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Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636

Penjišević, Jelena ; Šukalović, Vladimir ; Dukić-Stefanović, Slađana; Deuther-Conrad, Winnie; Andrić, Deana ; Kostić-Rajačić, Slađana

TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana 
AU  - Kostić-Rajačić, Slađana
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 
@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana  and Kostić-Rajačić, Slađana",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}
Penjišević, J., Šukalović, V., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D.,& Kostić-Rajačić, S..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845
Penjišević J, Šukalović V, Dukić-Stefanović S, Deuther-Conrad W, Andrić D, Kostić-Rajačić S. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .
Penjišević, Jelena , Šukalović, Vladimir , Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana , Kostić-Rajačić, Slađana, "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry Royal Society of Chemistry., 21(6), 1187-1205. https://doi.org/10.1039/D2OB02119F

Aleksić, Jovana; Stojanović, Milovan; Bošković, Jakša; Baranac-Stojanović, Marija

TY  - DATA
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Bošković, Jakša
AU  - Baranac-Stojanović, Marija
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5846
AB  - We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.
PB  - Royal Society of Chemistry
T2  - Organic & Biomolecular Chemistry
T1  - Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F
VL  - 21
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5846
ER  - 
@misc{
author = "Aleksić, Jovana and Stojanović, Milovan and Bošković, Jakša and Baranac-Stojanović, Marija",
abstract = "We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.",
publisher = "Royal Society of Chemistry",
journal = "Organic & Biomolecular Chemistry",
title = "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F",
volume = "21",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5846"
}
Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M..Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846
Aleksić J, Stojanović M, Bošković J, Baranac-Stojanović M. Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry.21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846 .
Aleksić, Jovana, Stojanović, Milovan, Bošković, Jakša, Baranac-Stojanović, Marija, "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F" in Organic & Biomolecular Chemistry, 21, no. 6,
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

Synthesis and characterization of Cu(II)‑meso-HMPAO complex as a model for the development of potential 64Cu radiopharmaceutical

Mirković, Marija; Belaj, Ferdinand; Perić, Marko; Stanković, Dalibor; Radović, Magdalena; Milanović, Zorana; Vranješ-Đurić, Sanja; Janković, Drina; Cvijetić, Ilija; Mihajlović-Lalić, Ljiljana E.

(Elsevier, 2025)

TY  - JOUR
AU  - Mirković, Marija
AU  - Belaj, Ferdinand
AU  - Perić, Marko
AU  - Stanković, Dalibor
AU  - Radović, Magdalena
AU  - Milanović, Zorana
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
AU  - Cvijetić, Ilija
AU  - Mihajlović-Lalić, Ljiljana E.
PY  - 2025
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6636
AB  - In this work, Cu(II) complexes with meso‑HMPAO and d,l-HMPAO were synthesized. The structural characterisation of the isolated compounds has been done by single-crystal X-ray diffraction analysis, FTIR, and mass spectroscopy. Redox properties of complexes and binding to deoxyribonucleic acid (DNA) molecule have been analysed in detail by cyclic voltammetry and DFT calculations. The results of cyclic voltammetry fully agree with the data obtained by DFT calculations and indicate that the first electron removal takes place from the metal, while the second electron is removed from the ligand. The formation of the complex leads to the shift in oxidation peaks of the ligand from ‒0.29 V to 0,47 V and from 1.18 V to 1,24 V, indicating that ligand in the complex is much more difficult to oxidize. Electrochemical data confirmed the binding between the complex and DNA molecules through guanine. DFT calculations show that the complex is suitable not only for binding purine and pyrimidine bases through a coordination bond but also for additional hydrogen and CH-π interactions of the bases with the ligand. The fluorescence titration experiments revealed a moderate binding affinity of the [Cu-HMPAO]ClO4 complex to human serum albumin (HSA). Molecular docking revealed that this ligand preferentially binds to drug binding site 3 of HSA. Therefore, the novel compounds could be of great interest for further investigation, considering the potential anticancer activity, and as a model for the development of radiopharmaceutical with 64Cu.
PB  - Elsevier
T2  - Journal of Molecular Structure
T2  - Journal of Molecular Structure
T1  - Synthesis and characterization of Cu(II)‑meso-HMPAO complex as a model for the development of potential 64Cu radiopharmaceutical
VL  - 1321
SP  - 139791
DO  - 10.1016/j.molstruc.2024.139791
ER  - 
@article{
author = "Mirković, Marija and Belaj, Ferdinand and Perić, Marko and Stanković, Dalibor and Radović, Magdalena and Milanović, Zorana and Vranješ-Đurić, Sanja and Janković, Drina and Cvijetić, Ilija and Mihajlović-Lalić, Ljiljana E.",
year = "2025",
abstract = "In this work, Cu(II) complexes with meso‑HMPAO and d,l-HMPAO were synthesized. The structural characterisation of the isolated compounds has been done by single-crystal X-ray diffraction analysis, FTIR, and mass spectroscopy. Redox properties of complexes and binding to deoxyribonucleic acid (DNA) molecule have been analysed in detail by cyclic voltammetry and DFT calculations. The results of cyclic voltammetry fully agree with the data obtained by DFT calculations and indicate that the first electron removal takes place from the metal, while the second electron is removed from the ligand. The formation of the complex leads to the shift in oxidation peaks of the ligand from ‒0.29 V to 0,47 V and from 1.18 V to 1,24 V, indicating that ligand in the complex is much more difficult to oxidize. Electrochemical data confirmed the binding between the complex and DNA molecules through guanine. DFT calculations show that the complex is suitable not only for binding purine and pyrimidine bases through a coordination bond but also for additional hydrogen and CH-π interactions of the bases with the ligand. The fluorescence titration experiments revealed a moderate binding affinity of the [Cu-HMPAO]ClO4 complex to human serum albumin (HSA). Molecular docking revealed that this ligand preferentially binds to drug binding site 3 of HSA. Therefore, the novel compounds could be of great interest for further investigation, considering the potential anticancer activity, and as a model for the development of radiopharmaceutical with 64Cu.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure, Journal of Molecular Structure",
title = "Synthesis and characterization of Cu(II)‑meso-HMPAO complex as a model for the development of potential 64Cu radiopharmaceutical",
volume = "1321",
pages = "139791",
doi = "10.1016/j.molstruc.2024.139791"
}
Mirković, M., Belaj, F., Perić, M., Stanković, D., Radović, M., Milanović, Z., Vranješ-Đurić, S., Janković, D., Cvijetić, I.,& Mihajlović-Lalić, L. E.. (2025). Synthesis and characterization of Cu(II)‑meso-HMPAO complex as a model for the development of potential 64Cu radiopharmaceutical. in Journal of Molecular Structure
Elsevier., 1321, 139791.
https://doi.org/10.1016/j.molstruc.2024.139791
Mirković M, Belaj F, Perić M, Stanković D, Radović M, Milanović Z, Vranješ-Đurić S, Janković D, Cvijetić I, Mihajlović-Lalić LE. Synthesis and characterization of Cu(II)‑meso-HMPAO complex as a model for the development of potential 64Cu radiopharmaceutical. in Journal of Molecular Structure. 2025;1321:139791.
doi:10.1016/j.molstruc.2024.139791 .
Mirković, Marija, Belaj, Ferdinand, Perić, Marko, Stanković, Dalibor, Radović, Magdalena, Milanović, Zorana, Vranješ-Đurić, Sanja, Janković, Drina, Cvijetić, Ilija, Mihajlović-Lalić, Ljiljana E., "Synthesis and characterization of Cu(II)‑meso-HMPAO complex as a model for the development of potential 64Cu radiopharmaceutical" in Journal of Molecular Structure, 1321 (2025):139791,
https://doi.org/10.1016/j.molstruc.2024.139791 . .

Electrochemistry of different ruthenium polypyridine complexes

Nikolić, Stefan; Stanković, Dalibor; Grgurić-Šipka, Sanja

(Elsevier, 2025)

TY  - JOUR
AU  - Nikolić, Stefan
AU  - Stanković, Dalibor
AU  - Grgurić-Šipka, Sanja
PY  - 2025
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6647
AB  - In search for antitumor metal-based drugs that would mitigate the severe side-effects of cisplatin, Ru(II) complexes
are gaining increasing recent interest. Their cytotoxic effect is widely known, however mechanism of
action, solution behavior, redox reactions within biological system are still focus of the new studies. Various
experiments and approach techniques are used to better understand ruthenium chemistry. In this order their
biological activity and the availability of reduction potential in the biological medium, it is necessary to know
their electrochemical redox behavior and properties. In this work, we report the electrochemical activity on
synthesized and characterized (1H- and 13C NMR, FT-IR, MS) half-sandwich organometallic Ru(II) complexes of
the general formula [Ru(η6-arene)(XY)Cl](PF6) where arene = benzene, toluene or p-cymene and XY = bidentates:
dipyrido[3,2-a:2′,3′-c]phenazine (dppz derivatives) or 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline
(aip), which are bound to Ru(II) via two phenanthroline-N atoms in a characteristic “piano-stool”
configuration of Ru(II)-arene complexes – as confirmed by vibrational and NMR spectra. It is shown that selected
complexes can be divided in four groups, based on their electrochemical behavior. These behaviors are correlated
with their structure and nature of ligands.
PB  - Elsevier
T2  - Inorganica Chimica Acta
T1  - Electrochemistry of different ruthenium polypyridine complexes
VL  - 574
SP  - 122352
DO  - 10.1016/j.ica.2024.122352
ER  - 
@article{
author = "Nikolić, Stefan and Stanković, Dalibor and Grgurić-Šipka, Sanja",
year = "2025",
abstract = "In search for antitumor metal-based drugs that would mitigate the severe side-effects of cisplatin, Ru(II) complexes
are gaining increasing recent interest. Their cytotoxic effect is widely known, however mechanism of
action, solution behavior, redox reactions within biological system are still focus of the new studies. Various
experiments and approach techniques are used to better understand ruthenium chemistry. In this order their
biological activity and the availability of reduction potential in the biological medium, it is necessary to know
their electrochemical redox behavior and properties. In this work, we report the electrochemical activity on
synthesized and characterized (1H- and 13C NMR, FT-IR, MS) half-sandwich organometallic Ru(II) complexes of
the general formula [Ru(η6-arene)(XY)Cl](PF6) where arene = benzene, toluene or p-cymene and XY = bidentates:
dipyrido[3,2-a:2′,3′-c]phenazine (dppz derivatives) or 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline
(aip), which are bound to Ru(II) via two phenanthroline-N atoms in a characteristic “piano-stool”
configuration of Ru(II)-arene complexes – as confirmed by vibrational and NMR spectra. It is shown that selected
complexes can be divided in four groups, based on their electrochemical behavior. These behaviors are correlated
with their structure and nature of ligands.",
publisher = "Elsevier",
journal = "Inorganica Chimica Acta",
title = "Electrochemistry of different ruthenium polypyridine complexes",
volume = "574",
pages = "122352",
doi = "10.1016/j.ica.2024.122352"
}
Nikolić, S., Stanković, D.,& Grgurić-Šipka, S.. (2025). Electrochemistry of different ruthenium polypyridine complexes. in Inorganica Chimica Acta
Elsevier., 574, 122352.
https://doi.org/10.1016/j.ica.2024.122352
Nikolić S, Stanković D, Grgurić-Šipka S. Electrochemistry of different ruthenium polypyridine complexes. in Inorganica Chimica Acta. 2025;574:122352.
doi:10.1016/j.ica.2024.122352 .
Nikolić, Stefan, Stanković, Dalibor, Grgurić-Šipka, Sanja, "Electrochemistry of different ruthenium polypyridine complexes" in Inorganica Chimica Acta, 574 (2025):122352,
https://doi.org/10.1016/j.ica.2024.122352 . .

Optimizacija ekstrakcije sekundarnih metabolita iz kurkume primenom prirodnih eutektičkih smeša

Večerina, Suzana

(2024)

TY  - THES
AU  - Večerina, Suzana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6659
AB  - Konvencionalne metode ekstrakcije zahtevaju upotrebu organskih rastvarača, što nosi rizike po životnu sredinu i zdravlje analitičara, čineći ih potencijalno opasnim i ekološki neodrživim. Stoga, zeleni rastvarači predstavljaju efikasnu alternativu tradicionalnim rastvaračima, a među njima istakli su se prirodni eutektički rastvarači (Natural Deep Eutectic Solvents, NADES). Kurkumin, sekundarni metabolit kurkume odgovoran za karakterističnu žutu boju, ispoljava širok spektar bioloških aktivnosti, kao što su antioksidativna, antiinflamatorna, antitumorska i antibakterijska aktivnost.
U okviru ovog rada ispitana je antioksidativna aktivnost i sposobnost inhibicije enzima tirozinaze i amilaze 20 zelenih ekstrakata kurkume (Curcuma longa L.) dobijenih ekstrakcijom prirodnim eutektičkim smešama. Efikasnost ekstrakcije biljnih metabolita primenom NADES rastvarača je poređena sa ekstrakcijom konvencionalnim rastvaračima kao što su etanol i voda korišćenjem DPPH i ABTS testova, kao i testa za određivanje ukupnog sadržaja polifenola. Na osnovu dobijenih rezultata zaključeno je da zeleni ekstrakti dobijeni upotrebom NADES rastvarača predstavljaju efikasnu alternativu i bogat izvor biološki aktivnih jedinjenja, kao i da poseduju izražen antioksidativni potencijal. Kao najaktivniji pokazali su se NADES ekstrakti kurkume dobijeni ekstrakcijom rastvaračem izgrađenim od holin-hlorida i limunske kiseline.
T1  - Optimizacija ekstrakcije sekundarnih metabolita iz kurkume primenom prirodnih eutektičkih smeša
SP  - 1
EP  - 45
ER  - 
@mastersthesis{
author = "Večerina, Suzana",
year = "2024",
abstract = "Konvencionalne metode ekstrakcije zahtevaju upotrebu organskih rastvarača, što nosi rizike po životnu sredinu i zdravlje analitičara, čineći ih potencijalno opasnim i ekološki neodrživim. Stoga, zeleni rastvarači predstavljaju efikasnu alternativu tradicionalnim rastvaračima, a među njima istakli su se prirodni eutektički rastvarači (Natural Deep Eutectic Solvents, NADES). Kurkumin, sekundarni metabolit kurkume odgovoran za karakterističnu žutu boju, ispoljava širok spektar bioloških aktivnosti, kao što su antioksidativna, antiinflamatorna, antitumorska i antibakterijska aktivnost.
U okviru ovog rada ispitana je antioksidativna aktivnost i sposobnost inhibicije enzima tirozinaze i amilaze 20 zelenih ekstrakata kurkume (Curcuma longa L.) dobijenih ekstrakcijom prirodnim eutektičkim smešama. Efikasnost ekstrakcije biljnih metabolita primenom NADES rastvarača je poređena sa ekstrakcijom konvencionalnim rastvaračima kao što su etanol i voda korišćenjem DPPH i ABTS testova, kao i testa za određivanje ukupnog sadržaja polifenola. Na osnovu dobijenih rezultata zaključeno je da zeleni ekstrakti dobijeni upotrebom NADES rastvarača predstavljaju efikasnu alternativu i bogat izvor biološki aktivnih jedinjenja, kao i da poseduju izražen antioksidativni potencijal. Kao najaktivniji pokazali su se NADES ekstrakti kurkume dobijeni ekstrakcijom rastvaračem izgrađenim od holin-hlorida i limunske kiseline.",
title = "Optimizacija ekstrakcije sekundarnih metabolita iz kurkume primenom prirodnih eutektičkih smeša",
pages = "1-45"
}
Večerina, S.. (2024). Optimizacija ekstrakcije sekundarnih metabolita iz kurkume primenom prirodnih eutektičkih smeša. , 1-45.
Večerina S. Optimizacija ekstrakcije sekundarnih metabolita iz kurkume primenom prirodnih eutektičkih smeša. 2024;:1-45..
Večerina, Suzana, "Optimizacija ekstrakcije sekundarnih metabolita iz kurkume primenom prirodnih eutektičkih smeša" (2024):1-45.

Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage

Jednak Berić, Tanja; Vrvić, Miroslav; Lješević, Marija; Avdalović, Jelena; Ilić, Mila; Crnković, Dragan; Jovančićević, Branimir; Miletić, Srđan

(CSIRO Publishing, 2024)

TY  - JOUR
AU  - Jednak Berić, Tanja
AU  - Vrvić, Miroslav
AU  - Lješević, Marija
AU  - Avdalović, Jelena
AU  - Ilić, Mila
AU  - Crnković, Dragan
AU  - Jovančićević, Branimir
AU  - Miletić, Srđan
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6579
AB  - Environmental contextMitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents.RationaleBioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies.MethodologyIn this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction.ResultsIn our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased.DiscussionThe sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.
PB  - CSIRO Publishing
T2  - Environmental Chemistry
T1  - Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage
VL  - 21
IS  - 5
SP  - EN23111
DO  - 10.1071/EN23111
ER  - 
@article{
author = "Jednak Berić, Tanja and Vrvić, Miroslav and Lješević, Marija and Avdalović, Jelena and Ilić, Mila and Crnković, Dragan and Jovančićević, Branimir and Miletić, Srđan",
year = "2024",
abstract = "Environmental contextMitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents.RationaleBioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies.MethodologyIn this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction.ResultsIn our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased.DiscussionThe sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.",
publisher = "CSIRO Publishing",
journal = "Environmental Chemistry",
title = "Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage",
volume = "21",
number = "5",
pages = "EN23111",
doi = "10.1071/EN23111"
}
Jednak Berić, T., Vrvić, M., Lješević, M., Avdalović, J., Ilić, M., Crnković, D., Jovančićević, B.,& Miletić, S.. (2024). Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. in Environmental Chemistry
CSIRO Publishing., 21(5), EN23111.
https://doi.org/10.1071/EN23111
Jednak Berić T, Vrvić M, Lješević M, Avdalović J, Ilić M, Crnković D, Jovančićević B, Miletić S. Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. in Environmental Chemistry. 2024;21(5):EN23111.
doi:10.1071/EN23111 .
Jednak Berić, Tanja, Vrvić, Miroslav, Lješević, Marija, Avdalović, Jelena, Ilić, Mila, Crnković, Dragan, Jovančićević, Branimir, Miletić, Srđan, "Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage" in Environmental Chemistry, 21, no. 5 (2024):EN23111,
https://doi.org/10.1071/EN23111 . .

Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes

Petrović, Tamara; Dimitrijević, Marija; Mihajlović-Lalić, Ljiljana; Stanković, Dalibor; Vlahović, Filip; Grgurić-Šipka, Sanja; Mihajilov-Krstev, Tatjana; Miladinović, Dragoljub; Poljarević, Jelena

(Taylor & Francis, 2024)

TY  - JOUR
AU  - Petrović, Tamara
AU  - Dimitrijević, Marija
AU  - Mihajlović-Lalić, Ljiljana
AU  - Stanković, Dalibor
AU  - Vlahović, Filip
AU  - Grgurić-Šipka, Sanja
AU  - Mihajilov-Krstev, Tatjana
AU  - Miladinović, Dragoljub
AU  - Poljarević, Jelena
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6568
AB  - Eight new ruthenium complexes (C1, C2 (Ru-benzene or Ru-toluene complexes with L1, 3
amino-2-chloropyridine); C3, C4 (Ru-benzene or Ru-toluene complexes with L2, 2-amino-5
chloropyridine); C5, C6 (Ru-benzene or Ru-toluene complexes with L3, 3-acetylpyridine); and 
C7, C8 (Ru-benzene or Ru-toluene complexes with L4, 4-acetylpyridine) were synthesized. The 
chemical structures and purity of synthesized compounds were confirmed using standard 
analytical methods such as 1H, 13C NMR and IR spectroscopy, mass spectrometry, and elemental 
analysis, and their electrochemical behavior was evaluated using cyclic voltammetry 
experiments. The stability of synthesized compounds in dimethyl sulfoxide solution was 
confirmed using 1H NMR spectroscopy. Finally, the antimicrobial potential of two complex 
precursors (CP1, [Ru(η6-benzene)Cl(μ-Cl)]2  and CP2, [Ru(η6-toluene)Cl(μ-Cl)]2), four ligands 
(L1 – L4), and eight corresponding complexes (C1 – C8) was screened against nine pathogenic 
microorganisms and two reference bacterial strains, using the micro-well dilution method. The 
highest antibacterial activity (0.63 mg/mL) exerted C5 against S. aureus, B. cereus, E. coli, and 
S. enteritidis, while complex C8 displayed more pronounced antimicrobial activity against C. 
albicans (MIC/MMC = 0.31 mg/mL). Subsequently, the studied complexes underwent a detailed 
examination utilizing the DFT methodology, acquiring important quantum-chemical descriptors. 
Notably, the HOMO-LUMO gap was established as a significant correlate with the antimicrobial 
activity of synthesized compounds.
PB  - Taylor & Francis
T2  - Journal of Coordination Chemistry
T1  - Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes
VL  - 77
IS  - 7-8
SP  - 750
EP  - 765
DO  - 10.1080/00958972.2024.2307911
ER  - 
@article{
author = "Petrović, Tamara and Dimitrijević, Marija and Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Vlahović, Filip and Grgurić-Šipka, Sanja and Mihajilov-Krstev, Tatjana and Miladinović, Dragoljub and Poljarević, Jelena",
year = "2024",
abstract = "Eight new ruthenium complexes (C1, C2 (Ru-benzene or Ru-toluene complexes with L1, 3
amino-2-chloropyridine); C3, C4 (Ru-benzene or Ru-toluene complexes with L2, 2-amino-5
chloropyridine); C5, C6 (Ru-benzene or Ru-toluene complexes with L3, 3-acetylpyridine); and 
C7, C8 (Ru-benzene or Ru-toluene complexes with L4, 4-acetylpyridine) were synthesized. The 
chemical structures and purity of synthesized compounds were confirmed using standard 
analytical methods such as 1H, 13C NMR and IR spectroscopy, mass spectrometry, and elemental 
analysis, and their electrochemical behavior was evaluated using cyclic voltammetry 
experiments. The stability of synthesized compounds in dimethyl sulfoxide solution was 
confirmed using 1H NMR spectroscopy. Finally, the antimicrobial potential of two complex 
precursors (CP1, [Ru(η6-benzene)Cl(μ-Cl)]2  and CP2, [Ru(η6-toluene)Cl(μ-Cl)]2), four ligands 
(L1 – L4), and eight corresponding complexes (C1 – C8) was screened against nine pathogenic 
microorganisms and two reference bacterial strains, using the micro-well dilution method. The 
highest antibacterial activity (0.63 mg/mL) exerted C5 against S. aureus, B. cereus, E. coli, and 
S. enteritidis, while complex C8 displayed more pronounced antimicrobial activity against C. 
albicans (MIC/MMC = 0.31 mg/mL). Subsequently, the studied complexes underwent a detailed 
examination utilizing the DFT methodology, acquiring important quantum-chemical descriptors. 
Notably, the HOMO-LUMO gap was established as a significant correlate with the antimicrobial 
activity of synthesized compounds.",
publisher = "Taylor & Francis",
journal = "Journal of Coordination Chemistry",
title = "Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes",
volume = "77",
number = "7-8",
pages = "750-765",
doi = "10.1080/00958972.2024.2307911"
}
Petrović, T., Dimitrijević, M., Mihajlović-Lalić, L., Stanković, D., Vlahović, F., Grgurić-Šipka, S., Mihajilov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2024). Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry
Taylor & Francis., 77(7-8), 750-765.
https://doi.org/10.1080/00958972.2024.2307911
Petrović T, Dimitrijević M, Mihajlović-Lalić L, Stanković D, Vlahović F, Grgurić-Šipka S, Mihajilov-Krstev T, Miladinović D, Poljarević J. Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry. 2024;77(7-8):750-765.
doi:10.1080/00958972.2024.2307911 .
Petrović, Tamara, Dimitrijević, Marija, Mihajlović-Lalić, Ljiljana, Stanković, Dalibor, Vlahović, Filip, Grgurić-Šipka, Sanja, Mihajilov-Krstev, Tatjana, Miladinović, Dragoljub, Poljarević, Jelena, "Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes" in Journal of Coordination Chemistry, 77, no. 7-8 (2024):750-765,
https://doi.org/10.1080/00958972.2024.2307911 . .

Oxorhenium(V) complexes with pyridinedicarboxylic ligands: Synthesis, density functional theory calculations, and drug combination study

Petrović, Tamara; Gligorijević, Nevenka; Medaković, Vesna; Veljković, Dušan; Aranđelović, Sandra; Grgurić-Šipka, Sanja; Poljarević, Jelena

(Wiley, 2024)

TY  - JOUR
AU  - Petrović, Tamara
AU  - Gligorijević, Nevenka
AU  - Medaković, Vesna
AU  - Veljković, Dušan
AU  - Aranđelović, Sandra
AU  - Grgurić-Šipka, Sanja
AU  - Poljarević, Jelena
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6608
AB  - Three oxorhenium(V) complexes [ReOLCl2(PPh3)] (C1–C3) were synthesized
 in the reaction of 2,3-pyridinedicarboxylic acid (HL1), 2,5-pyridinedicarboxylic
 acid (HL2), and 2,6-pyridinedicarboxylic acid (HL3) with [ReOCl3(PPh3)2].
 Chemical structures of synthesized compounds were confirmed using standard
 analytical techniques. The most stable geometry of complexes was proposed
 using density functional theory calculations. The antiproliferative activity of
 the synthesized complexes was evaluated in a panel of human tumor cell lines
 (A549, PANC-1, OVCAR-3, and MDA-MB-231) and in one nontumor cell line
 (MRC-5), in comparison with the activity of cisplatin as a reference drug. The
 complex C3 exhibited the highest antiproliferative potential in PANC-1 cells,
 with IC50 48.73 ± 0.31 μM. Our previous research of oxorhenium(V) com
plexes suggested the involvement of drug-efflux transporter P-glycoprotein
 (Pgp) in the detoxification of rhenium complexes in pancreatic adenocarci
noma cells. In the present study, the effect of verapamil hydrochloride, the spe
cific pharmacological blocker of Pgp, was tested in combination with novel
 rhenium complexes C1–C3 or cisplatin (CDDP), in PANC-1 cells. The verapa
mil enhanced the antiproliferative activity of complex C3, indicating again the
 role of Pgp in detoxification of oxorhenium(V) complexes in highly invasive
 and resistant PANC-1 cells.
PB  - Wiley
T2  - Applied Organometallic Chemistry
T1  - Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study
VL  - 38
SP  - e7623
DO  - 10.1002/aoc.7623
ER  - 
@article{
author = "Petrović, Tamara and Gligorijević, Nevenka and Medaković, Vesna and Veljković, Dušan and Aranđelović, Sandra and Grgurić-Šipka, Sanja and Poljarević, Jelena",
year = "2024",
abstract = "Three oxorhenium(V) complexes [ReOLCl2(PPh3)] (C1–C3) were synthesized
 in the reaction of 2,3-pyridinedicarboxylic acid (HL1), 2,5-pyridinedicarboxylic
 acid (HL2), and 2,6-pyridinedicarboxylic acid (HL3) with [ReOCl3(PPh3)2].
 Chemical structures of synthesized compounds were confirmed using standard
 analytical techniques. The most stable geometry of complexes was proposed
 using density functional theory calculations. The antiproliferative activity of
 the synthesized complexes was evaluated in a panel of human tumor cell lines
 (A549, PANC-1, OVCAR-3, and MDA-MB-231) and in one nontumor cell line
 (MRC-5), in comparison with the activity of cisplatin as a reference drug. The
 complex C3 exhibited the highest antiproliferative potential in PANC-1 cells,
 with IC50 48.73 ± 0.31 μM. Our previous research of oxorhenium(V) com
plexes suggested the involvement of drug-efflux transporter P-glycoprotein
 (Pgp) in the detoxification of rhenium complexes in pancreatic adenocarci
noma cells. In the present study, the effect of verapamil hydrochloride, the spe
cific pharmacological blocker of Pgp, was tested in combination with novel
 rhenium complexes C1–C3 or cisplatin (CDDP), in PANC-1 cells. The verapa
mil enhanced the antiproliferative activity of complex C3, indicating again the
 role of Pgp in detoxification of oxorhenium(V) complexes in highly invasive
 and resistant PANC-1 cells.",
publisher = "Wiley",
journal = "Applied Organometallic Chemistry",
title = "Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study",
volume = "38",
pages = "e7623",
doi = "10.1002/aoc.7623"
}
Petrović, T., Gligorijević, N., Medaković, V., Veljković, D., Aranđelović, S., Grgurić-Šipka, S.,& Poljarević, J.. (2024). Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study. in Applied Organometallic Chemistry
Wiley., 38, e7623.
https://doi.org/10.1002/aoc.7623
Petrović T, Gligorijević N, Medaković V, Veljković D, Aranđelović S, Grgurić-Šipka S, Poljarević J. Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study. in Applied Organometallic Chemistry. 2024;38:e7623.
doi:10.1002/aoc.7623 .
Petrović, Tamara, Gligorijević, Nevenka, Medaković, Vesna, Veljković, Dušan, Aranđelović, Sandra, Grgurić-Šipka, Sanja, Poljarević, Jelena, "Oxorhenium(V) complexes with pyridinedicarboxylic  ligands: Synthesis, density functional theory calculations,  and drug combination study" in Applied Organometallic Chemistry, 38 (2024):e7623,
https://doi.org/10.1002/aoc.7623 . .

Complete degradation of propranolol by a water falling film non-thermal plasma reactor: The effects of input power and plasma gases on transformation pathway

Savić, Slađana D.; Kovačević, Vesna V.; Stanković, Dalibor M.; Sretenović, Goran B.; Vasović, Tamara D.; Vlahović, Filip Ž.; Dojčinović, BIljana P.; Obradović, Bratislav M.; Kuraica, Milorad M.; Manojlović, Dragan D.; Roglić, Goran M.

(Elsevier, 2024)

TY  - JOUR
AU  - Savić, Slađana D.
AU  - Kovačević, Vesna V.
AU  - Stanković, Dalibor M.
AU  - Sretenović, Goran B.
AU  - Vasović, Tamara D.
AU  - Vlahović, Filip Ž.
AU  - Dojčinović, BIljana P.
AU  - Obradović, Bratislav M.
AU  - Kuraica, Milorad M.
AU  - Manojlović, Dragan D.
AU  - Roglić, Goran M.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6614
AB  - Propranolol, a beta-blocker, is a widely used drug for cardiovascular diseases. A synthetic sample containing propranolol (PRO) solution at native pH was recirculated up to ten times through an original coaxial non-thermal plasma reactor with a water falling film. Different discharge conditions, feed gasses, and power greatly influenced the extent of PRO degradation and the abundance of degradation products. The highest degradation rates were achieved in Ar plasma, either pure or in a mixture with O2, with over 70% of PRO degraded after only two passes through the DBD reactor. The full non-thermal plasma treatment was followed by a minimal change of pH value and conductivity. On the other hand, ambient air as the feed gas resulted in 60% of PRO degradation rate after the full treatment and contributed to a major drop in pH value and an increase in the conductivity of the treated solution. The structures of 47 degradation products in all three gases were identified and the degradation pathway is proposed, supported by DFT methodology. Scavenging experiments demonstrated that hydroxyl radical was predominant when plasma was generated using ambient air and Ar, while it had a minimal effect on the degradation in the mixture of Ar and O2. The desired level of propranolol decomposition was achieved only by the adjustment of the nonchemical parameters of the treatment, such as plasma gas composition and power. These results imply that a non-thermal plasma reactor is a highly effective method for pharmaceutical wastewater treatment, with no catalysts added.
PB  - Elsevier
T2  - Chemical Engineering Journal
T1  - Complete degradation of propranolol by a water falling film non-thermal plasma reactor: The effects of input power and plasma gases on transformation pathway
VL  - 497
SP  - 154685
DO  - 10.1016/j.cej.2024.154685
ER  - 
@article{
author = "Savić, Slađana D. and Kovačević, Vesna V. and Stanković, Dalibor M. and Sretenović, Goran B. and Vasović, Tamara D. and Vlahović, Filip Ž. and Dojčinović, BIljana P. and Obradović, Bratislav M. and Kuraica, Milorad M. and Manojlović, Dragan D. and Roglić, Goran M.",
year = "2024",
abstract = "Propranolol, a beta-blocker, is a widely used drug for cardiovascular diseases. A synthetic sample containing propranolol (PRO) solution at native pH was recirculated up to ten times through an original coaxial non-thermal plasma reactor with a water falling film. Different discharge conditions, feed gasses, and power greatly influenced the extent of PRO degradation and the abundance of degradation products. The highest degradation rates were achieved in Ar plasma, either pure or in a mixture with O2, with over 70% of PRO degraded after only two passes through the DBD reactor. The full non-thermal plasma treatment was followed by a minimal change of pH value and conductivity. On the other hand, ambient air as the feed gas resulted in 60% of PRO degradation rate after the full treatment and contributed to a major drop in pH value and an increase in the conductivity of the treated solution. The structures of 47 degradation products in all three gases were identified and the degradation pathway is proposed, supported by DFT methodology. Scavenging experiments demonstrated that hydroxyl radical was predominant when plasma was generated using ambient air and Ar, while it had a minimal effect on the degradation in the mixture of Ar and O2. The desired level of propranolol decomposition was achieved only by the adjustment of the nonchemical parameters of the treatment, such as plasma gas composition and power. These results imply that a non-thermal plasma reactor is a highly effective method for pharmaceutical wastewater treatment, with no catalysts added.",
publisher = "Elsevier",
journal = "Chemical Engineering Journal",
title = "Complete degradation of propranolol by a water falling film non-thermal plasma reactor: The effects of input power and plasma gases on transformation pathway",
volume = "497",
pages = "154685",
doi = "10.1016/j.cej.2024.154685"
}
Savić, S. D., Kovačević, V. V., Stanković, D. M., Sretenović, G. B., Vasović, T. D., Vlahović, F. Ž., Dojčinović, B. P., Obradović, B. M., Kuraica, M. M., Manojlović, D. D.,& Roglić, G. M.. (2024). Complete degradation of propranolol by a water falling film non-thermal plasma reactor: The effects of input power and plasma gases on transformation pathway. in Chemical Engineering Journal
Elsevier., 497, 154685.
https://doi.org/10.1016/j.cej.2024.154685
Savić SD, Kovačević VV, Stanković DM, Sretenović GB, Vasović TD, Vlahović FŽ, Dojčinović BP, Obradović BM, Kuraica MM, Manojlović DD, Roglić GM. Complete degradation of propranolol by a water falling film non-thermal plasma reactor: The effects of input power and plasma gases on transformation pathway. in Chemical Engineering Journal. 2024;497:154685.
doi:10.1016/j.cej.2024.154685 .
Savić, Slađana D., Kovačević, Vesna V., Stanković, Dalibor M., Sretenović, Goran B., Vasović, Tamara D., Vlahović, Filip Ž., Dojčinović, BIljana P., Obradović, Bratislav M., Kuraica, Milorad M., Manojlović, Dragan D., Roglić, Goran M., "Complete degradation of propranolol by a water falling film non-thermal plasma reactor: The effects of input power and plasma gases on transformation pathway" in Chemical Engineering Journal, 497 (2024):154685,
https://doi.org/10.1016/j.cej.2024.154685 . .

Molekulsko obeležavanje polimera laktoferinom

Anđelković, Ilija

(2024)

TY  - THES
AU  - Anđelković, Ilija
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6658
AB  - Laktoferin je protein prirodno zastupljen u surutki mleka, ima veoma važnu ulogu u modulaciji
imunskog odgovora i učestvuje u odbrani organizma od reaktivnih kiseoničnih vrsta i
oksidativnog stresa. Studije pokazuju da određivanje koncentracije laktoferina u različitim
telesnim tečnostima ima značaj prilikom tačne dijagnostike različitih bolesti, poput akutnih
infekcija urinarnog trakta. Ovaj završi rad se bazira na sintezi različitih molekulski obeleženih
polimera laktoferinom kako bi došlo do razvoja novih matriksa za određivanje laktoferina u
telesnim tečnostima. Sintetisana su tri molekulski obeležena polimera i njihovi neobeleženi
analozi za laktoferin gde su kao funkcionalni monomeri korišćeni različiti molski ekvivalenti
metakrilne kiseline u odnosu na templat. Kao pomoćni monomer u svim polimerima korišćen
je akrilamid. Polimeri su okarakterisani infracrvenom spektroskopijom i ispitivanjem
efikasnosti vezivanja templata za različite polimere. Takođe je ispitana i selektivnost dobijenih
polimera za papain, riboflavin-vezujući protein, transferin i goveđi serum albumin. Rezultati
vezivanja pokazuju pri kom odnosu metakrilne kiseline dolazi do najvećeg efekta obeležavanja
i afiniteta polimera prema laktoferinu. Kod polimera označenog kao MOPI postignut je faktor
obeležavanja 7,27, što znači da su ovi polimeriefikasnije obeleženi proteinom u odnosu
naostale polimere. Nekovalentni pristup omogućava fleksibilnost pri uspostavljanju interakcija
između molekula templata i funkcionalnog monomera što dovodi do adekvatnog obeležavanja
polimera proteinom.
T1  - Molekulsko obeležavanje polimera laktoferinom
SP  - 1
EP  - 40
ER  - 
@misc{
author = "Anđelković, Ilija",
year = "2024",
abstract = "Laktoferin je protein prirodno zastupljen u surutki mleka, ima veoma važnu ulogu u modulaciji
imunskog odgovora i učestvuje u odbrani organizma od reaktivnih kiseoničnih vrsta i
oksidativnog stresa. Studije pokazuju da određivanje koncentracije laktoferina u različitim
telesnim tečnostima ima značaj prilikom tačne dijagnostike različitih bolesti, poput akutnih
infekcija urinarnog trakta. Ovaj završi rad se bazira na sintezi različitih molekulski obeleženih
polimera laktoferinom kako bi došlo do razvoja novih matriksa za određivanje laktoferina u
telesnim tečnostima. Sintetisana su tri molekulski obeležena polimera i njihovi neobeleženi
analozi za laktoferin gde su kao funkcionalni monomeri korišćeni različiti molski ekvivalenti
metakrilne kiseline u odnosu na templat. Kao pomoćni monomer u svim polimerima korišćen
je akrilamid. Polimeri su okarakterisani infracrvenom spektroskopijom i ispitivanjem
efikasnosti vezivanja templata za različite polimere. Takođe je ispitana i selektivnost dobijenih
polimera za papain, riboflavin-vezujući protein, transferin i goveđi serum albumin. Rezultati
vezivanja pokazuju pri kom odnosu metakrilne kiseline dolazi do najvećeg efekta obeležavanja
i afiniteta polimera prema laktoferinu. Kod polimera označenog kao MOPI postignut je faktor
obeležavanja 7,27, što znači da su ovi polimeriefikasnije obeleženi proteinom u odnosu
naostale polimere. Nekovalentni pristup omogućava fleksibilnost pri uspostavljanju interakcija
između molekula templata i funkcionalnog monomera što dovodi do adekvatnog obeležavanja
polimera proteinom.",
title = "Molekulsko obeležavanje polimera laktoferinom",
pages = "1-40"
}
Anđelković, I.. (2024). Molekulsko obeležavanje polimera laktoferinom. , 1-40.
Anđelković I. Molekulsko obeležavanje polimera laktoferinom. 2024;:1-40..
Anđelković, Ilija, "Molekulsko obeležavanje polimera laktoferinom" (2024):1-40.

Reaktivna ekstrakcija mlečne kiseline pomoću različitih ekstraktanata

Dedić, Andrej

(2024)

TY  - THES
AU  - Dedić, Andrej
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6657
AB  - Reaktivna ekstrakcija je sve ispitivanija metoda zbog svoje efikasnosti, jednostavnosti i niže cene proizvodnje. Cilj ovog rada je ispitivanje efikasnosti reaktivne ekstrakcije mlečne kiseline različitim ekstraktantima u toluenu.
Nepolarni rastvarači visokih molarnih masa su najmanje toksični po fermentacione mikroorganizme, pa je toluen izabran kao rastvarač da simulira nepolarnu sredinu iako je sam toksičan. Pored toluena urađeni su i eksperimenti sa suncokretovim uljem kao jeftinim, lako dostupnim, netoksičnim i zelenim rastvaračem kako bi se uporedila efikasnost.
Efikasnost ekstrakcije je opadala redosledom trioktilamin, adogen 464 (u daljem tekstu adogen), tributilfosfat. Reakcioni kompleksi stehiometrijskog odnosa 2:1 su primećeni kod reaktivne ekstrakcije trioktilaminom i adogenom u manjoj meri. Upotrebom trioktilamina u suncokretovom ulju umesto toluenu nije došlo do velikog smanjenja efikasnosti ekstrakciije.
T1  - Reaktivna ekstrakcija mlečne kiseline pomoću različitih ekstraktanata
SP  - 2
EP  - 33
ER  - 
@misc{
author = "Dedić, Andrej",
year = "2024",
abstract = "Reaktivna ekstrakcija je sve ispitivanija metoda zbog svoje efikasnosti, jednostavnosti i niže cene proizvodnje. Cilj ovog rada je ispitivanje efikasnosti reaktivne ekstrakcije mlečne kiseline različitim ekstraktantima u toluenu.
Nepolarni rastvarači visokih molarnih masa su najmanje toksični po fermentacione mikroorganizme, pa je toluen izabran kao rastvarač da simulira nepolarnu sredinu iako je sam toksičan. Pored toluena urađeni su i eksperimenti sa suncokretovim uljem kao jeftinim, lako dostupnim, netoksičnim i zelenim rastvaračem kako bi se uporedila efikasnost.
Efikasnost ekstrakcije je opadala redosledom trioktilamin, adogen 464 (u daljem tekstu adogen), tributilfosfat. Reakcioni kompleksi stehiometrijskog odnosa 2:1 su primećeni kod reaktivne ekstrakcije trioktilaminom i adogenom u manjoj meri. Upotrebom trioktilamina u suncokretovom ulju umesto toluenu nije došlo do velikog smanjenja efikasnosti ekstrakciije.",
title = "Reaktivna ekstrakcija mlečne kiseline pomoću različitih ekstraktanata",
pages = "2-33"
}
Dedić, A.. (2024). Reaktivna ekstrakcija mlečne kiseline pomoću različitih ekstraktanata. , 2-33.
Dedić A. Reaktivna ekstrakcija mlečne kiseline pomoću različitih ekstraktanata. 2024;:2-33..
Dedić, Andrej, "Reaktivna ekstrakcija mlečne kiseline pomoću različitih ekstraktanata" (2024):2-33.

Izolovanje i određivanje strukture glikozilovanog flavonola iz biljne vrste Euphorbia amygdaloides

Spasenović, Anastasija

(2024)

TY  - THES
AU  - Spasenović, Anastasija
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6656
AB  - Biljna vrsta Euphorbia amygdaloides pripada rodu Euphorbia (familija Euphorbiaceae). Biljke roda Euphorbia primenjuju se u tradicionalnoj medicini zbog svojih farmakoloških dejstava. U lateksu i drugim delovima ovih biljaka nalazi se veliki broj sekundarnih metabolita za koje je dokazano da poseduju određene biološke aktivosti, kao što su anti-kancerogene, anti-virusne, anti-inflamatorne, DNK-protektivne i dr.
Cilj ovog rada bio je ispitivanje sekundarnih metabolita biljne vrste E. amygdaloides. U toku ovog ispitivanja iz ekstrakta biljne vrste je izolovan i okarakterisan kvercetin-3-O-α-D-arabinopiranozid.
T1  - Izolovanje i određivanje strukture glikozilovanog flavonola iz biljne vrste Euphorbia amygdaloides
SP  - 1
EP  - 20
ER  - 
@misc{
author = "Spasenović, Anastasija",
year = "2024",
abstract = "Biljna vrsta Euphorbia amygdaloides pripada rodu Euphorbia (familija Euphorbiaceae). Biljke roda Euphorbia primenjuju se u tradicionalnoj medicini zbog svojih farmakoloških dejstava. U lateksu i drugim delovima ovih biljaka nalazi se veliki broj sekundarnih metabolita za koje je dokazano da poseduju određene biološke aktivosti, kao što su anti-kancerogene, anti-virusne, anti-inflamatorne, DNK-protektivne i dr.
Cilj ovog rada bio je ispitivanje sekundarnih metabolita biljne vrste E. amygdaloides. U toku ovog ispitivanja iz ekstrakta biljne vrste je izolovan i okarakterisan kvercetin-3-O-α-D-arabinopiranozid.",
title = "Izolovanje i određivanje strukture glikozilovanog flavonola iz biljne vrste Euphorbia amygdaloides",
pages = "1-20"
}
Spasenović, A.. (2024). Izolovanje i određivanje strukture glikozilovanog flavonola iz biljne vrste Euphorbia amygdaloides. , 1-20.
Spasenović A. Izolovanje i određivanje strukture glikozilovanog flavonola iz biljne vrste Euphorbia amygdaloides. 2024;:1-20..
Spasenović, Anastasija, "Izolovanje i određivanje strukture glikozilovanog flavonola iz biljne vrste Euphorbia amygdaloides" (2024):1-20.

Ispitivanje koordinativnih i redoks interakcija tenoksikama sa Fe3+ jonima u vodi na različitim pH

Petrović, Aleksandra

(2024)

TY  - THES
AU  - Petrović, Aleksandra
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6655
AB  - Tenoksikam (TNX) (4-hidroksi-2-metil-1,1-diokso-N-piridin-2-iltieno[2,3-e]tiazin 3-karboksamid) pokazuje analgetsko, antipiretičko i anti-inflamatorno dejstvo i primenjuje se oralno. TNX sadrži dve jonizabilne grupe i heteroatome dostupne za koordinaciju sa jonima različitih metala. U ovom radu ispitivane su koordinacione i redoks interakcije TNX sa Fe3+ jonima u vodi UV-Vis i fluorescentnom spektroskopijom i cikličnom votametrijom (CV). Formiranje TNX-Fe3+ kompleksa se dešava na kiselim pH vrednostima (pH 2, pH 4 i pH 5). U neutralnom vodenom rastvoru (pH 7) nije detektovano formiranje TNX-Fe3+ kompleksa. CV merenja su urađena na pH 5 u cilju ispitivanja redoks osobina TNX u prisustvu Fe3+ jona. Redoks osobine TNX u prisustvu Fe3+ jona zavise od molskog odnosa TNX i Fe3+ jona.
T1  - Ispitivanje koordinativnih i redoks interakcija tenoksikama sa Fe3+ jonima u vodi na različitim pH
SP  - 1
EP  - 24
ER  - 
@misc{
author = "Petrović, Aleksandra",
year = "2024",
abstract = "Tenoksikam (TNX) (4-hidroksi-2-metil-1,1-diokso-N-piridin-2-iltieno[2,3-e]tiazin 3-karboksamid) pokazuje analgetsko, antipiretičko i anti-inflamatorno dejstvo i primenjuje se oralno. TNX sadrži dve jonizabilne grupe i heteroatome dostupne za koordinaciju sa jonima različitih metala. U ovom radu ispitivane su koordinacione i redoks interakcije TNX sa Fe3+ jonima u vodi UV-Vis i fluorescentnom spektroskopijom i cikličnom votametrijom (CV). Formiranje TNX-Fe3+ kompleksa se dešava na kiselim pH vrednostima (pH 2, pH 4 i pH 5). U neutralnom vodenom rastvoru (pH 7) nije detektovano formiranje TNX-Fe3+ kompleksa. CV merenja su urađena na pH 5 u cilju ispitivanja redoks osobina TNX u prisustvu Fe3+ jona. Redoks osobine TNX u prisustvu Fe3+ jona zavise od molskog odnosa TNX i Fe3+ jona.",
title = "Ispitivanje koordinativnih i redoks interakcija tenoksikama sa Fe3+ jonima u vodi na različitim pH",
pages = "1-24"
}
Petrović, A.. (2024). Ispitivanje koordinativnih i redoks interakcija tenoksikama sa Fe3+ jonima u vodi na različitim pH. , 1-24.
Petrović A. Ispitivanje koordinativnih i redoks interakcija tenoksikama sa Fe3+ jonima u vodi na različitim pH. 2024;:1-24..
Petrović, Aleksandra, "Ispitivanje koordinativnih i redoks interakcija tenoksikama sa Fe3+ jonima u vodi na različitim pH" (2024):1-24.

Ispitivanje uticaja molskog udela monomera na obeležavanje polimera prokainom

Dakić, Aleksa

(2024)

TY  - THES
AU  - Dakić, Aleksa
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6654
AB  - Cilj ovog rada je sinteza molekulski obeleženih polimera (MOPa), za prokain, koristeći različite odnose monomera i umreživača, radi ispitivanja uticaja na uspešnost obeležavanja polimera. I pored toga što se molekulskim obeležavanjem mogu dobiti materijali visokog afiniteta i selektivnosti za određene analite, postoji niz ograničenja koja su prikazana u ovom radu. Prokain je efikasan lokalni anestetik koji se koristi za blokiranje nervnih impulsa, naročito u stomatologiji i pri manjim hirurškim procedurama. Iako se prokain smatra supstancom male toksičnosti, realna šansa za predoziranjem postoji, a simptomi podrazumevaju mučninu i respiratone probleme, dok u retkim situacijama predoziranje može dovesti i do anafilaktičkog šoka i smrti (Zhu et al., 2021). Stoga se javlja potreba za sintezom MOPa za prokain koji bi omogućili, kako jednostavnu i pouzdanu dijagnostiku njegove koncentracije u telesnim tečnostima i tkivima, pomoću elektrohemijskih metoda detekcije, tako i sistem koji omogućava produženi efekat delovanja supstance, oslanjajući se na sposobnost nekih tipova MOPa za kontrolisano oslobađanje templata u dužem vremenskom periodu.
U okviru ovog završnog rada sintetisano je 10 polimera: 5 molekulski obeleženih i 5 neobeleženih polimera. Ispitano je vezivanje prokaina za dobijene polimere, konstruisane su adsorpcione izoterme. Na osnovu podataka dobijenih iz izotermi određeni su kapaciteti i konstante vezivanja prokaina za dobijene polimere. Takođe je ispitana i selektivnost sintetisanih polimera prema prokainu u odnosu na dva strukturno slična amina, propranolol i karvedilol. Ustanovljeno je da je najpovoljniji odnos za efikasnost procesa obeležavanja, odnos templata, monomera i umreživača 1:3:20.
T1  - Ispitivanje uticaja molskog udela monomera na obeležavanje polimera prokainom
SP  - 1
EP  - 58
ER  - 
@misc{
author = "Dakić, Aleksa",
year = "2024",
abstract = "Cilj ovog rada je sinteza molekulski obeleženih polimera (MOPa), za prokain, koristeći različite odnose monomera i umreživača, radi ispitivanja uticaja na uspešnost obeležavanja polimera. I pored toga što se molekulskim obeležavanjem mogu dobiti materijali visokog afiniteta i selektivnosti za određene analite, postoji niz ograničenja koja su prikazana u ovom radu. Prokain je efikasan lokalni anestetik koji se koristi za blokiranje nervnih impulsa, naročito u stomatologiji i pri manjim hirurškim procedurama. Iako se prokain smatra supstancom male toksičnosti, realna šansa za predoziranjem postoji, a simptomi podrazumevaju mučninu i respiratone probleme, dok u retkim situacijama predoziranje može dovesti i do anafilaktičkog šoka i smrti (Zhu et al., 2021). Stoga se javlja potreba za sintezom MOPa za prokain koji bi omogućili, kako jednostavnu i pouzdanu dijagnostiku njegove koncentracije u telesnim tečnostima i tkivima, pomoću elektrohemijskih metoda detekcije, tako i sistem koji omogućava produženi efekat delovanja supstance, oslanjajući se na sposobnost nekih tipova MOPa za kontrolisano oslobađanje templata u dužem vremenskom periodu.
U okviru ovog završnog rada sintetisano je 10 polimera: 5 molekulski obeleženih i 5 neobeleženih polimera. Ispitano je vezivanje prokaina za dobijene polimere, konstruisane su adsorpcione izoterme. Na osnovu podataka dobijenih iz izotermi određeni su kapaciteti i konstante vezivanja prokaina za dobijene polimere. Takođe je ispitana i selektivnost sintetisanih polimera prema prokainu u odnosu na dva strukturno slična amina, propranolol i karvedilol. Ustanovljeno je da je najpovoljniji odnos za efikasnost procesa obeležavanja, odnos templata, monomera i umreživača 1:3:20.",
title = "Ispitivanje uticaja molskog udela monomera na obeležavanje polimera prokainom",
pages = "1-58"
}
Dakić, A.. (2024). Ispitivanje uticaja molskog udela monomera na obeležavanje polimera prokainom. , 1-58.
Dakić A. Ispitivanje uticaja molskog udela monomera na obeležavanje polimera prokainom. 2024;:1-58..
Dakić, Aleksa, "Ispitivanje uticaja molskog udela monomera na obeležavanje polimera prokainom" (2024):1-58.

Uticaj agregacije na potenciometrijsko i spektrofotometrijsko određivanje pKa vrednosti pantoprazola i rabeprazola

Selaković, Željana

(2024)

TY  - THES
AU  - Selaković, Željana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6653
AB  - Cilj ovog završnog rada bio je ispitivanje uticaja agregacije na određivanje kiselinskih konstati. Kiselinske konstante dva inhibitora protonskih pumpi: pantoprazol-natrijuma i rabeprazol-natrijuma, za koje je prema strukturi pretpostavljeno da se u rastvoru mogu dimerizovati, određene su upotrebom dve nezavisne metode, spektrofotometrije i potenciometrije. 
Vrednost konstanti kiselosti određena je potenciometrijski pomoću pSOL titratora, a eksperimentalno dobijene vrednosti obrađene su u pS programu (pION Inc, SAD). Titracije su izvedene u smeši metanol-voda (maseni udeo (wt%) MeOH: 41,2 za PaNa; 15,8 i 53,1 za RaNa). U predloženi model uključene su reakcije jonizacije a dobijene vrednosti za pantoprazol-natrijum iznose pKa1=3,41±0,03, pKa2=6,81±0,02 i pKa3=8,84±0,12. Vrednosti dobijene za rabeprazol-natrijum iznose: pKa1=3,16±0,07, pKa2=3,68±0,04 i pKa3=6,03±0,03 (wt% MeOH 15,8), a u rastvoru u kom je wt% MeOH 53,1 vrednosti konstanti iznose:  pKa1=4,98±0,06, pKa2=6,11±0,04 i pKa3=7,49±0,40.
Paralelno, urađena je UV/Vis spektrofotometrijska titracija pantoprazol-natrijuma i rabeprazol-natrijuma u smeši koja sadrži različite odnose 10 mM vodenog rastvora fosfatnog pufera i metanola rastvorom NaOH. Koncentracija jedinjenja je iznosila 1,00×10-5 M. Obradom spektrofotometrijskih podataka dobijene su vrednosti kiselinskih konstanti (pKa1) koje iznose za PaNa 1,68±0,17 (wt% MeOH 0), 1,91±0,02 (wt% MeOH 16,5), 2,67±0,05 (wt% MeOH 34,5) i 4,26±0,15 (wt% MeOH 54,2); za RaNa 2,11±0,03 (wt% MeOH 0), 2,11±0,12 (wt% MeOH 16,5), 2,21±0,23 (wt% MeOH 34,5) i 2,48±0,11 (wt% MeOH 54,2).
Na osnovu vrednosti kiselinskih konstanti dobijenih primenom spektrofotometrije zaključeno je da sa smanjenjem dielektrične konstante rastvarača raste vrednost kiselinske konstante što nije u skladu sa očekivanim trendom promene pKa vrednosti. Ovo odstupanje je značajno izraženije u slučaju pantoprazola i može se objasniti mogućim procesom agregacije. U slučaju rabeprazola takođe postoji odstupanje ali je znatno a razlike u dobijenim pKa vrednostima su pre posledica određivanja u različitoj sredini nego eventualnog procesa agregacije.
T1  - Uticaj agregacije na potenciometrijsko i spektrofotometrijsko određivanje pKa vrednosti pantoprazola i rabeprazola
SP  - 1
EP  - 41
ER  - 
@mastersthesis{
author = "Selaković, Željana",
year = "2024",
abstract = "Cilj ovog završnog rada bio je ispitivanje uticaja agregacije na određivanje kiselinskih konstati. Kiselinske konstante dva inhibitora protonskih pumpi: pantoprazol-natrijuma i rabeprazol-natrijuma, za koje je prema strukturi pretpostavljeno da se u rastvoru mogu dimerizovati, određene su upotrebom dve nezavisne metode, spektrofotometrije i potenciometrije. 
Vrednost konstanti kiselosti određena je potenciometrijski pomoću pSOL titratora, a eksperimentalno dobijene vrednosti obrađene su u pS programu (pION Inc, SAD). Titracije su izvedene u smeši metanol-voda (maseni udeo (wt%) MeOH: 41,2 za PaNa; 15,8 i 53,1 za RaNa). U predloženi model uključene su reakcije jonizacije a dobijene vrednosti za pantoprazol-natrijum iznose pKa1=3,41±0,03, pKa2=6,81±0,02 i pKa3=8,84±0,12. Vrednosti dobijene za rabeprazol-natrijum iznose: pKa1=3,16±0,07, pKa2=3,68±0,04 i pKa3=6,03±0,03 (wt% MeOH 15,8), a u rastvoru u kom je wt% MeOH 53,1 vrednosti konstanti iznose:  pKa1=4,98±0,06, pKa2=6,11±0,04 i pKa3=7,49±0,40.
Paralelno, urađena je UV/Vis spektrofotometrijska titracija pantoprazol-natrijuma i rabeprazol-natrijuma u smeši koja sadrži različite odnose 10 mM vodenog rastvora fosfatnog pufera i metanola rastvorom NaOH. Koncentracija jedinjenja je iznosila 1,00×10-5 M. Obradom spektrofotometrijskih podataka dobijene su vrednosti kiselinskih konstanti (pKa1) koje iznose za PaNa 1,68±0,17 (wt% MeOH 0), 1,91±0,02 (wt% MeOH 16,5), 2,67±0,05 (wt% MeOH 34,5) i 4,26±0,15 (wt% MeOH 54,2); za RaNa 2,11±0,03 (wt% MeOH 0), 2,11±0,12 (wt% MeOH 16,5), 2,21±0,23 (wt% MeOH 34,5) i 2,48±0,11 (wt% MeOH 54,2).
Na osnovu vrednosti kiselinskih konstanti dobijenih primenom spektrofotometrije zaključeno je da sa smanjenjem dielektrične konstante rastvarača raste vrednost kiselinske konstante što nije u skladu sa očekivanim trendom promene pKa vrednosti. Ovo odstupanje je značajno izraženije u slučaju pantoprazola i može se objasniti mogućim procesom agregacije. U slučaju rabeprazola takođe postoji odstupanje ali je znatno a razlike u dobijenim pKa vrednostima su pre posledica određivanja u različitoj sredini nego eventualnog procesa agregacije.",
title = "Uticaj agregacije na potenciometrijsko i spektrofotometrijsko određivanje pKa vrednosti pantoprazola i rabeprazola",
pages = "1-41"
}
Selaković, Ž.. (2024). Uticaj agregacije na potenciometrijsko i spektrofotometrijsko određivanje pKa vrednosti pantoprazola i rabeprazola. , 1-41.
Selaković Ž. Uticaj agregacije na potenciometrijsko i spektrofotometrijsko određivanje pKa vrednosti pantoprazola i rabeprazola. 2024;:1-41..
Selaković, Željana, "Uticaj agregacije na potenciometrijsko i spektrofotometrijsko određivanje pKa vrednosti pantoprazola i rabeprazola" (2024):1-41.

A review of the key ingredients in industrial formulations of baby wet wipes

Petrović, Tamara; Poljarević, Jelena; Nikolić, Stefan; Stojković-Filipović, Jelena; Mihajlović-Lalić, Ljiljana

(Wiley, 2024)

TY  - JOUR
AU  - Petrović, Tamara
AU  - Poljarević, Jelena
AU  - Nikolić, Stefan
AU  - Stojković-Filipović, Jelena
AU  - Mihajlović-Lalić, Ljiljana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6646
AB  - The skin of newborns is classified as sensitive, with a higher risk of skin barrier disruption
and irritation of a diapered area. Despite dermatologist recommendations to use only water
and a cloth for cleaning, most of the population still relies on the comforts of modern
parenting, which includes intensive daily usage of baby wet wipes. Novel baby formulations
are designed following the concept of infant skin health, containing a gentle cleanser,
suitable emollient, and buffer system enabling a slightly acidic pH value and they are free
of ethyl alcohol. Thus, it is important to understand the chemical background of such a
complex liquid formulation, with emphasis on its safety. In line with this, the present paper
discusses the scientific background of various chemical compounds found in baby wipe
formulations to improve the understanding of wet wipe designs and direct them toward
more skin-friendly solutions.
PB  - Wiley
T2  - International Journal of Dermatology
T1  - A review of the key ingredients in industrial formulations of baby wet wipes
VL  - n/a
DO  - 10.1111/ijd.17351
ER  - 
@article{
author = "Petrović, Tamara and Poljarević, Jelena and Nikolić, Stefan and Stojković-Filipović, Jelena and Mihajlović-Lalić, Ljiljana",
year = "2024",
abstract = "The skin of newborns is classified as sensitive, with a higher risk of skin barrier disruption
and irritation of a diapered area. Despite dermatologist recommendations to use only water
and a cloth for cleaning, most of the population still relies on the comforts of modern
parenting, which includes intensive daily usage of baby wet wipes. Novel baby formulations
are designed following the concept of infant skin health, containing a gentle cleanser,
suitable emollient, and buffer system enabling a slightly acidic pH value and they are free
of ethyl alcohol. Thus, it is important to understand the chemical background of such a
complex liquid formulation, with emphasis on its safety. In line with this, the present paper
discusses the scientific background of various chemical compounds found in baby wipe
formulations to improve the understanding of wet wipe designs and direct them toward
more skin-friendly solutions.",
publisher = "Wiley",
journal = "International Journal of Dermatology",
title = "A review of the key ingredients in industrial formulations of baby wet wipes",
volume = "n/a",
doi = "10.1111/ijd.17351"
}
Petrović, T., Poljarević, J., Nikolić, S., Stojković-Filipović, J.,& Mihajlović-Lalić, L.. (2024). A review of the key ingredients in industrial formulations of baby wet wipes. in International Journal of Dermatology
Wiley., n/a.
https://doi.org/10.1111/ijd.17351
Petrović T, Poljarević J, Nikolić S, Stojković-Filipović J, Mihajlović-Lalić L. A review of the key ingredients in industrial formulations of baby wet wipes. in International Journal of Dermatology. 2024;n/a.
doi:10.1111/ijd.17351 .
Petrović, Tamara, Poljarević, Jelena, Nikolić, Stefan, Stojković-Filipović, Jelena, Mihajlović-Lalić, Ljiljana, "A review of the key ingredients in industrial formulations of baby wet wipes" in International Journal of Dermatology, n/a (2024),
https://doi.org/10.1111/ijd.17351 . .

Ispitivanje uticaja mešanja i mućkanja suspenzije na rastvorljivost ibuprofena i nortriptilin-hidrohlorida

Matić, Dušica

(2024)

TY  - THES
AU  - Matić, Dušica
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6650
AB  - Rastvorljivost predstavlja maksimalnu količinu supstance koja se može rastvoriti u određenoj zapremini odgovarajućeg rastvarača. Rastvorljivost je važan fizičko-hemijski parametar koji utiče na biodostupnost biološki aktivnih jedinjenja. Jedan od najvaţnijih aspekata u dizajnu i razvoju lekova je upravo povećanje rastvorljivosti i biodostupnosti biološki aktivnih jedinjenja.
Cilj ovog rada bio je ispitivanje uticaja načina mešanja na rastvorljiovst lekova, konkretno ibuprofena, kao predstavnika kiselina, i nortriptilina, kao predstavnika baza (u obliku nortriptilin-hidrohlorida). Ibuprofen je derivat propionske kiseline i koristi se kao analgetik. Nortriptilin-hidrohlorid spada u grupu tricikličnih antidepresiva i koristi se u lečenju depresije.
Na rastvorljivost supstance utiče dosta faktora. Među najvažnijim su pH vrednost, sastav čvrste faze, temperatura, jonska sila, puferi, vreme uspostavljanja ravnoteže, kao i način razdvajanja faza prilikom određivanja rastvroljivosti. U ovom radu ispitivan je uticaj načina uspostavljanja ravnoteže u heterogenom sistemu mešanjem ili mućkanjem na rastvorljivost ispitivanih supstanci. pH-Zavisna rastvorljivost pomenutih lekova proučavana je primenom pH-Ramp shake-flask metode, mešanjem na magnetnoj mešalici i mućkanjem na rotatoru. Koncentracija supstanci u rastvoru, nakon uspostavljanja stabilne ravnoteže i nakon razdvajanja faza, određena je primenom UV/VIS spektrofotometrije, dok su vrednosti ravnotežnih konstanti (logS, logS0, logK2) određene pomoću programa pDISOL-X.
Analizom dobijenih razultata primećeno je da su vrednosti sopstvene rastvorljivosti više u kojim su uzorci mućkani u odnosu na uzorke koji su mešani, ali razlika nije statistički značajna. Primećeno je i da je preciznost dobijenih rezultata prilikom određivanja rastvorljivosti uz mućkanje neznatno veća u odnosu na određivanje uz mešanje. Na osnovu dobijenih rezultata može se zaključiti da način mešanja/mućkanja ne utiče značajnije na određivanje rastvorljivost u slučaju ibuprofena i nortriptilina (u obliku nortriptilin-hidrohlorida).
T1  - Ispitivanje uticaja mešanja i mućkanja suspenzije na rastvorljivost ibuprofena i nortriptilin-hidrohlorida
SP  - 1
EP  - 49
ER  - 
@mastersthesis{
author = "Matić, Dušica",
year = "2024",
abstract = "Rastvorljivost predstavlja maksimalnu količinu supstance koja se može rastvoriti u određenoj zapremini odgovarajućeg rastvarača. Rastvorljivost je važan fizičko-hemijski parametar koji utiče na biodostupnost biološki aktivnih jedinjenja. Jedan od najvaţnijih aspekata u dizajnu i razvoju lekova je upravo povećanje rastvorljivosti i biodostupnosti biološki aktivnih jedinjenja.
Cilj ovog rada bio je ispitivanje uticaja načina mešanja na rastvorljiovst lekova, konkretno ibuprofena, kao predstavnika kiselina, i nortriptilina, kao predstavnika baza (u obliku nortriptilin-hidrohlorida). Ibuprofen je derivat propionske kiseline i koristi se kao analgetik. Nortriptilin-hidrohlorid spada u grupu tricikličnih antidepresiva i koristi se u lečenju depresije.
Na rastvorljivost supstance utiče dosta faktora. Među najvažnijim su pH vrednost, sastav čvrste faze, temperatura, jonska sila, puferi, vreme uspostavljanja ravnoteže, kao i način razdvajanja faza prilikom određivanja rastvroljivosti. U ovom radu ispitivan je uticaj načina uspostavljanja ravnoteže u heterogenom sistemu mešanjem ili mućkanjem na rastvorljivost ispitivanih supstanci. pH-Zavisna rastvorljivost pomenutih lekova proučavana je primenom pH-Ramp shake-flask metode, mešanjem na magnetnoj mešalici i mućkanjem na rotatoru. Koncentracija supstanci u rastvoru, nakon uspostavljanja stabilne ravnoteže i nakon razdvajanja faza, određena je primenom UV/VIS spektrofotometrije, dok su vrednosti ravnotežnih konstanti (logS, logS0, logK2) određene pomoću programa pDISOL-X.
Analizom dobijenih razultata primećeno je da su vrednosti sopstvene rastvorljivosti više u kojim su uzorci mućkani u odnosu na uzorke koji su mešani, ali razlika nije statistički značajna. Primećeno je i da je preciznost dobijenih rezultata prilikom određivanja rastvorljivosti uz mućkanje neznatno veća u odnosu na određivanje uz mešanje. Na osnovu dobijenih rezultata može se zaključiti da način mešanja/mućkanja ne utiče značajnije na određivanje rastvorljivost u slučaju ibuprofena i nortriptilina (u obliku nortriptilin-hidrohlorida).",
title = "Ispitivanje uticaja mešanja i mućkanja suspenzije na rastvorljivost ibuprofena i nortriptilin-hidrohlorida",
pages = "1-49"
}
Matić, D.. (2024). Ispitivanje uticaja mešanja i mućkanja suspenzije na rastvorljivost ibuprofena i nortriptilin-hidrohlorida. , 1-49.
Matić D. Ispitivanje uticaja mešanja i mućkanja suspenzije na rastvorljivost ibuprofena i nortriptilin-hidrohlorida. 2024;:1-49..
Matić, Dušica, "Ispitivanje uticaja mešanja i mućkanja suspenzije na rastvorljivost ibuprofena i nortriptilin-hidrohlorida" (2024):1-49.

Graphene quantum dots with covalently bonded gold nanoparticles winning the battle against methicillin-resistant Staphylococcus aureus under blue light

Dorontic, Sladjana; Jovanovic, Svetlana; Stefanovic, Andjela; Kepic, Dejan; Scopelliti, Michelangelo; Ciasca, Gabriele; Di Santo, Riccardo; Bajuk Bogdanovic, Danica; Marković, Olivera; Todorovic Markovic, Biljana; Markovic, Zoran

(Elsevier, 2024)

TY  - JOUR
AU  - Dorontic, Sladjana
AU  - Jovanovic, Svetlana
AU  - Stefanovic, Andjela
AU  - Kepic, Dejan
AU  - Scopelliti, Michelangelo
AU  - Ciasca, Gabriele
AU  - Di Santo, Riccardo
AU  - Bajuk Bogdanovic, Danica
AU  - Marković, Olivera
AU  - Todorovic Markovic, Biljana
AU  - Markovic, Zoran
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6649
AB  - Over the last decades, bacterial resistance has become one of the emerging health threats. Particularly dangerous
are bacterial strains resistant to various antibacterial drugs. Herein, we modified graphene quantum dots (GQDs)
to produce efficient photo-induced antibacterial agents. GQDs were modified with (a) ethylene-diamine (EDA),
(b) with EDA and gold nanoparticles (AuNPs), and (c) 3-amino-1,2,4-triazole (TA) using carbodiimide coupling.
Photo-induced antibacterial activity of modified GQDs was tested against 8 bacterial strains. Treatment with
modified GQDs and blue light (wavelength of 470 nm) resulted in remarkable antibacterial activity with minimal
inhibitory concentrations (MIC) of 7.81 μg mL-1 for K. pneumoniae and S. aureus and 3.9 μg mL -1 against MRSA
and E. faecalis. Planar organization of GQDs functionalized with AuNPs allowed direct access of molecular oxygen
to AuNPs leading to more efficient 1O2 production as well as the 1O2 production from excited GQDs. Thus,
GQDs functionalized with AuNPs showed outstanding efficiency in the battle against several bacterial strains,
particularly those that lead to nosocomial infections.
PB  - Elsevier
T2  - Synthetic Metals
T1  - Graphene quantum dots with covalently bonded gold nanoparticles winning the battle against methicillin-resistant Staphylococcus aureus under blue light
VL  - 309
SP  - 117753
DO  - 10.1016/j.synthmet.2024.117753
ER  - 
@article{
author = "Dorontic, Sladjana and Jovanovic, Svetlana and Stefanovic, Andjela and Kepic, Dejan and Scopelliti, Michelangelo and Ciasca, Gabriele and Di Santo, Riccardo and Bajuk Bogdanovic, Danica and Marković, Olivera and Todorovic Markovic, Biljana and Markovic, Zoran",
year = "2024",
abstract = "Over the last decades, bacterial resistance has become one of the emerging health threats. Particularly dangerous
are bacterial strains resistant to various antibacterial drugs. Herein, we modified graphene quantum dots (GQDs)
to produce efficient photo-induced antibacterial agents. GQDs were modified with (a) ethylene-diamine (EDA),
(b) with EDA and gold nanoparticles (AuNPs), and (c) 3-amino-1,2,4-triazole (TA) using carbodiimide coupling.
Photo-induced antibacterial activity of modified GQDs was tested against 8 bacterial strains. Treatment with
modified GQDs and blue light (wavelength of 470 nm) resulted in remarkable antibacterial activity with minimal
inhibitory concentrations (MIC) of 7.81 μg mL-1 for K. pneumoniae and S. aureus and 3.9 μg mL -1 against MRSA
and E. faecalis. Planar organization of GQDs functionalized with AuNPs allowed direct access of molecular oxygen
to AuNPs leading to more efficient 1O2 production as well as the 1O2 production from excited GQDs. Thus,
GQDs functionalized with AuNPs showed outstanding efficiency in the battle against several bacterial strains,
particularly those that lead to nosocomial infections.",
publisher = "Elsevier",
journal = "Synthetic Metals",
title = "Graphene quantum dots with covalently bonded gold nanoparticles winning the battle against methicillin-resistant Staphylococcus aureus under blue light",
volume = "309",
pages = "117753",
doi = "10.1016/j.synthmet.2024.117753"
}
Dorontic, S., Jovanovic, S., Stefanovic, A., Kepic, D., Scopelliti, M., Ciasca, G., Di Santo, R., Bajuk Bogdanovic, D., Marković, O., Todorovic Markovic, B.,& Markovic, Z.. (2024). Graphene quantum dots with covalently bonded gold nanoparticles winning the battle against methicillin-resistant Staphylococcus aureus under blue light. in Synthetic Metals
Elsevier., 309, 117753.
https://doi.org/10.1016/j.synthmet.2024.117753
Dorontic S, Jovanovic S, Stefanovic A, Kepic D, Scopelliti M, Ciasca G, Di Santo R, Bajuk Bogdanovic D, Marković O, Todorovic Markovic B, Markovic Z. Graphene quantum dots with covalently bonded gold nanoparticles winning the battle against methicillin-resistant Staphylococcus aureus under blue light. in Synthetic Metals. 2024;309:117753.
doi:10.1016/j.synthmet.2024.117753 .
Dorontic, Sladjana, Jovanovic, Svetlana, Stefanovic, Andjela, Kepic, Dejan, Scopelliti, Michelangelo, Ciasca, Gabriele, Di Santo, Riccardo, Bajuk Bogdanovic, Danica, Marković, Olivera, Todorovic Markovic, Biljana, Markovic, Zoran, "Graphene quantum dots with covalently bonded gold nanoparticles winning the battle against methicillin-resistant Staphylococcus aureus under blue light" in Synthetic Metals, 309 (2024):117753,
https://doi.org/10.1016/j.synthmet.2024.117753 . .

Позитрон - 34

Шишаковић, Исидора; Мирковић, Ања; Радовановић, Мина; Крмпота, Ивана; Савић, Слађана; Тинтор, Ђорђо; Шкиљевић, Романа

(Универзитет у Београду – Хемијски факултет, 2024)

TY  - GEN
AU  - Шишаковић, Исидора
AU  - Мирковић, Ања
AU  - Радовановић, Мина
AU  - Крмпота, Ивана
AU  - Савић, Слађана
AU  - Тинтор, Ђорђо
AU  - Шкиљевић, Романа
PY  - 2024
UR  - http://chem.bg.ac.rs/studorg/
UR  - https://www.facebook.com/pozitroncasopis/
UR  - https://www.instagram.com/pozitroncasopis/
UR  - pozitron@chem.bg.ac.rs
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6652
AB  - Овај број отварамо текстом о фотобиореакторима, а у тексту који га прати се упознајемо са хемијом која стоји иза успешности злочина описаних у романима Агате Кристи. Завирите у чудесни свет нековалентних интеракција и сазнајте више о Интернационалној конференцији о нековалентним интеракција у тексту Ђорђа Тинтора, студента завршне године студија Биохемије. Разговарамо са др Џефом Фокатном, професором и продакеном за истраживања Природно-математичког факултета у Белгији који је познат као краљ GCxGC-MS анализе. Мастер студенткиња Романа Шкиљевић нам представља стартап свет кроз текст о ,,Стартап викенду“ одржаном у мају ове године у Новом Саду. У овом броју вам представљамо и пројекат MET-EFFECT којим руководи др Љиљана Михајловић Лалић, а бави се третманом канцера и заштитом животне средине помоћу комплекса прелазних метала. Као и увек, очекује вас текст о алумнистима Хемијског факултета, а овај пут је то Марија Неимаревић, наставница хемије и примењених наука у Петој београдској гимназији. На самом крају броја, пронађите информације о актуелним вестима из хемије и студентског живота на Хемијском факултету у Ретросинтези и развеселите се уз Позитиву. Уживајте!
PB  - Универзитет у Београду – Хемијски факултет
T1  - Позитрон - 34
VL  - 34
SP  - 1
EP  - 31
ER  - 
@misc{
author = "Шишаковић, Исидора and Мирковић, Ања and Радовановић, Мина and Крмпота, Ивана and Савић, Слађана and Тинтор, Ђорђо and Шкиљевић, Романа",
year = "2024",
abstract = "Овај број отварамо текстом о фотобиореакторима, а у тексту који га прати се упознајемо са хемијом која стоји иза успешности злочина описаних у романима Агате Кристи. Завирите у чудесни свет нековалентних интеракција и сазнајте више о Интернационалној конференцији о нековалентним интеракција у тексту Ђорђа Тинтора, студента завршне године студија Биохемије. Разговарамо са др Џефом Фокатном, професором и продакеном за истраживања Природно-математичког факултета у Белгији који је познат као краљ GCxGC-MS анализе. Мастер студенткиња Романа Шкиљевић нам представља стартап свет кроз текст о ,,Стартап викенду“ одржаном у мају ове године у Новом Саду. У овом броју вам представљамо и пројекат MET-EFFECT којим руководи др Љиљана Михајловић Лалић, а бави се третманом канцера и заштитом животне средине помоћу комплекса прелазних метала. Као и увек, очекује вас текст о алумнистима Хемијског факултета, а овај пут је то Марија Неимаревић, наставница хемије и примењених наука у Петој београдској гимназији. На самом крају броја, пронађите информације о актуелним вестима из хемије и студентског живота на Хемијском факултету у Ретросинтези и развеселите се уз Позитиву. Уживајте!",
publisher = "Универзитет у Београду – Хемијски факултет",
title = "Позитрон - 34",
volume = "34",
pages = "1-31"
}
Шишаковић, И., Мирковић, А., Радовановић, М., Крмпота, И., Савић, С., Тинтор, Ђ.,& Шкиљевић, Р.. (2024). Позитрон - 34. 
Универзитет у Београду – Хемијски факултет., 34, 1-31.
Шишаковић И, Мирковић А, Радовановић М, Крмпота И, Савић С, Тинтор Ђ, Шкиљевић Р. Позитрон - 34. 2024;34:1-31..
Шишаковић, Исидора, Мирковић, Ања, Радовановић, Мина, Крмпота, Ивана, Савић, Слађана, Тинтор, Ђорђо, Шкиљевић, Романа, "Позитрон - 34", 34 (2024):1-31.

Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization

Verbić, Tatjana; Marković, Olivera; Pešić, Miloš; Topalović, Igor; Đurđević, Mladen; Kuentz, Martin; Avdeef, Alex; Serajuddin, Abu

(University of Novi Sad, Faculty of Sciences, 2024)

TY  - CONF
AU  - Verbić, Tatjana
AU  - Marković, Olivera
AU  - Pešić, Miloš
AU  - Topalović, Igor
AU  - Đurđević, Mladen
AU  - Kuentz, Martin
AU  - Avdeef, Alex
AU  - Serajuddin, Abu
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6648
AB  - A majority of the new chemical entities (NCE) that emerged as potential drug candidates in pharmaceutical development during the past 2-3 decades are practically insoluble solids consisting of ionizable molecules [1]. Class II BCS drugs (Biopharmaceutics Classification System) exhibit poor bioavailability due to insufficient absorption in the gastrointestinal tract with slow drug release from the dosage forms and low solubility as the limiting steps for their absorption [2]. Thus, detailed and precise study of compound solubility and the possibilities to increase solubility and dissolution rate, are at the core of the development of bioavailable drug dosage forms and clinically effective pharmaceutical products that would dissolve in gastric and intestinal fluids after oral administration or not precipitate in the blood after intravenous administration. A white paper on consensus recommendations for improving data quality in equilibrium solubility measurement of ionizable drugs [3] emphasizes the importance of precise solubility measurements. As a part of solubility studies of a group of tricyclic antidepressants (TCAs) we have shown the influence of competing counterions, such as buffering agents, complexing agents, salt coformers, tonicity adjusters, and solid-phase transformations on the aqueous solubility of studied drugs [4-5].
A variety of methods to increase solubility and/or dissolution rate, and thereby increase their bioavailability, have been developed. Still, most of them, like particle size reduction, salt formation, conversion to amorphous form, solid dispersion, and solubilization in lipids or lipid-surfactant mixtures have their own limitations. To mitigate some of the above limitations, a novel method of drug solubilization in aqueous media by acid–base interactions has been developed [6]. This novel approach of greatly increasing the solubility is based on interactions of a model low-soluble basic drug in an aqueous medium with acidic species that would not normally form salts with it. Although quite successful, the proposed model still needs additional work and some fine-tuning with additional low-soluble drugs to establish it as a widely accepted method for increasing solubility, dissolution rate and bioavailability of poorly water-soluble drugs. Our research team is working on it.
PB  - University of Novi Sad, Faculty of Sciences
C3  - 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes, Novi Sad, Serbia, September 9 – 13, 2024
T1  - Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization
SP  - 13
EP  - 13
ER  - 
@conference{
author = "Verbić, Tatjana and Marković, Olivera and Pešić, Miloš and Topalović, Igor and Đurđević, Mladen and Kuentz, Martin and Avdeef, Alex and Serajuddin, Abu",
year = "2024",
abstract = "A majority of the new chemical entities (NCE) that emerged as potential drug candidates in pharmaceutical development during the past 2-3 decades are practically insoluble solids consisting of ionizable molecules [1]. Class II BCS drugs (Biopharmaceutics Classification System) exhibit poor bioavailability due to insufficient absorption in the gastrointestinal tract with slow drug release from the dosage forms and low solubility as the limiting steps for their absorption [2]. Thus, detailed and precise study of compound solubility and the possibilities to increase solubility and dissolution rate, are at the core of the development of bioavailable drug dosage forms and clinically effective pharmaceutical products that would dissolve in gastric and intestinal fluids after oral administration or not precipitate in the blood after intravenous administration. A white paper on consensus recommendations for improving data quality in equilibrium solubility measurement of ionizable drugs [3] emphasizes the importance of precise solubility measurements. As a part of solubility studies of a group of tricyclic antidepressants (TCAs) we have shown the influence of competing counterions, such as buffering agents, complexing agents, salt coformers, tonicity adjusters, and solid-phase transformations on the aqueous solubility of studied drugs [4-5].
A variety of methods to increase solubility and/or dissolution rate, and thereby increase their bioavailability, have been developed. Still, most of them, like particle size reduction, salt formation, conversion to amorphous form, solid dispersion, and solubilization in lipids or lipid-surfactant mixtures have their own limitations. To mitigate some of the above limitations, a novel method of drug solubilization in aqueous media by acid–base interactions has been developed [6]. This novel approach of greatly increasing the solubility is based on interactions of a model low-soluble basic drug in an aqueous medium with acidic species that would not normally form salts with it. Although quite successful, the proposed model still needs additional work and some fine-tuning with additional low-soluble drugs to establish it as a widely accepted method for increasing solubility, dissolution rate and bioavailability of poorly water-soluble drugs. Our research team is working on it.",
publisher = "University of Novi Sad, Faculty of Sciences",
journal = "21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes, Novi Sad, Serbia, September 9 – 13, 2024",
title = "Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization",
pages = "13-13"
}
Verbić, T., Marković, O., Pešić, M., Topalović, I., Đurđević, M., Kuentz, M., Avdeef, A.,& Serajuddin, A.. (2024). Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization. in 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes, Novi Sad, Serbia, September 9 – 13, 2024
University of Novi Sad, Faculty of Sciences., 13-13.
Verbić T, Marković O, Pešić M, Topalović I, Đurđević M, Kuentz M, Avdeef A, Serajuddin A. Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization. in 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes, Novi Sad, Serbia, September 9 – 13, 2024. 2024;:13-13..
Verbić, Tatjana, Marković, Olivera, Pešić, Miloš, Topalović, Igor, Đurđević, Mladen, Kuentz, Martin, Avdeef, Alex, Serajuddin, Abu, "Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization" in 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes, Novi Sad, Serbia, September 9 – 13, 2024 (2024):13-13.

Pećini metoda sinteze Ho2O3 nanočestica i njiihova primena u razvoju visoko osetljivog elektrohemijskog senzora za detekciju diurona u realnim uzorcima

Mijajlović, Aleksandar

(2024)

TY  - THES
AU  - Mijajlović, Aleksandar
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6651
AB  - Sve veći rast ljudske populacije praćen industrijalizacijom i intezivnom
poljoprivrednom proizvodnjom, povezan je sa problemima flore i faune i izaziva smanjenje
kvaliteta životne sredine, ostavljajući za sobom sve veću količinu opasnih pesticida.
U ovom radu, razvijen je novi elektrohemijski senzor za detekciju diurona (DU),
modifikujući već postojeću elektrodu od ugljenične paste (CPE) novosintetisanim Ho2O3
nanočesticama. Retki zemljini metali, kao što je Ho, sve više su popularni u razvoju novih
elektrodnih materijala zbog svojih elektrokatalitičkih performansi. Holmijum je glavni
lantanoidni element sa veoma širokim redoks-potencijalom. Sinteza Ho2O3 nanočestica urađena
je Pećini metodom sinteze, što je potvrđeno i difrakcijom X-zraka (XRD) kao i metodom
skenirajuće elektronske mikroskopije (SEM). U cilju razvoja nove metode za detekciju diurona,
ispitane su elektrokatalitičke osobine Ho2O3 modifikovane elektrode od ugljenične paste.
Elektrohemijsko ponašanje DU na novom senzoru ispitivano je koristeći cikličnu voltamteriju
(CV) kao i voltametriju pravougaonih talasa (square wave voltammetry, SWV). Senzor je
pokazao izvanredne rezultate, sa linearnim opsegom detekcije od 0.25 do 200 μM i limitom
detekcije od 0.03 μM, kao i osetljivošću od 2,14 μA μM−1 cm−2. Visoka selektivnost metode
potvrđena je analizom potencijalno interferirajućih supstanci. Dalje, CPE/Ho2O3 senzor
pokazao je veoma dobre vrednosti „recovery“-ja , pri detekciji DU u realnim uzorcima. Takođe,
praktična primena senzora u realnim uzorcima potvrđena je konvencionalnom metodom kao
što je spektrofotometrijska UV-VIS detekcija.
T1  - Pećini metoda sinteze Ho2O3 nanočestica i njiihova primena u razvoju visoko osetljivog elektrohemijskog senzora za detekciju diurona u realnim uzorcima
SP  - 1
EP  - 38
ER  - 
@mastersthesis{
author = "Mijajlović, Aleksandar",
year = "2024",
abstract = "Sve veći rast ljudske populacije praćen industrijalizacijom i intezivnom
poljoprivrednom proizvodnjom, povezan je sa problemima flore i faune i izaziva smanjenje
kvaliteta životne sredine, ostavljajući za sobom sve veću količinu opasnih pesticida.
U ovom radu, razvijen je novi elektrohemijski senzor za detekciju diurona (DU),
modifikujući već postojeću elektrodu od ugljenične paste (CPE) novosintetisanim Ho2O3
nanočesticama. Retki zemljini metali, kao što je Ho, sve više su popularni u razvoju novih
elektrodnih materijala zbog svojih elektrokatalitičkih performansi. Holmijum je glavni
lantanoidni element sa veoma širokim redoks-potencijalom. Sinteza Ho2O3 nanočestica urađena
je Pećini metodom sinteze, što je potvrđeno i difrakcijom X-zraka (XRD) kao i metodom
skenirajuće elektronske mikroskopije (SEM). U cilju razvoja nove metode za detekciju diurona,
ispitane su elektrokatalitičke osobine Ho2O3 modifikovane elektrode od ugljenične paste.
Elektrohemijsko ponašanje DU na novom senzoru ispitivano je koristeći cikličnu voltamteriju
(CV) kao i voltametriju pravougaonih talasa (square wave voltammetry, SWV). Senzor je
pokazao izvanredne rezultate, sa linearnim opsegom detekcije od 0.25 do 200 μM i limitom
detekcije od 0.03 μM, kao i osetljivošću od 2,14 μA μM−1 cm−2. Visoka selektivnost metode
potvrđena je analizom potencijalno interferirajućih supstanci. Dalje, CPE/Ho2O3 senzor
pokazao je veoma dobre vrednosti „recovery“-ja , pri detekciji DU u realnim uzorcima. Takođe,
praktična primena senzora u realnim uzorcima potvrđena je konvencionalnom metodom kao
što je spektrofotometrijska UV-VIS detekcija.",
title = "Pećini metoda sinteze Ho2O3 nanočestica i njiihova primena u razvoju visoko osetljivog elektrohemijskog senzora za detekciju diurona u realnim uzorcima",
pages = "1-38"
}
Mijajlović, A.. (2024). Pećini metoda sinteze Ho2O3 nanočestica i njiihova primena u razvoju visoko osetljivog elektrohemijskog senzora za detekciju diurona u realnim uzorcima. , 1-38.
Mijajlović A. Pećini metoda sinteze Ho2O3 nanočestica i njiihova primena u razvoju visoko osetljivog elektrohemijskog senzora za detekciju diurona u realnim uzorcima. 2024;:1-38..
Mijajlović, Aleksandar, "Pećini metoda sinteze Ho2O3 nanočestica i njiihova primena u razvoju visoko osetljivog elektrohemijskog senzora za detekciju diurona u realnim uzorcima" (2024):1-38.

Позитрон - 33

Шишаковић, Исидора; Мирковић, Ања; Радовановић, Мина; Крмпота, Ивана; Шкиљевић, Романа; Цветковић, Јован; Савић, Слађана Д.; Деновић, Вања; Симеуновић, Бојана; Арсенијевић, Марија; Лазовић, Марина; Вујновић, Милица; Ћирић, Теодора; Станков, Јелена; Јакановски, Михајло; Лазовић, Мила; Кесић, Јелена

(Универзитет у Београду – Хемијски факултет, 2024)

TY  - GEN
AU  - Шишаковић, Исидора
AU  - Мирковић, Ања
AU  - Радовановић, Мина
AU  - Крмпота, Ивана
AU  - Шкиљевић, Романа
AU  - Цветковић, Јован
AU  - Савић, Слађана Д.
AU  - Деновић, Вања
AU  - Симеуновић, Бојана
AU  - Арсенијевић, Марија
AU  - Лазовић, Марина
AU  - Вујновић, Милица
AU  - Ћирић, Теодора
AU  - Станков, Јелена
AU  - Јакановски, Михајло
AU  - Лазовић, Мила
AU  - Кесић, Јелена
PY  - 2024
UR  - http://chem.bg.ac.rs/studorg/
UR  - https://www.facebook.com/pozitroncasopis/
UR  - https://www.instagram.com/pozitroncasopis/
UR  - pozitron@chem.bg.ac.rs
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6531
AB  - На самом почетку броја, подсећамо се овогодишњеманифестације Global Women’s Breakfast, одржане у фебруару. Даље се упознајемо са радом организације Лицеулице. Студенткиња мастер студија Романа Шкиљевић представља Иновациони инкубатор, а Јован Цветковић се осврће на Дан отворених врата Хемијског факултета одржан у марту. Разговарамо са Наталијом Грујић, студенткињом Новинарства на Факултету политичких наука, а такође чланицом редакције њиховог студентског медија, Слушаонице 6, као и са студенткињом докторских академских студија у области биохемијских наука и генералном  секретарком Биохемијског друштва Србије, Исидором Протић Росић у оквиру рубрике Укратко о подугачком. У овом броју можете да откријете и нешто више о најстаријем предмету на Хемијском факултету, јеличком метеориту. Још један од наших саговорника је др Алекс Авдиф, гостујући виши сарадник на Кингс колеџу у Лондону и аутор књиге Absorption and Drug Development. Студенти Хемије животне средине нам приказују како изгледа теренска настава у оквиру изборног предмета на завршним годинама студија, Природни ресурси. Пишемо и о другом по реду Фестивалу хемије, одржаном у организацији Клуба младих хемичара Србије и Српског хемијског друштва. Препоруку за добру књигу можете да пронађете у Позитроновој листи омиљених књига, а најновије вести из хемије и студентског живота пточитајте у Ретросинтези. За крај, насмејте се кроз Позитиву и уживајте у броју пред вама.
PB  - Универзитет у Београду – Хемијски факултет
T1  - Позитрон - 33
VL  - 33
SP  - 1
EP  - 26
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6531
ER  - 
@misc{
author = "Шишаковић, Исидора and Мирковић, Ања and Радовановић, Мина and Крмпота, Ивана and Шкиљевић, Романа and Цветковић, Јован and Савић, Слађана Д. and Деновић, Вања and Симеуновић, Бојана and Арсенијевић, Марија and Лазовић, Марина and Вујновић, Милица and Ћирић, Теодора and Станков, Јелена and Јакановски, Михајло and Лазовић, Мила and Кесић, Јелена",
year = "2024",
abstract = "На самом почетку броја, подсећамо се овогодишњеманифестације Global Women’s Breakfast, одржане у фебруару. Даље се упознајемо са радом организације Лицеулице. Студенткиња мастер студија Романа Шкиљевић представља Иновациони инкубатор, а Јован Цветковић се осврће на Дан отворених врата Хемијског факултета одржан у марту. Разговарамо са Наталијом Грујић, студенткињом Новинарства на Факултету политичких наука, а такође чланицом редакције њиховог студентског медија, Слушаонице 6, као и са студенткињом докторских академских студија у области биохемијских наука и генералном  секретарком Биохемијског друштва Србије, Исидором Протић Росић у оквиру рубрике Укратко о подугачком. У овом броју можете да откријете и нешто више о најстаријем предмету на Хемијском факултету, јеличком метеориту. Још један од наших саговорника је др Алекс Авдиф, гостујући виши сарадник на Кингс колеџу у Лондону и аутор књиге Absorption and Drug Development. Студенти Хемије животне средине нам приказују како изгледа теренска настава у оквиру изборног предмета на завршним годинама студија, Природни ресурси. Пишемо и о другом по реду Фестивалу хемије, одржаном у организацији Клуба младих хемичара Србије и Српског хемијског друштва. Препоруку за добру књигу можете да пронађете у Позитроновој листи омиљених књига, а најновије вести из хемије и студентског живота пточитајте у Ретросинтези. За крај, насмејте се кроз Позитиву и уживајте у броју пред вама.",
publisher = "Универзитет у Београду – Хемијски факултет",
title = "Позитрон - 33",
volume = "33",
pages = "1-26",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6531"
}
Шишаковић, И., Мирковић, А., Радовановић, М., Крмпота, И., Шкиљевић, Р., Цветковић, Ј., Савић, С. Д., Деновић, В., Симеуновић, Б., Арсенијевић, М., Лазовић, М., Вујновић, М., Ћирић, Т., Станков, Ј., Јакановски, М., Лазовић, М.,& Кесић, Ј.. (2024). Позитрон - 33. 
Универзитет у Београду – Хемијски факултет., 33, 1-26.
https://hdl.handle.net/21.15107/rcub_cherry_6531
Шишаковић И, Мирковић А, Радовановић М, Крмпота И, Шкиљевић Р, Цветковић Ј, Савић СД, Деновић В, Симеуновић Б, Арсенијевић М, Лазовић М, Вујновић М, Ћирић Т, Станков Ј, Јакановски М, Лазовић М, Кесић Ј. Позитрон - 33. 2024;33:1-26.
https://hdl.handle.net/21.15107/rcub_cherry_6531 .
Шишаковић, Исидора, Мирковић, Ања, Радовановић, Мина, Крмпота, Ивана, Шкиљевић, Романа, Цветковић, Јован, Савић, Слађана Д., Деновић, Вања, Симеуновић, Бојана, Арсенијевић, Марија, Лазовић, Марина, Вујновић, Милица, Ћирић, Теодора, Станков, Јелена, Јакановски, Михајло, Лазовић, Мила, Кесић, Јелена, "Позитрон - 33", 33 (2024):1-26,
https://hdl.handle.net/21.15107/rcub_cherry_6531 .

Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду

Милановић Маштраповић, Весна Д.; Савић, Слађана Д.; Софренић, Ивана В.

(Београд : Српско хемијско друштво, 2024)

TY  - JOUR
AU  - Милановић Маштраповић, Весна Д.
AU  - Савић, Слађана Д.
AU  - Софренић, Ивана В.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6567
AB  - У октобру 2023. године обележено је 170 година од када је на Лицеју одржано прво предавање из хемије, и тиме исписане прве странице историје модерне хемије у Србији. Како бисмо боље разумели садашњи тренутак и сагледали развијеност хемије као науке на Универзитету у Београду – Хемијском факултету, вратимо се у време и околности у којима су постављени темељи хемије у Србији. У другом делу чланка дат је опис данашњег стања на Универзитету у Београду – Хемијском факултету.
AB  - In October 2023, we marked 170 years since the first chemistry lecture was held at the Lyceum, when the first pages of the history of modern chemistry in Serbia was written. In order to better understand the present moment and percieve the development of chemistry as a science at
the University of Belgrade – Faculty of Chemistry, we went back to the time and circumstances in which the foundations of chemistry in Serbia were posted. In the second part of the article, description of today’s state at the University of Belgrade – Faculty of Chemistry was provided.
PB  - Београд : Српско хемијско друштво
T2  - Хемијски преглед
T1  - Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду
T1  - A short story about 170 years of chemistry in Serbia and University of Belgrade – Faculty of chemistry
IS  - 65
IS  - 2
SP  - 41
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6567
ER  - 
@article{
author = "Милановић Маштраповић, Весна Д. and Савић, Слађана Д. and Софренић, Ивана В.",
year = "2024",
abstract = "У октобру 2023. године обележено је 170 година од када је на Лицеју одржано прво предавање из хемије, и тиме исписане прве странице историје модерне хемије у Србији. Како бисмо боље разумели садашњи тренутак и сагледали развијеност хемије као науке на Универзитету у Београду – Хемијском факултету, вратимо се у време и околности у којима су постављени темељи хемије у Србији. У другом делу чланка дат је опис данашњег стања на Универзитету у Београду – Хемијском факултету., In October 2023, we marked 170 years since the first chemistry lecture was held at the Lyceum, when the first pages of the history of modern chemistry in Serbia was written. In order to better understand the present moment and percieve the development of chemistry as a science at
the University of Belgrade – Faculty of Chemistry, we went back to the time and circumstances in which the foundations of chemistry in Serbia were posted. In the second part of the article, description of today’s state at the University of Belgrade – Faculty of Chemistry was provided.",
publisher = "Београд : Српско хемијско друштво",
journal = "Хемијски преглед",
title = "Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду, A short story about 170 years of chemistry in Serbia and University of Belgrade – Faculty of chemistry",
number = "65, 2",
pages = "41-44",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6567"
}
Милановић Маштраповић, В. Д., Савић, С. Д.,& Софренић, И. В.. (2024). Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду. in Хемијски преглед
Београд : Српско хемијско друштво.(65), 41-44.
https://hdl.handle.net/21.15107/rcub_cherry_6567
Милановић Маштраповић ВД, Савић СД, Софренић ИВ. Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду. in Хемијски преглед. 2024;(65):41-44.
https://hdl.handle.net/21.15107/rcub_cherry_6567 .
Милановић Маштраповић, Весна Д., Савић, Слађана Д., Софренић, Ивана В., "Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду" in Хемијски преглед, no. 65 (2024):41-44,
https://hdl.handle.net/21.15107/rcub_cherry_6567 .

Supplementary material for the article: T. Jednak Berić, M. M. Vrvić, M. Lješević, J. Avdalović, M. Ilić, D. Crnković, B. Jovančićević, S. Miletić; Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. Environmental Chemistry 21 (2024) EN23111. https://doi.org/10.1071/EN23111

Jednak Berić, Tanja; Vrvić, Miroslav; Lješević, Marija; Avdalović, Jelena; Ilić, Mila; Crnković, Dragan; Jovančićević, Branimir; Miletić, Srđan

(CSIRO Publishing, 2024)

TY  - JOUR
AU  - Jednak Berić, Tanja
AU  - Vrvić, Miroslav
AU  - Lješević, Marija
AU  - Avdalović, Jelena
AU  - Ilić, Mila
AU  - Crnković, Dragan
AU  - Jovančićević, Branimir
AU  - Miletić, Srđan
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6604
AB  - Environmental contextMitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents.RationaleBioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies.MethodologyIn this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction.ResultsIn our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased.DiscussionThe sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.
PB  - CSIRO Publishing
T2  - Environmental Chemistry
T1  - Supplementary material for the article: T. Jednak Berić, M. M. Vrvić, M. Lješević, J. Avdalović, M. Ilić, D. Crnković, B. Jovančićević, S. Miletić; Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. Environmental Chemistry 21 (2024) EN23111. https://doi.org/10.1071/EN23111
VL  - 21
IS  - 5
SP  - EN23111
DO  - 10.1071/EN23111
ER  - 
@article{
author = "Jednak Berić, Tanja and Vrvić, Miroslav and Lješević, Marija and Avdalović, Jelena and Ilić, Mila and Crnković, Dragan and Jovančićević, Branimir and Miletić, Srđan",
year = "2024",
abstract = "Environmental contextMitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents.RationaleBioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies.MethodologyIn this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction.ResultsIn our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased.DiscussionThe sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.",
publisher = "CSIRO Publishing",
journal = "Environmental Chemistry",
title = "Supplementary material for the article: T. Jednak Berić, M. M. Vrvić, M. Lješević, J. Avdalović, M. Ilić, D. Crnković, B. Jovančićević, S. Miletić; Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. Environmental Chemistry 21 (2024) EN23111. https://doi.org/10.1071/EN23111",
volume = "21",
number = "5",
pages = "EN23111",
doi = "10.1071/EN23111"
}
Jednak Berić, T., Vrvić, M., Lješević, M., Avdalović, J., Ilić, M., Crnković, D., Jovančićević, B.,& Miletić, S.. (2024). Supplementary material for the article: T. Jednak Berić, M. M. Vrvić, M. Lješević, J. Avdalović, M. Ilić, D. Crnković, B. Jovančićević, S. Miletić; Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. Environmental Chemistry 21 (2024) EN23111. https://doi.org/10.1071/EN23111. in Environmental Chemistry
CSIRO Publishing., 21(5), EN23111.
https://doi.org/10.1071/EN23111
Jednak Berić T, Vrvić M, Lješević M, Avdalović J, Ilić M, Crnković D, Jovančićević B, Miletić S. Supplementary material for the article: T. Jednak Berić, M. M. Vrvić, M. Lješević, J. Avdalović, M. Ilić, D. Crnković, B. Jovančićević, S. Miletić; Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. Environmental Chemistry 21 (2024) EN23111. https://doi.org/10.1071/EN23111. in Environmental Chemistry. 2024;21(5):EN23111.
doi:10.1071/EN23111 .
Jednak Berić, Tanja, Vrvić, Miroslav, Lješević, Marija, Avdalović, Jelena, Ilić, Mila, Crnković, Dragan, Jovančićević, Branimir, Miletić, Srđan, "Supplementary material for the article: T. Jednak Berić, M. M. Vrvić, M. Lješević, J. Avdalović, M. Ilić, D. Crnković, B. Jovančićević, S. Miletić; Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. Environmental Chemistry 21 (2024) EN23111. https://doi.org/10.1071/EN23111" in Environmental Chemistry, 21, no. 5 (2024):EN23111,
https://doi.org/10.1071/EN23111 . .

NADES-Based Extracts of Selected Medicinal Herbs as Promising Formulations for Cosmetic Usage

Ivković, Đurđa; Cvijetić, Ilija; Radoičić, Aleksandra; Stojković-Filipović, Jelena; Trifković, Jelena; Krstić Ristivojević, Maja; Ristivojević, Petar

(2024)

TY  - JOUR
AU  - Ivković, Đurđa
AU  - Cvijetić, Ilija
AU  - Radoičić, Aleksandra
AU  - Stojković-Filipović, Jelena
AU  - Trifković, Jelena
AU  - Krstić Ristivojević, Maja
AU  - Ristivojević, Petar
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6561
AB  - As a functional extraction medium, natural deep eutectic solvents (NADESs) can dissolve various plant metabolites. Those solvents provide untapped potential for creating novel green extracts with distinctive phytochemical signatures and unique biological activities. This is particularly relevant given the rising need for eco-friendly and sustainable skin care products. The main aim of this work was to optimize the most efficient natural deep eutectic solvents (NADESs) for extracting bioactives from 18 medicinal herbs applicable to the cosmetic industry. Selection of the most potent herbs involved assessing their conventional extracts for tyrosinase inhibition, antioxidant activity, and keratinocyte cytotoxicity. Moreover, we analyzed the phenolic profile using ultra-high-pressure liquid chromatography/mass spectrometry (UHPLC/MS) and spectrophotometric assays such as total phenolic (TPC) and flavonoid content (TFC). Using the COSMO-RS method, we modeled the solubility of 12 phenolics in 64 virtual NADESs and selected the 7 most promising ones for further experimental validation. NADESs, including betaine-urea, betaine-proline, and betaine-lysine, were computationally chosen and demonstrated the highest levels of TPC and antioxidative capacity, as confirmed by in vitro assays. The proposed combination of NADES herbal extracts represents a promising natural constituent for the cosmetic industry.
T2  - Processes
T1  - NADES-Based Extracts of Selected Medicinal Herbs as Promising Formulations for Cosmetic Usage
VL  - 12
IS  - 5
SP  - 992
DO  - 10.3390/pr12050992
ER  - 
@article{
author = "Ivković, Đurđa and Cvijetić, Ilija and Radoičić, Aleksandra and Stojković-Filipović, Jelena and Trifković, Jelena and Krstić Ristivojević, Maja and Ristivojević, Petar",
year = "2024",
abstract = "As a functional extraction medium, natural deep eutectic solvents (NADESs) can dissolve various plant metabolites. Those solvents provide untapped potential for creating novel green extracts with distinctive phytochemical signatures and unique biological activities. This is particularly relevant given the rising need for eco-friendly and sustainable skin care products. The main aim of this work was to optimize the most efficient natural deep eutectic solvents (NADESs) for extracting bioactives from 18 medicinal herbs applicable to the cosmetic industry. Selection of the most potent herbs involved assessing their conventional extracts for tyrosinase inhibition, antioxidant activity, and keratinocyte cytotoxicity. Moreover, we analyzed the phenolic profile using ultra-high-pressure liquid chromatography/mass spectrometry (UHPLC/MS) and spectrophotometric assays such as total phenolic (TPC) and flavonoid content (TFC). Using the COSMO-RS method, we modeled the solubility of 12 phenolics in 64 virtual NADESs and selected the 7 most promising ones for further experimental validation. NADESs, including betaine-urea, betaine-proline, and betaine-lysine, were computationally chosen and demonstrated the highest levels of TPC and antioxidative capacity, as confirmed by in vitro assays. The proposed combination of NADES herbal extracts represents a promising natural constituent for the cosmetic industry.",
journal = "Processes",
title = "NADES-Based Extracts of Selected Medicinal Herbs as Promising Formulations for Cosmetic Usage",
volume = "12",
number = "5",
pages = "992",
doi = "10.3390/pr12050992"
}
Ivković, Đ., Cvijetić, I., Radoičić, A., Stojković-Filipović, J., Trifković, J., Krstić Ristivojević, M.,& Ristivojević, P.. (2024). NADES-Based Extracts of Selected Medicinal Herbs as Promising Formulations for Cosmetic Usage. in Processes, 12(5), 992.
https://doi.org/10.3390/pr12050992
Ivković Đ, Cvijetić I, Radoičić A, Stojković-Filipović J, Trifković J, Krstić Ristivojević M, Ristivojević P. NADES-Based Extracts of Selected Medicinal Herbs as Promising Formulations for Cosmetic Usage. in Processes. 2024;12(5):992.
doi:10.3390/pr12050992 .
Ivković, Đurđa, Cvijetić, Ilija, Radoičić, Aleksandra, Stojković-Filipović, Jelena, Trifković, Jelena, Krstić Ristivojević, Maja, Ristivojević, Petar, "NADES-Based Extracts of Selected Medicinal Herbs as Promising Formulations for Cosmetic Usage" in Processes, 12, no. 5 (2024):992,
https://doi.org/10.3390/pr12050992 . .
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