TY  - JOUR
AU  - Ćurčić, Vladimir
AU  - Olszewski, Mateusz
AU  - Maciejewska, Natalia
AU  - Višnjevac, Aleksandar
AU  - Srdić-Rajić, Tatjana
AU  - Dobričić, Vladimir
AU  - García-Sosa, Alfonso T.
AU  - Kokanov, Sanja B.
AU  - Araškov, Jovana B.
AU  - Silvestri, Romano
AU  - Schüle, Roland
AU  - Jung, Manfred
AU  - Nikolić, Milan
AU  - Filipović, Nenad R.
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6392
AB  - Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.
PB  - John Wiley and Sons Inc
T2  - Archiv der Pharmazie
T2  - Archiv der Pharmazie
T1  - Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
VL  - n/a
IS  - n/a
SP  - e2300426
DO  - 10.1002/ardp.202300426
ER  - 

@article{
author = "Ćurčić, Vladimir and Olszewski, Mateusz and Maciejewska, Natalia and Višnjevac, Aleksandar and Srdić-Rajić, Tatjana and Dobričić, Vladimir and García-Sosa, Alfonso T. and Kokanov, Sanja B. and Araškov, Jovana B. and Silvestri, Romano and Schüle, Roland and Jung, Manfred and Nikolić, Milan and Filipović, Nenad R.",
abstract = "Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.",
publisher = "John Wiley and Sons Inc",
journal = "Archiv der Pharmazie, Archiv der Pharmazie",
title = "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition",
volume = "n/a",
number = "n/a",
pages = "e2300426",
doi = "10.1002/ardp.202300426"
}

Ćurčić, V., Olszewski, M., Maciejewska, N., Višnjevac, A., Srdić-Rajić, T., Dobričić, V., García-Sosa, A. T., Kokanov, S. B., Araškov, J. B., Silvestri, R., Schüle, R., Jung, M., Nikolić, M.,& Filipović, N. R..Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie
John Wiley and Sons Inc., n/a(n/a), e2300426.
https://doi.org/10.1002/ardp.202300426

Ćurčić V, Olszewski M, Maciejewska N, Višnjevac A, Srdić-Rajić T, Dobričić V, García-Sosa AT, Kokanov SB, Araškov JB, Silvestri R, Schüle R, Jung M, Nikolić M, Filipović NR. Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie.n/a(n/a):e2300426.
doi:10.1002/ardp.202300426 .

Ćurčić, Vladimir, Olszewski, Mateusz, Maciejewska, Natalia, Višnjevac, Aleksandar, Srdić-Rajić, Tatjana, Dobričić, Vladimir, García-Sosa, Alfonso T., Kokanov, Sanja B., Araškov, Jovana B., Silvestri, Romano, Schüle, Roland, Jung, Manfred, Nikolić, Milan, Filipović, Nenad R., "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition" in Archiv der Pharmazie, n/a, no. n/a:e2300426,
https://doi.org/10.1002/ardp.202300426 . .

TY  - JOUR
AU  - Pastor, Ferenc T.
AU  - Dojčinović, Biljana P.
AU  - Kodranov, Igor D.
AU  - Gorjanović, Stanislava Ž.
AU  - Ivanović, Tijana
AU  - Popović, Daniela Ž.
AU  - Miladinović, Jelena
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6390
AB  - Due to the similar chemical properties of Ni2+ and Co2+, several dozens of adsorptive stripping voltammetric (AdSV) methods have been developed for their simultaneous determination. The question was would there be some benefits if a stripping method made for simultaneous determination of Ni2+ and Co2+ will be optimized for the determination of only one of them (Ni2+). It was found that the optimized method has for an order of magnitude lower LOQ (1.89×10−10 M), an order of magnitude lower influence of Co2+, and the applicability of one calibration line for four orders of magnitude of Ni2+ concentration. The influence of some common anions and cations has been examined. The developed method was successfully applied for nickel content determination in real samples. The suitability of the developed method for the determination of Co2+ from the same solution in the second run, upon optimizations of deposition potential and time, was also explored. The LOQ obtained for Co2+ (3.61×10−11 M) is almost two orders of magnitude lower than LOQ of the method for simultaneous determination of both cations and, its LOD and LOQ are among few lowest obtained by AdSV methods for Co2+ determination. The developed method for Ni2+ and Co2+ determination from the same solution in two successive runs has significantly better analytical performances than the starting method for their simultaneous determination in one run.
PB  - Wiley
T2  - Electroanalysis
T1  - 2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination
VL  - n/a
IS  - n/a
SP  - e202300259
DO  - 10.1002/elan.202300259
ER  - 

@article{
author = "Pastor, Ferenc T. and Dojčinović, Biljana P. and Kodranov, Igor D. and Gorjanović, Stanislava Ž. and Ivanović, Tijana and Popović, Daniela Ž. and Miladinović, Jelena",
abstract = "Due to the similar chemical properties of Ni2+ and Co2+, several dozens of adsorptive stripping voltammetric (AdSV) methods have been developed for their simultaneous determination. The question was would there be some benefits if a stripping method made for simultaneous determination of Ni2+ and Co2+ will be optimized for the determination of only one of them (Ni2+). It was found that the optimized method has for an order of magnitude lower LOQ (1.89×10−10 M), an order of magnitude lower influence of Co2+, and the applicability of one calibration line for four orders of magnitude of Ni2+ concentration. The influence of some common anions and cations has been examined. The developed method was successfully applied for nickel content determination in real samples. The suitability of the developed method for the determination of Co2+ from the same solution in the second run, upon optimizations of deposition potential and time, was also explored. The LOQ obtained for Co2+ (3.61×10−11 M) is almost two orders of magnitude lower than LOQ of the method for simultaneous determination of both cations and, its LOD and LOQ are among few lowest obtained by AdSV methods for Co2+ determination. The developed method for Ni2+ and Co2+ determination from the same solution in two successive runs has significantly better analytical performances than the starting method for their simultaneous determination in one run.",
publisher = "Wiley",
journal = "Electroanalysis",
title = "2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination",
volume = "n/a",
number = "n/a",
pages = "e202300259",
doi = "10.1002/elan.202300259"
}

Pastor, F. T., Dojčinović, B. P., Kodranov, I. D., Gorjanović, S. Ž., Ivanović, T., Popović, D. Ž.,& Miladinović, J..2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination. in Electroanalysis
Wiley., n/a(n/a), e202300259.
https://doi.org/10.1002/elan.202300259

Pastor FT, Dojčinović BP, Kodranov ID, Gorjanović SŽ, Ivanović T, Popović DŽ, Miladinović J. 2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination. in Electroanalysis.n/a(n/a):e202300259.
doi:10.1002/elan.202300259 .

Pastor, Ferenc T., Dojčinović, Biljana P., Kodranov, Igor D., Gorjanović, Stanislava Ž., Ivanović, Tijana, Popović, Daniela Ž., Miladinović, Jelena, "2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination" in Electroanalysis, n/a, no. n/a:e202300259,
https://doi.org/10.1002/elan.202300259 . .

TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana 
AU  - Kostić-Rajačić, Slađana
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 

@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana  and Kostić-Rajačić, Slađana",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}

Penjišević, J., Šukalović, V., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D.,& Kostić-Rajačić, S..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845

Penjišević J, Šukalović V, Dukić-Stefanović S, Deuther-Conrad W, Andrić D, Kostić-Rajačić S. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

Penjišević, Jelena , Šukalović, Vladimir , Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana , Kostić-Rajačić, Slađana, "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

TY  - DATA
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Bošković, Jakša
AU  - Baranac-Stojanović, Marija
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5846
AB  - We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.
PB  - Royal Society of Chemistry
T2  - Organic & Biomolecular Chemistry
T1  - Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F
VL  - 21
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5846
ER  - 

@misc{
author = "Aleksić, Jovana and Stojanović, Milovan and Bošković, Jakša and Baranac-Stojanović, Marija",
abstract = "We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.",
publisher = "Royal Society of Chemistry",
journal = "Organic & Biomolecular Chemistry",
title = "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F",
volume = "21",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5846"
}

Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M..Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846

Aleksić J, Stojanović M, Bošković J, Baranac-Stojanović M. Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry.21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

Aleksić, Jovana, Stojanović, Milovan, Bošković, Jakša, Baranac-Stojanović, Marija, "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F" in Organic & Biomolecular Chemistry, 21, no. 6,
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

TY  - JOUR
AU  - Đurašinović, Tatjana
AU  - Lopandić, Zorana
AU  - Protić-Rosić, Isidora
AU  - Nešić, Andrijana
AU  - Trbojević-Ivić, Jovana
AU  - Jappe, Uta
AU  - Gavrović-Jankulović, Marija
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6338
AB  - Banana allergy is often associated with the pollen and latex allergies, which led us to the  hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-L-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons,
while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting ≥ 90 % sequence homology with relevant plant SAHH allergens. Our findings have elucidated SAHH as a novel plant panallergen, underlying the cross-reactivity between plant derived food and respiratory allergens, confirming our initial hypothesis.
PB  - Elsevier
T2  - Food Chemistry
T1  - Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen
VL  - 437
SP  - 137782
DO  - 10.1016/j.foodchem.2023.137782
ER  - 

@article{
author = "Đurašinović, Tatjana and Lopandić, Zorana and Protić-Rosić, Isidora and Nešić, Andrijana and Trbojević-Ivić, Jovana and Jappe, Uta and Gavrović-Jankulović, Marija",
year = "2024",
abstract = "Banana allergy is often associated with the pollen and latex allergies, which led us to the  hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-L-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons,
while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting ≥ 90 % sequence homology with relevant plant SAHH allergens. Our findings have elucidated SAHH as a novel plant panallergen, underlying the cross-reactivity between plant derived food and respiratory allergens, confirming our initial hypothesis.",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen",
volume = "437",
pages = "137782",
doi = "10.1016/j.foodchem.2023.137782"
}

Đurašinović, T., Lopandić, Z., Protić-Rosić, I., Nešić, A., Trbojević-Ivić, J., Jappe, U.,& Gavrović-Jankulović, M.. (2024). Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen. in Food Chemistry
Elsevier., 437, 137782.
https://doi.org/10.1016/j.foodchem.2023.137782

Đurašinović T, Lopandić Z, Protić-Rosić I, Nešić A, Trbojević-Ivić J, Jappe U, Gavrović-Jankulović M. Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen. in Food Chemistry. 2024;437:137782.
doi:10.1016/j.foodchem.2023.137782 .

Đurašinović, Tatjana, Lopandić, Zorana, Protić-Rosić, Isidora, Nešić, Andrijana, Trbojević-Ivić, Jovana, Jappe, Uta, Gavrović-Jankulović, Marija, "Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen" in Food Chemistry, 437 (2024):137782,
https://doi.org/10.1016/j.foodchem.2023.137782 . .

TY  - JOUR
AU  - Milenković, Mila
AU  - Ciasca, Gabriele
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Marković, Olivera
AU  - Verbić, Tatjana
AU  - Todorović Marković, Biljana
AU  - Jovanović, Svetlana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6303
AB  - The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give 
in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, 
smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the 
antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. 
Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic 
resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of 
modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in 
the aromatic, sp2 domains. Namely, γ-irradiation caused a bonding of S atoms in 1.14 at.% mainly as thiol 
groups, and N in 1.81 at.% as amino groups, but sp2 contribution in GQD structure was lowered from 63.00 to 
4.86 at.%, as measured in dots irradiated at a dose of 200 kGy. Fluorescence quenching measurements showed 
that L-cysteine-modified dots are able to bind to human serum albumin. The antibacterial activity of GQDs 
combined with 1 and 6 h of blue light (470 nm) irradiation was tested against 8 bacterial strains. GQD-cys-25 
sample provided the best results, with minimum inhibitory concentration (MIC) as low as 125 μg/mL against 
S. aureus, E. faecalis, and E. coli after only 1 h of blue light exposure.
PB  - Elsevier
T2  - Journal of Photochemistry & Photobiology, B: Biology
T1  - Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects
VL  - 250
SP  - 112818
DO  - 10.1016/j.jphotobiol.2023.112818
ER  - 

@article{
author = "Milenković, Mila and Ciasca, Gabriele and Bonasera, Aurelio and Scopelliti, Michelangelo and Marković, Olivera and Verbić, Tatjana and Todorović Marković, Biljana and Jovanović, Svetlana",
year = "2024",
abstract = "The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give 
in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, 
smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the 
antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. 
Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic 
resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of 
modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in 
the aromatic, sp2 domains. Namely, γ-irradiation caused a bonding of S atoms in 1.14 at.% mainly as thiol 
groups, and N in 1.81 at.% as amino groups, but sp2 contribution in GQD structure was lowered from 63.00 to 
4.86 at.%, as measured in dots irradiated at a dose of 200 kGy. Fluorescence quenching measurements showed 
that L-cysteine-modified dots are able to bind to human serum albumin. The antibacterial activity of GQDs 
combined with 1 and 6 h of blue light (470 nm) irradiation was tested against 8 bacterial strains. GQD-cys-25 
sample provided the best results, with minimum inhibitory concentration (MIC) as low as 125 μg/mL against 
S. aureus, E. faecalis, and E. coli after only 1 h of blue light exposure.",
publisher = "Elsevier",
journal = "Journal of Photochemistry & Photobiology, B: Biology",
title = "Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects",
volume = "250",
pages = "112818",
doi = "10.1016/j.jphotobiol.2023.112818"
}

Milenković, M., Ciasca, G., Bonasera, A., Scopelliti, M., Marković, O., Verbić, T., Todorović Marković, B.,& Jovanović, S.. (2024). Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects. in Journal of Photochemistry & Photobiology, B: Biology
Elsevier., 250, 112818.
https://doi.org/10.1016/j.jphotobiol.2023.112818

Milenković M, Ciasca G, Bonasera A, Scopelliti M, Marković O, Verbić T, Todorović Marković B, Jovanović S. Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects. in Journal of Photochemistry & Photobiology, B: Biology. 2024;250:112818.
doi:10.1016/j.jphotobiol.2023.112818 .

Milenković, Mila, Ciasca, Gabriele, Bonasera, Aurelio, Scopelliti, Michelangelo, Marković, Olivera, Verbić, Tatjana, Todorović Marković, Biljana, Jovanović, Svetlana, "Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects" in Journal of Photochemistry & Photobiology, B: Biology, 250 (2024):112818,
https://doi.org/10.1016/j.jphotobiol.2023.112818 . .

TY  - JOUR
AU  - Rašković, Aleksandar
AU  - Martić, Nikola
AU  - Tomas, Ana
AU  - Andrejić-Višnjić, Bojana
AU  - Bosanac, Milana
AU  - Atanasković, Marko
AU  - Nemet, Marko
AU  - Popović, Radmila
AU  - Krstić, Marko
AU  - Vukmirović, Saša
AU  - Stilinović, Nebojša
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6396
AB  - Dyslipidemia and obesity are recognized as two of the major global health issues and main risk factors for coronary heart disease and cerebrovascular disease. In recent years, carob has shown certain antioxidant and anti-dyslipidemic potential. In this study, Wistar rats were fed with a standard and cholesterol-enriched diet and treated orally with carob extract and simvastatin for four weeks. After sacrifice, blood samples were collected for biochemical analysis, and liver tissue was taken for histological and immunohistochemical assessment. Weight gain was significantly higher in groups fed with cholesterol-fortified granules; total cholesterol was found to be significantly lower in the hypercholesterolemic groups treated with simvastatin and simvastatin/carob combined regimens compared with hypercholesterolemic animals treated with saline (p < 0.05). The same was true for low-density lipoprotein cholesterol and the LDL/HDL ratio (p < 0.05). Adiponectin was remarkably higher in animals treated with simvastatin compared to all other groups (p < 0.05). Leptin was significantly lower in groups treated with carob and simvastatin compared to the hypercholesterolemic group treated with saline (p < 0.05). Carob/simvastatin co-administration reduced hepatocyte damage and improved liver morphology. A study confirmed the anti-dyslipidemic, anti-obesity, and hepatoprotective potential of carob pulp alone or in combination with simvastatin in the treatment of high-fat diet-fed rats.
PB  - MDPI
T2  - Pharmaceutics
T1  - Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model
VL  - 15
IS  - 11
SP  - 2611
DO  - 10.3390/pharmaceutics15112611
ER  - 

@article{
author = "Rašković, Aleksandar and Martić, Nikola and Tomas, Ana and Andrejić-Višnjić, Bojana and Bosanac, Milana and Atanasković, Marko and Nemet, Marko and Popović, Radmila and Krstić, Marko and Vukmirović, Saša and Stilinović, Nebojša",
year = "2023",
abstract = "Dyslipidemia and obesity are recognized as two of the major global health issues and main risk factors for coronary heart disease and cerebrovascular disease. In recent years, carob has shown certain antioxidant and anti-dyslipidemic potential. In this study, Wistar rats were fed with a standard and cholesterol-enriched diet and treated orally with carob extract and simvastatin for four weeks. After sacrifice, blood samples were collected for biochemical analysis, and liver tissue was taken for histological and immunohistochemical assessment. Weight gain was significantly higher in groups fed with cholesterol-fortified granules; total cholesterol was found to be significantly lower in the hypercholesterolemic groups treated with simvastatin and simvastatin/carob combined regimens compared with hypercholesterolemic animals treated with saline (p < 0.05). The same was true for low-density lipoprotein cholesterol and the LDL/HDL ratio (p < 0.05). Adiponectin was remarkably higher in animals treated with simvastatin compared to all other groups (p < 0.05). Leptin was significantly lower in groups treated with carob and simvastatin compared to the hypercholesterolemic group treated with saline (p < 0.05). Carob/simvastatin co-administration reduced hepatocyte damage and improved liver morphology. A study confirmed the anti-dyslipidemic, anti-obesity, and hepatoprotective potential of carob pulp alone or in combination with simvastatin in the treatment of high-fat diet-fed rats.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model",
volume = "15",
number = "11",
pages = "2611",
doi = "10.3390/pharmaceutics15112611"
}

Rašković, A., Martić, N., Tomas, A., Andrejić-Višnjić, B., Bosanac, M., Atanasković, M., Nemet, M., Popović, R., Krstić, M., Vukmirović, S.,& Stilinović, N.. (2023). Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model. in Pharmaceutics
MDPI., 15(11), 2611.
https://doi.org/10.3390/pharmaceutics15112611

Rašković A, Martić N, Tomas A, Andrejić-Višnjić B, Bosanac M, Atanasković M, Nemet M, Popović R, Krstić M, Vukmirović S, Stilinović N. Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model. in Pharmaceutics. 2023;15(11):2611.
doi:10.3390/pharmaceutics15112611 .

Rašković, Aleksandar, Martić, Nikola, Tomas, Ana, Andrejić-Višnjić, Bojana, Bosanac, Milana, Atanasković, Marko, Nemet, Marko, Popović, Radmila, Krstić, Marko, Vukmirović, Saša, Stilinović, Nebojša, "Carob Extract (Ceratonia siliqua L.): Effects on Dyslipidemia and Obesity in a High-Fat Diet-Fed Rat Model" in Pharmaceutics, 15, no. 11 (2023):2611,
https://doi.org/10.3390/pharmaceutics15112611 . .

TY  - THES
AU  - Protić, Sara
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5871
AB  - Pandemija izazvana virusom SARS-CoV-2 se pojavila krajem decembra 2019. godine u Vuhanu
u Kini, kada su prvi put zapažena teška respiratorna oboljenja. Od tada se virus brzo proširio u
Kini, ali i u drugim državama i izazvao veliku globalnu zabrinutost. U Srbiji je polovinom marta
2020. nakon registrovanja prvih slučajeva obolelih i proglašenja pandemije od strane Svetske
zdravstvene organizacije uvedeno vanredno stanje. Novi virus SARS-CoV-2 je dobio ime zbog
svoje strukturne sličnosti sa korona virusima koji izazivaju teške respiratorne simptome.
T1  - Kloniranje proteaze slične papainu PL pro SARS-CoV-2 u E.coli, heterologna ekspresija, prečišćavanje i razvoj inhibitornog enzimskog eseja za pretragu potencijalnih lekova
SP  - 2
EP  - 35
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5871
ER  - 

@misc{
author = "Protić, Sara",
year = "2023",
abstract = "Pandemija izazvana virusom SARS-CoV-2 se pojavila krajem decembra 2019. godine u Vuhanu
u Kini, kada su prvi put zapažena teška respiratorna oboljenja. Od tada se virus brzo proširio u
Kini, ali i u drugim državama i izazvao veliku globalnu zabrinutost. U Srbiji je polovinom marta
2020. nakon registrovanja prvih slučajeva obolelih i proglašenja pandemije od strane Svetske
zdravstvene organizacije uvedeno vanredno stanje. Novi virus SARS-CoV-2 je dobio ime zbog
svoje strukturne sličnosti sa korona virusima koji izazivaju teške respiratorne simptome.",
title = "Kloniranje proteaze slične papainu PL pro SARS-CoV-2 u E.coli, heterologna ekspresija, prečišćavanje i razvoj inhibitornog enzimskog eseja za pretragu potencijalnih lekova",
pages = "2-35",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5871"
}

Protić, S.. (2023). Kloniranje proteaze slične papainu PL pro SARS-CoV-2 u E.coli, heterologna ekspresija, prečišćavanje i razvoj inhibitornog enzimskog eseja za pretragu potencijalnih lekova. , 2-35.
https://hdl.handle.net/21.15107/rcub_cherry_5871

Protić S. Kloniranje proteaze slične papainu PL pro SARS-CoV-2 u E.coli, heterologna ekspresija, prečišćavanje i razvoj inhibitornog enzimskog eseja za pretragu potencijalnih lekova. 2023;:2-35.
https://hdl.handle.net/21.15107/rcub_cherry_5871 .

Protić, Sara, "Kloniranje proteaze slične papainu PL pro SARS-CoV-2 u E.coli, heterologna ekspresija, prečišćavanje i razvoj inhibitornog enzimskog eseja za pretragu potencijalnih lekova" (2023):2-35,
https://hdl.handle.net/21.15107/rcub_cherry_5871 .

TY  - JOUR
AU  - Glišić, Sanja
AU  - Prodanović, Radivoje
AU  - Paessler, Slobodan
AU  - Perović, Vladimir
AU  - Milićević, Jelena
AU  - Prodanović, Olivera
AU  - Senčanski, Milan 
AU  - Kaličanin, Nevena
AU  - Protić, Sara
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5884
AB  - Finding an effective drug to prevent or treat COVID-19 is of utmost importance in tcurrent pandemic. Since developing a new treatment takes a significant amount of time, drug repurposing can be an effective option for achieving a rapid response. This study used a combined in silico virtual screening protocol for candidate SARS-CoV-2 PLpro inhibitors. The Drugbank database was searched first, using the Informational Spectrum Method for Small Molecules, followed by molecular docking. Gramicidin D was selected as a peptide drug, showing the best in silico interaction profile with PLpro. After the expression and purification of PLpro, gramicidin D was screened for protease inhibition in vitro and was found to be active against PLpro. The current study’s findings are significant because it is critical to identify COVID-19 therapies that are efficient, affordable, and have a favorable safety profile.
PB  - MDPI
T2  - Int. J. Mol. Sci.
T1  - In Silico and In Vitro Inhibition of SARS-CoV-2 PLpro with Gramicidin D
VL  - 24
IS  - 3
SP  - 1955
DO  - 10.3390/ijms24031955
ER  - 

@article{
author = "Glišić, Sanja and Prodanović, Radivoje and Paessler, Slobodan and Perović, Vladimir and Milićević, Jelena and Prodanović, Olivera and Senčanski, Milan  and Kaličanin, Nevena and Protić, Sara",
year = "2023",
abstract = "Finding an effective drug to prevent or treat COVID-19 is of utmost importance in tcurrent pandemic. Since developing a new treatment takes a significant amount of time, drug repurposing can be an effective option for achieving a rapid response. This study used a combined in silico virtual screening protocol for candidate SARS-CoV-2 PLpro inhibitors. The Drugbank database was searched first, using the Informational Spectrum Method for Small Molecules, followed by molecular docking. Gramicidin D was selected as a peptide drug, showing the best in silico interaction profile with PLpro. After the expression and purification of PLpro, gramicidin D was screened for protease inhibition in vitro and was found to be active against PLpro. The current study’s findings are significant because it is critical to identify COVID-19 therapies that are efficient, affordable, and have a favorable safety profile.",
publisher = "MDPI",
journal = "Int. J. Mol. Sci.",
title = "In Silico and In Vitro Inhibition of SARS-CoV-2 PLpro with Gramicidin D",
volume = "24",
number = "3",
pages = "1955",
doi = "10.3390/ijms24031955"
}

Glišić, S., Prodanović, R., Paessler, S., Perović, V., Milićević, J., Prodanović, O., Senčanski, M., Kaličanin, N.,& Protić, S.. (2023). In Silico and In Vitro Inhibition of SARS-CoV-2 PLpro with Gramicidin D. in Int. J. Mol. Sci.
MDPI., 24(3), 1955.
https://doi.org/10.3390/ijms24031955

Glišić S, Prodanović R, Paessler S, Perović V, Milićević J, Prodanović O, Senčanski M, Kaličanin N, Protić S. In Silico and In Vitro Inhibition of SARS-CoV-2 PLpro with Gramicidin D. in Int. J. Mol. Sci.. 2023;24(3):1955.
doi:10.3390/ijms24031955 .

Glišić, Sanja, Prodanović, Radivoje, Paessler, Slobodan, Perović, Vladimir, Milićević, Jelena, Prodanović, Olivera, Senčanski, Milan , Kaličanin, Nevena, Protić, Sara, "In Silico and In Vitro Inhibition of SARS-CoV-2 PLpro with Gramicidin D" in Int. J. Mol. Sci., 24, no. 3 (2023):1955,
https://doi.org/10.3390/ijms24031955 . .

TY  - THES
AU  - Stošić, Anja
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6116
AB  - Cilj ovog rada je optimizacija sinteze alginata modifikovanog tiraminom i potvrda uspešnosti modifikacije alginata ultraljubičasto-vidljivom i infracrvenom spektroskopijom. Ekspresija lakaze iz Streptomyces cyaneus na površini ćelijskih zidova kvasca Saccharomyces cerevisiae, liziranje ćelija i imobilizacija dobijenih ćelijskih zidova u kalcijum-tiramin-alginatnim kuglicama. Dodatno umrežavanje dobijenih biokatalizatora fotopolimerizacijom vidljivom svetlošću, u prisustvo fotoinicijatora riboflavina, a u cilju dobijanja biokatalizatora sa poboljšanim karakteristikama i sposobnošću višekratne upotrebe. Određivanje temperaturne i pH stabilnosti fotopolimerizovanog i nefotopolimerizovanog imobilizovanog biokatalizatora, njegove efikasnosti u dekolorizaciji sintetičkih boja.
T1  - Fotopolimerizacija vidljivom svetlošću tiraminom modifikovanog alginata za imobilizaciju ćelijskih zidova S. cerevisiae sa heterologno eksprimiranom lakazom iz Streptomyces cyaneus
SP  - 2
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6116
ER  - 

@misc{
author = "Stošić, Anja",
year = "2023",
abstract = "Cilj ovog rada je optimizacija sinteze alginata modifikovanog tiraminom i potvrda uspešnosti modifikacije alginata ultraljubičasto-vidljivom i infracrvenom spektroskopijom. Ekspresija lakaze iz Streptomyces cyaneus na površini ćelijskih zidova kvasca Saccharomyces cerevisiae, liziranje ćelija i imobilizacija dobijenih ćelijskih zidova u kalcijum-tiramin-alginatnim kuglicama. Dodatno umrežavanje dobijenih biokatalizatora fotopolimerizacijom vidljivom svetlošću, u prisustvo fotoinicijatora riboflavina, a u cilju dobijanja biokatalizatora sa poboljšanim karakteristikama i sposobnošću višekratne upotrebe. Određivanje temperaturne i pH stabilnosti fotopolimerizovanog i nefotopolimerizovanog imobilizovanog biokatalizatora, njegove efikasnosti u dekolorizaciji sintetičkih boja.",
title = "Fotopolimerizacija vidljivom svetlošću tiraminom modifikovanog alginata za imobilizaciju ćelijskih zidova S. cerevisiae sa heterologno eksprimiranom lakazom iz Streptomyces cyaneus",
pages = "2-42",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6116"
}

Stošić, A.. (2023). Fotopolimerizacija vidljivom svetlošću tiraminom modifikovanog alginata za imobilizaciju ćelijskih zidova S. cerevisiae sa heterologno eksprimiranom lakazom iz Streptomyces cyaneus. , 2-42.
https://hdl.handle.net/21.15107/rcub_cherry_6116

Stošić A. Fotopolimerizacija vidljivom svetlošću tiraminom modifikovanog alginata za imobilizaciju ćelijskih zidova S. cerevisiae sa heterologno eksprimiranom lakazom iz Streptomyces cyaneus. 2023;:2-42.
https://hdl.handle.net/21.15107/rcub_cherry_6116 .

Stošić, Anja, "Fotopolimerizacija vidljivom svetlošću tiraminom modifikovanog alginata za imobilizaciju ćelijskih zidova S. cerevisiae sa heterologno eksprimiranom lakazom iz Streptomyces cyaneus" (2023):2-42,
https://hdl.handle.net/21.15107/rcub_cherry_6116 .

TY  - THES
AU  - Budimirović, Ana
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6158
AB  - Glukoza-oksidaza (E.C. 1.1.3.4) (GOx) je oksidoreduktaza, flavoprotein koji katalizuje oksidaciju β-D-glukoze u glukonsku kiselinu koristeći molekulski kiseonik kao akceptor elektrona uz istovremenu proizvodnju vodonik-peroksida. Ona je važan industrijski enzim koji se koristi kao biokatalizator u industriji hrane za proizvodnju glukonske kiseline, uklanjanje kiseonika i sterilizaciju. U farmaceutskoj industriji se koristi kao biosenzor za određivanje koncentracije glukoze. Izbeljivanje glukoza oksidazom u tekstilnoj industriji predstavlja veći ekonomski i ekološki potencijal u poređenju sa klasičnim postupkom sa dodatkom vodonik-peroksida. Kako bi se povećala primena ovog enzima potrebno je da se unaprede neki od njegovih osobina kao što su aktivnost, pH i temperaturna stabilnost.
Usled toga što nestabilnosti trodimenzionalne strukture GOx-a najviše doprinosi oksidacija metioninskih ostataka, jedna od ideja je da se oni mutiraju kako bi se utvrdilo da li dolazi do povećanja oksidativne stabilnosti enzima. Utvrđeno je da najveći uticaj na povećanje aktivnosti imaju mutacije u blizini aktivnog centra enzima i to uz zadržavanje slične aktivnosti koju poseduje i nemutirani enzim.
Imobilizacijom bi trebalo da se postigne dodatna veća pH i temperaturna stabilnost, mogućnost ponovnog korišćenja uz zadržavanje aktivnosti. Cilj ovog rada je karakterizacija slobodne, biomineralizovane, oksidovane i neoksidovane komercijalne GOx i rekombinante GOx iz Aspergillus niger proizvedene u kvascu P. pastoris (wtGOx), poređenje njihove temperaturne stabilnosti, specifične aktivnosti i uspešnosti oksidacije perjodatom.
T1  - Biomineralizacija rekombinantne glukoza-oksidaze iz gljive Aspergillus niger heterologno eksprimirane u kvascu P. pastoris
SP  - 2
EP  - 40
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6158
ER  - 

@mastersthesis{
author = "Budimirović, Ana",
year = "2023",
abstract = "Glukoza-oksidaza (E.C. 1.1.3.4) (GOx) je oksidoreduktaza, flavoprotein koji katalizuje oksidaciju β-D-glukoze u glukonsku kiselinu koristeći molekulski kiseonik kao akceptor elektrona uz istovremenu proizvodnju vodonik-peroksida. Ona je važan industrijski enzim koji se koristi kao biokatalizator u industriji hrane za proizvodnju glukonske kiseline, uklanjanje kiseonika i sterilizaciju. U farmaceutskoj industriji se koristi kao biosenzor za određivanje koncentracije glukoze. Izbeljivanje glukoza oksidazom u tekstilnoj industriji predstavlja veći ekonomski i ekološki potencijal u poređenju sa klasičnim postupkom sa dodatkom vodonik-peroksida. Kako bi se povećala primena ovog enzima potrebno je da se unaprede neki od njegovih osobina kao što su aktivnost, pH i temperaturna stabilnost.
Usled toga što nestabilnosti trodimenzionalne strukture GOx-a najviše doprinosi oksidacija metioninskih ostataka, jedna od ideja je da se oni mutiraju kako bi se utvrdilo da li dolazi do povećanja oksidativne stabilnosti enzima. Utvrđeno je da najveći uticaj na povećanje aktivnosti imaju mutacije u blizini aktivnog centra enzima i to uz zadržavanje slične aktivnosti koju poseduje i nemutirani enzim.
Imobilizacijom bi trebalo da se postigne dodatna veća pH i temperaturna stabilnost, mogućnost ponovnog korišćenja uz zadržavanje aktivnosti. Cilj ovog rada je karakterizacija slobodne, biomineralizovane, oksidovane i neoksidovane komercijalne GOx i rekombinante GOx iz Aspergillus niger proizvedene u kvascu P. pastoris (wtGOx), poređenje njihove temperaturne stabilnosti, specifične aktivnosti i uspešnosti oksidacije perjodatom.",
title = "Biomineralizacija rekombinantne glukoza-oksidaze iz gljive Aspergillus niger heterologno eksprimirane u kvascu P. pastoris",
pages = "2-40",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6158"
}

Budimirović, A.. (2023). Biomineralizacija rekombinantne glukoza-oksidaze iz gljive Aspergillus niger heterologno eksprimirane u kvascu P. pastoris. , 2-40.
https://hdl.handle.net/21.15107/rcub_cherry_6158

Budimirović A. Biomineralizacija rekombinantne glukoza-oksidaze iz gljive Aspergillus niger heterologno eksprimirane u kvascu P. pastoris. 2023;:2-40.
https://hdl.handle.net/21.15107/rcub_cherry_6158 .

Budimirović, Ana, "Biomineralizacija rekombinantne glukoza-oksidaze iz gljive Aspergillus niger heterologno eksprimirane u kvascu P. pastoris" (2023):2-40,
https://hdl.handle.net/21.15107/rcub_cherry_6158 .

TY  - THES
AU  - Vukotić, Nikola
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6173
AB  - Kako su α-glukozidaze prisutne u brojnim organizmima, u sva tri carstva organizama,
očigledna je bitnost α-glukozidaza. Takođe, kao neinvertujući enzim imaju sposobnost da
pored glikozilacione reakcije katalizuju i transglikozilacionu reakciju, gdje leži potencijal za
upotrebu α-glukozidaza u komercijalne i medicinske svrhe, npr. poboljšanja farmakokinetičkih
osobina nekih lijekova prevođenjem u glikozide. Osim upotrebe α-glukozidaza,
bitno je i razumijevanje kinetike i mehanizma ovih enzima, jer su upravo oni meta dejstva
brojnih inhibitornih lijekova koji se koriste kod npr. dijabetesa tipa 2.
Tehnikama proteinskog inžinjeringa je moguće uvesti mutacije koje će poboljšati osobine α-
glukozidaze. Saturaciona mutageneza jeste jedna od metoda proteinskog inžinjeringa koja
omogućava dizajniranje kolekcije mutanata koje na tačno određenoj poziciji imaju izmjenjen
kodon, odnosno, izmjenjenu aminokiselinu sa bilo kojom od mogućih 19.
T1  - Izolovanje i karakterizacija hidrolitičke i transglikozilacione aktivnosti mutanta α-glukozidaze iz S. cerevisiae eksprimirane u periplazmi E. coli
SP  - 3
EP  - 41
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6173
ER  - 

@mastersthesis{
author = "Vukotić, Nikola",
year = "2023",
abstract = "Kako su α-glukozidaze prisutne u brojnim organizmima, u sva tri carstva organizama,
očigledna je bitnost α-glukozidaza. Takođe, kao neinvertujući enzim imaju sposobnost da
pored glikozilacione reakcije katalizuju i transglikozilacionu reakciju, gdje leži potencijal za
upotrebu α-glukozidaza u komercijalne i medicinske svrhe, npr. poboljšanja farmakokinetičkih
osobina nekih lijekova prevođenjem u glikozide. Osim upotrebe α-glukozidaza,
bitno je i razumijevanje kinetike i mehanizma ovih enzima, jer su upravo oni meta dejstva
brojnih inhibitornih lijekova koji se koriste kod npr. dijabetesa tipa 2.
Tehnikama proteinskog inžinjeringa je moguće uvesti mutacije koje će poboljšati osobine α-
glukozidaze. Saturaciona mutageneza jeste jedna od metoda proteinskog inžinjeringa koja
omogućava dizajniranje kolekcije mutanata koje na tačno određenoj poziciji imaju izmjenjen
kodon, odnosno, izmjenjenu aminokiselinu sa bilo kojom od mogućih 19.",
title = "Izolovanje i karakterizacija hidrolitičke i transglikozilacione aktivnosti mutanta α-glukozidaze iz S. cerevisiae eksprimirane u periplazmi E. coli",
pages = "3-41",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6173"
}

Vukotić, N.. (2023). Izolovanje i karakterizacija hidrolitičke i transglikozilacione aktivnosti mutanta α-glukozidaze iz S. cerevisiae eksprimirane u periplazmi E. coli. , 3-41.
https://hdl.handle.net/21.15107/rcub_cherry_6173

Vukotić N. Izolovanje i karakterizacija hidrolitičke i transglikozilacione aktivnosti mutanta α-glukozidaze iz S. cerevisiae eksprimirane u periplazmi E. coli. 2023;:3-41.
https://hdl.handle.net/21.15107/rcub_cherry_6173 .

Vukotić, Nikola, "Izolovanje i karakterizacija hidrolitičke i transglikozilacione aktivnosti mutanta α-glukozidaze iz S. cerevisiae eksprimirane u periplazmi E. coli" (2023):3-41,
https://hdl.handle.net/21.15107/rcub_cherry_6173 .

TY  - CONF
AU  - Surudžić, Nevena
AU  - Spasojević, Dragica
AU  - Stanković, Mira
AU  - Spasojević, Milica
AU  - Elgahwash, Reyadh Gomah Amar
AU  - Prodanović, Radivoje
AU  - Prodanović, Olivera
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6198
AB  - Natural polymers such as alginate, pectin, chitosan etc. were used as carriers for the immobilization of different types of enzymes. Among investigated enzymes, peroxidases hold a special place. Immobilized enzymes are frequently used in phenol removal reactions. In this research horseradish peroxidase was immobilized within alginate micro-beads. This natural polymer was previously oxidized with sodium periodate and modified with tyramine hydrochloride. Percent of oxidation was varied from 2.5 mol% to 10 mol%, and an increase in specific activity was noticed with increasing the oxidation percent. Immobilized peroxidases showed satisfactory stabilities after 10 days of storage. Phenol concentration in a batch reactor decreased during its oxidation with horseradish peroxidase immobilized on tyramine-alginate hydrogels.
PB  - University of Belgrade, Technical Faculty in Bor
C3  - 30th International Conference Ecological Truth and Environmental Research – EcoTER’23
T1  - Horseradish peroxidase immobilization within micro-beads of oxidized tyramine-alginate for phenol removal from wastewater
SP  - 267
EP  - 271
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2012
ER  - 

@conference{
author = "Surudžić, Nevena and Spasojević, Dragica and Stanković, Mira and Spasojević, Milica and Elgahwash, Reyadh Gomah Amar and Prodanović, Radivoje and Prodanović, Olivera",
year = "2023",
abstract = "Natural polymers such as alginate, pectin, chitosan etc. were used as carriers for the immobilization of different types of enzymes. Among investigated enzymes, peroxidases hold a special place. Immobilized enzymes are frequently used in phenol removal reactions. In this research horseradish peroxidase was immobilized within alginate micro-beads. This natural polymer was previously oxidized with sodium periodate and modified with tyramine hydrochloride. Percent of oxidation was varied from 2.5 mol% to 10 mol%, and an increase in specific activity was noticed with increasing the oxidation percent. Immobilized peroxidases showed satisfactory stabilities after 10 days of storage. Phenol concentration in a batch reactor decreased during its oxidation with horseradish peroxidase immobilized on tyramine-alginate hydrogels.",
publisher = "University of Belgrade, Technical Faculty in Bor",
journal = "30th International Conference Ecological Truth and Environmental Research – EcoTER’23",
title = "Horseradish peroxidase immobilization within micro-beads of oxidized tyramine-alginate for phenol removal from wastewater",
pages = "267-271",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2012"
}

Surudžić, N., Spasojević, D., Stanković, M., Spasojević, M., Elgahwash, R. G. A., Prodanović, R.,& Prodanović, O.. (2023). Horseradish peroxidase immobilization within micro-beads of oxidized tyramine-alginate for phenol removal from wastewater. in 30th International Conference Ecological Truth and Environmental Research – EcoTER’23
University of Belgrade, Technical Faculty in Bor., 267-271.
https://hdl.handle.net/21.15107/rcub_rimsi_2012

Surudžić N, Spasojević D, Stanković M, Spasojević M, Elgahwash RGA, Prodanović R, Prodanović O. Horseradish peroxidase immobilization within micro-beads of oxidized tyramine-alginate for phenol removal from wastewater. in 30th International Conference Ecological Truth and Environmental Research – EcoTER’23. 2023;:267-271.
https://hdl.handle.net/21.15107/rcub_rimsi_2012 .

Surudžić, Nevena, Spasojević, Dragica, Stanković, Mira, Spasojević, Milica, Elgahwash, Reyadh Gomah Amar, Prodanović, Radivoje, Prodanović, Olivera, "Horseradish peroxidase immobilization within micro-beads of oxidized tyramine-alginate for phenol removal from wastewater" in 30th International Conference Ecological Truth and Environmental Research – EcoTER’23 (2023):267-271,
https://hdl.handle.net/21.15107/rcub_rimsi_2012 .

TY  - JOUR
AU  - Chen, Minjun
AU  - Kumrić, Ksenija R.
AU  - Thacker, Conner
AU  - Prodanović, Radivoje
AU  - Bolognesi, Guido
AU  - Vladisavljević, Goran T.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6394
AB  - Monodispersed polyethylene glycol diacrylate (PEGDA)/acrylic acid (AA) microgels with a tuneable negative charge and macroporous internal structure have been produced using a Lego-inspired droplet microfluidic device. The surface charge of microgels was controlled by changing the content of AA in the monomer mixture from zero (for noncharged PEGDA beads) to 4 wt%. The macroporosity of the polymer matrix was introduced by adding 20 wt% of 600-MW polyethylene glycol (PEG) as a porogen material into the monomer mixture. The porogen was successfully leached out with acetone after UV-crosslinking, which resulted in micron-sized cylindrical pores with crater-like morphology, uniformly arranged on the microgel surface. Negatively charged PEGDA/AA beads showed improved adsorption capacity towards positively charged organic dyes (methylene blue and rhodamine B) compared to neutral PEGDA beads and high repulsion of negatively charged dye molecules (methyl orange and congo red). Macroporous microgels showed better adsorption properties than nonporous beads, with a maximum adsorption capacity towards methylene blue of 45 mg/g for macroporous PEGDA/AA microgels at pH 8.6, as compared to 23 mg/g for nonporous PEGDA/AA microgels at the same pH. More than 98% of Cu(II) ions were removed from 50 ppm solution at pH 6.7 using 2.7 mg/mL of macroporous PEGDA/AA microgel. The adsorption of cationic species was significantly improved when pH was increased from 3 to 9 due to a higher degree of ionization of AA monomeric units in the polymer network. The synthesized copolymer beads can be used in drug delivery to achieve improved loading capacity of positively charged therapeutic agents and in tissue engineering, where a negative charge of scaffolds coupled with porous structure can help to achieve improved permeability of high-molecular-weight metabolites and nutrients, and anti-fouling activity against negatively charged species.
PB  - MDPI
T2  - Gels
VL  - 9
IS  - 11
SP  - 849
DO  - 10.3390/gels9110849
ER  - 

@article{
author = "Chen, Minjun and Kumrić, Ksenija R. and Thacker, Conner and Prodanović, Radivoje and Bolognesi, Guido and Vladisavljević, Goran T.",
year = "2023",
abstract = "Monodispersed polyethylene glycol diacrylate (PEGDA)/acrylic acid (AA) microgels with a tuneable negative charge and macroporous internal structure have been produced using a Lego-inspired droplet microfluidic device. The surface charge of microgels was controlled by changing the content of AA in the monomer mixture from zero (for noncharged PEGDA beads) to 4 wt%. The macroporosity of the polymer matrix was introduced by adding 20 wt% of 600-MW polyethylene glycol (PEG) as a porogen material into the monomer mixture. The porogen was successfully leached out with acetone after UV-crosslinking, which resulted in micron-sized cylindrical pores with crater-like morphology, uniformly arranged on the microgel surface. Negatively charged PEGDA/AA beads showed improved adsorption capacity towards positively charged organic dyes (methylene blue and rhodamine B) compared to neutral PEGDA beads and high repulsion of negatively charged dye molecules (methyl orange and congo red). Macroporous microgels showed better adsorption properties than nonporous beads, with a maximum adsorption capacity towards methylene blue of 45 mg/g for macroporous PEGDA/AA microgels at pH 8.6, as compared to 23 mg/g for nonporous PEGDA/AA microgels at the same pH. More than 98% of Cu(II) ions were removed from 50 ppm solution at pH 6.7 using 2.7 mg/mL of macroporous PEGDA/AA microgel. The adsorption of cationic species was significantly improved when pH was increased from 3 to 9 due to a higher degree of ionization of AA monomeric units in the polymer network. The synthesized copolymer beads can be used in drug delivery to achieve improved loading capacity of positively charged therapeutic agents and in tissue engineering, where a negative charge of scaffolds coupled with porous structure can help to achieve improved permeability of high-molecular-weight metabolites and nutrients, and anti-fouling activity against negatively charged species.",
publisher = "MDPI",
journal = "Gels",
volume = "9",
number = "11",
pages = "849",
doi = "10.3390/gels9110849"
}

Chen, M., Kumrić, K. R., Thacker, C., Prodanović, R., Bolognesi, G.,& Vladisavljević, G. T.. (2023). in Gels
MDPI., 9(11), 849.
https://doi.org/10.3390/gels9110849

Chen M, Kumrić KR, Thacker C, Prodanović R, Bolognesi G, Vladisavljević GT. in Gels. 2023;9(11):849.
doi:10.3390/gels9110849 .

Chen, Minjun, Kumrić, Ksenija R., Thacker, Conner, Prodanović, Radivoje, Bolognesi, Guido, Vladisavljević, Goran T., in Gels, 9, no. 11 (2023):849,
https://doi.org/10.3390/gels9110849 . .

TY  - JOUR
AU  - Ćeranić, Katarina
AU  - Milovanović, Branislav
AU  - Petković, Milena
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6395
PB  - Royal Society of Chemistry
T2  - Physical Chemistry Chemical Physics
T1  - Density functional theory study of crown ether–magnesium complexes: from a solvated ion to an ion trap
VL  - 25
IS  - 47
SP  - 32656
EP  - 32665
DO  - 10.1039/D3CP03991A
ER  - 

@article{
author = "Ćeranić, Katarina and Milovanović, Branislav and Petković, Milena",
year = "2023",
publisher = "Royal Society of Chemistry",
journal = "Physical Chemistry Chemical Physics",
title = "Density functional theory study of crown ether–magnesium complexes: from a solvated ion to an ion trap",
volume = "25",
number = "47",
pages = "32656-32665",
doi = "10.1039/D3CP03991A"
}

Ćeranić, K., Milovanović, B.,& Petković, M.. (2023). Density functional theory study of crown ether–magnesium complexes: from a solvated ion to an ion trap. in Physical Chemistry Chemical Physics
Royal Society of Chemistry., 25(47), 32656-32665.
https://doi.org/10.1039/D3CP03991A

Ćeranić K, Milovanović B, Petković M. Density functional theory study of crown ether–magnesium complexes: from a solvated ion to an ion trap. in Physical Chemistry Chemical Physics. 2023;25(47):32656-32665.
doi:10.1039/D3CP03991A .

Ćeranić, Katarina, Milovanović, Branislav, Petković, Milena, "Density functional theory study of crown ether–magnesium complexes: from a solvated ion to an ion trap" in Physical Chemistry Chemical Physics, 25, no. 47 (2023):32656-32665,
https://doi.org/10.1039/D3CP03991A . .

TY  - JOUR
AU  - Radić, Bojana
AU  - Radović, Radmila
AU  - Janić Hajnal, Elizabet
AU  - Mandić, Anamarija
AU  - Đekić, Sanja
AU  - Stojanović, Zorica
AU  - Kos, Jovana
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6393
AB  - Moniliformin (MON) represents one of the most widespread emerging mycotoxins, whose presence in food and feed can potentially cause harmful effects on the health of both the public and animals. In order to investigate MON occurrence, a total of four hundred (n = 400) samples of unprocessed maize were sampled from different regions (Bačka, Banat, and Srem) of Serbia during a period of four years (2018–2021) and were analyzed using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. The influence of regional differences and variations from year to year in terms of weather conditions on the occurrence of MON was also assessed. The obtained validation parameters indicated that the LC-MS/MS method is applicable to the determination of MON in maize samples. It can be observed from the acquired findings that all samples were contaminated with MON, while concentration levels varied between the samples, especially from different sampling years. The maize samples showed the greatest levels of MON concentration during the dry and hot climatic conditions experienced in 2021. In maize samples harvested in the period 2018–2020, the MON concentration levels detected were about two to three times lower compared to the year 2021. Additionally, a comprehensive investigation into the correlation between weather conditions and the occurrence of MON in maize grown in Serbia was undertaken by reviewing the outcomes of research undertaken in the past decade.
PB  - MDPI
T2  - Toxins
T1  - Moniliformin Occurrence in Serbian Maize over Four Years: Understanding Weather-Dependent Variability
VL  - 15
IS  - 11
SP  - 634
DO  - 10.3390/toxins15110634
ER  - 

@article{
author = "Radić, Bojana and Radović, Radmila and Janić Hajnal, Elizabet and Mandić, Anamarija and Đekić, Sanja and Stojanović, Zorica and Kos, Jovana",
year = "2023",
abstract = "Moniliformin (MON) represents one of the most widespread emerging mycotoxins, whose presence in food and feed can potentially cause harmful effects on the health of both the public and animals. In order to investigate MON occurrence, a total of four hundred (n = 400) samples of unprocessed maize were sampled from different regions (Bačka, Banat, and Srem) of Serbia during a period of four years (2018–2021) and were analyzed using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. The influence of regional differences and variations from year to year in terms of weather conditions on the occurrence of MON was also assessed. The obtained validation parameters indicated that the LC-MS/MS method is applicable to the determination of MON in maize samples. It can be observed from the acquired findings that all samples were contaminated with MON, while concentration levels varied between the samples, especially from different sampling years. The maize samples showed the greatest levels of MON concentration during the dry and hot climatic conditions experienced in 2021. In maize samples harvested in the period 2018–2020, the MON concentration levels detected were about two to three times lower compared to the year 2021. Additionally, a comprehensive investigation into the correlation between weather conditions and the occurrence of MON in maize grown in Serbia was undertaken by reviewing the outcomes of research undertaken in the past decade.",
publisher = "MDPI",
journal = "Toxins",
title = "Moniliformin Occurrence in Serbian Maize over Four Years: Understanding Weather-Dependent Variability",
volume = "15",
number = "11",
pages = "634",
doi = "10.3390/toxins15110634"
}

Radić, B., Radović, R., Janić Hajnal, E., Mandić, A., Đekić, S., Stojanović, Z.,& Kos, J.. (2023). Moniliformin Occurrence in Serbian Maize over Four Years: Understanding Weather-Dependent Variability. in Toxins
MDPI., 15(11), 634.
https://doi.org/10.3390/toxins15110634

Radić B, Radović R, Janić Hajnal E, Mandić A, Đekić S, Stojanović Z, Kos J. Moniliformin Occurrence in Serbian Maize over Four Years: Understanding Weather-Dependent Variability. in Toxins. 2023;15(11):634.
doi:10.3390/toxins15110634 .

Radić, Bojana, Radović, Radmila, Janić Hajnal, Elizabet, Mandić, Anamarija, Đekić, Sanja, Stojanović, Zorica, Kos, Jovana, "Moniliformin Occurrence in Serbian Maize over Four Years: Understanding Weather-Dependent Variability" in Toxins, 15, no. 11 (2023):634,
https://doi.org/10.3390/toxins15110634 . .

TY  - JOUR
AU  - Rodríguez-Castillo, María
AU  - Monge, Miguel
AU  - Holló, Berta Barta
AU  - Padrón, José M.
AU  - Puerta, Adrián
AU  - Sousa, Sérgio F.
AU  - Fernandes, Henrique S.
AU  - Blagojević, Vladimir
AU  - Višnjevac, Aleksandar
AU  - Olszewski, Mateusz
AU  - Maciejewska, Natalia
AU  - Araškov, Jovana
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5885
AB  - Thiazolyl-hydrazones (THs) exhibit a wide spectrum of biological activity that can be enhanced by complexation with various metal ions. Zn(II) complexes with α-pyridine-1,3-TH ligands may represent an alternative to the standard platinum-based chemotherapeutics. In addition, they show photoluminescence properties and thus can be regarded as multifunctional materials. In this study, we synthesized and characterized three neutral Zn(II) complexes (1–3) with pyridine-based TH ligands HLS1‒3 in order to investigate the influence of the ligands charge on the structure and intermolecular interactions in the solid state, and consequently photophysical properties. The deprotonation of the ligands mainly affects the relative energies of electronic levels in the complexes, compared to cationic counterparts, resulting in similar photoluminescence mechanisms and quantum yields with a small shift in emission energy. The influence of the substitution at the ligands’ periphery on the selected quantum molecular descriptors of the complexes is localized to the substitution site. Also, the substituents did not considerably influence the redox responses of the complexes. However, predominant spectral changes were observed in the course of the first reduction and oxidation processes which caused distinct spectral color changes indicating their possible functionality for electrochromic applications. In addition, complex 1 showed antiproliferative activity with GI50 values below 2 µM on all tested cancer cell lines.
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones
VL  - 1281
SP  - 135157
DO  - 10.1016/j.molstruc.2023.135157
ER  - 

@article{
author = "Rodríguez-Castillo, María and Monge, Miguel and Holló, Berta Barta and Padrón, José M. and Puerta, Adrián and Sousa, Sérgio F. and Fernandes, Henrique S. and Blagojević, Vladimir and Višnjevac, Aleksandar and Olszewski, Mateusz and Maciejewska, Natalia and Araškov, Jovana",
year = "2023",
abstract = "Thiazolyl-hydrazones (THs) exhibit a wide spectrum of biological activity that can be enhanced by complexation with various metal ions. Zn(II) complexes with α-pyridine-1,3-TH ligands may represent an alternative to the standard platinum-based chemotherapeutics. In addition, they show photoluminescence properties and thus can be regarded as multifunctional materials. In this study, we synthesized and characterized three neutral Zn(II) complexes (1–3) with pyridine-based TH ligands HLS1‒3 in order to investigate the influence of the ligands charge on the structure and intermolecular interactions in the solid state, and consequently photophysical properties. The deprotonation of the ligands mainly affects the relative energies of electronic levels in the complexes, compared to cationic counterparts, resulting in similar photoluminescence mechanisms and quantum yields with a small shift in emission energy. The influence of the substitution at the ligands’ periphery on the selected quantum molecular descriptors of the complexes is localized to the substitution site. Also, the substituents did not considerably influence the redox responses of the complexes. However, predominant spectral changes were observed in the course of the first reduction and oxidation processes which caused distinct spectral color changes indicating their possible functionality for electrochromic applications. In addition, complex 1 showed antiproliferative activity with GI50 values below 2 µM on all tested cancer cell lines.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones",
volume = "1281",
pages = "135157",
doi = "10.1016/j.molstruc.2023.135157"
}

Rodríguez-Castillo, M., Monge, M., Holló, B. B., Padrón, J. M., Puerta, A., Sousa, S. F., Fernandes, H. S., Blagojević, V., Višnjevac, A., Olszewski, M., Maciejewska, N.,& Araškov, J.. (2023). Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones. in Journal of Molecular Structure
Elsevier., 1281, 135157.
https://doi.org/10.1016/j.molstruc.2023.135157

Rodríguez-Castillo M, Monge M, Holló BB, Padrón JM, Puerta A, Sousa SF, Fernandes HS, Blagojević V, Višnjevac A, Olszewski M, Maciejewska N, Araškov J. Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones. in Journal of Molecular Structure. 2023;1281:135157.
doi:10.1016/j.molstruc.2023.135157 .

Rodríguez-Castillo, María, Monge, Miguel, Holló, Berta Barta, Padrón, José M., Puerta, Adrián, Sousa, Sérgio F., Fernandes, Henrique S., Blagojević, Vladimir, Višnjevac, Aleksandar, Olszewski, Mateusz, Maciejewska, Natalia, Araškov, Jovana, "Structural, physicochemical and anticancer study of Zn complexes with pyridyl-based thiazolyl-hydrazones" in Journal of Molecular Structure, 1281 (2023):135157,
https://doi.org/10.1016/j.molstruc.2023.135157 . .

TY  - JOUR
AU  - Višnjevac, Aleksandar
AU  - Araškov, Jovana
AU  - Nikolić, Milan
AU  - Bojić-Trbojević, Žanka
AU  - Pirković, Andrea
AU  - Dekanski, Dragana
AU  - Mitić, Dragana
AU  - Blagojević, Vladimir A.
AU  - Filipović, Nenad R.
AU  - Todorović, Tamara
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5877
AB  - The Zn(II) complexes [Zn(HLSe2)2](NO3)2∙CH3OH (2-NO3-Se) and [Zn(HLSe3)2](NO3)2·DMF (3-NO3-Se) with selenazolyl-hydrazone ligands 4-(4-methoxyphenyl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)-1,3-selenazole (HLSe2) and 4-(4-methylphenyl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)-1,3-selenazole (HLSe3) have been synthesized and characterized using singe crystal X-ray diffraction analysis. Antiproliferative activities of 2-NO3-Se and 3-NO3-Se, the corresponding ligands and sulphur isosteres of the complexes and the ligands were determined on non-malignant HTR-8/SVneo extravillous trophoblast cell line and malignant JEG-3 and JAr choriocarcinoma cell lines. All Zn complexes exhibited cytotoxic effect, comparable to that of a reference metal-based drug, cisplatin. The antioxidant activity of all compounds was determined in three antioxidant assays: ORAC (Oxygen Radical Absorbance Capacity), ABTS [(2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt] and CERAC [Ce(IV)-based reducing capacity]. As a result of synergy between Zn(II) and selenazolyl-hydrazone ligands, the complexes 2-NO3-Se and 3-NO3-Se appeared to be more active than Trolox, which is not the case for their sulfur counterparts. In-silico calculations of ADME properties pointed that the compounds possess some of desirable Lipinski rule principles. Applied algorithms did not report the compounds as potential PAINS or covalent inhibitors, although due to high molecular weight none of the compounds represent a potential lead compound. Toxicity prediction of the compounds is performed using machine learning models. The complexation of the ligands most likely reduces their toxicity or reduces their negative metabolic effects.
PB  - Elsevier
T2  - Journal of Molecular Structure
T2  - Journal of Molecular StructureJournal of Molecular Structure
T1  - Zn(II) complexes with pyridyl-based 1,3-selen/thiazolyl-hydrazones: A comparative study
VL  - 1281
SP  - 135193
DO  - 10.1016/j.molstruc.2023.135193
ER  - 

@article{
author = "Višnjevac, Aleksandar and Araškov, Jovana and Nikolić, Milan and Bojić-Trbojević, Žanka and Pirković, Andrea and Dekanski, Dragana and Mitić, Dragana and Blagojević, Vladimir A. and Filipović, Nenad R. and Todorović, Tamara",
year = "2023",
abstract = "The Zn(II) complexes [Zn(HLSe2)2](NO3)2∙CH3OH (2-NO3-Se) and [Zn(HLSe3)2](NO3)2·DMF (3-NO3-Se) with selenazolyl-hydrazone ligands 4-(4-methoxyphenyl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)-1,3-selenazole (HLSe2) and 4-(4-methylphenyl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)-1,3-selenazole (HLSe3) have been synthesized and characterized using singe crystal X-ray diffraction analysis. Antiproliferative activities of 2-NO3-Se and 3-NO3-Se, the corresponding ligands and sulphur isosteres of the complexes and the ligands were determined on non-malignant HTR-8/SVneo extravillous trophoblast cell line and malignant JEG-3 and JAr choriocarcinoma cell lines. All Zn complexes exhibited cytotoxic effect, comparable to that of a reference metal-based drug, cisplatin. The antioxidant activity of all compounds was determined in three antioxidant assays: ORAC (Oxygen Radical Absorbance Capacity), ABTS [(2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt] and CERAC [Ce(IV)-based reducing capacity]. As a result of synergy between Zn(II) and selenazolyl-hydrazone ligands, the complexes 2-NO3-Se and 3-NO3-Se appeared to be more active than Trolox, which is not the case for their sulfur counterparts. In-silico calculations of ADME properties pointed that the compounds possess some of desirable Lipinski rule principles. Applied algorithms did not report the compounds as potential PAINS or covalent inhibitors, although due to high molecular weight none of the compounds represent a potential lead compound. Toxicity prediction of the compounds is performed using machine learning models. The complexation of the ligands most likely reduces their toxicity or reduces their negative metabolic effects.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure, Journal of Molecular StructureJournal of Molecular Structure",
title = "Zn(II) complexes with pyridyl-based 1,3-selen/thiazolyl-hydrazones: A comparative study",
volume = "1281",
pages = "135193",
doi = "10.1016/j.molstruc.2023.135193"
}

Višnjevac, A., Araškov, J., Nikolić, M., Bojić-Trbojević, Ž., Pirković, A., Dekanski, D., Mitić, D., Blagojević, V. A., Filipović, N. R.,& Todorović, T.. (2023). Zn(II) complexes with pyridyl-based 1,3-selen/thiazolyl-hydrazones: A comparative study. in Journal of Molecular Structure
Elsevier., 1281, 135193.
https://doi.org/10.1016/j.molstruc.2023.135193

Višnjevac A, Araškov J, Nikolić M, Bojić-Trbojević Ž, Pirković A, Dekanski D, Mitić D, Blagojević VA, Filipović NR, Todorović T. Zn(II) complexes with pyridyl-based 1,3-selen/thiazolyl-hydrazones: A comparative study. in Journal of Molecular Structure. 2023;1281:135193.
doi:10.1016/j.molstruc.2023.135193 .

Višnjevac, Aleksandar, Araškov, Jovana, Nikolić, Milan, Bojić-Trbojević, Žanka, Pirković, Andrea, Dekanski, Dragana, Mitić, Dragana, Blagojević, Vladimir A., Filipović, Nenad R., Todorović, Tamara, "Zn(II) complexes with pyridyl-based 1,3-selen/thiazolyl-hydrazones: A comparative study" in Journal of Molecular Structure, 1281 (2023):135193,
https://doi.org/10.1016/j.molstruc.2023.135193 . .

TY  - CONF
AU  - Ristić, Predrag
AU  - Višnjevac, Aleksandar
AU  - Araškov, Jovana
AU  - Filipović, Nenad
AU  - Todorović, Tamara
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6004
AB  - Због своје могућности да оствари координационе бројеве од 2 до 9, високе биодоступност и афинитета према N, O, S-донорским атомима, Zn(II) се користи за синтезе комплекса у циљу њихове специфичне примене. У Кембричкој структурној бази података је депоновано само осам кристалних структура комплекса Zn(II), Cd(II) и Co(III) са 
N-хетероароматичним 1,3-селеназолил-хидразонским лигандима. У овом раду је  фокус био на кристалној структури комплекса Zn(II) са лигандом HLSe2 (2-Cl-Se; Слика 1). Молекулска и кристална структура новог комплекса 2-Cl-Se је упоређена са претходно објављеним Zn(II) комплексом са лигандом HLS2 (2-Cl), структурним аналогом лиганда HLSe2 [1]. Праћен утицај изостерне S/Se замене на топологију и енергетску дистрибуцију интермолекулских интеракција у Zn(II) комплексима са 1,3-селеназолил/тиазолил-хидразонима на бази пиридина.
AB  - Due to its ability to achieve coordination numbers from 2 to 9, high bioavail-ability, and affinity to N, O, and S-donor atoms, Zn(II) is used for the syn-thesis of complexes with the aim of their specific application. Only eight crystal structures of Zn(II), Cd(II), and Co(III) complexes with N-heteroaromatic 1,3-selenazolyl-hydrazone ligands are deposited in the Cam-bridge Structural Database. This work focused on the crystal structure of the Zn(II) complex with the HLSe2 ligand (2-Cl-Se; Figure 1). The molecular and crystal structure of the new 2-Cl-Se complex was compared with the previ-ously published Zn(II) complex with the HLS2 ligand (2-Cl), a structural analog of the HLSe2 ligand [1]. The influence of isosteric S/Se substitution on the topology and energy distribution of intermolecular interactions in Zn(II) complexes with pyridine-based 1,3-selenazolyl/thiazolyl-hydrazones was monitored [1].
PB  - Belgrade : Serbian Crystallographic Society
C3  - 28th Conference of the Serbian Crystallographic Society, Čačak, Serbia, June 14–15, 2023
T1  - Zn(II) complex with pyridine based 1,3-selenazolyl-hydrazone
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6004
ER  - 

@conference{
author = "Ristić, Predrag and Višnjevac, Aleksandar and Araškov, Jovana and Filipović, Nenad and Todorović, Tamara",
year = "2023",
abstract = "Због своје могућности да оствари координационе бројеве од 2 до 9, високе биодоступност и афинитета према N, O, S-донорским атомима, Zn(II) се користи за синтезе комплекса у циљу њихове специфичне примене. У Кембричкој структурној бази података је депоновано само осам кристалних структура комплекса Zn(II), Cd(II) и Co(III) са 
N-хетероароматичним 1,3-селеназолил-хидразонским лигандима. У овом раду је  фокус био на кристалној структури комплекса Zn(II) са лигандом HLSe2 (2-Cl-Se; Слика 1). Молекулска и кристална структура новог комплекса 2-Cl-Se је упоређена са претходно објављеним Zn(II) комплексом са лигандом HLS2 (2-Cl), структурним аналогом лиганда HLSe2 [1]. Праћен утицај изостерне S/Se замене на топологију и енергетску дистрибуцију интермолекулских интеракција у Zn(II) комплексима са 1,3-селеназолил/тиазолил-хидразонима на бази пиридина., Due to its ability to achieve coordination numbers from 2 to 9, high bioavail-ability, and affinity to N, O, and S-donor atoms, Zn(II) is used for the syn-thesis of complexes with the aim of their specific application. Only eight crystal structures of Zn(II), Cd(II), and Co(III) complexes with N-heteroaromatic 1,3-selenazolyl-hydrazone ligands are deposited in the Cam-bridge Structural Database. This work focused on the crystal structure of the Zn(II) complex with the HLSe2 ligand (2-Cl-Se; Figure 1). The molecular and crystal structure of the new 2-Cl-Se complex was compared with the previ-ously published Zn(II) complex with the HLS2 ligand (2-Cl), a structural analog of the HLSe2 ligand [1]. The influence of isosteric S/Se substitution on the topology and energy distribution of intermolecular interactions in Zn(II) complexes with pyridine-based 1,3-selenazolyl/thiazolyl-hydrazones was monitored [1].",
publisher = "Belgrade : Serbian Crystallographic Society",
journal = "28th Conference of the Serbian Crystallographic Society, Čačak, Serbia, June 14–15, 2023",
title = "Zn(II) complex with pyridine based 1,3-selenazolyl-hydrazone",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6004"
}

Ristić, P., Višnjevac, A., Araškov, J., Filipović, N.,& Todorović, T.. (2023). Zn(II) complex with pyridine based 1,3-selenazolyl-hydrazone. in 28th Conference of the Serbian Crystallographic Society, Čačak, Serbia, June 14–15, 2023
Belgrade : Serbian Crystallographic Society..
https://hdl.handle.net/21.15107/rcub_cherry_6004

Ristić P, Višnjevac A, Araškov J, Filipović N, Todorović T. Zn(II) complex with pyridine based 1,3-selenazolyl-hydrazone. in 28th Conference of the Serbian Crystallographic Society, Čačak, Serbia, June 14–15, 2023. 2023;.
https://hdl.handle.net/21.15107/rcub_cherry_6004 .

Ristić, Predrag, Višnjevac, Aleksandar, Araškov, Jovana, Filipović, Nenad, Todorović, Tamara, "Zn(II) complex with pyridine based 1,3-selenazolyl-hydrazone" in 28th Conference of the Serbian Crystallographic Society, Čačak, Serbia, June 14–15, 2023 (2023),
https://hdl.handle.net/21.15107/rcub_cherry_6004 .

TY  - CONF
AU  - Araškov, Jovana
AU  - Ristić, Predrag
AU  - Višnjevac, Aleksandar
AU  - López-de-Luzuriaga, Jose Marija
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6005
AB  - Јефтина, нискотоксична координациона једињења Zn(II) представљају обећавајуће кандидате за различите примене, укључујући фотолуминесцентне материјале. У овом раду су представљена два комплекса Zn(II) са хидразонил-тиазолским лигандима на бази пиридина (HLS1 и HLS2), који су синтетсани директном реакцијом лиганaда и Zn(CH3COO)2∙2H2O. Пентануклеарни комплекс [Zn5(HLS1)4(CH3COO)6] (1-AcO; Слика 1) кристалише у моноклиничној P21/n просторној групи са половином молекула по асиметричној јединици, при чему се централни јон Zn(II) налази на центру инверзије (Викофово слово c). Мононуклеарни комплекс [Zn(HLS2)(CH3COO)(H2O)] (2-AcO; Слика 2) кристалише у триклиничној P¬–1 просторној групи са једним молекулом по асиметричној јединици. Експеримент дифракције X-зрака са узорка праха je потврдио да су добијени једнофазни производи. Урађена је детаљна анализа типова и енергетске дистрибуције интермолекулских интеракција. Симетричан комплекс 1-AcO није фотолуминесцентан, за разлику од комплекса 2-AcO. Квантно-механички прорачуни теорије функционала густине (DFT) и временски зависне теорије функционала густине (TD-DFT) су расветлили порекло фотолуминесцентних својстава комплекса 2-AcO.
AB  - Inexpensive, low-toxic Zn(II) coordination compounds are represent promising candidates for various applications, including photoluminescent materials. In this study we report two zinc(II) complexes with thiazolyl-hydrazone-based ligands (HLS1 and HLS2), which were synthesized by direct reaction of the ligands with Zn(CH3COO)2∙2H2O. Pentanuclear complex [Zn5(HLS1)4(CH3COO)6] (1-AcO; Figure 1) crystalizes in monoclinic P21/n space group with half of the molecule in the asymmetric unit, where Zn3 atoms lie at inversion center (Wyckoff letter c). Mononuclear [Zn(HLS2)(CH3COO)(H2O)] (2-AcO; Figure 2) crystalizes in triclinic P‒1 space group with one molecule in the asymmetric unit (Figure 2). Powder X-ray diffraction experiments confirmed that single-phase products were obtained. A detailed analysis of types and energy distribution of intermolecular interactions was performed. The symmetrical 1-AcO does not exhibit photophysical properties, unlike asymmetrical 2-AcO. Quantum-mechanical calculations of density functional theory (DFT) and time-dependent DFT provided insight into origin of the photoluminescent properties of 2-AcO.
PB  - Belgrade : Serbian Crystallographic Society
C3  - 28th Conference of the Serbian Crystallographic Society, Čačak, Serbia, June 14–15, 2023
T1  - Mononuclear and pentanuclear Zn(II) complexes with hydrazonyl-thiazoles: structural and photophisical study
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6005
ER  - 

@conference{
author = "Araškov, Jovana and Ristić, Predrag and Višnjevac, Aleksandar and López-de-Luzuriaga, Jose Marija",
year = "2023",
abstract = "Јефтина, нискотоксична координациона једињења Zn(II) представљају обећавајуће кандидате за различите примене, укључујући фотолуминесцентне материјале. У овом раду су представљена два комплекса Zn(II) са хидразонил-тиазолским лигандима на бази пиридина (HLS1 и HLS2), који су синтетсани директном реакцијом лиганaда и Zn(CH3COO)2∙2H2O. Пентануклеарни комплекс [Zn5(HLS1)4(CH3COO)6] (1-AcO; Слика 1) кристалише у моноклиничној P21/n просторној групи са половином молекула по асиметричној јединици, при чему се централни јон Zn(II) налази на центру инверзије (Викофово слово c). Мононуклеарни комплекс [Zn(HLS2)(CH3COO)(H2O)] (2-AcO; Слика 2) кристалише у триклиничној P¬–1 просторној групи са једним молекулом по асиметричној јединици. Експеримент дифракције X-зрака са узорка праха je потврдио да су добијени једнофазни производи. Урађена је детаљна анализа типова и енергетске дистрибуције интермолекулских интеракција. Симетричан комплекс 1-AcO није фотолуминесцентан, за разлику од комплекса 2-AcO. Квантно-механички прорачуни теорије функционала густине (DFT) и временски зависне теорије функционала густине (TD-DFT) су расветлили порекло фотолуминесцентних својстава комплекса 2-AcO., Inexpensive, low-toxic Zn(II) coordination compounds are represent promising candidates for various applications, including photoluminescent materials. In this study we report two zinc(II) complexes with thiazolyl-hydrazone-based ligands (HLS1 and HLS2), which were synthesized by direct reaction of the ligands with Zn(CH3COO)2∙2H2O. Pentanuclear complex [Zn5(HLS1)4(CH3COO)6] (1-AcO; Figure 1) crystalizes in monoclinic P21/n space group with half of the molecule in the asymmetric unit, where Zn3 atoms lie at inversion center (Wyckoff letter c). Mononuclear [Zn(HLS2)(CH3COO)(H2O)] (2-AcO; Figure 2) crystalizes in triclinic P‒1 space group with one molecule in the asymmetric unit (Figure 2). Powder X-ray diffraction experiments confirmed that single-phase products were obtained. A detailed analysis of types and energy distribution of intermolecular interactions was performed. The symmetrical 1-AcO does not exhibit photophysical properties, unlike asymmetrical 2-AcO. Quantum-mechanical calculations of density functional theory (DFT) and time-dependent DFT provided insight into origin of the photoluminescent properties of 2-AcO.",
publisher = "Belgrade : Serbian Crystallographic Society",
journal = "28th Conference of the Serbian Crystallographic Society, Čačak, Serbia, June 14–15, 2023",
title = "Mononuclear and pentanuclear Zn(II) complexes with hydrazonyl-thiazoles: structural and photophisical study",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6005"
}

Araškov, J., Ristić, P., Višnjevac, A.,& López-de-Luzuriaga, J. M.. (2023). Mononuclear and pentanuclear Zn(II) complexes with hydrazonyl-thiazoles: structural and photophisical study. in 28th Conference of the Serbian Crystallographic Society, Čačak, Serbia, June 14–15, 2023
Belgrade : Serbian Crystallographic Society..
https://hdl.handle.net/21.15107/rcub_cherry_6005

Araškov J, Ristić P, Višnjevac A, López-de-Luzuriaga JM. Mononuclear and pentanuclear Zn(II) complexes with hydrazonyl-thiazoles: structural and photophisical study. in 28th Conference of the Serbian Crystallographic Society, Čačak, Serbia, June 14–15, 2023. 2023;.
https://hdl.handle.net/21.15107/rcub_cherry_6005 .

Araškov, Jovana, Ristić, Predrag, Višnjevac, Aleksandar, López-de-Luzuriaga, Jose Marija, "Mononuclear and pentanuclear Zn(II) complexes with hydrazonyl-thiazoles: structural and photophisical study" in 28th Conference of the Serbian Crystallographic Society, Čačak, Serbia, June 14–15, 2023 (2023),
https://hdl.handle.net/21.15107/rcub_cherry_6005 .

TY  - JOUR
AU  - Araškov, Jovana
AU  - Ristić, Predrag
AU  - Višnjevac, Aleksandar
AU  - Mitić, Dragana
AU  - Andrej, Milivojac
AU  - Filipović, Nenad
AU  - Todorović, Tamara
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6317
AB  - An octahedral complex of Zn(II) with a ligand from a class of pyridine-based 1,3-selenazolyl-hydrazones was synthesized and characterized by IR and NMR spectroscopy and single crystal X-ray diffraction analysis. The purity of the complex was confirmed by elemental analysis. Two ligands are coordinated in the neutral NNN-tridentate form forming a complex cation, while the positive charge is neutralized by [ZnCl4]2–. Complex crystallizes in monoclinic C2/c space group with the Zn atoms situated in a special position. The packing features of the novel complex were analyzed using Hirshfeld surfaces, construction of 2D pseudosymmetric plot and DFT quantum mechanical calculations and compared with the previously published sulfur-based isostere. The key difference in the structures, imposed by replacement of sulfur with selenium, were identified.
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Zn(II) complex with pyridine based 1,3-selenazolyl-hydrazone: Synthesis, structural characterization and DFT study
VL  - n/a
DO  - 10.2298/JSC230831079A
ER  - 

@article{
author = "Araškov, Jovana and Ristić, Predrag and Višnjevac, Aleksandar and Mitić, Dragana and Andrej, Milivojac and Filipović, Nenad and Todorović, Tamara",
year = "2023",
abstract = "An octahedral complex of Zn(II) with a ligand from a class of pyridine-based 1,3-selenazolyl-hydrazones was synthesized and characterized by IR and NMR spectroscopy and single crystal X-ray diffraction analysis. The purity of the complex was confirmed by elemental analysis. Two ligands are coordinated in the neutral NNN-tridentate form forming a complex cation, while the positive charge is neutralized by [ZnCl4]2–. Complex crystallizes in monoclinic C2/c space group with the Zn atoms situated in a special position. The packing features of the novel complex were analyzed using Hirshfeld surfaces, construction of 2D pseudosymmetric plot and DFT quantum mechanical calculations and compared with the previously published sulfur-based isostere. The key difference in the structures, imposed by replacement of sulfur with selenium, were identified.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Zn(II) complex with pyridine based 1,3-selenazolyl-hydrazone: Synthesis, structural characterization and DFT study",
volume = "n/a",
doi = "10.2298/JSC230831079A"
}

Araškov, J., Ristić, P., Višnjevac, A., Mitić, D., Andrej, M., Filipović, N.,& Todorović, T.. (2023). Zn(II) complex with pyridine based 1,3-selenazolyl-hydrazone: Synthesis, structural characterization and DFT study. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., n/a.
https://doi.org/10.2298/JSC230831079A

Araškov J, Ristić P, Višnjevac A, Mitić D, Andrej M, Filipović N, Todorović T. Zn(II) complex with pyridine based 1,3-selenazolyl-hydrazone: Synthesis, structural characterization and DFT study. in Journal of the Serbian Chemical Society. 2023;n/a.
doi:10.2298/JSC230831079A .

Araškov, Jovana, Ristić, Predrag, Višnjevac, Aleksandar, Mitić, Dragana, Andrej, Milivojac, Filipović, Nenad, Todorović, Tamara, "Zn(II) complex with pyridine based 1,3-selenazolyl-hydrazone: Synthesis, structural characterization and DFT study" in Journal of the Serbian Chemical Society, n/a (2023),
https://doi.org/10.2298/JSC230831079A . .

TY  - JOUR
AU  - Ivanović, Tijana
AU  - Popović, Daniela Ž.
AU  - Miladinović, Jelena
AU  - Miladinović, Zoran P.
AU  - Pastor, Ferenc
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6090
AB  - Zero-current cell potential measurements were used to determine the solution activity coefficient in a ternary system {yKCl + (1 – y) KH2PO4}(aq) at temperature T = 298.15 K. The cell of the type K–ISE|KCl(mKCl), KH2PO4(mKH2PO4)|Ag|AgCl was used in the total ionic strength range, Im = 0.0886–1.0046 mol kg–1. In order to generate a set of parameters that can be applied in a wide range of mixed solution ionic strengths, the Pitzer, Scatchard, and Clegg–Pitzer–Brimblecombe models were used to fit all available experimental data, including cell potential and isopiestic measurements from the literature. The experimental and calculated values of thermodynamic properties for the studied system are in excellent agreement. Potential interactions and solution structure were discussed by means of the excess free energy of mixing via potential pairs, triplets, or quads for the investigated solution using the Scatchard model mixing parameters.
PB  - American Chemical Society
T2  - Journal of Chemical & Engineering Data
T1  - Activity Coefficients of the System {yKCl + (1 – y)KH2PO4}(aq) at T = 298.15 K Determined by Cell Potential Measurements
VL  - 68
IS  - 2
SP  - 405
EP  - 415
DO  - 10.1021/acs.jced.2c00704
ER  - 

@article{
author = "Ivanović, Tijana and Popović, Daniela Ž. and Miladinović, Jelena and Miladinović, Zoran P. and Pastor, Ferenc",
year = "2023",
abstract = "Zero-current cell potential measurements were used to determine the solution activity coefficient in a ternary system {yKCl + (1 – y) KH2PO4}(aq) at temperature T = 298.15 K. The cell of the type K–ISE|KCl(mKCl), KH2PO4(mKH2PO4)|Ag|AgCl was used in the total ionic strength range, Im = 0.0886–1.0046 mol kg–1. In order to generate a set of parameters that can be applied in a wide range of mixed solution ionic strengths, the Pitzer, Scatchard, and Clegg–Pitzer–Brimblecombe models were used to fit all available experimental data, including cell potential and isopiestic measurements from the literature. The experimental and calculated values of thermodynamic properties for the studied system are in excellent agreement. Potential interactions and solution structure were discussed by means of the excess free energy of mixing via potential pairs, triplets, or quads for the investigated solution using the Scatchard model mixing parameters.",
publisher = "American Chemical Society",
journal = "Journal of Chemical & Engineering Data",
title = "Activity Coefficients of the System {yKCl + (1 – y)KH2PO4}(aq) at T = 298.15 K Determined by Cell Potential Measurements",
volume = "68",
number = "2",
pages = "405-415",
doi = "10.1021/acs.jced.2c00704"
}

Ivanović, T., Popović, D. Ž., Miladinović, J., Miladinović, Z. P.,& Pastor, F.. (2023). Activity Coefficients of the System {yKCl + (1 – y)KH2PO4}(aq) at T = 298.15 K Determined by Cell Potential Measurements. in Journal of Chemical & Engineering Data
American Chemical Society., 68(2), 405-415.
https://doi.org/10.1021/acs.jced.2c00704

Ivanović T, Popović DŽ, Miladinović J, Miladinović ZP, Pastor F. Activity Coefficients of the System {yKCl + (1 – y)KH2PO4}(aq) at T = 298.15 K Determined by Cell Potential Measurements. in Journal of Chemical & Engineering Data. 2023;68(2):405-415.
doi:10.1021/acs.jced.2c00704 .

Ivanović, Tijana, Popović, Daniela Ž., Miladinović, Jelena, Miladinović, Zoran P., Pastor, Ferenc, "Activity Coefficients of the System {yKCl + (1 – y)KH2PO4}(aq) at T = 298.15 K Determined by Cell Potential Measurements" in Journal of Chemical & Engineering Data, 68, no. 2 (2023):405-415,
https://doi.org/10.1021/acs.jced.2c00704 . .

TY  - JOUR
AU  - Simić, Katarina
AU  - Miladinović, Zoran P.
AU  - Todorović, Nina
AU  - Trifunović, Snežana S.
AU  - Avramović, Nataša
AU  - Gavrilović, Aleksandra
AU  - Jovanović, Silvana
AU  - Gođevac, Dejan
AU  - Vujisić, Ljubodrag V.
AU  - Tešević, Vele
AU  - Tasić, Ljubica
AU  - Mandić, Boris
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6261
AB  - Bipolar disorder (BD) is a brain disorder that causes changes in a person’s mood, energy, and ability to function. It has a prevalence of 60 million people worldwide, and it is among the top 20 diseases with the highest global burden. The complexity of this disease, including diverse genetic, environmental, and biochemical factors, and diagnoses based on the subjective recognition of symptoms without any clinical test of biomarker identification create significant difficulties in understanding and diagnosing BD. A 1H-NMR-based metabolomic study applying chemometrics of serum samples of Serbian patients with BD (33) and healthy controls (39) was explored, providing the identification of 22 metabolites for this disease. A biomarker set including threonine, aspartate, gamma-aminobutyric acid, 2-hydroxybutyric acid, serine, and mannose was established for the first time in BD serum samples by an NMR-based metabolomics study. Six identified metabolites (3-hydroxybutyric acid, arginine, lysine, tyrosine, phenylalanine, and glycerol) are in agreement with the previously determined NMR-based sets of serum biomarkers in Brazilian and/or Chinese patient samples. The same established metabolites (lactate, alanine, valine, leucine, isoleucine, glutamine, glutamate, glucose, and choline) in three different ethnic and geographic origins (Serbia, Brazil, and China) might have a crucial role in the realization of a universal set of NMR biomarkers for BD.
PB  - MDPI
T2  - Metabolites
T1  - Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients
VL  - 13
IS  - 5
SP  - 607
DO  - 10.3390/metabo13050607
ER  - 

@article{
author = "Simić, Katarina and Miladinović, Zoran P. and Todorović, Nina and Trifunović, Snežana S. and Avramović, Nataša and Gavrilović, Aleksandra and Jovanović, Silvana and Gođevac, Dejan and Vujisić, Ljubodrag V. and Tešević, Vele and Tasić, Ljubica and Mandić, Boris",
year = "2023",
abstract = "Bipolar disorder (BD) is a brain disorder that causes changes in a person’s mood, energy, and ability to function. It has a prevalence of 60 million people worldwide, and it is among the top 20 diseases with the highest global burden. The complexity of this disease, including diverse genetic, environmental, and biochemical factors, and diagnoses based on the subjective recognition of symptoms without any clinical test of biomarker identification create significant difficulties in understanding and diagnosing BD. A 1H-NMR-based metabolomic study applying chemometrics of serum samples of Serbian patients with BD (33) and healthy controls (39) was explored, providing the identification of 22 metabolites for this disease. A biomarker set including threonine, aspartate, gamma-aminobutyric acid, 2-hydroxybutyric acid, serine, and mannose was established for the first time in BD serum samples by an NMR-based metabolomics study. Six identified metabolites (3-hydroxybutyric acid, arginine, lysine, tyrosine, phenylalanine, and glycerol) are in agreement with the previously determined NMR-based sets of serum biomarkers in Brazilian and/or Chinese patient samples. The same established metabolites (lactate, alanine, valine, leucine, isoleucine, glutamine, glutamate, glucose, and choline) in three different ethnic and geographic origins (Serbia, Brazil, and China) might have a crucial role in the realization of a universal set of NMR biomarkers for BD.",
publisher = "MDPI",
journal = "Metabolites",
title = "Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients",
volume = "13",
number = "5",
pages = "607",
doi = "10.3390/metabo13050607"
}

Simić, K., Miladinović, Z. P., Todorović, N., Trifunović, S. S., Avramović, N., Gavrilović, A., Jovanović, S., Gođevac, D., Vujisić, L. V., Tešević, V., Tasić, L.,& Mandić, B.. (2023). Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients. in Metabolites
MDPI., 13(5), 607.
https://doi.org/10.3390/metabo13050607

Simić K, Miladinović ZP, Todorović N, Trifunović SS, Avramović N, Gavrilović A, Jovanović S, Gođevac D, Vujisić LV, Tešević V, Tasić L, Mandić B. Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients. in Metabolites. 2023;13(5):607.
doi:10.3390/metabo13050607 .

Simić, Katarina, Miladinović, Zoran P., Todorović, Nina, Trifunović, Snežana S., Avramović, Nataša, Gavrilović, Aleksandra, Jovanović, Silvana, Gođevac, Dejan, Vujisić, Ljubodrag V., Tešević, Vele, Tasić, Ljubica, Mandić, Boris, "Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients" in Metabolites, 13, no. 5 (2023):607,
https://doi.org/10.3390/metabo13050607 . .

TY  - JOUR
AU  - Jadranin, Milka
AU  - Avramović, Nataša
AU  - Miladinović, Zoran
AU  - Gavrilović, Aleksandra
AU  - Tasic, Ljubica
AU  - Tešević, Vele
AU  - Mandić, Boris
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6391
AB  - The Lipidomic profiles of serum samples from patients with bipolar disorder (BD) and healthy controls (C) were explored and compared. The sample cohort included 31 BD patients and 31 control individuals. An untargeted lipidomics study applying liquid chromatography (LC) coupled with high-resolution mass spectrometry (HRMS) was conducted to achieve the lipid profiles. Multivariate statistical analyses (principal component analysis and partial least squares discriminant analysis) were performed, and fifty-six differential lipids were confirmed in BD and controls. Our results pointed to alterations in lipid metabolism, including pathways of glycerophospholipids, sphingolipids, glycerolipids, and sterol lipids, in BD patient sera. This study emphasized the role of lipid pathways in BD, and comprehensive research using the LC-HRMS platform is necessary for future application in the diagnosis and improvement of BD treatments.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia
VL  - 24
IS  - 22
SP  - 16025
DO  - 10.3390/ijms242216025
ER  - 

@article{
author = "Jadranin, Milka and Avramović, Nataša and Miladinović, Zoran and Gavrilović, Aleksandra and Tasic, Ljubica and Tešević, Vele and Mandić, Boris",
year = "2023",
abstract = "The Lipidomic profiles of serum samples from patients with bipolar disorder (BD) and healthy controls (C) were explored and compared. The sample cohort included 31 BD patients and 31 control individuals. An untargeted lipidomics study applying liquid chromatography (LC) coupled with high-resolution mass spectrometry (HRMS) was conducted to achieve the lipid profiles. Multivariate statistical analyses (principal component analysis and partial least squares discriminant analysis) were performed, and fifty-six differential lipids were confirmed in BD and controls. Our results pointed to alterations in lipid metabolism, including pathways of glycerophospholipids, sphingolipids, glycerolipids, and sterol lipids, in BD patient sera. This study emphasized the role of lipid pathways in BD, and comprehensive research using the LC-HRMS platform is necessary for future application in the diagnosis and improvement of BD treatments.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia",
volume = "24",
number = "22",
pages = "16025",
doi = "10.3390/ijms242216025"
}

Jadranin, M., Avramović, N., Miladinović, Z., Gavrilović, A., Tasic, L., Tešević, V.,& Mandić, B.. (2023). Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia. in International Journal of Molecular Sciences
MDPI., 24(22), 16025.
https://doi.org/10.3390/ijms242216025

Jadranin M, Avramović N, Miladinović Z, Gavrilović A, Tasic L, Tešević V, Mandić B. Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia. in International Journal of Molecular Sciences. 2023;24(22):16025.
doi:10.3390/ijms242216025 .

Jadranin, Milka, Avramović, Nataša, Miladinović, Zoran, Gavrilović, Aleksandra, Tasic, Ljubica, Tešević, Vele, Mandić, Boris, "Untargeted Lipidomics Study of Bipolar Disorder Patients in Serbia" in International Journal of Molecular Sciences, 24, no. 22 (2023):16025,
https://doi.org/10.3390/ijms242216025 . .

TY  - JOUR
AU  - Glušač, Ksenija D.
AU  - Saičić, Radomir
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6193
AB  - Does the pursuit of scientific research based on a well-defined technological outcome hamper our ability to be creative? And does it limit opportunities to explore and develop fundamental areas of science that may ultimately lead to applications we hadn’t even thought of yet?
PB  - Nature Research
T2  - Nature Chemistry
T1  - Are science and technology friends or foes?
VL  - 15
IS  - 4
SP  - 439
EP  - 442
DO  - 10.1038/s41557-023-01171-8
ER  - 

@article{
author = "Glušač, Ksenija D. and Saičić, Radomir",
year = "2023",
abstract = "Does the pursuit of scientific research based on a well-defined technological outcome hamper our ability to be creative? And does it limit opportunities to explore and develop fundamental areas of science that may ultimately lead to applications we hadn’t even thought of yet?",
publisher = "Nature Research",
journal = "Nature Chemistry",
title = "Are science and technology friends or foes?",
volume = "15",
number = "4",
pages = "439-442",
doi = "10.1038/s41557-023-01171-8"
}

Glušač, K. D.,& Saičić, R.. (2023). Are science and technology friends or foes?. in Nature Chemistry
Nature Research., 15(4), 439-442.
https://doi.org/10.1038/s41557-023-01171-8

Glušač KD, Saičić R. Are science and technology friends or foes?. in Nature Chemistry. 2023;15(4):439-442.
doi:10.1038/s41557-023-01171-8 .

Glušač, Ksenija D., Saičić, Radomir, "Are science and technology friends or foes?" in Nature Chemistry, 15, no. 4 (2023):439-442,
https://doi.org/10.1038/s41557-023-01171-8 . .