TY  - JOUR
AU  - Krstić, Milena P.
AU  - Petković, Branka B.
AU  - Milčić, Miloš K.
AU  - Mišić, Dušan R.
AU  - Francisco Santibanez, Juan
PY  - 2019
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3689
AB  - Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231.
PB  - SOC CHEMISTS TECHNOLOGISTS MADECONIA
T2  - Macedonian Journal of Chemistry and Chemical Engineering
T1  - Synthesis, Characterization and Biological Study of New Dinuclear Zinc(ii) and Nickel(ii) Octaaza Macrocyclic Complexes
VL  - 38
IS  - 1
SP  - 1
EP  - 11
DO  - 10.20450/mjcce.2019.1599
ER  - 

@article{
author = "Krstić, Milena P. and Petković, Branka B. and Milčić, Miloš K. and Mišić, Dušan R. and Francisco Santibanez, Juan",
year = "2019",
abstract = "Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231.",
publisher = "SOC CHEMISTS TECHNOLOGISTS MADECONIA",
journal = "Macedonian Journal of Chemistry and Chemical Engineering",
title = "Synthesis, Characterization and Biological Study of New Dinuclear Zinc(ii) and Nickel(ii) Octaaza Macrocyclic Complexes",
volume = "38",
number = "1",
pages = "1-11",
doi = "10.20450/mjcce.2019.1599"
}

Krstić, M. P., Petković, B. B., Milčić, M. K., Mišić, D. R.,& Francisco Santibanez, J.. (2019). Synthesis, Characterization and Biological Study of New Dinuclear Zinc(ii) and Nickel(ii) Octaaza Macrocyclic Complexes. in Macedonian Journal of Chemistry and Chemical Engineering
SOC CHEMISTS TECHNOLOGISTS MADECONIA., 38(1), 1-11.
https://doi.org/10.20450/mjcce.2019.1599

Krstić MP, Petković BB, Milčić MK, Mišić DR, Francisco Santibanez J. Synthesis, Characterization and Biological Study of New Dinuclear Zinc(ii) and Nickel(ii) Octaaza Macrocyclic Complexes. in Macedonian Journal of Chemistry and Chemical Engineering. 2019;38(1):1-11.
doi:10.20450/mjcce.2019.1599 .

Krstić, Milena P., Petković, Branka B., Milčić, Miloš K., Mišić, Dušan R., Francisco Santibanez, Juan, "Synthesis, Characterization and Biological Study of New Dinuclear Zinc(ii) and Nickel(ii) Octaaza Macrocyclic Complexes" in Macedonian Journal of Chemistry and Chemical Engineering, 38, no. 1 (2019):1-11,
https://doi.org/10.20450/mjcce.2019.1599 . .

TY  - THES
AU  - Kovačić, Marijana
PY  - 2018
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=6759
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:19632/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=51340815
UR  - http://nardus.mpn.gov.rs/123456789/11051
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/3161
AB  - Бронхопнеумонија је најчешће обољење телади у свету али до данас нијеразјашњено зашто имунски систем телади не одговара ефикасно на узрочникебронхопнеумоније. Вируси и бактерије узрочници бронхопнемоније сукоменсали и изазивају болест само када је имунолошка одбрана слаба, која кодтелади настаје због незрелости имунског система и изложености стресуузрокованом неповољним временским приликама и смештајем у слабовентилиране, пренасељене и влажне објекте. Како је ово обољење узрок великихекономских губитака на говедарским фармама постоји велика потреба да сепроблем овог обољења реши.Имајући у виду да је имунитет телета на неке од узрочникабронхопнеумоније посредован IgG антителима и да би имунокомплекси које оваантитела формирају могли да учествују у патогенези бронхопнеумоније, овадокторска дисертација је за циљ имала испитивање протеинских и липиднихкомпоненти циркулишућих имунокомплекса (CIC) телади старих три месеца,оболелих од бронхопнеумонијe изазване бактеријом Pasteurella multocida,најчешћим узрочником болести на фармама у околини Београда, и испитивањеулоге CIC као модулатора функција ћелија имунског одговора.У овој докторској дисертацији CIC су изоловани преципитацијомпротеина крвног серума полиетилен гликолом. Ниво CIC телади сабронхопнеумонијом је у односу на здраву телад био повећан. CIC телади сабронпнеумонијом су били већи. У CIC обе групе телади на основухидродинамичког радијуса издваја се пет група честица; у CIC болесне теладинајзаступљеније су биле честице од 1426±291 nm; а у CIC здраве телади честицехидродинамичког радијуса од 225±33 nm и 734±174 nm. Зета потенцијал CICтелади са бронхопнеумонијом је био незнатно већи од зета потенцијала CICздраве телади.У серумима телади са бронхопнеумонијом детектован је повишен нивоукупних протеина...
AB  - Bronchopneumonia is the most frequent cause of calves’ ailments around theworld. The absence of adequate immune response to causative agents ofbronchopneumonia in calves remained unclear to date. The infectious agents of virusand/or bacterium origin associated with bronchopneumonia are omnipresent harmlesscommensals in the cattle population that induce illness when the host defense isdepressed by environmental stress factors and inability of calves to fully respond to anantigenic stimulus due to the fragile nature of the immune system. The disease is aleading cause of economic loss in the livestock industry worldwide which points to thenecessity of attending to this problem with great attention.Having in mind that immune response to certain pathogens responsible forbronchopneumonia in calves is IgG antibody-dependent, the presence of immunecomplexes containing these antibodies could have an important role in the pathogenesisof bronchopneumonia. The goal of this doctoral dissertation was to investigate theprotein and lipid components of circulating immune complexes (CIC) of calves threemonths old, diagnosed with bronchopneumonia caused by Pasteurella multocidabacterium, and their role as modulators of immune response.CIC were isolated by polyethylene glycol precipitation. The level ofpolyethylene glycol precipitating CIC in calves with bronchopneumonia compared tohealthy calves was higher. In calves with bronchopneumonia CIC were larger in size.CIC were composed of five groups of corpuscles; In healthy calves the most abundantcorpuscles in CIC were of 1426±291 nm in diameter; In healthy calves corpuscles withhydrodynamic radius of 225±33 nm and 734±174 nm were mostly present in CIC. Incalves with bronchopneumonia zeta potential of CIC was slightly higher than zetapotential of CIC in healthy calves.In calves with bronchopneumonia increased level of serum total proteins wasdetected. The concentration of γ and α globulins in the serum and in CIC of diseasedcalves was higher. The concentration of IgG and transferrin in the sera was higher, butremained unchanged in CIC of diseased calves...
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Структурне и функционалне особине имунокомплекса код телади оболеле од бронхопнеумоније
UR  - https://hdl.handle.net/21.15107/rcub_nardus_11051
ER  - 

@phdthesis{
author = "Kovačić, Marijana",
year = "2018",
abstract = "Бронхопнеумонија је најчешће обољење телади у свету али до данас нијеразјашњено зашто имунски систем телади не одговара ефикасно на узрочникебронхопнеумоније. Вируси и бактерије узрочници бронхопнемоније сукоменсали и изазивају болест само када је имунолошка одбрана слаба, која кодтелади настаје због незрелости имунског система и изложености стресуузрокованом неповољним временским приликама и смештајем у слабовентилиране, пренасељене и влажне објекте. Како је ово обољење узрок великихекономских губитака на говедарским фармама постоји велика потреба да сепроблем овог обољења реши.Имајући у виду да је имунитет телета на неке од узрочникабронхопнеумоније посредован IgG антителима и да би имунокомплекси које оваантитела формирају могли да учествују у патогенези бронхопнеумоније, овадокторска дисертација је за циљ имала испитивање протеинских и липиднихкомпоненти циркулишућих имунокомплекса (CIC) телади старих три месеца,оболелих од бронхопнеумонијe изазване бактеријом Pasteurella multocida,најчешћим узрочником болести на фармама у околини Београда, и испитивањеулоге CIC као модулатора функција ћелија имунског одговора.У овој докторској дисертацији CIC су изоловани преципитацијомпротеина крвног серума полиетилен гликолом. Ниво CIC телади сабронхопнеумонијом је у односу на здраву телад био повећан. CIC телади сабронпнеумонијом су били већи. У CIC обе групе телади на основухидродинамичког радијуса издваја се пет група честица; у CIC болесне теладинајзаступљеније су биле честице од 1426±291 nm; а у CIC здраве телади честицехидродинамичког радијуса од 225±33 nm и 734±174 nm. Зета потенцијал CICтелади са бронхопнеумонијом је био незнатно већи од зета потенцијала CICздраве телади.У серумима телади са бронхопнеумонијом детектован је повишен нивоукупних протеина..., Bronchopneumonia is the most frequent cause of calves’ ailments around theworld. The absence of adequate immune response to causative agents ofbronchopneumonia in calves remained unclear to date. The infectious agents of virusand/or bacterium origin associated with bronchopneumonia are omnipresent harmlesscommensals in the cattle population that induce illness when the host defense isdepressed by environmental stress factors and inability of calves to fully respond to anantigenic stimulus due to the fragile nature of the immune system. The disease is aleading cause of economic loss in the livestock industry worldwide which points to thenecessity of attending to this problem with great attention.Having in mind that immune response to certain pathogens responsible forbronchopneumonia in calves is IgG antibody-dependent, the presence of immunecomplexes containing these antibodies could have an important role in the pathogenesisof bronchopneumonia. The goal of this doctoral dissertation was to investigate theprotein and lipid components of circulating immune complexes (CIC) of calves threemonths old, diagnosed with bronchopneumonia caused by Pasteurella multocidabacterium, and their role as modulators of immune response.CIC were isolated by polyethylene glycol precipitation. The level ofpolyethylene glycol precipitating CIC in calves with bronchopneumonia compared tohealthy calves was higher. In calves with bronchopneumonia CIC were larger in size.CIC were composed of five groups of corpuscles; In healthy calves the most abundantcorpuscles in CIC were of 1426±291 nm in diameter; In healthy calves corpuscles withhydrodynamic radius of 225±33 nm and 734±174 nm were mostly present in CIC. Incalves with bronchopneumonia zeta potential of CIC was slightly higher than zetapotential of CIC in healthy calves.In calves with bronchopneumonia increased level of serum total proteins wasdetected. The concentration of γ and α globulins in the serum and in CIC of diseasedcalves was higher. The concentration of IgG and transferrin in the sera was higher, butremained unchanged in CIC of diseased calves...",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Структурне и функционалне особине имунокомплекса код телади оболеле од бронхопнеумоније",
url = "https://hdl.handle.net/21.15107/rcub_nardus_11051"
}

Kovačić, M.. (2018). Структурне и функционалне особине имунокомплекса код телади оболеле од бронхопнеумоније. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_11051

Kovačić M. Структурне и функционалне особине имунокомплекса код телади оболеле од бронхопнеумоније. in Универзитет у Београду. 2018;.
https://hdl.handle.net/21.15107/rcub_nardus_11051 .

Kovačić, Marijana, "Структурне и функционалне особине имунокомплекса код телади оболеле од бронхопнеумоније" in Универзитет у Београду (2018),
https://hdl.handle.net/21.15107/rcub_nardus_11051 .

TY  - JOUR
AU  - Dimitrijevic, R.
AU  - Stojanovic, M.
AU  - Micic, M.
AU  - Dimitrijevic, Lj
AU  - Gavrović-Jankulović, Marija
PY  - 2012
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1310
AB  - To explore the potential usage of recombinant banana lectin as an immunostimulator it was of interest to analyze the effect it exerted in vivo in mice, upon two different routes of exposure. By Western blotting analysis of the gastric and intestinal luminal content it was found that recombinant banana lectin is stable in vivo in the mouse digestive tract, where it specifically interacts with the mucosal surfaces which can be inhibited by the addition of glucose. Its attachment to mice jejunum has been confirmed by immunofluorescence. In addition, it was able to induce systemic immunity, evidenced by specific antibody production, by oral application, a property that might be exploited for the induction of systemic immune responses. (c) 2012 Elsevier Ltd. All rights reserved.
PB  - Elsevier Science Bv, Amsterdam
T2  - Journal of Functional Foods
T1  - Recombinant banana lectin as mucosal immunostimulator
VL  - 4
IS  - 3
SP  - 636
EP  - 641
DO  - 10.1016/j.jff.2012.04.003
ER  - 

@article{
author = "Dimitrijevic, R. and Stojanovic, M. and Micic, M. and Dimitrijevic, Lj and Gavrović-Jankulović, Marija",
year = "2012",
abstract = "To explore the potential usage of recombinant banana lectin as an immunostimulator it was of interest to analyze the effect it exerted in vivo in mice, upon two different routes of exposure. By Western blotting analysis of the gastric and intestinal luminal content it was found that recombinant banana lectin is stable in vivo in the mouse digestive tract, where it specifically interacts with the mucosal surfaces which can be inhibited by the addition of glucose. Its attachment to mice jejunum has been confirmed by immunofluorescence. In addition, it was able to induce systemic immunity, evidenced by specific antibody production, by oral application, a property that might be exploited for the induction of systemic immune responses. (c) 2012 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of Functional Foods",
title = "Recombinant banana lectin as mucosal immunostimulator",
volume = "4",
number = "3",
pages = "636-641",
doi = "10.1016/j.jff.2012.04.003"
}

Dimitrijevic, R., Stojanovic, M., Micic, M., Dimitrijevic, L.,& Gavrović-Jankulović, M.. (2012). Recombinant banana lectin as mucosal immunostimulator. in Journal of Functional Foods
Elsevier Science Bv, Amsterdam., 4(3), 636-641.
https://doi.org/10.1016/j.jff.2012.04.003

Dimitrijevic R, Stojanovic M, Micic M, Dimitrijevic L, Gavrović-Jankulović M. Recombinant banana lectin as mucosal immunostimulator. in Journal of Functional Foods. 2012;4(3):636-641.
doi:10.1016/j.jff.2012.04.003 .

Dimitrijevic, R., Stojanovic, M., Micic, M., Dimitrijevic, Lj, Gavrović-Jankulović, Marija, "Recombinant banana lectin as mucosal immunostimulator" in Journal of Functional Foods, 4, no. 3 (2012):636-641,
https://doi.org/10.1016/j.jff.2012.04.003 . .