TY  - JOUR
AU  - Jovanović-Novak, Ivana
AU  - Komorsky-Lovrić, Šebojka
AU  - Lucić-Vrdoljak, Ana
AU  - Popović, Aleksandar R.
AU  - Neuberg, Marijana
PY  - 2018
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2092
AB  - Electrochemical reduction of irinotecan was investigated on a static mercury drop electrode using square-wave voltammetry. The mechanism of irinotecan electroreduction is a complex, pH-dependent, quasireversible process and includes the transfer of two electrons and two protons. In acidic medium, the first electron transfer reaction is followed by the chemical reaction, and the product of this chemical reaction undergoes further electrochemical reduction at more negative potentials. Both irinotecan and the product of its reduction adsorb on the mercury electrode surface. Based on the adsorptive character of irinotecan, a new adsorptive stripping square-wave voltammetric method for its electroanalytical determination has been proposed. The voltammetric response could be used to determine irinotecan in the concentration range from 1x10(-7)mol/L to 1.5x10(-6)mol/L and from 5x10(-9)mol/L to 1.2x10(-7)mol/L, if the accumulation time is 20s and 300s, respectively. The calculated limit of detection for irinotecan was found to be 8.7x10(-9)mol/L (if t(acc)=300s).
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Electroanalysis
T1  - Voltammetric Characterisation of Anticancer Drug Irinotecan
VL  - 30
IS  - 2
SP  - 336
EP  - 344
DO  - 10.1002/elan.201700593
ER  - 

@article{
author = "Jovanović-Novak, Ivana and Komorsky-Lovrić, Šebojka and Lucić-Vrdoljak, Ana and Popović, Aleksandar R. and Neuberg, Marijana",
year = "2018",
abstract = "Electrochemical reduction of irinotecan was investigated on a static mercury drop electrode using square-wave voltammetry. The mechanism of irinotecan electroreduction is a complex, pH-dependent, quasireversible process and includes the transfer of two electrons and two protons. In acidic medium, the first electron transfer reaction is followed by the chemical reaction, and the product of this chemical reaction undergoes further electrochemical reduction at more negative potentials. Both irinotecan and the product of its reduction adsorb on the mercury electrode surface. Based on the adsorptive character of irinotecan, a new adsorptive stripping square-wave voltammetric method for its electroanalytical determination has been proposed. The voltammetric response could be used to determine irinotecan in the concentration range from 1x10(-7)mol/L to 1.5x10(-6)mol/L and from 5x10(-9)mol/L to 1.2x10(-7)mol/L, if the accumulation time is 20s and 300s, respectively. The calculated limit of detection for irinotecan was found to be 8.7x10(-9)mol/L (if t(acc)=300s).",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Electroanalysis",
title = "Voltammetric Characterisation of Anticancer Drug Irinotecan",
volume = "30",
number = "2",
pages = "336-344",
doi = "10.1002/elan.201700593"
}

Jovanović-Novak, I., Komorsky-Lovrić, Š., Lucić-Vrdoljak, A., Popović, A. R.,& Neuberg, M.. (2018). Voltammetric Characterisation of Anticancer Drug Irinotecan. in Electroanalysis
Wiley-V C H Verlag Gmbh, Weinheim., 30(2), 336-344.
https://doi.org/10.1002/elan.201700593

Jovanović-Novak I, Komorsky-Lovrić Š, Lucić-Vrdoljak A, Popović AR, Neuberg M. Voltammetric Characterisation of Anticancer Drug Irinotecan. in Electroanalysis. 2018;30(2):336-344.
doi:10.1002/elan.201700593 .

Jovanović-Novak, Ivana, Komorsky-Lovrić, Šebojka, Lucić-Vrdoljak, Ana, Popović, Aleksandar R., Neuberg, Marijana, "Voltammetric Characterisation of Anticancer Drug Irinotecan" in Electroanalysis, 30, no. 2 (2018):336-344,
https://doi.org/10.1002/elan.201700593 . .