TY  - CONF
AU  - Dimitrijević, Marija
AU  - Mihajlović-Lalić, Ljiljana
AU  - Grgurić-Šipka, Sanja
AU  - Nikolić, Stefan
AU  - Petrović, Tamara
AU  - Poljarević, Jelena
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5904
AB  - Metal-based compounds are rarely good antimicrobial compounds. Here we report
synthesis, chemical characterization and antimicrobial potency of fourteen Ru(II) arene
complexes with pyridine-based ligands. The structures and purity of synthesized
compounds were confirmed using 1H and 13C NMR spectroscopy, IR spectroscopy, MS, and
EA. A micro-well dilution assay was used to determine the minimum inhibitory
concentration (MIC), and minimum bactericidal concentration. of evaluated compounds.
Streptomycin and chloramphenicol were used as a positive control. The best activity of all
tested bacteria was observed against E. coli, with a MIC value of 1.25 mg/mL, for
complexes with 2,4- i 2,5-pyridinedicarboxylic ligands. Also, all synthesized complexes
showed the same activity against C. Albicans.
AB  - Kompleksi metala retko se koriste kao potencijalni antimikrobni agensi. U ovom radu smo prikazali sintezu, hemijsku karakterizaciju i antimikrobnu aktivnost 14 arenskih Ru(II) kompleksa sa piridinskim ligandima. Strukturu i čistoću dobijenih jedinjenja potvrdili smo koristeći 1H, 13C NMR i IC spektroskopiju, MS i EA. Mikrodilucioni esej je korišćen za određivanje minimalne inhibitorne koncentracije (MIC) i minimalne baktericidne koncentracije sintetisanih jedinjenja. Streptomicin i hloramfenikol su korišćeni kao standard. Najbolja aktivnost prema ispitivanim sojevima bakterija zapažena je na soju E. coli, sa MIC vrednošću 1,25 mg/mL, kompleksa sa 2,4- i 2,5-piridindikarboksilnim ligandima. Svi sintetisani kompleksi pokazali su podjednako dobru aktivnost prema C. Albicans.
PB  - Belgrade : Serbian Chemical Society
C3  - 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia
T1  - Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency
SP  - 74
EP  - 74
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5904
ER  - 

@conference{
author = "Dimitrijević, Marija and Mihajlović-Lalić, Ljiljana and Grgurić-Šipka, Sanja and Nikolić, Stefan and Petrović, Tamara and Poljarević, Jelena",
year = "2023",
abstract = "Metal-based compounds are rarely good antimicrobial compounds. Here we report
synthesis, chemical characterization and antimicrobial potency of fourteen Ru(II) arene
complexes with pyridine-based ligands. The structures and purity of synthesized
compounds were confirmed using 1H and 13C NMR spectroscopy, IR spectroscopy, MS, and
EA. A micro-well dilution assay was used to determine the minimum inhibitory
concentration (MIC), and minimum bactericidal concentration. of evaluated compounds.
Streptomycin and chloramphenicol were used as a positive control. The best activity of all
tested bacteria was observed against E. coli, with a MIC value of 1.25 mg/mL, for
complexes with 2,4- i 2,5-pyridinedicarboxylic ligands. Also, all synthesized complexes
showed the same activity against C. Albicans., Kompleksi metala retko se koriste kao potencijalni antimikrobni agensi. U ovom radu smo prikazali sintezu, hemijsku karakterizaciju i antimikrobnu aktivnost 14 arenskih Ru(II) kompleksa sa piridinskim ligandima. Strukturu i čistoću dobijenih jedinjenja potvrdili smo koristeći 1H, 13C NMR i IC spektroskopiju, MS i EA. Mikrodilucioni esej je korišćen za određivanje minimalne inhibitorne koncentracije (MIC) i minimalne baktericidne koncentracije sintetisanih jedinjenja. Streptomicin i hloramfenikol su korišćeni kao standard. Najbolja aktivnost prema ispitivanim sojevima bakterija zapažena je na soju E. coli, sa MIC vrednošću 1,25 mg/mL, kompleksa sa 2,4- i 2,5-piridindikarboksilnim ligandima. Svi sintetisani kompleksi pokazali su podjednako dobru aktivnost prema C. Albicans.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia",
title = "Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency",
pages = "74-74",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5904"
}

Dimitrijević, M., Mihajlović-Lalić, L., Grgurić-Šipka, S., Nikolić, S., Petrović, T.,& Poljarević, J.. (2023). Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency. in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia
Belgrade : Serbian Chemical Society., 74-74.
https://hdl.handle.net/21.15107/rcub_cherry_5904

Dimitrijević M, Mihajlović-Lalić L, Grgurić-Šipka S, Nikolić S, Petrović T, Poljarević J. Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency. in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia. 2023;:74-74.
https://hdl.handle.net/21.15107/rcub_cherry_5904 .

Dimitrijević, Marija, Mihajlović-Lalić, Ljiljana, Grgurić-Šipka, Sanja, Nikolić, Stefan, Petrović, Tamara, Poljarević, Jelena, "Ru(II) arene based pyridil complexes: synthesis and antimicrobial potency" in 59th Meeting of the Serbian Chemical Society, Book of Abstracts, June 1-2, 2023, Novi Sad, Serbia (2023):74-74,
https://hdl.handle.net/21.15107/rcub_cherry_5904 .

TY  - JOUR
AU  - Stolić Jovanović, Aleksandra
AU  - Martinović, Milica
AU  - Žugić, Ana
AU  - Nešić, Ivana
AU  - Tosti, Tomislav
AU  - Blagojević, Stevan
AU  - Tadić, Vanja M.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6195
AB  - The dual controlled release of emulgels makes them efficient drug delivery systems of increasing interest. The framework of this study was to incorporate selected L-ascorbic acid derivatives into emulgels. From the formulated emulgels, the release profiles of actives were evaluated considering their different polarities and concentrations, and consequently their effectiveness on the skin via a long-term in vivo study that lasted for 30 days was determined. Skin effects were assessed by measuring the electrical capacitance of the stratum corneum (EC), trans-epidermal water loss (TEWL), melanin index (MI) and skin pH. In addition, the sensory and textural properties of emulgel formulations were compared with each other. The changes in the rate of the release of the L-ascorbic acid derivatives were monitored using the Franz diffusion cells. The obtained data were statistically significant, and indicated an increase in the degree of hydration of the skin and skin whitening potential, while no significant changes in TEWL and pH values were detected. The consistency, firmness and stickiness of the emulgels were estimated by volunteers applying the established sensory evaluation protocol. In addition, it was revealed that the difference in hydrophilic/lipophilic properties of L-ascorbic acid derivatives influenced their release profiles without changing their textural characteristics. Therefore, this study highlighted emulgels as L-ascorbic acid suitable carrier systems and one of the promising candidates as novel drug delivery systems.
PB  - MDPI
T2  - Pharmaceutics
T1  - Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System
VL  - 15
IS  - 3
SP  - 813
DO  - 10.3390/pharmaceutics15030813
ER  - 

@article{
author = "Stolić Jovanović, Aleksandra and Martinović, Milica and Žugić, Ana and Nešić, Ivana and Tosti, Tomislav and Blagojević, Stevan and Tadić, Vanja M.",
year = "2023",
abstract = "The dual controlled release of emulgels makes them efficient drug delivery systems of increasing interest. The framework of this study was to incorporate selected L-ascorbic acid derivatives into emulgels. From the formulated emulgels, the release profiles of actives were evaluated considering their different polarities and concentrations, and consequently their effectiveness on the skin via a long-term in vivo study that lasted for 30 days was determined. Skin effects were assessed by measuring the electrical capacitance of the stratum corneum (EC), trans-epidermal water loss (TEWL), melanin index (MI) and skin pH. In addition, the sensory and textural properties of emulgel formulations were compared with each other. The changes in the rate of the release of the L-ascorbic acid derivatives were monitored using the Franz diffusion cells. The obtained data were statistically significant, and indicated an increase in the degree of hydration of the skin and skin whitening potential, while no significant changes in TEWL and pH values were detected. The consistency, firmness and stickiness of the emulgels were estimated by volunteers applying the established sensory evaluation protocol. In addition, it was revealed that the difference in hydrophilic/lipophilic properties of L-ascorbic acid derivatives influenced their release profiles without changing their textural characteristics. Therefore, this study highlighted emulgels as L-ascorbic acid suitable carrier systems and one of the promising candidates as novel drug delivery systems.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System",
volume = "15",
number = "3",
pages = "813",
doi = "10.3390/pharmaceutics15030813"
}

Stolić Jovanović, A., Martinović, M., Žugić, A., Nešić, I., Tosti, T., Blagojević, S.,& Tadić, V. M.. (2023). Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System. in Pharmaceutics
MDPI., 15(3), 813.
https://doi.org/10.3390/pharmaceutics15030813

Stolić Jovanović A, Martinović M, Žugić A, Nešić I, Tosti T, Blagojević S, Tadić VM. Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System. in Pharmaceutics. 2023;15(3):813.
doi:10.3390/pharmaceutics15030813 .

Stolić Jovanović, Aleksandra, Martinović, Milica, Žugić, Ana, Nešić, Ivana, Tosti, Tomislav, Blagojević, Stevan, Tadić, Vanja M., "Derivatives of L-Ascorbic Acid in Emulgel: Development and Comprehensive Evaluation of the Topical Delivery System" in Pharmaceutics, 15, no. 3 (2023):813,
https://doi.org/10.3390/pharmaceutics15030813 . .

TY  - JOUR
AU  - Dimitrijević, Marija
AU  - Mihajlović-Lalić, Ljiljana
AU  - Grgurić-Šipka, Sanja
AU  - Mihajlov-Krstev, Tatjana
AU  - Miladinović, Dragoljub
AU  - Poljarević, Jelena
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5903
AB  - Eleven new and three reported half-sandwich Ru(II) arene complexes were synthesized using [Ru(g6-benzene)Cl(l-Cl)]2 and
[Ru(g6-toluene)Cl(l-Cl)]2 and four pyridine carboxylic acid-based
ligands (dicarboxylic acids and halogen derivatives). The structures
and purity of synthesized compounds were confirmed using 1H
and 13C NMR spectroscopy, infrared spectroscopy, mass spectrometry, and elemental analysis. The stability of synthesized compounds in dimethyl sulfoxide solution was confirmed using 1H
NMR spectroscopy. The seven ligands, two complex precursors
(CP1 and CP2), and 14 half-sandwich Ru(II) picolinate complexes
(C1–C14) were evaluated for in vitro antibacterial and antifungal
activity against pathogens, such as Staphylococcus aureus, Bacillus
cereus, Proteus mirabilis, Klebsiella pneumoniae, Ecsherichia coli,
Pseudomonas aeruginosa, Salmonella enteritidis, Enterobacter aerogenes, and yeast Candida albicans, using the microwell-dilution
method. Among the tested samples, the ligands showed better
inhibitory effect against Gram-positive bacteria when compared
to the metal complexes. The most susceptible Gram-negative bacteria was Ecsherichia coli, with a MIC value of 1.25 mg/mL, for C3,
C6, and C10. All synthesized complexes showed similar, slightly
better activity against Candida albicans.
PB  - Taylor & Francis
T2  - Journal of Coordination Chemistry
T1  - Synthesis, chemical characterization, and antimicrobial potency of picolinate-based halfsandwich Ru(II) complexes
VL  - 76
IS  - 5-6
SP  - 783
EP  - 797
DO  - 10.1080/00958972.2023.2195965
ER  - 

@article{
author = "Dimitrijević, Marija and Mihajlović-Lalić, Ljiljana and Grgurić-Šipka, Sanja and Mihajlov-Krstev, Tatjana and Miladinović, Dragoljub and Poljarević, Jelena",
year = "2023",
abstract = "Eleven new and three reported half-sandwich Ru(II) arene complexes were synthesized using [Ru(g6-benzene)Cl(l-Cl)]2 and
[Ru(g6-toluene)Cl(l-Cl)]2 and four pyridine carboxylic acid-based
ligands (dicarboxylic acids and halogen derivatives). The structures
and purity of synthesized compounds were confirmed using 1H
and 13C NMR spectroscopy, infrared spectroscopy, mass spectrometry, and elemental analysis. The stability of synthesized compounds in dimethyl sulfoxide solution was confirmed using 1H
NMR spectroscopy. The seven ligands, two complex precursors
(CP1 and CP2), and 14 half-sandwich Ru(II) picolinate complexes
(C1–C14) were evaluated for in vitro antibacterial and antifungal
activity against pathogens, such as Staphylococcus aureus, Bacillus
cereus, Proteus mirabilis, Klebsiella pneumoniae, Ecsherichia coli,
Pseudomonas aeruginosa, Salmonella enteritidis, Enterobacter aerogenes, and yeast Candida albicans, using the microwell-dilution
method. Among the tested samples, the ligands showed better
inhibitory effect against Gram-positive bacteria when compared
to the metal complexes. The most susceptible Gram-negative bacteria was Ecsherichia coli, with a MIC value of 1.25 mg/mL, for C3,
C6, and C10. All synthesized complexes showed similar, slightly
better activity against Candida albicans.",
publisher = "Taylor & Francis",
journal = "Journal of Coordination Chemistry",
title = "Synthesis, chemical characterization, and antimicrobial potency of picolinate-based halfsandwich Ru(II) complexes",
volume = "76",
number = "5-6",
pages = "783-797",
doi = "10.1080/00958972.2023.2195965"
}

Dimitrijević, M., Mihajlović-Lalić, L., Grgurić-Šipka, S., Mihajlov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2023). Synthesis, chemical characterization, and antimicrobial potency of picolinate-based halfsandwich Ru(II) complexes. in Journal of Coordination Chemistry
Taylor & Francis., 76(5-6), 783-797.
https://doi.org/10.1080/00958972.2023.2195965

Dimitrijević M, Mihajlović-Lalić L, Grgurić-Šipka S, Mihajlov-Krstev T, Miladinović D, Poljarević J. Synthesis, chemical characterization, and antimicrobial potency of picolinate-based halfsandwich Ru(II) complexes. in Journal of Coordination Chemistry. 2023;76(5-6):783-797.
doi:10.1080/00958972.2023.2195965 .

Dimitrijević, Marija, Mihajlović-Lalić, Ljiljana, Grgurić-Šipka, Sanja, Mihajlov-Krstev, Tatjana, Miladinović, Dragoljub, Poljarević, Jelena, "Synthesis, chemical characterization, and antimicrobial potency of picolinate-based halfsandwich Ru(II) complexes" in Journal of Coordination Chemistry, 76, no. 5-6 (2023):783-797,
https://doi.org/10.1080/00958972.2023.2195965 . .