TY  - DATA
AU  - Đurđić, Slađana
AU  - Vlahović, Filip
AU  - Markićević, Milan
AU  - Mutić, Jelena
AU  - Manojlović, Dragan D.
AU  - Stanković, Vesna
AU  - Švorc, Ľubomír
AU  - Stanković, Dalibor
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5812
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5839
AB  - Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.
PB  - MDPI
T2  - Chemosensors
T1  - Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015
VL  - 11
IS  - 1
SP  - 15
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5839
ER  - 

@misc{
author = "Đurđić, Slađana and Vlahović, Filip and Markićević, Milan and Mutić, Jelena and Manojlović, Dragan D. and Stanković, Vesna and Švorc, Ľubomír and Stanković, Dalibor",
abstract = "Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.",
publisher = "MDPI",
journal = "Chemosensors",
title = "Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015",
volume = "11",
number = "1",
pages = "15",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5839"
}

Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D. D., Stanković, V., Švorc, Ľ.,& Stanković, D..Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015. in Chemosensors
MDPI., 11(1), 15.
https://hdl.handle.net/21.15107/rcub_cherry_5839

Đurđić S, Vlahović F, Markićević M, Mutić J, Manojlović DD, Stanković V, Švorc Ľ, Stanković D. Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015. in Chemosensors.11(1):15.
https://hdl.handle.net/21.15107/rcub_cherry_5839 .

Đurđić, Slađana, Vlahović, Filip, Markićević, Milan, Mutić, Jelena, Manojlović, Dragan D., Stanković, Vesna, Švorc, Ľubomír, Stanković, Dalibor, "Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015" in Chemosensors, 11, no. 1:15,
https://hdl.handle.net/21.15107/rcub_cherry_5839 .

TY  - DATA
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Bošković, Jakša
AU  - Baranac-Stojanović, Marija
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5846
AB  - We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.
PB  - Royal Society of Chemistry
T2  - Organic & Biomolecular Chemistry
T1  - Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F
VL  - 21
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5846
ER  - 

@misc{
author = "Aleksić, Jovana and Stojanović, Milovan and Bošković, Jakša and Baranac-Stojanović, Marija",
abstract = "We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.",
publisher = "Royal Society of Chemistry",
journal = "Organic & Biomolecular Chemistry",
title = "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F",
volume = "21",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5846"
}

Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M..Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846

Aleksić J, Stojanović M, Bošković J, Baranac-Stojanović M. Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry.21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

Aleksić, Jovana, Stojanović, Milovan, Bošković, Jakša, Baranac-Stojanović, Marija, "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F" in Organic & Biomolecular Chemistry, 21, no. 6,
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana 
AU  - Kostić-Rajačić, Slađana
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 

@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana  and Kostić-Rajačić, Slađana",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}

Penjišević, J., Šukalović, V., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D.,& Kostić-Rajačić, S..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845

Penjišević J, Šukalović V, Dukić-Stefanović S, Deuther-Conrad W, Andrić D, Kostić-Rajačić S. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

Penjišević, Jelena , Šukalović, Vladimir , Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana , Kostić-Rajačić, Slađana, "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

TY  - JOUR
AU  - Sofrenić, Ivana
AU  - Anđelković, Boban D.
AU  - Gođevac, Dejan
AU  - Ivanović, Stefan
AU  - Simić, Katarina
AU  - Ljujić, Jovana
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5811
AB  - Chemotaxonomy presents various challenges that need to be overcome in order to obtain valid and reliable results. Individual genetic and environmental variations can give a false picture and lead to wrong conclusions. Applying a holistic approach, based on multivariate data analysis, these challenges can be overcome. Thus, a metabolomics approach has to be optimized depending on the subject of research. We used 1H NMR-based metabolomics as a potential chemotaxonomic tool on the selected Euphorbia species growing wild in Serbia. Principal components analysis (PCA), soft independent modeling by class analogy (SIMCA) and Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) were used to analyze obtained NMR data in order to reveal chemotaxonomic biomarkers. The standard protocol for plant metabolomics was optimized aiming to extract more specific metabolites, which are characteristic for the Euphorbia genus. The obtained models were validated, which revealed that variables unique for each species were associated with certain classes of molecules according to literature data. In E. salicifolia, acacetin-7-O-glycoside (not found before in the species) was detected, and the structure of the aglycone part was solved based on 2D NMR data. In the presented paper, we have shown that metabolomics can be successfully used in Euphorbia chemotaxonomy.
PB  - MDPI
T2  - Plants
T1  - Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia
VL  - 12
IS  - 2
SP  - 262
DO  - 10.3390/plants12020262
ER  - 

@article{
author = "Sofrenić, Ivana and Anđelković, Boban D. and Gođevac, Dejan and Ivanović, Stefan and Simić, Katarina and Ljujić, Jovana and Tešević, Vele and Milosavljević, Slobodan",
year = "2023",
abstract = "Chemotaxonomy presents various challenges that need to be overcome in order to obtain valid and reliable results. Individual genetic and environmental variations can give a false picture and lead to wrong conclusions. Applying a holistic approach, based on multivariate data analysis, these challenges can be overcome. Thus, a metabolomics approach has to be optimized depending on the subject of research. We used 1H NMR-based metabolomics as a potential chemotaxonomic tool on the selected Euphorbia species growing wild in Serbia. Principal components analysis (PCA), soft independent modeling by class analogy (SIMCA) and Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) were used to analyze obtained NMR data in order to reveal chemotaxonomic biomarkers. The standard protocol for plant metabolomics was optimized aiming to extract more specific metabolites, which are characteristic for the Euphorbia genus. The obtained models were validated, which revealed that variables unique for each species were associated with certain classes of molecules according to literature data. In E. salicifolia, acacetin-7-O-glycoside (not found before in the species) was detected, and the structure of the aglycone part was solved based on 2D NMR data. In the presented paper, we have shown that metabolomics can be successfully used in Euphorbia chemotaxonomy.",
publisher = "MDPI",
journal = "Plants",
title = "Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia",
volume = "12",
number = "2",
pages = "262",
doi = "10.3390/plants12020262"
}

Sofrenić, I., Anđelković, B. D., Gođevac, D., Ivanović, S., Simić, K., Ljujić, J., Tešević, V.,& Milosavljević, S.. (2023). Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia. in Plants
MDPI., 12(2), 262.
https://doi.org/10.3390/plants12020262

Sofrenić I, Anđelković BD, Gođevac D, Ivanović S, Simić K, Ljujić J, Tešević V, Milosavljević S. Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia. in Plants. 2023;12(2):262.
doi:10.3390/plants12020262 .

Sofrenić, Ivana, Anđelković, Boban D., Gođevac, Dejan, Ivanović, Stefan, Simić, Katarina, Ljujić, Jovana, Tešević, Vele, Milosavljević, Slobodan, "Metabolomics as a Potential Chemotaxonomical Tool: Application on the Selected Euphorbia Species Growing Wild in Serbia" in Plants, 12, no. 2 (2023):262,
https://doi.org/10.3390/plants12020262 . .

TY  - JOUR
AU  - Novaković, Miroslav
AU  - Ilić-Tomić, Tatjana
AU  - Đorđević, Iris
AU  - Anđelković, Boban
AU  - Tešević, Slobodan
AU  - Milosavljević, Slobodan
AU  - Asakawa, Yoshinori
PY  - 2023
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6259
AB  - Bisbibenzyls are specialized metabolites found exclusively in liverworts, until recently; they represent chemical markers of liverworts. Their occurrence in vascular plants was noticed in 2007, when they were found in Primula veris subsp. macrocalyx from Russia. This report prompted us to chemically analyze the two most common Serbian Primula species, P. veris subsp. columnae and P. acaulis, in order to determine the presence of bisbibenzyls in them. Our study revealed nine structurally distinct bisbibenzyls (1–9), identified based on 1D and 2D NMR, IR, UV and HRESIMS data. Among them were five previously undescribed compounds (2–6). The remaining com­ pounds found and previously described in the literature were: the bisbibenzyls riccardin C (1), isoperrottetin A (7), isoplagiochin E (8) and 11-O-demethylmarchantin I (9), as well as 4-hydroxyphenylmethylketone (10) and 4-hydroxy-3-methoxyphenylmethylketone (11). Riccardin C was the most dominant bisbibenzyl in both species studied. Previously, it was the first bisbibenzyl found in vascular plants (P. veris subsp. macrocalyx). An assessment of the cytotoxic activity of the isolated compounds against A549 lung cancer and healthy MRC5 cell lines was also the subject of our study. Compounds 6 and 9 exhibited significant cytotoxic activity expressed by IC50 values of 12 μM, but the selectivity was not satisfactory.
PB  - Elsevier
T2  - Phytochemistry
T1  - Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L
VL  - 212
EP  - 113719
DO  - 10.1016/j.phytochem.2023.113719
ER  - 

@article{
author = "Novaković, Miroslav and Ilić-Tomić, Tatjana and Đorđević, Iris and Anđelković, Boban and Tešević, Slobodan and Milosavljević, Slobodan and Asakawa, Yoshinori",
year = "2023, 2023",
abstract = "Bisbibenzyls are specialized metabolites found exclusively in liverworts, until recently; they represent chemical markers of liverworts. Their occurrence in vascular plants was noticed in 2007, when they were found in Primula veris subsp. macrocalyx from Russia. This report prompted us to chemically analyze the two most common Serbian Primula species, P. veris subsp. columnae and P. acaulis, in order to determine the presence of bisbibenzyls in them. Our study revealed nine structurally distinct bisbibenzyls (1–9), identified based on 1D and 2D NMR, IR, UV and HRESIMS data. Among them were five previously undescribed compounds (2–6). The remaining com­ pounds found and previously described in the literature were: the bisbibenzyls riccardin C (1), isoperrottetin A (7), isoplagiochin E (8) and 11-O-demethylmarchantin I (9), as well as 4-hydroxyphenylmethylketone (10) and 4-hydroxy-3-methoxyphenylmethylketone (11). Riccardin C was the most dominant bisbibenzyl in both species studied. Previously, it was the first bisbibenzyl found in vascular plants (P. veris subsp. macrocalyx). An assessment of the cytotoxic activity of the isolated compounds against A549 lung cancer and healthy MRC5 cell lines was also the subject of our study. Compounds 6 and 9 exhibited significant cytotoxic activity expressed by IC50 values of 12 μM, but the selectivity was not satisfactory.",
publisher = "Elsevier",
journal = "Phytochemistry",
title = "Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L",
volume = "212",
pages = "113719",
doi = "10.1016/j.phytochem.2023.113719"
}

Novaković, M., Ilić-Tomić, T., Đorđević, I., Anđelković, B., Tešević, S., Milosavljević, S.,& Asakawa, Y.. (2023). Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L. in Phytochemistry
Elsevier., 212.
https://doi.org/10.1016/j.phytochem.2023.113719

Novaković M, Ilić-Tomić T, Đorđević I, Anđelković B, Tešević S, Milosavljević S, Asakawa Y. Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L. in Phytochemistry. 2023;212:null-113719.
doi:10.1016/j.phytochem.2023.113719 .

Novaković, Miroslav, Ilić-Tomić, Tatjana, Đorđević, Iris, Anđelković, Boban, Tešević, Slobodan, Milosavljević, Slobodan, Asakawa, Yoshinori, "Bisbibenzyls from Serbian Primula veris subsp. Columnae (Ten.) Lȕdi and P. acaulis (L.) L" in Phytochemistry, 212 (2023),
https://doi.org/10.1016/j.phytochem.2023.113719 . .

TY  - JOUR
AU  - Madžgalj, Valerija
AU  - Petrović, Aleksandar
AU  - Čakar, Uroš
AU  - Maraš, Vesna
AU  - Sofrenić, Ivana
AU  - Tešević, Vele
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5818
AB  - This study aimed to show aromatic profile of wines produced from two autochthonous grape cultivars Krstač (K) and Žižak (Z). During the wine production two enzymatic preparations (EP) Lallzyme cuvee blanc (CB) and Lallzyme enzymatic preparation β (EB) and different time of skin contact (4 and 8 h) were applied. Aromatic compounds were detected by GC/FID–MS ana­lysis. Significantly higher content of total detected aromatic compounds com­pared to appropriate controls (168.54 and 161.72 mg L-1) was observed for K EB4h (176.33 mg L-1) and Z CB4h (177.29 mg L-1) wines. Skin contact and usage of EP mostly increased content of 2-phenylethyl and isoamyl alcohols. Wines from both varieties showed higher content of hexanoic and octanoic acids compared to the control. It is interesting to emphasize that content of esters that are responsible for fruity aroma of wine which is important for plea­sant taste (isoamyl acetate – banana, ethyl hexanoate – ripe banana, 2-phe­nyl­ethyl acetate – powerful fruity rose like) were increased in all samples com­pared to the controls. The highest grades, after sensory evaluation, were obtained for K EB 8h (18.0 out of 20.0) and Z CB 8h (18.2 out of 20.0).
PB  - Belgrade : Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - The influence of different enzymatic preparations and skin contact time on aromatic profile of wines produced from autochthonous grape varieties Krstač and Žižak: Scientific paper
VL  - 88
IS  - 1
SP  - 11
EP  - 23
EP  - 
DO  - 10.2298/JSC220311056M
ER  - 

@article{
author = "Madžgalj, Valerija and Petrović, Aleksandar and Čakar, Uroš and Maraš, Vesna and Sofrenić, Ivana and Tešević, Vele",
year = "2023",
abstract = "This study aimed to show aromatic profile of wines produced from two autochthonous grape cultivars Krstač (K) and Žižak (Z). During the wine production two enzymatic preparations (EP) Lallzyme cuvee blanc (CB) and Lallzyme enzymatic preparation β (EB) and different time of skin contact (4 and 8 h) were applied. Aromatic compounds were detected by GC/FID–MS ana­lysis. Significantly higher content of total detected aromatic compounds com­pared to appropriate controls (168.54 and 161.72 mg L-1) was observed for K EB4h (176.33 mg L-1) and Z CB4h (177.29 mg L-1) wines. Skin contact and usage of EP mostly increased content of 2-phenylethyl and isoamyl alcohols. Wines from both varieties showed higher content of hexanoic and octanoic acids compared to the control. It is interesting to emphasize that content of esters that are responsible for fruity aroma of wine which is important for plea­sant taste (isoamyl acetate – banana, ethyl hexanoate – ripe banana, 2-phe­nyl­ethyl acetate – powerful fruity rose like) were increased in all samples com­pared to the controls. The highest grades, after sensory evaluation, were obtained for K EB 8h (18.0 out of 20.0) and Z CB 8h (18.2 out of 20.0).",
publisher = "Belgrade : Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "The influence of different enzymatic preparations and skin contact time on aromatic profile of wines produced from autochthonous grape varieties Krstač and Žižak: Scientific paper",
volume = "88",
number = "1",
pages = "11-23-",
doi = "10.2298/JSC220311056M"
}

Madžgalj, V., Petrović, A., Čakar, U., Maraš, V., Sofrenić, I.,& Tešević, V.. (2023). The influence of different enzymatic preparations and skin contact time on aromatic profile of wines produced from autochthonous grape varieties Krstač and Žižak: Scientific paper. in Journal of the Serbian Chemical Society
Belgrade : Serbian Chemical Society., 88(1), 11-23.
https://doi.org/10.2298/JSC220311056M

Madžgalj V, Petrović A, Čakar U, Maraš V, Sofrenić I, Tešević V. The influence of different enzymatic preparations and skin contact time on aromatic profile of wines produced from autochthonous grape varieties Krstač and Žižak: Scientific paper. in Journal of the Serbian Chemical Society. 2023;88(1):11-23.
doi:10.2298/JSC220311056M .

Madžgalj, Valerija, Petrović, Aleksandar, Čakar, Uroš, Maraš, Vesna, Sofrenić, Ivana, Tešević, Vele, "The influence of different enzymatic preparations and skin contact time on aromatic profile of wines produced from autochthonous grape varieties Krstač and Žižak: Scientific paper" in Journal of the Serbian Chemical Society, 88, no. 1 (2023):11-23,
https://doi.org/10.2298/JSC220311056M . .

TY  - JOUR
AU  - Smiljanić, Katarina
AU  - Prodić, Ivana
AU  - Trifunović, Sara
AU  - Krstić-Ristivojević, Maja
AU  - Aćimović, Milica G.
AU  - Stanković Jeremić, Jovana
AU  - Lončar, Biljana
AU  - Tešević, Vele
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6203
AB  - As byproducts of essential oil distillation, hydrolates are used in natural cosmetics/biomedicine due to their beneficial skin effects. However, data on their safety with relevant biological targets, such as human skin cells, are scarce. Therefore, we have tested nine hydrolates from the Lamiaceae family with skin fibroblasts that are responsible for extracellular collagenous matrix builds. Thyme, oregano, and winter savoury hydrolates showed several times higher total phenolics, which correlated strongly with their radical scavenging and antioxidative capacity; there was no correlation between their viability profiles and the reducing sugar levels. No proteins/peptides were detected. All hydrolates appeared safe for prolonged skin exposure except for 10-fold diluted lavender, which showed cytotoxicity (~20%), as well as rosemary and lavandin (~10%) using viability, DNA synthesis, and cell count testing. Clary sage, oregano, lemon balm, and thyme hydrolates (10-fold diluted) increased fibroblast viability and/or proliferation by 10–30% compared with the control, while their viability remained unaffected by Mentha and winter savoury. In line with the STITCH database, increased viability could be attributed to thymol presence in oregano and thyme hydrolates in lemon balm, which is most likely attributable to neral and geranial. The proliferative effect of clary sage could be supported by alpha-terpineol, not linalool. The major volatile organic compounds (VOCs) associated with cytotoxic effects on fibroblasts were borneol, 1,8-cineole, and terpinene-4-ol. Further research with pure compounds is warranted to confirm the roles of VOCs in the observed effects that are relevant to cosmetic and wound healing aspects.
PB  - MDPI
T2  - Antioxidants
T1  - Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts
VL  - 12
IS  - 11
DO  - 10.3390/antiox12111988
ER  - 

@article{
author = "Smiljanić, Katarina and Prodić, Ivana and Trifunović, Sara and Krstić-Ristivojević, Maja and Aćimović, Milica G. and Stanković Jeremić, Jovana and Lončar, Biljana and Tešević, Vele",
year = "2023",
abstract = "As byproducts of essential oil distillation, hydrolates are used in natural cosmetics/biomedicine due to their beneficial skin effects. However, data on their safety with relevant biological targets, such as human skin cells, are scarce. Therefore, we have tested nine hydrolates from the Lamiaceae family with skin fibroblasts that are responsible for extracellular collagenous matrix builds. Thyme, oregano, and winter savoury hydrolates showed several times higher total phenolics, which correlated strongly with their radical scavenging and antioxidative capacity; there was no correlation between their viability profiles and the reducing sugar levels. No proteins/peptides were detected. All hydrolates appeared safe for prolonged skin exposure except for 10-fold diluted lavender, which showed cytotoxicity (~20%), as well as rosemary and lavandin (~10%) using viability, DNA synthesis, and cell count testing. Clary sage, oregano, lemon balm, and thyme hydrolates (10-fold diluted) increased fibroblast viability and/or proliferation by 10–30% compared with the control, while their viability remained unaffected by Mentha and winter savoury. In line with the STITCH database, increased viability could be attributed to thymol presence in oregano and thyme hydrolates in lemon balm, which is most likely attributable to neral and geranial. The proliferative effect of clary sage could be supported by alpha-terpineol, not linalool. The major volatile organic compounds (VOCs) associated with cytotoxic effects on fibroblasts were borneol, 1,8-cineole, and terpinene-4-ol. Further research with pure compounds is warranted to confirm the roles of VOCs in the observed effects that are relevant to cosmetic and wound healing aspects.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts",
volume = "12",
number = "11",
doi = "10.3390/antiox12111988"
}

Smiljanić, K., Prodić, I., Trifunović, S., Krstić-Ristivojević, M., Aćimović, M. G., Stanković Jeremić, J., Lončar, B.,& Tešević, V.. (2023). Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts. in Antioxidants
MDPI., 12(11).
https://doi.org/10.3390/antiox12111988

Smiljanić K, Prodić I, Trifunović S, Krstić-Ristivojević M, Aćimović MG, Stanković Jeremić J, Lončar B, Tešević V. Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts. in Antioxidants. 2023;12(11).
doi:10.3390/antiox12111988 .

Smiljanić, Katarina, Prodić, Ivana, Trifunović, Sara, Krstić-Ristivojević, Maja, Aćimović, Milica G., Stanković Jeremić, Jovana, Lončar, Biljana, Tešević, Vele, "Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts" in Antioxidants, 12, no. 11 (2023),
https://doi.org/10.3390/antiox12111988 . .

TY  - THES
AU  - Paunović, Jelena
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6082
AB  - Predmet proučavanja ovog završnog rada je medicinska gljiva Ganoderma resinaceum poznata kao smolasta sjajnica. Osnovni cilj ovog završnog rada je bio izolovanje bioaktivnog jedinjenja triterpenskog tipa i određivanje strukture primenom 1D i 2D NMR spektroskopije.
U okviru ovog završnog rada je izolovano i okarakterisano jedinjenje triterpenskog tipa, ganoderiol B, koje je prvi put izolovano iz plodonosnih tela Ganoderma resinaceum.
T1  - Izolovanje i određivanje strukture triterpenskog alkohola iz medicinske gljive Ganoderma resinaceum
SP  - 1
EP  - 30
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6082
ER  - 

@misc{
author = "Paunović, Jelena",
year = "2023",
abstract = "Predmet proučavanja ovog završnog rada je medicinska gljiva Ganoderma resinaceum poznata kao smolasta sjajnica. Osnovni cilj ovog završnog rada je bio izolovanje bioaktivnog jedinjenja triterpenskog tipa i određivanje strukture primenom 1D i 2D NMR spektroskopije.
U okviru ovog završnog rada je izolovano i okarakterisano jedinjenje triterpenskog tipa, ganoderiol B, koje je prvi put izolovano iz plodonosnih tela Ganoderma resinaceum.",
title = "Izolovanje i određivanje strukture triterpenskog alkohola iz medicinske gljive Ganoderma resinaceum",
pages = "1-30",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6082"
}

Paunović, J.. (2023). Izolovanje i određivanje strukture triterpenskog alkohola iz medicinske gljive Ganoderma resinaceum. , 1-30.
https://hdl.handle.net/21.15107/rcub_cherry_6082

Paunović J. Izolovanje i određivanje strukture triterpenskog alkohola iz medicinske gljive Ganoderma resinaceum. 2023;:1-30.
https://hdl.handle.net/21.15107/rcub_cherry_6082 .

Paunović, Jelena, "Izolovanje i određivanje strukture triterpenskog alkohola iz medicinske gljive Ganoderma resinaceum" (2023):1-30,
https://hdl.handle.net/21.15107/rcub_cherry_6082 .

TY  - THES
AU  - Jovković, Marija
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6134
AB  - C. coggygria, ruj ili “dimno drvo” je jedna od najpoznatijih vrsta biljnog roda Cotinus koja 
pripada velikoj familiji Anacardiaceae. Zbog raznovrsnosti metabolita koju ova biljna vrsta 
sintetiše i njihove biološke aktivnosti, česta je njena upotreba u tradicionalnoj medicini. Između 
ostalih, ističu se antiinflamatorna, antimikrobna i antikancerogena svojstva. Cilj ovog istraživanja 
bio je izolovanje i karakterizacija flavonoida iz biljne vrste C. coggygria. Primenom klasičnih i 
instrumentalnih hromatografskih metoda iz ekstrakata srži stabla ruja, izolovano je sedam 
jedinjenja: sulfuretin, fustin, fisetin, taksifolin, butin, butein i jedno novo jedinjenje 2,7,3’,4’-
tetrahidroksiflavanon. Struktura ovih jedinjenja određena je primenom 1D i 2D NMR 
spektroskopkih metoda.
T1  - Izolovanje i određivanje strukture flavonoida iz biljne  vrste Cotinus coggygria
SP  - 1
EP  - 63
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6134
ER  - 

@mastersthesis{
author = "Jovković, Marija",
year = "2023",
abstract = "C. coggygria, ruj ili “dimno drvo” je jedna od najpoznatijih vrsta biljnog roda Cotinus koja 
pripada velikoj familiji Anacardiaceae. Zbog raznovrsnosti metabolita koju ova biljna vrsta 
sintetiše i njihove biološke aktivnosti, česta je njena upotreba u tradicionalnoj medicini. Između 
ostalih, ističu se antiinflamatorna, antimikrobna i antikancerogena svojstva. Cilj ovog istraživanja 
bio je izolovanje i karakterizacija flavonoida iz biljne vrste C. coggygria. Primenom klasičnih i 
instrumentalnih hromatografskih metoda iz ekstrakata srži stabla ruja, izolovano je sedam 
jedinjenja: sulfuretin, fustin, fisetin, taksifolin, butin, butein i jedno novo jedinjenje 2,7,3’,4’-
tetrahidroksiflavanon. Struktura ovih jedinjenja određena je primenom 1D i 2D NMR 
spektroskopkih metoda.",
title = "Izolovanje i određivanje strukture flavonoida iz biljne  vrste Cotinus coggygria",
pages = "1-63",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6134"
}

Jovković, M.. (2023). Izolovanje i određivanje strukture flavonoida iz biljne  vrste Cotinus coggygria. , 1-63.
https://hdl.handle.net/21.15107/rcub_cherry_6134

Jovković M. Izolovanje i određivanje strukture flavonoida iz biljne  vrste Cotinus coggygria. 2023;:1-63.
https://hdl.handle.net/21.15107/rcub_cherry_6134 .

Jovković, Marija, "Izolovanje i određivanje strukture flavonoida iz biljne  vrste Cotinus coggygria" (2023):1-63,
https://hdl.handle.net/21.15107/rcub_cherry_6134 .

TY  - JOUR
AU  - Veljović, Katarina
AU  - Tešević, Vele
AU  - Mitrović, Hristina
AU  - Stanković, Marija
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6190
AB  - IntroductionOregano essential oil (OEO) is one of the most widely used essential oils worldwide due to its huge therapeutic benefits. Nevertheless, data on the effects of the endemic species Origanum minutiflorum, also known as wild or Turkish oregano, is scarce. On the other hand, various chronic lung diseases, characterised by persistent inflammation, oxidative stress, and common bacterial infections, do not have effective pharmacological therapy. Hence, the aim of this study is to examine the effects of wild oregano essential oil (WOEO) on human bronchial epithelial cells and lung pathogens.MethodsWe provided a detailed chemical composition of WOEO using GC-MS and GC-FID analysis. Anti-inflammatory effects of WOEO were analysed using the qRT-PCR and ELISA methods, while antioxidative properties were examined by using the dichlorofluorescein assay in BEAS-2B cells. Antibacterial activity was tested on lung pathogens by using the agar diffusion assay.ResultsThe major constituents of WOEO, analysed in this study, were carvacrol, linalool, p-cymene, γ-terpinene, and (E)-caryophyllene. We found that treatment with WOEO attenuated LPS-induced IL8 gene expression and hydrogen peroxide-induced oxidative stress in BEAS-2B cells. Moreover, WOEO showed an inhibitory effect on pathogenic bacteria Acinetobacter baumannii and highly resistant Klebsiella pneumoniae commonly seen in healthcare-associated pneumonia.ConclusionOur work presents new insights into the anti-inflammatory, antioxidative, and antimicrobial properties of WOEO which may be used as a simple and local treatment in various chronic lung diseases.
PB  - Elsevier
T2  - Journal of Herbal Medicine
T1  - Essential oil of Origanum minutiflorum exhibits anti-inflammatory and antioxidative effects in human bronchial cells and antimicrobial activity on lung pathogens
VL  - 39
SP  - 100651
DO  - 10.1016/j.hermed.2023.100651
ER  - 

@article{
author = "Veljović, Katarina and Tešević, Vele and Mitrović, Hristina and Stanković, Marija",
year = "2023",
abstract = "IntroductionOregano essential oil (OEO) is one of the most widely used essential oils worldwide due to its huge therapeutic benefits. Nevertheless, data on the effects of the endemic species Origanum minutiflorum, also known as wild or Turkish oregano, is scarce. On the other hand, various chronic lung diseases, characterised by persistent inflammation, oxidative stress, and common bacterial infections, do not have effective pharmacological therapy. Hence, the aim of this study is to examine the effects of wild oregano essential oil (WOEO) on human bronchial epithelial cells and lung pathogens.MethodsWe provided a detailed chemical composition of WOEO using GC-MS and GC-FID analysis. Anti-inflammatory effects of WOEO were analysed using the qRT-PCR and ELISA methods, while antioxidative properties were examined by using the dichlorofluorescein assay in BEAS-2B cells. Antibacterial activity was tested on lung pathogens by using the agar diffusion assay.ResultsThe major constituents of WOEO, analysed in this study, were carvacrol, linalool, p-cymene, γ-terpinene, and (E)-caryophyllene. We found that treatment with WOEO attenuated LPS-induced IL8 gene expression and hydrogen peroxide-induced oxidative stress in BEAS-2B cells. Moreover, WOEO showed an inhibitory effect on pathogenic bacteria Acinetobacter baumannii and highly resistant Klebsiella pneumoniae commonly seen in healthcare-associated pneumonia.ConclusionOur work presents new insights into the anti-inflammatory, antioxidative, and antimicrobial properties of WOEO which may be used as a simple and local treatment in various chronic lung diseases.",
publisher = "Elsevier",
journal = "Journal of Herbal Medicine",
title = "Essential oil of Origanum minutiflorum exhibits anti-inflammatory and antioxidative effects in human bronchial cells and antimicrobial activity on lung pathogens",
volume = "39",
pages = "100651",
doi = "10.1016/j.hermed.2023.100651"
}

Veljović, K., Tešević, V., Mitrović, H.,& Stanković, M.. (2023). Essential oil of Origanum minutiflorum exhibits anti-inflammatory and antioxidative effects in human bronchial cells and antimicrobial activity on lung pathogens. in Journal of Herbal Medicine
Elsevier., 39, 100651.
https://doi.org/10.1016/j.hermed.2023.100651

Veljović K, Tešević V, Mitrović H, Stanković M. Essential oil of Origanum minutiflorum exhibits anti-inflammatory and antioxidative effects in human bronchial cells and antimicrobial activity on lung pathogens. in Journal of Herbal Medicine. 2023;39:100651.
doi:10.1016/j.hermed.2023.100651 .

Veljović, Katarina, Tešević, Vele, Mitrović, Hristina, Stanković, Marija, "Essential oil of Origanum minutiflorum exhibits anti-inflammatory and antioxidative effects in human bronchial cells and antimicrobial activity on lung pathogens" in Journal of Herbal Medicine, 39 (2023):100651,
https://doi.org/10.1016/j.hermed.2023.100651 . .

TY  - JOUR
AU  - Gospodinova, Z.
AU  - Antov, G.
AU  - Novaković, M.
AU  - Tešević, Vele
AU  - Krasteva, N.
AU  - Pavlov, D.
AU  - Valcheva-Kuzmanova, S.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6218
AB  - AbstractBackground and objectiveCotinus coggygria Scop. is a valuable medicinal plant species with pronounced pharmacological potential due to its numerous biological activities. The herb is characterized by a high content of polyphenols among which is fustin. The anticancer activities of fustin, however, are extremely weakly studied. The aim of the present study was to investigate the in vitro antiproliferative potential of fustin isolated from the heartwood of C. coggygria against cell lines originating from two of the most common cancer types – breast (MDA-MB-231 and MCF7), and colon cancer (Colon 26).Materials and methodsCell growth inhibitory properties of fustin were examined by MTT assay. Subsequently, phase-contrast and fluorescence microscopy analysis as well as colonyforming assay were carried out on the most sensitive to the cytostatic action of the fustin cell line.ResultsThe obtained results showed that fustin reduced the proliferation of all studied cell lines. The highest cytostatic effect was registered towards breast cancer MDA-MB-231 cells with a half maximal inhibitory concentration (IC50) value of 56.02 μg/ml followed by colon cancer cells with an IC50 of 78.07 μg/ml. MCF7 cell proliferation was least affected with a calculated IC50 of 187.8 μg/ml. Further investigations on breast cancer MDA-MB-231 cells indicated decreased density of cell
PB  - Sciendo
T2  - Acta Medica Bulgarica
T1  - Antiproliferative Activity of Natural Flavonoid Fustin Isolated from the Heartwood of Scop. Against Breast and Colon Cancer Cell Lines
VL  - 50
IS  - 1
SP  - 27
EP  - 33
DO  - 10.2478/amb-2023-0004
ER  - 

@article{
author = "Gospodinova, Z. and Antov, G. and Novaković, M. and Tešević, Vele and Krasteva, N. and Pavlov, D. and Valcheva-Kuzmanova, S.",
year = "2023",
abstract = "AbstractBackground and objectiveCotinus coggygria Scop. is a valuable medicinal plant species with pronounced pharmacological potential due to its numerous biological activities. The herb is characterized by a high content of polyphenols among which is fustin. The anticancer activities of fustin, however, are extremely weakly studied. The aim of the present study was to investigate the in vitro antiproliferative potential of fustin isolated from the heartwood of C. coggygria against cell lines originating from two of the most common cancer types – breast (MDA-MB-231 and MCF7), and colon cancer (Colon 26).Materials and methodsCell growth inhibitory properties of fustin were examined by MTT assay. Subsequently, phase-contrast and fluorescence microscopy analysis as well as colonyforming assay were carried out on the most sensitive to the cytostatic action of the fustin cell line.ResultsThe obtained results showed that fustin reduced the proliferation of all studied cell lines. The highest cytostatic effect was registered towards breast cancer MDA-MB-231 cells with a half maximal inhibitory concentration (IC50) value of 56.02 μg/ml followed by colon cancer cells with an IC50 of 78.07 μg/ml. MCF7 cell proliferation was least affected with a calculated IC50 of 187.8 μg/ml. Further investigations on breast cancer MDA-MB-231 cells indicated decreased density of cell",
publisher = "Sciendo",
journal = "Acta Medica Bulgarica",
title = "Antiproliferative Activity of Natural Flavonoid Fustin Isolated from the Heartwood of Scop. Against Breast and Colon Cancer Cell Lines",
volume = "50",
number = "1",
pages = "27-33",
doi = "10.2478/amb-2023-0004"
}

Gospodinova, Z., Antov, G., Novaković, M., Tešević, V., Krasteva, N., Pavlov, D.,& Valcheva-Kuzmanova, S.. (2023). Antiproliferative Activity of Natural Flavonoid Fustin Isolated from the Heartwood of Scop. Against Breast and Colon Cancer Cell Lines. in Acta Medica Bulgarica
Sciendo., 50(1), 27-33.
https://doi.org/10.2478/amb-2023-0004

Gospodinova Z, Antov G, Novaković M, Tešević V, Krasteva N, Pavlov D, Valcheva-Kuzmanova S. Antiproliferative Activity of Natural Flavonoid Fustin Isolated from the Heartwood of Scop. Against Breast and Colon Cancer Cell Lines. in Acta Medica Bulgarica. 2023;50(1):27-33.
doi:10.2478/amb-2023-0004 .

Gospodinova, Z., Antov, G., Novaković, M., Tešević, Vele, Krasteva, N., Pavlov, D., Valcheva-Kuzmanova, S., "Antiproliferative Activity of Natural Flavonoid Fustin Isolated from the Heartwood of Scop. Against Breast and Colon Cancer Cell Lines" in Acta Medica Bulgarica, 50, no. 1 (2023):27-33,
https://doi.org/10.2478/amb-2023-0004 . .

TY  - THES
AU  - Ivanović, Ljubica
PY  - 2023
UR  - https://eteze.bg.ac.rs/application/showtheses?thesesId=9369
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:31816/bdef:Content/download
UR  - https://plus.cobiss.net/cobiss/sr/sr/bib/130986249
UR  - https://nardus.mpn.gov.rs/handle/123456789/21930
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6239
AB  - U okviru ove doktorske disertacije proučavan je nutritivni i fitonutritivni sadržaj blitve koja je gajena u uslovima različitih režima đubrenja i navodnjavanja, pri čemu su ispitivane i funkcionalne osobine blitve u cilju utvrđivanja njenog potencijala kao funkcionalne hrane.U početnoj fazi eksperimenta određene su nutritivne, antinutritivne i fitonutritivne komponente u blitvi, kao i uticaj primjenjenih agrotehničkih mjera na pomenute komponente. Korišćenjem standardnih metoda za proksimativnu analizu (AOAC metode) utvrđeno je da svježa blitva ima sledeći sastav: voda- 89%, ukupni šećeri- 4,9%, proteini- 2,5%, pepeo- 1,8% i lipidi-0,45%. Savremenim instrumentalnim tehnikama (spektrofotometrija, ICP OES, tečna hromatografija) su kvantifikovane druge nutritivne, antinutritivne i fitonutritivne komponente u blitvi. Nađeno je da su prosječne koncentracije vitamina C, ukupnog hlorofila, karotenoida u 100 g svježe blitve su redom: 26,9 mg, 47,13 mg, 9,85 mg. Blitva ima visok sadržaj makro- i mikroelemenata od kojih su najzastupljeniji sledeći: kalijum (372,49 mg), kalcijum (178,6 mg), mangan (8,35 mg) i gvožđe (1,46 mg) izraženo na 100 g svježe blitve. Analizom ukupnog polifenolnog i flavonoidnog sadržaja pokazano je da je blitva bogata ovim fitonutrijentima, nakon čega su identifikovane i kvantifikovane četiri flavonoidne komponente: viteksin-2"-O-ksilozid, viteksin-6″-O-malonil-2″-O-ksilozid, izoramnetin-3,7-O-diglukozid i viteksin-6″-O-acetil-2″-O-ksilozid. Strukture ovih jedinjenja su potvrđene 1D i 2D NMR spektroskopijom (1H NMR,13 C NMR, COSY, HSQC, HMBC). Osim toga, određen je sadržaj nitrata u blitvi, koji je bio u granicama dozvoljenih vrijednosti.Statističkom analizom uticaja različitih režima navodnjavanja i đubrenja nađeno je da je đubrenje uticalo na prinos, morfološke karakteristike, količinu proteina, sadržaj fosfora, sadržaj izoramnetin-3,7-O-diglukozida, sadržaj hlorofila i vitamina C. Povećanjem količine primjenjene prihrane povećali su se svi pomenuti prametri, osim sadržaj fosfora i sadržaj izoramnetin-3,7-O-diglukozida, koji su bili niži sa povećanjem nivoa đubrenja. Interakcija navodnjavanja i đubrenja je značajno uticala na sadržaj Na i Cu i sadržaj viteksin-2"-O-ksilozida. Navodnjavanje nije imalo značajnog efekta na testirane parametre, osim na sadržaj nitrata, gdje je povećanjem nivoa navodnjavanja sadržaj nitrata u blitvi opadao, dok je povećanjem đubrenja rastao njihov sadržaj.Poslednja faza eksperimenta je obuhvatila ispitivanje antioksidativne, antiproliferativne i antimikrobne aktivnosti ekstrakta blitve. Rezultati su pokazali antioksidativnu aktivnost vodenog ekstrakta blitve u vrijednosti IC50=3,79 mg/ml (mjereno DPPH testom) dok je metanolni ekstrakt imao prosječni antioksidativni kapacitet od 8,0 (mjereno DPPH testom) odnosno 8,57 μmola ekvivalenta trolox-a/g (mjereno ABTS testom). Analizom antiproliferativne aktivnosti ekstrakta blitve je utvrđeno da postoji inhibicija rasta malignih MCF-7 ćelija i to 70% ćelija je inhibirano nakon 48 h inkubacije. Ispitivani ekstrakti blitve nijesu pokazali antimikrobnu aktivnost.
AB  - In this doctoral dissertation, the nutritional and phytonutrient content of Swiss chard grown under different irrigation and fertilization regimes was studied, while the functional properties of Swiss chard were also examined in order to determine its potential as a functional food.In the initial phase of the experiment, nutritional, anti-nutritive and phyto-nutritive components in Swiss chard were determined, as well as the influence of applied agrotechnical measurments on all tested parameters was monitored. Using standard methods for proximate analysis (AOAC methods), it was determined that fresh chard has the following composition: water- 89%, total sugars- 4,9 %, proteins- 2,5 %, ash- 1,8 % and lipids- 0,45%. Using modern instrumental techniques (spectrophotometry, ICP OES, liquid chromatography) other nutritional and phytonutritive components in Swiss chard were quantified. It was found that the average concentrations of vitamin C, total chlorophyll, carotenoids in 100 g of fresh chard are: 26,9 mg, 47,13 mg and 9,85 mg, respectively. Swiss chard has a high content of macro- and microelements, of which the most abundant are the following: potassium (372,49 mg), calcium (178,6 mg), followed by manganese (8,35 mg) and iron (1,46 mg) expressed per 100 g of fresh Swiss chard. The analysis of the total polyphenolic and flavonoid content showed that Swiss chard is rich in these phytonutrients, after which four flavonoid components were identified and quantified: vitexin-2"-O-xyloside, vitexin-6"-O-malonyl-2"-O-xyloside, isorhamnetin-3,7-O-diglucoside and vitexin-6″-O-acetyl-2″-O-xyloside. The structures of these compounds were confirmed by 1D and 2D NMR spectroscopy (1H NMR,13 C NMR, COSY, HSQC, HMBC). In addition, the content of nitrates in Swiss chard was determined, which was within the limits of permitted values.A statistical analysis of the effect of different irrigation and fertilization regimes found that fertilization influenced the yield, morphological characteristics, amount of protein, as well as phosphorus, isorhamnetin-3,7-O-diglucoside, chlorophyll, and vitamin C content. With increasing the amount of fertilization, values for all parameters mentioned above increased, except phosphorus and isorhamnetin-3,7-O-diglucoside content, which were found to be lower with increasing fertilization level. The interaction of irrigation and fertilization significantly affected Na and Cu content, as well as the content of vitexin-2"-O-xyloside. Irrigation had no significant effect on the studied parameters, except for the nitrate content. While the increased level of irrigation led to decreased nitrate content in Swiss chard, with increasing fertilization their content increased.The last phase of the experiment included investigation of the antioxidant, antiproliferative and antimicrobial activity of Swiss chard extract. The results showed the antioxidant activity of the aqueous extract of Swiss chard with an IC50 value of 3,79 mg/ml (measured by the DPPH test), while the methanolic extract had an average antioxidant capacity of 8,0 (measured by the DPPH test), 8,57 μmol of trolox equivalents per gram (measured by ABTS test). Analysis of the antiproliferative activity of Swiss chard extract revealed that there is an inhibition of the growth of malignant MCF-7 cells and that 70% of the cells were inhibited after 48 hours of incubation. The studied Swiss chard extracts did not show antimicrobial activity.
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Nutritivna vrijednost i osnovne fitohemijske osobine blitve (Beta vulgaris ssp. cicla L. Voss) gajene u različitim uslovima navodnjavanja i prihranjivanja
UR  - https://hdl.handle.net/21.15107/rcub_nardus_21930
ER  - 

@phdthesis{
author = "Ivanović, Ljubica",
year = "2023",
abstract = "U okviru ove doktorske disertacije proučavan je nutritivni i fitonutritivni sadržaj blitve koja je gajena u uslovima različitih režima đubrenja i navodnjavanja, pri čemu su ispitivane i funkcionalne osobine blitve u cilju utvrđivanja njenog potencijala kao funkcionalne hrane.U početnoj fazi eksperimenta određene su nutritivne, antinutritivne i fitonutritivne komponente u blitvi, kao i uticaj primjenjenih agrotehničkih mjera na pomenute komponente. Korišćenjem standardnih metoda za proksimativnu analizu (AOAC metode) utvrđeno je da svježa blitva ima sledeći sastav: voda- 89%, ukupni šećeri- 4,9%, proteini- 2,5%, pepeo- 1,8% i lipidi-0,45%. Savremenim instrumentalnim tehnikama (spektrofotometrija, ICP OES, tečna hromatografija) su kvantifikovane druge nutritivne, antinutritivne i fitonutritivne komponente u blitvi. Nađeno je da su prosječne koncentracije vitamina C, ukupnog hlorofila, karotenoida u 100 g svježe blitve su redom: 26,9 mg, 47,13 mg, 9,85 mg. Blitva ima visok sadržaj makro- i mikroelemenata od kojih su najzastupljeniji sledeći: kalijum (372,49 mg), kalcijum (178,6 mg), mangan (8,35 mg) i gvožđe (1,46 mg) izraženo na 100 g svježe blitve. Analizom ukupnog polifenolnog i flavonoidnog sadržaja pokazano je da je blitva bogata ovim fitonutrijentima, nakon čega su identifikovane i kvantifikovane četiri flavonoidne komponente: viteksin-2"-O-ksilozid, viteksin-6″-O-malonil-2″-O-ksilozid, izoramnetin-3,7-O-diglukozid i viteksin-6″-O-acetil-2″-O-ksilozid. Strukture ovih jedinjenja su potvrđene 1D i 2D NMR spektroskopijom (1H NMR,13 C NMR, COSY, HSQC, HMBC). Osim toga, određen je sadržaj nitrata u blitvi, koji je bio u granicama dozvoljenih vrijednosti.Statističkom analizom uticaja različitih režima navodnjavanja i đubrenja nađeno je da je đubrenje uticalo na prinos, morfološke karakteristike, količinu proteina, sadržaj fosfora, sadržaj izoramnetin-3,7-O-diglukozida, sadržaj hlorofila i vitamina C. Povećanjem količine primjenjene prihrane povećali su se svi pomenuti prametri, osim sadržaj fosfora i sadržaj izoramnetin-3,7-O-diglukozida, koji su bili niži sa povećanjem nivoa đubrenja. Interakcija navodnjavanja i đubrenja je značajno uticala na sadržaj Na i Cu i sadržaj viteksin-2"-O-ksilozida. Navodnjavanje nije imalo značajnog efekta na testirane parametre, osim na sadržaj nitrata, gdje je povećanjem nivoa navodnjavanja sadržaj nitrata u blitvi opadao, dok je povećanjem đubrenja rastao njihov sadržaj.Poslednja faza eksperimenta je obuhvatila ispitivanje antioksidativne, antiproliferativne i antimikrobne aktivnosti ekstrakta blitve. Rezultati su pokazali antioksidativnu aktivnost vodenog ekstrakta blitve u vrijednosti IC50=3,79 mg/ml (mjereno DPPH testom) dok je metanolni ekstrakt imao prosječni antioksidativni kapacitet od 8,0 (mjereno DPPH testom) odnosno 8,57 μmola ekvivalenta trolox-a/g (mjereno ABTS testom). Analizom antiproliferativne aktivnosti ekstrakta blitve je utvrđeno da postoji inhibicija rasta malignih MCF-7 ćelija i to 70% ćelija je inhibirano nakon 48 h inkubacije. Ispitivani ekstrakti blitve nijesu pokazali antimikrobnu aktivnost., In this doctoral dissertation, the nutritional and phytonutrient content of Swiss chard grown under different irrigation and fertilization regimes was studied, while the functional properties of Swiss chard were also examined in order to determine its potential as a functional food.In the initial phase of the experiment, nutritional, anti-nutritive and phyto-nutritive components in Swiss chard were determined, as well as the influence of applied agrotechnical measurments on all tested parameters was monitored. Using standard methods for proximate analysis (AOAC methods), it was determined that fresh chard has the following composition: water- 89%, total sugars- 4,9 %, proteins- 2,5 %, ash- 1,8 % and lipids- 0,45%. Using modern instrumental techniques (spectrophotometry, ICP OES, liquid chromatography) other nutritional and phytonutritive components in Swiss chard were quantified. It was found that the average concentrations of vitamin C, total chlorophyll, carotenoids in 100 g of fresh chard are: 26,9 mg, 47,13 mg and 9,85 mg, respectively. Swiss chard has a high content of macro- and microelements, of which the most abundant are the following: potassium (372,49 mg), calcium (178,6 mg), followed by manganese (8,35 mg) and iron (1,46 mg) expressed per 100 g of fresh Swiss chard. The analysis of the total polyphenolic and flavonoid content showed that Swiss chard is rich in these phytonutrients, after which four flavonoid components were identified and quantified: vitexin-2"-O-xyloside, vitexin-6"-O-malonyl-2"-O-xyloside, isorhamnetin-3,7-O-diglucoside and vitexin-6″-O-acetyl-2″-O-xyloside. The structures of these compounds were confirmed by 1D and 2D NMR spectroscopy (1H NMR,13 C NMR, COSY, HSQC, HMBC). In addition, the content of nitrates in Swiss chard was determined, which was within the limits of permitted values.A statistical analysis of the effect of different irrigation and fertilization regimes found that fertilization influenced the yield, morphological characteristics, amount of protein, as well as phosphorus, isorhamnetin-3,7-O-diglucoside, chlorophyll, and vitamin C content. With increasing the amount of fertilization, values for all parameters mentioned above increased, except phosphorus and isorhamnetin-3,7-O-diglucoside content, which were found to be lower with increasing fertilization level. The interaction of irrigation and fertilization significantly affected Na and Cu content, as well as the content of vitexin-2"-O-xyloside. Irrigation had no significant effect on the studied parameters, except for the nitrate content. While the increased level of irrigation led to decreased nitrate content in Swiss chard, with increasing fertilization their content increased.The last phase of the experiment included investigation of the antioxidant, antiproliferative and antimicrobial activity of Swiss chard extract. The results showed the antioxidant activity of the aqueous extract of Swiss chard with an IC50 value of 3,79 mg/ml (measured by the DPPH test), while the methanolic extract had an average antioxidant capacity of 8,0 (measured by the DPPH test), 8,57 μmol of trolox equivalents per gram (measured by ABTS test). Analysis of the antiproliferative activity of Swiss chard extract revealed that there is an inhibition of the growth of malignant MCF-7 cells and that 70% of the cells were inhibited after 48 hours of incubation. The studied Swiss chard extracts did not show antimicrobial activity.",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Nutritivna vrijednost i osnovne fitohemijske osobine blitve (Beta vulgaris ssp. cicla L. Voss) gajene u različitim uslovima navodnjavanja i prihranjivanja",
url = "https://hdl.handle.net/21.15107/rcub_nardus_21930"
}

Ivanović, L.. (2023). Nutritivna vrijednost i osnovne fitohemijske osobine blitve (Beta vulgaris ssp. cicla L. Voss) gajene u različitim uslovima navodnjavanja i prihranjivanja. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_21930

Ivanović L. Nutritivna vrijednost i osnovne fitohemijske osobine blitve (Beta vulgaris ssp. cicla L. Voss) gajene u različitim uslovima navodnjavanja i prihranjivanja. in Универзитет у Београду. 2023;.
https://hdl.handle.net/21.15107/rcub_nardus_21930 .

Ivanović, Ljubica, "Nutritivna vrijednost i osnovne fitohemijske osobine blitve (Beta vulgaris ssp. cicla L. Voss) gajene u različitim uslovima navodnjavanja i prihranjivanja" in Универзитет у Београду (2023),
https://hdl.handle.net/21.15107/rcub_nardus_21930 .

TY  - JOUR
AU  - Popović, Branko
AU  - Mitrović, Olga
AU  - Nikićević, Ninoslav
AU  - Tešević, Vele
AU  - Urošević, Ivan
AU  - Miletić, Nemanja
AU  - Milojević, Svetomir
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6249
AB  - The aim of this study was to compare the aromatic profile of plum spirits, obtained from the Požegača and Stanley varieties, as affected by different combinations of pre-distillation steps used in traditional and six modified production methods that are common in Serbian distilleries. Traditional plum spirits (produced from spontaneously fermented mashes of crushed plums with stones distilled after two months of storage) had the highest contents of ethyl acetate, benzaldehyde, and total acids, which resulted in the occurrence of an unpleasant solvent-like and stone-like odour and acidic taste. These sensory defects were overcome by the distillation of fermented mashes immediately after the completion of alcoholic fermentation. Depending on the combination of the pre-distillation steps, plum spirits from mashes distilled immediately after alcoholic fermentation were characterized by different aromatic profiles: closer to traditional (from spontaneously fermented crushed plums with/without stones) or with a more pronounced fruity character (from pulped plums without stones regardless of the way of fermentation). These differences in aroma profiles have arisen mostly because of the significantly different contents and OAVs of ethyl esters and volatile fatty acids. The appropriate combination of the pre-distillation steps, which is adapted to the variety, can significantly improve the quality of the plum spirit compared to the traditionally produced spirit.
PB  - MDPI
T2  - Processes
T1  - Influence of Different Pre-Distillation Steps on Aromatic Profile of Plum Spirits Produced by Traditional and Modified Methods
VL  - 11
IS  - 3
SP  - 863
DO  - 10.3390/pr11030863
ER  - 

@article{
author = "Popović, Branko and Mitrović, Olga and Nikićević, Ninoslav and Tešević, Vele and Urošević, Ivan and Miletić, Nemanja and Milojević, Svetomir",
year = "2023",
abstract = "The aim of this study was to compare the aromatic profile of plum spirits, obtained from the Požegača and Stanley varieties, as affected by different combinations of pre-distillation steps used in traditional and six modified production methods that are common in Serbian distilleries. Traditional plum spirits (produced from spontaneously fermented mashes of crushed plums with stones distilled after two months of storage) had the highest contents of ethyl acetate, benzaldehyde, and total acids, which resulted in the occurrence of an unpleasant solvent-like and stone-like odour and acidic taste. These sensory defects were overcome by the distillation of fermented mashes immediately after the completion of alcoholic fermentation. Depending on the combination of the pre-distillation steps, plum spirits from mashes distilled immediately after alcoholic fermentation were characterized by different aromatic profiles: closer to traditional (from spontaneously fermented crushed plums with/without stones) or with a more pronounced fruity character (from pulped plums without stones regardless of the way of fermentation). These differences in aroma profiles have arisen mostly because of the significantly different contents and OAVs of ethyl esters and volatile fatty acids. The appropriate combination of the pre-distillation steps, which is adapted to the variety, can significantly improve the quality of the plum spirit compared to the traditionally produced spirit.",
publisher = "MDPI",
journal = "Processes",
title = "Influence of Different Pre-Distillation Steps on Aromatic Profile of Plum Spirits Produced by Traditional and Modified Methods",
volume = "11",
number = "3",
pages = "863",
doi = "10.3390/pr11030863"
}

Popović, B., Mitrović, O., Nikićević, N., Tešević, V., Urošević, I., Miletić, N.,& Milojević, S.. (2023). Influence of Different Pre-Distillation Steps on Aromatic Profile of Plum Spirits Produced by Traditional and Modified Methods. in Processes
MDPI., 11(3), 863.
https://doi.org/10.3390/pr11030863

Popović B, Mitrović O, Nikićević N, Tešević V, Urošević I, Miletić N, Milojević S. Influence of Different Pre-Distillation Steps on Aromatic Profile of Plum Spirits Produced by Traditional and Modified Methods. in Processes. 2023;11(3):863.
doi:10.3390/pr11030863 .

Popović, Branko, Mitrović, Olga, Nikićević, Ninoslav, Tešević, Vele, Urošević, Ivan, Miletić, Nemanja, Milojević, Svetomir, "Influence of Different Pre-Distillation Steps on Aromatic Profile of Plum Spirits Produced by Traditional and Modified Methods" in Processes, 11, no. 3 (2023):863,
https://doi.org/10.3390/pr11030863 . .

TY  - THES
AU  - Vulićević, Biljana
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5776
AB  - U okviru ovog rada analizirani su uzorci sedimenata i zemljišta zaštićenog prirodnog dobra “Obrenovački zabran” u Obrenovcu. Uzorci su uzeti sa dva lokaliteta, priobalni uzorci sedimenta Save, i uzorci zemljišta iz močvare koja je često poplavljena vodama iz Kolubare. Ispitivanja su podrazumevala izolovanje rastvorne organske supstance, bitumen, metodom Soksklet ekstrakcije, razdvajanje frakcija hromatografijom na koloni, i analizu zasićenih i aromatičnih frakcija gasnohromatografsko-masenospektometrijskom analizom (GC-MS).
Cilj ovog istraživanja je utvrđivanje porekla organske supstance u uzorcima obalnih sedimenata Save i močvarnog zemljišta Obrenovačkog zabrana, na osnovu raspodele i relativne obilnosti ugljovodonika.
T1  - Organsko-geohemijska karakterizacija priobalnih sedimenata reke Save i močvarnog zemljišta Obrenovačkog zabrana
SP  - 1
EP  - 70
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5776
ER  - 

@mastersthesis{
author = "Vulićević, Biljana",
year = "2023",
abstract = "U okviru ovog rada analizirani su uzorci sedimenata i zemljišta zaštićenog prirodnog dobra “Obrenovački zabran” u Obrenovcu. Uzorci su uzeti sa dva lokaliteta, priobalni uzorci sedimenta Save, i uzorci zemljišta iz močvare koja je često poplavljena vodama iz Kolubare. Ispitivanja su podrazumevala izolovanje rastvorne organske supstance, bitumen, metodom Soksklet ekstrakcije, razdvajanje frakcija hromatografijom na koloni, i analizu zasićenih i aromatičnih frakcija gasnohromatografsko-masenospektometrijskom analizom (GC-MS).
Cilj ovog istraživanja je utvrđivanje porekla organske supstance u uzorcima obalnih sedimenata Save i močvarnog zemljišta Obrenovačkog zabrana, na osnovu raspodele i relativne obilnosti ugljovodonika.",
title = "Organsko-geohemijska karakterizacija priobalnih sedimenata reke Save i močvarnog zemljišta Obrenovačkog zabrana",
pages = "1-70",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5776"
}

Vulićević, B.. (2023). Organsko-geohemijska karakterizacija priobalnih sedimenata reke Save i močvarnog zemljišta Obrenovačkog zabrana. , 1-70.
https://hdl.handle.net/21.15107/rcub_cherry_5776

Vulićević B. Organsko-geohemijska karakterizacija priobalnih sedimenata reke Save i močvarnog zemljišta Obrenovačkog zabrana. 2023;:1-70.
https://hdl.handle.net/21.15107/rcub_cherry_5776 .

Vulićević, Biljana, "Organsko-geohemijska karakterizacija priobalnih sedimenata reke Save i močvarnog zemljišta Obrenovačkog zabrana" (2023):1-70,
https://hdl.handle.net/21.15107/rcub_cherry_5776 .

TY  - JOUR
AU  - Saheed, Ramadan Musbah M.
AU  - Knudsen, Tatjana Šolević
AU  - Faraj, Musbah Abduljalil M.
AU  - Nytoft, Hans Peter
AU  - Jovančićević, Branimir
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5795
AB  - Crude oil samples from the Sharara-C oil field (Concession NC-115, Murzuq Basin, SW Libya) were analysed by organic geochemical methods in order to infer the geochemical characteristics of their respective source rocks. Aromatic hydrocarbons were analysed by gas chromatography – mass spectrometry (GC-MS), and gas chromatography – tandem mass spectrometry (GC-MS-MS) was used to analyse saturated biomarkers. The Sharara-C oils are interpreted to have been generated by marine shales containing mixed terrigenous and marine organic materials deposited in an intermediate (suboxic) environment. Age-specific biomarker ratios indicated that the oils are older than Cretaceous, and maturation-related parameters pointed to their high thermal maturity. Consistent with previous studies, source rocks are inferred to be “hot” shales in the Lower Silurian Tanezzuft Formation. Almost all the parameter ratios calculated varied over a very narrow range, indicating that the investigated oils were compositionally similar. The only significant difference that was noted concerned the sterane/hopane ratios whose variation suggested that there was some variability in the composition of the source organic material. The organic geochemical parameters determined for the Sharara-C crude oils were compared with published data on other crude oils from Concession NC-115. Almost all the parameters agreed well with previously published data on oils from this part of the Murzuq Basin. The greatest deviation concerned the values of some of the maturity parameters. This tended to confirm the conclusions of previous studies concerning the presence of a number of distinct oil families and sub-families in the Sharara oil field area which are genetically related but which have different maturities.
T2  - Journal of Petroleum Geology
T1  - Geochemical Characteristics of Crude Oils from the Sharara-C Oil Field, Murzuq Basin, Southwestern Libya
VL  - 46
IS  - 1
SP  - 103
EP  - 123
DO  - 10.1111/jpg.12832
ER  - 

@article{
author = "Saheed, Ramadan Musbah M. and Knudsen, Tatjana Šolević and Faraj, Musbah Abduljalil M. and Nytoft, Hans Peter and Jovančićević, Branimir",
year = "2023",
abstract = "Crude oil samples from the Sharara-C oil field (Concession NC-115, Murzuq Basin, SW Libya) were analysed by organic geochemical methods in order to infer the geochemical characteristics of their respective source rocks. Aromatic hydrocarbons were analysed by gas chromatography – mass spectrometry (GC-MS), and gas chromatography – tandem mass spectrometry (GC-MS-MS) was used to analyse saturated biomarkers. The Sharara-C oils are interpreted to have been generated by marine shales containing mixed terrigenous and marine organic materials deposited in an intermediate (suboxic) environment. Age-specific biomarker ratios indicated that the oils are older than Cretaceous, and maturation-related parameters pointed to their high thermal maturity. Consistent with previous studies, source rocks are inferred to be “hot” shales in the Lower Silurian Tanezzuft Formation. Almost all the parameter ratios calculated varied over a very narrow range, indicating that the investigated oils were compositionally similar. The only significant difference that was noted concerned the sterane/hopane ratios whose variation suggested that there was some variability in the composition of the source organic material. The organic geochemical parameters determined for the Sharara-C crude oils were compared with published data on other crude oils from Concession NC-115. Almost all the parameters agreed well with previously published data on oils from this part of the Murzuq Basin. The greatest deviation concerned the values of some of the maturity parameters. This tended to confirm the conclusions of previous studies concerning the presence of a number of distinct oil families and sub-families in the Sharara oil field area which are genetically related but which have different maturities.",
journal = "Journal of Petroleum Geology",
title = "Geochemical Characteristics of Crude Oils from the Sharara-C Oil Field, Murzuq Basin, Southwestern Libya",
volume = "46",
number = "1",
pages = "103-123",
doi = "10.1111/jpg.12832"
}

Saheed, R. M. M., Knudsen, T. Š., Faraj, M. A. M., Nytoft, H. P.,& Jovančićević, B.. (2023). Geochemical Characteristics of Crude Oils from the Sharara-C Oil Field, Murzuq Basin, Southwestern Libya. in Journal of Petroleum Geology, 46(1), 103-123.
https://doi.org/10.1111/jpg.12832

Saheed RMM, Knudsen TŠ, Faraj MAM, Nytoft HP, Jovančićević B. Geochemical Characteristics of Crude Oils from the Sharara-C Oil Field, Murzuq Basin, Southwestern Libya. in Journal of Petroleum Geology. 2023;46(1):103-123.
doi:10.1111/jpg.12832 .

Saheed, Ramadan Musbah M., Knudsen, Tatjana Šolević, Faraj, Musbah Abduljalil M., Nytoft, Hans Peter, Jovančićević, Branimir, "Geochemical Characteristics of Crude Oils from the Sharara-C Oil Field, Murzuq Basin, Southwestern Libya" in Journal of Petroleum Geology, 46, no. 1 (2023):103-123,
https://doi.org/10.1111/jpg.12832 . .

TY  - THES
AU  - Petrović, Nevena
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5833
AB  - Cilj istraživanja u ovom radu je ispitivanje primene magnetičnog amino-funkcionalizovanog nanokompozita na bazi glicidil-metakrilata, kao potencijalnog sorbenta koji je prethodno sintetisan i okarakterisan, optimizacija procesa sorpcije dihlobenila iz vodenog rastvora i ispitivanje efikasnosti adsorpcije na realnim uzorcima.
T1  - Sorpcija dihlobenila pomoću magnetičnog poroznog amino-funkcionalizovanog nanokompozita
SP  - 7
EP  - 57
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5833
ER  - 

@mastersthesis{
author = "Petrović, Nevena",
year = "2023",
abstract = "Cilj istraživanja u ovom radu je ispitivanje primene magnetičnog amino-funkcionalizovanog nanokompozita na bazi glicidil-metakrilata, kao potencijalnog sorbenta koji je prethodno sintetisan i okarakterisan, optimizacija procesa sorpcije dihlobenila iz vodenog rastvora i ispitivanje efikasnosti adsorpcije na realnim uzorcima.",
title = "Sorpcija dihlobenila pomoću magnetičnog poroznog amino-funkcionalizovanog nanokompozita",
pages = "7-57",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5833"
}

Petrović, N.. (2023). Sorpcija dihlobenila pomoću magnetičnog poroznog amino-funkcionalizovanog nanokompozita. , 7-57.
https://hdl.handle.net/21.15107/rcub_cherry_5833

Petrović N. Sorpcija dihlobenila pomoću magnetičnog poroznog amino-funkcionalizovanog nanokompozita. 2023;:7-57.
https://hdl.handle.net/21.15107/rcub_cherry_5833 .

Petrović, Nevena, "Sorpcija dihlobenila pomoću magnetičnog poroznog amino-funkcionalizovanog nanokompozita" (2023):7-57,
https://hdl.handle.net/21.15107/rcub_cherry_5833 .

TY  - JOUR
AU  - Jednak Berić, Tanja
AU  - Avdalović, Jelena
AU  - Milić, Jelena
AU  - Teofilović, Vesna
AU  - Vrvić, Miroslav
AU  - Jovančićević, Branimir
AU  - Miletić, Srđan
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5977
AB  - Refinery wastes generated in conventional crude oil refining processes, or in accidental situations, are complex substrates for treatment and disposal. Petroleum desulphurisation catalysts can also be hazardous refinery waste. They contain various metals, such as cobalt, molybdenum, nickel and tungsten. In this paper, three petroleum refiner’s spent desulphurisation catalysts were investigated. These catalysts were not suitable for recycling and, therefore, were classified as hazardous waste. They were chemically characterised, including phase composition and their effect on a consortium of microorganisms used in the process of bioremediation. Catalysts contained up to 2.26 g kg−1 of total petroleum hydrocarbons, up to 56.7 g kg−1 of iron, 18.6 g kg−1 of molybdenum, and less than 0.1 mg kg−1 each of cobalt and nickel. These obtained results show that bioremediation of such waste is possible.
PB  - Taylor & Francis
T2  - Chemistry and Ecology
T1  - The influence on microorganisms of heavy metals from refiner’s spent desulphurisation catalysts
VL  - 39
IS  - 2
DO  - 10.1080/02757540.2022.2158185
ER  - 

@article{
author = "Jednak Berić, Tanja and Avdalović, Jelena and Milić, Jelena and Teofilović, Vesna and Vrvić, Miroslav and Jovančićević, Branimir and Miletić, Srđan",
year = "2023",
abstract = "Refinery wastes generated in conventional crude oil refining processes, or in accidental situations, are complex substrates for treatment and disposal. Petroleum desulphurisation catalysts can also be hazardous refinery waste. They contain various metals, such as cobalt, molybdenum, nickel and tungsten. In this paper, three petroleum refiner’s spent desulphurisation catalysts were investigated. These catalysts were not suitable for recycling and, therefore, were classified as hazardous waste. They were chemically characterised, including phase composition and their effect on a consortium of microorganisms used in the process of bioremediation. Catalysts contained up to 2.26 g kg−1 of total petroleum hydrocarbons, up to 56.7 g kg−1 of iron, 18.6 g kg−1 of molybdenum, and less than 0.1 mg kg−1 each of cobalt and nickel. These obtained results show that bioremediation of such waste is possible.",
publisher = "Taylor & Francis",
journal = "Chemistry and Ecology",
title = "The influence on microorganisms of heavy metals from refiner’s spent desulphurisation catalysts",
volume = "39",
number = "2",
doi = "10.1080/02757540.2022.2158185"
}

Jednak Berić, T., Avdalović, J., Milić, J., Teofilović, V., Vrvić, M., Jovančićević, B.,& Miletić, S.. (2023). The influence on microorganisms of heavy metals from refiner’s spent desulphurisation catalysts. in Chemistry and Ecology
Taylor & Francis., 39(2).
https://doi.org/10.1080/02757540.2022.2158185

Jednak Berić T, Avdalović J, Milić J, Teofilović V, Vrvić M, Jovančićević B, Miletić S. The influence on microorganisms of heavy metals from refiner’s spent desulphurisation catalysts. in Chemistry and Ecology. 2023;39(2).
doi:10.1080/02757540.2022.2158185 .

Jednak Berić, Tanja, Avdalović, Jelena, Milić, Jelena, Teofilović, Vesna, Vrvić, Miroslav, Jovančićević, Branimir, Miletić, Srđan, "The influence on microorganisms of heavy metals from refiner’s spent desulphurisation catalysts" in Chemistry and Ecology, 39, no. 2 (2023),
https://doi.org/10.1080/02757540.2022.2158185 . .

TY  - THES
AU  - Pantelić, Bogdan
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6075
AB  - Ranija istraživanja dokazala su da je biočađ veoma korisna materija u unapređenju kvaliteta zemljišta. U želji da se ispita potencijalno dejstvo na poboljšanje svojstava uzoraka zemljišta sa dve različite, ali geografski bliske lokacije sa planine Avala, označene kao AT1 i AT2, na kojima je niska stopa primanja sadnica hrastova, laboratorijski je simulirano 12 godišnjih doba, tj. tri godine, u skladu sa prosečnim vrednostima padavina i temperature za grad Beograd za period 2013-2021. Formirana su tri seta uzoraka. Jedan u kom su uzorci sa obe lokacije bez biočađi (označeni kao AT1 b i AT2 b), drugi i treći set kod kojih su uzorci stajali pomešani sa biočađi čija je masa 2% početne mase uzoraka, kroz 45 odnosno 214 dana, označenih kao AT1 45 d/AT2 45 d i AT1 214 d/AT2 214 d. Analiziranjem fotografija uzoraka kroz cikluse ne uočavaju se vidljive promene. Sakupljani su izluženi rastvori kojima je merena zapremina, električna provodljivost i pH-vrednost, a pre i posle svakog ciklusa uzorci su fotografisani. Zapremina izluženih rastvora je varirala, u zavisnosti od zasićenosti zemljišta vodom. Statistička obrada podataka je pokazala da statistički značajne razlika između merenih parametara ne postoje. Takođe je utvrđeno da postoje korelacije između zapremine i električne provodljivosti za uzorke, AT1 b, AT2 b i AT2 214 d, kao i zavisnost između zapremine i pH-vrednosti za uzorak AT2 45 d. Može se zaključiti da biočađ utiče u nekoj meri na uzorke, ali nedovoljno od značaja za praktičnu primenu, da li zbog nedovoljno duge pomešanosti uzoraka sa biočađi, njene koncentracije u uzorcima ili dužine trajanja eksperimenta, što svakako ukazuje da je ova istraživanja neophodno nastaviti.
T1  - Potencijalna primena biočađi u poboljšanju karakteristika zemljišta sa Avale
SP  - 1
EP  - 38
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6075
ER  - 

@misc{
author = "Pantelić, Bogdan",
year = "2023",
abstract = "Ranija istraživanja dokazala su da je biočađ veoma korisna materija u unapređenju kvaliteta zemljišta. U želji da se ispita potencijalno dejstvo na poboljšanje svojstava uzoraka zemljišta sa dve različite, ali geografski bliske lokacije sa planine Avala, označene kao AT1 i AT2, na kojima je niska stopa primanja sadnica hrastova, laboratorijski je simulirano 12 godišnjih doba, tj. tri godine, u skladu sa prosečnim vrednostima padavina i temperature za grad Beograd za period 2013-2021. Formirana su tri seta uzoraka. Jedan u kom su uzorci sa obe lokacije bez biočađi (označeni kao AT1 b i AT2 b), drugi i treći set kod kojih su uzorci stajali pomešani sa biočađi čija je masa 2% početne mase uzoraka, kroz 45 odnosno 214 dana, označenih kao AT1 45 d/AT2 45 d i AT1 214 d/AT2 214 d. Analiziranjem fotografija uzoraka kroz cikluse ne uočavaju se vidljive promene. Sakupljani su izluženi rastvori kojima je merena zapremina, električna provodljivost i pH-vrednost, a pre i posle svakog ciklusa uzorci su fotografisani. Zapremina izluženih rastvora je varirala, u zavisnosti od zasićenosti zemljišta vodom. Statistička obrada podataka je pokazala da statistički značajne razlika između merenih parametara ne postoje. Takođe je utvrđeno da postoje korelacije između zapremine i električne provodljivosti za uzorke, AT1 b, AT2 b i AT2 214 d, kao i zavisnost između zapremine i pH-vrednosti za uzorak AT2 45 d. Može se zaključiti da biočađ utiče u nekoj meri na uzorke, ali nedovoljno od značaja za praktičnu primenu, da li zbog nedovoljno duge pomešanosti uzoraka sa biočađi, njene koncentracije u uzorcima ili dužine trajanja eksperimenta, što svakako ukazuje da je ova istraživanja neophodno nastaviti.",
title = "Potencijalna primena biočađi u poboljšanju karakteristika zemljišta sa Avale",
pages = "1-38",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6075"
}

Pantelić, B.. (2023). Potencijalna primena biočađi u poboljšanju karakteristika zemljišta sa Avale. , 1-38.
https://hdl.handle.net/21.15107/rcub_cherry_6075

Pantelić B. Potencijalna primena biočađi u poboljšanju karakteristika zemljišta sa Avale. 2023;:1-38.
https://hdl.handle.net/21.15107/rcub_cherry_6075 .

Pantelić, Bogdan, "Potencijalna primena biočađi u poboljšanju karakteristika zemljišta sa Avale" (2023):1-38,
https://hdl.handle.net/21.15107/rcub_cherry_6075 .

TY  - JOUR
AU  - Štrbac, Snežana
AU  - Veselinović, Gorica
AU  - Antić, Nevena
AU  - Mijatović, Nevenka
AU  - Stojadinović, Sanja
AU  - Jovančićević, Branimir
AU  - Kašanin-Grubin, Milica
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6187
AB  - The main objective of this study was to analyze the capacity of Cedrus atlantica (Endl.) Manetti ex Carrière 1855 to accumulate macro- and microelements in order to assess the environmental status. The element concentrations were measured using X-ray Fluorescence (XRF) analysis. The obtained pH values in this study show that the urban soils are neutral to slightly alkaline with low OM content. Macroelements with the highest mean concentrations in soil are Si, Al, Fe, K, Mg, and Ca. The ratio > 2 was determined for mean concentrations of Ca in the soil and Mg in needles from the Zvezdara forest, and for mean concentrations of Cl, Ti, and Fe in needles from the Byford’s forest in relation to the reference site. The accumulation pattern of the macroelements based on the Biological Concentration Factor (BCF) values > 1 for needles is for P, S, Cl, and Ca. Microelements with the highest mean values in soil are Ba, Zr, Ce, Cr, Zn, Rb, Sr, V, and La. Microelements with the highest mean values in Atlas cedar needles are Ce, La, Ba, and Cs. The ratio > 2 was determined for Cr and V concentrations in the needles from the Byford’s and Zvezdara forests and for Cu concentrations in needles from the Byford’s forest in relation to the reference site. The accumulation pattern of the microelements based on the BCF for needles is higher for I, Cs, Mo, Ag, Cd, In, Sn, Sb, and Tl. Since differences in the concentrations of macro- and microelements in the urban areas and the reference site can be identified C. atlantica can be recommended for assessing the environmental status.
PB  - Springer
T2  - Trees
T1  - The macro- and microelements content in Cedrus atlantica (Endl.) Manetti ex Carrière (Pinaceae) needles as an indicator for assessing the environmental status
VL  - 37
IS  - 4
SP  - 1013
EP  - 1025
DO  - 10.1007/s00468-023-02401-9
ER  - 

@article{
author = "Štrbac, Snežana and Veselinović, Gorica and Antić, Nevena and Mijatović, Nevenka and Stojadinović, Sanja and Jovančićević, Branimir and Kašanin-Grubin, Milica",
year = "2023",
abstract = "The main objective of this study was to analyze the capacity of Cedrus atlantica (Endl.) Manetti ex Carrière 1855 to accumulate macro- and microelements in order to assess the environmental status. The element concentrations were measured using X-ray Fluorescence (XRF) analysis. The obtained pH values in this study show that the urban soils are neutral to slightly alkaline with low OM content. Macroelements with the highest mean concentrations in soil are Si, Al, Fe, K, Mg, and Ca. The ratio > 2 was determined for mean concentrations of Ca in the soil and Mg in needles from the Zvezdara forest, and for mean concentrations of Cl, Ti, and Fe in needles from the Byford’s forest in relation to the reference site. The accumulation pattern of the macroelements based on the Biological Concentration Factor (BCF) values > 1 for needles is for P, S, Cl, and Ca. Microelements with the highest mean values in soil are Ba, Zr, Ce, Cr, Zn, Rb, Sr, V, and La. Microelements with the highest mean values in Atlas cedar needles are Ce, La, Ba, and Cs. The ratio > 2 was determined for Cr and V concentrations in the needles from the Byford’s and Zvezdara forests and for Cu concentrations in needles from the Byford’s forest in relation to the reference site. The accumulation pattern of the microelements based on the BCF for needles is higher for I, Cs, Mo, Ag, Cd, In, Sn, Sb, and Tl. Since differences in the concentrations of macro- and microelements in the urban areas and the reference site can be identified C. atlantica can be recommended for assessing the environmental status.",
publisher = "Springer",
journal = "Trees",
title = "The macro- and microelements content in Cedrus atlantica (Endl.) Manetti ex Carrière (Pinaceae) needles as an indicator for assessing the environmental status",
volume = "37",
number = "4",
pages = "1013-1025",
doi = "10.1007/s00468-023-02401-9"
}

Štrbac, S., Veselinović, G., Antić, N., Mijatović, N., Stojadinović, S., Jovančićević, B.,& Kašanin-Grubin, M.. (2023). The macro- and microelements content in Cedrus atlantica (Endl.) Manetti ex Carrière (Pinaceae) needles as an indicator for assessing the environmental status. in Trees
Springer., 37(4), 1013-1025.
https://doi.org/10.1007/s00468-023-02401-9

Štrbac S, Veselinović G, Antić N, Mijatović N, Stojadinović S, Jovančićević B, Kašanin-Grubin M. The macro- and microelements content in Cedrus atlantica (Endl.) Manetti ex Carrière (Pinaceae) needles as an indicator for assessing the environmental status. in Trees. 2023;37(4):1013-1025.
doi:10.1007/s00468-023-02401-9 .

Štrbac, Snežana, Veselinović, Gorica, Antić, Nevena, Mijatović, Nevenka, Stojadinović, Sanja, Jovančićević, Branimir, Kašanin-Grubin, Milica, "The macro- and microelements content in Cedrus atlantica (Endl.) Manetti ex Carrière (Pinaceae) needles as an indicator for assessing the environmental status" in Trees, 37, no. 4 (2023):1013-1025,
https://doi.org/10.1007/s00468-023-02401-9 . .

TY  - JOUR
AU  - Spahić, Darko
AU  - Šajnović, Aleksandra
AU  - Burazer, Nikola
AU  - Radisavljević, Marija
AU  - Jovančićević, Branimir
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6260
AB  - With the objective to quantify the Neogene extensional geodynamic drivers of the Peri Pannonian Realm s.l., a series of 1D basin models were carried out by integrating the available geological and geochemical data extracted from the landlocked Toplica Basin (central-southern Serbia; Serbo-Macedonian Unit). The modeling was conducted on four wells located immediately south of Jastrebac Mt., in the area of the Toplica Basin. The investigated southernmost point of the Peri Pannonian Ream s.l. (areas surrounding the basin, to the south of rivers Danube and Sava) underwent intense tectonically-driven subsidence episodes, which lasted from the Lower Miocene up to the Pliocene. The restored Neogene burial history (subsidence rates), paleotemperature, and calibrated paleo-heat fluxes (or changes in the ancient crustal or basal heat flow) indicated a two-staged crustal stretching of the wider Toplica area. The combined tectonic, i.e., thermal subsidence, resulted in a very high sedimentation rate, having an average ca. 300–400 m/Ma (Čučale unit). The intense tectonically-driven subsidence is consistent with the involvement of extensional processes, affecting the crustal and lithospheric layers of the retreating Adria/Dinarides, amplified by a distant Carpathian rollback stage. The regional extension led to the asymmetric opening and the formation of the Toplica Lower Miocene mesosaline to the freshwater lacustrine system. Higher participation of mixed microbiologically reworked/terrestrial organic matter incorporated in oil-prone Type II kerogen mainly characterized the investigated lacustrine sedimentary sequence. The latest Oligocene–earliest Neogene subsidence onset was characterized by elevated temperatures, affecting the early development of the oil window (ca. at 16 Ma). The 1D models also showed that the Lower Čučale unit achieved ca. 50% transformation ratio for the Type II organic matter. The two intra-Neogene extensional episodes suggested the existence of the Early Neogene “syn-rift” stage, followed by a thermal sagging. The Neogene continuous thinning of the overriding Serbo-Macedonian continental crust contributed to the “negative inversion” of the former pre-Neogene nappes. Therefore, Neogene tectonic reactivation induced contemporaneous subsidence, further allowing the extensional rise of the Jastrebac core complex.
PB  - Elsevier
T2  - Geoenergy Science and Engineering
T1  - Neogene subsidence rates of the southern Peri Pannonian realm (1D basin modeling): Constraints on the extensional geodynamic drivers of the asymmetric Toplica basin (central-southern Serbia)
VL  - 226
SP  - 211714
DO  - 10.1016/j.geoen.2023.211714
ER  - 

@article{
author = "Spahić, Darko and Šajnović, Aleksandra and Burazer, Nikola and Radisavljević, Marija and Jovančićević, Branimir",
year = "2023",
abstract = "With the objective to quantify the Neogene extensional geodynamic drivers of the Peri Pannonian Realm s.l., a series of 1D basin models were carried out by integrating the available geological and geochemical data extracted from the landlocked Toplica Basin (central-southern Serbia; Serbo-Macedonian Unit). The modeling was conducted on four wells located immediately south of Jastrebac Mt., in the area of the Toplica Basin. The investigated southernmost point of the Peri Pannonian Ream s.l. (areas surrounding the basin, to the south of rivers Danube and Sava) underwent intense tectonically-driven subsidence episodes, which lasted from the Lower Miocene up to the Pliocene. The restored Neogene burial history (subsidence rates), paleotemperature, and calibrated paleo-heat fluxes (or changes in the ancient crustal or basal heat flow) indicated a two-staged crustal stretching of the wider Toplica area. The combined tectonic, i.e., thermal subsidence, resulted in a very high sedimentation rate, having an average ca. 300–400 m/Ma (Čučale unit). The intense tectonically-driven subsidence is consistent with the involvement of extensional processes, affecting the crustal and lithospheric layers of the retreating Adria/Dinarides, amplified by a distant Carpathian rollback stage. The regional extension led to the asymmetric opening and the formation of the Toplica Lower Miocene mesosaline to the freshwater lacustrine system. Higher participation of mixed microbiologically reworked/terrestrial organic matter incorporated in oil-prone Type II kerogen mainly characterized the investigated lacustrine sedimentary sequence. The latest Oligocene–earliest Neogene subsidence onset was characterized by elevated temperatures, affecting the early development of the oil window (ca. at 16 Ma). The 1D models also showed that the Lower Čučale unit achieved ca. 50% transformation ratio for the Type II organic matter. The two intra-Neogene extensional episodes suggested the existence of the Early Neogene “syn-rift” stage, followed by a thermal sagging. The Neogene continuous thinning of the overriding Serbo-Macedonian continental crust contributed to the “negative inversion” of the former pre-Neogene nappes. Therefore, Neogene tectonic reactivation induced contemporaneous subsidence, further allowing the extensional rise of the Jastrebac core complex.",
publisher = "Elsevier",
journal = "Geoenergy Science and Engineering",
title = "Neogene subsidence rates of the southern Peri Pannonian realm (1D basin modeling): Constraints on the extensional geodynamic drivers of the asymmetric Toplica basin (central-southern Serbia)",
volume = "226",
pages = "211714",
doi = "10.1016/j.geoen.2023.211714"
}

Spahić, D., Šajnović, A., Burazer, N., Radisavljević, M.,& Jovančićević, B.. (2023). Neogene subsidence rates of the southern Peri Pannonian realm (1D basin modeling): Constraints on the extensional geodynamic drivers of the asymmetric Toplica basin (central-southern Serbia). in Geoenergy Science and Engineering
Elsevier., 226, 211714.
https://doi.org/10.1016/j.geoen.2023.211714

Spahić D, Šajnović A, Burazer N, Radisavljević M, Jovančićević B. Neogene subsidence rates of the southern Peri Pannonian realm (1D basin modeling): Constraints on the extensional geodynamic drivers of the asymmetric Toplica basin (central-southern Serbia). in Geoenergy Science and Engineering. 2023;226:211714.
doi:10.1016/j.geoen.2023.211714 .

Spahić, Darko, Šajnović, Aleksandra, Burazer, Nikola, Radisavljević, Marija, Jovančićević, Branimir, "Neogene subsidence rates of the southern Peri Pannonian realm (1D basin modeling): Constraints on the extensional geodynamic drivers of the asymmetric Toplica basin (central-southern Serbia)" in Geoenergy Science and Engineering, 226 (2023):211714,
https://doi.org/10.1016/j.geoen.2023.211714 . .

TY  - JOUR
AU  - Stojković, Pavle
AU  - Kostić, Ana
AU  - Lupšić, Ema
AU  - Jovanović, Nataša Terzić
AU  - Novaković, Miroslav
AU  - Nedialkov, Paraskev
AU  - Trendafilova, Antoaneta
AU  - Pešić, Milica
AU  - Opsenica, Igor M.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6258
AB  - The synthesis of 24 hybrid molecules, consisting of naturally occurring sclareol (SCL) and synthetic 1,2,4-triazolo[1,5-a]pyrimidines (TPs), is described. New compounds were designed with the aim of improving the cytotoxic properties, activity, and selectivity of the parent compounds. Six analogs (12a-f) contained 4-benzylpiperazine linkage, while 4-benzyldiamine linkage was present in eighteen derivatives (12g-r and 13a-f). Hybrids 13a-f consist of two TP units. After purification, all hybrids (12a-r and 13a-f), as well as their precursors (9a-e and 11a-c), were tested on human glioblastoma U87 cells. More than half of the tested synthesized molecules, 16 out of 31, caused a significant reduction of U87 cell viability (more than 75% reduction) at 30 µM. The concentration-dependent cytotoxicity of these 16 compounds was also examined on U87 cells, corresponding multidrug-resistant (MDR) U87-TxR cells with increased P-glycoprotein (P-gp) expression and activity, and normal lung fibroblasts MRC-5. Importantly, 12l and 12r were active in the nanomolar range, while seven compounds (11b, 11c, 12i, 12l, 12n, 12q, and 12r) were more selective towards glioblastoma cells than SCL. All compounds except 12r evaded MDR, showing even better cytotoxicity in U87-TxR cells. In particular, 11c, 12a, 12g, 12j, 12k, 12m, 12n, and SCL showed collateral sensitivity. Hybrid compounds 12l, 12q, and 12r decreased P-gp activity to the same extent as a well-known P-gp inhibitor - tariquidar (TQ). Hybrid compound 12l and its precursor 11c affected different cellular processes including the cell cycle, cell death, and mitochondrial membrane potential, and changed the levels of reactive oxygen and nitrogen species (ROS/RNS) in glioblastoma cells. Collateral sensitivity towards MDR glioblastoma cells was caused by the modulation of oxidative stress accompanied by inhibition of mitochondria.
PB  - Elsevier
T2  - Bioorganic Chemistry
T1  - Novel hybrids of sclareol and 1,2,4-triazolo[1,5-a]pyrimidine show collateral sensitivity in multidrug-resistant glioblastoma cells
VL  - 138
SP  - 106605
DO  - 10.1016/j.bioorg.2023.106605
ER  - 

@article{
author = "Stojković, Pavle and Kostić, Ana and Lupšić, Ema and Jovanović, Nataša Terzić and Novaković, Miroslav and Nedialkov, Paraskev and Trendafilova, Antoaneta and Pešić, Milica and Opsenica, Igor M.",
year = "2023",
abstract = "The synthesis of 24 hybrid molecules, consisting of naturally occurring sclareol (SCL) and synthetic 1,2,4-triazolo[1,5-a]pyrimidines (TPs), is described. New compounds were designed with the aim of improving the cytotoxic properties, activity, and selectivity of the parent compounds. Six analogs (12a-f) contained 4-benzylpiperazine linkage, while 4-benzyldiamine linkage was present in eighteen derivatives (12g-r and 13a-f). Hybrids 13a-f consist of two TP units. After purification, all hybrids (12a-r and 13a-f), as well as their precursors (9a-e and 11a-c), were tested on human glioblastoma U87 cells. More than half of the tested synthesized molecules, 16 out of 31, caused a significant reduction of U87 cell viability (more than 75% reduction) at 30 µM. The concentration-dependent cytotoxicity of these 16 compounds was also examined on U87 cells, corresponding multidrug-resistant (MDR) U87-TxR cells with increased P-glycoprotein (P-gp) expression and activity, and normal lung fibroblasts MRC-5. Importantly, 12l and 12r were active in the nanomolar range, while seven compounds (11b, 11c, 12i, 12l, 12n, 12q, and 12r) were more selective towards glioblastoma cells than SCL. All compounds except 12r evaded MDR, showing even better cytotoxicity in U87-TxR cells. In particular, 11c, 12a, 12g, 12j, 12k, 12m, 12n, and SCL showed collateral sensitivity. Hybrid compounds 12l, 12q, and 12r decreased P-gp activity to the same extent as a well-known P-gp inhibitor - tariquidar (TQ). Hybrid compound 12l and its precursor 11c affected different cellular processes including the cell cycle, cell death, and mitochondrial membrane potential, and changed the levels of reactive oxygen and nitrogen species (ROS/RNS) in glioblastoma cells. Collateral sensitivity towards MDR glioblastoma cells was caused by the modulation of oxidative stress accompanied by inhibition of mitochondria.",
publisher = "Elsevier",
journal = "Bioorganic Chemistry",
title = "Novel hybrids of sclareol and 1,2,4-triazolo[1,5-a]pyrimidine show collateral sensitivity in multidrug-resistant glioblastoma cells",
volume = "138",
pages = "106605",
doi = "10.1016/j.bioorg.2023.106605"
}

Stojković, P., Kostić, A., Lupšić, E., Jovanović, N. T., Novaković, M., Nedialkov, P., Trendafilova, A., Pešić, M.,& Opsenica, I. M.. (2023). Novel hybrids of sclareol and 1,2,4-triazolo[1,5-a]pyrimidine show collateral sensitivity in multidrug-resistant glioblastoma cells. in Bioorganic Chemistry
Elsevier., 138, 106605.
https://doi.org/10.1016/j.bioorg.2023.106605

Stojković P, Kostić A, Lupšić E, Jovanović NT, Novaković M, Nedialkov P, Trendafilova A, Pešić M, Opsenica IM. Novel hybrids of sclareol and 1,2,4-triazolo[1,5-a]pyrimidine show collateral sensitivity in multidrug-resistant glioblastoma cells. in Bioorganic Chemistry. 2023;138:106605.
doi:10.1016/j.bioorg.2023.106605 .

Stojković, Pavle, Kostić, Ana, Lupšić, Ema, Jovanović, Nataša Terzić, Novaković, Miroslav, Nedialkov, Paraskev, Trendafilova, Antoaneta, Pešić, Milica, Opsenica, Igor M., "Novel hybrids of sclareol and 1,2,4-triazolo[1,5-a]pyrimidine show collateral sensitivity in multidrug-resistant glioblastoma cells" in Bioorganic Chemistry, 138 (2023):106605,
https://doi.org/10.1016/j.bioorg.2023.106605 . .

TY  - THES
AU  - Ćulum, Nataša
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6094
AB  - U prvom segmentu ovog završnog rada upotrebljena je metoda za sintezu p-nitrozobenzena oksidacijom anilina, nakon čega je sintetisani p-nitrozobenzen iskorišćen za reakcije kondenzacije sa različitim derivatima anilina. Ova metoda je poznata pod nazivom Baeyer-Mills-ova reakcija i najčešće je korišćena za sintezu diazenske funkcionalne grupe. U nastavku završnog rada urađena je fotoizomerizacija sintetisanih derivata diazena i analiza spektara dva izomera (trans i cis). Azobenzeni su molekuli koji nakon zračenja bliskim UV zracima izomerizuju, odnosno prelaze iz jednog izomera u drugi. Reakcija fotoizomerizacije diazena je jedinstvena i kao takva je našla veliku primjenu u različitim oblastima industrije, prvenstveno u farmaceutskoj industriji i medicinskoj hemiji.
T1  - Sinteza i fotoizomerizacija derivata azobenzena
SP  - 1
EP  - 23
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6094
ER  - 

@misc{
author = "Ćulum, Nataša",
year = "2023",
abstract = "U prvom segmentu ovog završnog rada upotrebljena je metoda za sintezu p-nitrozobenzena oksidacijom anilina, nakon čega je sintetisani p-nitrozobenzen iskorišćen za reakcije kondenzacije sa različitim derivatima anilina. Ova metoda je poznata pod nazivom Baeyer-Mills-ova reakcija i najčešće je korišćena za sintezu diazenske funkcionalne grupe. U nastavku završnog rada urađena je fotoizomerizacija sintetisanih derivata diazena i analiza spektara dva izomera (trans i cis). Azobenzeni su molekuli koji nakon zračenja bliskim UV zracima izomerizuju, odnosno prelaze iz jednog izomera u drugi. Reakcija fotoizomerizacije diazena je jedinstvena i kao takva je našla veliku primjenu u različitim oblastima industrije, prvenstveno u farmaceutskoj industriji i medicinskoj hemiji.",
title = "Sinteza i fotoizomerizacija derivata azobenzena",
pages = "1-23",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6094"
}

Ćulum, N.. (2023). Sinteza i fotoizomerizacija derivata azobenzena. , 1-23.
https://hdl.handle.net/21.15107/rcub_cherry_6094

Ćulum N. Sinteza i fotoizomerizacija derivata azobenzena. 2023;:1-23.
https://hdl.handle.net/21.15107/rcub_cherry_6094 .

Ćulum, Nataša, "Sinteza i fotoizomerizacija derivata azobenzena" (2023):1-23,
https://hdl.handle.net/21.15107/rcub_cherry_6094 .

TY  - THES
AU  - Pupavac, Dunja A.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6112
AB  - 4-(Fenilazo)difenilamin (PDA) je jedinjenje od značaja jer je našlo primenu kao univerzalni 
kolorimetrijski indikator za precizno određivanje koncentracije različitih jakih baza, Lewis-ovih kiselina 
i hidridnih reagenasa. Standardna procedura za njegovu sintezu podrazumeva upotrebu reakcije azo kuplovanja. Imajući u vidu ograničenja ove reakcije, kao što su često niska regioselektivnost i osetljivost 
na prisustvo određenih funkcionalnih grupa, za cilj ovog završnog rada postavljena je alternativna sinteza 
PDA i njegovih derivata koja bi prevazišla ova ograničenja. U prvom segmentu ovog završnog rada 
upotrebljena je reakcija Baeyer-Mills-ove kondenzacije za sintezu derivata azobenzena. U nastavku 
istraživanja ispitana je upotreba ovako dobijenih derivata za sintezu 4-(fenilazo)difenilamina (PDA) i 
njegovih derivata primenom paladijum-katalizovane reakcije Buchwald-Hartwig-ovog ukrštenog 
kuplovanja.
T1  - Sinteza 4-(fenilazo)difenilamina i njegovih derivata primenom reakcije  Buchwald-Hartwig-ovog ukrštenog kuplovanja
SP  - 1
EP  - 20
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6112
ER  - 

@mastersthesis{
author = "Pupavac, Dunja A.",
year = "2023",
abstract = "4-(Fenilazo)difenilamin (PDA) je jedinjenje od značaja jer je našlo primenu kao univerzalni 
kolorimetrijski indikator za precizno određivanje koncentracije različitih jakih baza, Lewis-ovih kiselina 
i hidridnih reagenasa. Standardna procedura za njegovu sintezu podrazumeva upotrebu reakcije azo kuplovanja. Imajući u vidu ograničenja ove reakcije, kao što su često niska regioselektivnost i osetljivost 
na prisustvo određenih funkcionalnih grupa, za cilj ovog završnog rada postavljena je alternativna sinteza 
PDA i njegovih derivata koja bi prevazišla ova ograničenja. U prvom segmentu ovog završnog rada 
upotrebljena je reakcija Baeyer-Mills-ove kondenzacije za sintezu derivata azobenzena. U nastavku 
istraživanja ispitana je upotreba ovako dobijenih derivata za sintezu 4-(fenilazo)difenilamina (PDA) i 
njegovih derivata primenom paladijum-katalizovane reakcije Buchwald-Hartwig-ovog ukrštenog 
kuplovanja.",
title = "Sinteza 4-(fenilazo)difenilamina i njegovih derivata primenom reakcije  Buchwald-Hartwig-ovog ukrštenog kuplovanja",
pages = "1-20",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6112"
}

Pupavac, D. A.. (2023). Sinteza 4-(fenilazo)difenilamina i njegovih derivata primenom reakcije  Buchwald-Hartwig-ovog ukrštenog kuplovanja. , 1-20.
https://hdl.handle.net/21.15107/rcub_cherry_6112

Pupavac DA. Sinteza 4-(fenilazo)difenilamina i njegovih derivata primenom reakcije  Buchwald-Hartwig-ovog ukrštenog kuplovanja. 2023;:1-20.
https://hdl.handle.net/21.15107/rcub_cherry_6112 .

Pupavac, Dunja A., "Sinteza 4-(fenilazo)difenilamina i njegovih derivata primenom reakcije  Buchwald-Hartwig-ovog ukrštenog kuplovanja" (2023):1-20,
https://hdl.handle.net/21.15107/rcub_cherry_6112 .

TY  - THES
AU  - Vuković, Jakša
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6165
AB  - Glavni cilj ovog rada je optimizacija uslova Buchwald-Hartwig-ove reakcije za dobijanje određenog N-fenil-4-aminoaminohinolina. Pored optimizacije reakcije, ispitan je i uticaj supstituenta na fenilnom jezgru na prinos iste reakcije.
T1  - Biološka aktivnost određenih N-fenil-4-aminohinolina
SP  - 1
EP  - 28
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6165
ER  - 

@mastersthesis{
author = "Vuković, Jakša",
year = "2023",
abstract = "Glavni cilj ovog rada je optimizacija uslova Buchwald-Hartwig-ove reakcije za dobijanje određenog N-fenil-4-aminoaminohinolina. Pored optimizacije reakcije, ispitan je i uticaj supstituenta na fenilnom jezgru na prinos iste reakcije.",
title = "Biološka aktivnost određenih N-fenil-4-aminohinolina",
pages = "1-28",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6165"
}

Vuković, J.. (2023). Biološka aktivnost određenih N-fenil-4-aminohinolina. , 1-28.
https://hdl.handle.net/21.15107/rcub_cherry_6165

Vuković J. Biološka aktivnost određenih N-fenil-4-aminohinolina. 2023;:1-28.
https://hdl.handle.net/21.15107/rcub_cherry_6165 .

Vuković, Jakša, "Biološka aktivnost određenih N-fenil-4-aminohinolina" (2023):1-28,
https://hdl.handle.net/21.15107/rcub_cherry_6165 .

TY  - JOUR
AU  - Koračak, Ljiljana
AU  - Lupšić, Ema
AU  - Terzić-Jovanović, Nataša
AU  - Jovanović, Mirna
AU  - Novakovic, Miroslav
AU  - Nedialkov, Paraskev
AU  - Trendafilova, Antoaneta
AU  - Zlatović, Mario
AU  - Pešić, Milica
AU  - Opsenica, Igor
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6245
AB  - The synthesis of 17 hybrid molecules, consisting of artesunate, a derivative of naturally occurring artemisinin, and synthetic 4-aryl-2-aminopyrimidines, is described. New compounds were designed to improve the parent compounds' cytotoxic properties, activity, and selectivity. The synthesized hybrid molecules (15a–f with ethylenediamine linker and 16a–k with piperazine linker), as well as their precursors – pyrimidine derivatives (13a–f and 14a–k), artemisinin, and artesunate, were tested on sensitive and multidrug-resistant (MDR) human non-small cell lung carcinoma (NSCLC) cells. All hybrid compounds with piperazine linker 16a–k were selective toward NSCLC cells and displayed IC50 values below 5 μM. Although they showed similar anticancer potency as artesunate, their selectivity against cancer cells was considerably improved. Importantly, 16h–k hybrid compounds were able to evade MDR phenotype, inhibit P-glycoprotein (P-gp) activity, and increase the sensitivity of MDR NSCLC cells to doxorubicin (DOX). The inhibition of P-gp activity induced by 16h–j was stronger than the one obtained with artesunate. Among these four hybrid compounds, 16k was the most potent anticancer agent with similar IC50 values of around 1.5 μM (for comparison – over 3.1 μM for artesunate) in sensitive and MDR NSCLC cells.
PB  - Royal Society of Chemistry
T2  - New Journal of Chemistry
T2  - New Journal of ChemistryNew J. Chem.
T1  - Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells
VL  - 47
IS  - 14
SP  - 6844
EP  - 6855
DO  - 10.1039/D3NJ00427A
ER  - 

@article{
author = "Koračak, Ljiljana and Lupšić, Ema and Terzić-Jovanović, Nataša and Jovanović, Mirna and Novakovic, Miroslav and Nedialkov, Paraskev and Trendafilova, Antoaneta and Zlatović, Mario and Pešić, Milica and Opsenica, Igor",
year = "2023",
abstract = "The synthesis of 17 hybrid molecules, consisting of artesunate, a derivative of naturally occurring artemisinin, and synthetic 4-aryl-2-aminopyrimidines, is described. New compounds were designed to improve the parent compounds' cytotoxic properties, activity, and selectivity. The synthesized hybrid molecules (15a–f with ethylenediamine linker and 16a–k with piperazine linker), as well as their precursors – pyrimidine derivatives (13a–f and 14a–k), artemisinin, and artesunate, were tested on sensitive and multidrug-resistant (MDR) human non-small cell lung carcinoma (NSCLC) cells. All hybrid compounds with piperazine linker 16a–k were selective toward NSCLC cells and displayed IC50 values below 5 μM. Although they showed similar anticancer potency as artesunate, their selectivity against cancer cells was considerably improved. Importantly, 16h–k hybrid compounds were able to evade MDR phenotype, inhibit P-glycoprotein (P-gp) activity, and increase the sensitivity of MDR NSCLC cells to doxorubicin (DOX). The inhibition of P-gp activity induced by 16h–j was stronger than the one obtained with artesunate. Among these four hybrid compounds, 16k was the most potent anticancer agent with similar IC50 values of around 1.5 μM (for comparison – over 3.1 μM for artesunate) in sensitive and MDR NSCLC cells.",
publisher = "Royal Society of Chemistry",
journal = "New Journal of Chemistry, New Journal of ChemistryNew J. Chem.",
title = "Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells",
volume = "47",
number = "14",
pages = "6844-6855",
doi = "10.1039/D3NJ00427A"
}

Koračak, L., Lupšić, E., Terzić-Jovanović, N., Jovanović, M., Novakovic, M., Nedialkov, P., Trendafilova, A., Zlatović, M., Pešić, M.,& Opsenica, I.. (2023). Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells. in New Journal of Chemistry
Royal Society of Chemistry., 47(14), 6844-6855.
https://doi.org/10.1039/D3NJ00427A

Koračak L, Lupšić E, Terzić-Jovanović N, Jovanović M, Novakovic M, Nedialkov P, Trendafilova A, Zlatović M, Pešić M, Opsenica I. Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells. in New Journal of Chemistry. 2023;47(14):6844-6855.
doi:10.1039/D3NJ00427A .

Koračak, Ljiljana, Lupšić, Ema, Terzić-Jovanović, Nataša, Jovanović, Mirna, Novakovic, Miroslav, Nedialkov, Paraskev, Trendafilova, Antoaneta, Zlatović, Mario, Pešić, Milica, Opsenica, Igor, "Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells" in New Journal of Chemistry, 47, no. 14 (2023):6844-6855,
https://doi.org/10.1039/D3NJ00427A . .