Molecular mechanisms of physiological and pharmacological control of inflammation and cancer

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Molecular mechanisms of physiological and pharmacological control of inflammation and cancer (en)
Молекуларни механизми физиолошке и фармаколошке контроле инфламације и канцера (sr)
Molekularni mehanizmi fiziološke i farmakološke kontrole inflamacije i kancera (sr_RS)
Authors

Publications

Anti-encephalitogenic effects of cucumber leaf extract

Jevtic, Bojan; Djedovic, Neda; Stanisavljevic, Suzana; Gašić, Uroš M.; Mišić, Danijela; Despotovic, Jovana; Samardžić, Jelena; Miljkovic, Djordje; Timotijević, Gordana

(Elsevier Science Bv, Amsterdam, 2017)

TY  - JOUR
AU  - Jevtic, Bojan
AU  - Djedovic, Neda
AU  - Stanisavljevic, Suzana
AU  - Gašić, Uroš M.
AU  - Mišić, Danijela
AU  - Despotovic, Jovana
AU  - Samardžić, Jelena
AU  - Miljkovic, Djordje
AU  - Timotijević, Gordana
PY  - 2017
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/2537
AB  - Cucumber (Cucumis sativus) fruit has been used in cuisine worldwide, while its leaves are rich in immunomodulatory compounds. Cucumber leaf extract (CLE) was characterized by the predominance of triterpenoids cucurbitacins and significant levels of phenolics. Effects of CLE on CD4(+) T helper (Th) cells and macrophages, as the major encephalitogenic cells in the autoimmunity of the central nervous system were investigated in our study. CLE potently inhibited production of major pathogenic Th cytokines: interferon-gamma and interleukin-17, as well as of nitric oxide and reactive oxygen species in macrophages. Antigen-presenting activity of macrophages and dendritic cells was also affected by CLE. The effects of CLE were co-incident with modulation of NFKB and p38 MAPK signaling. Concentrations of CLE used in vitro did not show toxic effects on zebrafish embryos. Moreover, CLE inhibited generation of encephalitogenic cells in vivo. These results demonstrate that CLE deserve further investigation on its anti-encephalitogenic therapeutic properties. (C) 2017 Elsevier Ltd. All rights reserved.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Functional Foods
T1  - Anti-encephalitogenic effects of cucumber leaf extract
VL  - 37
SP  - 249
EP  - 262
DO  - 10.1016/j.jff.2017.07.060
ER  - 
@article{
author = "Jevtic, Bojan and Djedovic, Neda and Stanisavljevic, Suzana and Gašić, Uroš M. and Mišić, Danijela and Despotovic, Jovana and Samardžić, Jelena and Miljkovic, Djordje and Timotijević, Gordana",
year = "2017",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/2537",
abstract = "Cucumber (Cucumis sativus) fruit has been used in cuisine worldwide, while its leaves are rich in immunomodulatory compounds. Cucumber leaf extract (CLE) was characterized by the predominance of triterpenoids cucurbitacins and significant levels of phenolics. Effects of CLE on CD4(+) T helper (Th) cells and macrophages, as the major encephalitogenic cells in the autoimmunity of the central nervous system were investigated in our study. CLE potently inhibited production of major pathogenic Th cytokines: interferon-gamma and interleukin-17, as well as of nitric oxide and reactive oxygen species in macrophages. Antigen-presenting activity of macrophages and dendritic cells was also affected by CLE. The effects of CLE were co-incident with modulation of NFKB and p38 MAPK signaling. Concentrations of CLE used in vitro did not show toxic effects on zebrafish embryos. Moreover, CLE inhibited generation of encephalitogenic cells in vivo. These results demonstrate that CLE deserve further investigation on its anti-encephalitogenic therapeutic properties. (C) 2017 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Functional Foods",
title = "Anti-encephalitogenic effects of cucumber leaf extract",
volume = "37",
pages = "249-262",
doi = "10.1016/j.jff.2017.07.060"
}
Jevtic, B., Djedovic, N., Stanisavljevic, S., Gašić, U. M., Mišić, D., Despotovic, J., Samardžić, J., Miljkovic, D.,& Timotijević, G. (2017). Anti-encephalitogenic effects of cucumber leaf extract.
Journal of Functional Foods
Elsevier Science Bv, Amsterdam., 37, 249-262.
https://doi.org/10.1016/j.jff.2017.07.060
Jevtic B, Djedovic N, Stanisavljevic S, Gašić UM, Mišić D, Despotovic J, Samardžić J, Miljkovic D, Timotijević G. Anti-encephalitogenic effects of cucumber leaf extract. Journal of Functional Foods. 2017;37:249-262
Jevtic Bojan, Djedovic Neda, Stanisavljevic Suzana, Gašić Uroš M., Mišić Danijela, Despotovic Jovana, Samardžić Jelena, Miljkovic Djordje, Timotijević Gordana, "Anti-encephalitogenic effects of cucumber leaf extract" Journal of Functional Foods, 37 (2017):249-262,
https://doi.org/10.1016/j.jff.2017.07.060 .
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Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes

Mojic, Marija; Savić, Aleksandar; Arion, Vladimir B.; Bulatović, Mirna Z.; Poljarević, Jelena; Miljkovic, Djordje; Sabo, Tibor; Mijatovic, Sanja; Maksimovic-Ivanic, Danijela; Grgurić-Šipka, Sanja

(Elsevier Science Sa, Lausanne, 2014)

TY  - JOUR
AU  - Mojic, Marija
AU  - Savić, Aleksandar
AU  - Arion, Vladimir B.
AU  - Bulatović, Mirna Z.
AU  - Poljarević, Jelena
AU  - Miljkovic, Djordje
AU  - Sabo, Tibor
AU  - Mijatovic, Sanja
AU  - Maksimovic-Ivanic, Danijela
AU  - Grgurić-Šipka, Sanja
PY  - 2014
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1450
AB  - Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl) propanoic acid as ligands were prepared from p-cymene ruthenium dichloride dimer and corresponding ester. All compounds have been characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR spectroscopy. Single crystal X-ray structure diffraction analysis of C1 shows the usual piano-stool geometry of complexes, with coordination of ester ligand via nitrogen donor atoms. Ligands exhibit moderate anticancer activity (IC50  gt  50 mu M), while the complexes were significantly more cytotoxic towards various cancer cell lines, including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0 mu M). We stress that cisplatin resistant HCT116 cell line was highly sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M versus IC50  gt  120 mu M for cisplatin). In parallel, primary fibroblasts-MRC-5 were remarkably less affected by these compounds. (C) 2013 Elsevier B. V. All rights reserved.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Organometallic Chemistry
T1  - Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes
VL  - 749
SP  - 142
EP  - 149
DO  - 10.1016/j.jorganchem.2013.08.041
ER  - 
@article{
author = "Mojic, Marija and Savić, Aleksandar and Arion, Vladimir B. and Bulatović, Mirna Z. and Poljarević, Jelena and Miljkovic, Djordje and Sabo, Tibor and Mijatovic, Sanja and Maksimovic-Ivanic, Danijela and Grgurić-Šipka, Sanja",
year = "2014",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1450",
abstract = "Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl) propanoic acid as ligands were prepared from p-cymene ruthenium dichloride dimer and corresponding ester. All compounds have been characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR spectroscopy. Single crystal X-ray structure diffraction analysis of C1 shows the usual piano-stool geometry of complexes, with coordination of ester ligand via nitrogen donor atoms. Ligands exhibit moderate anticancer activity (IC50  gt  50 mu M), while the complexes were significantly more cytotoxic towards various cancer cell lines, including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0 mu M). We stress that cisplatin resistant HCT116 cell line was highly sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M versus IC50  gt  120 mu M for cisplatin). In parallel, primary fibroblasts-MRC-5 were remarkably less affected by these compounds. (C) 2013 Elsevier B. V. All rights reserved.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Organometallic Chemistry",
title = "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes",
volume = "749",
pages = "142-149",
doi = "10.1016/j.jorganchem.2013.08.041"
}
Mojic, M., Savić, A., Arion, V. B., Bulatović, M. Z., Poljarević, J., Miljkovic, D., Sabo, T., Mijatovic, S., Maksimovic-Ivanic, D.,& Grgurić-Šipka, S. (2014). Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes.
Journal of Organometallic Chemistry
Elsevier Science Sa, Lausanne., 749, 142-149.
https://doi.org/10.1016/j.jorganchem.2013.08.041
Mojic M, Savić A, Arion VB, Bulatović MZ, Poljarević J, Miljkovic D, Sabo T, Mijatovic S, Maksimovic-Ivanic D, Grgurić-Šipka S. Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes. Journal of Organometallic Chemistry. 2014;749:142-149
Mojic Marija, Savić Aleksandar, Arion Vladimir B., Bulatović Mirna Z., Poljarević Jelena, Miljkovic Djordje, Sabo Tibor, Mijatovic Sanja, Maksimovic-Ivanic Danijela, Grgurić-Šipka Sanja, "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes" Journal of Organometallic Chemistry, 749 (2014):142-149,
https://doi.org/10.1016/j.jorganchem.2013.08.041 .
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Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity

Mihajlović-Lalić, Ljiljana; Savić, Aleksandar; Poljarević, Jelena; Vučković, Ivan M.; Mojic, Marija; Bulatović, Mirna Z.; Maksimovic-Ivanic, Danijela; Mijatovic, Sanja; Kaluđerović, Goran N.; Stošić-Grujičić, Stanislava D.; Miljkovic, Dorde; Grgurić-Šipka, Sanja; Sabo, Tibor

(Elsevier Science Inc, New York, 2012)

TY  - JOUR
AU  - Mihajlović-Lalić, Ljiljana
AU  - Savić, Aleksandar
AU  - Poljarević, Jelena
AU  - Vučković, Ivan M.
AU  - Mojic, Marija
AU  - Bulatović, Mirna Z.
AU  - Maksimovic-Ivanic, Danijela
AU  - Mijatovic, Sanja
AU  - Kaluđerović, Goran N.
AU  - Stošić-Grujičić, Stanislava D.
AU  - Miljkovic, Dorde
AU  - Grgurić-Šipka, Sanja
AU  - Sabo, Tibor
PY  - 2012
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1283
AB  - This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.
PB  - Elsevier Science Inc, New York
T2  - Journal of Inorganic Biochemistry
T1  - Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity
VL  - 109
SP  - 40
EP  - 48
DO  - 10.1016/j.jinorgbio.2012.01.012
ER  - 
@article{
author = "Mihajlović-Lalić, Ljiljana and Savić, Aleksandar and Poljarević, Jelena and Vučković, Ivan M. and Mojic, Marija and Bulatović, Mirna Z. and Maksimovic-Ivanic, Danijela and Mijatovic, Sanja and Kaluđerović, Goran N. and Stošić-Grujičić, Stanislava D. and Miljkovic, Dorde and Grgurić-Šipka, Sanja and Sabo, Tibor",
year = "2012",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1283",
abstract = "This paper focuses on the synthesis, characterization and biological activity of new N,N'-methylene modified cyclohexyl ethylenediamine-N,N'-diacetate (edda)-type ligands and their Pt(IV) complexes. Both the ligands and complexes were characterized by infrared, UV-vis, ESI-MS, 1D (H-1, C-13, Pt-195) and 2D (COSY, HSQC, HMBC) NMR spectroscopy and elemental analysis. The possible correlation between the reduction potentials and the cytotoxicity of the complexes was examined. The potential antitumoral activity of all compounds was tested in vitro on human melanoma A375, human glioblastoma U251, human prostate cancer PC3, human colon cancer HCT116, mouse melanoma B16 and mouse colon cancer CT26CL25 cells, as well as primary fibroblasts and keratinocytes. The results obtained revealed strong antitumor potential of the newly synthesized drugs with preserved efficacy against cisplatin resistant lines and less toxicity towards nonmalignant counterparts. The mechanism found to be responsible for the observed tumoricidal action of each synthesized compound was induction of apoptosis generally accompanied with caspase activation. Taken together, the effective response to the treatment of a wide range of different cell lines, including cisplatin resistant subclones, as well as induction of apoptosis, as the mechanism suggested to be the most desirable way of eliminating malignant cells, represents a great advantage of this novel group of drugs in comparison to other members in this metallo-drug family. (C) 2012 Elsevier Inc. All rights reserved.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity",
volume = "109",
pages = "40-48",
doi = "10.1016/j.jinorgbio.2012.01.012"
}
Mihajlović-Lalić, L., Savić, A., Poljarević, J., Vučković, I. M., Mojic, M., Bulatović, M. Z., Maksimovic-Ivanic, D., Mijatovic, S., Kaluđerović, G. N., Stošić-Grujičić, S. D., Miljkovic, D., Grgurić-Šipka, S.,& Sabo, T. (2012). Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity.
Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 109, 40-48.
https://doi.org/10.1016/j.jinorgbio.2012.01.012
Mihajlović-Lalić L, Savić A, Poljarević J, Vučković IM, Mojic M, Bulatović MZ, Maksimovic-Ivanic D, Mijatovic S, Kaluđerović GN, Stošić-Grujičić SD, Miljkovic D, Grgurić-Šipka S, Sabo T. Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity. Journal of Inorganic Biochemistry. 2012;109:40-48
Mihajlović-Lalić Ljiljana, Savić Aleksandar, Poljarević Jelena, Vučković Ivan M., Mojic Marija, Bulatović Mirna Z., Maksimovic-Ivanic Danijela, Mijatovic Sanja, Kaluđerović Goran N., Stošić-Grujičić Stanislava D., Miljkovic Dorde, Grgurić-Šipka Sanja, Sabo Tibor, "Novel methylene modified cyclohexyl ethylenediamine-N,N '-diacetate ligands and their platinum(IV) complexes. Influence on biological activity" Journal of Inorganic Biochemistry, 109 (2012):40-48,
https://doi.org/10.1016/j.jinorgbio.2012.01.012 .
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Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells

Kaluđerović, Goran N.; Mijatovic, Sanja A.; Zmejkovski, Bojana B.; Bulatović, Mirna Z.; Gomez-Ruiz, Santiago; Mojic, Marija K.; Steinborn, Dirk; Miljkovic, Djordje M.; Schmidt, Harry; Stošić-Grujičić, Stanislava D.; Sabo, Tibor; Maksimovic-Ivanic, Danijela D.

(Royal Soc Chemistry, Cambridge, 2012)

TY  - JOUR
AU  - Kaluđerović, Goran N.
AU  - Mijatovic, Sanja A.
AU  - Zmejkovski, Bojana B.
AU  - Bulatović, Mirna Z.
AU  - Gomez-Ruiz, Santiago
AU  - Mojic, Marija K.
AU  - Steinborn, Dirk
AU  - Miljkovic, Djordje M.
AU  - Schmidt, Harry
AU  - Stošić-Grujičić, Stanislava D.
AU  - Sabo, Tibor
AU  - Maksimovic-Ivanic, Danijela D.
PY  - 2012
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1523
AB  - Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.
PB  - Royal Soc Chemistry, Cambridge
T2  - Metallomics
T1  - Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells
VL  - 4
IS  - 9
SP  - 979
EP  - 987
DO  - 10.1039/c2mt20058a
ER  - 
@article{
author = "Kaluđerović, Goran N. and Mijatovic, Sanja A. and Zmejkovski, Bojana B. and Bulatović, Mirna Z. and Gomez-Ruiz, Santiago and Mojic, Marija K. and Steinborn, Dirk and Miljkovic, Djordje M. and Schmidt, Harry and Stošić-Grujičić, Stanislava D. and Sabo, Tibor and Maksimovic-Ivanic, Danijela D.",
year = "2012",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1523",
abstract = "Several new R(2)eddp (R = i-Pr, i-Bu; eddp = ethylenediamine-N,N'-di-3-propionate) esters and corresponding platinum(II) and platinum(IV) complexes of the general formula [PtCln(R(2)edda-type)] (n = 2, 4) were synthesized and characterized by spectroscopic methods (IR, H-1 and C-13 NMR) and elemental analysis. The crystal structure of platinum(IV) complex [PtCl4{(c-Pe)(2)eddip}] (3a) was resolved and is given herein. Ligand precursors, platinum(II), and platinum(IV) complexes were tested against eight tumor cell lines (CT26CL25, HTC116, SW620, PC3, LNCaP, U251, A375, and B16). Selectivity in the action of those compounds between tumor and two normal primary cells (fibroblasts and keratinocytes) are discussed. A structure-activity relationship of these compounds is discussed. Furthermore, cell cycle distribution, induction of necrosis, apoptosis, autophagy, anoikis, caspase activation, ROS, and RNS are presented on the cisplatin-resistant colon carcinoma HCT116 cell line.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Metallomics",
title = "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells",
volume = "4",
number = "9",
pages = "979-987",
doi = "10.1039/c2mt20058a"
}
Kaluđerović, G. N., Mijatovic, S. A., Zmejkovski, B. B., Bulatović, M. Z., Gomez-Ruiz, S., Mojic, M. K., Steinborn, D., Miljkovic, D. M., Schmidt, H., Stošić-Grujičić, S. D., Sabo, T.,& Maksimovic-Ivanic, D. D. (2012). Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells.
Metallomics
Royal Soc Chemistry, Cambridge., 4(9), 979-987.
https://doi.org/10.1039/c2mt20058a
Kaluđerović GN, Mijatovic SA, Zmejkovski BB, Bulatović MZ, Gomez-Ruiz S, Mojic MK, Steinborn D, Miljkovic DM, Schmidt H, Stošić-Grujičić SD, Sabo T, Maksimovic-Ivanic DD. Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells. Metallomics. 2012;4(9):979-987
Kaluđerović Goran N., Mijatovic Sanja A., Zmejkovski Bojana B., Bulatović Mirna Z., Gomez-Ruiz Santiago, Mojic Marija K., Steinborn Dirk, Miljkovic Djordje M., Schmidt Harry, Stošić-Grujičić Stanislava D., Sabo Tibor, Maksimovic-Ivanic Danijela D., "Platinum(II/IV) complexes containing ethylenediamine-N,N '-di-2/3-propionate ester ligands induced caspase-dependent apoptosis in cisplatin-resistant colon cancer cells" Metallomics, 4, no. 9 (2012):979-987,
https://doi.org/10.1039/c2mt20058a .
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32

Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations

Maksimovic-Ivanic, Danijela; Mijatovic, Sanja; Mirkov, Ivana; Stošić-Grujičić, Stanislava D.; Miljkovic, Djordje; Sabo, Tibor; Trajković, Vladimir S.; Kaluđerović, Goran N.

(Royal Soc Chemistry, Cambridge, 2012)

TY  - JOUR
AU  - Maksimovic-Ivanic, Danijela
AU  - Mijatovic, Sanja
AU  - Mirkov, Ivana
AU  - Stošić-Grujičić, Stanislava D.
AU  - Miljkovic, Djordje
AU  - Sabo, Tibor
AU  - Trajković, Vladimir S.
AU  - Kaluđerović, Goran N.
PY  - 2012
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1551
AB  - Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity.
PB  - Royal Soc Chemistry, Cambridge
T2  - Metallomics
T1  - Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations
VL  - 4
IS  - 11
SP  - 1155
EP  - 1159
DO  - 10.1039/c2mt20150j
ER  - 
@article{
author = "Maksimovic-Ivanic, Danijela and Mijatovic, Sanja and Mirkov, Ivana and Stošić-Grujičić, Stanislava D. and Miljkovic, Djordje and Sabo, Tibor and Trajković, Vladimir S. and Kaluđerović, Goran N.",
year = "2012",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1551",
abstract = "Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Metallomics",
title = "Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations",
volume = "4",
number = "11",
pages = "1155-1159",
doi = "10.1039/c2mt20150j"
}
Maksimovic-Ivanic, D., Mijatovic, S., Mirkov, I., Stošić-Grujičić, S. D., Miljkovic, D., Sabo, T., Trajković, V. S.,& Kaluđerović, G. N. (2012). Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations.
Metallomics
Royal Soc Chemistry, Cambridge., 4(11), 1155-1159.
https://doi.org/10.1039/c2mt20150j
Maksimovic-Ivanic D, Mijatovic S, Mirkov I, Stošić-Grujičić SD, Miljkovic D, Sabo T, Trajković VS, Kaluđerović GN. Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations. Metallomics. 2012;4(11):1155-1159
Maksimovic-Ivanic Danijela, Mijatovic Sanja, Mirkov Ivana, Stošić-Grujičić Stanislava D., Miljkovic Djordje, Sabo Tibor, Trajković Vladimir S., Kaluđerović Goran N., "Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations" Metallomics, 4, no. 11 (2012):1155-1159,
https://doi.org/10.1039/c2mt20150j .
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Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects

Miljkovic, Djordje; Poljarević, Jelena; Petkovic, Filip; Blazevski, Jana; Momčilović, Miljana; Nikolic, Ivana; Saksida, Tamara; Stošić-Grujičić, Stanislava D.; Grgurić-Šipka, Sanja; Sabo, Tibor

(Elsevier France-Editions Scientifiques Medicales Elsevier, Paris, 2012)

TY  - JOUR
AU  - Miljkovic, Djordje
AU  - Poljarević, Jelena
AU  - Petkovic, Filip
AU  - Blazevski, Jana
AU  - Momčilović, Miljana
AU  - Nikolic, Ivana
AU  - Saksida, Tamara
AU  - Stošić-Grujičić, Stanislava D.
AU  - Grgurić-Šipka, Sanja
AU  - Sabo, Tibor
PY  - 2012
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/1258
AB  - We have recently reported that a novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand has a potent cytotoxic effect on glioma, melanoma and fibrosarcoma cell lines. In this work, we investigated the influence of the Pt(IV) compound on immune cells. We determined its effect on the viability of spleen cells and lymph node cells and on their capability to produce interferon (IFN)-gamma and interleukin (IL)-17. Also, we researched the compound's impact on peritoneal macrophages and generation of NO in these cells. Our results show that the complex has limited influence on cell viability of immune cells, but profound inhibitory effect on the production of examined immune mediators. These results are valuable as they show that the novel Pt(IV) complex applied in concentrations which are effective against tumor cells do not affect immune cell viability. Moreover, they also imply that the complex has immunomodulatory properties. (C) 2011 Elsevier Masson SAS. All rights reserved.
PB  - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2  - European Journal of Medicinal Chemistry
T1  - Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects
VL  - 47
SP  - 194
EP  - 201
DO  - 10.1016/j.ejmech.2011.10.042
ER  - 
@article{
author = "Miljkovic, Djordje and Poljarević, Jelena and Petkovic, Filip and Blazevski, Jana and Momčilović, Miljana and Nikolic, Ivana and Saksida, Tamara and Stošić-Grujičić, Stanislava D. and Grgurić-Šipka, Sanja and Sabo, Tibor",
year = "2012",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/1258",
abstract = "We have recently reported that a novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand has a potent cytotoxic effect on glioma, melanoma and fibrosarcoma cell lines. In this work, we investigated the influence of the Pt(IV) compound on immune cells. We determined its effect on the viability of spleen cells and lymph node cells and on their capability to produce interferon (IFN)-gamma and interleukin (IL)-17. Also, we researched the compound's impact on peritoneal macrophages and generation of NO in these cells. Our results show that the complex has limited influence on cell viability of immune cells, but profound inhibitory effect on the production of examined immune mediators. These results are valuable as they show that the novel Pt(IV) complex applied in concentrations which are effective against tumor cells do not affect immune cell viability. Moreover, they also imply that the complex has immunomodulatory properties. (C) 2011 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "European Journal of Medicinal Chemistry",
title = "Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects",
volume = "47",
pages = "194-201",
doi = "10.1016/j.ejmech.2011.10.042"
}
Miljkovic, D., Poljarević, J., Petkovic, F., Blazevski, J., Momčilović, M., Nikolic, I., Saksida, T., Stošić-Grujičić, S. D., Grgurić-Šipka, S.,& Sabo, T. (2012). Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects.
European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 47, 194-201.
https://doi.org/10.1016/j.ejmech.2011.10.042
Miljkovic D, Poljarević J, Petkovic F, Blazevski J, Momčilović M, Nikolic I, Saksida T, Stošić-Grujičić SD, Grgurić-Šipka S, Sabo T. Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects. European Journal of Medicinal Chemistry. 2012;47:194-201
Miljkovic Djordje, Poljarević Jelena, Petkovic Filip, Blazevski Jana, Momčilović Miljana, Nikolic Ivana, Saksida Tamara, Stošić-Grujičić Stanislava D., Grgurić-Šipka Sanja, Sabo Tibor, "Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects" European Journal of Medicinal Chemistry, 47 (2012):194-201,
https://doi.org/10.1016/j.ejmech.2011.10.042 .
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