Beneficentia Stiftung

Link to this page

Beneficentia Stiftung

Authors

Publications

Reactions of cytotoxic metallodrugs with lysozyme in pure DMSO explored through UV-Vis absorption spectroscopy and ESI MS

Marzo, Tiziano; Savić, Aleksandar; Massai, Lara; Michelucci, Elena; Sabo, Tibor; Grgurić-Šipka, Sanja; Messori, Luigi

(Springer, Dordrecht, 2015)

TY  - JOUR
AU  - Marzo, Tiziano
AU  - Savić, Aleksandar
AU  - Massai, Lara
AU  - Michelucci, Elena
AU  - Sabo, Tibor
AU  - Grgurić-Šipka, Sanja
AU  - Messori, Luigi
PY  - 2015
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1683
AB  - The reactions of four representative metallodrugs with the model protein HEWL were investigated within a non-aqueous environment-i.e. in pure DMSO- through UV-Vis absorption spectroscopy and ESI MS analysis. Notably, formation of a variety of metallodrug-protein adducts was clearly documented. This is the first example for this kind of protein metalation reactions carried out within a pure organic solvent. It is shown that the applied solution conditions greatly affect the nature of the formed adducts, this being well accounted for by the fact that the overall protein conformation is greatly perturbed within pure DMSO; in addition, the activation profiles of the studied metallodrugs are also highly dependent on the nature of the solvent. The implications of these results are discussed.
PB  - Springer, Dordrecht
T2  - Biometals
T1  - Reactions of cytotoxic metallodrugs with lysozyme in pure DMSO explored through UV-Vis absorption spectroscopy and ESI MS
VL  - 28
IS  - 2
SP  - 425
EP  - 430
DO  - 10.1007/s10534-015-9839-7
ER  - 
@article{
author = "Marzo, Tiziano and Savić, Aleksandar and Massai, Lara and Michelucci, Elena and Sabo, Tibor and Grgurić-Šipka, Sanja and Messori, Luigi",
year = "2015",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1683",
abstract = "The reactions of four representative metallodrugs with the model protein HEWL were investigated within a non-aqueous environment-i.e. in pure DMSO- through UV-Vis absorption spectroscopy and ESI MS analysis. Notably, formation of a variety of metallodrug-protein adducts was clearly documented. This is the first example for this kind of protein metalation reactions carried out within a pure organic solvent. It is shown that the applied solution conditions greatly affect the nature of the formed adducts, this being well accounted for by the fact that the overall protein conformation is greatly perturbed within pure DMSO; in addition, the activation profiles of the studied metallodrugs are also highly dependent on the nature of the solvent. The implications of these results are discussed.",
publisher = "Springer, Dordrecht",
journal = "Biometals",
title = "Reactions of cytotoxic metallodrugs with lysozyme in pure DMSO explored through UV-Vis absorption spectroscopy and ESI MS",
volume = "28",
number = "2",
pages = "425-430",
doi = "10.1007/s10534-015-9839-7"
}
Marzo, T., Savić, A., Massai, L., Michelucci, E., Sabo, T., Grgurić-Šipka, S.,& Messori, L. (2015). Reactions of cytotoxic metallodrugs with lysozyme in pure DMSO explored through UV-Vis absorption spectroscopy and ESI MS.
Biometals
Springer, Dordrecht., 28(2), 425-430.
https://doi.org/10.1007/s10534-015-9839-7
Marzo T, Savić A, Massai L, Michelucci E, Sabo T, Grgurić-Šipka S, Messori L. Reactions of cytotoxic metallodrugs with lysozyme in pure DMSO explored through UV-Vis absorption spectroscopy and ESI MS. Biometals. 2015;28(2):425-430
Marzo Tiziano, Savić Aleksandar, Massai Lara, Michelucci Elena, Sabo Tibor, Grgurić-Šipka Sanja, Messori Luigi, "Reactions of cytotoxic metallodrugs with lysozyme in pure DMSO explored through UV-Vis absorption spectroscopy and ESI MS" Biometals, 28, no. 2 (2015):425-430,
https://doi.org/10.1007/s10534-015-9839-7 .
3
4
4