TY  - JOUR
AU  - Binh, Dang Ho
AU  - Milovanović, Milan R.
AU  - Puertes-Mico, Julia
AU  - Hamdaoui, Mustapha
AU  - Zarić, Snežana D.
AU  - Đukić, Jean-Pierre
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/2571
AB  - The computation of metal-silyl interaction energies indicates the existence of situations in which the silyl group behaves as a Z-type ligand according to the Green method of covalent-bond classification. There is a scale of relative intrinsic silylicity , defined as the ratio of the intrinsic silyl-to-triflate interaction energy of a silyltriflate as a reference compound relative to the silyl-to-metal interaction of given complex, that can reveal in a straightforward manner the propensity of SiR3 groups to behave chemically as metal-bound silylium ions, namely, [SiR3](+). Emblematic cases, either taken from the Cambridge Structural Database (CSD) or constructed for the purpose of this study, were also investigated from the viewpoints of extended transition-state natural orbitals for chemical valence (ETS-NOCV) and quantum theory of atoms in molecules (QTAIM) analyses. It is shown in the case of POBMUPwhich is the iridium 1,3-bis[(di-tert-butylphosphino)oxy]benzene (POCOP) complex isolated by Brookhart etal.how slight variations of molecular charge and structure can drastically affect the relative intrinsic silylicity of the SiEt3 group that is weakly bonded to the hydrido-iridium motif.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry. A European Journal
T1  - Is the R3Si Moiety in Metal-Silyl Complexes a Z ligand? AnAnswer from the Interaction Energy
VL  - 23
IS  - 67
SP  - 17058
EP  - 17069
DO  - 10.1002/chem.201703373
ER  - 

@article{
author = "Binh, Dang Ho and Milovanović, Milan R. and Puertes-Mico, Julia and Hamdaoui, Mustapha and Zarić, Snežana D. and Đukić, Jean-Pierre",
year = "2017",
abstract = "The computation of metal-silyl interaction energies indicates the existence of situations in which the silyl group behaves as a Z-type ligand according to the Green method of covalent-bond classification. There is a scale of relative intrinsic silylicity , defined as the ratio of the intrinsic silyl-to-triflate interaction energy of a silyltriflate as a reference compound relative to the silyl-to-metal interaction of given complex, that can reveal in a straightforward manner the propensity of SiR3 groups to behave chemically as metal-bound silylium ions, namely, [SiR3](+). Emblematic cases, either taken from the Cambridge Structural Database (CSD) or constructed for the purpose of this study, were also investigated from the viewpoints of extended transition-state natural orbitals for chemical valence (ETS-NOCV) and quantum theory of atoms in molecules (QTAIM) analyses. It is shown in the case of POBMUPwhich is the iridium 1,3-bis[(di-tert-butylphosphino)oxy]benzene (POCOP) complex isolated by Brookhart etal.how slight variations of molecular charge and structure can drastically affect the relative intrinsic silylicity of the SiEt3 group that is weakly bonded to the hydrido-iridium motif.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry. A European Journal",
title = "Is the R3Si Moiety in Metal-Silyl Complexes a Z ligand? AnAnswer from the Interaction Energy",
volume = "23",
number = "67",
pages = "17058-17069",
doi = "10.1002/chem.201703373"
}

Binh, D. H., Milovanović, M. R., Puertes-Mico, J., Hamdaoui, M., Zarić, S. D.,& Đukić, J.. (2017). Is the R3Si Moiety in Metal-Silyl Complexes a Z ligand? AnAnswer from the Interaction Energy. in Chemistry. A European Journal
Wiley-V C H Verlag Gmbh, Weinheim., 23(67), 17058-17069.
https://doi.org/10.1002/chem.201703373

Binh DH, Milovanović MR, Puertes-Mico J, Hamdaoui M, Zarić SD, Đukić J. Is the R3Si Moiety in Metal-Silyl Complexes a Z ligand? AnAnswer from the Interaction Energy. in Chemistry. A European Journal. 2017;23(67):17058-17069.
doi:10.1002/chem.201703373 .

Binh, Dang Ho, Milovanović, Milan R., Puertes-Mico, Julia, Hamdaoui, Mustapha, Zarić, Snežana D., Đukić, Jean-Pierre, "Is the R3Si Moiety in Metal-Silyl Complexes a Z ligand? AnAnswer from the Interaction Energy" in Chemistry. A European Journal, 23, no. 67 (2017):17058-17069,
https://doi.org/10.1002/chem.201703373 . .

TY  - JOUR
AU  - Binh, Dang Ho
AU  - Milovanović, Milan R.
AU  - Puertes-Mico, Julia
AU  - Hamdaoui, Mustapha
AU  - Zarić, Snežana D.
AU  - Đukić, Jean-Pierre
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3054
AB  - The computation of metal-silyl interaction energies indicates the existence of situations in which the silyl group behaves as a Z-type ligand according to the Green method of covalent-bond classification. There is a scale of relative intrinsic silylicity , defined as the ratio of the intrinsic silyl-to-triflate interaction energy of a silyltriflate as a reference compound relative to the silyl-to-metal interaction of given complex, that can reveal in a straightforward manner the propensity of SiR3 groups to behave chemically as metal-bound silylium ions, namely, [SiR3](+). Emblematic cases, either taken from the Cambridge Structural Database (CSD) or constructed for the purpose of this study, were also investigated from the viewpoints of extended transition-state natural orbitals for chemical valence (ETS-NOCV) and quantum theory of atoms in molecules (QTAIM) analyses. It is shown in the case of POBMUPwhich is the iridium 1,3-bis[(di-tert-butylphosphino)oxy]benzene (POCOP) complex isolated by Brookhart etal.how slight variations of molecular charge and structure can drastically affect the relative intrinsic silylicity of the SiEt3 group that is weakly bonded to the hydrido-iridium motif.
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry - A European Journal
T1  - Is the R 3 Si Moiety in Metal–Silyl Complexes a Z ligand? An Answer from the Interaction Energy
VL  - 23
IS  - 67
SP  - 17058
EP  - 17069
DO  - 10.1002/chem.201703373
ER  - 

@article{
author = "Binh, Dang Ho and Milovanović, Milan R. and Puertes-Mico, Julia and Hamdaoui, Mustapha and Zarić, Snežana D. and Đukić, Jean-Pierre",
year = "2017",
abstract = "The computation of metal-silyl interaction energies indicates the existence of situations in which the silyl group behaves as a Z-type ligand according to the Green method of covalent-bond classification. There is a scale of relative intrinsic silylicity , defined as the ratio of the intrinsic silyl-to-triflate interaction energy of a silyltriflate as a reference compound relative to the silyl-to-metal interaction of given complex, that can reveal in a straightforward manner the propensity of SiR3 groups to behave chemically as metal-bound silylium ions, namely, [SiR3](+). Emblematic cases, either taken from the Cambridge Structural Database (CSD) or constructed for the purpose of this study, were also investigated from the viewpoints of extended transition-state natural orbitals for chemical valence (ETS-NOCV) and quantum theory of atoms in molecules (QTAIM) analyses. It is shown in the case of POBMUPwhich is the iridium 1,3-bis[(di-tert-butylphosphino)oxy]benzene (POCOP) complex isolated by Brookhart etal.how slight variations of molecular charge and structure can drastically affect the relative intrinsic silylicity of the SiEt3 group that is weakly bonded to the hydrido-iridium motif.",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry - A European Journal",
title = "Is the R 3 Si Moiety in Metal–Silyl Complexes a Z ligand? An Answer from the Interaction Energy",
volume = "23",
number = "67",
pages = "17058-17069",
doi = "10.1002/chem.201703373"
}

Binh, D. H., Milovanović, M. R., Puertes-Mico, J., Hamdaoui, M., Zarić, S. D.,& Đukić, J.. (2017). Is the R 3 Si Moiety in Metal–Silyl Complexes a Z ligand? An Answer from the Interaction Energy. in Chemistry - A European Journal
Wiley-V C H Verlag Gmbh, Weinheim., 23(67), 17058-17069.
https://doi.org/10.1002/chem.201703373

Binh DH, Milovanović MR, Puertes-Mico J, Hamdaoui M, Zarić SD, Đukić J. Is the R 3 Si Moiety in Metal–Silyl Complexes a Z ligand? An Answer from the Interaction Energy. in Chemistry - A European Journal. 2017;23(67):17058-17069.
doi:10.1002/chem.201703373 .

Binh, Dang Ho, Milovanović, Milan R., Puertes-Mico, Julia, Hamdaoui, Mustapha, Zarić, Snežana D., Đukić, Jean-Pierre, "Is the R 3 Si Moiety in Metal–Silyl Complexes a Z ligand? An Answer from the Interaction Energy" in Chemistry - A European Journal, 23, no. 67 (2017):17058-17069,
https://doi.org/10.1002/chem.201703373 . .

TY  - DATA
AU  - Binh, Dang Ho
AU  - Milovanović, Milan R.
AU  - Puertes-Mico, Julia
AU  - Hamdaoui, Mustapha
AU  - Zarić, Snežana D.
AU  - Đukić, Jean-Pierre
PY  - 2017
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3056
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Chemistry - A European Journal
T1  - Supplementary data for article: Binh, D. H.; Milovanović, M.; Puertes-Mico, J.; Hamdaoui, M.; Zarić, S. D.; Djukic, J.-P. Is the R 3 Si Moiety in Metal–Silyl Complexes a Z Ligand? An Answer from the Interaction Energy. Chemistry - A European Journal 2017, 23 (67), 17058–17069. https://doi.org/10.1002/chem.201703373
UR  - https://hdl.handle.net/21.15107/rcub_cherry_3056
ER  - 

@misc{
author = "Binh, Dang Ho and Milovanović, Milan R. and Puertes-Mico, Julia and Hamdaoui, Mustapha and Zarić, Snežana D. and Đukić, Jean-Pierre",
year = "2017",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Chemistry - A European Journal",
title = "Supplementary data for article: Binh, D. H.; Milovanović, M.; Puertes-Mico, J.; Hamdaoui, M.; Zarić, S. D.; Djukic, J.-P. Is the R 3 Si Moiety in Metal–Silyl Complexes a Z Ligand? An Answer from the Interaction Energy. Chemistry - A European Journal 2017, 23 (67), 17058–17069. https://doi.org/10.1002/chem.201703373",
url = "https://hdl.handle.net/21.15107/rcub_cherry_3056"
}

Binh, D. H., Milovanović, M. R., Puertes-Mico, J., Hamdaoui, M., Zarić, S. D.,& Đukić, J.. (2017). Supplementary data for article: Binh, D. H.; Milovanović, M.; Puertes-Mico, J.; Hamdaoui, M.; Zarić, S. D.; Djukic, J.-P. Is the R 3 Si Moiety in Metal–Silyl Complexes a Z Ligand? An Answer from the Interaction Energy. Chemistry - A European Journal 2017, 23 (67), 17058–17069. https://doi.org/10.1002/chem.201703373. in Chemistry - A European Journal
Wiley-V C H Verlag Gmbh, Weinheim..
https://hdl.handle.net/21.15107/rcub_cherry_3056

Binh DH, Milovanović MR, Puertes-Mico J, Hamdaoui M, Zarić SD, Đukić J. Supplementary data for article: Binh, D. H.; Milovanović, M.; Puertes-Mico, J.; Hamdaoui, M.; Zarić, S. D.; Djukic, J.-P. Is the R 3 Si Moiety in Metal–Silyl Complexes a Z Ligand? An Answer from the Interaction Energy. Chemistry - A European Journal 2017, 23 (67), 17058–17069. https://doi.org/10.1002/chem.201703373. in Chemistry - A European Journal. 2017;.
https://hdl.handle.net/21.15107/rcub_cherry_3056 .

Binh, Dang Ho, Milovanović, Milan R., Puertes-Mico, Julia, Hamdaoui, Mustapha, Zarić, Snežana D., Đukić, Jean-Pierre, "Supplementary data for article: Binh, D. H.; Milovanović, M.; Puertes-Mico, J.; Hamdaoui, M.; Zarić, S. D.; Djukic, J.-P. Is the R 3 Si Moiety in Metal–Silyl Complexes a Z Ligand? An Answer from the Interaction Energy. Chemistry - A European Journal 2017, 23 (67), 17058–17069. https://doi.org/10.1002/chem.201703373" in Chemistry - A European Journal (2017),
https://hdl.handle.net/21.15107/rcub_cherry_3056 .

TY  - JOUR
AU  - Smiljanić, Katarina
AU  - Obradović, Milan
AU  - Jovanovic, Aleksandra
AU  - Popović-Đorđević, Jelena
AU  - Dobutović, Branislava
AU  - Jevremovic, Danimir
AU  - Marche, Pierre
AU  - Isenovic, Esma R.
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1853
AB  - In this study, the role of epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK1/2), heparin-binding EGF-like growth factor (HB-EGF), general metalloproteinases, matrix metalloproteinases-2 (MMP-2) in mediating the mitogenic action of thrombin in rat vascular smooth muscle cells (VSMC) was investigated. The incubation of rat VSMC with thrombin (1 U/ml) for 5 min resulted in significant (p  lt  0.001) increase of ERK1/2 phosphorylation by 8.7 +/- A 0.9-fold, EGFR phosphorylation by 8.5 +/- A 1.3-fold (p  lt  0.001) and DNA synthesis by 3.6 +/- A 0.4-fold (p  lt  0.001). Separate 30-min pretreatments with EGFR tyrosine kinase irreversible inhibitor, 10 A mu M PD169540 (PD), and 20 A mu M anti-HB-EGF antibody significantly reduced thrombin-stimulated EGFR and ERK1/2 phosphorylation by 81, 72 % and by 48 and 61 %, respectively. Furthermore, the same pretreatments with PD or anti-HB-EGF antibody reduced thrombin-induced VSMC proliferation by 44 and 45 %, respectively. In addition, 30-min pretreatments with 10 A mu M specific MMP-2 inhibitor significantly reduced thrombin-stimulated phosphorylation of both EGFR and ERK1/2 by 25 %. Moreover, the same pretreatment with MMP-2 inhibitor reduced thrombin-induced VSMC proliferation by 45 %. These results show that the thrombin-induced DNA synthesis correlates with the level of ERK1/2 activation rather than EGFR activation. These results further suggest that thrombin acts through EGFR and ERK 1/2 signaling pathways involving MMP-2 to upregulate proliferation of VSMC.
PB  - Springer, Dordrecht
T2  - Molecular and Cellular Biochemistry
T1  - Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway: involvement of MMP-2
VL  - 396
IS  - 1-2
SP  - 147
EP  - 160
DO  - 10.1007/s11010-014-2151-y
ER  - 

@article{
author = "Smiljanić, Katarina and Obradović, Milan and Jovanovic, Aleksandra and Popović-Đorđević, Jelena and Dobutović, Branislava and Jevremovic, Danimir and Marche, Pierre and Isenovic, Esma R.",
year = "2014",
abstract = "In this study, the role of epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK1/2), heparin-binding EGF-like growth factor (HB-EGF), general metalloproteinases, matrix metalloproteinases-2 (MMP-2) in mediating the mitogenic action of thrombin in rat vascular smooth muscle cells (VSMC) was investigated. The incubation of rat VSMC with thrombin (1 U/ml) for 5 min resulted in significant (p  lt  0.001) increase of ERK1/2 phosphorylation by 8.7 +/- A 0.9-fold, EGFR phosphorylation by 8.5 +/- A 1.3-fold (p  lt  0.001) and DNA synthesis by 3.6 +/- A 0.4-fold (p  lt  0.001). Separate 30-min pretreatments with EGFR tyrosine kinase irreversible inhibitor, 10 A mu M PD169540 (PD), and 20 A mu M anti-HB-EGF antibody significantly reduced thrombin-stimulated EGFR and ERK1/2 phosphorylation by 81, 72 % and by 48 and 61 %, respectively. Furthermore, the same pretreatments with PD or anti-HB-EGF antibody reduced thrombin-induced VSMC proliferation by 44 and 45 %, respectively. In addition, 30-min pretreatments with 10 A mu M specific MMP-2 inhibitor significantly reduced thrombin-stimulated phosphorylation of both EGFR and ERK1/2 by 25 %. Moreover, the same pretreatment with MMP-2 inhibitor reduced thrombin-induced VSMC proliferation by 45 %. These results show that the thrombin-induced DNA synthesis correlates with the level of ERK1/2 activation rather than EGFR activation. These results further suggest that thrombin acts through EGFR and ERK 1/2 signaling pathways involving MMP-2 to upregulate proliferation of VSMC.",
publisher = "Springer, Dordrecht",
journal = "Molecular and Cellular Biochemistry",
title = "Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway: involvement of MMP-2",
volume = "396",
number = "1-2",
pages = "147-160",
doi = "10.1007/s11010-014-2151-y"
}

Smiljanić, K., Obradović, M., Jovanovic, A., Popović-Đorđević, J., Dobutović, B., Jevremovic, D., Marche, P.,& Isenovic, E. R.. (2014). Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway: involvement of MMP-2. in Molecular and Cellular Biochemistry
Springer, Dordrecht., 396(1-2), 147-160.
https://doi.org/10.1007/s11010-014-2151-y

Smiljanić K, Obradović M, Jovanovic A, Popović-Đorđević J, Dobutović B, Jevremovic D, Marche P, Isenovic ER. Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway: involvement of MMP-2. in Molecular and Cellular Biochemistry. 2014;396(1-2):147-160.
doi:10.1007/s11010-014-2151-y .

Smiljanić, Katarina, Obradović, Milan, Jovanovic, Aleksandra, Popović-Đorđević, Jelena, Dobutović, Branislava, Jevremovic, Danimir, Marche, Pierre, Isenovic, Esma R., "Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway: involvement of MMP-2" in Molecular and Cellular Biochemistry, 396, no. 1-2 (2014):147-160,
https://doi.org/10.1007/s11010-014-2151-y . .

TY  - JOUR
AU  - Petrović, Predrag
AU  - Grimme, Stefan
AU  - Zarić, Snežana D.
AU  - Pfeffer, Michel
AU  - Đukić, Jean-Pierre
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1806
AB  - Self-aggregation in water of anti-cancer agents such as oxaliplatin (1) or its palladium-containing parent (2) is suspected to be the main reason for the exceptional resistance of concentrated infusions of these complexes to hydrolysis; this hypothesis, i.e. the self-association of metal chelates, was investigated in a systematic manner by experimental and theoretical means. H-1 diffusion-ordered NMR spectroscopy (DOSY NMR) and UV-visible absorption titration were inconclusive as to the formation of a dimer of 1 in water or DMSO. Further isothermal titration calorimetry (ITC) methods allowed the accurate determination of the enthalpy of formation of only the homodimer [2](2) and putative heterodimer [1.2] together with an estimation of the formation constants, which indicate that dimer formation is not a spontaneous process in solution, whereas electrospray ESI mass spectroscopy tends to suggest the contrary in the gas phase. A dispersion-corrected DFT method, i. e. DFT-D (BLYP-D3), was used to model the aggregation in solution (COSMO) and to investigate the assisting role of London force in the cohesion of bimolecular aggregates. The concordance of experimental and theoretical thermodynamic parameters was judged reasonably even though the treatment of solvation by conventional continuum models does not account for specific interactions of the solute with molecules of solvent; nonetheless these results outline the importance of dispersion, a.k.a. London force. The role of the latter was further stressed by computing the affinities of 1 and 2 for the lipophilic cavity of cucurbit[7]uril in modeled water (COSMO-RS), which were preliminarily determined experimentally by ITC methods using pure water as solvent. From our investigations carried out in pure water the connection between the notorious chemical stability of "concentrated'' infusions of 1 in aqueous media and the formation of oligomers remains unsettled.
PB  - Royal Soc Chemistry, Cambridge
T2  - Physical Chemistry Chemical Physics
T1  - Experimental and theoretical investigations of the self-association of oxaliplatin
VL  - 16
IS  - 28
SP  - 14688
EP  - 14698
DO  - 10.1039/c4cp01500b
ER  - 

@article{
author = "Petrović, Predrag and Grimme, Stefan and Zarić, Snežana D. and Pfeffer, Michel and Đukić, Jean-Pierre",
year = "2014",
abstract = "Self-aggregation in water of anti-cancer agents such as oxaliplatin (1) or its palladium-containing parent (2) is suspected to be the main reason for the exceptional resistance of concentrated infusions of these complexes to hydrolysis; this hypothesis, i.e. the self-association of metal chelates, was investigated in a systematic manner by experimental and theoretical means. H-1 diffusion-ordered NMR spectroscopy (DOSY NMR) and UV-visible absorption titration were inconclusive as to the formation of a dimer of 1 in water or DMSO. Further isothermal titration calorimetry (ITC) methods allowed the accurate determination of the enthalpy of formation of only the homodimer [2](2) and putative heterodimer [1.2] together with an estimation of the formation constants, which indicate that dimer formation is not a spontaneous process in solution, whereas electrospray ESI mass spectroscopy tends to suggest the contrary in the gas phase. A dispersion-corrected DFT method, i. e. DFT-D (BLYP-D3), was used to model the aggregation in solution (COSMO) and to investigate the assisting role of London force in the cohesion of bimolecular aggregates. The concordance of experimental and theoretical thermodynamic parameters was judged reasonably even though the treatment of solvation by conventional continuum models does not account for specific interactions of the solute with molecules of solvent; nonetheless these results outline the importance of dispersion, a.k.a. London force. The role of the latter was further stressed by computing the affinities of 1 and 2 for the lipophilic cavity of cucurbit[7]uril in modeled water (COSMO-RS), which were preliminarily determined experimentally by ITC methods using pure water as solvent. From our investigations carried out in pure water the connection between the notorious chemical stability of "concentrated'' infusions of 1 in aqueous media and the formation of oligomers remains unsettled.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Physical Chemistry Chemical Physics",
title = "Experimental and theoretical investigations of the self-association of oxaliplatin",
volume = "16",
number = "28",
pages = "14688-14698",
doi = "10.1039/c4cp01500b"
}

Petrović, P., Grimme, S., Zarić, S. D., Pfeffer, M.,& Đukić, J.. (2014). Experimental and theoretical investigations of the self-association of oxaliplatin. in Physical Chemistry Chemical Physics
Royal Soc Chemistry, Cambridge., 16(28), 14688-14698.
https://doi.org/10.1039/c4cp01500b

Petrović P, Grimme S, Zarić SD, Pfeffer M, Đukić J. Experimental and theoretical investigations of the self-association of oxaliplatin. in Physical Chemistry Chemical Physics. 2014;16(28):14688-14698.
doi:10.1039/c4cp01500b .

Petrović, Predrag, Grimme, Stefan, Zarić, Snežana D., Pfeffer, Michel, Đukić, Jean-Pierre, "Experimental and theoretical investigations of the self-association of oxaliplatin" in Physical Chemistry Chemical Physics, 16, no. 28 (2014):14688-14698,
https://doi.org/10.1039/c4cp01500b . .

TY  - JOUR
AU  - Bouffier, Laurent
AU  - Zigah, Dodzi
AU  - Adam, Catherine
AU  - Sentić, Milica
AU  - Fattah, Zahra
AU  - Manojlović, Dragan D.
AU  - Kuhn, Alexander
AU  - Šojić, Nešo
PY  - 2014
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1802
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - CHEMELECTROCHEM
T1  - Lighting Up Redox Propulsion with Luminol Electrogenerated Chemiluminescence
VL  - 1
IS  - 1
SP  - 95
EP  - 98
DO  - 10.1002/celc.201300042
ER  - 

@article{
author = "Bouffier, Laurent and Zigah, Dodzi and Adam, Catherine and Sentić, Milica and Fattah, Zahra and Manojlović, Dragan D. and Kuhn, Alexander and Šojić, Nešo",
year = "2014",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "CHEMELECTROCHEM",
title = "Lighting Up Redox Propulsion with Luminol Electrogenerated Chemiluminescence",
volume = "1",
number = "1",
pages = "95-98",
doi = "10.1002/celc.201300042"
}

Bouffier, L., Zigah, D., Adam, C., Sentić, M., Fattah, Z., Manojlović, D. D., Kuhn, A.,& Šojić, N.. (2014). Lighting Up Redox Propulsion with Luminol Electrogenerated Chemiluminescence. in CHEMELECTROCHEM
Wiley-V C H Verlag Gmbh, Weinheim., 1(1), 95-98.
https://doi.org/10.1002/celc.201300042

Bouffier L, Zigah D, Adam C, Sentić M, Fattah Z, Manojlović DD, Kuhn A, Šojić N. Lighting Up Redox Propulsion with Luminol Electrogenerated Chemiluminescence. in CHEMELECTROCHEM. 2014;1(1):95-98.
doi:10.1002/celc.201300042 .

Bouffier, Laurent, Zigah, Dodzi, Adam, Catherine, Sentić, Milica, Fattah, Zahra, Manojlović, Dragan D., Kuhn, Alexander, Šojić, Nešo, "Lighting Up Redox Propulsion with Luminol Electrogenerated Chemiluminescence" in CHEMELECTROCHEM, 1, no. 1 (2014):95-98,
https://doi.org/10.1002/celc.201300042 . .

TY  - JOUR
AU  - Sentić, Milica
AU  - Loget, Gabriel
AU  - Manojlović, Dragan D.
AU  - Kuhn, Alexander
AU  - Šojić, Nešo
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1549
PB  - Wiley-V C H Verlag Gmbh, Weinheim
T2  - Angewandte Chemie (International Edition)
T1  - Light-Emitting Electrochemical "Swimmers"
VL  - 51
IS  - 45
SP  - 11284
EP  - 11288
DO  - 10.1002/anie.201206227
ER  - 

@article{
author = "Sentić, Milica and Loget, Gabriel and Manojlović, Dragan D. and Kuhn, Alexander and Šojić, Nešo",
year = "2012",
publisher = "Wiley-V C H Verlag Gmbh, Weinheim",
journal = "Angewandte Chemie (International Edition)",
title = "Light-Emitting Electrochemical "Swimmers"",
volume = "51",
number = "45",
pages = "11284-11288",
doi = "10.1002/anie.201206227"
}

Sentić, M., Loget, G., Manojlović, D. D., Kuhn, A.,& Šojić, N.. (2012). Light-Emitting Electrochemical "Swimmers". in Angewandte Chemie (International Edition)
Wiley-V C H Verlag Gmbh, Weinheim., 51(45), 11284-11288.
https://doi.org/10.1002/anie.201206227

Sentić M, Loget G, Manojlović DD, Kuhn A, Šojić N. Light-Emitting Electrochemical "Swimmers". in Angewandte Chemie (International Edition). 2012;51(45):11284-11288.
doi:10.1002/anie.201206227 .

Sentić, Milica, Loget, Gabriel, Manojlović, Dragan D., Kuhn, Alexander, Šojić, Nešo, "Light-Emitting Electrochemical "Swimmers"" in Angewandte Chemie (International Edition), 51, no. 45 (2012):11284-11288,
https://doi.org/10.1002/anie.201206227 . .

TY  - JOUR
AU  - Smiljanić, Katarina
AU  - Dobutovic, B.
AU  - Obradović, Milan
AU  - Nikolić, D.
AU  - Marche, P.
AU  - Isenovic, E. R.
PY  - 2011
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1195
AB  - Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the various vascular diseases, including atherosclerosis and hypertension. Thrombin (Thr) is involved in the abnormal proliferation of VSMCs associated with atherosclerosis and hypertension. ADAMs (A Disintegrin And Metalloproteinase) are transmembrane metalloproteinases, belonging to the adamalysins group, that are distinct from matrix metalloproteinases (MMPs) in a way as they have an extracellular disintegrin domain and cytoplasmic domain that can associate with intracellular proteins. There is limited knowledge about the presence of ADAM metalloproteinase activity in Thr-induced VSMCs proliferation. Therefore, this review examines recent findings in signaling mechanisms employed by Thr in modulating the regulation of proliferation of VSMCs with particular emphasis on involvement of ADAM 12 which has been identified as an important mediator of VSMCs hypertrophy and vascular diseases. These findings are critical for understanding the role of Thr in vascular biology and vascular diseases.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Medicinal Chemistry
T1  - Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation
VL  - 18
IS  - 22
SP  - 3382
EP  - 3386
DO  - 10.2174/092986711796504709
ER  - 

@article{
author = "Smiljanić, Katarina and Dobutovic, B. and Obradović, Milan and Nikolić, D. and Marche, P. and Isenovic, E. R.",
year = "2011",
abstract = "Cardiovascular disease is the largest single cause of mortality and its major underlying pathology is atherosclerosis. The proliferation of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of the various vascular diseases, including atherosclerosis and hypertension. Thrombin (Thr) is involved in the abnormal proliferation of VSMCs associated with atherosclerosis and hypertension. ADAMs (A Disintegrin And Metalloproteinase) are transmembrane metalloproteinases, belonging to the adamalysins group, that are distinct from matrix metalloproteinases (MMPs) in a way as they have an extracellular disintegrin domain and cytoplasmic domain that can associate with intracellular proteins. There is limited knowledge about the presence of ADAM metalloproteinase activity in Thr-induced VSMCs proliferation. Therefore, this review examines recent findings in signaling mechanisms employed by Thr in modulating the regulation of proliferation of VSMCs with particular emphasis on involvement of ADAM 12 which has been identified as an important mediator of VSMCs hypertrophy and vascular diseases. These findings are critical for understanding the role of Thr in vascular biology and vascular diseases.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Medicinal Chemistry",
title = "Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation",
volume = "18",
number = "22",
pages = "3382-3386",
doi = "10.2174/092986711796504709"
}

Smiljanić, K., Dobutovic, B., Obradović, M., Nikolić, D., Marche, P.,& Isenovic, E. R.. (2011). Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation. in Current Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 18(22), 3382-3386.
https://doi.org/10.2174/092986711796504709

Smiljanić K, Dobutovic B, Obradović M, Nikolić D, Marche P, Isenovic ER. Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation. in Current Medicinal Chemistry. 2011;18(22):3382-3386.
doi:10.2174/092986711796504709 .

Smiljanić, Katarina, Dobutovic, B., Obradović, Milan, Nikolić, D., Marche, P., Isenovic, E. R., "Involvement of the ADAM 12 in Thrombin-Induced Rat's VSMCs Proliferation" in Current Medicinal Chemistry, 18, no. 22 (2011):3382-3386,
https://doi.org/10.2174/092986711796504709 . .

TY  - JOUR
AU  - Isenovic, Esma R.
AU  - Fretaud, Maxence
AU  - Dobutović, Branislava
AU  - Sudar, Emina
AU  - Smiljanić, Katarina
AU  - Zarić, Božidarka L.
AU  - Trpkovic, Andreja
AU  - Marche, Pierre
PY  - 2009
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/612
AB  - Insulin (INS) via INS receptor acts as a mitogen in vascular smooth muscle cells (VSMCs) through stimulation of multiple signaling mechanisms, including p42/44 mitogen-activated protein kinase (ERK1/2) and phosphatidyl inositol-3 kinase (PI3K). In addition, cytosolic phospholipase 2 (cPLA(2)) is linked to VSMCs proliferation. However, the upstream mechanisms responsible for activation of cPLA(2) are not well defined. Therefore, this investigation used primary cultured rat VSMCs to examine the role of PI3K and ERK1/2 in the INS-dependent phosphorylation of cPLA(2) and proliferation induced by INS. Exposure of VSMCs to INS (100 nM) for 10 min increased the phosphorylation of cPLA(2) by 1.5-fold (p  lt  0.01), which was blocked by the cPLA(2) inhibitor MAFP (10 mu M; 15 min). Similarly, the PI3K inhibitor LY294002 (10 mu M; 15 min) and ERK1/2 inhibitor PD98059 (20 mu M; 15 min) abolished the INS-mediated increase in cPLA(2) phosphorylation by 59% (p  lt  0.001), and by 75% (p  lt  0.001), respectively. Further, inhibition of cPLA2 with cPLA2 inhibitor MAFP abolished the INS-stimulated ERK1/2 phosphorylation by 65% (p  lt  0.01). Incubation of rat VSMCs with INS resulted in an increase of VSMCs proliferation by 85% (p  lt  0.001). The effect of INS on VSMCs proliferation was significantly (p  lt  0.01) reduced by pretreatment with MAFP. Thus, we hypothesized that INS stimulates VSMCs proliferation via a mechanism involving the PI3K-dependent activation of cPLA(2) and release of arachidonic acid (AA), which activates ERK1/2 and further amplifies cPLA(2) activity. (C) 2009 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
PB  - Academic Press Ltd- Elsevier Science Ltd, London
T2  - Cell Biology International
T1  - A novel hypothesis regarding the possible involvement of cytosolic phospholipase 2 in insulin-stimulated proliferation of vascular smooth muscle cells
VL  - 33
IS  - 3
SP  - 386
EP  - 392
DO  - 10.1016/j.cellbi.2009.01.010
ER  - 

@article{
author = "Isenovic, Esma R. and Fretaud, Maxence and Dobutović, Branislava and Sudar, Emina and Smiljanić, Katarina and Zarić, Božidarka L. and Trpkovic, Andreja and Marche, Pierre",
year = "2009",
abstract = "Insulin (INS) via INS receptor acts as a mitogen in vascular smooth muscle cells (VSMCs) through stimulation of multiple signaling mechanisms, including p42/44 mitogen-activated protein kinase (ERK1/2) and phosphatidyl inositol-3 kinase (PI3K). In addition, cytosolic phospholipase 2 (cPLA(2)) is linked to VSMCs proliferation. However, the upstream mechanisms responsible for activation of cPLA(2) are not well defined. Therefore, this investigation used primary cultured rat VSMCs to examine the role of PI3K and ERK1/2 in the INS-dependent phosphorylation of cPLA(2) and proliferation induced by INS. Exposure of VSMCs to INS (100 nM) for 10 min increased the phosphorylation of cPLA(2) by 1.5-fold (p  lt  0.01), which was blocked by the cPLA(2) inhibitor MAFP (10 mu M; 15 min). Similarly, the PI3K inhibitor LY294002 (10 mu M; 15 min) and ERK1/2 inhibitor PD98059 (20 mu M; 15 min) abolished the INS-mediated increase in cPLA(2) phosphorylation by 59% (p  lt  0.001), and by 75% (p  lt  0.001), respectively. Further, inhibition of cPLA2 with cPLA2 inhibitor MAFP abolished the INS-stimulated ERK1/2 phosphorylation by 65% (p  lt  0.01). Incubation of rat VSMCs with INS resulted in an increase of VSMCs proliferation by 85% (p  lt  0.001). The effect of INS on VSMCs proliferation was significantly (p  lt  0.01) reduced by pretreatment with MAFP. Thus, we hypothesized that INS stimulates VSMCs proliferation via a mechanism involving the PI3K-dependent activation of cPLA(2) and release of arachidonic acid (AA), which activates ERK1/2 and further amplifies cPLA(2) activity. (C) 2009 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.",
publisher = "Academic Press Ltd- Elsevier Science Ltd, London",
journal = "Cell Biology International",
title = "A novel hypothesis regarding the possible involvement of cytosolic phospholipase 2 in insulin-stimulated proliferation of vascular smooth muscle cells",
volume = "33",
number = "3",
pages = "386-392",
doi = "10.1016/j.cellbi.2009.01.010"
}

Isenovic, E. R., Fretaud, M., Dobutović, B., Sudar, E., Smiljanić, K., Zarić, B. L., Trpkovic, A.,& Marche, P.. (2009). A novel hypothesis regarding the possible involvement of cytosolic phospholipase 2 in insulin-stimulated proliferation of vascular smooth muscle cells. in Cell Biology International
Academic Press Ltd- Elsevier Science Ltd, London., 33(3), 386-392.
https://doi.org/10.1016/j.cellbi.2009.01.010

Isenovic ER, Fretaud M, Dobutović B, Sudar E, Smiljanić K, Zarić BL, Trpkovic A, Marche P. A novel hypothesis regarding the possible involvement of cytosolic phospholipase 2 in insulin-stimulated proliferation of vascular smooth muscle cells. in Cell Biology International. 2009;33(3):386-392.
doi:10.1016/j.cellbi.2009.01.010 .

Isenovic, Esma R., Fretaud, Maxence, Dobutović, Branislava, Sudar, Emina, Smiljanić, Katarina, Zarić, Božidarka L., Trpkovic, Andreja, Marche, Pierre, "A novel hypothesis regarding the possible involvement of cytosolic phospholipase 2 in insulin-stimulated proliferation of vascular smooth muscle cells" in Cell Biology International, 33, no. 3 (2009):386-392,
https://doi.org/10.1016/j.cellbi.2009.01.010 . .