TY  - JOUR
AU  - Pavlović, Tamara
AU  - Dimkić, Ivica
AU  - Andrić, Snežana
AU  - Milojković-Opsenica, Dušanka
AU  - Stanković, Slaviša
AU  - Janaćković, Peđa T.
AU  - Gavrilović, Milan
AU  - Ristivojević, Petar
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4040
AB  - Linden tea has been used in Serbian folk medicine for centuries to induce sweating for colds, relieve throat irritation and cough, reduce blood pressure, as well as a diuretic, spasmolytic, and as a sedative. The main aim of this study was to determine the comprehensive metabolite profile, free radical scavenging activity, and antimicrobial activities against 23 human and plant pathogens of both commercial and field-collected linden tea samples from Serbia. Developed high-performance thin-layer chromatography (HPTLC) method allowed identification of eight major metabolites in investigated samples, while forty-six metabolites were tentatively identified using high resolution mass spectrometry (HRMS): 14 phenolic acids and their derivatives, 15 glycosides, 9 flavonoids, and 8 procyanidins. Both commercial and field-collected linden tea samples showed similar total phenolic content and radical scavenging activity. Seven compounds such as p-hydroxybenzoic acid 4-O-hexoside, caffeic acid cinnamyl ester, pinocembrin, galangin, luteolin 7-O-glucuronide (and its isomer), isorhamnetin hexosyl hexoside were found in Tilia samples for the first time. Radical reagent 2,2-Diphenyl-1-picrylhydrazyl· (DPPH·) was used in DPPH-HPTLC assay which identified chlorogenic acid, caffeic acid, astragalin, quercitrin, tiliroside, and rutin as compounds that exhibit radical scavenging activity. Tilia samples showed inhibitory effect overwhelming only on Gram-positive bacteria, especially on Bacillus subtilis with the lowest MIC values observed, as well as towards Staphylococcus aureus and oral cavity isolates of Streptococcus pyogenes and Streptococcus mutans. Vaginal isolate of Candida glabrata showed more susceptibility than Candida albicans isolate. Generally, extract from Tilia cordata Miller (L4) showed the highest antimicrobial activity against the most of the tested pathogens, among all field-collected Tilia samples.
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Linden tea from Serbia – an insight into the phenolic profile, radical scavenging and antimicrobial activities
VL  - 154
SP  - 112639
DO  - 10.1016/j.indcrop.2020.112639
ER  - 

@article{
author = "Pavlović, Tamara and Dimkić, Ivica and Andrić, Snežana and Milojković-Opsenica, Dušanka and Stanković, Slaviša and Janaćković, Peđa T. and Gavrilović, Milan and Ristivojević, Petar",
year = "2020",
abstract = "Linden tea has been used in Serbian folk medicine for centuries to induce sweating for colds, relieve throat irritation and cough, reduce blood pressure, as well as a diuretic, spasmolytic, and as a sedative. The main aim of this study was to determine the comprehensive metabolite profile, free radical scavenging activity, and antimicrobial activities against 23 human and plant pathogens of both commercial and field-collected linden tea samples from Serbia. Developed high-performance thin-layer chromatography (HPTLC) method allowed identification of eight major metabolites in investigated samples, while forty-six metabolites were tentatively identified using high resolution mass spectrometry (HRMS): 14 phenolic acids and their derivatives, 15 glycosides, 9 flavonoids, and 8 procyanidins. Both commercial and field-collected linden tea samples showed similar total phenolic content and radical scavenging activity. Seven compounds such as p-hydroxybenzoic acid 4-O-hexoside, caffeic acid cinnamyl ester, pinocembrin, galangin, luteolin 7-O-glucuronide (and its isomer), isorhamnetin hexosyl hexoside were found in Tilia samples for the first time. Radical reagent 2,2-Diphenyl-1-picrylhydrazyl· (DPPH·) was used in DPPH-HPTLC assay which identified chlorogenic acid, caffeic acid, astragalin, quercitrin, tiliroside, and rutin as compounds that exhibit radical scavenging activity. Tilia samples showed inhibitory effect overwhelming only on Gram-positive bacteria, especially on Bacillus subtilis with the lowest MIC values observed, as well as towards Staphylococcus aureus and oral cavity isolates of Streptococcus pyogenes and Streptococcus mutans. Vaginal isolate of Candida glabrata showed more susceptibility than Candida albicans isolate. Generally, extract from Tilia cordata Miller (L4) showed the highest antimicrobial activity against the most of the tested pathogens, among all field-collected Tilia samples.",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Linden tea from Serbia – an insight into the phenolic profile, radical scavenging and antimicrobial activities",
volume = "154",
pages = "112639",
doi = "10.1016/j.indcrop.2020.112639"
}

Pavlović, T., Dimkić, I., Andrić, S., Milojković-Opsenica, D., Stanković, S., Janaćković, P. T., Gavrilović, M.,& Ristivojević, P.. (2020). Linden tea from Serbia – an insight into the phenolic profile, radical scavenging and antimicrobial activities. in Industrial Crops and Products
Elsevier., 154, 112639.
https://doi.org/10.1016/j.indcrop.2020.112639

Pavlović T, Dimkić I, Andrić S, Milojković-Opsenica D, Stanković S, Janaćković PT, Gavrilović M, Ristivojević P. Linden tea from Serbia – an insight into the phenolic profile, radical scavenging and antimicrobial activities. in Industrial Crops and Products. 2020;154:112639.
doi:10.1016/j.indcrop.2020.112639 .

Pavlović, Tamara, Dimkić, Ivica, Andrić, Snežana, Milojković-Opsenica, Dušanka, Stanković, Slaviša, Janaćković, Peđa T., Gavrilović, Milan, Ristivojević, Petar, "Linden tea from Serbia – an insight into the phenolic profile, radical scavenging and antimicrobial activities" in Industrial Crops and Products, 154 (2020):112639,
https://doi.org/10.1016/j.indcrop.2020.112639 . .

TY  - DATA
AU  - Pavlović, Tamara
AU  - Dimkić, Ivica
AU  - Andrić, Snežana
AU  - Milojković-Opsenica, Dušanka
AU  - Stanković, Slaviša
AU  - Janaćković, Peđa T.
AU  - Gavrilović, Milan
AU  - Ristivojević, Petar
PY  - 2020
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/4041
PB  - Elsevier
T2  - Industrial Crops and Products
T1  - Supplementary data for the article: Pavlović, T.; Dimkić, I.; Andrić, S.; Milojković-Opsenica, D.; Stanković, S.; Janaćković, P.; Gavrilović, M.; Ristivojević, P. Linden Tea from Serbia – an Insight into the Phenolic Profile, Radical Scavenging and Antimicrobial Activities. Industrial Crops and Products 2020, 154, 112639. https://doi.org/10.1016/j.indcrop.2020.112639
UR  - https://hdl.handle.net/21.15107/rcub_cherry_4041
ER  - 

@misc{
author = "Pavlović, Tamara and Dimkić, Ivica and Andrić, Snežana and Milojković-Opsenica, Dušanka and Stanković, Slaviša and Janaćković, Peđa T. and Gavrilović, Milan and Ristivojević, Petar",
year = "2020",
publisher = "Elsevier",
journal = "Industrial Crops and Products",
title = "Supplementary data for the article: Pavlović, T.; Dimkić, I.; Andrić, S.; Milojković-Opsenica, D.; Stanković, S.; Janaćković, P.; Gavrilović, M.; Ristivojević, P. Linden Tea from Serbia – an Insight into the Phenolic Profile, Radical Scavenging and Antimicrobial Activities. Industrial Crops and Products 2020, 154, 112639. https://doi.org/10.1016/j.indcrop.2020.112639",
url = "https://hdl.handle.net/21.15107/rcub_cherry_4041"
}

Pavlović, T., Dimkić, I., Andrić, S., Milojković-Opsenica, D., Stanković, S., Janaćković, P. T., Gavrilović, M.,& Ristivojević, P.. (2020). Supplementary data for the article: Pavlović, T.; Dimkić, I.; Andrić, S.; Milojković-Opsenica, D.; Stanković, S.; Janaćković, P.; Gavrilović, M.; Ristivojević, P. Linden Tea from Serbia – an Insight into the Phenolic Profile, Radical Scavenging and Antimicrobial Activities. Industrial Crops and Products 2020, 154, 112639. https://doi.org/10.1016/j.indcrop.2020.112639. in Industrial Crops and Products
Elsevier..
https://hdl.handle.net/21.15107/rcub_cherry_4041

Pavlović T, Dimkić I, Andrić S, Milojković-Opsenica D, Stanković S, Janaćković PT, Gavrilović M, Ristivojević P. Supplementary data for the article: Pavlović, T.; Dimkić, I.; Andrić, S.; Milojković-Opsenica, D.; Stanković, S.; Janaćković, P.; Gavrilović, M.; Ristivojević, P. Linden Tea from Serbia – an Insight into the Phenolic Profile, Radical Scavenging and Antimicrobial Activities. Industrial Crops and Products 2020, 154, 112639. https://doi.org/10.1016/j.indcrop.2020.112639. in Industrial Crops and Products. 2020;.
https://hdl.handle.net/21.15107/rcub_cherry_4041 .

Pavlović, Tamara, Dimkić, Ivica, Andrić, Snežana, Milojković-Opsenica, Dušanka, Stanković, Slaviša, Janaćković, Peđa T., Gavrilović, Milan, Ristivojević, Petar, "Supplementary data for the article: Pavlović, T.; Dimkić, I.; Andrić, S.; Milojković-Opsenica, D.; Stanković, S.; Janaćković, P.; Gavrilović, M.; Ristivojević, P. Linden Tea from Serbia – an Insight into the Phenolic Profile, Radical Scavenging and Antimicrobial Activities. Industrial Crops and Products 2020, 154, 112639. https://doi.org/10.1016/j.indcrop.2020.112639" in Industrial Crops and Products (2020),
https://hdl.handle.net/21.15107/rcub_cherry_4041 .