TY  - JOUR
AU  - Damljanovic, Ivan
AU  - Vukicevic, Mirjana
AU  - Manojlović, Dragan D.
AU  - Šojić, Nešo
AU  - Buriez, Olivier
AU  - Vukicevic, Rastko D.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1042
AB  - The electrochemical bromination of 3,4.6-tri-O-acetyl-D-glucal (1) has been investigated in dimethyl sulfoxide (DMSO) by cyclic voltammetry and preparative-scale electrolyses. In this solvent, the bromination involves a bromine-DMSO complex of the type [DMSO-Br](+) Br(-) whose reactivity towards 1 was clearly evidenced by cyclic voltammetry. Importantly, only the monobrominated glucose and mannose derivatives were obtained from electrolyses. This specific behavior was attributed to the nucleophilicity of DMSO that may react with the oxocarbenium intermediate preventing thus a possible second bromination of the transient species. The gluco/manno ratio, roughly equal to 30/70, indicated an electrophilic attack by [DMSO-Br](+) Br(-) preferentially from the beta side of the starting glycal for steric reasons. The treatment of the crude product obtained after the end of the electrolyses with acetic anhydride allowed the preparation of derivatives in which the anomeric carbon bears an acetoxy group. Based on both the cyclic voltammetry experiments and preparative-scale electrolyses, a mechanism is proposed for the bromination of peracetylated D-glucal in DMSO. These new and original results are of high interest in carbohydrate chemistry and especially for the preparation of new valuable oligosaccharides. (C) 2009 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Electrochimica Acta
T1  - Electrochemical bromination of peracetylated D-glucal: Effect of DMSO on chemoselectivity
VL  - 55
IS  - 3
SP  - 965
EP  - 969
DO  - 10.1016/j.electacta.2009.09.057
ER  - 

@article{
author = "Damljanovic, Ivan and Vukicevic, Mirjana and Manojlović, Dragan D. and Šojić, Nešo and Buriez, Olivier and Vukicevic, Rastko D.",
year = "2010",
abstract = "The electrochemical bromination of 3,4.6-tri-O-acetyl-D-glucal (1) has been investigated in dimethyl sulfoxide (DMSO) by cyclic voltammetry and preparative-scale electrolyses. In this solvent, the bromination involves a bromine-DMSO complex of the type [DMSO-Br](+) Br(-) whose reactivity towards 1 was clearly evidenced by cyclic voltammetry. Importantly, only the monobrominated glucose and mannose derivatives were obtained from electrolyses. This specific behavior was attributed to the nucleophilicity of DMSO that may react with the oxocarbenium intermediate preventing thus a possible second bromination of the transient species. The gluco/manno ratio, roughly equal to 30/70, indicated an electrophilic attack by [DMSO-Br](+) Br(-) preferentially from the beta side of the starting glycal for steric reasons. The treatment of the crude product obtained after the end of the electrolyses with acetic anhydride allowed the preparation of derivatives in which the anomeric carbon bears an acetoxy group. Based on both the cyclic voltammetry experiments and preparative-scale electrolyses, a mechanism is proposed for the bromination of peracetylated D-glucal in DMSO. These new and original results are of high interest in carbohydrate chemistry and especially for the preparation of new valuable oligosaccharides. (C) 2009 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Electrochimica Acta",
title = "Electrochemical bromination of peracetylated D-glucal: Effect of DMSO on chemoselectivity",
volume = "55",
number = "3",
pages = "965-969",
doi = "10.1016/j.electacta.2009.09.057"
}

Damljanovic, I., Vukicevic, M., Manojlović, D. D., Šojić, N., Buriez, O.,& Vukicevic, R. D.. (2010). Electrochemical bromination of peracetylated D-glucal: Effect of DMSO on chemoselectivity. in Electrochimica Acta
Pergamon-Elsevier Science Ltd, Oxford., 55(3), 965-969.
https://doi.org/10.1016/j.electacta.2009.09.057

Damljanovic I, Vukicevic M, Manojlović DD, Šojić N, Buriez O, Vukicevic RD. Electrochemical bromination of peracetylated D-glucal: Effect of DMSO on chemoselectivity. in Electrochimica Acta. 2010;55(3):965-969.
doi:10.1016/j.electacta.2009.09.057 .

Damljanovic, Ivan, Vukicevic, Mirjana, Manojlović, Dragan D., Šojić, Nešo, Buriez, Olivier, Vukicevic, Rastko D., "Electrochemical bromination of peracetylated D-glucal: Effect of DMSO on chemoselectivity" in Electrochimica Acta, 55, no. 3 (2010):965-969,
https://doi.org/10.1016/j.electacta.2009.09.057 . .