models. The complexation of ligands with Cd(II) resulted in a synergistic effect. The antiproliferative activity study revealed that all complexes are more active compared to 5-fluorouracil and cisplatin. The mechanism of tumor cell growth inhibition reveal that selenium-based compounds induce cell death in T-47D (gland carcinoma) cells through apoptosis via caspase-3/7 activation. Additionally, their pro-apoptotic effect was stronger compared to etoposide and cisplatin. Nuclease activity, detected by gel electrophoresis, may be the possible mechanism of anticancer action of investigated complexes.",
publisher = "Elsevier",
journal = "European Journal of Medicinal Chemistry",
title = "Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters",
volume = "238",
pages = "114449",
doi = "10.1016/j.ejmech.2022.114449"
}
Marković, S. B., Maciejewska, N., Olszewski, M., Višnjevac, A., Puerta, A., Padrón, J. M., Novaković, I., Kojić, S., Fernandes, H. S., Sousa, S. F., Ramotowska, S., Chylewska, A., Makowski, M., Todorović, T.,& Filipović, N. R.. (2022). Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters. in European Journal of Medicinal Chemistry
Elsevier., 238, 114449.
https://doi.org/10.1016/j.ejmech.2022.114449
Marković SB, Maciejewska N, Olszewski M, Višnjevac A, Puerta A, Padrón JM, Novaković I, Kojić S, Fernandes HS, Sousa SF, Ramotowska S, Chylewska A, Makowski M, Todorović T, Filipović NR. Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters. in European Journal of Medicinal Chemistry. 2022;238:114449.
doi:10.1016/j.ejmech.2022.114449 .
Marković, Sanja B., Maciejewska, Natalia, Olszewski, Mateusz, Višnjevac, Aleksandar, Puerta, Adrián, Padrón, José M., Novaković, Irena, Kojić, Snežana, Fernandes, Henrique S., Sousa, Sérgio F., Ramotowska, Sandra, Chylewska, Agnieszka, Makowski, Mariusz, Todorović, Tamara, Filipović, Nenad R., "Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters" in European Journal of Medicinal Chemistry, 238 (2022):114449,
https://doi.org/10.1016/j.ejmech.2022.114449 . .
11
1
1
1

Terpene relationships among some soft and hard pine species

Krstić, Gordana B.; Nikolić, Biljana; Todosijević, Marina; Mitić, Zorica S.; Stanković-Jeremić, Jovana; Cvetković, Mirjana; Bojović, Srđan R.; Marin, Petar D.

(2022)

TY  - JOUR
AU  - Krstić, Gordana B.
AU  - Nikolić, Biljana
AU  - Todosijević, Marina
AU  - Mitić, Zorica S.
AU  - Stanković-Jeremić, Jovana
AU  - Cvetković, Mirjana
AU  - Bojović, Srđan R.
AU  - Marin, Petar D.
PY  - 2022
UR  - http://www.doiserbia.nb.rs/Article.aspx?ID=1821-21582201039K
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5180
AB  - In this study we have reported the chemical composition of the essential oils obtained from the needles of twelve Pinus taxa, belonging to the subgenera Pinus (sections Pinus and Trifoliae) and Strobus (sect. Quinquefoliae). Monoterpenes dominated over sesquiterpenes in most of the investigated taxa of both subgenera, except in representatives of the subsection Pinaster, subgenus Pinus. α-Pinene was the most abundant terpene in eight pines, but other dominant terpenes were found in some taxa - trans-caryophyllene, germacrene D, abietadiene and β-pinene. In the subsect. Pinaster, the most dominant compounds varied from species to species. In addition, P. halepensis and P. pinaster had the highest percentage of diterpenes, while P. heldreichii was the richest in germacrene D. In the PCA and cluster analyses, three species from the subsect. Pinaster emerged as the most distant: P. halepensis, P. pinaster, and P. heldreichii. In addition, the possible taxonomic implications of the terpene profile in the analysed Pinus taxa were also discussed.
T2  - Botanica Serbica
T1  - Terpene relationships among some soft and hard pine species
VL  - 46
IS  - 1
SP  - 39
EP  - 48
DO  - 10.2298/BOTSERB2201039K
ER  - 
@article{
author = "Krstić, Gordana B. and Nikolić, Biljana and Todosijević, Marina and Mitić, Zorica S. and Stanković-Jeremić, Jovana and Cvetković, Mirjana and Bojović, Srđan R. and Marin, Petar D.",
year = "2022",
abstract = "In this study we have reported the chemical composition of the essential oils obtained from the needles of twelve Pinus taxa, belonging to the subgenera Pinus (sections Pinus and Trifoliae) and Strobus (sect. Quinquefoliae). Monoterpenes dominated over sesquiterpenes in most of the investigated taxa of both subgenera, except in representatives of the subsection Pinaster, subgenus Pinus. α-Pinene was the most abundant terpene in eight pines, but other dominant terpenes were found in some taxa - trans-caryophyllene, germacrene D, abietadiene and β-pinene. In the subsect. Pinaster, the most dominant compounds varied from species to species. In addition, P. halepensis and P. pinaster had the highest percentage of diterpenes, while P. heldreichii was the richest in germacrene D. In the PCA and cluster analyses, three species from the subsect. Pinaster emerged as the most distant: P. halepensis, P. pinaster, and P. heldreichii. In addition, the possible taxonomic implications of the terpene profile in the analysed Pinus taxa were also discussed.",
journal = "Botanica Serbica",
title = "Terpene relationships among some soft and hard pine species",
volume = "46",
number = "1",
pages = "39-48",
doi = "10.2298/BOTSERB2201039K"
}
Krstić, G. B., Nikolić, B., Todosijević, M., Mitić, Z. S., Stanković-Jeremić, J., Cvetković, M., Bojović, S. R.,& Marin, P. D.. (2022). Terpene relationships among some soft and hard pine species. in Botanica Serbica, 46(1), 39-48.
https://doi.org/10.2298/BOTSERB2201039K
Krstić GB, Nikolić B, Todosijević M, Mitić ZS, Stanković-Jeremić J, Cvetković M, Bojović SR, Marin PD. Terpene relationships among some soft and hard pine species. in Botanica Serbica. 2022;46(1):39-48.
doi:10.2298/BOTSERB2201039K .
Krstić, Gordana B., Nikolić, Biljana, Todosijević, Marina, Mitić, Zorica S., Stanković-Jeremić, Jovana, Cvetković, Mirjana, Bojović, Srđan R., Marin, Petar D., "Terpene relationships among some soft and hard pine species" in Botanica Serbica, 46, no. 1 (2022):39-48,
https://doi.org/10.2298/BOTSERB2201039K . .
1

Total Synthesis of ( + )-Swainsonine, (–)- Swainsonine, ( + )-8-epi-Swainsonine and ( + )- Dideoxy-Imino-Lyxitol by an Organocatalyzed Aldolization/Reductive Amination Sequence

Trajković, Miloš D.; Pavlović, Miloš; Bihelović, Filip; Ferjančić, Zorana; Saičić, Radomir

(2022)

TY  - JOUR
AU  - Trajković, Miloš D.
AU  - Pavlović, Miloš
AU  - Bihelović, Filip
AU  - Ferjančić, Zorana
AU  - Saičić, Radomir
PY  - 2022
UR  - https://doi.org/10.1177/1934578X221091672
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5179
AB  - A tactical combination of either (S)- or (R)-proline catalyzed aldol reaction followed by intramolecular reductive amination enabled the synthesis of a chiral pyrrolidine derivative with 3 contiguous stereocenters in only 2 synthetic steps, starting from achiral precursors. This product, obtainable in both enantiomeric forms, was further exploited as a common intermediate in total syntheses of the biologically active iminosugars: ( + )-swainsonine, (–)-swainsonine, ( + )-8-epi-swainsonine, and ( + )-dideoxy-imino-lyxitol.
T2  - Natural Product Communications
T2  - Natural Product CommunicationsNatural Product Communications
T1  - Total Synthesis of ( + )-Swainsonine, (–)- Swainsonine, ( + )-8-epi-Swainsonine and ( + )- Dideoxy-Imino-Lyxitol by an Organocatalyzed Aldolization/Reductive Amination Sequence
VL  - 17
IS  - 4
DO  - 10.1177/1934578X221091672
ER  - 
@article{
author = "Trajković, Miloš D. and Pavlović, Miloš and Bihelović, Filip and Ferjančić, Zorana and Saičić, Radomir",
year = "2022",
abstract = "A tactical combination of either (S)- or (R)-proline catalyzed aldol reaction followed by intramolecular reductive amination enabled the synthesis of a chiral pyrrolidine derivative with 3 contiguous stereocenters in only 2 synthetic steps, starting from achiral precursors. This product, obtainable in both enantiomeric forms, was further exploited as a common intermediate in total syntheses of the biologically active iminosugars: ( + )-swainsonine, (–)-swainsonine, ( + )-8-epi-swainsonine, and ( + )-dideoxy-imino-lyxitol.",
journal = "Natural Product Communications, Natural Product CommunicationsNatural Product Communications",
title = "Total Synthesis of ( + )-Swainsonine, (–)- Swainsonine, ( + )-8-epi-Swainsonine and ( + )- Dideoxy-Imino-Lyxitol by an Organocatalyzed Aldolization/Reductive Amination Sequence",
volume = "17",
number = "4",
doi = "10.1177/1934578X221091672"
}
Trajković, M. D., Pavlović, M., Bihelović, F., Ferjančić, Z.,& Saičić, R.. (2022). Total Synthesis of ( + )-Swainsonine, (–)- Swainsonine, ( + )-8-epi-Swainsonine and ( + )- Dideoxy-Imino-Lyxitol by an Organocatalyzed Aldolization/Reductive Amination Sequence. in Natural Product Communications, 17(4).
https://doi.org/10.1177/1934578X221091672
Trajković MD, Pavlović M, Bihelović F, Ferjančić Z, Saičić R. Total Synthesis of ( + )-Swainsonine, (–)- Swainsonine, ( + )-8-epi-Swainsonine and ( + )- Dideoxy-Imino-Lyxitol by an Organocatalyzed Aldolization/Reductive Amination Sequence. in Natural Product Communications. 2022;17(4).
doi:10.1177/1934578X221091672 .
Trajković, Miloš D., Pavlović, Miloš, Bihelović, Filip, Ferjančić, Zorana, Saičić, Radomir, "Total Synthesis of ( + )-Swainsonine, (–)- Swainsonine, ( + )-8-epi-Swainsonine and ( + )- Dideoxy-Imino-Lyxitol by an Organocatalyzed Aldolization/Reductive Amination Sequence" in Natural Product Communications, 17, no. 4 (2022),
https://doi.org/10.1177/1934578X221091672 . .

Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems

Fotirić-Akšić, Milica M.; Dabić-Zagorac, Dragana; Gašić, Uroš M.; Tosti, Tomislav; Natić, Maja; Meland, Mekjell

(MDPI, 2022)

TY  - JOUR
AU  - Fotirić-Akšić, Milica M.
AU  - Dabić-Zagorac, Dragana
AU  - Gašić, Uroš M.
AU  - Tosti, Tomislav
AU  - Natić, Maja
AU  - Meland, Mekjell
PY  - 2022
UR  - https://www.mdpi.com/2071-1050/14/9/5300
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5178
AB  - The aim of this study was to compare total phenolic content (TPC), radical-scavenging activity (RSA), total anthocyanin content (TAC), sugar and polyphenolic profiles of two apple cultivars (‘Discovery’ and ‘Red Aroma Orelind’) from organic and integrated production systems in climatic conditions of Western Norway. Sixteen sugars and four sugar alcohols and 19 polyphenols were found in the peel, but less polyphenols were detected in the pulp. The peel of both apples and in both production systems had significantly higher TPC and RSA than the pulp. The peel from integrated apples had higher TPC than the peel from organic apples, while organic apples had higher TAC than the integrated. Sucrose and glucose levels were higher in organic apples; fructose was cultivar dependent while minor sugars were higher in integrated fruits. The most abundant polyphenolic compound in the peel of the tested cultivars was quercetin 3-O-galactoside, while chlorogenic acid was most abundant in the pulp. Regarding polyphenols, phloretin, phloridzin, protocatechuic acid, baicalein and naringenin were higher in organic apple, while quercetin 3-O-galactoside, kaempferol 3-O-glucoside, chlorogenic acid and syringic acid was higher in integrated fruits. In conclusion, organic ‘Discovery’ and integrated ‘Red Aroma Orelind’ had higher bioavailability of health related compounds from the peel and the pulp.
PB  - MDPI
T2  - Sustainability
T2  - Sustainability
T1  - Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems
VL  - 14
IS  - 9
SP  - 5300
DO  - 10.3390/su14095300
ER  - 
@article{
author = "Fotirić-Akšić, Milica M. and Dabić-Zagorac, Dragana and Gašić, Uroš M. and Tosti, Tomislav and Natić, Maja and Meland, Mekjell",
year = "2022",
abstract = "The aim of this study was to compare total phenolic content (TPC), radical-scavenging activity (RSA), total anthocyanin content (TAC), sugar and polyphenolic profiles of two apple cultivars (‘Discovery’ and ‘Red Aroma Orelind’) from organic and integrated production systems in climatic conditions of Western Norway. Sixteen sugars and four sugar alcohols and 19 polyphenols were found in the peel, but less polyphenols were detected in the pulp. The peel of both apples and in both production systems had significantly higher TPC and RSA than the pulp. The peel from integrated apples had higher TPC than the peel from organic apples, while organic apples had higher TAC than the integrated. Sucrose and glucose levels were higher in organic apples; fructose was cultivar dependent while minor sugars were higher in integrated fruits. The most abundant polyphenolic compound in the peel of the tested cultivars was quercetin 3-O-galactoside, while chlorogenic acid was most abundant in the pulp. Regarding polyphenols, phloretin, phloridzin, protocatechuic acid, baicalein and naringenin were higher in organic apple, while quercetin 3-O-galactoside, kaempferol 3-O-glucoside, chlorogenic acid and syringic acid was higher in integrated fruits. In conclusion, organic ‘Discovery’ and integrated ‘Red Aroma Orelind’ had higher bioavailability of health related compounds from the peel and the pulp.",
publisher = "MDPI",
journal = "Sustainability, Sustainability",
title = "Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems",
volume = "14",
number = "9",
pages = "5300",
doi = "10.3390/su14095300"
}
Fotirić-Akšić, M. M., Dabić-Zagorac, D., Gašić, U. M., Tosti, T., Natić, M.,& Meland, M.. (2022). Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems. in Sustainability
MDPI., 14(9), 5300.
https://doi.org/10.3390/su14095300
Fotirić-Akšić MM, Dabić-Zagorac D, Gašić UM, Tosti T, Natić M, Meland M. Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems. in Sustainability. 2022;14(9):5300.
doi:10.3390/su14095300 .
Fotirić-Akšić, Milica M., Dabić-Zagorac, Dragana, Gašić, Uroš M., Tosti, Tomislav, Natić, Maja, Meland, Mekjell, "Analysis of Apple Fruit (Malus × domestica Borkh.) Quality Attributes Obtained from Organic and Integrated Production Systems" in Sustainability, 14, no. 9 (2022):5300,
https://doi.org/10.3390/su14095300 . .
1
2
2
2

Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer

Filipović, Lidija; Spasojević, Milica; Prodanović, Radivoje; Korać, Aleksandra; Matijaševic, Suzana; Brajušković, Goran; de Marco, Ario; Popović, Milica

(Elsevier, 2022)

TY  - JOUR
AU  - Filipović, Lidija
AU  - Spasojević, Milica
AU  - Prodanović, Radivoje
AU  - Korać, Aleksandra
AU  - Matijaševic, Suzana
AU  - Brajušković, Goran
AU  - de Marco, Ario
AU  - Popović, Milica
PY  - 2022
UR  - https://pubmed.ncbi.nlm.nih.gov/35301156/
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5152
AB  - Correct elucidation of physiological and pathological processes mediated by extracellular vesicles (EV) is highly dependent on the reliability of the method used for their purification. Currently available chemical/physical protocols for sample fractionation are time-consuming, often scarcely reproducible and their yields are low. Immuno-capture based approaches could represent an effective purification alternative to obtain homogeneous EV samples. An easy-to-operate chromatography system was set-up for the purification of intact EVs based on a single domain (VHH) antibodies-copolymer matrix suitable for biological samples as different as conditioned cell culture medium and human plasma. Methacrylate-based copolymer is a porous solid support, the chemical versatility of which enables its efficient functionalization with VHHs. The combined analyses of morphological features and biomarker (CD9, CD63 and CD81) presence indicated that the recovered EVs were exosomes. The lipoprotein markers APO-A1 and APO-B were both negative in tested samples. This is the first report demonstrating the successful application of spherical porous methacrylate-based copolymer coupled with VHHs for the exosome isolation from biological fluids. This inexpensive immunoaffinity method has the potential to be applied for the isolation of EVs belonging to different morphological and physiological classes.
PB  - Elsevier
T2  - New Biotechnology
T1  - Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer
VL  - 69
SP  - 36
EP  - 48
DO  - 10.1016/j.nbt.2022.03.001
ER  - 
@article{
author = "Filipović, Lidija and Spasojević, Milica and Prodanović, Radivoje and Korać, Aleksandra and Matijaševic, Suzana and Brajušković, Goran and de Marco, Ario and Popović, Milica",
year = "2022",
abstract = "Correct elucidation of physiological and pathological processes mediated by extracellular vesicles (EV) is highly dependent on the reliability of the method used for their purification. Currently available chemical/physical protocols for sample fractionation are time-consuming, often scarcely reproducible and their yields are low. Immuno-capture based approaches could represent an effective purification alternative to obtain homogeneous EV samples. An easy-to-operate chromatography system was set-up for the purification of intact EVs based on a single domain (VHH) antibodies-copolymer matrix suitable for biological samples as different as conditioned cell culture medium and human plasma. Methacrylate-based copolymer is a porous solid support, the chemical versatility of which enables its efficient functionalization with VHHs. The combined analyses of morphological features and biomarker (CD9, CD63 and CD81) presence indicated that the recovered EVs were exosomes. The lipoprotein markers APO-A1 and APO-B were both negative in tested samples. This is the first report demonstrating the successful application of spherical porous methacrylate-based copolymer coupled with VHHs for the exosome isolation from biological fluids. This inexpensive immunoaffinity method has the potential to be applied for the isolation of EVs belonging to different morphological and physiological classes.",
publisher = "Elsevier",
journal = "New Biotechnology",
title = "Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer",
volume = "69",
pages = "36-48",
doi = "10.1016/j.nbt.2022.03.001"
}
Filipović, L., Spasojević, M., Prodanović, R., Korać, A., Matijaševic, S., Brajušković, G., de Marco, A.,& Popović, M.. (2022). Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer. in New Biotechnology
Elsevier., 69, 36-48.
https://doi.org/10.1016/j.nbt.2022.03.001
Filipović L, Spasojević M, Prodanović R, Korać A, Matijaševic S, Brajušković G, de Marco A, Popović M. Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer. in New Biotechnology. 2022;69:36-48.
doi:10.1016/j.nbt.2022.03.001 .
Filipović, Lidija, Spasojević, Milica, Prodanović, Radivoje, Korać, Aleksandra, Matijaševic, Suzana, Brajušković, Goran, de Marco, Ario, Popović, Milica, "Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer" in New Biotechnology, 69 (2022):36-48,
https://doi.org/10.1016/j.nbt.2022.03.001 . .
1
1

Thin-layer chromatography in the authenticity testing of bee-products

Milojković-Opsenica, Dušanka; Trifković, Jelena; Ristivojević, Petar; Andrić, Filip

(Elsevier, 2022)

TY  - JOUR
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
AU  - Ristivojević, Petar
AU  - Andrić, Filip
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4999
AB  - Quality control, nutritional value and the monitoring of hazardous residues in honey bee- products have become
major topics for both producers and consumers. Due to its potential role in human health, bee-products rich in
bioactive compounds are becoming increasingly popular. This review aims to provide an overview of thin-layer
chromatography methods used in quality control, authenticity testing and chemical profiling of bee-products in
order to help scientists engaged in the field of bee-products chemistry to utilize the advantages of this technique
in the detection and elimination of fraudulent practices in bee-product manufacturing. Recently, hyphenation of
thin-layer chromatography, image analysis and chemometrics support bee-products analysis by simultaneous determination of analytes with different detection principles, identification of individual
bioactive compounds as well as structure elucidation of compounds. Highlighted opportunities of thin-layer
chromatography could encourage further investigations that would lead to improvements in the detection and
elimination of marketing fraudulent practices.
PB  - Elsevier
T2  - Journal of Chromatography B
T1  - Thin-layer chromatography in the authenticity testing of bee-products
VL  - 1188
IS  - 123068
DO  - 10.1016/j.jchromb.2021.123068
ER  - 
@article{
author = "Milojković-Opsenica, Dušanka and Trifković, Jelena and Ristivojević, Petar and Andrić, Filip",
year = "2022",
abstract = "Quality control, nutritional value and the monitoring of hazardous residues in honey bee- products have become
major topics for both producers and consumers. Due to its potential role in human health, bee-products rich in
bioactive compounds are becoming increasingly popular. This review aims to provide an overview of thin-layer
chromatography methods used in quality control, authenticity testing and chemical profiling of bee-products in
order to help scientists engaged in the field of bee-products chemistry to utilize the advantages of this technique
in the detection and elimination of fraudulent practices in bee-product manufacturing. Recently, hyphenation of
thin-layer chromatography, image analysis and chemometrics support bee-products analysis by simultaneous determination of analytes with different detection principles, identification of individual
bioactive compounds as well as structure elucidation of compounds. Highlighted opportunities of thin-layer
chromatography could encourage further investigations that would lead to improvements in the detection and
elimination of marketing fraudulent practices.",
publisher = "Elsevier",
journal = "Journal of Chromatography B",
title = "Thin-layer chromatography in the authenticity testing of bee-products",
volume = "1188",
number = "123068",
doi = "10.1016/j.jchromb.2021.123068"
}
Milojković-Opsenica, D., Trifković, J., Ristivojević, P.,& Andrić, F.. (2022). Thin-layer chromatography in the authenticity testing of bee-products. in Journal of Chromatography B
Elsevier., 1188(123068).
https://doi.org/10.1016/j.jchromb.2021.123068
Milojković-Opsenica D, Trifković J, Ristivojević P, Andrić F. Thin-layer chromatography in the authenticity testing of bee-products. in Journal of Chromatography B. 2022;1188(123068).
doi:10.1016/j.jchromb.2021.123068 .
Milojković-Opsenica, Dušanka, Trifković, Jelena, Ristivojević, Petar, Andrić, Filip, "Thin-layer chromatography in the authenticity testing of bee-products" in Journal of Chromatography B, 1188, no. 123068 (2022),
https://doi.org/10.1016/j.jchromb.2021.123068 . .
1
3
3
3

Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens

Nikolić, Biljana M.; Milanović, Slobodan D.; Milenković, Ivan Lj.; Todosijević, Marina; Đorđević, Iris Ž.; Brkić, Milana Z.; Mitić, Zorica S.; Marin, Petar D.; Tešević, Vele

(Elsevier, 2022)

TY  - JOUR
AU  - Nikolić, Biljana M.
AU  - Milanović, Slobodan D.
AU  - Milenković, Ivan Lj.
AU  - Todosijević, Marina
AU  - Đorđević, Iris Ž.
AU  - Brkić, Milana Z.
AU  - Mitić, Zorica S.
AU  - Marin, Petar D.
AU  - Tešević, Vele
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4885
AB  - We examined essential oils (EOs) of Chamaecyparis lawsoniana and Thuja plicata (Cupressaceae), their antifeedant activity on Lymanthria dispar larvae and their antimicrobial activity. Studies of EOs showed that these two conifer species differed both in content of terpene classes and the major compounds. Total monoterpenes strongly dominated in T. plicata (96.4%), while C. lawsoniana was rich in both mono- and sesquiterpenes (40.8% and 30.3%, respectively) as well as in diterpenes (19.1%). The most dominant compounds of C. lawsoniana EO were: limonene (16.7%), oplopanonyl acetate (14.5%), beyerene (10.1%), and 13-epi-dolabradiene (6.7%). The dominant compound of T. plicata EOs was α-thujone (76.9%), followed by relatively small amounts of β- thujone (5.3%), sabinene (4.5%) and terpinene-4-ol (3.2%). The difference in EO compositions of the conifers was reflected on Lymantria dispar larvae performance. Larvae fed on the leaf discs treated by C. lawsoniana EO had a slight phagostimulatory effect at lower concentration shown by higher relative rate of food consumption and relative growth rate than the larvae in the control group. Contrastingly, leaf discs treated with EO of T. plicata EO had an antifeedant effect and lower relative consumption rate (RCR) and relative growth rate RGR than the larvae in the control group. Both tested EOs influenced substantially the colony growth of the subjected Phytophthora plurivora and P. quercina. Namely, 100% inhibitory effect was recorded at concentration of 0.1% in the case of C. lawsoniana EO, whereas of T. plicata colonies did not grow at 0.5% concentration. The implications of these findings and possibility of using the tested EOs in further experiments in vitro and in vivo are discussed.
PB  - Elsevier
T2  - Industrial Crops and Products
T2  - Industrial Crops and ProductsIndustrial Crops and Products
T1  - Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens
VL  - 178
SP  - 114550
DO  - 10.1016/j.indcrop.2022.114550
ER  - 
@article{
author = "Nikolić, Biljana M. and Milanović, Slobodan D. and Milenković, Ivan Lj. and Todosijević, Marina and Đorđević, Iris Ž. and Brkić, Milana Z. and Mitić, Zorica S. and Marin, Petar D. and Tešević, Vele",
year = "2022",
abstract = "We examined essential oils (EOs) of Chamaecyparis lawsoniana and Thuja plicata (Cupressaceae), their antifeedant activity on Lymanthria dispar larvae and their antimicrobial activity. Studies of EOs showed that these two conifer species differed both in content of terpene classes and the major compounds. Total monoterpenes strongly dominated in T. plicata (96.4%), while C. lawsoniana was rich in both mono- and sesquiterpenes (40.8% and 30.3%, respectively) as well as in diterpenes (19.1%). The most dominant compounds of C. lawsoniana EO were: limonene (16.7%), oplopanonyl acetate (14.5%), beyerene (10.1%), and 13-epi-dolabradiene (6.7%). The dominant compound of T. plicata EOs was α-thujone (76.9%), followed by relatively small amounts of β- thujone (5.3%), sabinene (4.5%) and terpinene-4-ol (3.2%). The difference in EO compositions of the conifers was reflected on Lymantria dispar larvae performance. Larvae fed on the leaf discs treated by C. lawsoniana EO had a slight phagostimulatory effect at lower concentration shown by higher relative rate of food consumption and relative growth rate than the larvae in the control group. Contrastingly, leaf discs treated with EO of T. plicata EO had an antifeedant effect and lower relative consumption rate (RCR) and relative growth rate RGR than the larvae in the control group. Both tested EOs influenced substantially the colony growth of the subjected Phytophthora plurivora and P. quercina. Namely, 100% inhibitory effect was recorded at concentration of 0.1% in the case of C. lawsoniana EO, whereas of T. plicata colonies did not grow at 0.5% concentration. The implications of these findings and possibility of using the tested EOs in further experiments in vitro and in vivo are discussed.",
publisher = "Elsevier",
journal = "Industrial Crops and Products, Industrial Crops and ProductsIndustrial Crops and Products",
title = "Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens",
volume = "178",
pages = "114550",
doi = "10.1016/j.indcrop.2022.114550"
}
Nikolić, B. M., Milanović, S. D., Milenković, I. Lj., Todosijević, M., Đorđević, I. Ž., Brkić, M. Z., Mitić, Z. S., Marin, P. D.,& Tešević, V.. (2022). Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens. in Industrial Crops and Products
Elsevier., 178, 114550.
https://doi.org/10.1016/j.indcrop.2022.114550
Nikolić BM, Milanović SD, Milenković IL, Todosijević M, Đorđević IŽ, Brkić MZ, Mitić ZS, Marin PD, Tešević V. Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens. in Industrial Crops and Products. 2022;178:114550.
doi:10.1016/j.indcrop.2022.114550 .
Nikolić, Biljana M., Milanović, Slobodan D., Milenković, Ivan Lj., Todosijević, Marina, Đorđević, Iris Ž., Brkić, Milana Z., Mitić, Zorica S., Marin, Petar D., Tešević, Vele, "Bioactivity of Chamaecyparis lawsoniana (A. Murray) Parl. and Thuja plicata Donn ex D. Don essential oils on Lymantria dispar (Linnaeus, 1758) (Lepidoptera: Erebidae) larvae and Phytophthora de Bary 1876 root pathogens" in Industrial Crops and Products, 178 (2022):114550,
https://doi.org/10.1016/j.indcrop.2022.114550 . .