Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200168 (University of Belgrade, Faculty of Chemistry)

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Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200168 (University of Belgrade, Faculty of Chemistry) (en)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 451-03-68/2020-14/200168 (Univerzitet u Beogradu, Hemijski fakultet) (sr_RS)
Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 451-03-68/2020-14/200168 (Универзитет у Београду, Хемијски факултет) (sr)
Authors

Publications

Authenticity assessment of cultivated berries via phenolic profiles of seeds

Krstić, Đurđa D.; Ristivojević, Petar; Gašić, Uroš M.; Lazović, Mila; Fotirić Akšić, Milica M.; Milivojević, Jasminka; Morlock, Gertrud E.; Milojković-Opsenica, Dušanka M.; Trifković, Jelena

(Elsevier, 2023)

TY  - JOUR
AU  - Krstić, Đurđa D.
AU  - Ristivojević, Petar
AU  - Gašić, Uroš M.
AU  - Lazović, Mila
AU  - Fotirić Akšić, Milica M.
AU  - Milivojević, Jasminka
AU  - Morlock, Gertrud E.
AU  - Milojković-Opsenica, Dušanka M.
AU  - Trifković, Jelena
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5629
AB  - Considering the health-benefits of berry fruits consumption and increased market demands for food authenticity
as one of the most important quality assurances, phenolic profiling by high-performance thin layer chroma-
tography and ultra-high-performance liquid chromatography hyphenated with mass spectrometry was combined
with multivariate analysis for phytochemical characterization and intercultivar discrimination of cultivated
berry seeds. The phenolic profiles of 45 berry seeds from nine genuine Serbian cultivated fruit species (straw-
berry, raspberry, blackberry, black currant, blueberry, gooseberry, cape gooseberry, chokeberry, and goji berry)
revealed a good differentiation according to botanical origin. In order to determine biomarkers responsible for
the classification, a total of 103 phenolic compounds were identified, including 53 phenolic acids and their
derivatives, 26 flavonoids and 24 glycosides. Biomarkers derived from the phenolic profile of berry seeds proved
to be a powerful tool in the authentication of botanical origin, and may be useful in detection of frauds in berry-
based seed-containing product.
PB  - Elsevier
T2  - Food Chemistry
T1  - Authenticity assessment of cultivated berries via phenolic profiles of seeds
VL  - 402
SP  - 134184
DO  - 10.1016/j.foodchem.2022.134184
ER  - 
@article{
author = "Krstić, Đurđa D. and Ristivojević, Petar and Gašić, Uroš M. and Lazović, Mila and Fotirić Akšić, Milica M. and Milivojević, Jasminka and Morlock, Gertrud E. and Milojković-Opsenica, Dušanka M. and Trifković, Jelena",
year = "2023",
abstract = "Considering the health-benefits of berry fruits consumption and increased market demands for food authenticity
as one of the most important quality assurances, phenolic profiling by high-performance thin layer chroma-
tography and ultra-high-performance liquid chromatography hyphenated with mass spectrometry was combined
with multivariate analysis for phytochemical characterization and intercultivar discrimination of cultivated
berry seeds. The phenolic profiles of 45 berry seeds from nine genuine Serbian cultivated fruit species (straw-
berry, raspberry, blackberry, black currant, blueberry, gooseberry, cape gooseberry, chokeberry, and goji berry)
revealed a good differentiation according to botanical origin. In order to determine biomarkers responsible for
the classification, a total of 103 phenolic compounds were identified, including 53 phenolic acids and their
derivatives, 26 flavonoids and 24 glycosides. Biomarkers derived from the phenolic profile of berry seeds proved
to be a powerful tool in the authentication of botanical origin, and may be useful in detection of frauds in berry-
based seed-containing product.",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Authenticity assessment of cultivated berries via phenolic profiles of seeds",
volume = "402",
pages = "134184",
doi = "10.1016/j.foodchem.2022.134184"
}
Krstić, Đ. D., Ristivojević, P., Gašić, U. M., Lazović, M., Fotirić Akšić, M. M., Milivojević, J., Morlock, G. E., Milojković-Opsenica, D. M.,& Trifković, J.. (2023). Authenticity assessment of cultivated berries via phenolic profiles of seeds. in Food Chemistry
Elsevier., 402, 134184.
https://doi.org/10.1016/j.foodchem.2022.134184
Krstić ĐD, Ristivojević P, Gašić UM, Lazović M, Fotirić Akšić MM, Milivojević J, Morlock GE, Milojković-Opsenica DM, Trifković J. Authenticity assessment of cultivated berries via phenolic profiles of seeds. in Food Chemistry. 2023;402:134184.
doi:10.1016/j.foodchem.2022.134184 .
Krstić, Đurđa D., Ristivojević, Petar, Gašić, Uroš M., Lazović, Mila, Fotirić Akšić, Milica M., Milivojević, Jasminka, Morlock, Gertrud E., Milojković-Opsenica, Dušanka M., Trifković, Jelena, "Authenticity assessment of cultivated berries via phenolic profiles of seeds" in Food Chemistry, 402 (2023):134184,
https://doi.org/10.1016/j.foodchem.2022.134184 . .

Supplementary material for: Krstić, Đ. D., Ristivojević, P. M., Gašić, U. M., Lazović, M., Fotirić Akšić, M. M., Milivojević, J., Morlock, G. E., Milojković-Opsenica, D. M.,& Trifković, J. Đ.. (2023). Authenticity assessment of cultivated berries via phenolic profiles of seeds. in Food Chemistry Elsevier., 402, 134184. https://doi.org/10.1016/j.foodchem.2022.134184

Krstić, Đurđa D.; Ristivojević, Petar; Gašić, Uroš M.; Lazović, Mila; Fotirić Akšić, Milica M.; Milivojević, Jasminka; Morlock, Gertrud E.; Milojković-Opsenica, Dušanka M.; Trifković, Jelena

(Elsevier, 2023)

TY  - DATA
AU  - Krstić, Đurđa D.
AU  - Ristivojević, Petar
AU  - Gašić, Uroš M.
AU  - Lazović, Mila
AU  - Fotirić Akšić, Milica M.
AU  - Milivojević, Jasminka
AU  - Morlock, Gertrud E.
AU  - Milojković-Opsenica, Dušanka M.
AU  - Trifković, Jelena
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5633
AB  - Considering the health-benefits of berry fruits consumption and increased market demands for food authenticityas one of the most important quality assurances, phenolic profiling by high-performance thin layer chroma-tography and ultra-high-performance liquid chromatography hyphenated with mass spectrometry was combinedwith multivariate analysis for phytochemical characterization and intercultivar discrimination of cultivatedberry seeds. The phenolic profiles of 45 berry seeds from nine genuine Serbian cultivated fruit species (straw-berry, raspberry, blackberry, black currant, blueberry, gooseberry, cape gooseberry, chokeberry, and goji berry)revealed a good differentiation according to botanical origin. In order to determine biomarkers responsible forthe classification, a total of 103 phenolic compounds were identified, including 53 phenolic acids and theirderivatives, 26 flavonoids and 24 glycosides. Biomarkers derived from the phenolic profile of berry seeds provedto be a powerful tool in the authentication of botanical origin, and may be useful in detection of frauds in berry-based seed-containing product.
PB  - Elsevier
T2  - Food Chemistry
T1  - Supplementary material for: Krstić, Đ. D., Ristivojević, P. M., Gašić, U. M., Lazović, M., Fotirić Akšić, M. M., Milivojević, J., Morlock, G. E., Milojković-Opsenica, D. M.,& Trifković, J. Đ.. (2023). Authenticity assessment of cultivated berries via phenolic profiles of seeds. in Food Chemistry Elsevier., 402, 134184. https://doi.org/10.1016/j.foodchem.2022.134184
VL  - 402
SP  - 134184
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5633
ER  - 
@misc{
author = "Krstić, Đurđa D. and Ristivojević, Petar and Gašić, Uroš M. and Lazović, Mila and Fotirić Akšić, Milica M. and Milivojević, Jasminka and Morlock, Gertrud E. and Milojković-Opsenica, Dušanka M. and Trifković, Jelena",
year = "2023",
abstract = "Considering the health-benefits of berry fruits consumption and increased market demands for food authenticityas one of the most important quality assurances, phenolic profiling by high-performance thin layer chroma-tography and ultra-high-performance liquid chromatography hyphenated with mass spectrometry was combinedwith multivariate analysis for phytochemical characterization and intercultivar discrimination of cultivatedberry seeds. The phenolic profiles of 45 berry seeds from nine genuine Serbian cultivated fruit species (straw-berry, raspberry, blackberry, black currant, blueberry, gooseberry, cape gooseberry, chokeberry, and goji berry)revealed a good differentiation according to botanical origin. In order to determine biomarkers responsible forthe classification, a total of 103 phenolic compounds were identified, including 53 phenolic acids and theirderivatives, 26 flavonoids and 24 glycosides. Biomarkers derived from the phenolic profile of berry seeds provedto be a powerful tool in the authentication of botanical origin, and may be useful in detection of frauds in berry-based seed-containing product.",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Supplementary material for: Krstić, Đ. D., Ristivojević, P. M., Gašić, U. M., Lazović, M., Fotirić Akšić, M. M., Milivojević, J., Morlock, G. E., Milojković-Opsenica, D. M.,& Trifković, J. Đ.. (2023). Authenticity assessment of cultivated berries via phenolic profiles of seeds. in Food Chemistry Elsevier., 402, 134184. https://doi.org/10.1016/j.foodchem.2022.134184",
volume = "402",
pages = "134184",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5633"
}
Krstić, Đ. D., Ristivojević, P., Gašić, U. M., Lazović, M., Fotirić Akšić, M. M., Milivojević, J., Morlock, G. E., Milojković-Opsenica, D. M.,& Trifković, J.. (2023). Supplementary material for: Krstić, Đ. D., Ristivojević, P. M., Gašić, U. M., Lazović, M., Fotirić Akšić, M. M., Milivojević, J., Morlock, G. E., Milojković-Opsenica, D. M.,& Trifković, J. Đ.. (2023). Authenticity assessment of cultivated berries via phenolic profiles of seeds. in Food Chemistry Elsevier., 402, 134184. https://doi.org/10.1016/j.foodchem.2022.134184. in Food Chemistry
Elsevier., 402, 134184.
https://hdl.handle.net/21.15107/rcub_cherry_5633
Krstić ĐD, Ristivojević P, Gašić UM, Lazović M, Fotirić Akšić MM, Milivojević J, Morlock GE, Milojković-Opsenica DM, Trifković J. Supplementary material for: Krstić, Đ. D., Ristivojević, P. M., Gašić, U. M., Lazović, M., Fotirić Akšić, M. M., Milivojević, J., Morlock, G. E., Milojković-Opsenica, D. M.,& Trifković, J. Đ.. (2023). Authenticity assessment of cultivated berries via phenolic profiles of seeds. in Food Chemistry Elsevier., 402, 134184. https://doi.org/10.1016/j.foodchem.2022.134184. in Food Chemistry. 2023;402:134184.
https://hdl.handle.net/21.15107/rcub_cherry_5633 .
Krstić, Đurđa D., Ristivojević, Petar, Gašić, Uroš M., Lazović, Mila, Fotirić Akšić, Milica M., Milivojević, Jasminka, Morlock, Gertrud E., Milojković-Opsenica, Dušanka M., Trifković, Jelena, "Supplementary material for: Krstić, Đ. D., Ristivojević, P. M., Gašić, U. M., Lazović, M., Fotirić Akšić, M. M., Milivojević, J., Morlock, G. E., Milojković-Opsenica, D. M.,& Trifković, J. Đ.. (2023). Authenticity assessment of cultivated berries via phenolic profiles of seeds. in Food Chemistry Elsevier., 402, 134184. https://doi.org/10.1016/j.foodchem.2022.134184" in Food Chemistry, 402 (2023):134184,
https://hdl.handle.net/21.15107/rcub_cherry_5633 .

Supplementary material for: Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules MDPI., 27, 6062. https://doi.org/10.3390/molecules27186062

Ristivojević, Petar; Lekić, Nevena; Cvijetić, Ilija; Krstić, Đurđa; Andrić, Filip; Milojković-Opsenica, Dušanka; Morlock, Gertrud E.

(MDPI, 2022)

TY  - DATA
AU  - Ristivojević, Petar
AU  - Lekić, Nevena
AU  - Cvijetić, Ilija
AU  - Krstić, Đurđa
AU  - Andrić, Filip
AU  - Milojković-Opsenica, Dušanka
AU  - Morlock, Gertrud E.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5646
AB  - Strawberries are an important fruit in the European diet because of their unique taste and high content of essential nutrients and bioactive compounds. The anthocyanins are known to be colorful phenolics in strawberries. In 17 samples of six strawberry cultivars produced in Serbia, i.e., the common varieties Alba, Asia, and Clery as well as promising breeding materials (11.29.11, 11.34.6, and 11.39.3), the anthocyanin profile as well as antimicrobial and antioxidative activity profiles were determined. All investigated extracts showed antioxidative and antibacterial activities against Gram-negative Aliivibrio fischeri. The responses were quite similar in number and intensity. The HPTLC-DPPH• scavenging assay and HPTLC-Aliivibrio fischeri bioassay coupled with high-resolution mass spectrometry identified pelargonidin-3-O-glucoside (Pg-3-glc) as the main anthocyanin and prominent antioxidative and antimicrobial compound in strawberries. The density functional theory calculations at the M06-2X/6-31+G(d,p) level showed that Pg-3-glc quenches free radicals via sequential proton loss electron transfer mechanism in water and in pentyl ethanoate, where the 5-OH group is the most reactive site for proton and hydrogen atom transfer. The results were confirmed via spectrophotometry. The highest total phenolic content was found in Clery and 11.39.3, while statistically significant differences between the genotypes regarding the antioxidant activity were not confirmed. Although very similar in the anthocyanin, antioxidative, and antimicrobial profile patterns, the strawberry genotypes were successfully classified using principal component analysis.
PB  - MDPI
T2  - Molecules
T1  - Supplementary material for: Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules MDPI., 27, 6062. https://doi.org/10.3390/molecules27186062
VL  - 27
SP  - 6062
ER  - 
@misc{
author = "Ristivojević, Petar and Lekić, Nevena and Cvijetić, Ilija and Krstić, Đurđa and Andrić, Filip and Milojković-Opsenica, Dušanka and Morlock, Gertrud E.",
year = "2022",
abstract = "Strawberries are an important fruit in the European diet because of their unique taste and high content of essential nutrients and bioactive compounds. The anthocyanins are known to be colorful phenolics in strawberries. In 17 samples of six strawberry cultivars produced in Serbia, i.e., the common varieties Alba, Asia, and Clery as well as promising breeding materials (11.29.11, 11.34.6, and 11.39.3), the anthocyanin profile as well as antimicrobial and antioxidative activity profiles were determined. All investigated extracts showed antioxidative and antibacterial activities against Gram-negative Aliivibrio fischeri. The responses were quite similar in number and intensity. The HPTLC-DPPH• scavenging assay and HPTLC-Aliivibrio fischeri bioassay coupled with high-resolution mass spectrometry identified pelargonidin-3-O-glucoside (Pg-3-glc) as the main anthocyanin and prominent antioxidative and antimicrobial compound in strawberries. The density functional theory calculations at the M06-2X/6-31+G(d,p) level showed that Pg-3-glc quenches free radicals via sequential proton loss electron transfer mechanism in water and in pentyl ethanoate, where the 5-OH group is the most reactive site for proton and hydrogen atom transfer. The results were confirmed via spectrophotometry. The highest total phenolic content was found in Clery and 11.39.3, while statistically significant differences between the genotypes regarding the antioxidant activity were not confirmed. Although very similar in the anthocyanin, antioxidative, and antimicrobial profile patterns, the strawberry genotypes were successfully classified using principal component analysis.",
publisher = "MDPI",
journal = "Molecules",
title = "Supplementary material for: Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules MDPI., 27, 6062. https://doi.org/10.3390/molecules27186062",
volume = "27",
pages = "6062"
}
Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Supplementary material for: Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules MDPI., 27, 6062. https://doi.org/10.3390/molecules27186062. in Molecules
MDPI., 27, 6062.
Ristivojević P, Lekić N, Cvijetić I, Krstić Đ, Andrić F, Milojković-Opsenica D, Morlock GE. Supplementary material for: Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules MDPI., 27, 6062. https://doi.org/10.3390/molecules27186062. in Molecules. 2022;27:6062..
Ristivojević, Petar, Lekić, Nevena, Cvijetić, Ilija, Krstić, Đurđa, Andrić, Filip, Milojković-Opsenica, Dušanka, Morlock, Gertrud E., "Supplementary material for: Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules MDPI., 27, 6062. https://doi.org/10.3390/molecules27186062" in Molecules, 27 (2022):6062.

Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics

Ristivojević, Petar; Lekić, Nevena; Cvijetić, Ilija; Krstić, Đurđa; Andrić, Filip; Milojković-Opsenica, Dušanka; Morlock, Gertrud E.

(MDPI, 2022)

TY  - JOUR
AU  - Ristivojević, Petar
AU  - Lekić, Nevena
AU  - Cvijetić, Ilija
AU  - Krstić, Đurđa
AU  - Andrić, Filip
AU  - Milojković-Opsenica, Dušanka
AU  - Morlock, Gertrud E.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5644
AB  - Strawberries are an important fruit in the European diet because of their unique taste and high content of essential nutrients and bioactive compounds. The anthocyanins are known to be colorful phenolics in strawberries. In 17 samples of six strawberry cultivars produced in Serbia, i.e., the common varieties Alba, Asia, and Clery as well as promising breeding materials (11.29.11, 11.34.6, and 11.39.3), the anthocyanin profile as well as antimicrobial and antioxidative activity profiles were determined. All investigated extracts showed antioxidative and antibacterial activities against Gram-negative Aliivibrio fischeri. The responses were quite similar in number and intensity. The HPTLC-DPPH• scavenging assay and HPTLC-Aliivibrio fischeri bioassay coupled with high-resolution mass spectrometry identified pelargonidin-3-O-glucoside (Pg-3-glc) as the main anthocyanin and prominent antioxidative and antimicrobial compound in strawberries. The density functional theory calculations at the M06-2X/6-31+G(d,p) level showed that Pg-3-glc quenches free radicals via sequential proton loss electron transfer mechanism in water and in pentyl ethanoate, where the 5-OH group is the most reactive site for proton and hydrogen atom transfer. The results were confirmed via spectrophotometry. The highest total phenolic content was found in Clery and 11.39.3, while statistically significant differences between the genotypes regarding the antioxidant activity were not confirmed. Although very similar in the anthocyanin, antioxidative, and antimicrobial profile patterns, the strawberry genotypes were successfully classified using principal component analysis.
PB  - MDPI
T2  - Molecules
T1  - Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics
VL  - 27
SP  - 6062
DO  - 10.3390/molecules27186062
ER  - 
@article{
author = "Ristivojević, Petar and Lekić, Nevena and Cvijetić, Ilija and Krstić, Đurđa and Andrić, Filip and Milojković-Opsenica, Dušanka and Morlock, Gertrud E.",
year = "2022",
abstract = "Strawberries are an important fruit in the European diet because of their unique taste and high content of essential nutrients and bioactive compounds. The anthocyanins are known to be colorful phenolics in strawberries. In 17 samples of six strawberry cultivars produced in Serbia, i.e., the common varieties Alba, Asia, and Clery as well as promising breeding materials (11.29.11, 11.34.6, and 11.39.3), the anthocyanin profile as well as antimicrobial and antioxidative activity profiles were determined. All investigated extracts showed antioxidative and antibacterial activities against Gram-negative Aliivibrio fischeri. The responses were quite similar in number and intensity. The HPTLC-DPPH• scavenging assay and HPTLC-Aliivibrio fischeri bioassay coupled with high-resolution mass spectrometry identified pelargonidin-3-O-glucoside (Pg-3-glc) as the main anthocyanin and prominent antioxidative and antimicrobial compound in strawberries. The density functional theory calculations at the M06-2X/6-31+G(d,p) level showed that Pg-3-glc quenches free radicals via sequential proton loss electron transfer mechanism in water and in pentyl ethanoate, where the 5-OH group is the most reactive site for proton and hydrogen atom transfer. The results were confirmed via spectrophotometry. The highest total phenolic content was found in Clery and 11.39.3, while statistically significant differences between the genotypes regarding the antioxidant activity were not confirmed. Although very similar in the anthocyanin, antioxidative, and antimicrobial profile patterns, the strawberry genotypes were successfully classified using principal component analysis.",
publisher = "MDPI",
journal = "Molecules",
title = "Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics",
volume = "27",
pages = "6062",
doi = "10.3390/molecules27186062"
}
Ristivojević, P., Lekić, N., Cvijetić, I., Krstić, Đ., Andrić, F., Milojković-Opsenica, D.,& Morlock, G. E.. (2022). Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules
MDPI., 27, 6062.
https://doi.org/10.3390/molecules27186062
Ristivojević P, Lekić N, Cvijetić I, Krstić Đ, Andrić F, Milojković-Opsenica D, Morlock GE. Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics. in Molecules. 2022;27:6062.
doi:10.3390/molecules27186062 .
Ristivojević, Petar, Lekić, Nevena, Cvijetić, Ilija, Krstić, Đurđa, Andrić, Filip, Milojković-Opsenica, Dušanka, Morlock, Gertrud E., "Effect-Directed Profiling of Strawberry Varieties and Breeding Materials via Planar Chromatography and Chemometrics" in Molecules, 27 (2022):6062,
https://doi.org/10.3390/molecules27186062 . .

Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time

Koprivica, Marija; Milojković-Opsenica, Dušanka; Fotirić Akšić, Milica; Dramićanin, Aleksandra M.; Lazarević, Kristina

(2022)

TY  - JOUR
AU  - Koprivica, Marija
AU  - Milojković-Opsenica, Dušanka
AU  - Fotirić Akšić, Milica
AU  - Dramićanin, Aleksandra M.
AU  - Lazarević, Kristina
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5498
AB  - The peach stones and kernels are easily available biowaste which could be useful for the extraction of nutritionally important compounds such as fatty acids. Except in industry, characterization of stones and kernels could be useful in pomology to describe different cultivars, and for selecting new parents in a breeding program. A total of 25 samples of stones and kernels from various peach cultivars that differed in origin and ripening time, but growing in the same climatic conditions, were characterized by fatty acids composition and physical properties. This work confirmed that unsaturated fatty acids (oleic and linoleic fatty acids) were the most represented in peach kernel oil and their content depended of peach genotype. Additionally, the fatty acids in combination with length, weight, and moisture of peach kernels could be used as a parameter of authenticity assessment. This research may contribute for the peach cultivar discrimination and recommendation of cultivars/genotypes with high kernel quality which could be used for the extractions of oil rich in unsaturated fatty acids and further use in food, pharmaceutical and cosmetic industry. Besides, selected cultivars could be used in breeding programs, for creating new genotypes for oil production.
T2  - European Food Research and Technology
T1  - Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time
VL  - 248
SP  - 2471
EP  - 2482
DO  - 10.1007/s00217-022-04062-3
ER  - 
@article{
author = "Koprivica, Marija and Milojković-Opsenica, Dušanka and Fotirić Akšić, Milica and Dramićanin, Aleksandra M. and Lazarević, Kristina",
year = "2022",
abstract = "The peach stones and kernels are easily available biowaste which could be useful for the extraction of nutritionally important compounds such as fatty acids. Except in industry, characterization of stones and kernels could be useful in pomology to describe different cultivars, and for selecting new parents in a breeding program. A total of 25 samples of stones and kernels from various peach cultivars that differed in origin and ripening time, but growing in the same climatic conditions, were characterized by fatty acids composition and physical properties. This work confirmed that unsaturated fatty acids (oleic and linoleic fatty acids) were the most represented in peach kernel oil and their content depended of peach genotype. Additionally, the fatty acids in combination with length, weight, and moisture of peach kernels could be used as a parameter of authenticity assessment. This research may contribute for the peach cultivar discrimination and recommendation of cultivars/genotypes with high kernel quality which could be used for the extractions of oil rich in unsaturated fatty acids and further use in food, pharmaceutical and cosmetic industry. Besides, selected cultivars could be used in breeding programs, for creating new genotypes for oil production.",
journal = "European Food Research and Technology",
title = "Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time",
volume = "248",
pages = "2471-2482",
doi = "10.1007/s00217-022-04062-3"
}
Koprivica, M., Milojković-Opsenica, D., Fotirić Akšić, M., Dramićanin, A. M.,& Lazarević, K.. (2022). Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time. in European Food Research and Technology, 248, 2471-2482.
https://doi.org/10.1007/s00217-022-04062-3
Koprivica M, Milojković-Opsenica D, Fotirić Akšić M, Dramićanin AM, Lazarević K. Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time. in European Food Research and Technology. 2022;248:2471-2482.
doi:10.1007/s00217-022-04062-3 .
Koprivica, Marija, Milojković-Opsenica, Dušanka, Fotirić Akšić, Milica, Dramićanin, Aleksandra M., Lazarević, Kristina, "Fatty acids composition and physical properties of stones and kernels from different peach cultivars as biomarker of origin and ripening time" in European Food Research and Technology, 248 (2022):2471-2482,
https://doi.org/10.1007/s00217-022-04062-3 . .

To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries

Popović, Aleksandar R.; Anđelković, Boban D.; Đorđević, Dragana S.; Sakan, Sanja M.; Vujisić, Ljubodrag V.; Veličković, Sava; Relić, Dubravka

(2022)

TY  - JOUR
AU  - Popović, Aleksandar R.
AU  - Anđelković, Boban D.
AU  - Đorđević, Dragana S.
AU  - Sakan, Sanja M.
AU  - Vujisić, Ljubodrag V.
AU  - Veličković, Sava
AU  - Relić, Dubravka
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4942
AB  - In order to further define the potential use of FTIR-ATR spectroscopy, as a non-destructive and reliable technique, for the analysis of the characteristics of post stamps, certified originals of the Principality of Serbia stamps (“Prince Michael issues”) issued in 1866 and 1868 as well as their forgeries were ana­lyzed. Spectra enabling the comparison of the paper, dye and glue of stamps of so-called “Vienna issues”, having denominations of 10 (orange-yellow), 20 (pink) and 40 para (blue) and “Belgrade issues” (1 para-green and 2 para-reddish brown), as well as 24 expert-certified forgeries, were taken. It was shown that the applied technology was, in most of the cases, a fast and suitable technique for establishing clear differences between the spectral characteristics of the paper and dye used for the original stamps, and forgeries that were most probably made decades after the printing of the genuine stamps. The differences between print­ings of the same issues of the genuine stamps were also elaborated. It is pro­posed, for the first time in philatelic history, the possibility that “Vienna issues” stamps may have been printed on two different papers, and, having in mind the technology of printing in the 19th century, potentially, not even at the same time or in the same printing house.
T2  - Journal of the Serbian Chemical Society
T1  - To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries
VL  - 87
IS  - 1
SP  - 27
EP  - 40
DO  - 10.2298/JSC210901090P
ER  - 
@article{
author = "Popović, Aleksandar R. and Anđelković, Boban D. and Đorđević, Dragana S. and Sakan, Sanja M. and Vujisić, Ljubodrag V. and Veličković, Sava and Relić, Dubravka",
year = "2022",
abstract = "In order to further define the potential use of FTIR-ATR spectroscopy, as a non-destructive and reliable technique, for the analysis of the characteristics of post stamps, certified originals of the Principality of Serbia stamps (“Prince Michael issues”) issued in 1866 and 1868 as well as their forgeries were ana­lyzed. Spectra enabling the comparison of the paper, dye and glue of stamps of so-called “Vienna issues”, having denominations of 10 (orange-yellow), 20 (pink) and 40 para (blue) and “Belgrade issues” (1 para-green and 2 para-reddish brown), as well as 24 expert-certified forgeries, were taken. It was shown that the applied technology was, in most of the cases, a fast and suitable technique for establishing clear differences between the spectral characteristics of the paper and dye used for the original stamps, and forgeries that were most probably made decades after the printing of the genuine stamps. The differences between print­ings of the same issues of the genuine stamps were also elaborated. It is pro­posed, for the first time in philatelic history, the possibility that “Vienna issues” stamps may have been printed on two different papers, and, having in mind the technology of printing in the 19th century, potentially, not even at the same time or in the same printing house.",
journal = "Journal of the Serbian Chemical Society",
title = "To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries",
volume = "87",
number = "1",
pages = "27-40",
doi = "10.2298/JSC210901090P"
}
Popović, A. R., Anđelković, B. D., Đorđević, D. S., Sakan, S. M., Vujisić, L. V., Veličković, S.,& Relić, D.. (2022). To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries. in Journal of the Serbian Chemical Society, 87(1), 27-40.
https://doi.org/10.2298/JSC210901090P
Popović AR, Anđelković BD, Đorđević DS, Sakan SM, Vujisić LV, Veličković S, Relić D. To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries. in Journal of the Serbian Chemical Society. 2022;87(1):27-40.
doi:10.2298/JSC210901090P .
Popović, Aleksandar R., Anđelković, Boban D., Đorđević, Dragana S., Sakan, Sanja M., Vujisić, Ljubodrag V., Veličković, Sava, Relić, Dubravka, "To Professor Petar Pfendt, In calidum, et plurium retributivus memoriae: FTIR-ATR analysis of post stamps of the Principality of Serbia issued in 1866 and 1868 and their forgeries" in Journal of the Serbian Chemical Society, 87, no. 1 (2022):27-40,
https://doi.org/10.2298/JSC210901090P . .

Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile

Assaleh, Mohamed H.; Bjelogrlić, Snežana K.; Prlainović, Nevena; Cvijetić, Ilija; Božić, Aleksandra R.; Aranđelović, Irena; Vuković, Dragana; Marinković, Aleksandar

(Elsevier, 2022)

TY  - JOUR
AU  - Assaleh, Mohamed H.
AU  - Bjelogrlić, Snežana K.
AU  - Prlainović, Nevena
AU  - Cvijetić, Ilija
AU  - Božić, Aleksandra R.
AU  - Aranđelović, Irena
AU  - Vuković, Dragana
AU  - Marinković, Aleksandar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4867
AB  - A series of twelve novel hybrids of cinnamic acid and thiocarbohydrazones were designed, synthesized in high yield using a simple coupling strategy via acid chlorides, and evaluated for their impact against Mycobacterium tuberculosis (Mtb) and cancer cells survival. Among them, compound 3 demonstrated strong anti-Mtb activity by reducing bacilli survival for>90 % in all three treated Mtb isolates, whereas isoniazid and rifampicin did not. Moreover, compound 3 didn’t affect vitality of HepG-2 cells, implying on advantageous hepatotoxicity profile compared to current therapeutic options for tuberculosis. Compounds 2a and 3b displayed as strong inducers of apoptosis in A549 cells, both activating intrinsic caspase pathway and cell cycle arrest at the G0/G1 phase. Subsequent analyses disclosed differences in their activities, where 3b has ability to induce production of mitochondrial superoxide anions, while 2a significantly inhibited cellular mobility. More importantly, 3b considerably affected viability of HepG-2 and HaCaT cells, whereas 2a had moderate impact only on the later. Molecular modeling studies indicated high permeability and good absorption through the human intestine, and moderate aqueous solubility with poor blood–brain barrier permeability. In summary, our results reveal that novel compounds 3 and 2a represent promising agents for tuberculosis and cancer treatment, respectively, indicating that further investigation needs to be performed to clarify the mechanisms of their anti-Mtb and anticancer activity.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile
VL  - 15
IS  - 1
SP  - 103532
DO  - 10.1016/j.arabjc.2021.103532
ER  - 
@article{
author = "Assaleh, Mohamed H. and Bjelogrlić, Snežana K. and Prlainović, Nevena and Cvijetić, Ilija and Božić, Aleksandra R. and Aranđelović, Irena and Vuković, Dragana and Marinković, Aleksandar",
year = "2022",
abstract = "A series of twelve novel hybrids of cinnamic acid and thiocarbohydrazones were designed, synthesized in high yield using a simple coupling strategy via acid chlorides, and evaluated for their impact against Mycobacterium tuberculosis (Mtb) and cancer cells survival. Among them, compound 3 demonstrated strong anti-Mtb activity by reducing bacilli survival for>90 % in all three treated Mtb isolates, whereas isoniazid and rifampicin did not. Moreover, compound 3 didn’t affect vitality of HepG-2 cells, implying on advantageous hepatotoxicity profile compared to current therapeutic options for tuberculosis. Compounds 2a and 3b displayed as strong inducers of apoptosis in A549 cells, both activating intrinsic caspase pathway and cell cycle arrest at the G0/G1 phase. Subsequent analyses disclosed differences in their activities, where 3b has ability to induce production of mitochondrial superoxide anions, while 2a significantly inhibited cellular mobility. More importantly, 3b considerably affected viability of HepG-2 and HaCaT cells, whereas 2a had moderate impact only on the later. Molecular modeling studies indicated high permeability and good absorption through the human intestine, and moderate aqueous solubility with poor blood–brain barrier permeability. In summary, our results reveal that novel compounds 3 and 2a represent promising agents for tuberculosis and cancer treatment, respectively, indicating that further investigation needs to be performed to clarify the mechanisms of their anti-Mtb and anticancer activity.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile",
volume = "15",
number = "1",
pages = "103532",
doi = "10.1016/j.arabjc.2021.103532"
}
Assaleh, M. H., Bjelogrlić, S. K., Prlainović, N., Cvijetić, I., Božić, A. R., Aranđelović, I., Vuković, D.,& Marinković, A.. (2022). Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile. in Arabian Journal of Chemistry
Elsevier., 15(1), 103532.
https://doi.org/10.1016/j.arabjc.2021.103532
Assaleh MH, Bjelogrlić SK, Prlainović N, Cvijetić I, Božić AR, Aranđelović I, Vuković D, Marinković A. Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile. in Arabian Journal of Chemistry. 2022;15(1):103532.
doi:10.1016/j.arabjc.2021.103532 .
Assaleh, Mohamed H., Bjelogrlić, Snežana K., Prlainović, Nevena, Cvijetić, Ilija, Božić, Aleksandra R., Aranđelović, Irena, Vuković, Dragana, Marinković, Aleksandar, "Antimycobacterial and anticancer activity of newly designed cinnamic acid hydrazides with favorable toxicity profile" in Arabian Journal of Chemistry, 15, no. 1 (2022):103532,
https://doi.org/10.1016/j.arabjc.2021.103532 . .
1
1

Supplementary material for the article: Assaleh, M. H.; Bjelogrlic, S. K.; Prlainovic, N.; Cvijetic, I.; Bozic, A.; Arandjelovic, I.; Vukovic, D.; Marinkovic, A. Antimycobacterial and Anticancer Activity of Newly Designed Cinnamic Acid Hydrazides with Favorable Toxicity Profile. Arabian Journal of Chemistry 2022, 15 (1), 103532. https://doi.org/10.1016/j.arabjc.2021.103532.

Assaleh, Mohamed H.; Bjelogrlić, Snežana K.; Prlainović, Nevena; Cvijetić, Ilija; Božić, Aleksandra R.; Aranđelović, Irena; Vuković, Dragana; Marinković, Aleksandar

(Elsevier, 2022)

TY  - DATA
AU  - Assaleh, Mohamed H.
AU  - Bjelogrlić, Snežana K.
AU  - Prlainović, Nevena
AU  - Cvijetić, Ilija
AU  - Božić, Aleksandra R.
AU  - Aranđelović, Irena
AU  - Vuković, Dragana
AU  - Marinković, Aleksandar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4868
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for the article: Assaleh, M. H.; Bjelogrlic, S. K.; Prlainovic, N.; Cvijetic, I.; Bozic, A.; Arandjelovic, I.; Vukovic, D.; Marinkovic, A. Antimycobacterial and Anticancer Activity of Newly Designed Cinnamic Acid Hydrazides with Favorable Toxicity Profile. Arabian Journal of Chemistry 2022, 15 (1), 103532. https://doi.org/10.1016/j.arabjc.2021.103532.
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4868
ER  - 
@misc{
author = "Assaleh, Mohamed H. and Bjelogrlić, Snežana K. and Prlainović, Nevena and Cvijetić, Ilija and Božić, Aleksandra R. and Aranđelović, Irena and Vuković, Dragana and Marinković, Aleksandar",
year = "2022",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for the article: Assaleh, M. H.; Bjelogrlic, S. K.; Prlainovic, N.; Cvijetic, I.; Bozic, A.; Arandjelovic, I.; Vukovic, D.; Marinkovic, A. Antimycobacterial and Anticancer Activity of Newly Designed Cinnamic Acid Hydrazides with Favorable Toxicity Profile. Arabian Journal of Chemistry 2022, 15 (1), 103532. https://doi.org/10.1016/j.arabjc.2021.103532.",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4868"
}
Assaleh, M. H., Bjelogrlić, S. K., Prlainović, N., Cvijetić, I., Božić, A. R., Aranđelović, I., Vuković, D.,& Marinković, A.. (2022). Supplementary material for the article: Assaleh, M. H.; Bjelogrlic, S. K.; Prlainovic, N.; Cvijetic, I.; Bozic, A.; Arandjelovic, I.; Vukovic, D.; Marinkovic, A. Antimycobacterial and Anticancer Activity of Newly Designed Cinnamic Acid Hydrazides with Favorable Toxicity Profile. Arabian Journal of Chemistry 2022, 15 (1), 103532. https://doi.org/10.1016/j.arabjc.2021.103532.. in Arabian Journal of Chemistry
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4868
Assaleh MH, Bjelogrlić SK, Prlainović N, Cvijetić I, Božić AR, Aranđelović I, Vuković D, Marinković A. Supplementary material for the article: Assaleh, M. H.; Bjelogrlic, S. K.; Prlainovic, N.; Cvijetic, I.; Bozic, A.; Arandjelovic, I.; Vukovic, D.; Marinkovic, A. Antimycobacterial and Anticancer Activity of Newly Designed Cinnamic Acid Hydrazides with Favorable Toxicity Profile. Arabian Journal of Chemistry 2022, 15 (1), 103532. https://doi.org/10.1016/j.arabjc.2021.103532.. in Arabian Journal of Chemistry. 2022;.
https://hdl.handle.net/21.15107/rcub_cherry_4868 .
Assaleh, Mohamed H., Bjelogrlić, Snežana K., Prlainović, Nevena, Cvijetić, Ilija, Božić, Aleksandra R., Aranđelović, Irena, Vuković, Dragana, Marinković, Aleksandar, "Supplementary material for the article: Assaleh, M. H.; Bjelogrlic, S. K.; Prlainovic, N.; Cvijetic, I.; Bozic, A.; Arandjelovic, I.; Vukovic, D.; Marinkovic, A. Antimycobacterial and Anticancer Activity of Newly Designed Cinnamic Acid Hydrazides with Favorable Toxicity Profile. Arabian Journal of Chemistry 2022, 15 (1), 103532. https://doi.org/10.1016/j.arabjc.2021.103532." in Arabian Journal of Chemistry (2022),
https://hdl.handle.net/21.15107/rcub_cherry_4868 .

Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products

Selaković, Života; Nikolić, Andrea; Ajdačić, Vladimir; Opsenica, Igor

(Wiley, 2022)

TY  - JOUR
AU  - Selaković, Života
AU  - Nikolić, Andrea
AU  - Ajdačić, Vladimir
AU  - Opsenica, Igor
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4871
AB  - Decarbonylation is an invaluable reaction, utilized by nature and chemists alike. In different life forms, such as prokaryotes, plants and animals, this transformation is catalyzed by aldehyde decarbonylases. In the laboratory, the transition metal-catalyzed (TMC) decarbonylation, which was first achieved in 1959, is by and large the dominant way for conducting this reaction. The carbon-carbon bond cleavage is most often made possible by RhCl(PPh3)3 i. e. Wilkinson's catalyst, but other metals are also used, both in academia and in industry. In this review, we chose to present the applications of TMC decarbonylation in the synthesis of natural products and their derivatives. More than 30 examples are showcased and categorized into three categories based on the essence of the role of the aldehyde group in the synthesis. A short outlook is given in the end, listing the different advantages and disadvantages of Wilkinson's catalyst, as well as offering a brief prospect for the future.
PB  - Wiley
T2  - European Journal of Organic Chemistry
T1  - Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products
VL  - 2022
IS  - 1
SP  - e202101265
DO  - 10.1002/ejoc.202101265
ER  - 
@article{
author = "Selaković, Života and Nikolić, Andrea and Ajdačić, Vladimir and Opsenica, Igor",
year = "2022",
abstract = "Decarbonylation is an invaluable reaction, utilized by nature and chemists alike. In different life forms, such as prokaryotes, plants and animals, this transformation is catalyzed by aldehyde decarbonylases. In the laboratory, the transition metal-catalyzed (TMC) decarbonylation, which was first achieved in 1959, is by and large the dominant way for conducting this reaction. The carbon-carbon bond cleavage is most often made possible by RhCl(PPh3)3 i. e. Wilkinson's catalyst, but other metals are also used, both in academia and in industry. In this review, we chose to present the applications of TMC decarbonylation in the synthesis of natural products and their derivatives. More than 30 examples are showcased and categorized into three categories based on the essence of the role of the aldehyde group in the synthesis. A short outlook is given in the end, listing the different advantages and disadvantages of Wilkinson's catalyst, as well as offering a brief prospect for the future.",
publisher = "Wiley",
journal = "European Journal of Organic Chemistry",
title = "Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products",
volume = "2022",
number = "1",
pages = "e202101265",
doi = "10.1002/ejoc.202101265"
}
Selaković, Ž., Nikolić, A., Ajdačić, V.,& Opsenica, I.. (2022). Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products. in European Journal of Organic Chemistry
Wiley., 2022(1), e202101265.
https://doi.org/10.1002/ejoc.202101265
Selaković Ž, Nikolić A, Ajdačić V, Opsenica I. Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products. in European Journal of Organic Chemistry. 2022;2022(1):e202101265.
doi:10.1002/ejoc.202101265 .
Selaković, Života, Nikolić, Andrea, Ajdačić, Vladimir, Opsenica, Igor, "Application of Transition Metal-Catalyzed Decarbonylation of Aldehydes in the Total Synthesis of Natural Products" in European Journal of Organic Chemistry, 2022, no. 1 (2022):e202101265,
https://doi.org/10.1002/ejoc.202101265 . .
5
1
1

A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels

Nešić, Andrijana; Stojsavljević, Aleksandar; Jagodić, Jovana; Čavić, Milena; Stefanović, Aleksandra; Manojlović, Dragan; Gavrović-Jankulović, Marija

(Elsevier, 2022)

TY  - JOUR
AU  - Nešić, Andrijana
AU  - Stojsavljević, Aleksandar
AU  - Jagodić, Jovana
AU  - Čavić, Milena
AU  - Stefanović, Aleksandra
AU  - Manojlović, Dragan
AU  - Gavrović-Jankulović, Marija
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5636
AB  - Background: Although essential trace elements (ETEs) play pivotal roles in life-supporting biochemical processes, their function in innate and adaptive immunity has not been fully elucidated, particularly during immunization. Furthermore, the association between anti-SARS-CoV-2 specific IgG antibodies and ETE levels with vaccine responsiveness has not been investigated. Methods: The present study explored the status of ETEs (Mn, Cu, Zn, and Se) in sera of healthy women before and after vaccination with the anti-SARS-CoV-2 BNT162b2 mRNA vaccine in a follow-up period of six months. The main aim was to explore links between ETE levels and IgG antibodies produced against Spike glycoprotein's Receptor-Binding Domain (RBD). Results: A recombinant protein of SARS-CoV-2 comprising the receptor binding domain was successfully expressed in HEK-293 T cells. The purified protein was suitable for producing a sensitive antibody detection assay for human serum and monitored seropositivity, indicating a transient response with peak anti-SARS-CoV-2 IgG levels 2 months after vaccination. In parallel to increasing antibody titers, serum concentrations of Cu, Mn, and Se were not affected by vaccination, and concentrations remained relatively constant at the different sampling times during the 6-month observation period. Total serum Zn concentrations were slightly elevated when compared between the first and last sampling dates. Overall, no consistent effects of vaccination on any of the three trace elements analyzed in our study were observed. Conclusion: Vaccination of adult healthy female volunteers with an mRNA vaccine was not associated with consistent changes in serum trace element concentrations over a six-month observation period.
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T1  - A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels
VL  - 74
SP  - 127079
DO  - 10.1016/j.jtemb.2022.127079
ER  - 
@article{
author = "Nešić, Andrijana and Stojsavljević, Aleksandar and Jagodić, Jovana and Čavić, Milena and Stefanović, Aleksandra and Manojlović, Dragan and Gavrović-Jankulović, Marija",
year = "2022",
abstract = "Background: Although essential trace elements (ETEs) play pivotal roles in life-supporting biochemical processes, their function in innate and adaptive immunity has not been fully elucidated, particularly during immunization. Furthermore, the association between anti-SARS-CoV-2 specific IgG antibodies and ETE levels with vaccine responsiveness has not been investigated. Methods: The present study explored the status of ETEs (Mn, Cu, Zn, and Se) in sera of healthy women before and after vaccination with the anti-SARS-CoV-2 BNT162b2 mRNA vaccine in a follow-up period of six months. The main aim was to explore links between ETE levels and IgG antibodies produced against Spike glycoprotein's Receptor-Binding Domain (RBD). Results: A recombinant protein of SARS-CoV-2 comprising the receptor binding domain was successfully expressed in HEK-293 T cells. The purified protein was suitable for producing a sensitive antibody detection assay for human serum and monitored seropositivity, indicating a transient response with peak anti-SARS-CoV-2 IgG levels 2 months after vaccination. In parallel to increasing antibody titers, serum concentrations of Cu, Mn, and Se were not affected by vaccination, and concentrations remained relatively constant at the different sampling times during the 6-month observation period. Total serum Zn concentrations were slightly elevated when compared between the first and last sampling dates. Overall, no consistent effects of vaccination on any of the three trace elements analyzed in our study were observed. Conclusion: Vaccination of adult healthy female volunteers with an mRNA vaccine was not associated with consistent changes in serum trace element concentrations over a six-month observation period.",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology",
title = "A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels",
volume = "74",
pages = "127079",
doi = "10.1016/j.jtemb.2022.127079"
}
Nešić, A., Stojsavljević, A., Jagodić, J., Čavić, M., Stefanović, A., Manojlović, D.,& Gavrović-Jankulović, M.. (2022). A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels. in Journal of Trace Elements in Medicine and Biology
Elsevier., 74, 127079.
https://doi.org/10.1016/j.jtemb.2022.127079
Nešić A, Stojsavljević A, Jagodić J, Čavić M, Stefanović A, Manojlović D, Gavrović-Jankulović M. A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels. in Journal of Trace Elements in Medicine and Biology. 2022;74:127079.
doi:10.1016/j.jtemb.2022.127079 .
Nešić, Andrijana, Stojsavljević, Aleksandar, Jagodić, Jovana, Čavić, Milena, Stefanović, Aleksandra, Manojlović, Dragan, Gavrović-Jankulović, Marija, "A six-month study of anti-SARS-CoV-2 BNT162b2 mRNA vaccination: A comparative analysis of essential trace elements and anti-RBD IgG sera levels" in Journal of Trace Elements in Medicine and Biology, 74 (2022):127079,
https://doi.org/10.1016/j.jtemb.2022.127079 . .

Efficiency of Natural Deep Eutectic Solvents to Extract Phenolic Compounds from Agrimonia eupatoria: Experimental Study and In Silico Modelling

Lazović, Mila; Cvijetić, Ilija; Jankov, Milica; Milojković-Opsenica, Dušanka; Trifković, Jelena; Ristivojević, Petar

(MDPI, 2022)

TY  - JOUR
AU  - Lazović, Mila
AU  - Cvijetić, Ilija
AU  - Jankov, Milica
AU  - Milojković-Opsenica, Dušanka
AU  - Trifković, Jelena
AU  - Ristivojević, Petar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5637
AB  - To replace common organic solvents that present inherent toxicity and have high volatility and to improve the extraction efficiency, a range of natural deep eutectic solvents (NADESs) were evaluated for the extraction of phenolic compounds from Agrimonia eupatoria. Screening of NADES efficiency was carried out based on the total phenolic and flavonoid content and radical-scavenging activity, determined by spectrophotometry, as well as phenolic compounds quantified, obtained using ultra-high-performance liquid chromatography with a diode array detector and a triple-quadrupole mass spectrometer. Increased extraction efficiency when compared with organic solvent was achieved using NADES mixtures choline chloride (ChCl):urea 1:2 and choline chloride:glycerol 1:1. Flavonol glycosides were the most abundant compounds in all extracts. The COSMO-RS model provided insights into the most important intermolecular interactions that drive the extraction process. Moreover, it could explain the extraction efficiency of flavonol glycosides using ChCl:glycerol NADES. The current article offers experimental evidence and mechanistic insights for the selection of optimal NADES to extract bioactive components from Agrimonia eupatoria. © 2022 by the authors.
PB  - MDPI
T2  - Plants
T1  - Efficiency of Natural Deep Eutectic Solvents to Extract Phenolic Compounds from Agrimonia eupatoria: Experimental Study and In Silico Modelling
VL  - 11
SP  - 2346
DO  - 10.3390/plants11182346
ER  - 
@article{
author = "Lazović, Mila and Cvijetić, Ilija and Jankov, Milica and Milojković-Opsenica, Dušanka and Trifković, Jelena and Ristivojević, Petar",
year = "2022",
abstract = "To replace common organic solvents that present inherent toxicity and have high volatility and to improve the extraction efficiency, a range of natural deep eutectic solvents (NADESs) were evaluated for the extraction of phenolic compounds from Agrimonia eupatoria. Screening of NADES efficiency was carried out based on the total phenolic and flavonoid content and radical-scavenging activity, determined by spectrophotometry, as well as phenolic compounds quantified, obtained using ultra-high-performance liquid chromatography with a diode array detector and a triple-quadrupole mass spectrometer. Increased extraction efficiency when compared with organic solvent was achieved using NADES mixtures choline chloride (ChCl):urea 1:2 and choline chloride:glycerol 1:1. Flavonol glycosides were the most abundant compounds in all extracts. The COSMO-RS model provided insights into the most important intermolecular interactions that drive the extraction process. Moreover, it could explain the extraction efficiency of flavonol glycosides using ChCl:glycerol NADES. The current article offers experimental evidence and mechanistic insights for the selection of optimal NADES to extract bioactive components from Agrimonia eupatoria. © 2022 by the authors.",
publisher = "MDPI",
journal = "Plants",
title = "Efficiency of Natural Deep Eutectic Solvents to Extract Phenolic Compounds from Agrimonia eupatoria: Experimental Study and In Silico Modelling",
volume = "11",
pages = "2346",
doi = "10.3390/plants11182346"
}
Lazović, M., Cvijetić, I., Jankov, M., Milojković-Opsenica, D., Trifković, J.,& Ristivojević, P.. (2022). Efficiency of Natural Deep Eutectic Solvents to Extract Phenolic Compounds from Agrimonia eupatoria: Experimental Study and In Silico Modelling. in Plants
MDPI., 11, 2346.
https://doi.org/10.3390/plants11182346
Lazović M, Cvijetić I, Jankov M, Milojković-Opsenica D, Trifković J, Ristivojević P. Efficiency of Natural Deep Eutectic Solvents to Extract Phenolic Compounds from Agrimonia eupatoria: Experimental Study and In Silico Modelling. in Plants. 2022;11:2346.
doi:10.3390/plants11182346 .
Lazović, Mila, Cvijetić, Ilija, Jankov, Milica, Milojković-Opsenica, Dušanka, Trifković, Jelena, Ristivojević, Petar, "Efficiency of Natural Deep Eutectic Solvents to Extract Phenolic Compounds from Agrimonia eupatoria: Experimental Study and In Silico Modelling" in Plants, 11 (2022):2346,
https://doi.org/10.3390/plants11182346 . .

Water: new aspect of hydrogen bonding in the solid state

Milovanović, Milan R.; Stanković, Ivana M.; Živković, Jelena M.; Ninković, Dragan B.; Hall, Michael B.; Zarić, Snežana D; Macgillivray, L. R.

(International Union of Crystallography, 2022)

TY  - JOUR
AU  - Milovanović, Milan R.
AU  - Stanković, Ivana M.
AU  - Živković, Jelena M.
AU  - Ninković, Dragan B.
AU  - Hall, Michael B.
AU  - Zarić, Snežana D
AU  - Macgillivray, L. R.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5638
AB  - All water-water contacts in the crystal structures from the Cambridge Structural Database with d OO ≤ 4.0 Å have been found. These contacts were analysed on the basis of their geometries and interaction energies from CCSD(T)/CBS calculations. The results show 6729 attractive water-water contacts, of which 4717 are classical hydrogen bonds (d OH ≤ 3.0 Å and α ≥ 120°) with most being stronger than -3.3 kcal mol-1. Beyond the region of these hydrogen bonds, there is a large number of attractive interactions (2062). The majority are antiparallel dipolar interactions, where the O - H bonds of two water molecules lying in parallel planes are oriented antiparallel to each other. Developing geometric criteria for these antiparallel dipoles (β1, β2 ≥ 160°, 80 ≤ α ≤ 140° and T HOHO > 40°) yielded 1282 attractive contacts. The interaction energies of these antiparallel oriented water molecules are up to -4.7 kcal mol-1, while most of the contacts have interaction energies in the range -0.9 to -2.1 kcal mol-1. This study suggests that the geometric criteria for defining attractive water-water interactions should be broader than the classical hydrogen-bonding criteria, a change that may reveal undiscovered and unappreciated interactions controlling molecular structure and chemistry. © 2022 Milan R. Milovanović et al.
PB  - International Union of Crystallography
T2  - IUCrJ
T1  - Water: new aspect of hydrogen bonding in the solid state
VL  - 9
IS  - 5
DO  - 10.1107/S2052252522006728
ER  - 
@article{
author = "Milovanović, Milan R. and Stanković, Ivana M. and Živković, Jelena M. and Ninković, Dragan B. and Hall, Michael B. and Zarić, Snežana D and Macgillivray, L. R.",
year = "2022",
abstract = "All water-water contacts in the crystal structures from the Cambridge Structural Database with d OO ≤ 4.0 Å have been found. These contacts were analysed on the basis of their geometries and interaction energies from CCSD(T)/CBS calculations. The results show 6729 attractive water-water contacts, of which 4717 are classical hydrogen bonds (d OH ≤ 3.0 Å and α ≥ 120°) with most being stronger than -3.3 kcal mol-1. Beyond the region of these hydrogen bonds, there is a large number of attractive interactions (2062). The majority are antiparallel dipolar interactions, where the O - H bonds of two water molecules lying in parallel planes are oriented antiparallel to each other. Developing geometric criteria for these antiparallel dipoles (β1, β2 ≥ 160°, 80 ≤ α ≤ 140° and T HOHO > 40°) yielded 1282 attractive contacts. The interaction energies of these antiparallel oriented water molecules are up to -4.7 kcal mol-1, while most of the contacts have interaction energies in the range -0.9 to -2.1 kcal mol-1. This study suggests that the geometric criteria for defining attractive water-water interactions should be broader than the classical hydrogen-bonding criteria, a change that may reveal undiscovered and unappreciated interactions controlling molecular structure and chemistry. © 2022 Milan R. Milovanović et al.",
publisher = "International Union of Crystallography",
journal = "IUCrJ",
title = "Water: new aspect of hydrogen bonding in the solid state",
volume = "9",
number = "5",
doi = "10.1107/S2052252522006728"
}
Milovanović, M. R., Stanković, I. M., Živković, J. M., Ninković, D. B., Hall, M. B., Zarić, S. D.,& Macgillivray, L. R.. (2022). Water: new aspect of hydrogen bonding in the solid state. in IUCrJ
International Union of Crystallography., 9(5).
https://doi.org/10.1107/S2052252522006728
Milovanović MR, Stanković IM, Živković JM, Ninković DB, Hall MB, Zarić SD, Macgillivray LR. Water: new aspect of hydrogen bonding in the solid state. in IUCrJ. 2022;9(5).
doi:10.1107/S2052252522006728 .
Milovanović, Milan R., Stanković, Ivana M., Živković, Jelena M., Ninković, Dragan B., Hall, Michael B., Zarić, Snežana D, Macgillivray, L. R., "Water: new aspect of hydrogen bonding in the solid state" in IUCrJ, 9, no. 5 (2022),
https://doi.org/10.1107/S2052252522006728 . .

Aromaticity study of singlet- and triplet-state corannulene dianion and dication

Aleksić, Jovana; Stojanović, Milovan; Baranac-Stojanović, Marija

(Wiley, 2022)

TY  - JOUR
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Baranac-Stojanović, Marija
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5626
AB  - Aromaticity rules in the ground singlet state and the first excited triplet state are exactly opposite, as shown by Baird. Thus, (4n + 2)π electron annulenes are antiaromatic and 4nπ annulenes are aromatic in their triplet state. In this work, we employ quantum-mechanical calculations at the density functional theory (DFT) level to examine (anti)aromaticity of singlet and triplet corannulene dianion and dication in their bowl-shaped ground-state structure and planar transition-state structure. We find that singlet dianion contains aromatic hub and antiaromatic rim, whereas singlet dication is an antiaromatic system. This agrees with previous calculations of current density induced by perpendicular magnetic field. For triplet dianion, we find that it can be described as having aromatic rim and nonaromatic hub. Triplet dication was found to be nonaromatic, though in planar transition-state structure, locally and semiglobally antiaromatic naphthalene subunit and aromatic central ring can be discerned. © 2022 John Wiley & Sons Ltd.
PB  - Wiley
T2  - Journal of Physical Organic Chemistry
T1  - Aromaticity study of singlet- and triplet-state corannulene dianion and dication
VL  - n/a
DO  - 10.1002/poc.4434
ER  - 
@article{
author = "Aleksić, Jovana and Stojanović, Milovan and Baranac-Stojanović, Marija",
year = "2022",
abstract = "Aromaticity rules in the ground singlet state and the first excited triplet state are exactly opposite, as shown by Baird. Thus, (4n + 2)π electron annulenes are antiaromatic and 4nπ annulenes are aromatic in their triplet state. In this work, we employ quantum-mechanical calculations at the density functional theory (DFT) level to examine (anti)aromaticity of singlet and triplet corannulene dianion and dication in their bowl-shaped ground-state structure and planar transition-state structure. We find that singlet dianion contains aromatic hub and antiaromatic rim, whereas singlet dication is an antiaromatic system. This agrees with previous calculations of current density induced by perpendicular magnetic field. For triplet dianion, we find that it can be described as having aromatic rim and nonaromatic hub. Triplet dication was found to be nonaromatic, though in planar transition-state structure, locally and semiglobally antiaromatic naphthalene subunit and aromatic central ring can be discerned. © 2022 John Wiley & Sons Ltd.",
publisher = "Wiley",
journal = "Journal of Physical Organic Chemistry",
title = "Aromaticity study of singlet- and triplet-state corannulene dianion and dication",
volume = "n/a",
doi = "10.1002/poc.4434"
}
Aleksić, J., Stojanović, M.,& Baranac-Stojanović, M.. (2022). Aromaticity study of singlet- and triplet-state corannulene dianion and dication. in Journal of Physical Organic Chemistry
Wiley., n/a.
https://doi.org/10.1002/poc.4434
Aleksić J, Stojanović M, Baranac-Stojanović M. Aromaticity study of singlet- and triplet-state corannulene dianion and dication. in Journal of Physical Organic Chemistry. 2022;n/a.
doi:10.1002/poc.4434 .
Aleksić, Jovana, Stojanović, Milovan, Baranac-Stojanović, Marija, "Aromaticity study of singlet- and triplet-state corannulene dianion and dication" in Journal of Physical Organic Chemistry, n/a (2022),
https://doi.org/10.1002/poc.4434 . .

La(OH)3 Multi-Walled Carbon Nanotube/Carbon Paste-Based Sensing Approach for the Detection of Uric Acid—A Product of Environmentally Stressed Cells

Knežević, Sara; Ognjanović, Miloš; Stanković, Vesna; Zlatanova, Milena; Nešić, Andrijana; Gavrović-Jankulović, Marija; Stanković, Dalibor

(MDPI, 2022)

TY  - JOUR
AU  - Knežević, Sara
AU  - Ognjanović, Miloš
AU  - Stanković, Vesna
AU  - Zlatanova, Milena
AU  - Nešić, Andrijana
AU  - Gavrović-Jankulović, Marija
AU  - Stanković, Dalibor
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5622
AB  - This paper aims to develop an amperometric, non-enzymatic sensor for detecting and quantifying UA as an alert signal induced by allergens with protease activity in human cell lines (HEK293 and HeLa). Uric acid (UA) has been classified as a damage-associated molecular pattern (DAMP) molecule that serves a physiological purpose inside the cell, while outside the cell it can be an indicator of cell damage. Cell damage or stress can be caused by different health problems or by environmental irritants, such as allergens. We can act and prevent the events that generate stress by determining the extent to which cells are under stress. Amperometric calibration measurements were performed with a carbon paste electrode modified with La(OH)3@MWCNT, at the potential of 0.3 V. The calibration curve was constructed in a linear operating range from 0.67 μM to 121 μM UA. The proposed sensor displayed good reproducibility with an RSD of 3.65% calculated for five subsequent measurements, and a low detection limit of 64.28 nM, determined using the 3 S/m method. Interference studies and the real sample analysis of allergen-treated cell lines proved that the proposed sensing platform possesses excellent sensitivity, reproducibility, and stability. Therefore, it can potentially be used to evaluate stress factors in medical research and clinical practice.
PB  - MDPI
T2  - Biosensors
T1  - La(OH)3 Multi-Walled Carbon Nanotube/Carbon Paste-Based Sensing Approach for the Detection of Uric Acid—A Product of Environmentally Stressed Cells
VL  - 12
IS  - 9
SP  - 705
DO  - 10.3390/bios12090705
ER  - 
@article{
author = "Knežević, Sara and Ognjanović, Miloš and Stanković, Vesna and Zlatanova, Milena and Nešić, Andrijana and Gavrović-Jankulović, Marija and Stanković, Dalibor",
year = "2022",
abstract = "This paper aims to develop an amperometric, non-enzymatic sensor for detecting and quantifying UA as an alert signal induced by allergens with protease activity in human cell lines (HEK293 and HeLa). Uric acid (UA) has been classified as a damage-associated molecular pattern (DAMP) molecule that serves a physiological purpose inside the cell, while outside the cell it can be an indicator of cell damage. Cell damage or stress can be caused by different health problems or by environmental irritants, such as allergens. We can act and prevent the events that generate stress by determining the extent to which cells are under stress. Amperometric calibration measurements were performed with a carbon paste electrode modified with La(OH)3@MWCNT, at the potential of 0.3 V. The calibration curve was constructed in a linear operating range from 0.67 μM to 121 μM UA. The proposed sensor displayed good reproducibility with an RSD of 3.65% calculated for five subsequent measurements, and a low detection limit of 64.28 nM, determined using the 3 S/m method. Interference studies and the real sample analysis of allergen-treated cell lines proved that the proposed sensing platform possesses excellent sensitivity, reproducibility, and stability. Therefore, it can potentially be used to evaluate stress factors in medical research and clinical practice.",
publisher = "MDPI",
journal = "Biosensors",
title = "La(OH)3 Multi-Walled Carbon Nanotube/Carbon Paste-Based Sensing Approach for the Detection of Uric Acid—A Product of Environmentally Stressed Cells",
volume = "12",
number = "9",
pages = "705",
doi = "10.3390/bios12090705"
}
Knežević, S., Ognjanović, M., Stanković, V., Zlatanova, M., Nešić, A., Gavrović-Jankulović, M.,& Stanković, D.. (2022). La(OH)3 Multi-Walled Carbon Nanotube/Carbon Paste-Based Sensing Approach for the Detection of Uric Acid—A Product of Environmentally Stressed Cells. in Biosensors
MDPI., 12(9), 705.
https://doi.org/10.3390/bios12090705
Knežević S, Ognjanović M, Stanković V, Zlatanova M, Nešić A, Gavrović-Jankulović M, Stanković D. La(OH)3 Multi-Walled Carbon Nanotube/Carbon Paste-Based Sensing Approach for the Detection of Uric Acid—A Product of Environmentally Stressed Cells. in Biosensors. 2022;12(9):705.
doi:10.3390/bios12090705 .
Knežević, Sara, Ognjanović, Miloš, Stanković, Vesna, Zlatanova, Milena, Nešić, Andrijana, Gavrović-Jankulović, Marija, Stanković, Dalibor, "La(OH)3 Multi-Walled Carbon Nanotube/Carbon Paste-Based Sensing Approach for the Detection of Uric Acid—A Product of Environmentally Stressed Cells" in Biosensors, 12, no. 9 (2022):705,
https://doi.org/10.3390/bios12090705 . .
1

NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort

Simić, Katarina; Todorović, Nina; Trifunović, Snežana S.; Miladinović, Zoran; Gavrilović, Aleksandra; Jovanović, Silvana; Avramović, Nataša; Gođevac, Dejan; Vujisić, Ljubodrag V.; Tešević, Vele; Tasić, Ljubica; Mandić, Boris

(MDPI, 2022)

TY  - JOUR
AU  - Simić, Katarina
AU  - Todorović, Nina
AU  - Trifunović, Snežana S.
AU  - Miladinović, Zoran
AU  - Gavrilović, Aleksandra
AU  - Jovanović, Silvana
AU  - Avramović, Nataša
AU  - Gođevac, Dejan
AU  - Vujisić, Ljubodrag V.
AU  - Tešević, Vele
AU  - Tasić, Ljubica
AU  - Mandić, Boris
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5613
AB  - Schizophrenia is a widespread mental disorder that leads to significant functional impairments and premature death. The state of the art indicates gaps in the understanding and diagnosis of this disease, but also the need for personalized and precise approaches to patients through customized medical treatment and reliable monitoring of treatment response. In order to fulfill existing gaps, the establishment of a universal set of disorder biomarkers is a necessary step. Metabolomic investigations of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39), based on NMR analyses associated with chemometrics, led to the identification of 26 metabolites/biomarkers for this disorder. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) models with prediction accuracies of 0.9718 and higher were accomplished during chemometric analysis. The established biomarker set includes aspartate/aspartic acid, lysine, 2-hydroxybutyric acid, and acylglycerols, which are identified for the first time in schizophrenia serum samples by NMR experiments. The other 22 identified metabolites in the Serbian samples are in accordance with the previously established NMR-based serum biomarker sets of Brazilian and/or Chinese patient samples. Thirteen metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) that are common for three different ethnic and geographic origins (Serbia, Brazil and China) could be a good start point for the setup of a universal NMR serum biomarker set for schizophrenia. © 2022 by the authors.
PB  - MDPI
T2  - Metabolites
T1  - NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort
VL  - 12
IS  - 8
SP  - 707
DO  - 10.3390/metabo12080707
ER  - 
@article{
author = "Simić, Katarina and Todorović, Nina and Trifunović, Snežana S. and Miladinović, Zoran and Gavrilović, Aleksandra and Jovanović, Silvana and Avramović, Nataša and Gođevac, Dejan and Vujisić, Ljubodrag V. and Tešević, Vele and Tasić, Ljubica and Mandić, Boris",
year = "2022",
abstract = "Schizophrenia is a widespread mental disorder that leads to significant functional impairments and premature death. The state of the art indicates gaps in the understanding and diagnosis of this disease, but also the need for personalized and precise approaches to patients through customized medical treatment and reliable monitoring of treatment response. In order to fulfill existing gaps, the establishment of a universal set of disorder biomarkers is a necessary step. Metabolomic investigations of serum samples of Serbian patients with schizophrenia (51) and healthy controls (39), based on NMR analyses associated with chemometrics, led to the identification of 26 metabolites/biomarkers for this disorder. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) models with prediction accuracies of 0.9718 and higher were accomplished during chemometric analysis. The established biomarker set includes aspartate/aspartic acid, lysine, 2-hydroxybutyric acid, and acylglycerols, which are identified for the first time in schizophrenia serum samples by NMR experiments. The other 22 identified metabolites in the Serbian samples are in accordance with the previously established NMR-based serum biomarker sets of Brazilian and/or Chinese patient samples. Thirteen metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) that are common for three different ethnic and geographic origins (Serbia, Brazil and China) could be a good start point for the setup of a universal NMR serum biomarker set for schizophrenia. © 2022 by the authors.",
publisher = "MDPI",
journal = "Metabolites",
title = "NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort",
volume = "12",
number = "8",
pages = "707",
doi = "10.3390/metabo12080707"
}
Simić, K., Todorović, N., Trifunović, S. S., Miladinović, Z., Gavrilović, A., Jovanović, S., Avramović, N., Gođevac, D., Vujisić, L. V., Tešević, V., Tasić, L.,& Mandić, B.. (2022). NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort. in Metabolites
MDPI., 12(8), 707.
https://doi.org/10.3390/metabo12080707
Simić K, Todorović N, Trifunović SS, Miladinović Z, Gavrilović A, Jovanović S, Avramović N, Gođevac D, Vujisić LV, Tešević V, Tasić L, Mandić B. NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort. in Metabolites. 2022;12(8):707.
doi:10.3390/metabo12080707 .
Simić, Katarina, Todorović, Nina, Trifunović, Snežana S., Miladinović, Zoran, Gavrilović, Aleksandra, Jovanović, Silvana, Avramović, Nataša, Gođevac, Dejan, Vujisić, Ljubodrag V., Tešević, Vele, Tasić, Ljubica, Mandić, Boris, "NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort" in Metabolites, 12, no. 8 (2022):707,
https://doi.org/10.3390/metabo12080707 . .

Iron salt-promoted oxidation of steroidal phenols by m -chloroperbenzoic acid: a route to possible antitumor agents

Kop, Tatjana J.; Terzić-Jovanović, Nataša; Žižak, Željko; Šolaja, Bogdan A.; Milić, Dragana R.

(Royal Society of Chemistry, 2022)

TY  - JOUR
AU  - Kop, Tatjana J.
AU  - Terzić-Jovanović, Nataša
AU  - Žižak, Željko
AU  - Šolaja, Bogdan A.
AU  - Milić, Dragana R.
PY  - 2022
UR  - https://pubs.rsc.org/en/content/articlelanding/2022/ra/d2ra03717c
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5523
AB  - Iron salt-promoted reaction of estrone and its derivatives with              meta              -chloroperoxybenzoic acid was developed and epoxyquinols were further transformed. Most compounds showed              in vitro              antiproliferative activity.                      ,                           A new oxidant, containing              m              -chloroperoxybenzoic acid (MCPBA) and an iron salt, was developed and used for oxidation of steroidal phenols to a quinol/epoxyquinol mixture. Reaction was optimized for estrone, by varying initiators (Fe-salts), reaction temperature, time and mode of MCPBA application. A series of five more substrates (17β-estradiol and its hydrophobized derivatives) was subjected to the optimized oxidation, providing corresponding              p              -quinols and 4β,5β-epoxyquinols in good to moderate yields. The obtained epoxyquinols were additionally transformed by oxidation, as well as the acid-catalyzed oxirane opening. In a preliminary study of the antiproliferative activity against human cancer cell lines, all newly synthesized compounds expressed moderate to high activity.
PB  - Royal Society of Chemistry
T2  - RSC AdvancesRSC Adv.
T1  - Iron salt-promoted oxidation of steroidal phenols by m -chloroperbenzoic acid: a route to possible antitumor agents
VL  - 12
IS  - 32
SP  - 20649
EP  - 20655
DO  - 10.1039/D2RA03717C
ER  - 
@article{
author = "Kop, Tatjana J. and Terzić-Jovanović, Nataša and Žižak, Željko and Šolaja, Bogdan A. and Milić, Dragana R.",
year = "2022",
abstract = "Iron salt-promoted reaction of estrone and its derivatives with              meta              -chloroperoxybenzoic acid was developed and epoxyquinols were further transformed. Most compounds showed              in vitro              antiproliferative activity.                      ,                           A new oxidant, containing              m              -chloroperoxybenzoic acid (MCPBA) and an iron salt, was developed and used for oxidation of steroidal phenols to a quinol/epoxyquinol mixture. Reaction was optimized for estrone, by varying initiators (Fe-salts), reaction temperature, time and mode of MCPBA application. A series of five more substrates (17β-estradiol and its hydrophobized derivatives) was subjected to the optimized oxidation, providing corresponding              p              -quinols and 4β,5β-epoxyquinols in good to moderate yields. The obtained epoxyquinols were additionally transformed by oxidation, as well as the acid-catalyzed oxirane opening. In a preliminary study of the antiproliferative activity against human cancer cell lines, all newly synthesized compounds expressed moderate to high activity.",
publisher = "Royal Society of Chemistry",
journal = "RSC AdvancesRSC Adv.",
title = "Iron salt-promoted oxidation of steroidal phenols by m -chloroperbenzoic acid: a route to possible antitumor agents",
volume = "12",
number = "32",
pages = "20649-20655",
doi = "10.1039/D2RA03717C"
}
Kop, T. J., Terzić-Jovanović, N., Žižak, Ž., Šolaja, B. A.,& Milić, D. R.. (2022). Iron salt-promoted oxidation of steroidal phenols by m -chloroperbenzoic acid: a route to possible antitumor agents. in RSC AdvancesRSC Adv.
Royal Society of Chemistry., 12(32), 20649-20655.
https://doi.org/10.1039/D2RA03717C
Kop TJ, Terzić-Jovanović N, Žižak Ž, Šolaja BA, Milić DR. Iron salt-promoted oxidation of steroidal phenols by m -chloroperbenzoic acid: a route to possible antitumor agents. in RSC AdvancesRSC Adv.. 2022;12(32):20649-20655.
doi:10.1039/D2RA03717C .
Kop, Tatjana J., Terzić-Jovanović, Nataša, Žižak, Željko, Šolaja, Bogdan A., Milić, Dragana R., "Iron salt-promoted oxidation of steroidal phenols by m -chloroperbenzoic acid: a route to possible antitumor agents" in RSC AdvancesRSC Adv., 12, no. 32 (2022):20649-20655,
https://doi.org/10.1039/D2RA03717C . .

Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites

Šuljagić, Marija; Milenković, Milica; Uskoković, Vuk; Mirković, Miljana; Vrbica, Boško; Pavlović, Vladimir D.; Živković-Radovanović, Vukosava; Stanković, Dalibor; Andjelković, Ljubica

(Elsevier, 2022)

TY  - JOUR
AU  - Šuljagić, Marija
AU  - Milenković, Milica
AU  - Uskoković, Vuk
AU  - Mirković, Miljana
AU  - Vrbica, Boško
AU  - Pavlović, Vladimir D.
AU  - Živković-Radovanović, Vukosava
AU  - Stanković, Dalibor
AU  - Andjelković, Ljubica
PY  - 2022
UR  - https://www.sciencedirect.com/journal/materials-today-communications
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5521
AB  - The emerging threat of bacterial resistance to antibiotics prompts the urgent search for biomaterials for the treatment of infectious disease. Here we report on the synthesis and characterization of a multiphasic nanocomposite comprising magnetic iron oxide and silver nanoparticles. The method of synthesis involved the combustion of a metalorganic complex and reduction of the silver ions that were exchanged and/or adsorbed on the surface of iron oxide. Different physical and chemical treatments coupled to the reduction process, including ultrasound and Lugol's iodine solution, respectively, homogenized the distribution of the silver nanoparticles on the iron oxide phase. Remarkably, using ascorbic acid as a reductant enhanced the magnetic properties of the material as a result of the reduction of the magnetic matrix alongside the silver cations. The treatment with ultrasound detached large amounts of silver from the iron oxide phase and resulted in the lowest amount of silver incorporated in the nanocomposite. Despite that, this treatment led to the highest antibacterial activity against both Gram-positive and Gram-negative strains, indicating that the homogeneity of the distribution of silver on the iron oxide matrix is a more important determinant of the antibacterial performance than the amount of silver incorporated in the material. At the same time, the treatment with Lugol's iodine equally increased the distribution homogeneity, but induced excessive ion exchange and crystal lattice substitutions, thereby adversely affecting the antibacterial performance. This has indicated that the mode of binding silver to iron oxide can compensate for the positive effects of homogeneous distribution with respect to the antibacterial performance.
PB  - Elsevier
T2  - Materials Today Communications
T1  - Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites
VL  - 32
SP  - 104157
DO  - 10.1016/j.mtcomm.2022.104157
ER  - 
@article{
author = "Šuljagić, Marija and Milenković, Milica and Uskoković, Vuk and Mirković, Miljana and Vrbica, Boško and Pavlović, Vladimir D. and Živković-Radovanović, Vukosava and Stanković, Dalibor and Andjelković, Ljubica",
year = "2022",
abstract = "The emerging threat of bacterial resistance to antibiotics prompts the urgent search for biomaterials for the treatment of infectious disease. Here we report on the synthesis and characterization of a multiphasic nanocomposite comprising magnetic iron oxide and silver nanoparticles. The method of synthesis involved the combustion of a metalorganic complex and reduction of the silver ions that were exchanged and/or adsorbed on the surface of iron oxide. Different physical and chemical treatments coupled to the reduction process, including ultrasound and Lugol's iodine solution, respectively, homogenized the distribution of the silver nanoparticles on the iron oxide phase. Remarkably, using ascorbic acid as a reductant enhanced the magnetic properties of the material as a result of the reduction of the magnetic matrix alongside the silver cations. The treatment with ultrasound detached large amounts of silver from the iron oxide phase and resulted in the lowest amount of silver incorporated in the nanocomposite. Despite that, this treatment led to the highest antibacterial activity against both Gram-positive and Gram-negative strains, indicating that the homogeneity of the distribution of silver on the iron oxide matrix is a more important determinant of the antibacterial performance than the amount of silver incorporated in the material. At the same time, the treatment with Lugol's iodine equally increased the distribution homogeneity, but induced excessive ion exchange and crystal lattice substitutions, thereby adversely affecting the antibacterial performance. This has indicated that the mode of binding silver to iron oxide can compensate for the positive effects of homogeneous distribution with respect to the antibacterial performance.",
publisher = "Elsevier",
journal = "Materials Today Communications",
title = "Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites",
volume = "32",
pages = "104157",
doi = "10.1016/j.mtcomm.2022.104157"
}
Šuljagić, M., Milenković, M., Uskoković, V., Mirković, M., Vrbica, B., Pavlović, V. D., Živković-Radovanović, V., Stanković, D.,& Andjelković, L.. (2022). Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites. in Materials Today Communications
Elsevier., 32, 104157.
https://doi.org/10.1016/j.mtcomm.2022.104157
Šuljagić M, Milenković M, Uskoković V, Mirković M, Vrbica B, Pavlović VD, Živković-Radovanović V, Stanković D, Andjelković L. Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites. in Materials Today Communications. 2022;32:104157.
doi:10.1016/j.mtcomm.2022.104157 .
Šuljagić, Marija, Milenković, Milica, Uskoković, Vuk, Mirković, Miljana, Vrbica, Boško, Pavlović, Vladimir D., Živković-Radovanović, Vukosava, Stanković, Dalibor, Andjelković, Ljubica, "Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites" in Materials Today Communications, 32 (2022):104157,
https://doi.org/10.1016/j.mtcomm.2022.104157 . .

Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production

Stojanović, Sanja; Ristović, Marina; Stepanović, Jelena; Margetić, Aleksandra; Duduk, Bojan; Vujčić, Zoran; Dojnov, Biljana

(Elsevier, 2022)

TY  - JOUR
AU  - Stojanović, Sanja
AU  - Ristović, Marina
AU  - Stepanović, Jelena
AU  - Margetić, Aleksandra
AU  - Duduk, Bojan
AU  - Vujčić, Zoran
AU  - Dojnov, Biljana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5517
AB  - Production of fructooligosaccharides (FOS) is a trending topic due to their prebiotic effect becoming increasingly important for the modern human diet. The most suitable process for FOS production is the one using fungal inulinases. Introduction of new fungal inulinase producers and their implementation in production of inulinase enzymes is therefore gaining interest. This study provides a new approach to FOS synthesis by fungal enzyme complex without prior separation of any specific enzyme. Inulinase enzyme complexes could be used for the synthesis of FOS in two possible ways – hydrolysis of inulin (FOSh) and transfructosylation process of sucrose (FOSs), as demonstrated here. Depending on the fungal growth inducing substrate, a variety of inulinase enzyme complexes was obtained – one of which was most successful in production of FOSh and another one of FOSs. Substrates derived from crops: triticale, wheat bran, Jerusalem artichoke and Aspergillus welwitschiae isolate, previously proven as safe for use in food, were utilized for production of inulinase enzyme cocktails. The highest FOSs production was obtained by enzyme complex rich in β-fructofuranosidase, while the highest FOSh production was obtained by enzyme complex rich in endoinulinase. Both FOSh and FOSs showed antioxidant potential according to ABTS and ORAC, which classifies them as a suitable additive in functional food. Simultaneous zymographic detection of inulinase enzymes, which could contribute to expansion of the knowledge on fungal enzymes, was developed and applied here. It demonstrated the presence of different inulinase isoforms depending on fungal growth substrate. These findings, which rely on the innate ability of fungi to co-produce all inulinases from a cocktail, could be useful as a new, easy approach to FOS production by fungal enzymes without their separation and purification, contributing to cheaper and faster production processes.
PB  - Elsevier
T2  - Food Research International
T2  - Food Research International
T1  - Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production
VL  - 160
DO  - 10.1016/j.foodres.2022.111755
ER  - 
@article{
author = "Stojanović, Sanja and Ristović, Marina and Stepanović, Jelena and Margetić, Aleksandra and Duduk, Bojan and Vujčić, Zoran and Dojnov, Biljana",
year = "2022",
abstract = "Production of fructooligosaccharides (FOS) is a trending topic due to their prebiotic effect becoming increasingly important for the modern human diet. The most suitable process for FOS production is the one using fungal inulinases. Introduction of new fungal inulinase producers and their implementation in production of inulinase enzymes is therefore gaining interest. This study provides a new approach to FOS synthesis by fungal enzyme complex without prior separation of any specific enzyme. Inulinase enzyme complexes could be used for the synthesis of FOS in two possible ways – hydrolysis of inulin (FOSh) and transfructosylation process of sucrose (FOSs), as demonstrated here. Depending on the fungal growth inducing substrate, a variety of inulinase enzyme complexes was obtained – one of which was most successful in production of FOSh and another one of FOSs. Substrates derived from crops: triticale, wheat bran, Jerusalem artichoke and Aspergillus welwitschiae isolate, previously proven as safe for use in food, were utilized for production of inulinase enzyme cocktails. The highest FOSs production was obtained by enzyme complex rich in β-fructofuranosidase, while the highest FOSh production was obtained by enzyme complex rich in endoinulinase. Both FOSh and FOSs showed antioxidant potential according to ABTS and ORAC, which classifies them as a suitable additive in functional food. Simultaneous zymographic detection of inulinase enzymes, which could contribute to expansion of the knowledge on fungal enzymes, was developed and applied here. It demonstrated the presence of different inulinase isoforms depending on fungal growth substrate. These findings, which rely on the innate ability of fungi to co-produce all inulinases from a cocktail, could be useful as a new, easy approach to FOS production by fungal enzymes without their separation and purification, contributing to cheaper and faster production processes.",
publisher = "Elsevier",
journal = "Food Research International, Food Research International",
title = "Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production",
volume = "160",
doi = "10.1016/j.foodres.2022.111755"
}
Stojanović, S., Ristović, M., Stepanović, J., Margetić, A., Duduk, B., Vujčić, Z.,& Dojnov, B.. (2022). Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production. in Food Research International
Elsevier., 160.
https://doi.org/10.1016/j.foodres.2022.111755
Stojanović S, Ristović M, Stepanović J, Margetić A, Duduk B, Vujčić Z, Dojnov B. Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production. in Food Research International. 2022;160.
doi:10.1016/j.foodres.2022.111755 .
Stojanović, Sanja, Ristović, Marina, Stepanović, Jelena, Margetić, Aleksandra, Duduk, Bojan, Vujčić, Zoran, Dojnov, Biljana, "Aspergillus welwitschiae inulinase enzyme cocktails obtained on agro-material inducers for the purpose of fructooligosaccharides production" in Food Research International, 160 (2022),
https://doi.org/10.1016/j.foodres.2022.111755 . .
1

Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types

Mikavica, Ivana; Ranđelović, Dragana; Đorđević, Vladan; Rakić, Tamara; Gajić, Gordana; Mutić, Jelena

(2022)

TY  - JOUR
AU  - Mikavica, Ivana
AU  - Ranđelović, Dragana
AU  - Đorđević, Vladan
AU  - Rakić, Tamara
AU  - Gajić, Gordana
AU  - Mutić, Jelena
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5516
AB  - The mobility of chemical elements in the soil-orchid system has been poorly studied. The aim of this study is to evaluate the uptake and mobility of several trace (Li, Ba, Sr, Ag, Hg, and B) and macronutrients (Ca, Mg, and K) in the orchid Anacamptis morio (L.) R.M.Bateman, Pridgeon & M.W.Chase from soils in western Serbia. The sampling sites are characterized by three different bedrock types—cherts, limestones, and serpentines, which are the source of the significant chemical differences in the elemental status of the soil and plant tissues. The four-step Community Bureau of Reference sequential extraction procedure was used to determine the distribution of fractions and predict their potential phytoavailability. The orchid and soil samples were analyzed for total elemental content analysis using ICP-OES. The greatest potential for plant availability was determined for Ba and Sr, representing about 80% of the total soil content. More than 40% of Li in the soils was found to be potentially phytoavailable. Significant correlations were found between the total content of Li, B, and Sr in soils. Between 38 and 60% of Li content and more than 80% of Ba and Sr content were determined to be potentially phytoavailable by sequential analysis. The highest bioconcentration factor (> 1) was determined in the case of B and Sr for all orchid organs, while translocation factor for Li was highest in tubers and leaves. The studied elements were mainly stored in tubers and roots, indicating the exclusion strategy of A. morio as a metal tolerance mechanism. The data obtained showed significant differences in metal content in soils and plants originating from sites with different parent materials, suggesting that bedrock type and associated soil properties are important factors that determine chemical element mobility and uptake.
T2  - Environmental Science and Pollution Research
T2  - Environmental Science and Pollution Research
T1  - Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types
VL  - n/a
DO  - 10.1007/s11356-022-22110-z
ER  - 
@article{
author = "Mikavica, Ivana and Ranđelović, Dragana and Đorđević, Vladan and Rakić, Tamara and Gajić, Gordana and Mutić, Jelena",
year = "2022",
abstract = "The mobility of chemical elements in the soil-orchid system has been poorly studied. The aim of this study is to evaluate the uptake and mobility of several trace (Li, Ba, Sr, Ag, Hg, and B) and macronutrients (Ca, Mg, and K) in the orchid Anacamptis morio (L.) R.M.Bateman, Pridgeon & M.W.Chase from soils in western Serbia. The sampling sites are characterized by three different bedrock types—cherts, limestones, and serpentines, which are the source of the significant chemical differences in the elemental status of the soil and plant tissues. The four-step Community Bureau of Reference sequential extraction procedure was used to determine the distribution of fractions and predict their potential phytoavailability. The orchid and soil samples were analyzed for total elemental content analysis using ICP-OES. The greatest potential for plant availability was determined for Ba and Sr, representing about 80% of the total soil content. More than 40% of Li in the soils was found to be potentially phytoavailable. Significant correlations were found between the total content of Li, B, and Sr in soils. Between 38 and 60% of Li content and more than 80% of Ba and Sr content were determined to be potentially phytoavailable by sequential analysis. The highest bioconcentration factor (> 1) was determined in the case of B and Sr for all orchid organs, while translocation factor for Li was highest in tubers and leaves. The studied elements were mainly stored in tubers and roots, indicating the exclusion strategy of A. morio as a metal tolerance mechanism. The data obtained showed significant differences in metal content in soils and plants originating from sites with different parent materials, suggesting that bedrock type and associated soil properties are important factors that determine chemical element mobility and uptake.",
journal = "Environmental Science and Pollution Research, Environmental Science and Pollution Research",
title = "Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types",
volume = "n/a",
doi = "10.1007/s11356-022-22110-z"
}
Mikavica, I., Ranđelović, D., Đorđević, V., Rakić, T., Gajić, G.,& Mutić, J.. (2022). Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types. in Environmental Science and Pollution Research, n/a.
https://doi.org/10.1007/s11356-022-22110-z
Mikavica I, Ranđelović D, Đorđević V, Rakić T, Gajić G, Mutić J. Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types. in Environmental Science and Pollution Research. 2022;n/a.
doi:10.1007/s11356-022-22110-z .
Mikavica, Ivana, Ranđelović, Dragana, Đorđević, Vladan, Rakić, Tamara, Gajić, Gordana, Mutić, Jelena, "Concentration and mobility of trace elements (Li, Ba, Sr, Ag, Hg, B) and macronutrients (Ca, Mg, K) in soil-orchid system on different bedrock types" in Environmental Science and Pollution Research, n/a (2022),
https://doi.org/10.1007/s11356-022-22110-z . .

Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins

Vitomirov, Teodora; Dimiza, Filitsa; Matić, Ivana Z.; Stanojković, Tatjana; Pirković, Andrea; Živković, Lada; Spremo-Potparević, Biljana; Novaković, Irena; Anđelković, Katarina; Milčić, Miloš; Psomas, George; Ristović, Maja Šumar

(Elsevier, 2022)

TY  - JOUR
AU  - Vitomirov, Teodora
AU  - Dimiza, Filitsa
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana
AU  - Pirković, Andrea
AU  - Živković, Lada
AU  - Spremo-Potparević, Biljana
AU  - Novaković, Irena
AU  - Anđelković, Katarina
AU  - Milčić, Miloš
AU  - Psomas, George
AU  - Ristović, Maja Šumar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5515
AB  - In this article, cytotoxicity, the mechanisms of cytotoxic activity, genotoxicity, and interaction with DNA and proteins, of two Cu(II) complexes with a salicylaldehyde derivative (4-(diethylamino)salicylaldehyde) and α-diimine (2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen)) are reported. Both Cu(II) complexes performed cytotoxic effects against all tested malignant cell lines. Complexes exerted highest cytotoxicity against HeLa and A375 malignant cell lines. The cytotoxic activity of Cu(II) complex with phen as a α-diimine co-ligand was significantly higher in comparison with cytotoxic activity of Cu(II) complex with bipy. Pretreatment with specific inhibitors of caspase-3, caspase-8 or caspase-9, in order to clear up the mode of cell death triggered by two Cu(II) complexes in HeLa cells, indicated the ability of these complexes to induce apoptosis through activation of target caspases. Cu(II)-phen complex exhibited significant antioxidant activity compared with Cu(II)-bipy complex, and showed a better effect on reducing intracellular ROS levels in HeLa cells. Tested complexes did not display genotoxic potential in human peripheral blood leucocytes, but exhibited an antigenotoxic effect in post-treatment, after H2O2 exposure. The study of the in vitro biological properties regarding their affinity towards CT (calf-thymus) DNA and serum albumins showed that the compounds can intercalate to CT DNA, and bind reversibly and tightly to the albumins. Molecular docking studies of the ability of compounds to bind to biomacromolecules are consistent with in vitro studies.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins
VL  - 235
SP  - 111942
DO  - 10.1016/j.jinorgbio.2022.111942
ER  - 
@article{
author = "Vitomirov, Teodora and Dimiza, Filitsa and Matić, Ivana Z. and Stanojković, Tatjana and Pirković, Andrea and Živković, Lada and Spremo-Potparević, Biljana and Novaković, Irena and Anđelković, Katarina and Milčić, Miloš and Psomas, George and Ristović, Maja Šumar",
year = "2022",
abstract = "In this article, cytotoxicity, the mechanisms of cytotoxic activity, genotoxicity, and interaction with DNA and proteins, of two Cu(II) complexes with a salicylaldehyde derivative (4-(diethylamino)salicylaldehyde) and α-diimine (2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen)) are reported. Both Cu(II) complexes performed cytotoxic effects against all tested malignant cell lines. Complexes exerted highest cytotoxicity against HeLa and A375 malignant cell lines. The cytotoxic activity of Cu(II) complex with phen as a α-diimine co-ligand was significantly higher in comparison with cytotoxic activity of Cu(II) complex with bipy. Pretreatment with specific inhibitors of caspase-3, caspase-8 or caspase-9, in order to clear up the mode of cell death triggered by two Cu(II) complexes in HeLa cells, indicated the ability of these complexes to induce apoptosis through activation of target caspases. Cu(II)-phen complex exhibited significant antioxidant activity compared with Cu(II)-bipy complex, and showed a better effect on reducing intracellular ROS levels in HeLa cells. Tested complexes did not display genotoxic potential in human peripheral blood leucocytes, but exhibited an antigenotoxic effect in post-treatment, after H2O2 exposure. The study of the in vitro biological properties regarding their affinity towards CT (calf-thymus) DNA and serum albumins showed that the compounds can intercalate to CT DNA, and bind reversibly and tightly to the albumins. Molecular docking studies of the ability of compounds to bind to biomacromolecules are consistent with in vitro studies.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins",
volume = "235",
pages = "111942",
doi = "10.1016/j.jinorgbio.2022.111942"
}
Vitomirov, T., Dimiza, F., Matić, I. Z., Stanojković, T., Pirković, A., Živković, L., Spremo-Potparević, B., Novaković, I., Anđelković, K., Milčić, M., Psomas, G.,& Ristović, M. Š.. (2022). Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins. in Journal of Inorganic Biochemistry
Elsevier., 235, 111942.
https://doi.org/10.1016/j.jinorgbio.2022.111942
Vitomirov T, Dimiza F, Matić IZ, Stanojković T, Pirković A, Živković L, Spremo-Potparević B, Novaković I, Anđelković K, Milčić M, Psomas G, Ristović MŠ. Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins. in Journal of Inorganic Biochemistry. 2022;235:111942.
doi:10.1016/j.jinorgbio.2022.111942 .
Vitomirov, Teodora, Dimiza, Filitsa, Matić, Ivana Z., Stanojković, Tatjana, Pirković, Andrea, Živković, Lada, Spremo-Potparević, Biljana, Novaković, Irena, Anđelković, Katarina, Milčić, Miloš, Psomas, George, Ristović, Maja Šumar, "Copper(II) complexes with 4-(diethylamino)salicylaldehyde and α-diimines: Anticancer, antioxidant, antigenotoxic effects and interaction with DNA and albumins" in Journal of Inorganic Biochemistry, 235 (2022):111942,
https://doi.org/10.1016/j.jinorgbio.2022.111942 . .

Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage

Vukadinović, Jelena; Srdić, Jelena; Tosti, Tomislav; Dragičević, Vesna; Kravić, Natalija; Drinić, Snežana Mladenović; Milojković-Opsenica, Dušanka

(Elsevier, 2022)

TY  - JOUR
AU  - Vukadinović, Jelena
AU  - Srdić, Jelena
AU  - Tosti, Tomislav
AU  - Dragičević, Vesna
AU  - Kravić, Natalija
AU  - Drinić, Snežana Mladenović
AU  - Milojković-Opsenica, Dušanka
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5513
AB  - Sweet maize has worldwide importance due to its high nutritional value and health benefits. In order to provide valuable health-related information to consumers, the phytochemicals profile of raw sweet maize kernels and those exposed to different treatments (cooking, frozen storage before cooking, sucrose addition during cooking, and blanching) was examined herein. Thus, carotenoids, tocopherols and free phenolic acids content was determined by liquid chromatography, while the content of water soluble sugars was analyzed by anion exchange chromatography. In response to immediate cooking, as well as, to blanching prior to shorter frozen storage and cooking afterwards, all hybrids exhibited a significant decrease in carotenoids, and a significant increase in concentration of tocopherols, fructose, glucose, protocatechuic, ferulic and p-coumaric acids, in comparison to the fresh samples. However, treatments with blanching prior to longer frozen storage and cooking afterwards, contributed only to increased tocopherols content. Distinct grouping of processed samples in comparison to their corresponding control samples, revealed the existence of unique linkage between changes in phytochemicals content upon treatment in a hybrid-dependent manner. Combined blanching prior to shorter frozen storage with sucrose addition during cooking is highly recommended as a potent tool for phytochemicals enhancement.
PB  - Elsevier
T2  - Journal of Food Composition and Analysis
T1  - Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage
VL  - 114
SP  - 104637
DO  - 10.1016/j.jfca.2022.104637
ER  - 
@article{
author = "Vukadinović, Jelena and Srdić, Jelena and Tosti, Tomislav and Dragičević, Vesna and Kravić, Natalija and Drinić, Snežana Mladenović and Milojković-Opsenica, Dušanka",
year = "2022",
abstract = "Sweet maize has worldwide importance due to its high nutritional value and health benefits. In order to provide valuable health-related information to consumers, the phytochemicals profile of raw sweet maize kernels and those exposed to different treatments (cooking, frozen storage before cooking, sucrose addition during cooking, and blanching) was examined herein. Thus, carotenoids, tocopherols and free phenolic acids content was determined by liquid chromatography, while the content of water soluble sugars was analyzed by anion exchange chromatography. In response to immediate cooking, as well as, to blanching prior to shorter frozen storage and cooking afterwards, all hybrids exhibited a significant decrease in carotenoids, and a significant increase in concentration of tocopherols, fructose, glucose, protocatechuic, ferulic and p-coumaric acids, in comparison to the fresh samples. However, treatments with blanching prior to longer frozen storage and cooking afterwards, contributed only to increased tocopherols content. Distinct grouping of processed samples in comparison to their corresponding control samples, revealed the existence of unique linkage between changes in phytochemicals content upon treatment in a hybrid-dependent manner. Combined blanching prior to shorter frozen storage with sucrose addition during cooking is highly recommended as a potent tool for phytochemicals enhancement.",
publisher = "Elsevier",
journal = "Journal of Food Composition and Analysis",
title = "Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage",
volume = "114",
pages = "104637",
doi = "10.1016/j.jfca.2022.104637"
}
Vukadinović, J., Srdić, J., Tosti, T., Dragičević, V., Kravić, N., Drinić, S. M.,& Milojković-Opsenica, D.. (2022). Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage. in Journal of Food Composition and Analysis
Elsevier., 114, 104637.
https://doi.org/10.1016/j.jfca.2022.104637
Vukadinović J, Srdić J, Tosti T, Dragičević V, Kravić N, Drinić SM, Milojković-Opsenica D. Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage. in Journal of Food Composition and Analysis. 2022;114:104637.
doi:10.1016/j.jfca.2022.104637 .
Vukadinović, Jelena, Srdić, Jelena, Tosti, Tomislav, Dragičević, Vesna, Kravić, Natalija, Drinić, Snežana Mladenović, Milojković-Opsenica, Dušanka, "Alteration in phytochemicals from sweet maize in response to domestic cooking and frozen storage" in Journal of Food Composition and Analysis, 114 (2022):104637,
https://doi.org/10.1016/j.jfca.2022.104637 . .
1

The impact of ferric iron and pH on photo-degradation of tetracycline in water

Korać Jačić, Jelena; Milenković, Milica R.; Bajuk-Bogdanović, Danica; Stanković, Dalibor; Dimitrijević, Milena; Spasojević, Ivan

(Elsevier, 2022)

TY  - JOUR
AU  - Korać Jačić, Jelena
AU  - Milenković, Milica R.
AU  - Bajuk-Bogdanović, Danica
AU  - Stanković, Dalibor
AU  - Dimitrijević, Milena
AU  - Spasojević, Ivan
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5511
AB  - There is a significant interest in understanding coordination and photo-chemistry of tetracycline antibiotics, primarily in relation to the development of advanced oxidation processes for degradation of these pollutants in water processing. Herein we analyzed the pH-dependence of interactions of tetracycline with ferric iron and photosensitivity of tetracycline to UV-A and UV-B, using a set of methods – UV–vis, Raman and electron paramagnetic resonance spectroscopy, MS spectrometry, HPLC, and cyclic voltammetry. Tetracycline and Fe3+ mainly bind through amide and OH groups in tricarbonylamide moiety to form a stable complex with 1:1 stoichiometry at pH ≤ 5. The interaction is reversible and tetracycline is released from the complex with pH increase. Tetracycline in the complex is stabilized and less susceptible than free tetracycline to oxidation by hydroxyl radical that is produced by UV-induced photolysis of Fe3+–OH- complexes. Redox properties of tetracycline were altered with increasing pH and it showed increased susceptibility to UV-induced degradation. In close, the system composed of tetracycline and ferric iron shows coordination and photo-redox chemistry that is dependent of pH in relation to the solubility of Fe3+ species and protonation of tetracycline. The development and optimization of advanced oxidation processes should take into account that iron may bind and stabilize pollutants and that the redox landscape of water changes drastically with pH.
PB  - Elsevier
T2  - Journal of Photochemistry & Photobiology, A: Chemistry
T1  - The impact of ferric iron and pH on photo-degradation of tetracycline in water
VL  - 433
SP  - 114155
DO  - 10.1016/j.jphotochem.2022.114155
ER  - 
@article{
author = "Korać Jačić, Jelena and Milenković, Milica R. and Bajuk-Bogdanović, Danica and Stanković, Dalibor and Dimitrijević, Milena and Spasojević, Ivan",
year = "2022",
abstract = "There is a significant interest in understanding coordination and photo-chemistry of tetracycline antibiotics, primarily in relation to the development of advanced oxidation processes for degradation of these pollutants in water processing. Herein we analyzed the pH-dependence of interactions of tetracycline with ferric iron and photosensitivity of tetracycline to UV-A and UV-B, using a set of methods – UV–vis, Raman and electron paramagnetic resonance spectroscopy, MS spectrometry, HPLC, and cyclic voltammetry. Tetracycline and Fe3+ mainly bind through amide and OH groups in tricarbonylamide moiety to form a stable complex with 1:1 stoichiometry at pH ≤ 5. The interaction is reversible and tetracycline is released from the complex with pH increase. Tetracycline in the complex is stabilized and less susceptible than free tetracycline to oxidation by hydroxyl radical that is produced by UV-induced photolysis of Fe3+–OH- complexes. Redox properties of tetracycline were altered with increasing pH and it showed increased susceptibility to UV-induced degradation. In close, the system composed of tetracycline and ferric iron shows coordination and photo-redox chemistry that is dependent of pH in relation to the solubility of Fe3+ species and protonation of tetracycline. The development and optimization of advanced oxidation processes should take into account that iron may bind and stabilize pollutants and that the redox landscape of water changes drastically with pH.",
publisher = "Elsevier",
journal = "Journal of Photochemistry & Photobiology, A: Chemistry",
title = "The impact of ferric iron and pH on photo-degradation of tetracycline in water",
volume = "433",
pages = "114155",
doi = "10.1016/j.jphotochem.2022.114155"
}
Korać Jačić, J., Milenković, M. R., Bajuk-Bogdanović, D., Stanković, D., Dimitrijević, M.,& Spasojević, I.. (2022). The impact of ferric iron and pH on photo-degradation of tetracycline in water. in Journal of Photochemistry & Photobiology, A: Chemistry
Elsevier., 433, 114155.
https://doi.org/10.1016/j.jphotochem.2022.114155
Korać Jačić J, Milenković MR, Bajuk-Bogdanović D, Stanković D, Dimitrijević M, Spasojević I. The impact of ferric iron and pH on photo-degradation of tetracycline in water. in Journal of Photochemistry & Photobiology, A: Chemistry. 2022;433:114155.
doi:10.1016/j.jphotochem.2022.114155 .
Korać Jačić, Jelena, Milenković, Milica R., Bajuk-Bogdanović, Danica, Stanković, Dalibor, Dimitrijević, Milena, Spasojević, Ivan, "The impact of ferric iron and pH on photo-degradation of tetracycline in water" in Journal of Photochemistry & Photobiology, A: Chemistry, 433 (2022):114155,
https://doi.org/10.1016/j.jphotochem.2022.114155 . .

Investigations on the role of cation–pi interactions in active centres of superoxide dismutase

Stojanović, Srđan Đ.; Zlatović, Mario V.

(Serbian Chemical Society, 2022)

TY  - JOUR
AU  - Stojanović, Srđan Đ.
AU  - Zlatović, Mario V.
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5507
AB  - In this study, we have analysed the influence of cation–π interactions on stability and properties of superoxide dismutase (SOD) active centres. The number of interactions formed by arginine is higher than by lysine in the cat­ionic group, while those formed by histidine are comparatively higher in the π group. The energy contribution resulting from most frequent cation–π interact­ions was in the lower range of strong hydrogen bonds. The cation–π interact­ions involving transition metal ions as cation have energy more negative than –418.4 kJ mol-1. The stabilization centres for these proteins showed that all the residues involved in cation–π interactions were important in locating one or more of such centres. The majority of the residues involved in cation–p inter­actions were evolutionarily conserved and might have a significant contribution towards the stability of SOD proteins. The results presented in this work can be very useful for understanding the contribution of cation–π interactions to the stability of SOD active centres.
PB  - Serbian Chemical Society
T2  - The Journal of the Serbian Chemical Society
T1  - Investigations on the role of cation–pi interactions in active centres of superoxide dismutase
VL  - 87
IS  - 4
SP  - 465
EP  - 477
DO  - 10.2298/JSC220109013S
ER  - 
@article{
author = "Stojanović, Srđan Đ. and Zlatović, Mario V.",
year = "2022",
abstract = "In this study, we have analysed the influence of cation–π interactions on stability and properties of superoxide dismutase (SOD) active centres. The number of interactions formed by arginine is higher than by lysine in the cat­ionic group, while those formed by histidine are comparatively higher in the π group. The energy contribution resulting from most frequent cation–π interact­ions was in the lower range of strong hydrogen bonds. The cation–π interact­ions involving transition metal ions as cation have energy more negative than –418.4 kJ mol-1. The stabilization centres for these proteins showed that all the residues involved in cation–π interactions were important in locating one or more of such centres. The majority of the residues involved in cation–p inter­actions were evolutionarily conserved and might have a significant contribution towards the stability of SOD proteins. The results presented in this work can be very useful for understanding the contribution of cation–π interactions to the stability of SOD active centres.",
publisher = "Serbian Chemical Society",
journal = "The Journal of the Serbian Chemical Society",
title = "Investigations on the role of cation–pi interactions in active centres of superoxide dismutase",
volume = "87",
number = "4",
pages = "465-477",
doi = "10.2298/JSC220109013S"
}
Stojanović, S. Đ.,& Zlatović, M. V.. (2022). Investigations on the role of cation–pi interactions in active centres of superoxide dismutase. in The Journal of the Serbian Chemical Society
Serbian Chemical Society., 87(4), 465-477.
https://doi.org/10.2298/JSC220109013S
Stojanović SĐ, Zlatović MV. Investigations on the role of cation–pi interactions in active centres of superoxide dismutase. in The Journal of the Serbian Chemical Society. 2022;87(4):465-477.
doi:10.2298/JSC220109013S .
Stojanović, Srđan Đ., Zlatović, Mario V., "Investigations on the role of cation–pi interactions in active centres of superoxide dismutase" in The Journal of the Serbian Chemical Society, 87, no. 4 (2022):465-477,
https://doi.org/10.2298/JSC220109013S . .
1

Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats

Perić, Ivana; Lješević, Marija; Beškoski, Vladimir P.; Nikolić, Milan; Filipović, Dragana

(2022)

TY  - JOUR
AU  - Perić, Ivana
AU  - Lješević, Marija
AU  - Beškoski, Vladimir P.
AU  - Nikolić, Milan
AU  - Filipović, Dragana
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5499
AB  - Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.
T2  - Psychopharmacology
T1  - Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats
VL  - n/a
DO  - 10.1007/s00213-022-06180-y
ER  - 
@article{
author = "Perić, Ivana and Lješević, Marija and Beškoski, Vladimir P. and Nikolić, Milan and Filipović, Dragana",
year = "2022",
abstract = "Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD.",
journal = "Psychopharmacology",
title = "Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats",
volume = "n/a",
doi = "10.1007/s00213-022-06180-y"
}
Perić, I., Lješević, M., Beškoski, V. P., Nikolić, M.,& Filipović, D.. (2022). Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. in Psychopharmacology, n/a.
https://doi.org/10.1007/s00213-022-06180-y
Perić I, Lješević M, Beškoski VP, Nikolić M, Filipović D. Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. in Psychopharmacology. 2022;n/a.
doi:10.1007/s00213-022-06180-y .
Perić, Ivana, Lješević, Marija, Beškoski, Vladimir P., Nikolić, Milan, Filipović, Dragana, "Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats" in Psychopharmacology, n/a (2022),
https://doi.org/10.1007/s00213-022-06180-y . .
1
1

Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity

Stevanović, Nevena; Zlatar, Matija; Novaković, Irena T.; Pevec, Andrej; Radanović, Dušanka D.; Matić, Ivana Z.; Đorđić Crnogorac, Marija; Stanojković, Tatjana; Vujčić, Miroslava; Gruden, Maja; Sladić, Dušan; Anđelković, Katarina K.; Turel, Iztok; Čobeljić, Božidar

(Royal Society of Chemistry (RSC), 2022)

TY  - JOUR
AU  - Stevanović, Nevena
AU  - Zlatar, Matija
AU  - Novaković, Irena T.
AU  - Pevec, Andrej
AU  - Radanović, Dušanka D.
AU  - Matić, Ivana Z.
AU  - Đorđić Crnogorac, Marija
AU  - Stanojković, Tatjana
AU  - Vujčić, Miroslava
AU  - Gruden, Maja
AU  - Sladić, Dušan
AU  - Anđelković, Katarina K.
AU  - Turel, Iztok
AU  - Čobeljić, Božidar
PY  - 2022
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/4857
AB  - In this paper, Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and DFT calculations. In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear penta-coordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], respectively, while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-negative and Gram-positive bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin.
PB  - Royal Society of Chemistry (RSC)
T2  - Dalton Transactions
T1  - Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity
VL  - 51
IS  - 1
SP  - 185
EP  - 196
DO  - 10.1039/D1DT03169D
ER  - 
@article{
author = "Stevanović, Nevena and Zlatar, Matija and Novaković, Irena T. and Pevec, Andrej and Radanović, Dušanka D. and Matić, Ivana Z. and Đorđić Crnogorac, Marija and Stanojković, Tatjana and Vujčić, Miroslava and Gruden, Maja and Sladić, Dušan and Anđelković, Katarina K. and Turel, Iztok and Čobeljić, Božidar",
year = "2022",
abstract = "In this paper, Cu(II), Mn(II) and Zn(II) complexes with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL1Cl) were synthesized and characterized by single-crystal X-ray diffraction, IR spectroscopy, elemental analysis and DFT calculations. In all three complexes, a ligand (L1) is coordinated in a deprotonated formally neutral zwitterionic form via NNO donor set atoms. Cu(II) and Zn(II) form mononuclear penta-coordinated complexes [CuL1(N3)(CH3OH)]BF4 and [ZnL1(N3)2], respectively, while Mn(II) forms a binuclear [Mn2L12(μ-1,1-N3)2(N3)2]·2CH3OH complex, with unusual distorted trigonal-prismatic geometry around the metal centers. The antimicrobial activity of these complexes was tested against a panel of Gram-negative and Gram-positive bacteria, two yeasts and one fungal strain. The binuclear Mn(II) complex showed antifungal activity of similar intensity to amphotericin B. Based on the results of the brine shrimp test and DPPH radical scavenging activity, the most active Cu(II) and Mn(II) complexes were selected for evaluation of cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and one normal cell line HaCaT. Both complexes showed significant activity. It should be pointed out that the activity of the Mn(II) complex against the MCF7 breast cancer cell line is only slightly weaker than that of cisplatin, but with selectivity to the tumor cell line in comparison to normal HaCaT cells, which is non-existent in the case of cisplatin.",
publisher = "Royal Society of Chemistry (RSC)",
journal = "Dalton Transactions",
title = "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity",
volume = "51",
number = "1",
pages = "185-196",
doi = "10.1039/D1DT03169D"
}
Stevanović, N., Zlatar, M., Novaković, I. T., Pevec, A., Radanović, D. D., Matić, I. Z., Đorđić Crnogorac, M., Stanojković, T., Vujčić, M., Gruden, M., Sladić, D., Anđelković, K. K., Turel, I.,& Čobeljić, B.. (2022). Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity. in Dalton Transactions
Royal Society of Chemistry (RSC)., 51(1), 185-196.
https://doi.org/10.1039/D1DT03169D
Stevanović N, Zlatar M, Novaković IT, Pevec A, Radanović DD, Matić IZ, Đorđić Crnogorac M, Stanojković T, Vujčić M, Gruden M, Sladić D, Anđelković KK, Turel I, Čobeljić B. Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity. in Dalton Transactions. 2022;51(1):185-196.
doi:10.1039/D1DT03169D .
Stevanović, Nevena, Zlatar, Matija, Novaković, Irena T., Pevec, Andrej, Radanović, Dušanka D., Matić, Ivana Z., Đorđić Crnogorac, Marija, Stanojković, Tatjana, Vujčić, Miroslava, Gruden, Maja, Sladić, Dušan, Anđelković, Katarina K., Turel, Iztok, Čobeljić, Božidar, "Cu(II), Mn(II) and Zn(II) complexes of hydrazones with a quaternary ammonium moiety: synthesis, experimental and theoretical characterization and cytotoxic activity" in Dalton Transactions, 51, no. 1 (2022):185-196,
https://doi.org/10.1039/D1DT03169D . .
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