Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM)

Link to this page

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Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (en)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 451-03-68/2020-14/200026 (Univerzitet u Beogradu, Institut za hemiju, tehnologiju i metalurgiju - IHTM) (sr_RS)
Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 451-03-68/2020-14/200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (sr)
Authors

Publications

Metabolomics study of the desiccation and recovery process in the resurrection plants Ramonda serbica and R. nathaliae

Gođevac, Dejan; Ivanović, Stefan; Simić, Katarina; Anđelković, Boban D.; Jovanović, Živko S.; Rakić, Tamara

TY  - JOUR
AU  - Gođevac, Dejan
AU  - Ivanović, Stefan
AU  - Simić, Katarina
AU  - Anđelković, Boban D.
AU  - Jovanović, Živko S.
AU  - Rakić, Tamara
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/pca.3151
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5417
AB  - Introduction Ramonda serbica and R. nathaliae are resurrection plants that have the remarkable ability to survive the complete desiccation of their vegetative organs (i.e. leaves, stem, roots) during periods of drought and rapidly revive when rewatered and rehydrated. Objective To investigate metabolic changes in R. serbica and R. nathaliae during their desiccation and recovery process Methods Proton nuclear magnetic resonance (1H-NMR) and gas chromatography–mass spectrometry (GC–MS)-based metabolomics approach coupled with multivariate data analysis was utilised to identify the metabolomes of the plants from 90 biological replicates. Results Sucrose and the polyphenolic glycoside myconoside were predominant in almost equal amounts in all samples studied, regardless of their water content at sampling. During the dehydration process, a decrease in the relative content of fructose, galactose, and galactinol was observed while the contents of those metabolites were preserved in the partially rehydrated plants. Raffinose and myo-inositol were accumulated in dry samples. Conclusion Using 1H-NMR and GC–MS as two complementary analytical platforms provided a more complete picture of the metabolite composition for investigation of the desiccation and recovery process in resurrection plants.
PB  - Wiley
T2  - Phytochemical Analysis
T2  - Phytochemical Analysis
T1  - Metabolomics study of the desiccation and recovery process in the resurrection plants Ramonda serbica and R. nathaliae
VL  - n/a
IS  - n/a
DO  - 10.1002/pca.3151
ER  - 
@article{
author = "Gođevac, Dejan and Ivanović, Stefan and Simić, Katarina and Anđelković, Boban D. and Jovanović, Živko S. and Rakić, Tamara",
abstract = "Introduction Ramonda serbica and R. nathaliae are resurrection plants that have the remarkable ability to survive the complete desiccation of their vegetative organs (i.e. leaves, stem, roots) during periods of drought and rapidly revive when rewatered and rehydrated. Objective To investigate metabolic changes in R. serbica and R. nathaliae during their desiccation and recovery process Methods Proton nuclear magnetic resonance (1H-NMR) and gas chromatography–mass spectrometry (GC–MS)-based metabolomics approach coupled with multivariate data analysis was utilised to identify the metabolomes of the plants from 90 biological replicates. Results Sucrose and the polyphenolic glycoside myconoside were predominant in almost equal amounts in all samples studied, regardless of their water content at sampling. During the dehydration process, a decrease in the relative content of fructose, galactose, and galactinol was observed while the contents of those metabolites were preserved in the partially rehydrated plants. Raffinose and myo-inositol were accumulated in dry samples. Conclusion Using 1H-NMR and GC–MS as two complementary analytical platforms provided a more complete picture of the metabolite composition for investigation of the desiccation and recovery process in resurrection plants.",
publisher = "Wiley",
journal = "Phytochemical Analysis, Phytochemical Analysis",
title = "Metabolomics study of the desiccation and recovery process in the resurrection plants Ramonda serbica and R. nathaliae",
volume = "n/a",
number = "n/a",
doi = "10.1002/pca.3151"
}
Gođevac, D., Ivanović, S., Simić, K., Anđelković, B. D., Jovanović, Ž. S.,& Rakić, T..Metabolomics study of the desiccation and recovery process in the resurrection plants Ramonda serbica and R. nathaliae. in Phytochemical Analysis
Wiley., n/a(n/a).
https://doi.org/10.1002/pca.3151
Gođevac D, Ivanović S, Simić K, Anđelković BD, Jovanović ŽS, Rakić T. Metabolomics study of the desiccation and recovery process in the resurrection plants Ramonda serbica and R. nathaliae. in Phytochemical Analysis.n/a(n/a).
doi:10.1002/pca.3151 .
Gođevac, Dejan, Ivanović, Stefan, Simić, Katarina, Anđelković, Boban D., Jovanović, Živko S., Rakić, Tamara, "Metabolomics study of the desiccation and recovery process in the resurrection plants Ramonda serbica and R. nathaliae" in Phytochemical Analysis, n/a, no. n/a,
https://doi.org/10.1002/pca.3151 . .
1

An Integrated Approach in the Assessment of the Vlasina River System Pollution by Toxic Elements

Sakan, Sanja; Mihajlidi-Zelić, Aleksandra; Škrivanj, Sandra; Frančišković-Bilinski, Stanislav; Đorđević, Dragana

(2022)

TY  - JOUR
AU  - Sakan, Sanja
AU  - Mihajlidi-Zelić, Aleksandra
AU  - Škrivanj, Sandra
AU  - Frančišković-Bilinski, Stanislav
AU  - Đorđević, Dragana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5501
AB  - Increasing pollutant levels in surface water are a very important problem in developing countries. In Serbia, the largest rivers are transboundary rivers that cross the border already polluted. Taking this into account, evaluation of the distribution characteristics, ecological risk, and sources of toxic elements in river water and surface sediments in the watercourses of the Vlasina watershed is of great significance for the protection of water resources in Serbia. A total of 17 sediment and 18 water samples were collected and analyzed by Inductively Coupled Plasma—Optical Emission spectrometry (ICP-OES) and Inductively Coupled Plasma—Mass spectrometry (ICP-MS) to determine micro- and macroelements contents. The geo-accumulation index (Igeo) was applied to determine and classify the magnitude of toxic element pollution in this river sediment. The contents of the studied toxic elements were below water and sediment quality guidelines. For studied river water, results of principal component analysis (PCA) indicated the difference in behavior of Cr, Mn, Ni, Cu, and As and V, respectively. Cluster analysis (CA) classified water samples according to As and Cu content. The PCA results revealed that lead in river sediments had different behavior than other elements and can be associated mainly with anthropogenic sources. According to the degree of Igeo, the majority of sediments in the Vlasina region were uncontaminated regarding studied toxic elements. The origin of elements is mostly from natural processes such as soil and rock weathering.
T2  - Frontiers in Environmental Science
T1  - An Integrated Approach in the Assessment of the Vlasina River System Pollution by Toxic Elements
VL  - 10
ER  - 
@article{
author = "Sakan, Sanja and Mihajlidi-Zelić, Aleksandra and Škrivanj, Sandra and Frančišković-Bilinski, Stanislav and Đorđević, Dragana",
year = "2022",
abstract = "Increasing pollutant levels in surface water are a very important problem in developing countries. In Serbia, the largest rivers are transboundary rivers that cross the border already polluted. Taking this into account, evaluation of the distribution characteristics, ecological risk, and sources of toxic elements in river water and surface sediments in the watercourses of the Vlasina watershed is of great significance for the protection of water resources in Serbia. A total of 17 sediment and 18 water samples were collected and analyzed by Inductively Coupled Plasma—Optical Emission spectrometry (ICP-OES) and Inductively Coupled Plasma—Mass spectrometry (ICP-MS) to determine micro- and macroelements contents. The geo-accumulation index (Igeo) was applied to determine and classify the magnitude of toxic element pollution in this river sediment. The contents of the studied toxic elements were below water and sediment quality guidelines. For studied river water, results of principal component analysis (PCA) indicated the difference in behavior of Cr, Mn, Ni, Cu, and As and V, respectively. Cluster analysis (CA) classified water samples according to As and Cu content. The PCA results revealed that lead in river sediments had different behavior than other elements and can be associated mainly with anthropogenic sources. According to the degree of Igeo, the majority of sediments in the Vlasina region were uncontaminated regarding studied toxic elements. The origin of elements is mostly from natural processes such as soil and rock weathering.",
journal = "Frontiers in Environmental Science",
title = "An Integrated Approach in the Assessment of the Vlasina River System Pollution by Toxic Elements",
volume = "10"
}
Sakan, S., Mihajlidi-Zelić, A., Škrivanj, S., Frančišković-Bilinski, S.,& Đorđević, D.. (2022). An Integrated Approach in the Assessment of the Vlasina River System Pollution by Toxic Elements. in Frontiers in Environmental Science, 10.
Sakan S, Mihajlidi-Zelić A, Škrivanj S, Frančišković-Bilinski S, Đorđević D. An Integrated Approach in the Assessment of the Vlasina River System Pollution by Toxic Elements. in Frontiers in Environmental Science. 2022;10..
Sakan, Sanja, Mihajlidi-Zelić, Aleksandra, Škrivanj, Sandra, Frančišković-Bilinski, Stanislav, Đorđević, Dragana, "An Integrated Approach in the Assessment of the Vlasina River System Pollution by Toxic Elements" in Frontiers in Environmental Science, 10 (2022).

Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2

Perić, Ivana; Lješević, Marija; Beškoski, Vladimir P.; Nikolić, Milan; Filipović, Dragana

(2022)

TY  - DATA
AU  - Perić, Ivana
AU  - Lješević, Marija
AU  - Beškoski, Vladimir P.
AU  - Nikolić, Milan
AU  - Filipović, Dragana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5499
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5500
AB  - Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.
T2  - Psychopharmacology
T1  - Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2
ER  - 
@misc{
author = "Perić, Ivana and Lješević, Marija and Beškoski, Vladimir P. and Nikolić, Milan and Filipović, Dragana",
year = "2022",
abstract = "Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.",
journal = "Psychopharmacology",
title = "Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2"
}
Perić, I., Lješević, M., Beškoski, V. P., Nikolić, M.,& Filipović, D.. (2022). Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2. in Psychopharmacology.
Perić I, Lješević M, Beškoski VP, Nikolić M, Filipović D. Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2. in Psychopharmacology. 2022;..
Perić, Ivana, Lješević, Marija, Beškoski, Vladimir P., Nikolić, Milan, Filipović, Dragana, "Supplementary information for the article: Perić, I.; Lješević, M.; Beškoski, V.; Nikolić, M.; Filipović, D. Metabolomic Profiling Relates Tianeptine Effectiveness with Hippocampal GABA, Myo-Inositol, Cholesterol, and Fatty Acid Metabolism Restoration in Socially Isolated Rats. Psychopharmacology 2022, 2" in Psychopharmacology (2022).

Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats

Perić, Ivana; Lješević, Marija; Beškoski, Vladimir P.; Nikolić, Milan; Filipović, Dragana

(2022)

TY  - JOUR
AU  - Perić, Ivana
AU  - Lješević, Marija
AU  - Beškoski, Vladimir P.
AU  - Nikolić, Milan
AU  - Filipović, Dragana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5499
AB  - Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.
T2  - Psychopharmacology
T1  - Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats
DO  - 10.1007/s00213-022-06180-y
ER  - 
@article{
author = "Perić, Ivana and Lješević, Marija and Beškoski, Vladimir P. and Nikolić, Milan and Filipović, Dragana",
year = "2022",
abstract = "Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.",
journal = "Psychopharmacology",
title = "Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats",
doi = "10.1007/s00213-022-06180-y"
}
Perić, I., Lješević, M., Beškoski, V. P., Nikolić, M.,& Filipović, D.. (2022). Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. in Psychopharmacology.
https://doi.org/10.1007/s00213-022-06180-y
Perić I, Lješević M, Beškoski VP, Nikolić M, Filipović D. Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. in Psychopharmacology. 2022;.
doi:10.1007/s00213-022-06180-y .
Perić, Ivana, Lješević, Marija, Beškoski, Vladimir P., Nikolić, Milan, Filipović, Dragana, "Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats" in Psychopharmacology (2022),
https://doi.org/10.1007/s00213-022-06180-y . .
1

Gamma-ray-induced structural transformation of GQDs towards the improvement of their optical properties, monitoring of selected toxic compounds, and photo-induced effect on bacterial strains

Dorontic, Sladjana; Bonasera, Aurelio; Scopelliti, Michelangelo; Marković, Olivera; Bajuk Bogdanović, Danica; Ciasca, Gabriele; Romanò, Sabrina; Dimkić, Ivica; Budimir, Milica; Marinković, Dragana; Jovanovic, Svetlana

(MDPI, 2022)

TY  - JOUR
AU  - Dorontic, Sladjana
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Marković, Olivera
AU  - Bajuk Bogdanović, Danica
AU  - Ciasca, Gabriele
AU  - Romanò, Sabrina
AU  - Dimkić, Ivica
AU  - Budimir, Milica
AU  - Marinković, Dragana
AU  - Jovanovic, Svetlana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5468
AB  - Structural modification of different carbon-based nanomaterials is often necessary to
improve their morphology and optical properties, particularly the incorporation of N-atoms in
graphene quantum dots (GQDs). Here, a clean, simple, one-step, and eco-friendly method for
N-doping of GQDs using gamma irradiation is reported. GQDs were irradiated in the presence
of the different ethylenediamine (EDA) amounts (1 g, 5 g, and 10 g) and the highest % of N was
detected in the presence of 10 g. N-doped GQDs emitted strong, blue photoluminescence (PL).
Photoluminescence quantum yield was increased from 1.45, as obtained for non-irradiated dots,
to 7.24% for those irradiated in the presence of 1 g of EDA. Modified GQDs were investigated as
a PL probe for the detection of insecticide Carbofuran (2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-
yl methylcarbamate) and herbicide Amitrole (3-amino-1,2,4-triazole). The limit of detection was
5.4 µmol L−1
for Carbofuran. For the first time, Amitrole was detected by GQDs in a turn-off/turn-on
mechanism using Pd(II) ions as a quenching agent. First, Pd(II) ions were quenched (turn-off) PL
of GQDs, while after Amitrole addition, PL was recovered linearly with Amitrole concentration
(turn-on). LOD was 2.03 µmol L−1
. These results suggest that modified GQDs can be used as an
efficient new material for Carbofuran and Amitrole detection. Furthermore, the phototoxicity of dots
was investigated on both Gram-positive and Gram-negative bacterial strains. When bacterial cells
were exposed to different GQD concentrations and illuminated with light of 470 nm wavelength, the
toxic effects were not observed.
PB  - MDPI
T2  - Nanomaterials
T1  - Gamma-ray-induced structural transformation of GQDs towards the improvement of their optical properties, monitoring of selected toxic compounds, and photo-induced effect on bacterial strains
VL  - 12
SP  - 2714
DO  - 10.3390/nano12152714
ER  - 
@article{
author = "Dorontic, Sladjana and Bonasera, Aurelio and Scopelliti, Michelangelo and Marković, Olivera and Bajuk Bogdanović, Danica and Ciasca, Gabriele and Romanò, Sabrina and Dimkić, Ivica and Budimir, Milica and Marinković, Dragana and Jovanovic, Svetlana",
year = "2022",
abstract = "Structural modification of different carbon-based nanomaterials is often necessary to
improve their morphology and optical properties, particularly the incorporation of N-atoms in
graphene quantum dots (GQDs). Here, a clean, simple, one-step, and eco-friendly method for
N-doping of GQDs using gamma irradiation is reported. GQDs were irradiated in the presence
of the different ethylenediamine (EDA) amounts (1 g, 5 g, and 10 g) and the highest % of N was
detected in the presence of 10 g. N-doped GQDs emitted strong, blue photoluminescence (PL).
Photoluminescence quantum yield was increased from 1.45, as obtained for non-irradiated dots,
to 7.24% for those irradiated in the presence of 1 g of EDA. Modified GQDs were investigated as
a PL probe for the detection of insecticide Carbofuran (2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-
yl methylcarbamate) and herbicide Amitrole (3-amino-1,2,4-triazole). The limit of detection was
5.4 µmol L−1
for Carbofuran. For the first time, Amitrole was detected by GQDs in a turn-off/turn-on
mechanism using Pd(II) ions as a quenching agent. First, Pd(II) ions were quenched (turn-off) PL
of GQDs, while after Amitrole addition, PL was recovered linearly with Amitrole concentration
(turn-on). LOD was 2.03 µmol L−1
. These results suggest that modified GQDs can be used as an
efficient new material for Carbofuran and Amitrole detection. Furthermore, the phototoxicity of dots
was investigated on both Gram-positive and Gram-negative bacterial strains. When bacterial cells
were exposed to different GQD concentrations and illuminated with light of 470 nm wavelength, the
toxic effects were not observed.",
publisher = "MDPI",
journal = "Nanomaterials",
title = "Gamma-ray-induced structural transformation of GQDs towards the improvement of their optical properties, monitoring of selected toxic compounds, and photo-induced effect on bacterial strains",
volume = "12",
pages = "2714",
doi = "10.3390/nano12152714"
}
Dorontic, S., Bonasera, A., Scopelliti, M., Marković, O., Bajuk Bogdanović, D., Ciasca, G., Romanò, S., Dimkić, I., Budimir, M., Marinković, D.,& Jovanovic, S.. (2022). Gamma-ray-induced structural transformation of GQDs towards the improvement of their optical properties, monitoring of selected toxic compounds, and photo-induced effect on bacterial strains. in Nanomaterials
MDPI., 12, 2714.
https://doi.org/10.3390/nano12152714
Dorontic S, Bonasera A, Scopelliti M, Marković O, Bajuk Bogdanović D, Ciasca G, Romanò S, Dimkić I, Budimir M, Marinković D, Jovanovic S. Gamma-ray-induced structural transformation of GQDs towards the improvement of their optical properties, monitoring of selected toxic compounds, and photo-induced effect on bacterial strains. in Nanomaterials. 2022;12:2714.
doi:10.3390/nano12152714 .
Dorontic, Sladjana, Bonasera, Aurelio, Scopelliti, Michelangelo, Marković, Olivera, Bajuk Bogdanović, Danica, Ciasca, Gabriele, Romanò, Sabrina, Dimkić, Ivica, Budimir, Milica, Marinković, Dragana, Jovanovic, Svetlana, "Gamma-ray-induced structural transformation of GQDs towards the improvement of their optical properties, monitoring of selected toxic compounds, and photo-induced effect on bacterial strains" in Nanomaterials, 12 (2022):2714,
https://doi.org/10.3390/nano12152714 . .
1

4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease

Komatović, Katarina; Matošević, Ana; Terzić-Jovanović, Nataša; Žunec, Suzana; Šegan, Sandra; Zlatović, Mario; Maraković, Nikola; Bosak, Anita; Opsenica, Dejan

(MDPI, 2022)

TY  - JOUR
AU  - Komatović, Katarina
AU  - Matošević, Ana
AU  - Terzić-Jovanović, Nataša
AU  - Žunec, Suzana
AU  - Šegan, Sandra
AU  - Zlatović, Mario
AU  - Maraković, Nikola
AU  - Bosak, Anita
AU  - Opsenica, Dejan
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5381
AB  - Considering that acetylcholinesterase (AChE) inhibition is the most important mode of action expected of a potential drug used for the treatment of symptoms of Alzheimer’s disease (AD), our previous pilot study of 4-aminoquinolines as potential human cholinesterase inhibitors was extended to twenty-two new structurally distinct 4-aminoquinolines bearing an adamantane moiety. Inhibition studies revealed that all of the compounds were very potent inhibitors of AChE and butyrylcholinesterase (BChE), with inhibition constants (Ki) ranging between 0.075 and 25 µM. The tested compounds exhibited a modest selectivity between the two cholinesterases; the most selective for BChE was compound 14, which displayed a 10 times higher preference, while compound 19 was a 5.8 times more potent inhibitor of AChE. Most of the compounds were estimated to be able to cross the blood–brain barrier (BBB) by passive transport. Evaluation of druglikeness singled out fourteen compounds with possible oral route of administration. The tested compounds displayed modest but generally higher antioxidant activity than the structurally similar AD drug tacrine. Compound 19 showed the highest reducing power, comparable to those of standard antioxidants. Considering their simple structure, high inhibition of AChE and BChE, and ability to cross the BBB, 4-aminoquinoline-based adamantanes show promise as structural scaffolds for further design of novel central nervous system drugs. Among them, two compounds stand out: compound 5 as the most potent inhibitor of both cholinesterases with a Ki constant in low nano molar range and the potential to cross the BBB, and compound 8, which met all our requirements, including high cholinesterase inhibition, good oral bioavailability, and antioxidative effect. The QSAR model revealed that AChE and BChE inhibition was mainly influenced by the ring and topological descriptors MCD, Nnum, RP, and RSIpw3, which defined the shape, conformational flexibility, and surface properties of the molecules
PB  - MDPI
T2  - Pharmaceutics
T1  - 4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease
VL  - 14
IS  - 6
SP  - 1305
DO  - 10.3390/pharmaceutics14061305
ER  - 
@article{
author = "Komatović, Katarina and Matošević, Ana and Terzić-Jovanović, Nataša and Žunec, Suzana and Šegan, Sandra and Zlatović, Mario and Maraković, Nikola and Bosak, Anita and Opsenica, Dejan",
year = "2022",
abstract = "Considering that acetylcholinesterase (AChE) inhibition is the most important mode of action expected of a potential drug used for the treatment of symptoms of Alzheimer’s disease (AD), our previous pilot study of 4-aminoquinolines as potential human cholinesterase inhibitors was extended to twenty-two new structurally distinct 4-aminoquinolines bearing an adamantane moiety. Inhibition studies revealed that all of the compounds were very potent inhibitors of AChE and butyrylcholinesterase (BChE), with inhibition constants (Ki) ranging between 0.075 and 25 µM. The tested compounds exhibited a modest selectivity between the two cholinesterases; the most selective for BChE was compound 14, which displayed a 10 times higher preference, while compound 19 was a 5.8 times more potent inhibitor of AChE. Most of the compounds were estimated to be able to cross the blood–brain barrier (BBB) by passive transport. Evaluation of druglikeness singled out fourteen compounds with possible oral route of administration. The tested compounds displayed modest but generally higher antioxidant activity than the structurally similar AD drug tacrine. Compound 19 showed the highest reducing power, comparable to those of standard antioxidants. Considering their simple structure, high inhibition of AChE and BChE, and ability to cross the BBB, 4-aminoquinoline-based adamantanes show promise as structural scaffolds for further design of novel central nervous system drugs. Among them, two compounds stand out: compound 5 as the most potent inhibitor of both cholinesterases with a Ki constant in low nano molar range and the potential to cross the BBB, and compound 8, which met all our requirements, including high cholinesterase inhibition, good oral bioavailability, and antioxidative effect. The QSAR model revealed that AChE and BChE inhibition was mainly influenced by the ring and topological descriptors MCD, Nnum, RP, and RSIpw3, which defined the shape, conformational flexibility, and surface properties of the molecules",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease",
volume = "14",
number = "6",
pages = "1305",
doi = "10.3390/pharmaceutics14061305"
}
Komatović, K., Matošević, A., Terzić-Jovanović, N., Žunec, S., Šegan, S., Zlatović, M., Maraković, N., Bosak, A.,& Opsenica, D.. (2022). 4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease. in Pharmaceutics
MDPI., 14(6), 1305.
https://doi.org/10.3390/pharmaceutics14061305
Komatović K, Matošević A, Terzić-Jovanović N, Žunec S, Šegan S, Zlatović M, Maraković N, Bosak A, Opsenica D. 4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease. in Pharmaceutics. 2022;14(6):1305.
doi:10.3390/pharmaceutics14061305 .
Komatović, Katarina, Matošević, Ana, Terzić-Jovanović, Nataša, Žunec, Suzana, Šegan, Sandra, Zlatović, Mario, Maraković, Nikola, Bosak, Anita, Opsenica, Dejan, "4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer’s Disease" in Pharmaceutics, 14, no. 6 (2022):1305,
https://doi.org/10.3390/pharmaceutics14061305 . .
7

Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants

Kop, Tatjana; Bjelaković, Mira S.; Živković, Ljiljana S.; Žekić, Andrijana; Milić, Dragana

(Elsevier, 2022)

TY  - JOUR
AU  - Kop, Tatjana
AU  - Bjelaković, Mira S.
AU  - Živković, Ljiljana S.
AU  - Žekić, Andrijana
AU  - Milić, Dragana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5319
AB  - Despite many advantages, the practical application of fullerene C60 and curcumin (CUR) has been limited by their hydrophobic nature, deficient solubility in aqueous media and, therefore, poor bioavailability. In this study, aqueous nanoformulations containing C60 and CUR in the absence and presence of three solubility enhancers, β-cyclodextrin (CD), Tween 80 (T80) and polyvinylpyrrolidone (PVP), were prepared and subjected to the antioxidant activity assessment. The content of C60 and CUR, stability, size and morphology of nanoparticles were determined using UV–vis, DLS and SEM techniques. Contrary to better solubility of pure C60 than the corresponding C60-CUR system, the solubilization of CUR in hybrid suspensions was improved compared to corresponding pure CUR suspensions, with the exception of the C60-CUR-PVP formulation. The DLS results revealed nearly monodisperse nature of CUR-T80 nanoformulation, while other ones ranged from widely dispersed to polydispersed. Depending on the type of solubilizer, similarity was observed in the particle size distributions of T80- and PVP-coated nanoformulations as well as water and CD nanoformulations. The presence of T80 differently and significantly reduces the particle size in all three nanoformulations, while PVP slightly reduces CUR-based nanoparticles but increases the size of C60 nanoparticles. Zeta potential values, ranging from − 9 mV to − 34 mV, show variation in the starting stability of nanoparticles, from unstable or relatively stable three PVP formulations and C60-T80 to highly stable CUR-T80 and C60-water. Compared to water nanoformulations as a control, SEM images of dispersant-coated nanoparticles lost the visible morphology of active components, showing variation in their morphology depending on the type of dispersant and active component used. Nanoformulations containing CUR in PVP and T80 expressed a very good antioxidant potential in DPPH radical scavenging assay, much stronger than ascorbic acid. At the same time, a moderate to high antioxidant activity in β-carotene bleaching assay was reached in PVP and T80 nanoformulations containing C60, CUR, and their noncovalent hybrid, as well. Our studies have shown that T80 and PVP colloidal systems containing C60-CUR hybrid, but also their individual components, can be used as stable antioxidant nanoformulations with potential application in the field of food and pharmacology.
PB  - Elsevier
T2  - Colloids and Surfaces A: Physicochemical and Engineering Aspects
T1  - Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants
VL  - 648
DO  - 10.1016/j.colsurfa.2022.129379
ER  - 
@article{
author = "Kop, Tatjana and Bjelaković, Mira S. and Živković, Ljiljana S. and Žekić, Andrijana and Milić, Dragana",
year = "2022",
abstract = "Despite many advantages, the practical application of fullerene C60 and curcumin (CUR) has been limited by their hydrophobic nature, deficient solubility in aqueous media and, therefore, poor bioavailability. In this study, aqueous nanoformulations containing C60 and CUR in the absence and presence of three solubility enhancers, β-cyclodextrin (CD), Tween 80 (T80) and polyvinylpyrrolidone (PVP), were prepared and subjected to the antioxidant activity assessment. The content of C60 and CUR, stability, size and morphology of nanoparticles were determined using UV–vis, DLS and SEM techniques. Contrary to better solubility of pure C60 than the corresponding C60-CUR system, the solubilization of CUR in hybrid suspensions was improved compared to corresponding pure CUR suspensions, with the exception of the C60-CUR-PVP formulation. The DLS results revealed nearly monodisperse nature of CUR-T80 nanoformulation, while other ones ranged from widely dispersed to polydispersed. Depending on the type of solubilizer, similarity was observed in the particle size distributions of T80- and PVP-coated nanoformulations as well as water and CD nanoformulations. The presence of T80 differently and significantly reduces the particle size in all three nanoformulations, while PVP slightly reduces CUR-based nanoparticles but increases the size of C60 nanoparticles. Zeta potential values, ranging from − 9 mV to − 34 mV, show variation in the starting stability of nanoparticles, from unstable or relatively stable three PVP formulations and C60-T80 to highly stable CUR-T80 and C60-water. Compared to water nanoformulations as a control, SEM images of dispersant-coated nanoparticles lost the visible morphology of active components, showing variation in their morphology depending on the type of dispersant and active component used. Nanoformulations containing CUR in PVP and T80 expressed a very good antioxidant potential in DPPH radical scavenging assay, much stronger than ascorbic acid. At the same time, a moderate to high antioxidant activity in β-carotene bleaching assay was reached in PVP and T80 nanoformulations containing C60, CUR, and their noncovalent hybrid, as well. Our studies have shown that T80 and PVP colloidal systems containing C60-CUR hybrid, but also their individual components, can be used as stable antioxidant nanoformulations with potential application in the field of food and pharmacology.",
publisher = "Elsevier",
journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",
title = "Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants",
volume = "648",
doi = "10.1016/j.colsurfa.2022.129379"
}
Kop, T., Bjelaković, M. S., Živković, L. S., Žekić, A.,& Milić, D.. (2022). Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants. in Colloids and Surfaces A: Physicochemical and Engineering Aspects
Elsevier., 648.
https://doi.org/10.1016/j.colsurfa.2022.129379
Kop T, Bjelaković MS, Živković LS, Žekić A, Milić D. Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants. in Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2022;648.
doi:10.1016/j.colsurfa.2022.129379 .
Kop, Tatjana, Bjelaković, Mira S., Živković, Ljiljana S., Žekić, Andrijana, Milić, Dragana, "Stable colloidal dispersions of fullerene C60, curcumin and C60-curcumin in water as potential antioxidants" in Colloids and Surfaces A: Physicochemical and Engineering Aspects, 648 (2022),
https://doi.org/10.1016/j.colsurfa.2022.129379 . .

Unraveling the anti-virulence potential and antifungal efficacy of 5-aminotetrazoles using the zebrafish model of disseminated candidiasis

Radaković, Nataša; Nikolić, Andrea; Terzić-Jovanović, Nataša; Stojković, Pavle; Stanković, Nada; Šolaja, Bogdan A.; Opsenica, Igor; Pavić, Aleksandar

(Elsevier, 2022)

TY  - JOUR
AU  - Radaković, Nataša
AU  - Nikolić, Andrea
AU  - Terzić-Jovanović, Nataša
AU  - Stojković, Pavle
AU  - Stanković, Nada
AU  - Šolaja, Bogdan A.
AU  - Opsenica, Igor
AU  - Pavić, Aleksandar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4877
AB  - Candida albicans remains the main causal agent of candidiasis, the most common fungal infection with disturbingly high mortality rates worldwide. The limited diversity and efficacy of clinical antifungal drugs, exacerbated by emerging drug resistance, have resulted in the failure of current antifungal therapies. This imposes an urgent demand for the development of innovative strategies for effective eradication of candidal infections. While the existing clinical drugs display fungicidal or fungistatic activity, the strategy specifically targeting C. albicans filamentation, as the most important virulence trait, represents an attractive approach for overcoming the drawbacks related to clinical antifungals. The results acquired in this study revealed the significant potential of 5-aminotetrazoles as a new class of effective and safe anti-virulence agents. Moreover, these novel agents were active when applied both alone and in combination with clinically approved polyenes. Complete prevention of C. albicans morphogenetic yeast-to-hyphae transition was achieved at doses as low as 1.3 μM under conditions mimicking various filamentation-responsive stimuli in the human body, while no cardio- or hepatotoxicity was observed at doses as high as 200 μM. The treatment of C. albicans-infected zebrafish embryos with nystatin alone had low efficacy, while the combination of nystatin and selected 5-aminotetrazoles prevented fungal filamentation, successfully eliminating the infection and rescuing the infected embryos from lethal disseminated candidiasis. In addition, the most potent anti-virulence 5-aminotetrazole prevented C. albicans in developing the resistance to nystatin when applied in combination, keeping the fungus sensitive to the antifungal drug.
PB  - Elsevier
T2  - European Journal of Medicinal Chemistry
T1  - Unraveling the anti-virulence potential and antifungal efficacy of 5-aminotetrazoles using the zebrafish model of disseminated candidiasis
VL  - 230
SP  - 114137
DO  - 10.1016/j.ejmech.2022.114137
ER  - 
@article{
author = "Radaković, Nataša and Nikolić, Andrea and Terzić-Jovanović, Nataša and Stojković, Pavle and Stanković, Nada and Šolaja, Bogdan A. and Opsenica, Igor and Pavić, Aleksandar",
year = "2022",
abstract = "Candida albicans remains the main causal agent of candidiasis, the most common fungal infection with disturbingly high mortality rates worldwide. The limited diversity and efficacy of clinical antifungal drugs, exacerbated by emerging drug resistance, have resulted in the failure of current antifungal therapies. This imposes an urgent demand for the development of innovative strategies for effective eradication of candidal infections. While the existing clinical drugs display fungicidal or fungistatic activity, the strategy specifically targeting C. albicans filamentation, as the most important virulence trait, represents an attractive approach for overcoming the drawbacks related to clinical antifungals. The results acquired in this study revealed the significant potential of 5-aminotetrazoles as a new class of effective and safe anti-virulence agents. Moreover, these novel agents were active when applied both alone and in combination with clinically approved polyenes. Complete prevention of C. albicans morphogenetic yeast-to-hyphae transition was achieved at doses as low as 1.3 μM under conditions mimicking various filamentation-responsive stimuli in the human body, while no cardio- or hepatotoxicity was observed at doses as high as 200 μM. The treatment of C. albicans-infected zebrafish embryos with nystatin alone had low efficacy, while the combination of nystatin and selected 5-aminotetrazoles prevented fungal filamentation, successfully eliminating the infection and rescuing the infected embryos from lethal disseminated candidiasis. In addition, the most potent anti-virulence 5-aminotetrazole prevented C. albicans in developing the resistance to nystatin when applied in combination, keeping the fungus sensitive to the antifungal drug.",
publisher = "Elsevier",
journal = "European Journal of Medicinal Chemistry",
title = "Unraveling the anti-virulence potential and antifungal efficacy of 5-aminotetrazoles using the zebrafish model of disseminated candidiasis",
volume = "230",
pages = "114137",
doi = "10.1016/j.ejmech.2022.114137"
}
Radaković, N., Nikolić, A., Terzić-Jovanović, N., Stojković, P., Stanković, N., Šolaja, B. A., Opsenica, I.,& Pavić, A.. (2022). Unraveling the anti-virulence potential and antifungal efficacy of 5-aminotetrazoles using the zebrafish model of disseminated candidiasis. in European Journal of Medicinal Chemistry
Elsevier., 230, 114137.
https://doi.org/10.1016/j.ejmech.2022.114137
Radaković N, Nikolić A, Terzić-Jovanović N, Stojković P, Stanković N, Šolaja BA, Opsenica I, Pavić A. Unraveling the anti-virulence potential and antifungal efficacy of 5-aminotetrazoles using the zebrafish model of disseminated candidiasis. in European Journal of Medicinal Chemistry. 2022;230:114137.
doi:10.1016/j.ejmech.2022.114137 .
Radaković, Nataša, Nikolić, Andrea, Terzić-Jovanović, Nataša, Stojković, Pavle, Stanković, Nada, Šolaja, Bogdan A., Opsenica, Igor, Pavić, Aleksandar, "Unraveling the anti-virulence potential and antifungal efficacy of 5-aminotetrazoles using the zebrafish model of disseminated candidiasis" in European Journal of Medicinal Chemistry, 230 (2022):114137,
https://doi.org/10.1016/j.ejmech.2022.114137 . .
2

Reconstruction of palaeoenvironment and ancient human activities at Obrovac-type settlements (Serbia) using a geochemical approach

Veselinović, Gorica; Tripković, Boban; Antić, Nevena; Šajnović, Aleksandra; Kašanin-Grubin, Milica; Tosti, Tomislav; Penezić, Kristina

(Elsevier, 2022)

TY  - JOUR
AU  - Veselinović, Gorica
AU  - Tripković, Boban
AU  - Antić, Nevena
AU  - Šajnović, Aleksandra
AU  - Kašanin-Grubin, Milica
AU  - Tosti, Tomislav
AU  - Penezić, Kristina
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5321
AB  - This study aims to determine the palaeoenvironmental characteristics and activity patterns of Obrovac-type archaeological sites in Western Serbia, dated to the Late Neolithic/Early Eneolithic period, ∼5th millennium BC. These mound-like sites, enclosed by a wide ditch, that are not known in other parts of the central Balkan area, have long intrigued archaeologists investigating their origin and function over the last few decades.In this study, for the first time, organic-geochemical analysis of paleosol samples from the Obrovac-type sites was applied with the aim of palaeoenvironmental reconstruction. Additionally, organic carbon content and anion analysis of 58 subsoil samples from these settlements were performed to determine the use of space and activity zones.The analysis of biomarkers from selected sites suggests significant plant biodiversity in the Mačva region during the Late Neolithic/Early Eneolithic. Distribution of n-alkanes with the maximum at n-C25 and predominance of C30 hop-22(29)-ene among hopanoids in samples from Obrovac type-sites indisputably indicates that macrophytes are a dominant source of organic matter, implying a marshy and floodplain depositional environment. On the other side, a strong signal of long-chain n-alkanes indicates the input of terrestrial plants into the precursor biomass, confirming that this environment was habitable for the first settlers in this region. Anion-based analysis delineates certain activity zones, demonstrating that Obrovac type-sites manifest rather complex spatial behavior despite their relatively small size and available space.
PB  - Elsevier
T2  - Quaternary International
T2  - Quaternary International
T1  - Reconstruction of palaeoenvironment and ancient human activities at Obrovac-type settlements (Serbia) using a geochemical approach
VL  - 610
SP  - 122
EP  - 132
DO  - 10.1016/j.quaint.2021.09.001
ER  - 
@article{
author = "Veselinović, Gorica and Tripković, Boban and Antić, Nevena and Šajnović, Aleksandra and Kašanin-Grubin, Milica and Tosti, Tomislav and Penezić, Kristina",
year = "2022",
abstract = "This study aims to determine the palaeoenvironmental characteristics and activity patterns of Obrovac-type archaeological sites in Western Serbia, dated to the Late Neolithic/Early Eneolithic period, ∼5th millennium BC. These mound-like sites, enclosed by a wide ditch, that are not known in other parts of the central Balkan area, have long intrigued archaeologists investigating their origin and function over the last few decades.In this study, for the first time, organic-geochemical analysis of paleosol samples from the Obrovac-type sites was applied with the aim of palaeoenvironmental reconstruction. Additionally, organic carbon content and anion analysis of 58 subsoil samples from these settlements were performed to determine the use of space and activity zones.The analysis of biomarkers from selected sites suggests significant plant biodiversity in the Mačva region during the Late Neolithic/Early Eneolithic. Distribution of n-alkanes with the maximum at n-C25 and predominance of C30 hop-22(29)-ene among hopanoids in samples from Obrovac type-sites indisputably indicates that macrophytes are a dominant source of organic matter, implying a marshy and floodplain depositional environment. On the other side, a strong signal of long-chain n-alkanes indicates the input of terrestrial plants into the precursor biomass, confirming that this environment was habitable for the first settlers in this region. Anion-based analysis delineates certain activity zones, demonstrating that Obrovac type-sites manifest rather complex spatial behavior despite their relatively small size and available space.",
publisher = "Elsevier",
journal = "Quaternary International, Quaternary International",
title = "Reconstruction of palaeoenvironment and ancient human activities at Obrovac-type settlements (Serbia) using a geochemical approach",
volume = "610",
pages = "122-132",
doi = "10.1016/j.quaint.2021.09.001"
}
Veselinović, G., Tripković, B., Antić, N., Šajnović, A., Kašanin-Grubin, M., Tosti, T.,& Penezić, K.. (2022). Reconstruction of palaeoenvironment and ancient human activities at Obrovac-type settlements (Serbia) using a geochemical approach. in Quaternary International
Elsevier., 610, 122-132.
https://doi.org/10.1016/j.quaint.2021.09.001
Veselinović G, Tripković B, Antić N, Šajnović A, Kašanin-Grubin M, Tosti T, Penezić K. Reconstruction of palaeoenvironment and ancient human activities at Obrovac-type settlements (Serbia) using a geochemical approach. in Quaternary International. 2022;610:122-132.
doi:10.1016/j.quaint.2021.09.001 .
Veselinović, Gorica, Tripković, Boban, Antić, Nevena, Šajnović, Aleksandra, Kašanin-Grubin, Milica, Tosti, Tomislav, Penezić, Kristina, "Reconstruction of palaeoenvironment and ancient human activities at Obrovac-type settlements (Serbia) using a geochemical approach" in Quaternary International, 610 (2022):122-132,
https://doi.org/10.1016/j.quaint.2021.09.001 . .
1

Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity

Stevanović, Nevena; Zlatar, Matija; Novaković, Irena T.; Pevec, Andrej; Radanović, Dušanka D.; Matić, Ivana Z.; Đorđić Crnogorac, Marija; Stanojković, Tatjana; Vujčić, Miroslava; Gruden, Maja; Sladić, Dušan; Anđelković, Katarina K.; Turel, Iztok; Čobeljić, Božidar

(Royal Society of Chemistry (RSC), 2022)

TY  - JOUR
AU  - Stevanović, Nevena
AU  - Zlatar, Matija
AU  - Novaković, Irena T.
AU  - Pevec, Andrej
AU  - Radanović, Dušanka D.
AU  - Matić, Ivana Z.
AU  - Đorđić Crnogorac, Marija
AU  - Stanojković, Tatjana
AU  - Vujčić, Miroslava
AU  - Gruden, Maja
AU  - Sladić, Dušan
AU  - Anđelković, Katarina K.
AU  - Turel, Iztok
AU  - Čobeljić, Božidar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4857
AB  - In this paper, Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and DFT calculations. In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear penta-coordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], respectively, while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-negative and Gram-positive bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin.
PB  - Royal Society of Chemistry (RSC)
T2  - Dalton Transactions
T1  - Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity
VL  - 51
IS  - 1
SP  - 185
EP  - 196
DO  - 10.1039/D1DT03169D
ER  - 
@article{
author = "Stevanović, Nevena and Zlatar, Matija and Novaković, Irena T. and Pevec, Andrej and Radanović, Dušanka D. and Matić, Ivana Z. and Đorđić Crnogorac, Marija and Stanojković, Tatjana and Vujčić, Miroslava and Gruden, Maja and Sladić, Dušan and Anđelković, Katarina K. and Turel, Iztok and Čobeljić, Božidar",
year = "2022",
abstract = "In this paper, Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and DFT calculations. In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear penta-coordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], respectively, while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-negative and Gram-positive bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin.",
publisher = "Royal Society of Chemistry (RSC)",
journal = "Dalton Transactions",
title = "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity",
volume = "51",
number = "1",
pages = "185-196",
doi = "10.1039/D1DT03169D"
}
Stevanović, N., Zlatar, M., Novaković, I. T., Pevec, A., Radanović, D. D., Matić, I. Z., Đorđić Crnogorac, M., Stanojković, T., Vujčić, M., Gruden, M., Sladić, D., Anđelković, K. K., Turel, I.,& Čobeljić, B.. (2022). Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity. in Dalton Transactions
Royal Society of Chemistry (RSC)., 51(1), 185-196.
https://doi.org/10.1039/D1DT03169D
Stevanović N, Zlatar M, Novaković IT, Pevec A, Radanović DD, Matić IZ, Đorđić Crnogorac M, Stanojković T, Vujčić M, Gruden M, Sladić D, Anđelković KK, Turel I, Čobeljić B. Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity. in Dalton Transactions. 2022;51(1):185-196.
doi:10.1039/D1DT03169D .
Stevanović, Nevena, Zlatar, Matija, Novaković, Irena T., Pevec, Andrej, Radanović, Dušanka D., Matić, Ivana Z., Đorđić Crnogorac, Marija, Stanojković, Tatjana, Vujčić, Miroslava, Gruden, Maja, Sladić, Dušan, Anđelković, Katarina K., Turel, Iztok, Čobeljić, Božidar, "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity" in Dalton Transactions, 51, no. 1 (2022):185-196,
https://doi.org/10.1039/D1DT03169D . .
4
3
1
2

Supporting information for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"

Stevanović, Nevena; Zlatar, Matija; Novaković, Irena T.; Pevec, Andrej; Radanović, Dušanka D.; Matić, Ivana Z.; Đorđić Crnogorac, Marija; Stanojković, Tatjana; Vujčić, Miroslava; Gruden, Maja; Sladić, Dušan; Anđelković, Katarina K.; Turel, Iztok; Čobeljić, Božidar

(Royal Society of Chemistry (RSC), 2022)

TY  - DATA
AU  - Stevanović, Nevena
AU  - Zlatar, Matija
AU  - Novaković, Irena T.
AU  - Pevec, Andrej
AU  - Radanović, Dušanka D.
AU  - Matić, Ivana Z.
AU  - Đorđić Crnogorac, Marija
AU  - Stanojković, Tatjana
AU  - Vujčić, Miroslava
AU  - Gruden, Maja
AU  - Sladić, Dušan
AU  - Anđelković, Katarina K.
AU  - Turel, Iztok
AU  - Čobeljić, Božidar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4858
AB  - In this paper, Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and DFT calculations. In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear penta-coordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], respectively, while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-negative and Gram-positive bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin.
PB  - Royal Society of Chemistry (RSC)
T2  - Dalton Transactions
T1  - Supporting information for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4858
ER  - 
@misc{
author = "Stevanović, Nevena and Zlatar, Matija and Novaković, Irena T. and Pevec, Andrej and Radanović, Dušanka D. and Matić, Ivana Z. and Đorđić Crnogorac, Marija and Stanojković, Tatjana and Vujčić, Miroslava and Gruden, Maja and Sladić, Dušan and Anđelković, Katarina K. and Turel, Iztok and Čobeljić, Božidar",
year = "2022",
abstract = "In this paper, Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and DFT calculations. In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear penta-coordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], respectively, while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-negative and Gram-positive bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin.",
publisher = "Royal Society of Chemistry (RSC)",
journal = "Dalton Transactions",
title = "Supporting information for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4858"
}
Stevanović, N., Zlatar, M., Novaković, I. T., Pevec, A., Radanović, D. D., Matić, I. Z., Đorđić Crnogorac, M., Stanojković, T., Vujčić, M., Gruden, M., Sladić, D., Anđelković, K. K., Turel, I.,& Čobeljić, B.. (2022). Supporting information for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". in Dalton Transactions
Royal Society of Chemistry (RSC)..
https://hdl.handle.net/21.15107/rcub_cherry_4858
Stevanović N, Zlatar M, Novaković IT, Pevec A, Radanović DD, Matić IZ, Đorđić Crnogorac M, Stanojković T, Vujčić M, Gruden M, Sladić D, Anđelković KK, Turel I, Čobeljić B. Supporting information for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". in Dalton Transactions. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_4858 .
Stevanović, Nevena, Zlatar, Matija, Novaković, Irena T., Pevec, Andrej, Radanović, Dušanka D., Matić, Ivana Z., Đorđić Crnogorac, Marija, Stanojković, Tatjana, Vujčić, Miroslava, Gruden, Maja, Sladić, Dušan, Anđelković, Katarina K., Turel, Iztok, Čobeljić, Božidar, "Supporting information for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"" in Dalton Transactions (2022),
https://hdl.handle.net/21.15107/rcub_cherry_4858 .

CCDC 2110386: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"

Pevec, Andrej

(The Cambridge Crystallographic Data Centre (CCDC), 2022)

TY  - DATA
AU  - Pevec, Andrej
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4859
AB  - NAMYIN : azido-[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-(methanol)-copper tetrafluoroborate Space Group: P 21/n (14), Cell: a 7.0033(3)Å b 10.8941(3)Å c 25.6059(9)Å, α 90° β 97.242(4)° γ 90°
PB  - The Cambridge Crystallographic Data Centre (CCDC)
T1  - CCDC 2110386: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"
DO  - 10.5517/ccdc.csd.cc28v0z4
ER  - 
@misc{
author = "Pevec, Andrej",
year = "2022",
abstract = "NAMYIN : azido-[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-(methanol)-copper tetrafluoroborate Space Group: P 21/n (14), Cell: a 7.0033(3)Å b 10.8941(3)Å c 25.6059(9)Å, α 90° β 97.242(4)° γ 90°",
publisher = "The Cambridge Crystallographic Data Centre (CCDC)",
title = "CCDC 2110386: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"",
doi = "10.5517/ccdc.csd.cc28v0z4"
}
Pevec, A.. (2022). CCDC 2110386: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 
The Cambridge Crystallographic Data Centre (CCDC)..
https://doi.org/10.5517/ccdc.csd.cc28v0z4
Pevec A. CCDC 2110386: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 2022;.
doi:10.5517/ccdc.csd.cc28v0z4 .
Pevec, Andrej, "CCDC 2110386: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"" (2022),
https://doi.org/10.5517/ccdc.csd.cc28v0z4 . .

CCDC 2110387: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"

Pevec, Andrej

(The Cambridge Crystallographic Data Centre (CCDC), 2022)

TY  - DATA
AU  - Pevec, Andrej
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4860
AB  - NAMYOT : bis(μ-azido)-diazido-bis[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-di-manganese methanol solvate Space Group: P 1 (2), Cell: a 9.6427(5)Å b 10.8396(5)Å c 10.8617(8)Å, α 106.971(5)° β 103.497(5)° γ 112.469(5)°
PB  - The Cambridge Crystallographic Data Centre (CCDC)
T1  - CCDC 2110387: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"
DO  - 10.5517/ccdc.csd.cc28v106
ER  - 
@misc{
author = "Pevec, Andrej",
year = "2022",
abstract = "NAMYOT : bis(μ-azido)-diazido-bis[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-di-manganese methanol solvate Space Group: P 1 (2), Cell: a 9.6427(5)Å b 10.8396(5)Å c 10.8617(8)Å, α 106.971(5)° β 103.497(5)° γ 112.469(5)°",
publisher = "The Cambridge Crystallographic Data Centre (CCDC)",
title = "CCDC 2110387: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"",
doi = "10.5517/ccdc.csd.cc28v106"
}
Pevec, A.. (2022). CCDC 2110387: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 
The Cambridge Crystallographic Data Centre (CCDC)..
https://doi.org/10.5517/ccdc.csd.cc28v106
Pevec A. CCDC 2110387: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 2022;.
doi:10.5517/ccdc.csd.cc28v106 .
Pevec, Andrej, "CCDC 2110387: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"" (2022),
https://doi.org/10.5517/ccdc.csd.cc28v106 . .

CCDC 2110388: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"

Pevec, Andrej

(The Cambridge Crystallographic Data Centre (CCDC), 2022)

TY  - DATA
AU  - Pevec, Andrej
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4861
AB  - NAMYUZ : diazido-[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-zinc Space Group: P 21/c (14), Cell: a 13.0826(10)Å b 10.2506(7)Å c 13.1685(13)Å, α 90° β 111.237(10)° γ 90°
PB  - The Cambridge Crystallographic Data Centre (CCDC)
T1  - CCDC 2110388: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"
DO  - 10.5517/ccdc.csd.cc28v117
ER  - 
@misc{
author = "Pevec, Andrej",
year = "2022",
abstract = "NAMYUZ : diazido-[2-oxy-N,N,N-trimethyl-2-{[1-(1,3-thiazol-2-yl)ethylidene]hydrazinylidene}ethan-1-aminium]-zinc Space Group: P 21/c (14), Cell: a 13.0826(10)Å b 10.2506(7)Å c 13.1685(13)Å, α 90° β 111.237(10)° γ 90°",
publisher = "The Cambridge Crystallographic Data Centre (CCDC)",
title = "CCDC 2110388: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"",
doi = "10.5517/ccdc.csd.cc28v117"
}
Pevec, A.. (2022). CCDC 2110388: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 
The Cambridge Crystallographic Data Centre (CCDC)..
https://doi.org/10.5517/ccdc.csd.cc28v117
Pevec A. CCDC 2110388: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity". 2022;.
doi:10.5517/ccdc.csd.cc28v117 .
Pevec, Andrej, "CCDC 2110388: Experimental Crystal Structure Determination. Crystallographic data for: "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity"" (2022),
https://doi.org/10.5517/ccdc.csd.cc28v117 . .

Nickel-loaded nitrogen-doped titanate nanostructured catalysts for solar-light driven hydrogen evolution and environmental remediation

Šalipur, Hristina; Lončarević, Davor; Dostanić, Jasmina; Likozar, Blaž; Prašnikar, Anže; Manojlović, Dragan D.

(Elsevier, 2022)

TY  - JOUR
AU  - Šalipur, Hristina
AU  - Lončarević, Davor
AU  - Dostanić, Jasmina
AU  - Likozar, Blaž
AU  - Prašnikar, Anže
AU  - Manojlović, Dragan D.
PY  - 2022
UR  - https://www.sciencedirect.com/science/article/pii/S0360319922006036
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5207
AB  - In this work hydrogen production activity of a series of the nickel-loaded, nitrogen-doped titanate-based photocatalysts was tested by water splitting reaction in isopropanol-water mixture. The utilization of ammonium ions during catalyst synthesis and subsequent calcination led to successful formation of nitrogen-doped nanotubular titanates with lower sodium content, favored titanate-to-anatase transformation and enhanced textural, morphological and interface properties. The photocatalytic tests revealed that hydrogen production activity of nitrogen-doped titanates is ten times higher compared to nitrogen-free titanates. The presence of highly photoactive anatase phase, improved anatase crystallinity and lower amount of sodium ions are found to be decisive factors for increased hydrogen production activity. The optimal nickel loading was determined and the variation in photocatalytic activity with reduction temperature was explained. Stability tests gave quantitative analysis of the effects of reaction products accumulation and photocorrosion on the catalyst deactivation.
PB  - Elsevier
T2  - International Journal of Hydrogen Energy
T1  - Nickel-loaded nitrogen-doped titanate nanostructured catalysts for solar-light driven hydrogen evolution and environmental remediation
VL  - 47
IS  - 26
SP  - 12937
EP  - 12952
DO  - 10.1016/j.ijhydene.2022.02.054
ER  - 
@article{
author = "Šalipur, Hristina and Lončarević, Davor and Dostanić, Jasmina and Likozar, Blaž and Prašnikar, Anže and Manojlović, Dragan D.",
year = "2022",
abstract = "In this work hydrogen production activity of a series of the nickel-loaded, nitrogen-doped titanate-based photocatalysts was tested by water splitting reaction in isopropanol-water mixture. The utilization of ammonium ions during catalyst synthesis and subsequent calcination led to successful formation of nitrogen-doped nanotubular titanates with lower sodium content, favored titanate-to-anatase transformation and enhanced textural, morphological and interface properties. The photocatalytic tests revealed that hydrogen production activity of nitrogen-doped titanates is ten times higher compared to nitrogen-free titanates. The presence of highly photoactive anatase phase, improved anatase crystallinity and lower amount of sodium ions are found to be decisive factors for increased hydrogen production activity. The optimal nickel loading was determined and the variation in photocatalytic activity with reduction temperature was explained. Stability tests gave quantitative analysis of the effects of reaction products accumulation and photocorrosion on the catalyst deactivation.",
publisher = "Elsevier",
journal = "International Journal of Hydrogen Energy",
title = "Nickel-loaded nitrogen-doped titanate nanostructured catalysts for solar-light driven hydrogen evolution and environmental remediation",
volume = "47",
number = "26",
pages = "12937-12952",
doi = "10.1016/j.ijhydene.2022.02.054"
}
Šalipur, H., Lončarević, D., Dostanić, J., Likozar, B., Prašnikar, A.,& Manojlović, D. D.. (2022). Nickel-loaded nitrogen-doped titanate nanostructured catalysts for solar-light driven hydrogen evolution and environmental remediation. in International Journal of Hydrogen Energy
Elsevier., 47(26), 12937-12952.
https://doi.org/10.1016/j.ijhydene.2022.02.054
Šalipur H, Lončarević D, Dostanić J, Likozar B, Prašnikar A, Manojlović DD. Nickel-loaded nitrogen-doped titanate nanostructured catalysts for solar-light driven hydrogen evolution and environmental remediation. in International Journal of Hydrogen Energy. 2022;47(26):12937-12952.
doi:10.1016/j.ijhydene.2022.02.054 .
Šalipur, Hristina, Lončarević, Davor, Dostanić, Jasmina, Likozar, Blaž, Prašnikar, Anže, Manojlović, Dragan D., "Nickel-loaded nitrogen-doped titanate nanostructured catalysts for solar-light driven hydrogen evolution and environmental remediation" in International Journal of Hydrogen Energy, 47, no. 26 (2022):12937-12952,
https://doi.org/10.1016/j.ijhydene.2022.02.054 . .

The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study

Penjišević, Jelena Z.; Šukalović, Vladimir B.; Andrić, Deana; Suručić, Relja; Kostić-Rajačić, Slađana V.

(Springer, 2022)

TY  - JOUR
AU  - Penjišević, Jelena Z.
AU  - Šukalović, Vladimir B.
AU  - Andrić, Deana
AU  - Suručić, Relja
AU  - Kostić-Rajačić, Slađana V.
PY  - 2022
UR  - http://www.ncbi.nlm.nih.gov/pubmed/35507251
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5181
AB  - Adrenergic receptors are among the most studied G protein-coupled receptors. Activation or blockade of these receptors is a major therapeutic approach for the treatment of numerous disorders such as cardiac hypertrophy, congestive heart failure, hypertension, angina pectoris, cardiac arrhythmias, depression, benign prostate hyperplasia, anaphylaxis, asthma, and hyperthyroidism. Among all nine cloned adrenoceptor subtypes and the subsequent development of animal models, a significant target for various neurological conditions treatment is alpha1-adrenergic receptors. 2-{[4-(2-Methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles, their 5 substituted derivatives, and structurally similar, arylpiperazine based alpha1-adrenergic receptors antagonists (trazodone, naftopidil, and urapidil) have been subjects of comparative analysis. Most of the novel compounds showed alpha1-adrenergic affinity in the range from 22 nM to 250 nM. The in silico docking and molecular dynamics simulations, binding data together with absorption, distribution, metabolism, and excretion (ADME) calculations identified the promising lead compounds. The results brought out the conclusions which allowed us to propose a rationale for the activity of these molecules and to highlight six compounds (2-5, 8, and 12) that exhibited an acceptable pharmacokinetic profile to the advanced investigation as the potential alpha1-adrenergic receptor antagonists.
PB  - Springer
T2  - Applied Biochemistry and Biotechnology
T1  - The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study
VL  - n/a
DO  - 10.1007/s12010-022-03922-8
ER  - 
@article{
author = "Penjišević, Jelena Z. and Šukalović, Vladimir B. and Andrić, Deana and Suručić, Relja and Kostić-Rajačić, Slađana V.",
year = "2022",
abstract = "Adrenergic receptors are among the most studied G protein-coupled receptors. Activation or blockade of these receptors is a major therapeutic approach for the treatment of numerous disorders such as cardiac hypertrophy, congestive heart failure, hypertension, angina pectoris, cardiac arrhythmias, depression, benign prostate hyperplasia, anaphylaxis, asthma, and hyperthyroidism. Among all nine cloned adrenoceptor subtypes and the subsequent development of animal models, a significant target for various neurological conditions treatment is alpha1-adrenergic receptors. 2-{[4-(2-Methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles, their 5 substituted derivatives, and structurally similar, arylpiperazine based alpha1-adrenergic receptors antagonists (trazodone, naftopidil, and urapidil) have been subjects of comparative analysis. Most of the novel compounds showed alpha1-adrenergic affinity in the range from 22 nM to 250 nM. The in silico docking and molecular dynamics simulations, binding data together with absorption, distribution, metabolism, and excretion (ADME) calculations identified the promising lead compounds. The results brought out the conclusions which allowed us to propose a rationale for the activity of these molecules and to highlight six compounds (2-5, 8, and 12) that exhibited an acceptable pharmacokinetic profile to the advanced investigation as the potential alpha1-adrenergic receptor antagonists.",
publisher = "Springer",
journal = "Applied Biochemistry and Biotechnology",
title = "The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study",
volume = "n/a",
doi = "10.1007/s12010-022-03922-8"
}
Penjišević, J. Z., Šukalović, V. B., Andrić, D., Suručić, R.,& Kostić-Rajačić, S. V.. (2022). The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study. in Applied Biochemistry and Biotechnology
Springer., n/a.
https://doi.org/10.1007/s12010-022-03922-8
Penjišević JZ, Šukalović VB, Andrić D, Suručić R, Kostić-Rajačić SV. The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study. in Applied Biochemistry and Biotechnology. 2022;n/a.
doi:10.1007/s12010-022-03922-8 .
Penjišević, Jelena Z., Šukalović, Vladimir B., Andrić, Deana, Suručić, Relja, Kostić-Rajačić, Slađana V., "The Therapeutic Potential of 2-{[4-(2-methoxyphenyl)piperazin-1-yl]alkyl}-1H-benzo[d]imidazoles as Ligands for Alpha1-Adrenergic Receptor - Comparative In Silico and In Vitro Study" in Applied Biochemistry and Biotechnology, n/a (2022),
https://doi.org/10.1007/s12010-022-03922-8 . .

Evaluation of antitumor potential of Cu(II) complex with hydrazone of 2-acetylthiazole and Girard’s T reagent

Stevanović, Nevena; Jevtović, Mima; Mitić, Dragana; Matić, Ivana Z.; Crnogorac, Marija Đ.; Vujčić, Miroslava; Sladić, Dušan; Čobeljić, Božidar; Anđelković, Katarina K.

(Beograd : Srpsko hemijsko društvo, 2022)

TY  - JOUR
AU  - Stevanović, Nevena
AU  - Jevtović, Mima
AU  - Mitić, Dragana
AU  - Matić, Ivana Z.
AU  - Crnogorac, Marija Đ.
AU  - Vujčić, Miroslava
AU  - Sladić, Dušan
AU  - Čobeljić, Božidar
AU  - Anđelković, Katarina K.
PY  - 2022
UR  - http://www.doiserbia.nb.rs/img/doi/0352-5139/2022/0352-51392202181S.pdf
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5154
AB  - In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.
PB  - Beograd : Srpsko hemijsko društvo
T1  - Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent
VL  - 87
IS  - 2
SP  - 181
EP  - 192
DO  - 10.2298/JSC211203114S
ER  - 
@article{
author = "Stevanović, Nevena and Jevtović, Mima and Mitić, Dragana and Matić, Ivana Z. and Crnogorac, Marija Đ. and Vujčić, Miroslava and Sladić, Dušan and Čobeljić, Božidar and Anđelković, Katarina K.",
year = "2022",
abstract = "In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.",
publisher = "Beograd : Srpsko hemijsko društvo",
title = "Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent",
volume = "87",
number = "2",
pages = "181-192",
doi = "10.2298/JSC211203114S"
}
Stevanović, N., Jevtović, M., Mitić, D., Matić, I. Z., Crnogorac, M. Đ., Vujčić, M., Sladić, D., Čobeljić, B.,& Anđelković, K. K.. (2022). Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent. 
Beograd : Srpsko hemijsko društvo., 87(2), 181-192.
https://doi.org/10.2298/JSC211203114S
Stevanović N, Jevtović M, Mitić D, Matić IZ, Crnogorac MĐ, Vujčić M, Sladić D, Čobeljić B, Anđelković KK. Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent. 2022;87(2):181-192.
doi:10.2298/JSC211203114S .
Stevanović, Nevena, Jevtović, Mima, Mitić, Dragana, Matić, Ivana Z., Crnogorac, Marija Đ., Vujčić, Miroslava, Sladić, Dušan, Čobeljić, Božidar, Anđelković, Katarina K., "Evaluation of antitumor potential of Cu(II) complex with
hydrazone of 2-acetylthiazole and Girard’s T reagent", 87, no. 2 (2022):181-192,
https://doi.org/10.2298/JSC211203114S . .

Characterization of the organic matter in sediments of the Great War Island (Belgrade, Serbia)

Stojadinović, Sanja M.; Šajnović, Aleksandra; Kašanin-Grubin, Milica; Gajica, Gordana; Veselinović, Gorica; Štrbac, Snežana; Jovančićević, Branimir

(Springer, 2022)

TY  - JOUR
AU  - Stojadinović, Sanja M.
AU  - Šajnović, Aleksandra
AU  - Kašanin-Grubin, Milica
AU  - Gajica, Gordana
AU  - Veselinović, Gorica
AU  - Štrbac, Snežana
AU  - Jovančićević, Branimir
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5079
AB  - Abstract
Purpose The Great War Island (GWI) is a landform of exceptional features and a protected area located in the center of
Belgrade at the Sava and Danube River’s confluence. The position of GWI causes a large number of possible hydrocar-
bons inputs that influence the quality of both river waters and sediments. The main objective of this research is to assess
the distribution and source of hydrocarbons in sediments deposited at the GWI depending on the river’s flow regimes and
depositional environment.
Material and methods Sediment samples were collected from 16 sites (11 sites along the GWI’s coast, 4 sites from the
inner of the Island, and 1 specific wetland site). The grain size was determined using a standard wet sieving procedure. The
extractable organic matter (OM) was quantified after Soxhlet extraction, and aliphatic and aromatic fractions were isolated
by column chromatography. n-Alkanes, diterpanes, terpanes, steranes, and 16 PAHs are analyzed by gas chromatography-
mass spectrometry.
Results and discussion Sand fraction predominates in coastal samples, and clay size fraction in the samples from the inner
island environment. The predominance of odd higher n-alkanes indicates the terrestrial origin of OM, while the distribution
of lower n-alkanes indicates a certain proportion of algae, bacteria, and/or high maturity of OM. The presence of oil-type
pollutants is confirmed by thermodynamically stable biomarker isomers and/or the presence of unresolved complex mixture
(UCM). Inner island samples are characterized by the largest amount of Corg (up 6%), indicating high bioproductivity and
good preservation of OM. Samples from wetland environment are distinguished by the domination of pimaranes and phyl-
locladanes among saturated hydrocarbons.
Conclusions This study revealed that sediments of the GWI mainly contain native OM with a certain anthropogenic input.
The native OM predominately comes from higher terrestrial plants (Salix alba, Populus nigra, Fraxinus viridis, Taxodium
distichum Rich.), followed by various types of grasses, macrophytes (Salvinia natans, Nymphaea alba), bacteria, algae, and
phytoplankton. Anthropogenic OM originates from petroleum, but also combustion products arrived by deposition from
the air and runoff.
PB  - Springer
T2  - Journal of Soils and Sediments
T1  - Characterization of the organic matter in sediments of the Great War Island (Belgrade, Serbia)
VL  - 22
SP  - 640
EP  - 655
DO  - 10.1007/s11368-021-03103-w
ER  - 
@article{
author = "Stojadinović, Sanja M. and Šajnović, Aleksandra and Kašanin-Grubin, Milica and Gajica, Gordana and Veselinović, Gorica and Štrbac, Snežana and Jovančićević, Branimir",
year = "2022",
abstract = "Abstract
Purpose The Great War Island (GWI) is a landform of exceptional features and a protected area located in the center of
Belgrade at the Sava and Danube River’s confluence. The position of GWI causes a large number of possible hydrocar-
bons inputs that influence the quality of both river waters and sediments. The main objective of this research is to assess
the distribution and source of hydrocarbons in sediments deposited at the GWI depending on the river’s flow regimes and
depositional environment.
Material and methods Sediment samples were collected from 16 sites (11 sites along the GWI’s coast, 4 sites from the
inner of the Island, and 1 specific wetland site). The grain size was determined using a standard wet sieving procedure. The
extractable organic matter (OM) was quantified after Soxhlet extraction, and aliphatic and aromatic fractions were isolated
by column chromatography. n-Alkanes, diterpanes, terpanes, steranes, and 16 PAHs are analyzed by gas chromatography-
mass spectrometry.
Results and discussion Sand fraction predominates in coastal samples, and clay size fraction in the samples from the inner
island environment. The predominance of odd higher n-alkanes indicates the terrestrial origin of OM, while the distribution
of lower n-alkanes indicates a certain proportion of algae, bacteria, and/or high maturity of OM. The presence of oil-type
pollutants is confirmed by thermodynamically stable biomarker isomers and/or the presence of unresolved complex mixture
(UCM). Inner island samples are characterized by the largest amount of Corg (up 6%), indicating high bioproductivity and
good preservation of OM. Samples from wetland environment are distinguished by the domination of pimaranes and phyl-
locladanes among saturated hydrocarbons.
Conclusions This study revealed that sediments of the GWI mainly contain native OM with a certain anthropogenic input.
The native OM predominately comes from higher terrestrial plants (Salix alba, Populus nigra, Fraxinus viridis, Taxodium
distichum Rich.), followed by various types of grasses, macrophytes (Salvinia natans, Nymphaea alba), bacteria, algae, and
phytoplankton. Anthropogenic OM originates from petroleum, but also combustion products arrived by deposition from
the air and runoff.",
publisher = "Springer",
journal = "Journal of Soils and Sediments",
title = "Characterization of the organic matter in sediments of the Great War Island (Belgrade, Serbia)",
volume = "22",
pages = "640-655",
doi = "10.1007/s11368-021-03103-w"
}
Stojadinović, S. M., Šajnović, A., Kašanin-Grubin, M., Gajica, G., Veselinović, G., Štrbac, S.,& Jovančićević, B.. (2022). Characterization of the organic matter in sediments of the Great War Island (Belgrade, Serbia). in Journal of Soils and Sediments
Springer., 22, 640-655.
https://doi.org/10.1007/s11368-021-03103-w
Stojadinović SM, Šajnović A, Kašanin-Grubin M, Gajica G, Veselinović G, Štrbac S, Jovančićević B. Characterization of the organic matter in sediments of the Great War Island (Belgrade, Serbia). in Journal of Soils and Sediments. 2022;22:640-655.
doi:10.1007/s11368-021-03103-w .
Stojadinović, Sanja M., Šajnović, Aleksandra, Kašanin-Grubin, Milica, Gajica, Gordana, Veselinović, Gorica, Štrbac, Snežana, Jovančićević, Branimir, "Characterization of the organic matter in sediments of the Great War Island (Belgrade, Serbia)" in Journal of Soils and Sediments, 22 (2022):640-655,
https://doi.org/10.1007/s11368-021-03103-w . .

Microbial fuel cells as an electrical energy source for degradation followed by decolorization of Reactive Black 5 azo dye

Joksimović, Kristina; Kodranov, Igor D.; Randjelović, Danijela; Slavković-Beškoski, Latinka; Radulović, Jelena; Lješević, Marija; Manojlović, Dragan D.; Beškoski, Vladimir

(2022)

TY  - JOUR
AU  - Joksimović, Kristina
AU  - Kodranov, Igor D.
AU  - Randjelović, Danijela
AU  - Slavković-Beškoski, Latinka
AU  - Radulović, Jelena
AU  - Lješević, Marija
AU  - Manojlović, Dragan D.
AU  - Beškoski, Vladimir
PY  - 2022
UR  - https://www.sciencedirect.com/science/article/pii/S1567539422000391
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5045
AB  - The problem of wastewater has long been ubiquitous and has great consequences for the environment and its inhabitants. Microbial fuel cells (MFCs) have enormous potential for the treatment of wastewaters polluted with azo dyes. The amount of energy that can be produced from a single-chamber MFC is sufficient to perform decolorization and degradation of such dyes, which are widely used in the textile industry. This study on the azo dye, reactive black 5 (RB5), provides an alternative method through three parallel-connected MFCs to obtain electricity that directly serves for the dye’s electrochemical degradation. We examined degradation followed by decolorization of RB5 using Fe and Pt electrodes, together with H2O2, to achieve the electro-Fenton process. The amount of voltage produced (295 mV), the current density (276 mA m−3) and the power density (50 mW m−3) were sufficient to degrade 25 mg L-1 RB5 dye with 0.5 mM H2O2 in just 2 h. The dye degradation mechanism was investigated using UV–VIS, FT-IR and HPLC-MS/MS. The ecotoxicity of the degradation products was assessed using a bacterial model, Aliivibrio fischeri. These tests showed that there was successful degradation of the dye to products whose toxicity is less than that of RB5.
T2  - Bioelectrochemistry
T1  - Microbial fuel cells as an electrical energy source for degradation followed by decolorization of Reactive Black 5 azo dye
VL  - 145
SP  - 108088
DO  - 10.1016/j.bioelechem.2022.108088
ER  - 
@article{
author = "Joksimović, Kristina and Kodranov, Igor D. and Randjelović, Danijela and Slavković-Beškoski, Latinka and Radulović, Jelena and Lješević, Marija and Manojlović, Dragan D. and Beškoski, Vladimir",
year = "2022",
abstract = "The problem of wastewater has long been ubiquitous and has great consequences for the environment and its inhabitants. Microbial fuel cells (MFCs) have enormous potential for the treatment of wastewaters polluted with azo dyes. The amount of energy that can be produced from a single-chamber MFC is sufficient to perform decolorization and degradation of such dyes, which are widely used in the textile industry. This study on the azo dye, reactive black 5 (RB5), provides an alternative method through three parallel-connected MFCs to obtain electricity that directly serves for the dye’s electrochemical degradation. We examined degradation followed by decolorization of RB5 using Fe and Pt electrodes, together with H2O2, to achieve the electro-Fenton process. The amount of voltage produced (295 mV), the current density (276 mA m−3) and the power density (50 mW m−3) were sufficient to degrade 25 mg L-1 RB5 dye with 0.5 mM H2O2 in just 2 h. The dye degradation mechanism was investigated using UV–VIS, FT-IR and HPLC-MS/MS. The ecotoxicity of the degradation products was assessed using a bacterial model, Aliivibrio fischeri. These tests showed that there was successful degradation of the dye to products whose toxicity is less than that of RB5.",
journal = "Bioelectrochemistry",
title = "Microbial fuel cells as an electrical energy source for degradation followed by decolorization of Reactive Black 5 azo dye",
volume = "145",
pages = "108088",
doi = "10.1016/j.bioelechem.2022.108088"
}
Joksimović, K., Kodranov, I. D., Randjelović, D., Slavković-Beškoski, L., Radulović, J., Lješević, M., Manojlović, D. D.,& Beškoski, V.. (2022). Microbial fuel cells as an electrical energy source for degradation followed by decolorization of Reactive Black 5 azo dye. in Bioelectrochemistry, 145, 108088.
https://doi.org/10.1016/j.bioelechem.2022.108088
Joksimović K, Kodranov ID, Randjelović D, Slavković-Beškoski L, Radulović J, Lješević M, Manojlović DD, Beškoski V. Microbial fuel cells as an electrical energy source for degradation followed by decolorization of Reactive Black 5 azo dye. in Bioelectrochemistry. 2022;145:108088.
doi:10.1016/j.bioelechem.2022.108088 .
Joksimović, Kristina, Kodranov, Igor D., Randjelović, Danijela, Slavković-Beškoski, Latinka, Radulović, Jelena, Lješević, Marija, Manojlović, Dragan D., Beškoski, Vladimir, "Microbial fuel cells as an electrical energy source for degradation followed by decolorization of Reactive Black 5 azo dye" in Bioelectrochemistry, 145 (2022):108088,
https://doi.org/10.1016/j.bioelechem.2022.108088 . .
1
1

Spatial–temporal assessment of hydrocarbon biodegradation mechanisms at a contaminated groundwater site in Serbia

Marić, Nenad; Štrbački, Jana; Polk, Jason; Slavković-Beškoski, Latinka; Avdalović, Jelena; Lješević, Marija; Joksimović, Kristina; Žerađanin, Aleksandra; Beškoski, Vladimir

(England: Taylor and Francis, 2022)

TY  - JOUR
AU  - Marić, Nenad
AU  - Štrbački, Jana
AU  - Polk, Jason
AU  - Slavković-Beškoski, Latinka
AU  - Avdalović, Jelena
AU  - Lješević, Marija
AU  - Joksimović, Kristina
AU  - Žerađanin, Aleksandra
AU  - Beškoski, Vladimir
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5250
AB  - The characterization and cleanup of groundwater contamination in hazardous-waste sites are of significant engineering and scientific importance. This study analyzes biodegradation fingerprints in groundwater, 25 years after the accidental leakage of kerosene (jet fuel) at the site in central Serbia. The long-term existence of hydrocarbon contamination and the presence of indigenous microbiological populations capable of biodegradation have been confirmed by the results of GCxGC-MS chromatography and microbiological characterization. Total petroleum hydrocarbons (TPH), geochemical indicators, and other parameters were spatially analyzed to provide insight into biodegradation occurrence. The lowest concentrations of electron acceptors (O2, NO3-, and SO42-) and the highest concentrations of microbial metabolic products (Mn and Fe) overlap in the piezometers closest to the source of contamination, due to the occurrence of different biodegradation mechanisms. Based on the analysis of redox-sensitive compounds, the mixed oxic-anoxic processes in groundwater also correspond to the aforementioned zone, as confirmed by the redox potential (Eh) measurements. The results of cross-study analysis reveal further reduction of hydrocarbon contamination, the occurrence of less anoxic redox processes, and the increase of oxic conditions in groundwater. Overall, the results provide clear evidence of the biodegradation effects in groundwater and insight into their evolution under natural attenuation processes.
PB  - England: Taylor and Francis
T2  - Chemistry and Ecology
T1  - Spatial–temporal assessment of hydrocarbon biodegradation mechanisms at a contaminated groundwater site in Serbia
VL  - 38
IS  - 2
SP  - 95
EP  - 107
DO  - 10.1080/02757540.2021.2017903
ER  - 
@article{
author = "Marić, Nenad and Štrbački, Jana and Polk, Jason and Slavković-Beškoski, Latinka and Avdalović, Jelena and Lješević, Marija and Joksimović, Kristina and Žerađanin, Aleksandra and Beškoski, Vladimir",
year = "2022",
abstract = "The characterization and cleanup of groundwater contamination in hazardous-waste sites are of significant engineering and scientific importance. This study analyzes biodegradation fingerprints in groundwater, 25 years after the accidental leakage of kerosene (jet fuel) at the site in central Serbia. The long-term existence of hydrocarbon contamination and the presence of indigenous microbiological populations capable of biodegradation have been confirmed by the results of GCxGC-MS chromatography and microbiological characterization. Total petroleum hydrocarbons (TPH), geochemical indicators, and other parameters were spatially analyzed to provide insight into biodegradation occurrence. The lowest concentrations of electron acceptors (O2, NO3-, and SO42-) and the highest concentrations of microbial metabolic products (Mn and Fe) overlap in the piezometers closest to the source of contamination, due to the occurrence of different biodegradation mechanisms. Based on the analysis of redox-sensitive compounds, the mixed oxic-anoxic processes in groundwater also correspond to the aforementioned zone, as confirmed by the redox potential (Eh) measurements. The results of cross-study analysis reveal further reduction of hydrocarbon contamination, the occurrence of less anoxic redox processes, and the increase of oxic conditions in groundwater. Overall, the results provide clear evidence of the biodegradation effects in groundwater and insight into their evolution under natural attenuation processes.",
publisher = "England: Taylor and Francis",
journal = "Chemistry and Ecology",
title = "Spatial–temporal assessment of hydrocarbon biodegradation mechanisms at a contaminated groundwater site in Serbia",
volume = "38",
number = "2",
pages = "95-107",
doi = "10.1080/02757540.2021.2017903"
}
Marić, N., Štrbački, J., Polk, J., Slavković-Beškoski, L., Avdalović, J., Lješević, M., Joksimović, K., Žerađanin, A.,& Beškoski, V.. (2022). Spatial–temporal assessment of hydrocarbon biodegradation mechanisms at a contaminated groundwater site in Serbia. in Chemistry and Ecology
England: Taylor and Francis., 38(2), 95-107.
https://doi.org/10.1080/02757540.2021.2017903
Marić N, Štrbački J, Polk J, Slavković-Beškoski L, Avdalović J, Lješević M, Joksimović K, Žerađanin A, Beškoski V. Spatial–temporal assessment of hydrocarbon biodegradation mechanisms at a contaminated groundwater site in Serbia. in Chemistry and Ecology. 2022;38(2):95-107.
doi:10.1080/02757540.2021.2017903 .
Marić, Nenad, Štrbački, Jana, Polk, Jason, Slavković-Beškoski, Latinka, Avdalović, Jelena, Lješević, Marija, Joksimović, Kristina, Žerađanin, Aleksandra, Beškoski, Vladimir, "Spatial–temporal assessment of hydrocarbon biodegradation mechanisms at a contaminated groundwater site in Serbia" in Chemistry and Ecology, 38, no. 2 (2022):95-107,
https://doi.org/10.1080/02757540.2021.2017903 . .

To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries

Popović, Aleksandar R.; Anđelković, Boban D.; Đorđević, Dragana S.; Sakan, Sanja M.; Vujisić, Ljubodrag V.; Veličković, Sava; Relić, Dubravka

(2022)

TY  - JOUR
AU  - Popović, Aleksandar R.
AU  - Anđelković, Boban D.
AU  - Đorđević, Dragana S.
AU  - Sakan, Sanja M.
AU  - Vujisić, Ljubodrag V.
AU  - Veličković, Sava
AU  - Relić, Dubravka
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4942
AB  - In order to further define the potential use of FTIR-ATR spectroscopy, as a non-destructive and reliable technique, for the analysis of the characteristics of post stamps, certified originals of the Principality of Serbia stamps (“Prince Michael issues”) issued in 1866 and 1868 as well as their forgeries were ana­lyzed. Spectra enabling the comparison of the paper, dye and glue of stamps of so-called “Vienna issues”, having denominations of 10 (orange-yellow), 20 (pink) and 40 para (blue) and “Belgrade issues” (1 para-green and 2 para-reddish brown), as well as 24 expert-certified forgeries, were taken. It was shown that the applied technology was, in most of the cases, a fast and suitable technique for establishing clear differences between the spectral characteristics of the paper and dye used for the original stamps, and forgeries that were most probably made decades after the printing of the genuine stamps. The differences between print­ings of the same issues of the genuine stamps were also elaborated. It is pro­posed, for the first time in philatelic history, the possibility that “Vienna issues” stamps may have been printed on two different papers, and, having in mind the technology of printing in the 19th century, potentially, not even at the same time or in the same printing house.
T2  - Journal of the Serbian Chemical Society
T1  - To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries
VL  - 87
IS  - 1
SP  - 27
EP  - 40
DO  - 10.2298/JSC210901090P
ER  - 
@article{
author = "Popović, Aleksandar R. and Anđelković, Boban D. and Đorđević, Dragana S. and Sakan, Sanja M. and Vujisić, Ljubodrag V. and Veličković, Sava and Relić, Dubravka",
year = "2022",
abstract = "In order to further define the potential use of FTIR-ATR spectroscopy, as a non-destructive and reliable technique, for the analysis of the characteristics of post stamps, certified originals of the Principality of Serbia stamps (“Prince Michael issues”) issued in 1866 and 1868 as well as their forgeries were ana­lyzed. Spectra enabling the comparison of the paper, dye and glue of stamps of so-called “Vienna issues”, having denominations of 10 (orange-yellow), 20 (pink) and 40 para (blue) and “Belgrade issues” (1 para-green and 2 para-reddish brown), as well as 24 expert-certified forgeries, were taken. It was shown that the applied technology was, in most of the cases, a fast and suitable technique for establishing clear differences between the spectral characteristics of the paper and dye used for the original stamps, and forgeries that were most probably made decades after the printing of the genuine stamps. The differences between print­ings of the same issues of the genuine stamps were also elaborated. It is pro­posed, for the first time in philatelic history, the possibility that “Vienna issues” stamps may have been printed on two different papers, and, having in mind the technology of printing in the 19th century, potentially, not even at the same time or in the same printing house.",
journal = "Journal of the Serbian Chemical Society",
title = "To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries",
volume = "87",
number = "1",
pages = "27-40",
doi = "10.2298/JSC210901090P"
}
Popović, A. R., Anđelković, B. D., Đorđević, D. S., Sakan, S. M., Vujisić, L. V., Veličković, S.,& Relić, D.. (2022). To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries. in Journal of the Serbian Chemical Society, 87(1), 27-40.
https://doi.org/10.2298/JSC210901090P
Popović AR, Anđelković BD, Đorđević DS, Sakan SM, Vujisić LV, Veličković S, Relić D. To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries. in Journal of the Serbian Chemical Society. 2022;87(1):27-40.
doi:10.2298/JSC210901090P .
Popović, Aleksandar R., Anđelković, Boban D., Đorđević, Dragana S., Sakan, Sanja M., Vujisić, Ljubodrag V., Veličković, Sava, Relić, Dubravka, "To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries" in Journal of the Serbian Chemical Society, 87, no. 1 (2022):27-40,
https://doi.org/10.2298/JSC210901090P . .

Bioremediation of river sediment polluted with polychlorinated biphenyls: A laboratory study

Žerađanin, Aleksandra; Joksimović, Kristina; Avdalović, Jelena; Gojgić-Cvijović, Gordana; Nakano, Takeshi; Miletić, Srđan; Ilić, Mila; Beškoski, Vladimir

(Belgrade : Serbian Chemical Society, 2022)

TY  - JOUR
AU  - Žerađanin, Aleksandra
AU  - Joksimović, Kristina
AU  - Avdalović, Jelena
AU  - Gojgić-Cvijović, Gordana
AU  - Nakano, Takeshi
AU  - Miletić, Srđan
AU  - Ilić, Mila
AU  - Beškoski, Vladimir
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5396
AB  - Persistent organic pollutants (POPs) are lipophilic, constant and bioaccumulative toxic compounds. In general, they are considered resistant to biological, photolytic, and chemical degradation with polychlorinated biphenyls (PCBs) belonging to these chemicals. PCBs were never produced in Serbia, but they were imported and mainly used in electrical equipment, transformers, and capacitors. Our study aimed to analyse sequential multi-stage aerobic/anaerobic microbial biodegradation of PCBs present in the river sediment from the area known for long-term pollution with these chemicals. The study with an autochthonous natural microbial community (NMC model system) and NMC augmented with allochthonous hydrocarbon-degrading (AHD) microorganisms (isolated from location contaminated with petroleum products) (NMC-AHD model system) was performed in order to estimate the potential of these microorganisms for possible use in future bioremediation treatment of these sites. The laboratory biodegradation study lasted 70 days, after which an overall >33 % reduction in the concentration of total PCBs was observed. This study confirmed the strong potential of the NMC for the reduction of the level of PCBs in the river sediment under alternating multi-stage aerobic/anaerobic conditions.
AB  - Дуготрајне органске загађујуће супстанце (POPs) су липофилна, постојана и биоакумулативна токсична једињења. Уопштено говорећи, сматрају се отпорним на биолошку, фотолитичку и хемијску деградацију, а полихлоровани бифенили (PCBs) спадају у групу ових хемикалија. У Србији се PCBs никада нису производили, али су се увозили и углавном користили у електроопреми, трансформаторима и кондензаторима. Циљнашег истраживања био је да се анализира секвенцијална вишестепена аеробна/анаеробна микробиолошка разградња PCBs присутних у речном седименту са подручја познатог по дуготрајном загађењу овим једињењима. Проучавање активности конзорцијума аутохтоних природно присутних микроорганизама (NMC конзорцијум) и NMC суплементисаних конзорцијумом алохтоних угљоводоник деградирајућих (HD) микроорганизама (изолованих са локација контаминираних нафтним дериватима) (NMC-HD конзорцијум) је изведено како би се проценила способност ових микроорганизама за потренцијалну употребу у будућим биоремедијационим третманима оваквих локалитета. Лабораторијска студија биоразградње је трајала 70 дана, након чега је уочено смањење концентрације укупних PCBs за >33 %. Ово истраживање је потврдило снажан потенцијал аутохтоних микроорганизама за смањење нивоа PCBs у речном седименту у наизменичним вишестепеним аеробним/анаеробним условима.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Bioremediation of river sediment polluted with polychlorinated biphenyls: A laboratory study
T1  - Биодеградација полихлорованих бифенила у речном седименту: лабораторијска студија
VL  - 87
IS  - 1
SP  - 95
EP  - 107
DO  - 10.2298/JSC211217113Z
ER  - 
@article{
author = "Žerađanin, Aleksandra and Joksimović, Kristina and Avdalović, Jelena and Gojgić-Cvijović, Gordana and Nakano, Takeshi and Miletić, Srđan and Ilić, Mila and Beškoski, Vladimir",
year = "2022",
abstract = "Persistent organic pollutants (POPs) are lipophilic, constant and bioaccumulative toxic compounds. In general, they are considered resistant to biological, photolytic, and chemical degradation with polychlorinated biphenyls (PCBs) belonging to these chemicals. PCBs were never produced in Serbia, but they were imported and mainly used in electrical equipment, transformers, and capacitors. Our study aimed to analyse sequential multi-stage aerobic/anaerobic microbial biodegradation of PCBs present in the river sediment from the area known for long-term pollution with these chemicals. The study with an autochthonous natural microbial community (NMC model system) and NMC augmented with allochthonous hydrocarbon-degrading (AHD) microorganisms (isolated from location contaminated with petroleum products) (NMC-AHD model system) was performed in order to estimate the potential of these microorganisms for possible use in future bioremediation treatment of these sites. The laboratory biodegradation study lasted 70 days, after which an overall >33 % reduction in the concentration of total PCBs was observed. This study confirmed the strong potential of the NMC for the reduction of the level of PCBs in the river sediment under alternating multi-stage aerobic/anaerobic conditions., Дуготрајне органске загађујуће супстанце (POPs) су липофилна, постојана и биоакумулативна токсична једињења. Уопштено говорећи, сматрају се отпорним на биолошку, фотолитичку и хемијску деградацију, а полихлоровани бифенили (PCBs) спадају у групу ових хемикалија. У Србији се PCBs никада нису производили, али су се увозили и углавном користили у електроопреми, трансформаторима и кондензаторима. Циљнашег истраживања био је да се анализира секвенцијална вишестепена аеробна/анаеробна микробиолошка разградња PCBs присутних у речном седименту са подручја познатог по дуготрајном загађењу овим једињењима. Проучавање активности конзорцијума аутохтоних природно присутних микроорганизама (NMC конзорцијум) и NMC суплементисаних конзорцијумом алохтоних угљоводоник деградирајућих (HD) микроорганизама (изолованих са локација контаминираних нафтним дериватима) (NMC-HD конзорцијум) је изведено како би се проценила способност ових микроорганизама за потренцијалну употребу у будућим биоремедијационим третманима оваквих локалитета. Лабораторијска студија биоразградње је трајала 70 дана, након чега је уочено смањење концентрације укупних PCBs за >33 %. Ово истраживање је потврдило снажан потенцијал аутохтоних микроорганизама за смањење нивоа PCBs у речном седименту у наизменичним вишестепеним аеробним/анаеробним условима.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Bioremediation of river sediment polluted with polychlorinated biphenyls: A laboratory study, Биодеградација полихлорованих бифенила у речном седименту: лабораторијска студија",
volume = "87",
number = "1",
pages = "95-107",
doi = "10.2298/JSC211217113Z"
}
Žerađanin, A., Joksimović, K., Avdalović, J., Gojgić-Cvijović, G., Nakano, T., Miletić, S., Ilić, M.,& Beškoski, V.. (2022). Bioremediation of river sediment polluted with polychlorinated biphenyls: A laboratory study. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 87(1), 95-107.
https://doi.org/10.2298/JSC211217113Z
Žerađanin A, Joksimović K, Avdalović J, Gojgić-Cvijović G, Nakano T, Miletić S, Ilić M, Beškoski V. Bioremediation of river sediment polluted with polychlorinated biphenyls: A laboratory study. in Journal of the Serbian Chemical Society. 2022;87(1):95-107.
doi:10.2298/JSC211217113Z .
Žerađanin, Aleksandra, Joksimović, Kristina, Avdalović, Jelena, Gojgić-Cvijović, Gordana, Nakano, Takeshi, Miletić, Srđan, Ilić, Mila, Beškoski, Vladimir, "Bioremediation of river sediment polluted with polychlorinated biphenyls: A laboratory study" in Journal of the Serbian Chemical Society, 87, no. 1 (2022):95-107,
https://doi.org/10.2298/JSC211217113Z . .

Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.

Stevanović, Nevena; Jevtović, Mima; Mitić, Dragana; Matić, Ivana Z.; Crnogorac, Marija Đ.; Vujčić, Miroslava; Sladić, Dušan; Čobeljić, Božidar; Anđelković, Katarina K.

(Beograd : Srpsko hemijsko društvo, 2022)

TY  - DATA
AU  - Stevanović, Nevena
AU  - Jevtović, Mima
AU  - Mitić, Dragana
AU  - Matić, Ivana Z.
AU  - Crnogorac, Marija Đ.
AU  - Vujčić, Miroslava
AU  - Sladić, Dušan
AU  - Čobeljić, Božidar
AU  - Anđelković, Katarina K.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5154
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5155
AB  - In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.
PB  - Beograd : Srpsko hemijsko društvo
T1  - Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5155
ER  - 
@misc{
author = "Stevanović, Nevena and Jevtović, Mima and Mitić, Dragana and Matić, Ivana Z. and Crnogorac, Marija Đ. and Vujčić, Miroslava and Sladić, Dušan and Čobeljić, Božidar and Anđelković, Katarina K.",
year = "2022",
abstract = "In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biological activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol molecule. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. © 2022 Serbian Chemical Society. All rights reserved.",
publisher = "Beograd : Srpsko hemijsko društvo",
title = "Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5155"
}
Stevanović, N., Jevtović, M., Mitić, D., Matić, I. Z., Crnogorac, M. Đ., Vujčić, M., Sladić, D., Čobeljić, B.,& Anđelković, K. K.. (2022). Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.. 
Beograd : Srpsko hemijsko društvo..
https://hdl.handle.net/21.15107/rcub_cherry_5155
Stevanović N, Jevtović M, Mitić D, Matić IZ, Crnogorac MĐ, Vujčić M, Sladić D, Čobeljić B, Anđelković KK. Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S.. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_5155 .
Stevanović, Nevena, Jevtović, Mima, Mitić, Dragana, Matić, Ivana Z., Crnogorac, Marija Đ., Vujčić, Miroslava, Sladić, Dušan, Čobeljić, Božidar, Anđelković, Katarina K., "Supplementary information for the article: Stevanović, N.; Jevtović, M.; Mitić, D.; Matić, I. Z.; Crnogorac, M. Đ.; Vujčić, M.; Sladić, D.; Čobeljić, B.; Anđelković, K. Evaluation of Antitumor Potential of Cu(II) Complex with Hydrazone of 2-Acetylthiazole and Girard’s T Reagent. Journal of the Serbian Chemical Society 2022, 87 (2), 181–192. https://doi.org/10.2298/JSC211203114S." (2022),
https://hdl.handle.net/21.15107/rcub_cherry_5155 .

A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems)

Gajica, Gordana; Šajnović, Aleksandra; Stojanović, Ksenija A.; Schwarzbauer, Jan; Kostić, Aleksandar; Jovančićević, Branimir

(Elsevier, 2022)

TY  - JOUR
AU  - Gajica, Gordana
AU  - Šajnović, Aleksandra
AU  - Stojanović, Ksenija A.
AU  - Schwarzbauer, Jan
AU  - Kostić, Aleksandar
AU  - Jovančićević, Branimir
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4846
AB  - The molecular and isotopic composition of biomarkers in initial bitumen isolated from immature (0.41% Rr) oil shale samples (Aleksinac deposit) and liquid products obtained by pyrolysis in open (OS) and closed (CS) systems are studied. The influence of pyrolysis type and variations of kerogen type on biomarkers composition and their isotopic signatures in liquid products is determined. The applicability of pyrolysis type, numerous biomarkers and carbon isotopic compositions (δ13C) of n-alkanes in liquid pyrolysates is established. Pyrolysis experiments were performed on two selected samples that showed high content of total organic carbon and hydrocarbon generation potential, but also certain variations in sources/depositional environment of organic matter (type I and mixed type I/II kerogen) within previous research of the oil shales sample set. The biomarker signatures were evaluated using gas chromatography-mass spectrometry (GC-MS) and δ13C of individual n-alkanes in bitumen and liquid pyrolysates. The molecular composition of liquid pyrolysates from the OS is very similar to those in initial bitumen, independently on kerogen type, confirming algal origin of organic matter (OM) deposited in lacustrine environment, even more apparently than results of initial bitumen. Therefore, OS can be useful for assessment of source and depositional environment of OM. Pyrolysis in the CS caused more intense thermal alterations, therefore the source fingerprints sometimes notably disappear. The liquid pyrolysates from the CS have the distributions of biomarkers similar to those in crude oils. The biomarker maturity parameters showed slightly higher values in the CS pyrolysate of mixed type I/II kerogen in relation to type I kerogen. δ13C of n-alkanes in liquid pyrolysates from the OS are isotopically lighter in comparison to bitumen, independently on kerogen type. Oppositely, in liquid pyrolysates from the CS, they become heavier than in bitumen, indicating the thermal influence on δ13C signatures, with more pronounced difference for type I kerogen.
PB  - Elsevier
T2  - Marine and Petroleum Geology
T1  - A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems)
VL  - 136
SP  - 105383
DO  - 10.1016/j.marpetgeo.2021.105383
ER  - 
@article{
author = "Gajica, Gordana and Šajnović, Aleksandra and Stojanović, Ksenija A. and Schwarzbauer, Jan and Kostić, Aleksandar and Jovančićević, Branimir",
year = "2022",
abstract = "The molecular and isotopic composition of biomarkers in initial bitumen isolated from immature (0.41% Rr) oil shale samples (Aleksinac deposit) and liquid products obtained by pyrolysis in open (OS) and closed (CS) systems are studied. The influence of pyrolysis type and variations of kerogen type on biomarkers composition and their isotopic signatures in liquid products is determined. The applicability of pyrolysis type, numerous biomarkers and carbon isotopic compositions (δ13C) of n-alkanes in liquid pyrolysates is established. Pyrolysis experiments were performed on two selected samples that showed high content of total organic carbon and hydrocarbon generation potential, but also certain variations in sources/depositional environment of organic matter (type I and mixed type I/II kerogen) within previous research of the oil shales sample set. The biomarker signatures were evaluated using gas chromatography-mass spectrometry (GC-MS) and δ13C of individual n-alkanes in bitumen and liquid pyrolysates. The molecular composition of liquid pyrolysates from the OS is very similar to those in initial bitumen, independently on kerogen type, confirming algal origin of organic matter (OM) deposited in lacustrine environment, even more apparently than results of initial bitumen. Therefore, OS can be useful for assessment of source and depositional environment of OM. Pyrolysis in the CS caused more intense thermal alterations, therefore the source fingerprints sometimes notably disappear. The liquid pyrolysates from the CS have the distributions of biomarkers similar to those in crude oils. The biomarker maturity parameters showed slightly higher values in the CS pyrolysate of mixed type I/II kerogen in relation to type I kerogen. δ13C of n-alkanes in liquid pyrolysates from the OS are isotopically lighter in comparison to bitumen, independently on kerogen type. Oppositely, in liquid pyrolysates from the CS, they become heavier than in bitumen, indicating the thermal influence on δ13C signatures, with more pronounced difference for type I kerogen.",
publisher = "Elsevier",
journal = "Marine and Petroleum Geology",
title = "A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems)",
volume = "136",
pages = "105383",
doi = "10.1016/j.marpetgeo.2021.105383"
}
Gajica, G., Šajnović, A., Stojanović, K. A., Schwarzbauer, J., Kostić, A.,& Jovančićević, B.. (2022). A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems). in Marine and Petroleum Geology
Elsevier., 136, 105383.
https://doi.org/10.1016/j.marpetgeo.2021.105383
Gajica G, Šajnović A, Stojanović KA, Schwarzbauer J, Kostić A, Jovančićević B. A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems). in Marine and Petroleum Geology. 2022;136:105383.
doi:10.1016/j.marpetgeo.2021.105383 .
Gajica, Gordana, Šajnović, Aleksandra, Stojanović, Ksenija A., Schwarzbauer, Jan, Kostić, Aleksandar, Jovančićević, Branimir, "A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems)" in Marine and Petroleum Geology, 136 (2022):105383,
https://doi.org/10.1016/j.marpetgeo.2021.105383 . .
1
1

A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems)

Gajica, Gordana; Šajnović, Aleksandra; Stojanović, Ksenija A.; Schwarzbauer, Jan; Kostić, Aleksandar; Jovančićević, Branimir

(Elsevier, 2022)

TY  - JOUR
AU  - Gajica, Gordana
AU  - Šajnović, Aleksandra
AU  - Stojanović, Ksenija A.
AU  - Schwarzbauer, Jan
AU  - Kostić, Aleksandar
AU  - Jovančićević, Branimir
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4846
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4847
AB  - The molecular and isotopic composition of biomarkers in initial bitumen isolated from immature (0.41% Rr) oil shale samples (Aleksinac deposit) and liquid products obtained by pyrolysis in open (OS) and closed (CS) systems are studied. The influence of pyrolysis type and variations of kerogen type on biomarkers composition and their isotopic signatures in liquid products is determined. The applicability of pyrolysis type, numerous biomarkers and carbon isotopic compositions (δ13C) of n-alkanes in liquid pyrolysates is established. Pyrolysis experiments were performed on two selected samples that showed high content of total organic carbon and hydrocarbon generation potential, but also certain variations in sources/depositional environment of organic matter (type I and mixed type I/II kerogen) within previous research of the oil shales sample set. The biomarker signatures were evaluated using gas chromatography-mass spectrometry (GC-MS) and δ13C of individual n-alkanes in bitumen and liquid pyrolysates. The molecular composition of liquid pyrolysates from the OS is very similar to those in initial bitumen, independently on kerogen type, confirming algal origin of organic matter (OM) deposited in lacustrine environment, even more apparently than results of initial bitumen. Therefore, OS can be useful for assessment of source and depositional environment of OM. Pyrolysis in the CS caused more intense thermal alterations, therefore the source fingerprints sometimes notably disappear. The liquid pyrolysates from the CS have the distributions of biomarkers similar to those in crude oils. The biomarker maturity parameters showed slightly higher values in the CS pyrolysate of mixed type I/II kerogen in relation to type I kerogen. δ13C of n-alkanes in liquid pyrolysates from the OS are isotopically lighter in comparison to bitumen, independently on kerogen type. Oppositely, in liquid pyrolysates from the CS, they become heavier than in bitumen, indicating the thermal influence on δ13C signatures, with more pronounced difference for type I kerogen.
PB  - Elsevier
T2  - Marine and Petroleum Geology
T1  - A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems)
VL  - 136
SP  - 105383
DO  - 10.1016/j.marpetgeo.2021.105383
ER  - 
@article{
author = "Gajica, Gordana and Šajnović, Aleksandra and Stojanović, Ksenija A. and Schwarzbauer, Jan and Kostić, Aleksandar and Jovančićević, Branimir",
year = "2022",
abstract = "The molecular and isotopic composition of biomarkers in initial bitumen isolated from immature (0.41% Rr) oil shale samples (Aleksinac deposit) and liquid products obtained by pyrolysis in open (OS) and closed (CS) systems are studied. The influence of pyrolysis type and variations of kerogen type on biomarkers composition and their isotopic signatures in liquid products is determined. The applicability of pyrolysis type, numerous biomarkers and carbon isotopic compositions (δ13C) of n-alkanes in liquid pyrolysates is established. Pyrolysis experiments were performed on two selected samples that showed high content of total organic carbon and hydrocarbon generation potential, but also certain variations in sources/depositional environment of organic matter (type I and mixed type I/II kerogen) within previous research of the oil shales sample set. The biomarker signatures were evaluated using gas chromatography-mass spectrometry (GC-MS) and δ13C of individual n-alkanes in bitumen and liquid pyrolysates. The molecular composition of liquid pyrolysates from the OS is very similar to those in initial bitumen, independently on kerogen type, confirming algal origin of organic matter (OM) deposited in lacustrine environment, even more apparently than results of initial bitumen. Therefore, OS can be useful for assessment of source and depositional environment of OM. Pyrolysis in the CS caused more intense thermal alterations, therefore the source fingerprints sometimes notably disappear. The liquid pyrolysates from the CS have the distributions of biomarkers similar to those in crude oils. The biomarker maturity parameters showed slightly higher values in the CS pyrolysate of mixed type I/II kerogen in relation to type I kerogen. δ13C of n-alkanes in liquid pyrolysates from the OS are isotopically lighter in comparison to bitumen, independently on kerogen type. Oppositely, in liquid pyrolysates from the CS, they become heavier than in bitumen, indicating the thermal influence on δ13C signatures, with more pronounced difference for type I kerogen.",
publisher = "Elsevier",
journal = "Marine and Petroleum Geology",
title = "A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems)",
volume = "136",
pages = "105383",
doi = "10.1016/j.marpetgeo.2021.105383"
}
Gajica, G., Šajnović, A., Stojanović, K. A., Schwarzbauer, J., Kostić, A.,& Jovančićević, B.. (2022). A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems). in Marine and Petroleum Geology
Elsevier., 136, 105383.
https://doi.org/10.1016/j.marpetgeo.2021.105383
Gajica G, Šajnović A, Stojanović KA, Schwarzbauer J, Kostić A, Jovančićević B. A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems). in Marine and Petroleum Geology. 2022;136:105383.
doi:10.1016/j.marpetgeo.2021.105383 .
Gajica, Gordana, Šajnović, Aleksandra, Stojanović, Ksenija A., Schwarzbauer, Jan, Kostić, Aleksandar, Jovančićević, Branimir, "A comparative study of the molecular and isotopic composition of biomarkers in immature oil shale (Aleksinac deposit, Serbia) and its liquid pyrolysis products (open and closed systems)" in Marine and Petroleum Geology, 136 (2022):105383,
https://doi.org/10.1016/j.marpetgeo.2021.105383 . .
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